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Japanese encephalitis vaccine

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https://www.readbyqxmd.com/read/29900012/current-status-of-zika-vaccine-development-zika-vaccines-advance-into-clinical-evaluation
#1
REVIEW
Alan D T Barrett
Zika virus (ZIKV), a mosquito-borne flavivirus, was first identified in the 1940s in Uganda in Africa and emerged in the Americas in Brazil in May 2015. In the 30 months since ZIKV emerged as a major public health problem, spectacular progress has been made with vaccine development cumulating with the publication of three reports of phase 1 clinical trials in the 4th quarter of 2017. Clinical trials involving candidate DNA and purified inactivated virus vaccines showed all were safe and well-tolerated in the small number of volunteers and all induced neutralizing antibodies, although these varied by vaccine candidate and dosing regimen...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29891351/adverse-events-following-vaccination-with-an-inactivated-vero-cell-culture-derived-japanese-encephalitis-vaccine-in-the-united-states-2012-2016
#2
William L Walker, Susan L Hills, Elaine R Miller, Marc Fischer, Ingrid B Rabe
BACKGROUND: In March 2009, the U.S. Food and Drug Administration licensed an inactivated Vero cell culture-derived Japanese encephalitis vaccine (JE-VC [IXIARO®]) for use in persons aged ≥17 years. In 2013, licensure was extended to include children aged ≥2 months. A previous analysis reviewed adverse events reported to the U.S. Vaccine Adverse Event Reporting System (VAERS) from May 2009 through April 2012. METHODS: We reviewed adverse events reported to VAERS following JE-VC administered from May 1, 2012 through April 30, 2016...
June 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29877787/development-of-a-japanese-encephalitis-virus-genotype-v-virus-like-particle-vaccine-in-silkworms
#3
Kuniaki Nerome, Ryoji Yamaguchi, Naoyuki Fuke, Uda Zahli Izzati, Kenichi Maegawa, Shigeo Sugita, Kazunori Kawasaki, Kazumichi Kuroda, Reiko Nerome
To counter the spread of multiple Japanese encephalitis virus (JEV) variants harboured in alternative host species and highly neurotoxic variants with new antigenicity, such as genotype V (Muar), methods for developing more effective and low-cost vaccines against a variety of epidemic JEV strains are required. Here, we successfully synthesized large amounts of a Muar virus-like particle (MVLP) vaccine for JEV in silkworm pupae by using a Bombyx mori nuclear polyhedrosis virus recombinant consisting of JEV codon-optimized envelope (E) DNA...
June 7, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29845525/the-molecular-specificity-of-the-human-antibody-response-to-dengue-virus-infections
#4
Emily N Gallichotte, Ralph S Baric, Aravinda M de Silva
Dengue viruses (DENV) are mosquito-borne positive sense RNA viruses in the family Flaviviridae. The four serotypes of DENV (DENV1, DENV2, DENV3, DENV4) are widely distributed and it is estimated over a third of the world's population is at risk of infection [4]. While the majority of infections are asymptomatic, DENV infection can cause a spectrum of disease, from mild flu-like symptoms, to the more severe DENV hemorrhagic fever and shock syndrome [24]. Over the past 20 years, there have been intense efforts to develop a tetravalent live-attenuated DENV vaccine [36]...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29789537/detection-of-japanese-encephalitis-virus-rna-in-human-throat-samples-in-laos-a-pilot-study
#5
Tehmina Bharucha, Onanong Sengvilaipaseuth, Malee Seephonelee, Malavanh Vongsouvath, Manivanh Vongsouvath, Sayaphet Rattanavong, Géraldine Piorkowski, Marc Lecuit, Christopher Gorman, Jean-David Pommier, Paul N Newton, Xavier de Lamballerie, Audrey Dubot-Pérès
Japanese encephalitis virus (JEV) is the most commonly identified cause of acute encephalitis syndrome (AES) in Asia. The WHO recommended test is anti-JEV IgM-antibody-capture-enzyme-linked-immunosorbent-assay (JEV MAC-ELISA). However, data suggest this has low positive predictive value, with false positives related to other Flavivirus infections and vaccination. JEV RT-PCR in cerebrospinal fluid (CSF) and/or serum is highly specific, but is rarely positive; 0-25% of patients that fulfil the WHO definition of JE (clinical Acute Encephalitis Syndrome (AES) and JEV MAC-ELISA positive)...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784468/vaccines-and-the-risk-of-acute-disseminated-encephalomyelitis
#6
Yong Chen, Fubao Ma, Yuanling Xu, Xuhua Chu, Jinlin Zhang
BACKGROUND: It is important to examine the risk of Acute disseminated encephalomyelitis (ADEM) after vaccination. METHODS: We conducted a nested case-control study between January 2011 and December 2015. Four controls per case were matched for age, gender, address. An independent expert committee validated the diagnoses of cases and controls. Data on vaccinations were obtained from computerized vaccination records. The analyses were conducted with the use of conditional logistic regression...
