keyword
https://read.qxmd.com/read/38419611/pulmonary-vein-isolation-durability-after-very-high-power-short-duration-ablation-utilizing-a-very-close-protocol-the-fast-and-furious-redo-study
#1
JOURNAL ARTICLE
Christian-H Heeger, Behnam Subin, Charlotte Eitel, Sorin Ștefan Popescu, Huong-Lan Phan, Roman Mamaev, Lorenzo Bartoli, Niels Große, Samuel Reincke, Anna Traub, Delgado Lopez, Bettina Kirstein, Sascha Hatahet, Karl-Heinz Kuck, Julia Vogler, Roland R Tilz
BACKGROUND: Very high-power short-duration (vHP-SD) radiofrequency (RF) ablation of atrial fibrillation (AF) treatment by pulmonary vein isolation (PVI) aims for safer, more effective and faster procedures. Although acute efficacy and safety for PVI was recently shown data on chronic PVI durability is limited. Here chronic PVI durability was evaluated during repeat electrophysiological procedures in patients after initial vHP-SD and conventional RF based PVI. METHODS: A total of 25 consecutive patients with repeat left atrial procedures after initial vHP-SD based PVI were included in this study...
February 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38153515/effects-of-disinfection-with-a-vinegar-hydrogen-peroxide-mixture-on-the-surface-characteristics-of-denture-acrylic-resins
#2
JOURNAL ARTICLE
Érico Fabbro Teixeira, Ana Luíza Gonçalves Girundi, Larissa Dolfini Alexandrino, Laura Lourenço Morel, Marcus Vinicius Rocha de Almeida, Vinicius Rodrigues Dos Santos, Sara Fraga, Wander José da Silva, Cristiane Machado Mengatto
OBJECTIVE: This study aimed to investigate changes in the surface characteristics of two denture resins when disinfected with a vinegar-hydrogen peroxide (VHP) mixture. MATERIALS AND METHODS: Microwave-polymerized or 3D printed acrylic resin disks were immersed for 900 min (simulating 90 daily uses) in the following solutions (N = 10): water; 0.5% sodium hypochlorite; hydrogen peroxide and water dilution (1:1 ratio); vinegar and water dilution (1:1 ratio); and VHP mixture...
December 28, 2023: Clinical Oral Investigations
https://read.qxmd.com/read/38152378/bacterial-and-fungal-bioburden-reduction-on-material-surfaces-using-various-sterilization-techniques-suitable-for-spacecraft-decontamination
#3
JOURNAL ARTICLE
Shunta Kimura, Shu Ishikawa, Nobuya Hayashi, Kazuhisa Fujita, Yuko Inatomi, Shino Suzuki
Planetary protection is a guiding principle aiming to prevent microbial contamination of the solar system by spacecraft (forward contamination) and extraterrestrial contamination of the Earth (backward contamination). Bioburden reduction on spacecraft, including cruise and landing systems, is required to prevent microbial contamination from Earth during space exploration missions. Several sterilization methods are available; however, selecting appropriate methods is essential to eliminate a broad spectrum of microorganisms without damaging spacecraft components during manufacturing and assembly...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38108620/comparative-study-of-female-pelvic-floor-among-undeformed-high-resolution-thin-sectional-anatomical-visible-human-images-and-mri-and-ultrasound-images
#4
JOURNAL ARTICLE
Qingfang Gong, Yangyun Wang, Li Duan, Ling Lei, Jia Liu, Jie Yao, Jing Qi, Zhou Xu, Yongjian Nian, Yi Wu
PURPOSE: Using visible human, MRI and ultrasound images, we aim to provide an anatomical basis for the identification and diagnosis of pelvic floor structure and disease by ultrasound imaging. METHODS: One Chinese visible human (CVH) image, one American visible human image, 9 MRI images of normal volunteers, and 40 ultrasound images of normal volunteers or pelvic organ prolapse patients were used. Pelvic organs, pelvic floor muscles, and the connective tissue in CVH, VHP, MRI, and ultrasound images were selected for comparative study...
December 18, 2023: Journal of Clinical Ultrasound: JCU
https://read.qxmd.com/read/38096104/an-in-silico-testbed-for-fast-and-accurate-mr-labeling-of-orthopedic-implants
#5
JOURNAL ARTICLE
Gregory M Noetscher, Peter J Serano, Marc Horner, Alexander Prokop, Jonathan Hanson, Kyoko Fujimoto, James Brown, Ara Nazarian, Jerome Ackerman, Sergey N Makaroff
One limitation on the ability to monitor health in older adults using magnetic resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the population, as does the pervasiveness of conditions requiring MRI studies for diagnosis (musculoskeletal diseases, infections, or cancer). The present study describes a novel multiphysics implant modeling testbed using the following approaches with two examples: (1) an in silico human model based on the widely available Visible Human Project (VHP) cryo-section dataset; (2) a finite element method (FEM) modeling software workbench from Ansys (Electronics Desktop/Mechanical) to model MR radio frequency (RF) coils and the temperature rise modeling in heterogeneous media...
