keyword
MENU ▼
Read by QxMD icon Read
search

Zika virus vaccine

keyword
https://www.readbyqxmd.com/read/29157958/u-s-pregnant-women-s-knowledge-and-attitudes-about-behavioral-strategies-and-vaccines-to-prevent-zika-acquisition
#1
Lauren Dapena Fraiz, Ariel de Roche, Christine Mauro, Marina Catallozzi, Gregory D Zimet, Gilla K Shapiro, Susan L Rosenthal
INTRODUCTION: Zika virus infection during pregnancy can cause significant infant morbidity. Little is known about pregnant women's attitudes regarding behavioral strategies and hypothetical vaccination to prevent Zika infections and sequelae. METHODS: Pregnant women across the United States (N = 362) completed an online questionnaire regarding attitudes about Zika, including six behavioral prevention strategies (i.e., abstaining from sex, using condoms, not traveling to an area with Zika, their partner not traveling into an area with Zika, using mosquito repellant, wearing long pants and sleeves) and vaccination...
November 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29146711/ethics-health-policy-and-zika-from-emergency-to-global-epidemic
#2
Euzebiusz Jamrozik, Michael J Selgelid
Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barré syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation (PAHO), with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issues raised during the Zika epidemic, highlighting the PAHO ethics guidance and the role of ethics in emergency responses, before turning to ethical issues that are yet to be resolved...
November 16, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29145452/behavioral-climatic-and-environmental-risk-factors-for-zika-and-chikungunya-virus-infections-in-rio-de-janeiro-brazil-2015-16
#3
Trevon L Fuller, Guilherme Calvet, Camila Genaro Estevam, Jussara Rafael Angelo, Gbenga J Abiodun, Umme-Aiman Halai, Bianca De Santis, Patricia Carvalho Sequeira, Eliane Machado Araujo, Simone Alves Sampaio, Marco Cesar Lima de Mendonça, Allison Fabri, Rita Maria Ribeiro, Ryan Harrigan, Thomas B Smith, Claudia Raja Gabaglia, Patrícia Brasil, Ana Maria Bispo de Filippis, Karin Nielsen-Saines
The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#4
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29135369/t-cell-immunity-to-zika-and-dengue-viral-infections
#5
Jinsheng Wen, Sujan Shresta
The 2015-2016 Zika virus (ZIKV) outbreak in the Americas has brought this relatively unknown flavivirus into the spotlight as the etiologic agent of congenital Zika syndrome in newborns and, potentially, of Guillain-Barré syndrome in adults. ZIKV shares a high degree of amino acid sequence homology with the closely related flavivirus Dengue virus (DENV). Due to the paucity of research investigating T cell-mediated immune responses to ZIKV, the precise roles of T cells in protection against and pathogenesis of ZIKV infection are unclear...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29133118/functional-characterization-of-a-serine-protease-inhibitor-modulated-in-the-infection-of-the-aedes-aegypti-with-dengue-virus
#6
Tatiane Sanches Soares, Boris Luis Rodriguez Gonzalez, Ricardo José Soares Torquato, Francisco Jose Alves Lemos, André L Costa-da-Silva, Margareth de Lara Capurro Guimarães, Aparecida Sadae Tanaka
During feeding with blood meal, female Aedes aegypti can transmit infectious agents, such as dengue, yellow fever, chikungunya and Zika viruses. Dengue virus causes human mortality in tropical regions of the world, and there is no specific treatment or vaccine with maximum efficiency being used for these infections. In the vector-virus interaction, the production of several molecules is modulated by both mosquitoes and invading agents. However, little information is available about these molecules in the Ae...
November 10, 2017: Biochimie
https://www.readbyqxmd.com/read/29131357/zika-virus-what-we-need-to-know
#7
REVIEW
Farakh Javed, Khanzadi N Manzoor, Mubashar Ali, Irshad U Haq, Abid A Khan, Assad Zaib, Sobia Manzoor
Zika virus is one of the emerging viruses and is of significant threat to human health globally. It is a mosquito borne flavivirus similar to dengue, yellow fever, and West Nile viruses. It was reported about 5 decades ago and then it spreads to different parts of the world. Large outbreaks were reported on Yap Islands in 2007. Now it has gained wide attention globally by health communities. Major vector for virus transmission is Aedes aegypti mosquito. ZIKV infection is mostly asymptomatic but it is also responsible to cause mild influenza like illness to serious manifestations...
