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https://www.readbyqxmd.com/read/29245185/contribution-of-crop-model-structure-parameters-and-climate-projections-to-uncertainty-in-climate-change-impact-assessments
#1
Fulu Tao, Reimund P Rötter, Taru Palosuo, C G H Díaz-Ambrona, M Inés Mínguez, Mikhail A Semenov, Kurt Christian Kersebaum, Claas Nendel, Xenia Specka, Holger Hoffmann, Frank Ewert, Anaelle Dambreville, Pierre Martre, Lucía Rodríguez, Margarita Ruiz-Ramos, Thomas Gaiser, Jukka G Höhn, Tapio Salo, Roberto Ferrise, Marco Bindi, Davide Cammarano, Alan H Schulman
Climate change impact assessments are plagued with uncertainties from many sources, such as climate projections or the inadequacies in structure and parameters of the impact model. Previous studies tried to account for the uncertainty from one or two of these. Here, we developed a triple-ensemble probabilistic assessment using seven crop models, multiple sets of model parameters, and eight contrasting climate projections together to comprehensively account for uncertainties from these three important sources...
December 15, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29245183/increased-expression-and-modulated-regulatory-activity-of-co-inhibitory-receptors-pd-1-tigit-and-tim-3-in-lymphocytes-of-systemic-sclerosis-patients
#2
Michelle Fleury, Anna C Belkina, Elizabeth A Proctor, Christopher Zammitti, Robert W Simms, Douglas A Lauffenburger, Jennifer E Snyder-Cappione, Robert Lafyatis, Hans Dooms
OBJECTIVE: Immune dysfunction is an important component of the disease process underlying Systemic Sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. Here, we measured the expression and function of the co-inhibitory receptors (co-IRs) PD-1, TIGIT, TIM-3, and LAG-3 in lymphocyte subsets from the peripheral blood of SSc patients. METHODS: Co-IR expression levels on immune cell subsets were analyzed using a 16-color flow cytometry panel...
December 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29245167/-are-we-really-as-happy-as-we-think-we-are-a-critical-examination-of-work-satisfaction-in-a-university-pediatric-hospital
#3
Andreas Hiemisch, Yve Stöbel-Richter, Gesine Grande, Elmar Brähler, Wieland Kiess
Goals Despite numerous reported deficits and an increasingly tense working environment in German hospitals, employees themselves often assess their job satisfaction as being high to very high. Hence, the board of directors does not have important arguments for sustainable improvement of working conditions. This discrepancy between working conditions and subjective satisfaction was the motivation for this work. Methods Data were acquired via an attitude survey at the University Hospital for Children and Adolescents Leipzig, with employees sub-divided into medical, nursing and administrative/technical staff...
December 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29245119/dceus-based-focal-parametric-perfusion-imaging-of-microvessel-with-single-pixel-resolution-and-high-contrast
#4
Diya Wang, Mengnan Xiao, Hong Hu, Yu Zhang, Zhe Su, Shanshan Xu, Yujin Zong, Mingxi Wan
This study aimed to develop a focal microvascular contrast-enhanced ultrasonic parametric perfusion imaging (PPI) scheme to overcome the tradeoff between the resolution, contrast, and accuracy of focal PPI in the tumor. Its resolution was limited by the low signal-to-clutter ratio (SCR) of time-intensity-curves (TICs) induced by multiple limitations, which deteriorated the accuracy and contrast of focal PPI. The scheme was verified by the in-vivo perfusion experiments. Single-pixel TICs were first extracted to ensure PPI with the highest resolution...
December 2, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29245052/optical-molecular-imaging-for-tumor-detection-and-image-guided-surgery
#5
REVIEW
Chensu Wang, Zhaohui Wang, Tian Zhao, Yang Li, Gang Huang, Baran D Sumer, Jinming Gao
We have witnessed rapid development of fluorescence molecular imaging of solid tumors for cancer diagnosis and image-guided surgery in the past decade. Many biomarkers unique to cancer cells or tumor microenvironment, such as cell surface receptors, hypoxia, secreted proteases and extracellular acidosis have been characterized, and can be used to distinguish cancer from normal tissue. A variety of optical imaging probes have been developed to target these biomarkers to improve tumor contrast over the background tissue...
