keyword
MENU ▼
Read by QxMD icon Read
search

Japanese encephalitis vaccine

keyword
https://www.readbyqxmd.com/read/27903416/post-licensure-phase-iv-safety-study-of-a-live-attenuated-japanese-encephalitis-recombinant-vaccine-in-children-in-thailand
#1
Tawee Chotpitayasunondh, Pornpimol Pruekprasert, Thanyawee Puthanakit, Chitsanu Pancharoen, Auchara Tangsathapornpong, Peninnah Oberdorfer, Pope Kosalaraksa, Olarn Prommalikit, Suwimon Tangkittithaworn, Phirangkul Kerdpanich, Chonnamet Techasaensiri, Joanna Korejwo, Sunate Chuenkitmongkol, Guy Houillon
BACKGROUND: Japanese encephalitis is a mosquito-borne viral disease endemic in most countries in Asia. A recombinant live, attenuated Japanese encephalitis virus vaccine, JE-CV, is licensed in 14 countries, including Thailand, for the prevention of Japanese encephalitis in adults and children. METHODS: This was a prospective, phase IV, open-label, multicentre, safety study of JE-CV conducted from November 2013 to April 2015, to evaluate rare serious adverse events (AEs)...
November 28, 2016: Vaccine
https://www.readbyqxmd.com/read/27846060/immunogenicity-of-a-live-attenuated-chimeric-japanese-encephalitis-vaccine-as-a-booster-dose-after-primary-vaccination-with-live-attenuated-sa14-14-2-vaccine-a-phase-iv-study-in-thai-children
#2
Sirintip Sricharoenchai, Keswadee Lapphra, Sunate Chuenkitmongkol, Wanatpreeya Phongsamart, Alain Bouckenooghe, Orasri Wittawatmongkol, Supattra Rungmaitree, Kulkanya Chokephaibulkit
This single-group study investigated the immunogenicity and safety of a booster dose of the recently licensed live attenuated chimeric Japanese encephalitis vaccine in 50 healthy children (1-5 years old) who were primed with the live attenuated SA14-14-2 vaccine. A strong anamnestic response was induced 28 days post-booster: GMT, 9,144 (95% CI 7,365-11,353); and seroprotection rate, 49/49 (100%) children.
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27821699/epidemiological-features-of-japanese-encephalitis-in-taiwan-from-2000-to-2014
#3
Yu-Kang Chang, Hsiao-Ling Chang, Ho-Sheng Wu, Kow-Tong Chen
The incidence of Japanese encephalitis (JE) decreased sharply after the national vaccination program was implemented in Taiwan in 1968. However, cases of JE still occur. The purpose of this study was to assess the epidemiology and vaccination policy for JE in Taiwan. We analyzed the data on JE cases reported to the Taiwan Centers for Disease Control (Taiwan CDC) between 2000 and 2014. During the 15-year study period, a total of 4,474 cases were reported to the Taiwan CDC. Of these, 379 (8.5%) were classified as confirmed cases, and 4,095 (91...
November 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27815383/persistence-of-wild-type-japanese-encephalitis-virus-strains-cross-neutralization-five-years-following-je-cv-immunization
#4
Emmanuel Feroldi, Mark Boaz, Sutee Yoksan, Kulkanya Chokephaibulkit, Usa Thisyakorn, Chitsanu Pancharoen, Céline Monfredo, Alain Bouckenooghe
BACKGROUND:  The live-attenuated Japanese encephalitis (JE) vaccine (JE-CV; IMOJEV(®)) induces a protective response in children. A shift in circulating JE virus strains suggests that a genotype shift phenomenon may occur throughout South-East Asia. We assessed the neutralization of wild-type (WT) JE virus isolates at distal time points post-vaccination. METHODS:  We analysed serum samples from a subset of 47 children who had received a JE-CV booster after an inactivated JE vaccine primary immunization...
November 3, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27799502/refusal-of-recommended-travel-related-vaccines-among-u-s-international-travellers-in-global-travepinet
#5
Sara M Lammert, Sowmya R Rao, Emily S Jentes, Jessica K Fairley, Stefanie Erskine, Allison T Walker, Stefan H Hagmann, Mark J Sotir, Edward T Ryan, Regina C LaRocque
BACKGROUND: International travellers are at risk of travel-related, vaccine-preventable diseases. More data are needed on the proportion of travellers who refuse vaccines during a pre-travel health consultation and their reasons for refusing vaccines. METHODS: We analyzed data on travellers seen for a pre-travel health consultation from July 2012 through June 2014 in the Global TravEpiNet (GTEN) consortium. Providers were required to indicate one of three reasons for a traveller refusing a recommended vaccine: (1) cost concerns, (2) safety concerns or (3) not concerned with the illness...