December 14, 2023: ELife
https://read.qxmd.com/read/38068384/biophysical-behavior-of-very-high-power-short-duration-radiofrequency-ablation-in-pulmonary-vein-isolation-fast-but-gently-implications-for-a-successful-procedure
#6
JOURNAL ARTICLE
Eduardo Celentano, Ernesto Cristiano, Barbara Ignatiuk, Elena Bia, Lorenzo Girotto, Nicola Tarantino, Natasja M S De Groot
The very high-power short-duration (vHP-SD) ablation strategy is an alternative for pulmonary vein isolation (PVI) in patients with paroxysmal atrial fibrillation (PAF). However, the acute procedural biophysical behavior of successful lesion creation by means of this technique is still unexplored. We performed a retrospective case-control study aimed at evaluating the behavior of vHP-SD ablation parameters with the QDOT MICRO™ ablation catheter (Biosense Webster) compared with standard radiofrequency (RF) ablation with the THERMOCOOL SMARTTOUCH® ablation catheter...
November 26, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38055299/oh-roaming-during-the-ozonolysis-of-%C3%AE-pinene-a-new-route-to-highly-oxygenated-molecules
#7
JOURNAL ARTICLE
Stephen J Klippenstein, Sarah N Elliott
The formation of low-volatility organic compounds in the ozonolysis of α-pinene, the dominant atmospheric monoterpene, provides an important route to aerosol formation. In this work, we consider a previously unexplored set of pathways for the formation of highly oxygenated molecules in α-pinene ozonolysis. Pioneering, direct experimental observations of Lester and co-workers have demonstrated a significant production of hydroxycarbonyl products in the dissociation of Criegee intermediates. Theoretical analyses indicate that this production arises from OH roaming-induced pathways during the OO fission of the vinylhydroperoxides (VHPs), which in turn come from internal H transfers in the Criegee intermediates...
December 6, 2023: Journal of Physical Chemistry. A
https://read.qxmd.com/read/37894224/advances-in-vaporized-hydrogen-peroxide-reusable-medical-device-sterilization-cycle-development-technology-review-and-patent-trends
#8
REVIEW
M R Karimi Estahbanati
Vaporized hydrogen peroxide (VHP) terminal sterilization is one of the most promising techniques for sterilizing temperature-sensitive medical instruments like endoscopes. This technique requires only electricity and sterilant containers to perform the sterilization process in less than 1 h without any substantial safety concerns for patients, personnel, and the environment. This review studies recent advances and future trends in VHP sterilization cycle development using U.S. patent applications and 510(k) premarket notifications...
October 15, 2023: Microorganisms
https://read.qxmd.com/read/37833295/the-novel-sterilization-device-the-prototype-testing
#9
JOURNAL ARTICLE
Robert Nowak, Paweł Wityk, Anna Wierzbicka-Woś, Waldemar Gos, Dorota Kostrzewa-Nowak
Currently, there are numerous methods that can be used to neutralize pathogens (i.e., devices, tools, or protective clothing), but the sterilizing agent must be selected so that it does not damage or change the properties of the material to which it is applied. Dry sterilization with hydrogen peroxide gas (VHP) in combination with UV-C radiation is well described and effective method of sterilization. This paper presents the design, construction, and analysis of a novel model of sterilization device. Verification of the sterilization process was performed, using classical microbiological methods and flow cytometry, on samples containing Geobacillus stearothermophilus spores, Bacillus subtilis spores, Escherichia coli, and Candida albicans...
October 13, 2023: Scientific Reports
https://read.qxmd.com/read/37796333/the-homeodomain-transcription-factor-ceh-37-regulates-pmk-1-p38-mapk-pathway-to-protect-against-intestinal-infection-via-the-phosphatase-vhp-1
#10
JOURNAL ARTICLE
Fang Liu, Hongjiao Zhang, Haijuan Wang, Xinting Zhu, Sanhua Li, Nian Jiang, Changyan Yu, Yun Liu, Yi Xiao
Increasing evidence indicate that the expression of defense genes at the right place and the right time are regulated by host-defense transcription factors. However, the precise mechanisms of this regulation are not well understood. Homeodomain transcription factors, encoded by homeobox genes, play crucial role for the development of multicellular eukaryotes. In this study, we demonstrated that homeodomain transcription factor CEH-37 (known as OTX2 in mammals) was a key transcription factor for host defense in Caenorhabditis elegans...
