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https://www.readbyqxmd.com/read/27917593/%C3%AE-markov-model-for-longitudinal-studies-with-incomplete-dichotomous-outcomes
#1
Orestis Efthimiou, Nicky Welton, Myrto Samara, Stefan Leucht, Georgia Salanti
Missing outcome data constitute a serious threat to the validity and precision of inferences from randomized controlled trials. In this paper, we propose the use of a multistate Markov model for the analysis of incomplete individual patient data for a dichotomous outcome reported over a period of time. The model accounts for patients dropping out of the study and also for patients relapsing. The time of each observation is accounted for, and the model allows the estimation of time-dependent relative treatment effects...
December 5, 2016: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/27900573/erratum-to-molecular-dissection-of-placental-malaria-protein-var2csa-interaction-with-a-chemo-enzymatically-synthesized-chondroitin-sulfate-library
#2
Nobuo Sugiura, Thomas Mandel Clausen, Tatsumasa Shioiri, Tobias Gustavsson, Hideto Watanabe, Ali Salanti
No abstract text is available yet for this article.
November 30, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27864068/bibliographic-study-showed-improving-statistical-methodology-of-network-meta-analyses-published-between-1999-and-2015
#3
Maria Petropoulou, Adriani Nikolakopoulou, Areti-Angeliki Veroniki, Patricia Rios, Afshin Vafaei, Wasifa Zarin, Myrsini Giannatsi, Shannon Sullivan, Andrea C Tricco, Anna Chaimani, Matthias Egger, Georgia Salanti
OBJECTIVE: To assess the characteristics and core statistical methodology specific to network meta-analyses (NMAs) in clinical research articles. STUDY DESIGN AND SETTING: We searched Medline, Embase and the Cochrane Database of Systematic Reviews from inception until April 14, 2015 for NMAs of randomized controlled trials (RCTs) including at least four different interventions. Two reviewers independently screened potential studies, while data abstraction was performed by a single reviewer and verified by a second...
November 15, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27825348/bacterial-superglue-generates-a-full-length-circumsporozoite-protein-virus-like-particle-vaccine-capable-of-inducing-high-and-durable-antibody-responses
#4
Christoph M Janitzek, Sungwa Matondo, Susan Thrane, Morten A Nielsen, Reginald Kavishe, Steve B Mwakalinga, Thor G Theander, Ali Salanti, Adam F Sander
BACKGROUND: Malaria, caused by Plasmodium falciparum, continues to have a devastating impact on global health, emphasizing the great need for a malaria vaccine. The circumsporozoite protein (CSP) is an attractive target for a malaria vaccine, and forms a major component of RTS,S, the most clinically advanced malaria vaccine. The clinical efficacy of RTS,S has been moderate, yet has demonstrated the viability of a CSP-based malaria vaccine. In this study, a vaccine comprised of the full-length CSP antigen presented on a virus-like particle (VLP) is produced using a split-intein conjugation system (SpyTag/SpyCatcher) and the immunogenicity is tested in mice...
November 8, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27814765/antibody-responses-to-the-full-length-var2csa-and-its-dbl-domains-in-cameroonian-children-and-teenagers
#5
Barriere A Y Fodjo, Njika Atemnkeng, Livo Esemu, Emile K Yuosembom, Isabella A Quakyi, Viviane H M Tchinda, Joseph Smith, Ali Salanti, Jude Bigoga, Diane W Taylor, Rose G F Leke, Anna Babakhanyan
BACKGROUND: Antigenic variation of Plasmodium falciparum erythrocyte membrane protein 1 is a key parasite mechanism for immune evasion and parasite survival. It is assumed that the number of parasites expressing the same var gene must reach high enough numbers before the host can produce detectable levels of antibodies (Ab) to the variant. VAR2CSA is a protein coded for by one of 60 var genes that is expressed on the surface of infected erythrocytes (IE) and mediates IE binding to the placenta...