July 2016: Journal of Travel Medicine
https://www.readbyqxmd.com/read/27773472/immunogenicity-of-live-attenuated-japanese-encephalitis-sa-14-14-2-vaccine-among-sri-lankan-children-with-previous-receipt-of-inactivated-je-vaccine
#6
Pushpa Ranjan Wijesinghe, M R Nihal Abeysinghe, Sutee Yoksan, Yafu Yao, Benli Zhou, Lei Zhang, Jessica A Fleming, Anthony A Marfin, John C Victor
BACKGROUND: The performance of live attenuated Japanese Encephalitis SA 14-14-2 vaccine (CD-JEV) among children previously given inactivated mouse brain-derived JE vaccine (IMBV) is unknown. We evaluated the safety and immunogenicity of CD-JEV administered to 2- and 5-year-old children in Sri Lanka. METHODS: In this open-label, single arm trial in the Colombo District of Sri Lanka, generally healthy children 2 and 5years of age who had previously received two and three doses of IMBV, respectively, were administered one dose of CD-JEV subcutaneously...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27756212/japanese-encephalitis-vaccine-facilitated-dengue-virus-infection-enhancement-antibody-in-adults
#7
Yuka Saito, Meng Ling Moi, Nozomi Takeshita, Chang-Kweng Lim, Hajime Shiba, Kuniaki Hosono, Masayuki Saijo, Ichiro Kurane, Tomohiko Takasaki
BACKGROUND: Dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the genus Flavivirus, and infection with a virus within this genus induces antibodies that are cross-reactive to other flaviviruses. Particularly in DENV infection, antibodies to DENV possess two competing activities: neutralizing activity and infection-enhancing activity. These antibody activities are considered central in modulating clinical outcomes of DENV infection. Here, we determined the neutralizing and infection-enhancing activity of DENV cross-reactive antibodies in adults before and after JE vaccination...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27743649/electroporation-enhances-protective-immune-response-of-a-dna-vaccine-against-japanese-encephalitis-in-mice-and-pigs
#8
Ziyang Sheng, Na Gao, Xiaoyun Cui, Dongying Fan, Hui Chen, Na Wu, Jianchun Wei, Jing An
Japanese encephalitis virus (JEV) is a pathogenic cause of Japanese Encephalitis (JE), which is a zoonotic disease transmitted by mosquitoes and amplified by pigs. Infection of JEV may lead to severe neurological sequelae, even death in humans and reproductive disorders in pigs. Vaccination is the only way to control JEV infection in humans. For pigs play important role in the JEV transmission cycle, developing a new veterinary vaccine is considered as a useful strategy for cutting off the transmission route of JEV...
October 12, 2016: Vaccine
https://www.readbyqxmd.com/read/27727408/safety-of-live-attenuated-japanese-encephalitis-vaccine-given-at-the-age-of-9-months-in-national-immunisation-programme-of-sri-lanka
#9
K Sanchayan, R Fernandopulle, A Amarasinghe, S N Thiyahiny, S Sri Ranganathan
OBJECTIVES: This study was designed to describe the safety profile of the single dose live attenuated Japanese encephalitis vaccine (LJEV) SA-14-14-2 given at the age of 9 months in the National Immunisation programme of Sri Lanka. METHODS: cohort event monitoring (CEM) was conducted in the Jaffna district during November 2012 to January 2015. A representative sample of 3041 infants who received the LJEV at the age of 9 months was followed up actively over telephone interviews on days 1, 3, 14, 30 and 45 for adverse events (AE)...
2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/27715427/tick-borne-encephalitis-what-travellers-should-know-when-visiting-an-endemic-country
#10
Aleš Chrdle, Vaclav Chmelik, Daniel Ruzek
Tick-borne encephalitis (TBE) is an acute febrile illness with neurological manifestations that is prevalent in forested areas of moderate climate in Europe and Asia. TBE virus is transmitted by ticks and rarely by unpasteurized milk and dairy products. The disease burden is attributed mainly to resulting long-term disability, especially in individuals over 50 years of age. Currently, there is no causative treatment, but a very effective vaccination is available with a good safety profile. The vaccination requires three basic doses to be fully effective and regular boosters afterwards...
