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https://www.readbyqxmd.com/read/29933123/the-effect-of-upper-instrumented-vertebra-level-on-cervical-sagittal-alignment-in-lenke-1-adolescent-idiopathic-scoliosis
#1
Ismail Emre Ketenci, Hakan Serhat Yanik, Sevki Erdem
BACKGROUND: This study aimed to evaluate the relationship between upper instrumented vertebra (UIV) level and cervical sagittal alignment (CSA) in Lenke 1 adolescent idiopathic scoliosis (AIS) patients, treated with posterior instrumentation. The hypothesis was that higher level of UIV would cause decreased cervical lordosis. METHODS: 63 Lenke 1 AIS patients that underwent posterior fusion with pedicle screw instrumentation were retrospectively evaluated. Patients were divided into three groups according to UIV level (T2, T3, T4)...
June 19, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29930520/a-randomized-controlled-trial-on-the-efficacy-of-a-psychosocial-behavioral-intervention-to-improve-the-lifestyle-of-patients-with-severe-mental-disorders-study-protocol
#2
Gaia Sampogna, Andrea Fiorillo, Mario Luciano, Valeria Del Vecchio, Luca Steardo, Benedetta Pocai, Marina Barone, Mario Amore, Francesca Pacitti, Liliana Dell'Osso, Giorgio Di Lorenzo, Mario Maj
Patients with severe mental disorders die on average 20 years prior to the general population. This mortality gap is mainly due to the higher prevalence of physical diseases and the adoption of unhealthy lifestyle behaviors.The LIFESTYLE trial aims to evaluate the efficacy of a new psychosocial group intervention (including psychoeducational, motivational, and problem-solving techniques) focused on healthy lifestyle behavior compared to a brief educational group intervention in a community sample of patients with severe mental disorders...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29929471/higher-levels-of-thyroxine-may-predict-a-favorable-response-to-donepezil-treatment-in-patients-with-alzheimer-disease-a-prospective-case-control-study
#3
Yu San Chang, Yu Hsuan Wu, Chin Jen Wang, Shu Hui Tang, Hsiang Lan Chen
BACKGROUND: Cholinergic hypothesis has been advanced as an etiology of Alzheimer disease (AD) on the basis of the presynaptic deficit found in the diseased brains, and cholinesterase inhibitors (ChEIs) are the treatment of choice for these patients. However, only about half of treatment efficacy was found. Because increasing evidence supports an extensive interrelationship between thyroid hormones (THs), cortisol level and the cholinergic system, the aim of the present study was to evaluate thyroid function and cortisol level in patients with mild to moderate AD before and after ChEIs treatment, and to identify possible variations in response...
June 22, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29923358/improving-effects-of-dietary-rumen-protected-%C3%AE-aminobutyric-acid-additive-on-apparent-nutrient-digestibility-growth-performance-and-health-status-in-heat-stressed-beef-cattle
#4
Kun Guo, Huabin Cao, Yuanjun Zhu, Tiancheng Wang, Guoliang Hu, Bunlue Kornmatitsuk, Junrong Luo
This study was aimed to investigate the effects of rumen-protected γ-aminobutyric acid (RP-GABA) on apparent nutrient digestibility, growth performance and health status in heat stressed beef cattle. Fifty Jinjiang Yellow cattle were randomly assigned to 5 treatments (10 animals/treatment). Treatments 1 to 5 were basal diets affixed with 0 (control), 8, 16, 24 and 32 mg of RP-GABA/kg of body weight (BW) respectively. The trial lasted 45 days. Apparent digestibility of crude protein (CP), crude fiber (CF) and calcium (Ca) quadratically increased with increasing RP-GABA (p < ...
June 20, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29923189/the-new-8th-edition-of-tnm-staging-and-its-implications-for-skin-cancer-a-review-by-the-british-association-of-dermatologists-and-the-royal-college-of-pathologists-united-kingdom
#5
REVIEW
S G Keohane, C M Proby, C Newlands, R J Motley, I Nasr, M F Mohd Mustapa, D N Slater
The 8th edition of TNM (Tumour, Node and Metastasis) has numerous and important changes compared to the 7th edition. Public Health England (PHE) and the Royal College of Pathologists, United Kingdom (RCPath) have adopted the 8th edition of TNM (TNM8) published by the Union for International Cancer Control (UICC) for skin cancer staging. These changes will have an impact on the management of both non-melanoma and melanoma skin cancer by all members of the skin cancer multidisciplinary team. These will also need to be highlighted to commissioners and managers for appropriate service planning...