November 13, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29129917/dengue-virus-reactive-cd8-t-cells-mediate-cross-protection-against-subsequent-zika-virus-challenge
#8
Jinsheng Wen, Annie Elong Ngono, Jose Angel Regla-Nava, Kenneth Kim, Matthew J Gorman, Michael S Diamond, Sujan Shresta
Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1 (-/-) or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8(+) T cells predominantly mediate cross-protective responses to ZIKV...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29122384/strengthening-global-vaccine-access-for-adolescents-and-adults
#9
REVIEW
Angeline Nanni, Stefanie Meredith, Stephanie Gati, Karin Holm, Tom Harmon, Ann Ginsberg
Global immunization efforts to date have heavily focused on infants and children, with noted success on public health. Healthy adolescents and adults contribute to the economic growth and development of countries but efforts to ensure vaccine coverage for these groups receive inadequate global attention and resources. Emerging epidemics for a number of infectious diseases including Ebola, Zika, dengue, malaria and the continuing epidemics of tuberculosis and several sexually transmitted infections, including HIV, HPV and Hepatitis B, have high incidence and prevalence in adolescents and adults...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29116169/a-zika-vaccine-targeting-ns1-protein-protects-immunocompetent-adult-mice-in-a-lethal-challenge-model
#10
Aaron C Brault, Arban Domi, Erin M McDonald, Dalit Talmi-Frank, Nathanael McCurley, Rahul Basu, Harriet L Robinson, Michael Hellerstein, Nisha K Duggal, Richard A Bowen, Farshad Guirakhoo
Zika virus (ZIKV) is a mosquito-borne flavivirus that has rapidly extended its geographic range around the world. Its association with abnormal fetal brain development, sexual transmission, and lack of a preventive vaccine have constituted a global health concern. Designing a safe and effective vaccine requires significant caution due to overlapping geographical distribution of ZIKV with dengue virus (DENV) and other flaviviruses, possibly resulting in more severe disease manifestations in flavivirus immune vaccinees such as Antibody-Dependent Enhancement (ADE, a phenomenon involved in pathogenesis of DENV, and a risk associated with ZIKV vaccines using the envelope proteins as immunogens)...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109164/zika-virus-zikv-replication-is-substantially-inhibited-by-novel-favipiravir-and-interferon-alpha-combination-regimens
#11
Camilly P Pires de Mello, Xun Tao, Tae Hwan Kim, Jürgen B Bulitta, Jaime L Rodriquez, Justin J Pomeroy, Ashley N Brown
Zika virus (ZIKV) is a major public health concern due to its overwhelming spread into the Americas. Currently there are neither licensed vaccines nor antiviral therapies available for the treatment of ZIKV. We aimed to identify and rationally optimize effective therapeutic regimens for ZIKV by evaluating the antiviral potential of approved broad-spectrum antiviral agents favipiravir (FAV), interferon-alpha (IFN), and ribavirin (RBV) as single agent and combinations. For these studies, Vero cells were infected with ZIKV in the presence of increasing concentrations of FAV, IFN, or/and RBV for four days...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29099873/assessing-zika-virus-replication-and-the-development-of-zika-specific-antibodies-after-a-mid-gestation-viral-challenge-in-guinea-pigs
#12
Craig J Bierle, Claudia Fernández-Alarcón, Nelmary Hernandez-Alvarado, Jason C Zabeli, Bradley C Janus, Dira S Putri, Mark R Schleiss
Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. Animal models that accurately recapitulate congenital Zika syndrome are urgently needed for vaccine development and for the study of ZIKV pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29096005/management-of-zika-virus-in-pregnancy-a-review
#13
Helen Perry, Asma Khalil, Emma Aarons, Katherine Russell, Patrick O'Brien
Introduction/background: Since 2015, an epidemic of Zika virus spread across the Americas. This coincided with an increased incidence of microcephaly reported at birth in Brazil, with subsequent evidence of a causal association. Sources of data: Systemic reviews, observational studies, public health organizations. Areas of agreement: Zika virus causes microcephaly and brain abnormalities in infants born to mothers infected during or shortly before pregnancy...
