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Tick borne encephalitis vaccine

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https://www.readbyqxmd.com/read/28632298/patient-med-tbe-f%C3%A3-rb%C3%A3-ttrades-snabbt-vid-behandling-med-kortison-evidens-saknas-dock-f%C3%A3-r-v%C3%A3-rdet-av-immunmodulerande-terapi
#1
Carl Wengse, Jesper Ericsson, Susanna Hallberg, Johan Ursing
Rapid improvement of tick-borne encephalitis after treatment with corticosteroids Tick-borne encephalitis (TBE) is a viral disease transmitted by ticks. The virus is divided into three subtypes named Western, Siberian and Far Eastern TBE virus (TBEV). Western TBEV is endemic in parts of Europe and Sweden and typically causes a biphasic illness with influenza-like symptoms followed by neurological symptoms ranging from mild meningitis to severe meningoencephalitis and death. Despite an effective vaccine, TBE is increasing in Sweden and Europe...
June 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28625666/a-comparative-analysis-on-the-physicochemical-properties-of-tick-borne-encephalitis-virus-envelope-protein-residues-that-affect-its-antigenic-properties
#2
Yu S Bukin, Yu P Dzhioev, S E Tkachev, I V Kozlova, A I Paramonov, D Ruzek, Z Qu, V I Zlobin
This work is dedicated to the study of the variability of the main antigenic envelope protein E among different strains of tick-borne encephalitis virus at the level of physical and chemical properties of the amino acid residues. E protein variants were extracted from then NCBI database. Four amino acid residues properties in the polypeptide sequences were investigated: the average volume of the amino acid residue in the protein tertiary structure, the number of amino acid residue hydrogen bond donors, the charge of amino acid residue lateral radical and the dipole moment of the amino acid residue...
June 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28577343/de-novo-rna-synthesis-catalyzed-by-the-zika-virus-rna-polymerase-domain
#3
Christina Calmels, Michel Ventura, Cindy Aknin, Mathieu Métifiot, Marie-Line Andreola
Mosquito- and tick-borne pathogens including Chikungunya, Dengue, Japanese encephalitis, West Nile, Yellow fever and Zika virus, represent a new economic and public health challenge. In the absence of effective vaccines and specific therapies, only supportive regimens are administrated for most of these infections. Thus, the development of a targeted therapy is mandatory to stop the rapid progression of these pathogens and preoccupant associated burdens such as Guillain-Barre syndrome, microcephaly. For this, it is essential to develop biochemical tools to help study and target key viral enzymes involved in replication such as helicase complexes, methyl-transferases and RNA-dependent RNA polymerases...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28545923/seropersistence-of-tbe-virus-antibodies-10-years-after-first-booster-vaccination-and-response-to-a-second-booster-vaccination-with-fsme-immun-0-5ml-in-adults
#4
R Konior, J Brzostek, E M Poellabauer, Q Jiang, L Harper, W Erber
Tick-borne encephalitis (TBE) is a viral disease that can have a severe acute clinical course and considerable long-term morbidity. As there is no causal treatment currently available for TBE, vaccination is the only way to combat the disease in endemic areas. The studies presented here were conducted to obtain prospective long-term TBE serum antibody persistence data of subjects up to 10years after the first booster with FSME-IMMUN. This report presents the results of 2 follow-up studies in the same study population of 315 healthy adults...
May 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28457701/primary-care-physician-management-of-tick-bites-in-the-franche-comt%C3%A3-region-eastern-france-2013
#5
C Vandererven, A-P Bellanger, J-F Faucher, P Marguet
INTRODUCTION: Tick bites, which may lead to Lyme disease, often prompt patients to consult their primary care physicians (PCPs). The aim of the present study was to assess how and how often PCPs in the Franche-Comté region of France manage tick bites. MATERIAL AND METHODS: Standardized questionnaires were sent to a random sample of 400 PCPs in the Franche-Comté region, requesting their voluntary and anonymous participation. The questionnaires collected socio-demographic details and practice-related information about tick-bite prophylaxis, Lyme serology, and tick-borne encephalitis vaccination...
April 27, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28457486/vaccination-against-louping-ill-virus-protects-goats-from-experimental-challenge-with-spanish-goat-encephalitis-virus
#6
L M Salinas, R Casais, J F García Marín, K P Dalton, L J Royo, A Del Cerro, E Gayo, M P Dagleish, P Alberdi, R A Juste, J de la Fuente, A Balseiro
Spanish goat encephalitis virus (SGEV) is a recently described member of the genus Flavivirus belonging to the tick-borne encephalitis group of viruses, and is closely related to louping ill virus (LIV). Naturally acquired disease in goats results in severe, acute encephalitis and 100% mortality. Eighteen goats were challenged subcutaneously with SGEV; nine were vaccinated previously against LIV and nine were not. None of the vaccinated goats showed any clinical signs of disease or histological lesions, but all of the non-vaccinated goats developed pyrexia and 5/9 developed neurological clinical signs, primarily tremors in the neck and ataxia...
