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Tick borne encephalitis vaccine

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https://www.readbyqxmd.com/read/29695688/-human-genetic-predisposition-to-diseases-caused-by-viruses-from-flaviviridae-family
#1
N S Yudin, A V Barkhash, V N Maksimov, E V Ignatieva, A G Romaschenko
The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29673942/allergic-patients-with-and-without-allergen-specific-immunotherapy-mount-protective-immune-responses-to-tick-borne-encephalitis-vaccination-in-absence-of-enhanced-side-effects-or-propagation-of-their-th2-bias
#2
Erika Garner-Spitzer, Claudia Seidl-Friedrich, Ines Zwazl, Michael Hofer, Tamar Kinaciyan, Reinhart Jarisch, Karin Stiasny, Gerhard J Zlabinger, Michael Kundi, Ursula Wiedermann
BACKGROUND: Allergic diseases are caused by Th2-driven immune responses and their treatment with specific immunotherapy (SIT) leads to immunomodulation via IL10, TGF-ß and Th1/Tr1 shift. This phase IV, open-label clinical trial investigated whether allergies and SIT treatment influenced immune responses to routine vaccination. METHODS: We studied three groups: 49 allergic patients (allergic group), 21 allergic patients receiving maintenance doses of SIT (SIT group), and 49 non-allergic controls...
May 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29576392/clinical-outcome-and-cerebrospinal-fluid-profiles-in-patients-with-tick-borne-encephalitis-and-prior-vaccination-history
#3
Thorsten Lenhard, Daniela Ott, Nurith J Jakob, Francisco Martinez-Torres, Caspar Grond-Ginsbach, Uta Meyding-Lamadé
BACKGROUND: Tick-borne encephalitis (TBE) is endemic in southern and eastern districts of Germany. Approximately 10-14% of the infected individuals suffer from long-term disability and in 1.5-3.6% the course is fatal. Two well-tolerated vaccines are available, which provide high protection and which have been confirmed in several field studies. Here we investigate clinical course, long-term outcome and cerebrospinal fluid (CSF) characteristics of TBE cases with a prior history of any vaccination as well as real vaccination breakthrough (VBT)...
March 1, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29555424/tick-borne-encephalitis-virus-in-arthropod-vectors-in-the-far-east-of-russia
#4
Natalia M Pukhovskaya, Olga V Morozova, Nelya P Vysochina, Nadejda B Belozerova, Svetlana V Bakhmetyeva, Nina I Zdanovskaya, Stephen J Seligman, Leonid I Ivanov
Isolates of tick-borne encephalitis virus (TBEV) from arthropod vectors (ticks and mosquitoes) in the Amur, the Jewish Autonomous and the Sakhalin regions as well as on the Khabarovsk territory of the Far East of Russia were studied. Different proportions of four main tick species of the family Ixodidae: Ixodes persulcatus P. Schulze, 1930; Haemaphysalis concinna Koch, 1844; Haemaphysalis japonica douglasi Nuttall et Warburton, 1915 and Dermacentor silvarum Olenev, 1932 were found in forests and near settlements...
February 8, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29511073/diagnosis-of-zika-virus-infection-by-peptide-array-and-enzyme-linked-immunosorbent-assay
#5
Nischay Mishra, Adrian Caciula, Adam Price, Riddhi Thakkar, James Ng, Lokendra V Chauhan, Komal Jain, Xiaoyu Che, Diego A Espinosa, Magelda Montoya Cruz, Angel Balmaseda, Eric H Sullivan, Jigar J Patel, Richard G Jarman, Jennifer L Rakeman, Christina T Egan, Chantal B E M Reusken, Marion P G Koopmans, Eva Harris, Rafal Tokarz, Thomas Briese, W Ian Lipkin
Zika virus (ZIKV) is implicated in fetal stillbirth, microcephaly, intracranial calcifications, and ocular anomalies following vertical transmission from infected mothers. In adults, infection may trigger autoimmune inflammatory polyneuropathy. Transmission most commonly follows the bite of infected Aedes mosquitoes but may also occur through sexual intercourse or receipt of blood products. Definitive diagnosis through detection of viral RNA is possible in serum or plasma within 10 days of disease onset, in whole blood within 3 weeks of onset, and in semen for up to 3 months...
