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https://www.readbyqxmd.com/read/29908506/a-framework-for-performing-comparative-lca-between-repairing-flooded-houses-and-construction-of-dikes-in-non-stationary-climate-with-changing-risk-of-flooding
#1
Thomas Hennequin, Hjalte Jomo Danielsen Sørup, Yan Dong, Karsten Arnbjerg-Nielsen
Sustainable flood management is a basic societal need. In this article, life cycle assessment is used to compare two ways to maintain the state of a coastal urban area in a changing climate with increasing flood risk. On one side, the construction of a dike, a hard and proactive scenario, is modelled using a bottom up approach. On the other, the systematic repair of houses flooded by sea surges, a post-disaster measure, is assessed using a Monte Carlo simulation allowing for aleatory uncertainties in predicting future sea level rise and occurrences of extreme events...
June 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29908403/nanosilica-modified-by-polydimethylsiloxane-depolymerized-and-chemically-bound-to-nanoparticles-or-physically-bound-to-unmodified-or-modified-surfaces-structure-and-interfacial-phenomena
#2
V M Gun'ko, E M Pakhlov, O V Goncharuk, L S Andriyko, Yu M Nychiporuk, D Yu Balakin, D Sternik, A Derylo-Marczewska
Three polydimethylsiloxanes (PDMS200, PDMS1000, and PDMS12500 with numbers showing the viscosity values dependent on the molecular weight) were used for adsorption (14-95 wt% PDMS) onto unmodified and PDMS-modified (16.7 wt% PDMS using dimethyl carbonate (DMC) as a siloxane bond breaking reagent) nanosilica A-300. The materials were studied using microscopy, infrared spectroscopy, thermodesorption, calorimetry, ethanol and water/ethanol evaporation, nitrogen adsorption-desorption, and quantum chemical methods...
June 8, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29908394/system-on-chip-design-of-the-cortical-diencephalic-centre-of-the-lower-urinary-tract
#3
Francisco Maciá Pérez, Leandro Zambrano Méndez, José Vicente Berná Martínez, Roberto Sepúlveda Lima
This article presents the design of a field programmable gate array (FPGA)-based prototype of a system on chip (SoC) capable of behaving as one of the nerve centres comprising the neuroregulatory system in humans: the cortical-diencephalic nerve centre. The neuroregulatory system is a complex nerve system consisting of a heterogeneous group of nerve centres. These centres are distributed throughout the length of the spinal cord, are autonomous, communicate via interneurons, and govern and regulate the behaviour of multiple organs and systems in the human body...
June 13, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29908387/epilepsy-mortality-trends-in-cuba-compared-with-england-and-wales-1987-2010
#4
Ramón Suárez-Medina, Lilia María Morales-Chacón, Silvia Josefina Venero-Fernández, Clarence Liu, Andrew W Fogarty, Aidan Neligan
There are limited epilepsy mortality data from developing countries and Latin America in particular. We examined national epilepsy mortality data from Cuba and contrasted them with comparable data from England and Wales. National epilepsy mortality data for Cuba between the years 1987 and 2010 were obtained from the Medical Records and Health Statistics Bureau of the Cuban Public Health Ministry (www.sld.cu/sitios/dne/) with the corresponding mortality data from England and Wales obtained from the UK Office of National Statistics (ONS, www...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29908348/accuracy-of-magnetic-resonance-imaging-techniques-for-parotid-tumors-a-systematic-review-and-meta-analysis
#5
Ying-Ying Liang, Fan Xu, Yuan Guo, Jin Wang
OBJECTIVE: To assess the added benefit of combining different MRI techniques for preoperative diagnosis of parotid tumors when compared to conventional MRI and advanced MRI techniques alone with meta-analysis. METHODS: A comprehensive PubMed electronic database search was performed for original diagnostic studies up to July 2017. The methodologic quality of each study was evaluated by two independent reviewers who used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool...