April 28, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28449731/estimating-the-annual-burden-of-tick-borne-encephalitis-to-inform-vaccination-policy-slovenia-2009-to-2013
#7
Mario Fafangel, Alessandro Cassini, Edoardo Colzani, Irena Klavs, Marta Grgič Vitek, Veronika Učakar, Marion Muehlen, Marko Vudrag, Alenka Kraigher
With an annual incidence between 8 and 15 per 100,000 population in the period from 2009 to 2013, Slovenia has one of the highest notified incidences of tick-borne encephalitis (TBE) in Europe. TBE vaccination coverage remains at about 7.3%. To inform vaccination policy, we used surveillance data from 2009 to 2013 to calculate the overall and age- and sex-specific mean annual TBE incidence. We estimated disability-adjusted life years (DALYs) with 95% uncertainty intervals (UI), using the Burden of Communicable Diseases in Europe approach from the European Centre for Disease Prevention and Control...
April 20, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28440879/tick-borne-encephalitis-in-patients-vaccinated-against-this-disease
#8
S Lotrič-Furlan, P Bogovič, T Avšič-Županc, M Jelovšek, L Lusa, F Strle
BACKGROUND: Information on tick-borne encephalitis (TBE) in patients already vaccinated against the disease is limited. OBJECTIVES: To compare the course and outcome in patients with vaccination breakthrough TBE with findings in patients who developed TBE without previous vaccination. METHODS: All adult patients diagnosed with TBE at a single medical centre during a 16-year period and who had received at least two doses of TBE vaccine before the onset of illness qualified for the study...
April 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28421031/fatal-outcome-of-european-tick-borne-encephalitis-after-vaccine-failure
#9
Parham Sendi, Cédric Hirzel, Stefan Pfister, Rahel Ackermann-Gäumann, Denis Grandgirard, Ekkehard Hewer, Arto C Nirkko
Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200-250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28341533/epidemiology-of-infectious-encephalitis-causes-in-2016
#10
REVIEW
A Boucher, J L Herrmann, P Morand, R Buzelé, Y Crabol, J P Stahl, A Mailles
We performed a literature search in the Medline database, using the PubMed website. The incidence of presumably infectious encephalitis is estimated at 1.5-7 cases/100,000 inhabitants/year, excluding epidemics. Infectious encephalitis and immune-mediated encephalitis share similar clinical signs and symptoms. The latter accounts for a significant proportion of presumably infectious encephalitis cases without any established etiological diagnosis; as shown from a prospective cohort study where 21% of cases were due to an immune cause...
May 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28268073/vaccinations-in-early-life-are-not-associated-with-development-of-islet-autoimmunity-in-type-1-diabetes-high-risk-children-results-from-prospective-cohort-data
#11
Andreas Beyerlein, Andreas N Strobl, Christiane Winkler, Michaela Carpus, Annette Knopff, Ewan Donnachie, Donna P Ankerst, Anette-G Ziegler
AIMS/HYPOTHESIS: Vaccinations in early childhood potentially stimulate the immune system and may thus be relevant for the pathogenesis of autoimmune diseases such as type 1 diabetes (T1D). We determined the association of vaccination burden with T1D-associated islet autoimmunity in children with high familial risk followed prospectively from birth. METHODS: A total of 20,570 certified vaccination records from 1918 children were correlated with time to onset of T1D-associated islet autoimmunity using Cox regression, considering multiple time periods up until age two years and vaccination types, and adjusting for HLA genotype, sex, delivery mode, season of birth, preterm delivery and maternal T1D status...
March 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28221100/intracellular-degradation-and-localization-of-ns1-of-tick-borne-encephalitis-virus-affect-its-protective-properties
#12
Yulia V Kuzmenko, Elizaveta S Starodubova, Anastasia S Shevtsova, Liubov L Chernokhaeva, Anastasia A Latanova, Olga V Preobrazhenskaia, Andrey V Timofeev, Galina G Karganova, Vadim L Karpov
Currently, many DNA vaccines against infectious diseases are in clinical trials; however, their efficacy needs to be improved. The potency of DNA immunogen can be optimized by targeting technologies. In the current study, to increase the efficacy of NS1 encoded by plasmid, proteasome targeting was applied. NS1 variants with or without translocation sequence and with ornithine decarboxylase as a signal of proteasomal degradation were tested for expression, localization, protein turnover, proteasomal degradation and protection properties...