May 18, 2018: Vaccine
https://www.readbyqxmd.com/read/29748549/genotype-i-of-japanese-encephalitis-virus-virus-like-particles-elicit-sterilizing-immunity-against-genotype-i-and-iii-viral-challenge-in-swine
#7
Yi-Chin Fan, Jo-Mei Chen, Jen-Wei Lin, Yi-Ying Chen, Guan-Hong Wu, Kuan-Hsuan Su, Ming-Tang Chiou, Shang-Rung Wu, Ji-Hang Yin, Jiunn-Wang Liao, Gwong-Jen J Chang, Shyan-Song Chiou
Swine are a critical amplifying host involved in human Japanese encephalitis (JE) outbreaks. Cross-genotypic immunogenicity and sterile protection are important for the current genotype III (GIII) virus-derived vaccines in swine, especially now that emerging genotype I (GI) JE virus (JEV) has replaced GIII virus as the dominant strain. Herein, we aimed to develop a system to generate GI JEV virus-like particles (VLPs) and evaluate the immunogenicity and protection of the GI vaccine candidate in mice and specific pathogen-free swine...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741721/update-from-the-advisory-committee-on-immunization-practices
#8
Sean T O'Leary, David W Kimberlin, Yvonne A Maldonado
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. The ACIP met on October 25 and 26, 2017, to discuss herpes zoster vaccine, the child/adolescent and adult vaccination schedules, Japanese encephalitis (JE) epidemiology and vaccines, pneumococcal vaccines, anthrax vaccines and disaster preparedness, hepatitis A outbreaks, influenza surveillance and vaccination coverage, vaccine safety, and considerations for a potential third dose of measles-mumps-rubella (MMR) vaccine to combat ongoing mumps outbreaks...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29741521/an-outbreak-of-japanese-encephalitis-in-a-non-endemic-region-of-north-east-india
#9
H McNaughton, A Singh, S A Khan
Background There are few comprehensive reports of epidemic Japanese encephalitis in a previously unaffected region. We report our experience of a first-ever outbreak of it in Sonitpur District, Assam, India, with 45 laboratorycon confirmed cases at a single hospital. Method Between 2 July and 11 August 2008, patients meeting the WHO definition of acute encephalitis syndrome were assessed in a single hospital and had tests including blood and cerebrospinal fluid for Japanese encephalitis antibody titres. Results Ninety-six cases meeting the definition of acute encephalitis syndrome were identified with 45 cases of Japanese encephalitis confirmed by cerebrospinal fluid or blood results...
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29740970/japanese-encephalitis-circulation-pattern-in-swine-of-northern-vietnam-and-consequences-for-swine-s-vaccination-recommendations
#10
A-S Ruget, C Beck, A Gabassi, K Trevennec, S Lecollinet, V Chevalier, J Cappelle
Japanese encephalitis (JE) is the largest worldwide cause of infectious encephalitis in humans and is caused by a mosquito-borne flavivirus. JE transmission cycle involves Culex mosquitoes, pigs and aquatic birds as principal vertebrate amplifying hosts. JE infection is responsible for reproductive disorder in pigs when occurring after sexual maturity. In tropical areas, JE is endemic and the majority of pigs get infected before the age of 6 months. However, in subtropical areas, pigs may be infected after sexual maturity and thus experience clinical signs, inducing economic loss...
May 8, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29703709/effectiveness-of-japanese-encephalitis-sa-14-14-2-live-attenuated-vaccine-among-indian-children-retrospective-1-4-matched-case-control-study
#11
Babasaheb V Tandale, Siraj A Khan, Komal P Kushwaha, Helina Rahman, Milind M Gore
OBJECTIVES: We estimate the effectiveness of Japanese encephalitis (JE) SA 14-14-2 live-attenuated vaccination single dose campaign among children aged 1-15 years in India during 2006-07. METHODS: Acute encephalitis syndrome (AES) cases hospitalized following vaccination campaigns during the years 2006-08 were investigated retrospectively. The laboratory-confirmed JE cases were detected from the surveillance laboratories based on anti-JE IgM antibody by ELISA or viral RNA detection by RT-PCR in sera or cerebrospinal fluid...