March 6, 2018: MBio
https://www.readbyqxmd.com/read/29501619/self-reported-tick-borne-encephalitis-tbe-vaccination-coverage-in-europe-results-from-a-cross-sectional-study
#6
Wilhelm Erber, Heinz-Josef Schmitt
Adequate vaccination is effective in preventing tick-borne encephalitis (TBE). A population survey conducted in 2015 in Czech Republic, Estonia, Finland, Germany, Hungary, Latvia, Lithuania, Poland, Slovakia, Slovenia, and Sweden obtained information on TBE vaccination. Respondents answered 10 questions for themselves and household members. Data were weighted according to age and fine-tuned for geographical spread. Across the 10 countries (excluding Poland), TBE awareness was 83%; of all respondents, 68% were aware of TBE vaccines and 25% had ≥1 injections...
February 16, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29473735/the-use-of-ex-vivo-organ-cultures-in-tick-borne-virus-research
#7
Jeffrey M Grabowski, Danielle K Offerdahl, Marshall E Bloom
Each year there are more than 15 000 cases of human disease caused by infections with tick-borne viruses (TBVs). These illnesses occur worldwide and can range from very mild illness to severe encephalitis and hemorrhagic fever. Although TBVs are currently identified as neglected vector-borne pathogens and receive less attention than mosquito-borne viruses, TBVs are expanding into new regions, and infection rates are increasing. Furthermore, effective vaccines, diagnostic tools, and other countermeasures are limited...
March 9, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29435494/tick-borne-encephalitis-virus-vaccine-induced-human-antibodies-mediate-negligible-enhancement-of-zika-virus-infection-in-vitro-and-in-a-mouse-model
#8
James Duehr, Silviana Lee, Gursewak Singh, Gregory A Foster, David Krysztof, Susan L Stramer, Maria C Bermúdez González, Eva Menichetti, Robert Geretschläger, Christian Gabriel, Viviana Simon, Jean K Lim, Florian Krammer
Recent reports in the scientific literature have suggested that anti-dengue virus (DENV) and anti-West Nile virus (WNV) immunity exacerbates Zika virus (ZIKV) pathogenesis in vitro and in vivo in mouse models. Large populations of immune individuals exist for a related flavivirus (tick-borne encephalitis virus [TBEV]), due to large-scale vaccination campaigns and endemic circulation throughout most of northern Europe and the southern Russian Federation. As a result, the question of whether anti-TBEV immunity can affect Zika virus pathogenesis is a pertinent one...
January 2018: MSphere
https://www.readbyqxmd.com/read/29397225/second-five-year-follow-up-after-a-booster-vaccination-against-tick-borne-encephalitis-following-different-primary-vaccination-schedules-demonstrates-at-least-10-years-antibody-persistence
#9
Jiri Beran, Maria Lattanzi, Fang Xie, Luca Moraschini, Ilaria Galgani
BACKGROUND: Tick borne encephalitis (TBE) endemic zones are expanding. We previously evaluated long term persistence of antibody 5 years after the first booster immunization following different primary immunization schedules with the polygeline-free inactivated TBE vaccine (TBEvac) in adults and adolescents. Here, we report anti-TBE virus (TBEV) antibody persistence from 6 to 10 years post-booster administration. METHODS: This was a phase IV, open-label, single-center, second extension study (NCT01562444), conducted in Czechia...