June 7, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29908335/platelet-derived-growth-factor-coated-decellularized-meniscus-scaffold-for-integrative-healing-of-meniscus-tears
#6
Kwang Il Lee, Merissa Olmer, Jihye Baek, Darryl D D'Lima, Martin K Lotz
The aim of this study was to examine the potential of platelet-derived growth factor (PDGF)-coated decellularized meniscus scaffold in mediating integrative healing of meniscus tears by inducing endogenous cell migration. Fresh bovine meniscus was chemically decellularized and covalently conjugated with heparin and PDGF-BB. In vitro PDGF release kinetics was measured. The scaffold was transplanted into experimental tears in avascular bovine meniscus explants and cultured for 2 and 4 weeks. The number migrating and proliferating cells at the borderline between the scaffold and injured explant and PDGF receptor-β (PDGFR β) expressing cells were counted...
June 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29908312/detection-of-neural-light-scattering-activity-in-vivo-optical-transmittance-studies-in-the-rat-brain
#7
Wen-Ju Pan, Seung Yup Lee, Jacob Billings, Maysam Nezafati, Waqas Majeed, Erin Buckley, Shella Keilholz
Optical studies of ex vivo brain slices where blood is absent show that neural activity is accompanied by significant intrinsic optical signals (IOS) related to activity-dependent scattering changes in neural tissue. However, the neural scattering signals have been largely ignored in vivo in widely-used IOS methods where absorption contrast from hemoglobin was employed. Changes in scattering were observed on a time scale of seconds in previous brain slice IOS studies, similar to the time scale for the hemodynamic response...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29908259/astroglial-camp-signalling-in-space-and-time
#8
REVIEW
Anemari Horvat, Nina Vardjan
To maintain a high level of specificity and normal cell function, the cyclic adenosine monophosphate (cAMP) pathway is tightly regulated in space and time. Recent advances in cAMP reporter technology have provided insights into spatial-temporal characteristics of cAMP signalling in individual living cells, including astrocytes. Astrocytes are glial cells in the central nervous system with many homeostatic functions. In contrast to neurons, astrocytes are electrically silent, but, in response to extracellular stimuli through activation of surface receptors, they can increase intracellular levels of secondary messengers, e...
June 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29908239/the-psychostimulant-%C3%A2-cis-4-4-dimethylaminorex-4-4-dmar-interacts-with-human-plasmalemmal-and-vesicular-monoamine-transporters
#9
Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitte
(±)-cis-4,4'-Dimethylaminorex (4,4'-DMAR) is a new psychoactive substance (NPS) that has been associated with 31 fatalities and other adverse events in Europe between June 2013 and February 2014. We used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-DMAR on human high-affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT). In addition, we assessed its binding affinities to monoamine receptors and transporters. Furthermore, we investigated the interaction of 4,4'-DMAR with the vesicular monoamine transporter 2 (VMAT2) in rat phaeochromocytoma (PC12) cells and synaptic vesicles prepared from human striatum...
June 13, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29908227/hypogastric-preservation-using-retrograde-endovascular-bypass
#10
Mathew Wooster, Paul Armstrong, Martin Back
OBJECTIVE: Maintenance of pelvic circulation has been connected to reduced risks of ischemic colitis, buttock claudication, erectile dysfunction, and spinal cord ischemia during the treatment of extensive aorto-iliac aneurysmal disease. We evaluate the mid to late follow up of a cohort of patients treated using one preservation technique, the endovascular external (EIA) to internal (IIA) iliac artery bypass. METHODS: All patients undergoing elective retrograde EIA-IIA endovascular bypass at a single institution were retrospectively reviewed over a ten-year period from 2006-2016...
June 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29908226/visfatin-alters-the-cytokine-and-matrix-degrading-enzyme-profile-during-osteogenic-and-adipogenic-msc-differentiation
#11
Lali Tsiklauri, Janina Werner, Marian Kampschulte, Klaus W Frommer, Lucija Berninger, Martina Irrgang, Kristina Glenske, Dirk Hose, Thaqif El Khassawna, Jörn Pons-Kühnemann, Stefan Rehart, Sabine Wenisch, Ulf Müller-Ladner, Elena Neumann
OBJECTIVES: Age-related bone loss is associated with bone marrow adiposity. Adipokines (e.g. visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis. Thus, the presence of adipokines and MMPs in bone marrow and their effects on MSC differentiation were analyzed. METHODS: MSC and RNA were isolated from femoral heads after hip replacement surgery of OA or osteoporotic femoral neck fracture (FF) patients...