November 4, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27726982/placebo-response-rates-in-antidepressant-trials-a-systematic-review-of-published-and-unpublished-double-blind-randomised-controlled-studies
#6
Toshi A Furukawa, Andrea Cipriani, Lauren Z Atkinson, Stefan Leucht, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti
BACKGROUND: Previous studies have shown that placebo response rates in antidepressant trials have been increasing since the 1970s. However, these studies have been based on outdated or limited datasets and have used inappropriate statistical methods. We did a systematic review of placebo-controlled randomised controlled trials of antidepressants to examine associations between placebo-response rates and study and patient characteristics. METHODS: In this systematic review, we searched for published and unpublished double-blind randomised placebo-controlled trials of first-generation and second-generation antidepressants for acute treatment of major depression in adults (update: Jan 8, 2016)...
October 7, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27587588/continuously-updated-network-meta-analysis-and-statistical-monitoring-for-timely-decision-making
#7
Adriani Nikolakopoulou, Dimitris Mavridis, Matthias Egger, Georgia Salanti
Pairwise and network meta-analysis (NMA) are traditionally used retrospectively to assess existing evidence. However, the current evidence often undergoes several updates as new studies become available. In each update recommendations about the conclusiveness of the evidence and the need of future studies need to be made. In the context of prospective meta-analysis future studies are planned as part of the accumulation of the evidence. In this setting, multiple testing issues need to be taken into account when the meta-analysis results are interpreted...
September 1, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27556547/placental-sequestration-of-plasmodium-falciparum-malaria-parasites-is-mediated-by-the-interaction-between-var2csa-and-chondroitin-sulfate-a-on-syndecan-1
#8
Marina Ayres Pereira, Thomas Mandel Clausen, Caroline Pehrson, Yang Mao, Mafalda Resende, Mads Daugaard, Anders Riis Kristensen, Charlotte Spliid, Line Mathiesen, Lisbeth E Knudsen, Peter Damm, Thor G Theander, Stefan R Hansson, Morten A Nielsen, Ali Salanti
During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the placenta, causing health problems for both the mother and fetus. The specific adherence is mediated by the VAR2CSA protein, which binds to placental chondroitin sulfate (CS) on chondroitin sulfate proteoglycans (CSPGs) in the placental syncytium. However, the identity of the CSPG core protein and the cellular impact of the interaction have remain elusive. In this study we identified the specific CSPG core protein to which the CS is attached, and characterized its exact placental location...
August 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27487843/an-overview-of-methods-for-network-meta-analysis-using-individual-participant-data-when-do-benefits-arise
#9
Thomas Pa Debray, Ewoud Schuit, Orestis Efthimiou, Johannes B Reitsma, John Pa Ioannidis, Georgia Salanti, Karel Gm Moons
Network meta-analysis (NMA) is a common approach to summarizing relative treatment effects from randomized trials with different treatment comparisons. Most NMAs are based on published aggregate data (AD) and have limited possibilities for investigating the extent of network consistency and between-study heterogeneity. Given that individual participant data (IPD) are considered the gold standard in evidence synthesis, we explored statistical methods for IPD-NMA and investigated their potential advantages and limitations, compared with AD-NMA...
August 2, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27441183/real-time-and-label-free-determination-of-ligand-binding-kinetics-to-primary-cancer-tissue-specimens-a-novel-tool-for-the-assessment-of-biomarker-targeting
#10
Thomas Mandel Clausen, Marina Ayres Pereira, Htoo Zarni Oo, Mafalda Resende, Tobias Gustavson, Yang Mao, Nobuo Sugiura, Janet Liew, Ladan Fazli, Thor G Theander, Mads Daugaard, Ali Salanti
In clinical oncology, diagnosis and evaluation of optimal treatment strategies are mostly based on histopathological examination combined with immunohistochemical (IHC) expression analysis of cancer-associated antigens in formalin fixed paraffin-embedded (FFPE) tissue biopsies. However, informative IHC analysis depends on both the specificity and affinity of the binding reagent, which are inherently difficult to quantify in situ. Here we describe a label-free method that allows for the direct and real-time assessment of molecular binding kinetics in situ on FFPE tissue specimens using quartz crystal microbalance (QCM) enabled biosensor technology...
