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https://www.readbyqxmd.com/read/29037015/comparison-of-spot-sign-blend-sign-and-black-hole-sign-for-outcome-prediction-in-patients-with-intracerebral-hemorrhage
#1
Peter B Sporns, Michael Schwake, André Kemmling, Jens Minnerup, Wolfram Schwindt, Thomas Niederstadt, Rene Schmidt, Uta Hanning
BACKGROUND AND PURPOSE: Blend sign (BS) and black hole sign (BHS) on non-contrast computed tomography (NCCT) and spot sign (SS) on CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored. METHODS: In this retrospective study, inclusion criteria were: 1) spontaneous ICH and 2) NCCT and CTA performed on admission within 6 hours after onset of symptoms...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29037011/visibility-of-ct-early-ischemic-change-is-significantly-associated-with-time-from-stroke-onset-to-baseline-scan-beyond-the-first-3-hours-of-stroke-onset
#2
Jian Gao, Mark W Parsons, Hiroyuki Kawano, Christopher R Levi, Tiffany-Jane Evans, Longting Lin, Andrew Bivard
BACKGROUND AND PURPOSE: Non-contrast brain computed tomography (NCCT) remains the most common imaging modality employed to select patients for thrombolytic therapy in acute ischemic stroke. The current study used the Alberta Stroke Program Early CT Score (ASPECTS) to identify early ischemic changes on brain NCCT imaging with the aim to investigate whether a relationship exists between time from symptoms onset to NCCT with the presence of early ischaemic change quantified by ASPECTS. METHODS: We studied 1,329 ischemic stroke patients who had NCCT within 8 hours of stroke onset...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036930/automatic-hotspot-and-sun-glint-detection-in-uav-multispectral-images
#3
Damian Ortega-Terol, David Hernandez-Lopez, Rocio Ballesteros, Diego Gonzalez-Aguilera
Last advances in sensors, photogrammetry and computer vision have led to high-automation levels of 3D reconstruction processes for generating dense models and multispectral orthoimages from Unmanned Aerial Vehicle (UAV) images. However, these cartographic products are sometimes blurred and degraded due to sun reflection effects which reduce the image contrast and colour fidelity in photogrammetry and the quality of radiometric values in remote sensing applications. This paper proposes an automatic approach for detecting sun reflections problems (hotspot and sun glint) in multispectral images acquired with an Unmanned Aerial Vehicle (UAV), based on a photogrammetric strategy included in a flight planning and control software developed by the authors...
October 15, 2017: Sensors
https://www.readbyqxmd.com/read/29036885/fairness-and-eligibility-to-long-term-care-an-analysis-of-the-factors-driving-inequality-and-inequity-in-the-use-of-home-care-for-older-europeans
#4
Stefania Ilinca, Ricardo Rodrigues, Andrea E Schmidt
In contrast with the case of health care, distributional fairness of long-term care (LTC) services in Europe has received limited attention. Given the increased relevance of LTC in the social policy agenda it is timely to evaluate the evidence on inequality and horizontal inequity by socio-economic status (SES) in the use of LTC and to identify the socio-economic factors that drive them. We address both aspects and reflect on the sensitivity of inequity estimates to adopting different definitions of legitimate drivers of care need...
October 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29036876/image-artifacts-and-noise-reduction-algorithm-for-cone-beam-computed-tomography-with-low-signal-projections
#5
Fu-Qiang Yang, Ding-Hua Zhang, Kui-Dong Huang, Ya-Fei Yang, Jin-Ming Liao
This study aims to investigate and test a new image reconstruction algorithm applying to the low-signal projections to generate high quality images by reducing the artifacts and noise in the cone-beam computed tomography (CBCT). For the low-signal and noisy projections, a multiple sampling method is first utilized in projection domain to suppress environmental noise, which guarantees the accuracy of the data for reconstruction, simultaneously. Next, a fuzzy entropy based method with block matching 3D (BM3D) filtering algorithm is employed to improve the image quality to reduce artifacts and noise in image domain...
October 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29036875/three-novel-accurate-pixel-driven-projection-methods-for-2d-ct-and-3d-epr-imaging
#6
Zhiwei Qiao, Gage Redler, Zhiguo Gui, Yuhua Qian, Boris Epel, Howard Halpern
OBJECTIVES: This work aims to explore more accurate pixel-driven projection methods for iterative image reconstructions in order to reduce high-frequency artifacts in the generated projection image. METHODS: Three new pixel-driven projection methods namely, small-pixel-large-detector (SPLD), linear interpolation based (LIB) and distance anterpolation based (DAB), were proposed and applied to reconstruct images. The performance of these methods was evaluated in both two-dimensional (2D) computed tomography (CT) images via the modified FORBILD phantom and three-dimensional (3D) electron paramagnetic resonance (EPR) images via the 6-spheres phantom...