June 13, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29908225/disentangling-the-interaction-of-sex-differences-and-hemispheric-specialization-for-face-processing-evidence-from-erps
#12
Joanna Stasch, Bettina Mohr, Andres H Neuhaus
Recent studies on face processing and its hemispheric lateralization suggest that inconsistencies in earlier findings might be partially explained by sex differences, as findings from event-related potential studies indicated a more asymmetric functioning of the visual cortex during face encoding in men, whereas women seemed to display a more bilateral activation pattern. The aim of this study was to further investigate the role of sex differences in hemispheric specialization during face recognition. Fifty-four healthy participants (27 females and 27 males) engaged in a familiarity decision task in which famous and unfamiliar faces were presented in a lateralized tachistoscopic fashion with unilateral und bilateral presentation modes and measurement of event-related potentials and behavioral responses...
June 13, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29908220/an-automated-multiparametric-mri-quantitative-imaging-prostate-habitat-risk-scoring-system-for-defining-external-beam-radiotherapy-boost-volumes
#13
Radka Stoyanova, Felix Chinea, Deukwoo Kwon, Isildinha M Reis, Yohann Tschudi, Nestor A Parra, Adrian L Breto, Kyle R Padgett, Alan Dal Pra, Matthew C Abramowitz, Oleksandr N Kryvenko, Sanoj Punnen, Alan Pollack
PURPOSE: To develop a prostate tumor habitat risk scoring (HRS) system based on multiparametric MRI (mpMRI) referenced to prostatectomy Gleason Score (GS) for automatic delineation of Gross Tumor Volumes (GTVs). A workflow for integration of HRS into radiotherapy (RT) boost volume dose escalation was developed in the framework of a Phase II randomized clinical trial (BLaStM). MATERIALS AND METHODS: An automated quantitative mpMRI based 10 point pixel by pixel method was optimized to prostatectomy GSs and volumes using referenced Dynamic Contrast Enhanced and Apparent Diffusion Coefficient sequences...
June 13, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29908170/daily-activity-patterns-of-movement-and-refuge-use-in-triatoma-gerstaeckeri-and-rhodnius-prolixus-hemiptera-reduviidae-vectors-of-the-chagas-disease-parasite
#14
Jillian D Wormington, Cassidy Gillum, Alyssa C Meyers, Gabriel L Hamer, Sarah A Hamer
Transmission risk for vector borne disease is greatest during periods of heightened vector activity. Triatomine bugs (Hemiptera: Reduviidae), which transmit Trypanosoma cruzi, the causative agent of Chagas disease, are generally considered nocturnal, but their patterns of activity in controlled settings have rarely been studied. We quantified activity patterns across a 24-hour period in nymphs of two triatomine species: (1) Triatoma gerstaeckeri Stål, a North American triatomine which is closely associated with sylvatic and peridomestic hosts, and (2) Rhodnius prolixus Stål, a Central and South American triatomine that thrives in the domestic environment...
June 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29908166/antineoplastic-activity-of-mitomycin-c-formulated-in-nanoemulsions-based-essential-oils-on-hela-cervical-cancer-cells
#15
Mayson H Alkhatib, Waad A Al-Otaibi, Abdulwahab Noor Wali
Combining the essential oils (ESSOs) with the chemotherapeutic agent, mitomycin C (MMC), in nanoparticle can be beneficial in cancer therapy. The aim of the current study was to in vitro evaluate the antineoplastic effect of MMC, formulated in two different nanoemulsions (NE) based on two ESSOs, chamomile (Ch) and garlic (Gar), on HeLa cervical cancer cells. The z-average diameter of Ch-NE has slightly increased from 83.39 ± 12.85 nm to 91.18 ± 5.79 nm when mixed with MMC (Ch-MMC) whereas the z-average diameter of Gar-NE has markedly increased from 50...