October 5, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37751805/vaporized-hydrogen-peroxide-sterilization-in-the-production-of-protein-therapeutics-uptake-and-effects-on-product-quality
#11
REVIEW
Michael Meleties, Bailey M Cooper, Daniela Marcano-James, Amardeep S Bhalla, Mohammed Shameem
The aseptic filling of drug products is carried out in pharmaceutical isolators that have been sterilized. A commonly used method for achieving a high level of sterility assurance is vaporized hydrogen peroxide (VHP) sterilization, which is favorable to other methods, such as ethylene oxide sterilization, due to its low cycle times and non-toxic residuals. While VHP cycles are often employed to create a sterile environment within an isolator, they can leave residual levels of hydrogen peroxide behind that can enter the product during fill-finish operations...
September 24, 2023: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/37649909/an-in-silico-testbed-for-fast-and-accurate-mr-labeling-of-orthopaedic-implants
#12
Gregory M Noetscher, Peter J Serano, Marc Horner, Alexander Prokop, Jonathan Hanson, Kyoko Fujimoto, James E Brown, Ara Nazarian, Jerome Ackerman, Sergey N Makaroff
One limitation on the ability to monitor health in older adults using Magnetic Resonance (MR) imaging is the presence of implants, where the prevalence of implantable devices (orthopedic, cardiac, neuromodulation) increases in the population, as does the pervasiveness of conditions requiring MRI studies for diagnosis (musculoskeletal diseases, infections, or cancer). The present study describes a novel multiphysics implant modeling testbed using the following approaches with two examples: an in-silico human model based on the widely available Visible Human Project (VHP) cryo- section dataset; a finite element method (FEM) modeling software workbench from Ansys (Electronics Desktop/Mechanical) to model MR radio frequency (RF) coils and the temperature rise modeling in heterogeneous media...
July 18, 2023: bioRxiv
https://read.qxmd.com/read/37640503/equipment-and-methods-for-concurrently-housing-germfree-and-gnotobiotic-mice-in-the-same-room
#13
JOURNAL ARTICLE
Anastasia F Muino, Nicole R Compo, Bo M Everett, Dominique F Abrahams, Margi K Baldwin, Tara N James, Susan E Wanner, M Jane Perkins, Courtnee E Parr, Norman D Wiltshire, Emily L Miedel, Robert W Engelman
Here, we combined the use of 2 technologies that have not previously been used together-a positively pressurized isolatorIVC (IsoIVC-P) and a modular isolator with integrated vaporized hydrogen peroxide (VHP) technology-to develop highlytractable and scalable methods to support long-term maintenance of germfree mouse colonies and the concurrent use of germfreeand gnotobiotic mice in the same room. This space-efficient system increases the practicality of microbiome studies.Specifically, the exterior surfaces of microbially similar IsoIVC-P were sterilized by using VHP prior to opening the cagesand handling the mice therein...
August 28, 2023: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/37584747/mars-2020-mission-biological-return-sample-contamination-control-approach-and-verification
#14
JOURNAL ARTICLE
Fei Chen, Cynthia Ly, Ioannis Mikellides, Douglas Bernard, Moogega Cooper
The Mars 2020 Perseverance rover is equipped with a Sample Caching System (SCS) designed to collect and cache martian core and regolith samples for potential return to Earth. To ensure the integrity of these samples, the mission requirements for each encapsulated sample for return is less than one Earth-sourced viable organism (VO) and more than a 99.9% probability of being free of any Earth-sourced VO. To satisfy the stringent biological contamination requirements in support of return sample science investigations, special bioburden mitigation and reduction approaches were developed and implemented for SCS hardware that would directly contact or be in close proximity to the martian samples...
August 2023: Astrobiology
https://read.qxmd.com/read/37331115/post-high-pressure-temperature-and-time-overlooked-parameters-in-high-pressure-treatment-of-bacterial-spores
#15
JOURNAL ARTICLE
Rosa Heydenreich, Alessia I Delbrück, Alexander Mathys
High pressure (HP) processing has high potential for bacterial spore inactivation with minimal thermal input. To advance HP germination and subsequent inactivation of spores, this study explored the physiological state of HP-treated spores using flow cytometry (FCM). Bacillus subtilis spores were treated at 550 MPa and 60 °C (very HP (vHP)) in buffer, incubated after the HP treatment, and stained for FCM analysis with SYTO16 indicating germination and propidium iodide (PI) indicating membrane damage...