October 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29036854/functional-repertoire-of-interleukin-6-in-the-central-nervous-system-a-review
#7
Klaus Heese
In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036832/neuropathological-comparison-of-adult-onset-and-juvenile-huntington-s-disease-with-cerebellar-atrophy-a-report-of%C3%A2-a%C3%A2-father-and-son
#8
Caitlin S Latimer, Margaret E Flanagan, Patrick J Cimino, Suman Jayadev, Marie Davis, Zachary S Hoffer, Thomas J Montine, Luis F Gonzalez-Cuyar, Thomas D Bird, C Dirk Keene
BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in huntingtin (HTT) on chromosome 4. Anticipation can cause longer repeat expansions in children of HD patients. Juvenile Huntington's disease (JHD), defined as HD arising before age 20, accounts for 5-10% of HD cases, with cases arising in the first decade accounting for approximately 1%. Clinically, JHD differs from the predominately choreiform adult onset Huntington's disease (AOHD) with variable presentations, including symptoms such as myoclonus, seizures, Parkinsonism, and cognitive decline...
October 11, 2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/29036827/validation-by-magnetic-resonance-imaging-of-the-diagnostic-potential-of-a-heptapeptide-functionalized-imaging-probe-targeted-to-amyloid-%C3%AE-and-able-to-cross-the-blood-brain-barrier
#9
Séverine André, Emilie Ansciaux, Elamine Saidi, Lionel Larbanoix, Dimitri Stanicki, Denis Nonclercq, Luce Vander Elst, Sophie Laurent, Robert N Muller, Carmen Burtea
The diagnosis of Alzheimer's disease (AD) is a critical step in the management of patients. We have developed a non-invasive diagnosis tool based on magnetic resonance molecular imaging (MRMI) of amyloid-β peptide using ultra-small particles of iron oxide (USPIO) functionalized with a disulfide constrained cyclic heptapeptide (PHO) identified by phage display (USPIO-PHO). After previously demonstrating the optimal pharmacologic properties of USPIO-PHO and its capacity to cross the blood-brain barrier (BBB), the ability of USPIO-PHO to target amyloid plaques (AP) by MRMI has been validated in the present work on AD transgenic mice...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036800/quantitative-parameters-of-contrast-enhanced-ultrasonography-for-assessment-of-renal-pathology-a-preliminary-study-in-chronic-kidney-disease
#10
Wen-Qi Yang, Shan Mou, Yao Xu, Li Xu, Feng-Hua Li, Hong-Li Li
No abstract text is available yet for this article.
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29036794/assessing-the-effect-of-different-operation-techniques-on-postoperative-duplex-ultrasound-quality-after-carotid-endarterectomy
#11
E Grambow, T Heller, P Wieneke, C Weiß, E Klar, M Weinrich
BACKGROUND: Duplex ultrasound is the first choice in diagnostics and surveillance of stenoses of the internal carotid arteries before and even after surgery. Therefore, the quality of duplex ultrasound is crucial to investigate these vascular pathologies. OBJECTIVE: Aim of this study was the evaluation whether different surgical techniques affect the postoperative quality of duplex ultrasound. METHODS: In a time period from January to May 2015 duplex ultrasound of the cervical vessels was performed in 75 patients after unilateral endarterectomy of the internal carotid artery at our department between 2006 and 2012...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29036701/mismatch-negativity-but-not-p300-is-associated-with-functional-disability-in-schizophrenia
#12
Holly K Hamilton, Veronica B Perez, Judith M Ford, Brian J Roach, Judith Jaeger, Daniel H Mathalon
Mismatch negativity (MMN) and P300 event-related potential (ERP) reductions in schizophrenia (SZ) reflect preattentive and attention-mediated auditory processing deficits, respectively. Although both have been linked to cognitive deficits in SZ, their relative contributions to real-world functioning are unclear. We sought to determine the functional significance of disrupted auditory processing in SZ by examining MMN and P300 in typically disabled low-functioning patients and in patients with high levels of independent role functioning...
August 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036698/chromosomal-context-affects-the-molecular-evolution-of-sex-linked-genes-and-their-autosomal-counterparts-in-turtles-and-other-vertebrates
#13
Srihari Radhakrishnan, Nicole Valenzuela
Sex chromosomes evolve differently from autosomes because natural selection acts distinctly on them given their reduced recombination and smaller population size. Various studies of sex-linked genes compared to different autosomal genes within species support these predictions. Instead, here we take a novel alternative approach comparing the rate of evolution between subsets of genes that are sex-linked in selected reptiles/vertebrates and the same genes located in autosomes in other amniotes. We report for the first time the faster evolution of Z-linked genes in a turtle (the Chinese soft-shell turtle Pelodiscus sinensis) relative to autosomal orthologs in other taxa, including turtles with temperature-dependent sex determination (TSD)...
September 27, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29036694/efficient-modulation-of-photosynthetic-apparatus-confers-desiccation-tolerance-in-the-resurrection-plant-boea-hygrometrica
#14
Tinghong Tan, Yanni Sun, Shishuai Luo, Chao Zhang, Huapeng Zhou, Honghui Lin
Boea hygrometrica (B. hygrometrica) can tolerate severe desiccation and resume photosynthetic activity rapidly upon water availability. However, little is known about the mechanisms by which B. hygrometrica adapts to dehydration and resumes competence upon rehydration. Here we determined how B. hygrometrica to deal with oxidative stress, excessive excitation/electron pressures as well as photosynthetic apparatus modulation during dehydration/rehydration. By measuring ROS generation and scavenging efficiency, we found that B...