April 24, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29688492/adverse-events-in-vaccinations-for-travelers-a-1-year-prospective-survey-in-a-travel-clinic-in-germany
#12
Günther Slesak, Ralf Fleck, Helmut Scherbaum, Gunnar Blumenstock, Johannes Schäfer
Background: The study goal was to assess and compare adverse events (AE) of current vaccinations for travelers under 'real-life conditions'. Methods: A prospective observational online questionnaire study was performed from May 2015 till April 2016 in a travel clinic in Germany. Online questionnaire links were sent 1 week after the first vaccination date. Severity was rated on a scale from 1 to 5 (minor to very severe AE). Results: Of 1357 vaccinees 781 (57...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29673445/the-relationship-between-japanese-encephalitis-and-environmental-factors-in-china-explored-using-national-surveillance-data
#13
Xiao Xia Huang, Lei Yan, Xiao Yan Gao, Yu Huan Ren, Shi Hong Fu, Yu Xi Cao, Ying He, Wen Wen Lei, Guo Dong Liang, Shi Wen Wang, Huan Yu Wang
Japanese encephalitis (JE) is a serious public health issue. This study was undertaken to better understand the relationship between JE distribution and environmental factors in China. JE data from 2005 to 2010 were retrieved from National Notifiable Disease Report System. ArcGIS, remote sensing techniques, and R software was used to exhibit and explore the relationship between JE distribution and environmental factors. Our results indicated that JE cases were mostly concentrated in warm-temperate, semitropical and tropical zones with annual precipitation > 400 mm; Broad-leaved evergreen forest, shrubs, paddy field, irrigated land, dryland, evergreen coniferous forest, and shrubland were risk factors for JE occurrence, and the former five were risk factors for counties with high JE incidence...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29665373/human-monoclonal-antibodies-against-west-nile-virus-from-japanese-encephalitis-vaccinated-volunteers
#14
Tatsuhiko Ozawa, Hideyuki Masaki, Tomohiko Takasaki, Ikuko Aoyama, Takahiro Yumisashi, Atsushi Yamanaka, Eiji Konishi, Yoh Ohnuki, Atsushi Muraguchi, Hiroyuki Kishi
West Nile virus (WNV) is a positive-sense single-stranded RNA flavivirus belonging to the Japanese encephalitis virus (JEV) serocomplex of the Flaviviridae family and causes mosquito-borne infections. Although most human infection cases are asymptomatic, approximately one in 150 infected individuals develops meningoencephalitis, with a mortality rate of 4-14%. While the development of human neutralizing antibody therapeutics against WNV is strongly anticipated, WNV is difficult to study in conventional laboratories due to its high safety level requirement...
June 2018: Antiviral Research
https://www.readbyqxmd.com/read/29605839/genomic-changes-in-an-attenuated-genotype-i-japanese-encephalitis-virus-and-comparison-with-virulent-parental-strain
#15
Yuyong Zhou, Rui Wu, Yao Feng, Qin Zhao, Xintian Wen, Xiaobo Huang, Yiping Wen, Qigui Yan, Yong Huang, Xiaoping Ma, Xinfeng Han, Sanjie Cao
Genotype I Japanese encephalitis virus (JEV) strain SCYA201201 was previously isolated from brain tissues of aborted piglets. In this study, we obtained an attenuated SCYA201201-0901 strain by serial passage of strain SCYA201201-1 in Syrian baby hamster kidney cells, combined with multiple plaque purifications and selection for virulence in mice. We investigated the genetic changes associated with attenuation by comparing the entire genomes of SCYA201201-0901 and SCYA201201-1. Sequence comparisons identified 14 common amino acid substitutions in the coding region, with two nucleotide point mutations in the 5'-untranslated region (UTR) and another three in the 3'-UTR, which differed between the attenuated and virulent strains...
June 2018: Virus Genes
https://www.readbyqxmd.com/read/29580643/japanese-encephalitis-virus-yellow-fever-virus-chimera-is-safe-and-confers-full-protection-against-yellow-fever-virus-in-intracerebrally-challenged-mice
#16
Huiqiang Yang, Huan Yang, Zhushi Li, Lina Liu, Wei Wang, Ting He, Fengming Fan, Yan Sun, Jie Liu, Yuhua Li, Xianwu Zeng
Yellow fever (YF) is an acute viral haemorrhagic disease caused by the yellow fever virus (YFV), which remains a potential threat to public health. The live-attenuated YF vaccine (17D strain) is a safe and highly effective measure against YF. However, increasing adverse events have been associated with YF vaccinations in recent years; thus, safer, alternative vaccines are needed. In this study, using the Japanese encephalitis live vaccine strain SA14-14-2 as a backbone, a novel chimeric virus was constructed by replacing the pre-membrane (prM) and envelope (E) genes with their YFV 17D counterparts...