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28213810/how-to-tackle-natural-focal-infections-from-risk-assessment-to-vaccination-strategies
#13
Luca Busani, Alexander E Platonov, Onder Ergonul, Giovanni Rezza
Natural focal diseases are caused by biological agents associated with specific landscapes. The natural focus of such diseases is defined as any natural ecosystem containing the pathogen's population as an essential component. In such context, the agent circulates independently on human presence, and humans may become accidentally infected through contact with vectors or reservoirs. Some viruses (i.e., tick-borne encephalitis and Congo-Crimean hemorrhagic fever virus) are paradigmatic examples of natural focal diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28179396/the-antigenic-structure-of-zika-virus-and-its-relation-to-other-flaviviruses-implications-for-infection-and-immunoprophylaxis
#14
REVIEW
Franz X Heinz, Karin Stiasny
Zika virus was discovered ∼70 years ago in Uganda and maintained a low profile as a human disease agent in Africa and Asia. Only recently has it caused explosive outbreaks in previously unaffected regions, first in Oceania and then in the Americas since 2015. Of special concern is the newly identified link between congenital malformations (especially microcephaly) and Zika virus infections during pregnancy. At present, it is unclear whether Zika virus changed its pathogenicity or whether the huge number of infections allowed the recognition of a previously cryptic pathogenic property...
March 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28153343/tick-borne-encephalitis-in-china-a-review-of-epidemiology-and-vaccines
#15
REVIEW
Yi Xing, Heinz-Josef Schmitt, Adriano Arguedas, Junfeng Yang
Tick-borne encephalitis (TBE) has been shown to be endemic in northern and western China, including the three mountain areas in Heilongjiang, Jilin, Inner Mongolia, and Xinjiang. In addition, serology evidence shows that there is human infection in south-west provinces of China, including Xizang (Tibet) and Yunnan. TBE in China is caused by the Far Eastern TBE virus subtype and there is no biphasic course for disease presentation. The majority of TBE cases in China have occurred in people who were living or working in forests...
January 30, 2017: Vaccine
https://www.readbyqxmd.com/read/28143786/compliance-with-vaccination-against-tick-borne-encephalitis-virus-in-germany
#16
L Jacob, K Kostev
OBJECTIVES: The goal of this study was to analyse patients' compliance with vaccination against tick-borne encephalitis (TBE) virus in Germany. METHODS: The present study included 7266 patients from 638 general practices and 4194 patients from 114 paediatric practices. Patients were included if they had received the first dose of one of two vaccines against TBE virus (FSME-Immune(®) and Encepur(®)). The immunization schedule of these vaccines consisted of three injections...
July 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28077444/protein-interactions-during-the-flavivirus-and-hepacivirus-life-cycle
#17
REVIEW
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann
Protein-protein interactions govern biological functions in cells, in the extracellular milieu, and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell. Usage of host proteins by viruses can have severe consequences e.g. apoptosis, metabolic disequilibria, or altered cell proliferation and mobility. Understanding protein interactions during virus infection can thus educate us on viral infection and pathogenesis mechanisms...
April 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27875810/nonstructural-protein-1-of-tick-borne-encephalitis-virus-induces-oxidative-stress-and-activates-antioxidant-defense-by-the-nrf2-are-pathway
#18
Yulia V Kuzmenko, Olga A Smirnova, Alexander V Ivanov, Elizaveta S Starodubova, Vadim L Karpov
BACKGROUND: Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE: In the current study we explored the ability of TBEV nonstructural protein 1 (NS1) to induce oxidative stress and activate antioxidant defense via the nuclear factor (erythroid-derived-2)-like 2/antioxidant response element (Nrf2/ARE) pathway...
2016: Intervirology
https://www.readbyqxmd.com/read/27779467/travel-related-tick-borne-encephalitis-israel-2006-2014
#19
Eyal Meltzer, Yael Paran, Yaniv Lustig, Shmuel Stienlauf, Miriam Weinberger, Eli Schwartz
During 2006-2014, four tick-borne encephalitis (TBE) cases occurred among Israeli travelers. We calculated TBE incidence at 321.0, 45.0, 13.2, and 7.5 cases/100,000 travelers/year of travel to Sweden, Switzerland, Austria, and Germany, respectively. TBE incidence among travelers to these destinations appears to justify TBE vaccination in accordance with World Health Organization recommendations.
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27760182/revisiting-recombination-signal-in-the-tick-borne-encephalitis-virus-a-simulation-approach
#20
Yann J K Bertrand, Magnus Johansson, Peter Norberg
The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of work, no consensus has yet emerged on TBEV evolutionary dynamics. Understanding the occurrence and frequency of recombination in TBEV bears significant impact on epidemiology, evolution, and vaccination with live vaccines. In this study, we investigated the possibility of detecting recombination events in TBEV by simulating recombinations at several locations on the virus' phylogenetic tree and for different lengths of recombining fragments...
2016: PloS One
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