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https://www.readbyqxmd.com/read/29450923/organic-zinc-and-copper-supplementation-on-antioxidant-protective-mechanism-and-their-correlation-with-sperm-functional-characteristics-in-goats
#1
M Narasimhaiah, A Arunachalam, S Sellappan, V K Mayasula, P R Guvvala, S K Ghosh, V Chandra, J Ghosh, H Kumar
Trace minerals feeding had significant effects on sperm production and fertility with better absorption and proper utilization within the body for optimum reproductive function. Several studies have shown that more influenced trace elements in the diets of animals are copper (Cu) and zinc (Zn). Bucks showing deficiency of this mineral might affect the quality of semen production which in turn would affect the fertility. This experiment was thus designed to test the effects of organic Cu and Zn supplementation on antioxidants enzyme activities and sperm functional attributes in fresh semen of bucks...
February 15, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29449673/the-predictive-and-prognostic-potential-of-plasma-telomerase-reverse-transcriptase-tert-rna-in-rectal-cancer-patients
#2
Enrica Rampazzo, Paola Del Bianco, Roberta Bertorelle, Caterina Boso, Alessandro Perin, Giovanna Spiro, Francesca Bergamo, Claudio Belluco, Angela Buonadonna, Elisa Palazzari, Sara Leonardi, Antonino De Paoli, Salvatore Pucciarelli, Anita De Rossi
BACKGROUND: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable. The current study aimed to investigate the effectiveness of plasma telomerase reverse transcriptase (TERT) levels in predicting tumour response and clinical outcome. METHODS: 176 rectal cancer patients were included. Plasma samples were collected at baseline (before CRT=T0), 2 weeks after CRT was initiated (T1), post-CRT and before surgery (T2), and 4-8 months after surgery (T3) time points...
February 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29447273/molecular-epidemiology-and-drug-sensitivity-pattern-of-mycobacterium-tuberculosis-strains-isolated-from-pulmonary-tuberculosis-patients-in-and-around-ambo-town-central-ethiopia
#3
Melaku Tilahun, Gobena Ameni, Kassu Desta, Aboma Zewude, Lawrence Yamuah, Markos Abebe, Abraham Aseffa
INTRODUCTION: Tuberculosis (TB) is caused by M. tuberculosis complex and remains a major global public health problem. The epidemic remains a threat to sub-Saharan Africa, including Ethiopia, with further emergence of drug resistant TB. We investigated the drug sensitivity pattern and molecular epidemiology of mycobacterial strains isolated from pulmonary TB patients in and around Ambo town in Oromia Region, Central Ethiopia. METHODS: A cross-sectional study was conducted involving 105 consecutive new smear positive pulmonary TB patients diagnosed at Ambo Hospital and surrounding Health Centers between May 2014 and March 2015 upon informed consent...
2018: PloS One
https://www.readbyqxmd.com/read/29445858/l-thyroxine-intake-as-a-potential-risk-factor-for-the-development-of-fatigue-in-breast-cancer-patients-undergoing-chemotherapy
#4
Martina E Schmidt, Joachim Wiskemann, Theron Johnson, Nina Habermann, Andreas Schneeweiss, Karen Steindorf
PURPOSE: L-Thyroxine is one of the most commonly prescribed drugs and accordingly used by many breast cancer patients with thyroid disorders. Hence, potential interactions of chemotherapy with L-thyroxine, possibly contributing to fatigue, would be of high clinical relevance. Therefore, we investigated fatigue and underlying pathways in L-thyroxine-using breast cancer patients during chemotherapy. METHODS: Thyroid-stimulating hormone (TSH), L-triiodothyronine (T3), and diurnal salivary cortisol patterns were analyzed in breast cancer patients in the beginning and at the end of adjuvant chemotherapy within the control group (n = 41) of a randomized exercise intervention trial...