June 19, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29922389/seasonal-body-composition-variation-amongst-elite-european-professional-soccer-players-an-approach-of-talent-identification
#6
Adam Lee Owen, Carlos Lago-Peñas, Gordon Dunlop, Rouissi Mehdi, Moktar Chtara, Alexandre Dellal
The primary aim of the investigation was to study the seasonal changes in body composition in elite European soccer players and identify key playing positional differences. Twenty-two players (age = 24 ± 3.7 years, body height = 180.45 ± 5.12 cm, body mass = 76.66 ± 5.34 kg) were tested. Players' mass (kg), lean body mass (LBM), fat free mass (FFM), fat mass (FM), muscle girths (MG) and sum of 8 skinfolds (mm) were measured across 5 time points (T0 = Start of pre-season training; T1 = End of pre-season training; T2 = Mid-season; T3 = End of mid-season break; T4 = End of season)...
June 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29915579/cytokine-secretion-and-pyroptosis-of-thyroid-follicular-cells-mediated-by-enhanced-nlrp3-nlrp1-nlrc4-and-aim2-inflammasomes-are-associated-with-autoimmune-thyroiditis
#7
Qingling Guo, Ying Wu, Yuanyuan Hou, Yongping Liu, Tingting Liu, Hao Zhang, Chenling Fan, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Background: Inflammasomes, which mediate maturation of interleukin-1β (IL-β) and interleukin-18 (IL-18) and lead to pyroptosis, have been linked to various autoimmune disorders. This study investigated whether they are involved in the pathogenesis of autoimmune thyroiditis (AIT). Methods: We collected thyroid tissues from 50 patients with AIT and 50 sex- and age-matched controls. Serum levels of free T3, free T4, thyrotropin, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured by electrochemiluminescent immunoassays...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29914512/utilization-of-adipocyte-derived-lipids-and-enhanced-intracellular-trafficking-of-fatty-acids-contribute-to-breast-cancer-progression
#8
Dejuan Yang, Yunhai Li, Lei Xing, Yiqing Tan, Jiazheng Sun, Beilei Zeng, Tingxiu Xiang, Jinxiang Tan, Guosheng Ren, Yuanyuan Wang
BACKGROUND: To determine whether adipocyte-derived lipids could be transferred into breast cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty acid trafficking in breast cancer cells. METHODS: A Transwell co-culture system was used in which human breast cancer cells were cultured in the absence or presence of differentiated murine 3 T3-L1 adipocytes. Migration/invasion and proliferation abilities were compared between breast cancer cells that were cultivated alone and those co-cultivated with mature adipocytes...
June 18, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29910832/phase-i-ii-study-on-kilovoltage-surface-brachytherapy-in-conjunctival-cancer-preliminary-results
#9
Gustavo R Sarria, Gustavo J Sarria, Paola Fuentes Rivera, Mayer Zaharia, Solón Serpa, Mario Buitrago
Introduction: In ocular conjunctival carcinoma after surgery, adjuvant treatment has a role and kilovoltage surface brachytherapy opens a new door for the range of therapeutic options. Materials and methods: Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. The portable accelerator of 50-kV INTRABEAM (Carl Zeiss Meditec) was used, after local anaesthesia and blocking of ocular muscles movement...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910736/thyroid-hormones-play-role-in-sarcopenia-and-myopathies
#10
Flavia F Bloise, Thamires S Oliveira, Aline Cordeiro, Tania M Ortiga-Carvalho
Skeletal muscle maintains posture and enables movement by converting chemical energy into mechanical energy, further contributing to basal energy metabolism. Thyroid hormones (thyroxine, or T4, and triiodothyronine, or T3) participate in contractile function, metabolic processes, myogenesis and regeneration of skeletal muscle. T3 classically modulates gene expression after binding to thyroid hormone nuclear receptors. Thyroid hormone effects depend on nuclear receptor occupancy, which is directly related to intracellular T3 levels...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29908087/scotostimulation-of-reproductive-neural-pathways-and-gonadal-maturation-are-not-correlated-with-hypothalamic-expression-of-deiodinases-in-subtropical-spotted-munia
#11
Ila Mishra, Neha Agarwal, Sangeeta Rani, Vinod Kumar
Circannual rhythm regulates annual timing of reproduction in spotted munia, with sex-differences in its relationship with the external photoperiod environment. Interestingly, munia show an atypical photosensitivity and exhibit gonadal maturation when acutely exposed to an unnatural short photoperiod (e.g. 3 h light per day; i.e. a long scotoperiod). The proximate mechanisms regulating scotoperiod-induced hypothalamus-pituitary-gonadal (HPG) activation are unclear. Since thyroid hormone signalling plays a central role in photoperiodic induction, we hypothesized the involvement of similar mechanism, i...