June 13, 2023: International Journal of Food Microbiology
https://read.qxmd.com/read/37257650/the-influence-of-percutaneous-vertebral-augmentation-techniques-on-recompression-in-patients-suffering-from-osteoporotic-vertebral-compression-fractures-percutaneous-vertebroplasty-vs-balloon-kyphoplasty
#16
JOURNAL ARTICLE
Fikret Sahinturk, Erkin Sonmez, Selim Ayhan, Salih Gulsen, Cem Yilmaz
PURPOSE: The purpose of this study was to determine whether percutaneous vertebroplasty (PVP) and balloon kyphoplasty (BK) have any mid-long term effects on the structural integrity of augmented vertebrae. METHODS: According to our hospital records, a total of 351 patients underwent BK and PVP due to osteoporotic vertebral compression fractures between the years 2010 and 2020. The demographical, surgical and radiological characteristics of the patients were retrospectively analyzed by using the electronic hospital records and picture archiving and communication system (PACS)...
May 29, 2023: World Neurosurgery
https://read.qxmd.com/read/37189280/a-segmentation-method-of-serialized-human-body-slices-based-on-matting-strategy-and-skeleton-extraction
#17
JOURNAL ARTICLE
Bin Liu, Zhengyang Wu, Chenlu Wang, Shiyu Pang, Jingzhu Pei, Jianxin Zhang, Liang Yang
INTRODUCTION: In this paper, a semiautomatic image segmentation method for the serialized body slices of the Visible Human Project (VHP) is proposed. METHOD: In our method, we first verified the effectiveness of the shared matting method for the VHP slices and utilized it to segment a single image. Then, to meet the need for the automatic segmentation of serialized slice images, a method based on the parallel refinement method and flood-fill method was designed...
May 15, 2023: Current medical imaging
https://read.qxmd.com/read/37027418/uk-vessel-health-and-preservation-framework-2020-a-users-survey
#18
JOURNAL ARTICLE
Carole Hallam, Hannah Griffin, Valya Weston
The review and update of the UK Vessel Health and Preservation Framework 2020 (VHP2020) was undertaken by a working group that included members of the Infection Prevention Society, the Royal College of Nursing, the National Infusion and Vascular Access Society and the Medusa Advisory Board and was launched in 2020. The VHP working group developed a survey to understand whether the VHP2020 had reached its intended audience, and what respondents thought were the benefits and drawbacks of its use in practice. Although the survey response was lower than expected, the responses received were largely positive and have provided feedback on how the VHP2020 is being used and some of the benefits...
April 6, 2023: British Journal of Nursing: BJN
https://read.qxmd.com/read/36828157/hippocampus-modulates-vocalizations-responses-at-early-auditory-centers
#19
JOURNAL ARTICLE
Alex T L Leong, Eddie C Wong, Xunda Wang, Ed X Wu
Despite its prominence in learning and memory, hippocampal influence in early auditory processing centers remains unknown. Here, we examined how hippocampal activity modulates sound-evoked responses in the auditory midbrain and thalamus using optogenetics and functional MRI (fMRI) in rodents. Ventral hippocampus (vHP) excitatory neuron stimulation at 5 Hz evoked robust hippocampal activity that propagates to the primary auditory cortex. We then tested 5 Hz vHP stimulation paired with either natural vocalizations or artificial/noise acoustic stimuli...
February 22, 2023: NeuroImage
https://read.qxmd.com/read/36586333/triphenyl-phosphate-induced-reproductive-toxicity-through-the-jnk-signaling-pathway-in-caenorhabditis-elegans
#20
JOURNAL ARTICLE
Chongli Shi, Chen Wang, Lingjun Zeng, Yi Peng, Yeyong Li, Haibin Hao, Yang Zheng, Chao Chen, Haibo Chen, Jin Zhang, Minghui Xiang, Yuan Huang, Hui Li
Triphenyl phosphate (TPHP) is a widely used aryl organophosphate flame retardant (OPFR) that has attracted attention due to its frequent detection in the environment and living organisms. To date, the reproductive toxicity of TPHP has been investigated in organisms, but its molecular mechanisms are not fully understood. Caenorhabditis elegans (C. elegans) is the ideal animal for the study of reproductive toxicity following environmental pollutants, with short generation times, intact reproductive structures, and hermaphroditic fertilization...
December 20, 2022: Journal of Hazardous Materials
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