July 2016: Sensing and Bio-Sensing Research
https://www.readbyqxmd.com/read/27435721/network-meta-analyses-should-be-the-highest-level-of-evidence-in-treatment-guidelines
#11
EDITORIAL
Stefan Leucht, Anna Chaimani, Andrea S Cipriani, John M Davis, Toshi A Furukawa, Georgia Salanti
No abstract text is available yet for this article.
September 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27401359/comparative-efficacy-and-acceptability-of-first-generation-and-second-generation-antidepressants-in-the-acute-treatment-of-major-depression-protocol-for-a-network-meta-analysis
#12
Toshi A Furukawa, Georgia Salanti, Lauren Z Atkinson, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Anna Chaimani, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aya Suganuma, Norio Watanabe, Sarah Stockton, John R Geddes, Andrea Cipriani
INTRODUCTION: Many antidepressants are indicated for the treatment of major depression. Two network meta-analyses have provided the most comprehensive assessments to date, accounting for both direct and indirect comparisons; however, these reported conflicting interpretation of results. Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression...
2016: BMJ Open
https://www.readbyqxmd.com/read/27389906/transcatheter-aortic-valve-implantation-vs-surgical-aortic-valve-replacement-for-treatment-of-severe-aortic-stenosis-a-meta-analysis-of-randomized-trials
#13
George C M Siontis, Fabien Praz, Thomas Pilgrim, Dimitris Mavridis, Subodh Verma, Georgia Salanti, Lars Søndergaard, Peter Jüni, Stephan Windecker
AIMS: In view of the currently available evidence from randomized trials, we aimed to compare the collective safety and efficacy of transcatheter aortic valve implantation (TAVI) vs. surgical aortic valve replacement (SAVR) across the spectrum of risk and in important subgroups. METHODS AND RESULTS: Trials comparing TAVI vs. SAVR were identified through Medline, Embase, and Cochrane databases. The primary outcome was death from any cause at 2 years. We performed random-effects meta-analyses to combine the available evidence and to evaluate the effect in different subgroups...
July 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27287227/molecular-dissection-of-placental-malaria-protein-var2csa-interaction-with-a-chemo-enzymatically-synthesized-chondroitin-sulfate-library
#14
Nobuo Sugiura, Thomas Mandel Clausen, Tatsumasa Shioiri, Tobias Gustavsson, Hideto Watanabe, Ali Salanti
Placental malaria, a serious infection caused by the parasite Plasmodium falciparum, is characterized by the selective accumulation of infected erythrocytes (IEs) in the placentas of the pregnant women. Placental adherence is mediated by the malarial VAR2CSA protein, which interacts with chondroitin sulfate (CS) proteoglycans present in the placental tissue. CS is a linear acidic polysaccharide composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-galactosamine that are modified by sulfate groups at different positions...