December 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/29245049/effects-of-priming-with-cytokines-on-intracellular-survival-and-replication-of-rhodococcus-equi-in-equine-macrophages
#6
Londa J Berghaus, Steeve Giguère, Angela I Bordin, Noah D Cohen
Rhodococcus equi is a common cause of pneumonia in foals and an opportunistic pathogen in immunosuppressed people. The ability of R. equi to survive and replicate in macrophages is the basis of its pathogenicity. Limited knowledge about the role of cytokines in host defense against R. equi comes from studies in mice and the role of cytokines in intracellular survival of R. equi in equine macrophages is unknown. The objectives of this study were to determine the effect of priming with interferon (IFN)-γ, interleukin (IL)-1β, IL-4, IL-6, IL-10, or tumor necrosis factor (TNF)-α at various concentrations on intracellular survival of virulent R...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29245033/response-of-detoxification-system-genes-on-chironomus-riparius-aquatic-larvae-after-antibacterial-agent-triclosan-exposures
#7
Pedro Martínez-Paz
Triclosan (TCS) is an antimicrobial agent used in a range of personal care and consumer products and is commonly detected in aquatic ecosystems. In the present study, the effects of TCS at the molecular level on the detoxification system of Chironomus riparius aquatic larvae, a test organism widely used for the assessment of aquatic toxicology, were evaluated. The obtained results show that this xenobiotic was able to induce significant changes in transcripts from different cytochrome P450s and glutathione s-transferases genes, involved in phase I and phase II of detoxification system, respectively...
December 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29244949/growth-kinetics-and-size-distribution-dynamics-of-viscous-secondary-organic-aerosol
#8
Rahul A Zaveri, John E Shilling, Alla Zelenyuk, Jiumeng Liu, David M Bell, Emma L D'Ambro, Cassandra J Gaston, Joel A Thornton, Alexander Laskin, Peng Lin, Jacqueline M Wilson, Richard C Easter, Jian Wang, Allan K Bertram, Scot T Martin, John H Seinfeld, Douglas R Worsnop
Low bulk diffusivity inside viscous semisolid atmospheric secondary organic aerosol (SOA) can prolong equilibration timescale, but its broader impacts on aerosol growth and size distribution dynamics are poorly understood. Here we present quantitative insights into the effects of bulk diffusivity on the growth and evaporation kinetics of SOA formed under dry conditions from photooxidation of isoprene in the presence of a bimodal aerosol consisting of Aitken (ammonium sulfate) and accumulation (isoprene or -pinene SOA) mode particles...
December 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29244873/fatty-acids-in-non-alcoholic-steatohepatitis-focus-on-pentadecanoic-acid
#9
Wonbeak Yoo, Donjeta Gjuka, Heather L Stevenson, Xiaoling Song, Hong Shen, Suk Young Yoo, Jing Wang, Michael Fallon, George N Ioannou, Stephen A Harrison, Laura Beretta
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and ranges from isolated steatosis to NASH. To determine whether circulating fatty acids could serve as diagnostic markers of NAFLD severity and whether specific fatty acids could contribute to the pathogenesis of NASH, we analyzed two independent NAFLD patient cohorts and used the methionine- and choline-deficient diet (MCD) NASH mouse model. We identified six fatty acids that could serve as non-invasive markers of NASH in patients with NAFLD...
2017: PloS One
https://www.readbyqxmd.com/read/29244854/morphological-switch-to-a-resistant-subpopulation-in-response-to-viral-infection-in-the-bloom-forming-coccolithophore-emiliania-huxleyi
#10
Miguel José Frada, Shilo Rosenwasser, Shifra Ben-Dor, Adva Shemi, Helena Sabanay, Assaf Vardi
Recognizing the life cycle of an organism is key to understanding its biology and ecological impact. Emiliania huxleyi is a cosmopolitan marine microalga, which displays a poorly understood biphasic sexual life cycle comprised of a calcified diploid phase and a morphologically distinct biflagellate haploid phase. Diploid cells (2N) form large-scale blooms in the oceans, which are routinely terminated by specific lytic viruses (EhV). In contrast, haploid cells (1N) are resistant to EhV. Further evidence indicates that 1N cells may be produced during viral infection...