February 1, 2018: Vaccine
https://www.readbyqxmd.com/read/29387135/vaccines-for-the-elderly-current-use-and-future-challenges
#10
REVIEW
Birgit Weinberger
Age-related changes of the immune system contribute to increased incidence and severity of infections in the elderly. Vaccination is the most effective measure to prevent infections and vaccination recommendations in most countries include specific guidelines for the elderly. Vaccination against influenza and Streptococcus pneumoniae is usually recommended for persons with underlying diseases and for the elderly with heterogeneous age limits between ≥ 50 years and ≥ 65 years. Some countries also recommend vaccination against herpes zoster...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29386094/distinction-between-serological-responses-following-tick-borne-encephalitis-virus-tbev-infection-vs-vaccination-sweden-2017
#11
Bo Albinsson, Sirkka Vene, Lars Rombo, Jonas Blomberg, Åke Lundkvist, Bengt Rönnberg
Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and neutralisation, by multiplex serology in 50 TBEV patients and 50 TBEV vaccinees. Infection induced antibodies reactive to both whole virus (WV) and non-structural protein 1 (NS1) in 48 clinical cases, whereas 47 TBEV vaccinees had WV, but not NS1 antibodies, enabling efficient discrimination of infection/vaccination...
January 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29053888/epidemiological-patterns-of-tick-borne-encephalitis-in-lithuania-and-clinical-features-in-adults-in-the-light-of-the-high-incidence-in-recent-years-a-retrospective-study
#12
D Radzišauskienė, K Žagminas, L Ašoklienė, A Jasionis, R Mameniškienė, A Ambrozaitis, L Jančorienė, D Jatužis, I Petraitytė, E Mockienė
BACKGROUND AND PURPOSE: Lithuania is one of the countries with the highest incidence of tick-borne encephalitis (TBE) in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years. METHODS: Surveillance data available on the website of the Centre for Communicable Diseases and AIDS of Lithuania were used to describe the epidemiological patterns of TBE...
February 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053401/are-we-prepared-for-emerging-flaviviruses-in-europe-challenges-for-vaccination
#13
Patricia Kaaijk, Willem Luytjes
Tick-borne encephalitis and West Nile fever are endemic flavivirus diseases in Europe. Climate change, virus evolution, and social factors may increase the risk of these flavivirus infections and may lead to the emergence of other flaviviruses in Europe that are endemic in (sub)tropical regions of the world. Control of the spread of flaviviruses is very difficult considering the cycling of flaviviruses between arthropod vectors and animal reservoir hosts. The increasing threat of flavivirus infections emphasizes the necessity of a sustainable vector surveillance system, an active animal health surveillance system and an adequate human surveillance system for early detection of flavivirus infections...
February 1, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28975470/infections-of-the-central-nervous-system-in-returning-travelers-and-immigrants
#14
REVIEW
Haley Thompson, Kiran Thakur
PURPOSE OF REVIEW: This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS: Updates on travel vaccine recommendations including vaccine-specific interactions with immunosuppressive agents, advances in Zika virus and dengue virus vaccine development, new diagnostic criteria for neurocysticercosis, updates on treatment approaches for tuberculosis meningitis...
October 3, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28928417/tick-borne-encephalitis-in-japan-republic-of-korea-and-china
#15
REVIEW
Kentaro Yoshii, Joon Young Song, Seong-Beom Park, Junfeng Yang, Heinz-Josef Schmitt
Tick-borne encephalitis virus (TBEV) causes mild or moderate febrile illness in humans that may progress to encephalitis, leading to severe long-term complications and sometimes death. TBEV is prevalent in the Eurasian continent and has been isolated in China, Japan and Republic of Korea (ROK). The TBEV isolates from Japan are of the Far-Eastern subtype; in ROK, the isolates are of the Western subtype; and all TBEV isolates in China are of the Far-Eastern subtype, except one strain that was identified most recently as the Siberian subtype...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28869941/identifying-attenuating-mutations-tools-for-a-new-vaccine-design-against-flaviviruses
#16
Cécile Khou, Nathalie Pardigon
Emerging Flaviviruses pose an increasing threat to global human health. To date, human vaccines against yellow fever virus (YFV), Japanese encephalitis virus (JEV), dengue virus (DV), and tick-borne encephalitis virus (TBEV) exist. However, there is no human vaccine against other Flaviviruses such as Zika virus (ZIKV) and West Nile virus (WNV). In order to restrict their spread and to protect populations against the diseases they induce, vaccines against these emerging viruses must be designed. Obtaining new live attenuated Flavivirus vaccines using molecular biology methods is now possible...