June 13, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29908163/matrix-metalloproteinases-are-regulated-by-microrna-320-in-macrophages-and-are-associated-with-aortic-dissection
#16
Mingfang Liao, Sili Zou, Yan Bao, Jie Jin, Junlin Yang, Yandong Liu, Mark Green, Futang Yang, Lefeng Qu
Aortic dissection (AD) is the circumferential or transversal tear of the aorta wall that allows blood to infiltrate the layers. MicroRNA (miR) analyses have demonstrated a correlation between miR-320 family and AD. The underlying mechanism is yet unclear. The matrix metalloproteinases (MMPs) are a group of proteolytic enzymes that could catalyze the degeneration of the extracellular matrix and the destruction of the vasculature. In this study, we investigated whether miR-320 presented a role in regulating the production of MMPs in aortic dissection...
June 13, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29908123/cold-atmospheric-plasma-treatment-inhibits-growth-in-colorectal-cancer-cells
#17
Christin Schneider, Stephanie Arndt, Julia L Zimmermann, Yangfang Li, Sigrid Karrer, Anja-Katrin Bosserhoff
Plasma oncology is a relatively new field of research. Recent developments have indicated that cold atmospheric plasma (CAP) technology is an interesting new therapeutic approach to cancer treatment. In this study, p53 wildtype (LoVo) and human p53 mutated (HT29 and SW480) colorectal cancer cells were treated with the miniFlatPlaSter - a device particularly developed for the treatment of tumor cells - that uses the Surface Micro Discharge (SMD) technology for plasma production in air. The present study analyzed the effects of plasma on colorectal cancer cells in vitro and on normal colon tissue ex vivo...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29908040/dual-energy-ct-for-noninvasive-staging-of-liver-fibrosis-accuracy-of-iodine-density-measurements-from-contrast-enhanced-data
#18
Keitaro Sofue, Masakatsu Tsurusaki, Achille Mileto, Tomoko Hyodo, Kosuke Sasaki, Tatsuya Nishii, Takaaki Chikugo, Norihisa Yada, Masatoshi Kudo, Kazuro Sugimura, Takamichi Murakami
AIM: To investigate whether iodine density measurements from contrast-enhanced dual-energy CT data can noninvasively stage liver fibrosis. METHODS: This single-center, prospective study was approved by our IRB with written informed consent. Forty-seven consecutive patients (26 men and 21 women; mean age, 63.1 years) with chronic liver disease underwent contrast-enhanced dual-energy CT of the liver (noncontrast, arterial, portal venous, and equilibrium phase images), followed by liver biopsy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29908013/patient-reported-disease-activity-and-adverse-pregnancy-outcomes-in-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#19
Nathaniel Harris, Amanda Eudy, Megan Clowse
OBJECTIVES: While increased rheumatic disease activity during pregnancy has been associated with adverse pregnancy outcomes, this activity is typically assessed by the physician. Little is known, however, about the association between patient-reported measures of disease activity and pregnancy outcomes. METHODS: Univariate and multivariable regression models were used to assess the relationship between patient and physician-reported measures of disease activity and adverse pregnancy outcomes in 225 patients with lupus or rheumatoid arthritis (RA) enrolled in a prospective registry at a single academic center from 2008-2016...
June 15, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29907986/redox-triggered-folding-of-self-assembled-coordination-polymers-incorporating-viologen-units
#20
Wathiq Sattar Abdul-Hassan, Denis Roux, Christophe Bucher, Saioa Cobo, Florian Molton, Eric Saint-Aman, Guy Royal
We report the study of stimuli-responsive Zn(II) and Fe(II) coordination polymers (MC34+ or MC24+ with M = Fe2+ or Zn2+). These soluble metallopolymers were formed spontaneously by reaction of an organic ligand (C34+ or C24+) with one molar equivalent of metal ions. The C34+ and C24+ ligands incorporate two chelating terpyridine groups bridged by a redox responsive hinge featuring two viologen units (viologen = N,N'-dialkyl-4,4'-bipyridinium) linked either through propyl (C34+) or ethyl (C24+) chains. The viologen units in the polymer chains were reduced (1e per viologen group) either by bulk electrolysis or by visible-light irradiation carried out in the presence of a photosensitizer...
June 15, 2018: Chemistry: a European Journal
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