August 15, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27702638/application-of-various-control-strategies-to-japanese-encephalitic-a-mathematical-study-with-human-pig-and-mosquito
#11
A De, K Maity, Soovoojeet Jana, M Maiti
Japanese encephalitis (JE) is a public health problem that threats the entire world today. Japanese Encephalitis virus (JEV) mostly became a threat due to the significant number of increase of susceptible mosquito vectors and vertebrate hosts in Asia by which around 70,000 cases and 10,000 deaths per year took place in children below 15 years of age. In this paper, a mathematical model of JE due to JEV from the vector source (infected mosquito) and two vertebrate hosts (infected human and infected pig) is formulated...
December 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27692881/decreased-vaccine-antibody-titers-following-exposure-to-multiple-metals-and-metalloids-in-e-waste-exposed-preschool-children
#12
Xinjiang Lin, Xijin Xu, Xiang Zeng, Long Xu, Zhijun Zeng, Xia Huo
We explored acquired immunity resulting from vaccination in 3 to 7-year-old children, chronically exposed to multiple heavy metals and metalloids, in an e-waste recycling area (Guiyu, China). Child blood levels of ten heavy metals and metalloids, including lead (Pb), arsenic (As), mercury (Hg), chromium (Cr), cadmium (Cd), manganese (Mn), nickel (Ni), copper (Cu), zinc (Zn) and selenium (Se), and seven vaccine antibodies (diphtheria, pertussis, tetanus, hepatitis B, Japanese encephalitis, polio, measles) were measured...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27686833/long-term-follow-up-of-japanese-encephalitis-chimeric-virus-vaccine-immune-responses-in-children
#13
Kulkanya Chokephaibulkit, Chukiat Sirivichayakul, Usa Thisyakorn, Chitsanu Pancharoen, Mark Boaz, Alain Bouckenooghe, Emmanuel Feroldi
BACKGROUND: A single dose of live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) was shown to be immunogenic and well tolerated when given either as a booster to formalin-inactivated Japanese encephalitis (JE)-vaccine (mouse brain-derived vaccine [MBDV])-primed 2-5-year-olds, or as a primary vaccination to JE-vaccine-naïve 12-24-month-old toddlers in Thailand. A 5-year follow-up assessment of immune response persistence over time was conducted. METHODS: Four additional visits (at 2, 3, 4, and 5years) for immunologic assessments were added to the original 12-month open-label crossover study, in which 100 healthy children aged 2-5years with a history of two-dose primary vaccination with MBDV (according to the Thai Expanded Program for Immunization schedule), and 200 healthy JE-vaccine-naïve 12-24-month-old toddlers, were randomized 1:1 to receive JE-CV, containing ⩾4 log10 plaque forming units, 1month before or after hepatitis A control vaccine...
September 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27679979/structure-based-discovery-of-two-antiviral-inhibitors-targeting-the-ns3-helicase-of-japanese-encephalitis-virus
#14
Jin'e Fang, Huan Li, Dexin Kong, Shengbo Cao, Guiqing Peng, Rui Zhou, Huanchun Chen, Yunfeng Song
Japanese encephalitis virus (JEV) is a flavivirus that threatens more than half of the world's population. Vaccination can prevent the disease, but no specific antiviral drug is yet available for clinical therapy, and the death rate caused by JEV can reach as high as 60%. The C-terminus of non-structural protein 3 (NS3) of flavivirus encodes helicase and has been identified as a potential drug target. In this study, high throughput molecular docking was employed to identify candidate JEV NS3 helicase inhibitors in a commercial library containing 250,000 compounds...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27642668/cross-reactive-antibodies-enhance-live-attenuated-virus-infection-for-increased-immunogenicity
#15
Kuan Rong Chan, Xiaohui Wang, Wilfried A A Saron, Esther Shuyi Gan, Hwee Cheng Tan, Darren Z L Mok, Summer Li-Xin Zhang, Yie Hou Lee, Cui Liang, Limin Wijaya, Sujoy Ghosh, Yin Bun Cheung, Steven R Tannenbaum, Soman N Abraham, Ashley L St John, Jenny G H Low, Eng Eong Ooi
Vaccination has achieved remarkable successes in the control of childhood viral diseases. To control emerging infections, however, vaccines will need to be delivered to older individuals who, unlike infants, probably have had prior infection or vaccination with related viruses and thus have cross-reactive antibodies against the vaccines. Whether and how these cross-reactive antibodies impact live attenuated vaccination efficacy is unclear. Using an open-label randomized trial design, we show that subjects with a specific range of cross-reactive antibody titres from a prior inactivated Japanese encephalitis vaccination enhanced yellow fever (YF) immunogenicity upon YF vaccination...