June 10, 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27230523/adhesion-of-plasmodium-falciparum-infected-erythrocytes-in-ex-vivo-perfused-placental-tissue-a-novel-model-of-placental-malaria
#15
Caroline Pehrson, Line Mathiesen, Kristine K Heno, Ali Salanti, Mafalda Resende, Ron Dzikowski, Peter Damm, Stefan R Hansson, Christopher L King, Henning Schneider, Christian W Wang, Thomas Lavstsen, Thor G Theander, Lisbeth E Knudsen, Morten A Nielsen
BACKGROUND: Placental malaria occurs when Plasmodium falciparum infected erythrocytes sequester in the placenta. Placental parasite isolates bind to chondroitin sulphate A (CSA) by expression of VAR2CSA on the surface of infected erythrocytes, but may sequester by other VAR2CSA mediated mechanisms, such as binding to immunoglobulins. Furthermore, other parasite antigens have been associated with placental malaria. These findings have important implications for placental malaria vaccine design...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27200533/evaluating-the-quality-of-evidence-from-a-network-meta-analysis
#16
J P Higgins, C Del Giovane, A Chaimani, D M Caldwell, G Salanti
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27147393/cognitive-behavioural-analysis-system-of-psychotherapy-cbasp-a-drug-or-their-combination-differential-therapeutics-for-persistent-depressive-disorder-a-study-protocol-of-an-individual-participant-data-network-meta-analysis
#17
Toshi A Furukawa, Elisabeth Schramm, Erica S Weitz, Georgia Salanti, Orestis Efthimiou, Johannes Michalak, Norio Watanabe, Andrea Cipriani, Martin B Keller, James H Kocsis, Daniel N Klein, Pim Cuijpers
INTRODUCTION: Despite important advances in psychological and pharmacological treatments of persistent depressive disorders in the past decades, their responses remain typically slow and poor, and differential responses among different modalities of treatments or their combinations are not well understood. Cognitive-Behavioural Analysis System of Psychotherapy (CBASP) is the only psychotherapy that has been specifically designed for chronic depression and has been examined in an increasing number of trials against medications, alone or in combination...
2016: BMJ Open
https://www.readbyqxmd.com/read/27117585/bacterial-superglue-enables-easy-development-of-efficient-virus-like-particle-based-vaccines
#18
Susan Thrane, Christoph M Janitzek, Sungwa Matondo, Mafalda Resende, Tobias Gustavsson, Willem Adriaan de Jongh, Stine Clemmensen, Will Roeffen, Marga van de Vegte-Bolmer, Geert Jan van Gemert, Robert Sauerwein, John T Schiller, Morten A Nielsen, Thor G Theander, Ali Salanti, Adam F Sander
BACKGROUND: Virus-like particles (VLPs) represent a significant advance in the development of subunit vaccines, combining high safety and efficacy. Their particulate nature and dense repetitive subunit organization makes them ideal scaffolds for display of vaccine antigens. Traditional approaches for VLP-based antigen display require labor-intensive trial-and-error optimization, and often fail to generate dense antigen display. Here we utilize the split-intein (SpyTag/SpyCatcher) conjugation system to generate stable isopeptide bound antigen-VLP complexes by simply mixing of the antigen and VLP components...
2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27074861/using-the-contribution-matrix-to-evaluate-complex-study-limitations-in-a-network-meta-analysis-a-case-study-of-bipolar-maintenance-pharmacotherapy-review
#19
Toshi A Furukawa, Tomofumi Miura, Anna Chaimani, Stefan Leucht, Andrea Cipriani, Hisashi Noma, Hiroshi Mitsuyasu, Shegenobu Kanba, Georgia Salanti
BACKGROUND: Limitations in the primary studies constitute one important factor to be considered in the grading of recommendations assessment, development, and evaluation (GRADE) system of rating quality of evidence. However, in the network meta-analysis (NMA), such evaluation poses a special challenge because each network estimate receives different amounts of contributions from various studies via direct as well as indirect routes and because some biases have directions whose repercussion in the network can be complicated...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27071857/psychological-therapies-for-panic-disorder-with-or-without-agoraphobia-in-adults-a-network-meta-analysis
#20
REVIEW
Alessandro Pompoli, Toshi A Furukawa, Hissei Imai, Aran Tajika, Orestis Efthimiou, Georgia Salanti
BACKGROUND: Panic disorder is characterised by the presence of recurrent unexpected panic attacks, discrete periods of fear or anxiety that have a rapid onset and include symptoms such as racing heart, chest pain, sweating and shaking. Panic disorder is common in the general population, with a lifetime prevalence of 1% to 4%. A previous Cochrane meta-analysis suggested that psychological therapy (either alone or combined with pharmacotherapy) can be chosen as a first-line treatment for panic disorder with or without agoraphobia...
2016: Cochrane Database of Systematic Reviews
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