February 14, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29445518/why-do-endocrine-profiles-in-elite-athletes-differ-between-sports
#5
Peter H Sönksen, Richard I G Holt, Walailuck Böhning, Nishan Guha, David A Cowan, Christiaan Bartlett, Dankmar Böhning
Background: Endocrine profiles have been measured on blood samples obtained immediately post-competition from 693 elite athletes from 15 Olympic Sports competing at National or International level; four were subsequently excluded leaving 689 for the current analysis. Methods: Body composition was measured by bioimpedance in a sub-set of 234 (146 men and 88 women) and from these data a regression model was constructed that enabled 'estimated' lean body mass and fat mass to be calculated on all athletes...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29441909/the-effect-of-continuous-perfusion-of-esmolol-on-cardiovascular-risk-in-elderly-patients-undergoing-noncardiac-surgery
#6
X K Zhang, Q Hu, Q H Chen, W X Wang
We evaluated the effect of continuous perfusion of esmolol on cardiovascular risk during curative laparoscopic surgery for gastrointestinal cancer in elderly patients. Sixty patients with gastrointestinal cancer, aged from 60 to 80 years, were divided into an esmolol group (ES, n = 30) and a control group (NS, n = 30). ES patients were treated with esmolol at a dose of 0.3 mg/kg 3 min before tracheal intubation, and received continuous perfusion of esmolol at a dose of 50 μg/kg/min during operation. In NS, esmolol was replaced by saline...
August 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440950/relationship-between-etanercept-and-thyroid-function-in-patients-with-psoriasis-vulgaris
#7
Iulia Ioana Roman, Teodora Mocan, Meda-Sandra Orasan, Elena Mihaela Jianu, Carmen-Angela Sfrangeu, Remus-Ioan Orasan
Background and aim: Psoriasis vulgaris, a chronic inflammatory skin disease, requires a long term medication, in order to avoid relapsing episodes. TNF-alpha, one of the targeted molecule in psoriasis therapy, seems to be also involved in thyroid disorders etiopathogenesis. The aim of this study was to evaluate the relationship between anti TNF-alpha therapy and thyroid parameters: serum level of triiodothyronine (T3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and antithyroidperoxidase antibody (AbTPO) in psoriasis treated population...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29433971/large-scale-sequencing-of-testicular-germ-cell-tumour-tgct-cases-excludes-major-tgct-predisposition-gene
#8
Kevin Litchfield, Chey Loveday, Max Levy, Darshna Dudakia, Elizabeth Rapley, Jeremie Nsengimana, D Tim Bishop, Alison Reid, Robert Huddart, Peter Broderick, Richard S Houlston, Clare Turnbull
Testicular germ cell tumour (TGCT), the most common cancer in young men, has a significant heritable basis that has long raised questions as to the existence of underlying major high-penetrance susceptibility gene(s). To determine the contribution of rare gene mutations to the inherited risk of TGCT, we analysed germline whole-exome data for 919 TGCT cases and 1609 cancer-free controls. We compared frequencies between TGCT cases and controls of rare (<1%) and low-frequency (1-5%) coding variants (1) individually and (2) collapsed at the gene level via burden testing (T1, disruptive; T2, all deleterious; and T3, all nonsynonymous) using Fisher's exact test with Bonferroni correction of significance thresholds...
February 9, 2018: European Urology
https://www.readbyqxmd.com/read/29432604/artificial-light-and-biological-responses-of-broiler-chickens-dose-response
#9
Yefeng Yang, Chenghao Pan, Renhai Zhong, Jinming Pan
Light intensity is an important aspect for broiler production. However, previous results do not provide a solid scientific basis for quantifying the response of broilers to light intensity. This study performed a meta-analysis to model the response of broilers to 0.1 - 200 lux of light intensity. Meta-analysis was used to integrate smaller studies and increase the statistical power over that of any single study and explore new hypotheses. The results indicated that light intensity < 5 lux caused welfare concern (P < 0...
February 8, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29428520/stress-and-symptoms-of-depression-in-fathers-of-infants-admitted-to-the-nicu
#10
Helen Cyr-Alves, Lynn Macken, Kristiina Hyrkas
OBJECTIVE: To describe perceived stress and symptoms of depression in fathers of infants admitted to the NICU through 2 months after discharge and to explore associations between fathers' childhoods and current relationships with their own parents and their stress and symptoms of depression. DESIGN: Observational, longitudinal. SETTING: Tertiary care center in northeastern United States. PARTICIPANTS: English-speaking fathers of newborns admitted to the NICU...