April 25, 2018: Vaccine
https://www.readbyqxmd.com/read/29567514/development-of-an-anti-dengue-ns1-igg-elisa-to-evaluate-exposure-to-dengue-virus
#17
Eduardo J M Nascimento, James K George, Melissa Velasco, Matthew I Bonaparte, Lingyi Zheng, Carlos A DiazGranados, Ernesto T A Marques, James W Huleatt
Dengue virus infection elicits immune responses to multiple viral antigens including antibodies to dengue non-structural protein 1 (NS1) which are rapidly induced and detected within days of infection. The recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV; Sanofi Pasteur) uses the yellow fever vaccine virus as a back-bone but expresses dengue virus pre-membrane and envelop proteins. Since CYD-TDV does not express dengue NS1, we evaluated the utility of dengue NS1-specific IgG antibodies as biomarkers of dengue exposure in CYD-TDV recipients and controls...
July 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29549036/safety-and-immunogenicity-of-an-inactivated-vero-cell_derived-japanese-encephalitis-vaccine-ixiaro-%C3%A2-jespect-%C3%A2-in-a-pediatric-population-in-je-non-endemic-countries-an-uncontrolled-open-label-phase-3-study
#18
Tomas Jelinek, Michael A Cromer, Jakob P Cramer, Deborah J Mills, Kenneth Lessans, Anthony W Gherardin, Elizabeth D Barnett, Stefan H F Hagmann, Helena H Askling, Sigrid Kiermayr, Vera Kadlecek, Susanne Eder-Lingelbach, Christian Taucher, Katrin L Dubischar
BACKGROUND: Young travelers to South-East Asia may be at risk for Japanese encephalitis (JE). METHODS: IXIARO® (0.25 ml or 0.5 ml, depending on age) were administrated to 100 travelers aged ≥ 2 months to < 18 years. Solicited AEs were collected for 7 days after each injection, unsolicited adverse events (AEs) for a total of 7 months. JE neutralizing antibodies were assessed in 64 subjects. RESULTS: The most common solicited local AEs were redness (3/12 subjects), induration and tenderness (both 1/12) with 0...
March 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29511073/diagnosis-of-zika-virus-infection-by-peptide-array-and-enzyme-linked-immunosorbent-assay
#19
Nischay Mishra, Adrian Caciula, Adam Price, Riddhi Thakkar, James Ng, Lokendra V Chauhan, Komal Jain, Xiaoyu Che, Diego A Espinosa, Magelda Montoya Cruz, Angel Balmaseda, Eric H Sullivan, Jigar J Patel, Richard G Jarman, Jennifer L Rakeman, Christina T Egan, Chantal B E M Reusken, Marion P G Koopmans, Eva Harris, Rafal Tokarz, Thomas Briese, W Ian Lipkin
Zika virus (ZIKV) is implicated in fetal stillbirth, microcephaly, intracranial calcifications, and ocular anomalies following vertical transmission from infected mothers. In adults, infection may trigger autoimmune inflammatory polyneuropathy. Transmission most commonly follows the bite of infected Aedes mosquitoes but may also occur through sexual intercourse or receipt of blood products. Definitive diagnosis through detection of viral RNA is possible in serum or plasma within 10 days of disease onset, in whole blood within 3 weeks of onset, and in semen for up to 3 months...
March 6, 2018: MBio
https://www.readbyqxmd.com/read/29487230/mouse-and-human-monoclonal-antibodies-protect-against-infection-by-multiple-genotypes-of-japanese-encephalitis-virus
#20
Estefania Fernandez, Nurgun Kose, Melissa A Edeling, Jagat Adhikari, Gopal Sapparapu, Susana M Lazarte, Christopher A Nelson, Jennifer Govero, Michael L Gross, Daved H Fremont, James E Crowe, Michael S Diamond
Japanese encephalitis virus (JEV) remains a leading cause of viral encephalitis worldwide. Although JEV-specific antibodies have been described, an assessment of their ability to neutralize multiple genotypes of JEV has been limited. Here, we describe the development of a panel of mouse and human neutralizing monoclonal antibodies (MAbs) that inhibit infection in cell culture of four different JEV genotypes tested. Mechanism-of-action studies showed that many of these MAbs inhibited infection at a postattachment step, including blockade of virus fusion...
February 27, 2018: MBio
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