June 16, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29908031/the-efficacy-of-curcumin-in-managing-acute-inflammation-pain-on-the-post-surgical-removal-of-impacted-third-molars-patients-a-randomized-controlled-trial
#12
Tantry Maulina, Hedy Diana, Arief Cahyanto, Amaliya
BACKGROUND: Curcumin is a turmeric contained active ingredient that has been proven to be effective in treating pain and inflammation due to its analgesic as well as anti-inflammation potential. Odontectomy, on the other hand, has been well known for its post-procedure acute inflammation pain. OBJECTIVE: The aim of the current study was to evaluate the efficacy of curcuminoid in treating acute inflammation post-operative pain in the post-surgical removal of impacted third molars patients...
June 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29902746/the-environmental-contaminant-tributyltin-leads-to-abnormalities-in-different-levels-of-the-hypothalamus-pituitary-thyroid-axis-in-female-rats
#13
Marcelle Novaes Andrade, Ana Paula Santos-Silva, Paula Rodrigues-Pereira, Francisca Diana Paiva-Melo, Niedson Correa de Lima Junior, Mariana Pires Teixeira, Paula Soares, Glaecir Roseni Munstock Dias, Jones Bernardes Graceli, Denise Pires de Carvalho, Andrea Claudia Freitas Ferreira, Leandro Miranda-Alves
Tributyltin is a biocide used in nautical paints, aiming to reduce fouling of barnacles in ships. Despite the fact that many effects of TBT on marine species are known, studies in mammals have been limited, especially those evaluating its effect on the function of the hypothalamus-pituitary-thyroid (HPT) axis. The aim of this study was to investigate the effects of subchronic exposure to TBT on the HPT axis in female rats. Female Wistar rats received vehicle, TBT 200 ng kg-1 BW d-1 or 1000 ng kg-1 BW d-1 orally by gavage for 40 d...
June 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29902617/the-possible-ameliorative-effect-of-olea-europaea-l-oil-against-deltamethrin-induced-oxidative-stress-and-alterations-of-serum-concentrations-of-thyroid-and-reproductive-hormones-in-adult-female-rats
#14
Fatiha Mekircha, Samira Chebab, Rosita Gabbianelli, Essaid Leghouchi
This study aimed to verify whether Olea europaea L. (olive) oil (OEO) exerted a protective effect against oxidative stress induced by deltamethrin (DM) and alterations of pituitary, thyroid and gonadal hormones in adult female rats. DM (0,00256 g/kg body weight),OEO (0,6 g/kg body weight) and DM with OEO were administered to rats orally for 28 days. Volatile compounds present in olive oil were analysed by GC-MS. Estradiol (E2 ), Thyroxine (T4),Thyroid Stimulating Hormone (TSH), Triiodothyronine (T3), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Progesterone (Pg) were measured in serum using Chemiluminescent Microparticle Immunoassay (CMIA)...