February 8, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29427633/estimation-of-energetic-condition-in-wild-baboons-using-fecal-thyroid-hormone-determination
#11
Laurence R Gesquiere, Mya Pugh, Susan C Alberts, A Catherine Markham
Understanding how environmental and social factors affect reproduction through variation in energetic condition remains understudied in wild animals, in large part because accurately and repeatedly measuring energetic condition in the wild is a challenge. Thyroid hormones (THs), such as triiodothyronine (T3) and thyroxine (T4), have a key role in mitigating metabolic responses to energy intake and expenditure, and therefore are considered important biomarkers of an animal's energetic condition. Recent method development has shown that T3 and T4 metabolites can be measured in feces, but studies measuring THs in wild populations remain rare...
February 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29426854/association-between-plasma-cortisol-and-death-or-vasopressor-refractory-hypotension-in-preterm-neonates-a-prospective-cohort-study
#12
Monisha Rameshbabu, Venkataseshan Sundaram, Naresh Sachdeva, Rama Walia, Shiv Sajan Saini, Sourabh Dutta
OBJECTIVES: Temporal relation between adrenal insufficiency and hypotension is poorly understood. We examined the association between basal and post-stimulation cortisol and death or vasopressor refractory hypotension in preterm neonates. STUDY DESIGN: Prospective cohort study in ≤30 weeks' and/or <1,250 g weight. Primary outcome-composite of death or vasopressor refractory hypotension by day 14 of life. Plasma cortisol levels were measured at 24-36 h (T1), 72-84 h (T2) and 10 days (T3), and post-stimulation cortisol at T1 and later at T2 and T3 if the adrenal response was inadequate earlier...
February 9, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29426025/a-cross-sectional-study-of-urinary-phthalates-phenols-and-perchlorate-on-thyroid-hormones-in-us-adults-using-structural-equation-models-nhanes-2007-2008
#13
Jennifer Przybyla, G John Geldhof, Ellen Smit, Molly L Kile
BACKGROUND: Biomonitoring data shows that people are exposed to phthalates, phenols and perchlorates. Many of these compounds are endocrine disrupting compounds that affect thyroid hormone levels. Yet the effect of these compounds on thyroid hormone levels are often evaluated individually rather than as a mixture. Our objective was to examine the association between 11 urinary endocrine disrupting compounds and thyroid hormones using structural equation models. METHODS: Using data from the National Health and Nutrition and Examination Survey 2007-2008, we fit a latent variable utilizing urinary measurements of 9 compounds in females (perchlorate, bisphenol A, benzophenone-3, mono-2ethyl5carboxypentyl phthalate, mono-n-butyl phthalate, mono-(3-carboxypropyl) phthalate, mono(2ethyl5hydroxyhexyl) phthalate, mono-benzyl phthalate, and mono-isobutyl phthalate) and 8 compounds in males (without benzophenone-3)...
February 6, 2018: Environmental Research
https://www.readbyqxmd.com/read/29424670/the-impact-of-posttraumatic-stress-symptoms-on-social-support-and-social-conflict-during-hematopoietic-stem-cell-transplant
#14
James I Gerhart, Yasmin Asvat, Teresa A Lillis, Henry Fung, Johanna Grosse, Stevan E Hobfoll
PURPOSE/OBJECTIVES: Social support and its relationship to psychological distress are of interest in hematopoietic stem cell transplant (HSCT) as patients are dependent on caregivers pre-, during, and posttransplant. Although social support is critical for managing stress and trauma, posttraumatic stress symptoms (PTSS) may erode social support and evoke conflict and abandonment within the support system. This study aimed to evaluate whether PTSS were associated with lower support and social conflict in a sample of patients undergoing HSCT...