December 15, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29244849/nutrients-resorption-and-stoichiometry-characteristics-of-different-aged-plantations-of-larix-kaempferi-in-the-qinling-mountains-central-china
#11
Yajun Chang, Naiwei Li, Wei Wang, Xiaojing Liu, Fengfeng Du, Dongrui Yao
Elucidating the stoichiometry and resorption patterns of multiple nutrients is of essential importance to holistically understanding plant nutrition and biogeochemical cycling. Although many studies on ecological stoichiometry have been carried out, surprisingly few of them were simultaneously done on the investigation of both nutrient resorption efficiency and stoichiometry for different-aged plantations of a perennial tree. Here, both green and senesced leaf samples were collected from four Larix kaempfer plantations aged of 8, 15, 22, and 32 years in the Qinling Mountains to examine nutrients resorption efficiency and stoichiometry characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/29244835/tumor-suppressor-protein-p53-mediated-repression-of-human-mitotic-centromere-associated-kinesin-gene-expression-is-exerted-via-down-regulation-of-sp1-level
#12
Do Youn Jun, Ji Young Lee, Hae Sun Park, Yun Han Lee, Young Ho Kim
The repressive role of p53 on the human mitotic centromere-associated kinesin (MCAK) core promoter from ‒266 to +54, relative to the transcription start site, has been determined. The MCAK mRNA and protein levels were 2.1- and 3.0-fold higher, respectively, in HCT116 (p53‒/‒) than in HCT116 (p53+/+) cells. Enforced down-regulation of p53 levels either in HCT116 (p53+/+) cells by p53 RNAi treatment or in MCF-7 cells using shRNA for p53 (shp53) resulted in a remarkable increase in the MCAK protein level...
2017: PloS One
https://www.readbyqxmd.com/read/29244825/associations-of-sodium-intake-with-obesity-metabolic-disorder-and-albuminuria-according-to-age
#13
Se Won Oh, Ho Seok Koo, Kum Hyun Han, Sang Youb Han, Ho Jun Chin
Sodium intake is associated with obesity and metabolic disorder in the general population. However, sodium intake is significantly reduced according to the decrease of energy intake in older adults although the prevalence of obesity is higher than younger adults. We evaluate the association of sodium excretion (UNa) with blood pressure, obesity, metabolic disorders, and albuminuria according to age. An observational study using data from the Korean National Health and Nutrition Examination Survey IV-V (2008-2011) was performed (N = 18,146)...
2017: PloS One
https://www.readbyqxmd.com/read/29244824/a-backwards-glance-at-words-using-reversed-interior-masked-primes-to-test-models-of-visual-word-identification
#14
Colin J Davis, Stephen J Lupker
The experiments reported here used "Reversed-Interior" (RI) primes (e.g., cetupmor-COMPUTER) in three different masked priming paradigms in order to test between different models of orthographic coding/visual word recognition. The results of Experiment 1, using a standard masked priming methodology, showed no evidence of priming from RI primes, in contrast to the predictions of the Bayesian Reader and LTRS models. By contrast, Experiment 2, using a sandwich priming methodology, showed significant priming from RI primes, in contrast to the predictions of open bigram models, which predict that there should be no orthographic similarity between these primes and their targets...
2017: PloS One
https://www.readbyqxmd.com/read/29244814/forecasting-influenza-like-illness-dynamics-for-military-populations-using-neural-networks-and-social-media
#15
Svitlana Volkova, Ellyn Ayton, Katherine Porterfield, Courtney D Corley
This work is the first to take advantage of recurrent neural networks to predict influenza-like illness (ILI) dynamics from various linguistic signals extracted from social media data. Unlike other approaches that rely on timeseries analysis of historical ILI data and the state-of-the-art machine learning models, we build and evaluate the predictive power of neural network architectures based on Long Short Term Memory (LSTMs) units capable of nowcasting (predicting in "real-time") and forecasting (predicting the future) ILI dynamics in the 2011 - 2014 influenza seasons...