2017: Intervirology
https://www.readbyqxmd.com/read/28830948/flavivirus-infection-of-ixodes-scapularis-black-legged-tick-ex-vivo-organotypic-cultures-and-applications-for-disease-control
#17
Jeffrey M Grabowski, Konstantin A Tsetsarkin, Dan Long, Dana P Scott, Rebecca Rosenke, Tom G Schwan, Luwanika Mlera, Danielle K Offerdahl, Alexander G Pletnev, Marshall E Bloom
Ixodes scapularis ticks transmit many infectious agents that cause disease, including tick-borne flaviviruses (TBFVs). TBFV infections cause thousands of human encephalitis cases worldwide annually. In the United States, human TBFV infections with Powassan virus (POWV) are increasing and have a fatality rate of 10 to 30%. Additionally, Langat virus (LGTV) is a TBFV of low neurovirulence and is used as a model TBFV. TBFV replication and dissemination within I. scapularis organs are poorly characterized, and a deeper understanding of virus biology in this vector may inform effective countermeasures to reduce TBFV transmission...
August 22, 2017: MBio
https://www.readbyqxmd.com/read/28827760/protein-structure-shapes-immunodominance-in-the-cd4-t-cell-response-to-yellow-fever-vaccination
#18
Maximilian Koblischke, Maria S Mackroth, Julia Schwaiger, Ingrid Fae, Gottfried Fischer, Karin Stiasny, Franz X Heinz, Judith H Aberle
The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles internalized and processed by E-specific B cells. The CD4 T helper cell response is restricted to few immunodominant epitopes, but the mechanisms of their selection are largely unknown. Here, we report that CD4 T cell responses elicited by the YF-17D vaccine are focused to hotspots of two helices of the viral capsid protein and to exposed strands and loops of E...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770638/systematic-literature-review-comparing-rapid-3-dose-administration-of-the-gsk-tick-borne-encephalitis-vaccine-with-other-primary-immunization-schedules
#19
Ilaria Galgani, Eveline M Bunge, Lisa Hendriks, Christopher Schludermann, Cinzia Marano, Laurence De Moerlooze
Tick-borne encephalitis (TBE), which is endemic across large regions of Europe and Asia, is most effectively prevented through vaccination. Three-dose primary TBE vaccination schedules are either rapid (0,7,21-days) or conventional (0,28-84-days, 9-12-months). The second dose can also be administered at 14 days for faster priming and sero-protection). Areas covered: We used a three-step selection process to identify 21 publications comparing the immunogenicity and/or safety of different schedules. Expert commentary: Priming with two or three TBE vaccine doses was highly immunogenic...
September 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28762591/ean-consensus-review-on-prevention-diagnosis-and-management-of-tick-borne-encephalitis
#20
REVIEW
P Taba, E Schmutzhard, P Forsberg, I Lutsar, U Ljøstad, Å Mygland, I Levchenko, F Strle, I Steiner
BACKGROUND AND PURPOSE: Tick-borne encephalitis (TBE) is an infection of the central nervous system (CNS) caused by tick-borne encephalitis virus (TBEV) and transmitted by ticks, with a variety of clinical manifestations. The incidence of TBE in Europe is increasing due to an extended season of the infection and the enlargement of endemic areas. Our objectives are to provide recommendations on the prevention, diagnosis and management of TBE, based on evidence or consensus decisions. METHODS: For systematic evaluation, the literature was searched from 1970 to 2015 (including early online publications of 2016), and recommendations were based on evidence or consensus decisions of the Task Force when evidence-based data were not available...
October 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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