February 9, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29422493/impact-of-drinking-water-fluoride-on-human-thyroid-hormones-a-case-control-study
#15
Zohreh Kheradpisheh, Masoud Mirzaei, Amir Hossein Mahvi, Mehdi Mokhtari, Reyhane Azizi, Hossein Fallahzadeh, Mohammad Hassan Ehrampoush
The elevated fluoride from drinking water impacts on T3, T4 and TSH hormones. The aim was study impacts of drinking water fluoride on T3, T4 and TSH hormones inYGA (Yazd Greater Area). In this case- control study 198 cases and 213 controls were selected. Fluoride was determined by the SPADNS Colorimetric Method. T3, T4 and TSH hormones tested in the Yazd central laboratory by RIA (Radio Immuno Assay) method. The average amount of TSH and T3 hormones based on the levels of fluoride in two concentration levels 0-0...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29417848/triiodothyronine-stimulates-vegf-expression-and-secretion-via-steroids-and-hif-1%C3%AE-in-murine-leydig-cells
#16
Bodhana Dhole, Surabhi Gupta, Senthil Kumar Venugopal, Anand Kumar
Leydig cells are the principal steroidogenic cells of the testis. Leydig cells also secrete a number of growth factors including vascular endothelial growth factor (VEGF) which has been shown to regulate both testicular steroidogenesis and spermatogenesis. The thyroid hormone, T3, is known to stimulate steroidogenesis in Leydig cells. T3 has also been shown to stimulate VEGF production in a variety of cell lines. However, studies regarding the effect of T3 on VEGF synthesis and secretion by the Leydig cells were lacking...
February 8, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29417398/effects-of-central-fgf21-infusion-on-the-hypothalamus-pituitary-thyroid-axis-and-energy-metabolism-in-rats
#17
Umit Yilmaz, Suat Tekin, Mehmet Demir, Yilmaz Cigremis, Suleyman Sandal
The aim of this study was to evaluate the impact of intracerebroventricular chronic fibroblast growth factor 21 (FGF21) infusion on hypothalamic-pituitary-thyroid (HPT) axis, energy metabolism, food intake and body weight. Thirty male Wistar albino rats were used and divided into three groups including control, sham (vehicle) and FGF21 infused groups (n = 10). Intracerebroventricularly, FGF21 and vehicle groups were infused for 7 days with FGF21 (0.72 µg/day) and artificial cerebrospinal fluid, respectively...
February 7, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29416658/frizzled-10-and-cancer-progression-is-it-a-new-prognostic-marker
#18
Maria Principia Scavo, Livia Fucci, Lucia Caldarola, Anita Mangia, Amalia Azzariti, Giovanni Simone, Giampietro Gasparini, Silke Krol
Frizzled (FZD) proteins, a family of Wnt receptors, are involved in carcinogenesis in different organs. One interesting FZD protein is FZD-10 highly expressed in embryogenesis but completely absent in the membrane or cytosol of healthy proliferated cells. We studied in detail the expression level and the location of Frizzled-10 protein in different cancerous tissues, such as colon, melanoma and gastric cancer and in function of different staging of the tumor and in metastases. We observed a correlation between cancer evolution and FZD-10 expression, and localization of protein during carcinogenesis...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29412378/evaluation-of-the-effects-of-a-diabetes-educational-program-a-randomized-clinical-trial
#19
Heloísa de Carvalho Torres, Ana Emília Pace, Fernanda Figueredo Chaves, Gustavo Velasquez-Melendez, Ilka Afonso Reis
OBJECTIVE: Evaluate the effectiveness of a diabetes mellitus educational program in primary health care. METHODS: This cluster randomized trial was conducted in a sample of 470 people with type 2 diabetes mellitus from eight health units, randomly assigned to two groups: intervention (n = 231) and control (n = 239). The intervention group participated in the educational program composed of three strategies: group education, home visit, and telephone intervention...
February 5, 2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29412230/protective-effect-of-dexmedetomidine-against-myocardial-ischemia-reperfusion-injury-in-rabbits
#20
Jianjun Ren, Changfa Li, Yan Liu, Haitao Liu, Zhenming Dong
PURPOSE: To investigate the influence of dexmedetomidine on myocardial ischemia-reperfusion injury (IRI) in rabbits. METHODS: Twenty-four New Zealand white rabbits were randomly divided into two equal-sized groups: IRI group (group IR) and dexmedetomidine group (group D). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular diastolic pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax were recorded and calculated at the following time points: before (T0) and after (T1) dexmedetomidine infusion, after 30-min ischemia (T2), and after 120-min reperfusion (T3)...
January 2018: Acta Cirúrgica Brasileira
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