September 19, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27633257/a-serological-protein-microarray-for-detection-of-multiple-cross-reactive-flavivirus-infections-in-horses-for-veterinary-and-public-health-surveillance
#16
N B Cleton, K van Maanen, S A Bergervoet, N Bon, C Beck, G-J Godeke, S Lecollinet, R Bowen, D Lelli, N Nowotny, M P G Koopmans, C B E M Reusken
The genus Flavivirus in the family Flaviviridae includes some of the most important examples of emerging zoonotic arboviruses that are rapidly spreading across the globe. Japanese encephalitis virus (JEV), West Nile virus (WNV), St. Louis encephalitis virus (SLEV) and Usutu virus (USUV) are mosquito-borne members of the JEV serological group. Although most infections in humans are asymptomatic or present with mild flu-like symptoms, clinical manifestations of JEV, WNV, SLEV, USUV and tick-borne encephalitis virus (TBEV) can include severe neurological disease and death...
September 15, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27628323/immunogenicity-of-a-japanese-encephalitis-chimeric-virus-vaccine-as-a-booster-dose-after-primary-vaccination-with-sa14-14-2-vaccine-in-thai-children
#17
Pakpoom Janewongwirot, Thanyawee Puthanakit, Suvaporn Anugulruengkitt, Watsamon Jantarabenjakul, Chayapa Phasomsap, Sompong Chumket, Sutee Yoksan, Chitsanu Pancharoen
BACKGROUND: Japanese Encephalitis chimeric virus vaccine (JE-CV) and SA14-14-2 vaccine are live-attenuated JE vaccines produced from the same virus strain. Data on interchangeability is limited. OBJECTIVES: To evaluate the immunogenicity and safety of JE-CV booster after primary vaccination with SA14-14-2 vaccine. METHODS: This study was an open-label clinical trial in Thai children who had received a primary SA14-14-2 vaccination at 12-24monthsbefore enrollment (ClinicalTrials...
October 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27592194/association-between-timely-initiation-of-hepatitis-b-vaccine-and-completion-of-the-hepatitis-b-vaccine-and-national-immunization-program-vaccine-series
#18
Jiang-Nan Wu, Da-Jin Li, Yong Zhou
BACKGROUND: Little is known about the association between the initiation of hepatitis B vaccine (HB vaccine) at birth and completion of the HB vaccine and the national immunization program vaccine (NIPV) series in Fujian, China. METHODS: A provincial survey, including children in the community and newborns in hospital, was conducted to evaluate coverage with a timely first dose of HB vaccine and the completion of three doses of HB vaccine and the NIPV series in 2013...
August 31, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27580555/knowledge-obtained-from-an-elderly-case-of-japanese-encephalitis
#19
Kyoko Itoh, Kazuhide Iwamoto, Yu Satoh, Tomoaki Fujita, Kenta Takahashi, Harutaka Katano, Hideki Hasegawa, Tomohiko Takasaki, So Tando, Shinji Fushiki
The nationwide introduction of a Japanese encephalitis (JE) vaccine has contributed to a reduction in the annual infection rate of JE in Japan. However, the current neutralizing antibody prevalence ratio in Japan is approximately 20% in children 3-4 years of age and in people in their forties and fifties. We herein report a man with JE who was definitively diagnosed by multi-virus real-time polymerase chain reaction employing biopsied brain tissue and serological examinations. JE should be kept in mind when a patient has severe encephalitis of unknown etiology...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27573631/dengue-virus-seroconversion-in-travelers-to-dengue-endemic-areas
#20
Rosemary M Olivero, Davidson H Hamer, William B MacLeod, Christine M Benoit, Carolina Sanchez-Vegas, Emily S Jentes, Lin H Chen, Mary E Wilson, Nina Marano, Emad A Yanni, Winnie W Ooi, Adolf W Karchmer, Laura Kogelman, Elizabeth D Barnett
We conducted a prospective study to measure dengue virus (DENV) antibody seroconversion in travelers to dengue-endemic areas. Travelers seen in the Boston Area Travel Medicine Network planning to visit dengue-endemic countries for ≥ 2 weeks were enrolled from 2009 to 2010. Pre- and post-travel blood samples and questionnaires were collected. Post-travel sera were tested for anti-DENV IgG by indirect IgG enzyme-linked immunosorbent assay (ELISA) and anti-DENV IgM by capture IgM ELISA. Participants with positive post-travel anti-DENV IgG or IgM were tested for pre-travel anti-DENV IgG and IgM; they were excluded from the seroconversion calculation if either pre-travel anti-DENV IgG or IgM were positive...
November 2, 2016: American Journal of Tropical Medicine and Hygiene
keyword
keyword
115643
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"