June 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29899732/3-5-diiodo-l-thyronine-increases-glucose-consumption-in-cardiomyoblasts-without-affecting-the-contractile-performance-in-rat-heart
#15
Ginevra Sacripanti, Nhat Minh Nguyen, Leonardo Lorenzini, Sabina Frascarelli, Alessandro Saba, Riccardo Zucchi, Sandra Ghelardoni
3,5-diiodo-l-thyronine (T2) is an endogenous derivative of thyroid hormone that has been suggested to regulate energy expenditure, resting metabolic rate and oxygen consumption with a mechanism that involves the activation of mitochondrial function. In this study, we focused on the cardiac effects of T2, which have been poorly investigated so far, by using both in vitro and ex vivo models. As a comparison, the response to T3 and T4 was also determined. Rat cardiomyoblasts (H9c2 cells) were used to determine T2, T3, and T4 uptake by high-performance liquid chromatography-tandem mass spectrometry...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29897547/dietary-supplemented-effects-of-mannan-oligosaccharides-on-biochemical-parameters-of-4-close-bred-flocks-of-japanese-quail-breeders
#16
M A Iqbal, N Roohi, O Khan
The current study was carried out to investigate the consequences of mannan-oligosaccharides (MOS), a prebiotic, as feed supplement on biochemical parameters of Japanese quail breeders (Coturnix coturnix japonica). Twelve-week-old, 960 birds, belonging to 4 close-bred flocks (CBF), were randomly selected and divided into 4 treatment groups with 3 replicates according to pattern (4 strains × 4 treatment groups × 3 replicates). Birds were fed corn-based basal diet or the same diet supplemented with 0.25, 0...
June 8, 2018: Poultry Science
https://www.readbyqxmd.com/read/29897528/prebiotics-offered-to-broiler-chicken-exert-positive-effect-on-meat-quality-traits-irrespective-of-delivery-route
#17
S Tavaniello, G Maiorano, K Stadnicka, R Mucci, J Bogucka, M Bednarczyk
Elimination of antibiotic growth promoters from poultry production has encouraged intensive search for relevant alternatives. Prebiotics are proposed as efficient replacements to stimulate colonization/expansion of beneficial microflora in chickens. The aim of this study was to deepen the knowledge on the effect of prebiotic administration on slaughter performance and meat quality traits of broiler chickens by evaluating different routes of their delivery (in ovo vs. in-water vs. in ovo + in-water). At d 12 of incubation, 1,500 eggs (Ross 308) containing viable embryos were randomly allotted into 4 groups and injected in ovo with 0...
April 20, 2018: Poultry Science
https://www.readbyqxmd.com/read/29896988/influence-of-hypothyroidism-on-testicular-mitochondrial-oxidative-stress-by-activating-the-p38-mitogen-activated-protein-kinase-and-c-jun-nh-2-terminal-kinase-signaling-pathways-in-rats
#18
X-R Chang, Y-L Yao, D Wang, H-T Ma, P-H Gou, C-Y Li, J-L Wang
Thyroid hormone deficiency can impair testicular function. However, knowledge of the effects of mitogen-activated protein kinase (MAPK) pathways on testicular mitochondrial oxidative damage induced by hypothyroidism is still rudimentary. This study aims to explore the possible mechanisms of testicular mitochondrial oxidative damage in hypothyroidism rats. Wistar male rats were randomly divided into control (C), low- (L), and high-hypothyroidism (H) groups (1 ml/100 g body weights (BWs)/day 0, 0.001% and 0.1% propylthiouracil, respectively) by intragastric gavage for 60 days...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29896255/therapeutic-effects-of-acupuncture-with-mok-a-polyherbal-medicine-on-ptu-induced-hypothyroidism-in-rats
#19
Ji Hye Hwang, Hyo Won Jung, Seok Yong Kang, An Na Kang, Jun Nan Ma, Xiang Long Meng, Min Sub Hwang, Yong-Ki Park
Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced in Sprague-Dawley rats by subcutaneous injection of Propylthiouracil (PTU; 10 mg/kg) once daily for 4 weeks. MOK was administered by acupuncture on the acupoints around the thyroid gland of PTU-induced hypothyroidism rats once daily for 2 weeks following hypothyroidism induction...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895698/thyroid-hormone-receptor-%C3%AE-1-stimulates-abcb4-to-increase-biliary-phosphatidylcholine-excretion-in-mice
#20
Julien Gautherot, Thierry Claudel, Frans Cuperus, Claudia Daniela Fuchs, Thomas Falguieres, Michael Trauner
The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular membrane of hepatocytes. Defective ABCB4 gene expression and protein function result in various cholestatic liver and bile duct injuries. Thyroid hormone receptor (THR) is a major regulator of hepatic lipid metabolism; we explored its potential role in ABCB4 regulation. Thyroid hormone T3 stimulation to human hepatocyte models showed direct transcriptional activation of ABCB4 in a dose- and time-dependent manner...
June 12, 2018: Journal of Lipid Research
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