2017: PloS One
https://www.readbyqxmd.com/read/29244804/conditional-knockout-mice-for-the-distal-appendage-protein-cep164-reveal-its-essential-roles-in-airway-multiciliated-cell-differentiation
#16
Saul S Siller, Himanshu Sharma, Shuai Li, June Yang, Yong Zhang, Michael J Holtzman, Wipawee Winuthayanon, Holly Colognato, Bernadette C Holdener, Feng-Qian Li, Ken-Ichi Takemaru
Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport. Despite their clear importance to human biology and health, the molecular mechanisms underlying multiciliated cell differentiation are poorly understood. Prior studies implicate the distal appendage/transition fiber protein CEP164 as a central regulator of primary ciliogenesis; however, its role in multiciliogenesis remains unknown...
December 15, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29244788/dual-modulation-of-human-hepatic-zonation-via-canonical-and-non-canonical-wnt-pathways
#17
Laura McEnerney, Kara Duncan, Bo-Ram Bang, Sandra Elmasry, Meng Li, Toshio Miki, Sadeesh K Ramakrishnan, Yatrik M Shah, Takeshi Saito
The hepatic lobule is divided into three zones along the portal-central vein axis. Hepatocytes within each zone exhibit a distinctive gene expression profile that coordinates their metabolic compartmentalization. The zone-dependent heterogeneity of hepatocytes has been hypothesized to result from the differential degree of exposure to oxygen, nutrition and gut-derived toxins. In addition, the gradient of Wnt signaling that increases towards the central vein seen in rodent models is believed to play a critical role in shaping zonation...
December 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29244728/transcriptome-analysis-of-paraburkholderia-phymatum-under-nitrogen-starvation-and-during-symbiosis-with-phaseolus-vulgaris
#18
Martina Lardi, Yilei Liu, Gabriela Purtschert, Samanta Bolzan de Campos, Gabriella Pessi
Paraburkholderia phymatum belongs to the β-subclass of proteobacteria. It has recently been shown to be able to nodulate and fix nitrogen in symbiosis with several mimosoid and papilionoid legumes. In contrast to the symbiosis of legumes with α-proteobacteria, very little is known about the molecular determinants underlying the successful establishment of this mutualistic relationship with β-proteobacteria. In this study, we performed an RNA-sequencing (RNA-seq) analysis of free-living P. phymatum growing under nitrogen-replete and -limited conditions, the latter partially mimicking the situation in nitrogen-deprived soils...
December 15, 2017: Genes
https://www.readbyqxmd.com/read/29244673/using-double-contrast-ct-arthrography-to-confirm-suspected-dissociation-of-a-cemented-polyethylene-liner-in-the-setting-of-revision-total-hip-arthroplasty-a-case-report
#19
Aakash Chauhan, Sean Fitzpatrick, Robert L Sciulli, Nicholas G Sotereanos, Jeffrey J Sewecke
CASE: A 67-year-old woman who underwent a re-revision of a total hip arthroplasty with a cemented polyethylene liner fell 14 months after surgery. The patient had symptoms of pain and weakness; however, clinical, laboratory, and radiographic evaluation did not disclose fracture, infection, osteolysis, or component migration. Liner dissociation was suspected, and a double-contrast computed tomography (CT) arthrogram confirmed failure at the cement-liner interface. She underwent additional revision surgery and was doing well at the 3-year follow-up...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244642/sex-sleep-deprivation-and-the-anxious-brain
#20
Andrea N Goldstein-Piekarski, Stephanie M Greer, Jared M Saletin, Allison G Harvey, Leanne M Williams, Matthew P Walker
Insufficient sleep is a known trigger of anxiety. However, not everyone experiences these effects to the same extent. One determining factor is sex, wherein women experience a greater anxiogenic impact in response to sleep loss than men. However, the underlying brain mechanism(s) governing this sleep-loss-induced anxiety increase, including the markedly different reaction in women and men, is unclear. Here, we tested the hypothesis that structural brain morphology in a discrete network of emotion-relevant regions represents one such explanatory factor...
December 15, 2017: Journal of Cognitive Neuroscience
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