October 31, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29094318/discovery-of-t-cell-driven-subunit-vaccines-from-zika-virus-genome-an-immunoinformatics-approach
#14
Dibyabhaba Pradhan, Monika Yadav, Rashi Verma, Noor Saba Khan, Lingaraja Jena, Arun Kumar Jain
The recent outbreaks of Zika virus and the absence of a specific therapy have necessitated to identify T-cell-stimulating antigenic peptides as potential subunit vaccine candidates. The translated ssRNA (+) genome of Zika virus was explored in EMBOSS antigenic and VaxiJen to predict 63 peptides as potential antigens. Three MHC-II binding peptide prediction tools, viz. NetMHCIIpan, PREDIVAC and immune epitope database (IEDB) were employed in consensus on 63 antigenic peptides to propose 14 T-helper cell epitopes...
November 1, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29051080/antiviral-activity-of-n-4-hydroxyphenyl-retinamide-4-hpr-against-zika-virus
#15
Jared D Pitts, Pi-Chun Li, Melissanne de Wispelaere, Priscilla L Yang
The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to prevent or treat ZIKV infection. We and others have previously identified N-(4-hydroxyphenyl) retinamide (fenretinide or 4-HPR) as an antiviral compound that inhibits dengue virus 2 (DV2) and other flaviviruses by limiting the steady-state accumulation of viral RNA. Here we show that 4-HPR potently inhibits ZIKV in mammalian cell culture and significantly reduces both serum viremia and brain viral burden in a murine model of ZIKV infection...
November 2017: Antiviral Research
https://www.readbyqxmd.com/read/29050846/zika-virus-what-where-from-and-where-to
#16
REVIEW
Kerri Basile, Jen Kok, Dominic E Dwyer
The significance of Zika virus as a clinically significant flavivirus has previously been under-recognised, until extensive outbreaks in Yap in 2007, French Polynesia in 2013 and the Americas since 2015. Although Zika virus infection is commonly asymptomatic or mild, emerging evidence suggests a strong link to microcephaly in babies and Guillain-Barré syndrome in adults. This article reviews the epidemiology, geographic distribution, basic virology, transmission, clinical presentation, potential complications, laboratory diagnosis, treatment and prevention of Zika virus infection...
October 16, 2017: Pathology
https://www.readbyqxmd.com/read/29037978/expected-immunizations-and-health-protection-for-hajj-and-umrah-2018-an-overview
#17
REVIEW
Jaffar A Al-Tawfiq, Philippe Gautret, Ziad A Memish
BACKGROUND: The annual Hajj and Umrah are one of the largest recurring religious mass gatherings across the globe drawing pilgrims from more than 185 countries. The living circumstances and activities of the pilgrims may create an environment for the occurrence and spread of communicable diseases. Each year, the Health authority of the Kingdom of Saudi Arabia, in coordination with international health authorities, updates health requirements for pilgrims. The Hajj for 2017 took place from August 24 to September 5, 2017...
October 14, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29037541/zika-virus-an-emerging-challenge-for-obstetrics-and-gynecology
#18
REVIEW
Jhe-Jhih Lin, Ting-Yu Chin, Chih-Ping Chen, Hong-Lin Chan, Tzong-Yuan Wu
Microcephaly is a rare birth defect, however, the re-emerging mosquito and sexual transmitted flavivirus, Zika virus (ZIKV), had changed the situation and caused an urgent challenge for the obstetrics and gynecology. This review will brief summarize the epidemiology and virology of ZIKV. And compared the animal models that had developed for the ZIKV infections. These animal models will be benefit for the development of vaccines and anti-ZIKV drugs. Furthermore, the genes that are involved in the causation of microcephaly were also summarized...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#19
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29033372/chloroquine-a-fda-approved-drug-prevents-zika-virus-infection-and-its-associated-congenital-microcephaly-in-mice
#20
Chunfeng Li, Xingliang Zhu, Xue Ji, Natalie Quanquin, Yong-Qiang Deng, Min Tian, Roghiyh Aliyari, Xiangyang Zuo, Ling Yuan, Shabbir Khan Afridi, Xiao-Feng Li, Jae U Jung, Karin Nielsen-Saines, Frank Xiao-Feng Qin, Cheng-Feng Qin, Zhiheng Xu, Genhong Cheng
Zika virus (ZIKV) has become a global public health emergency due to its rapidly expanding range and its ability to cause severe congenital defects such as microcephaly. However, there are no FDA-approved therapies or vaccines against ZIKV infection. Through our screening of viral entry inhibitors, we found that chloroquine (CQ), a commonly used antimalarial and a FDA-approved drug that has also been repurposed against other pathogens, could significantly inhibit ZIKV infection in vitro, by blocking virus internalization...
October 2017: EBioMedicine
keyword
keyword
115642
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"