Jiawen Huang, Jiayu Li, Yuan Peng, Tianqi Cui, Jingyi Guo, Siwei Duan, Kaili Zhou, Shangyi Huang, Jiabing Chen, Qincheng Yi, Min Qiu, Tingting Chen, Xiaoqin Wu, Chenlu Ma, Ziyi Zhang, Yi Zheng, Xi Tang, Yanqing Pang, Lei Zhang, Chong Zhong, Yong Gao
BACKGROUND: In addition to abnormal liver inflammation, the main symptoms of non-alcoholic steatohepatitis (NASH) are often accompanied by gastrointestinal digestive dysfunction, consistent with the concept of spleen deficiency (SD) in traditional Chinese medicine. As an important metabolic sensor, whether peroxisome proliferator-activated receptor alpha (PPARα) participates in regulating the occurrence and development of NASH with SD (NASH-SD) remains to be explored. METHODS: Clinical liver samples were collected for RNA-seq analysis...
2024: Frontiers in Immunology