September 19, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29036681/intra-specific-trends-of-lumen-and-wall-resistivities-of-vessels-within-the-stem-xylem-vary-among-three-woody-plants
#15
Hiroki Ooeda, Ichiro Terashima, Haruhiko Taneda
Water flow through xylem vessels encounters hydraulic resistance when passing through the vessel lumen and end wall. Comparative studies have reported that lumen and end wall resistivities co-limit water flow through stem xylem in several angiosperm woody species that have vessels of different average diameter and length. This study examined the intra-specific relationship between the lumen and end wall resistivities (Rlumen and Rwall) for vessels within the stem xylem using three deciduous angiosperm woody species found in temperate forest...
September 23, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29036632/mapping-compulsivity-in-the-dsm-5-obsessive-compulsive-and-related-disorders-cognitive-domains-neural-circuitry-and-treatment
#16
Naomi A Fineberg, Annemieke M Apergis-Schoute, M Matilde Vaghi, Paula Banca, Claire M Gillan, Valerie Voon, Samuel R Chamberlain, Cinosi Eduardo, Reid Jemma, Sonia Shahper, Edward T Bullmore, Barbara J Sahakian, Trevor W Robbins
Compulsions are repetitive, stereotyped thoughts and behaviors designed to reduce harm. Growing evidence suggests that the neurocognitive mechanisms mediating behavioural inhibition (motor inhibition, cognitive inflexibility) reversal learning and habit formation (shift from goal-directed to habitual responding) contribute toward compulsive activity in a broad range of disorders. In obsessive compulsive disorder (OCD), distributed network perturbation appears focussed around the pre-frontal cortex, caudate, putamen and associated neuro-circuitry...
September 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29036608/insights-into-rna-polymerase-catalysis-and-adaptive-evolution-gained-from-mutational-analysis-of-a-locus-conferring-rifampicin-resistance
#17
Olga Yurieva, Vadim Nikiforov, Vadim Nikiforov, Michael O'Donnell, Arkady Mustaev
S531 of Escherichia coli RNA polymerase (RNAP) β subunit is a part of RNA binding domain in transcription complex. While highly conserved, S531 is not involved in interactions within the transcription complex as suggested by X-ray analysis. To understand the basis for S531 conservation we performed systematic mutagenesis of this residue. We find that the most of the mutations significantly decreased initiation-to-elongation transition by RNAP. Surprisingly, some changes enhanced the production of full-size transcripts by suppressing abortive loss of short RNAs...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036592/gain-and-loss-of-small-rna-classes-characterization-of-small-rnas-in-the-parasitic-nematode-family-strongyloididae
#18
Anja Holz, Adrian Streit
The nematode family Strongyloididae is of particular interest because it contains important parasites of medical and veterinary relevance. In addition, species of this family can form parasitic and free-living generations and it also occupies an interesting phylogenetic position within the nematodes. Nematodes differ in several ways from other taxa with respect to their small non-coding RNAs. Recent comparative studies revealed that there is also considerable variability within the nematodes. However, no Strongyloididae species or close relative was included in these studies...
September 25, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29036575/peptides-of-the-variable-igg-domain-as-potential-biomarker-candidates-in-primary-open-angle-glaucoma-poag
#19
Carsten Schmelter, Natarajan Perumal, Sebastian Funke, Katharina Bell, Norbert Pfeiffer, Franz H Grus
Autoantibody profiling has gained increasing interest in the research field of glaucoma promising the detection of highly specific and sensitive marker candidates for future diagnostic purposes. Recent studies demonstrated that immune responses are characterized by the expression of congruent or similar complementarity determining regions (CDR) in different individuals and could be used as molecular targets in biomarker discovery. Main objective of this study was to characterize glaucoma-specific peptides from the variable region of sera-derived immunoglobulins using liquid chromatography - mass spectrometry (LC-MS) - based quantitative proteomics...
September 22, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036557/standardizing-biomass-reactions-and-ensuring-complete-mass-balance-in-genome-scale-metabolic-models
#20
Siu H J Chan, Jingyi Cai, Lin Wang, Margaret N Simons-Senftle, Costas D Maranas
Motivation: In a genome-scale metabolic model, the biomass produced is defined to have a molecular weight (MW) of 1 g mmol -1 . This is critical for correctly predicting growth yields, contrasting multiple models and more importantly modeling microbial communities. However, the standard is rarely verified in the current practice and the chemical formulae of biomass components such as proteins, nucleic acids and lipids are often represented by undefined side groups (e.g. X, R). Results: We introduced a systematic procedure for checking the biomass weight and ensuring complete mass balance of a model...
July 14, 2017: Bioinformatics
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