Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Konstantina Chalkou, Tasnim Hamza, Pascal Benkert, Jens Kuhle, Chiara Zecca, Gabrielle Simoneau, Fabio Pellegrini, Andrea Manca, Matthias Egger, Georgia Salanti
Some patients benefit from a treatment while others may do so less or do not benefit at all. We have previously developed a two-stage network meta-regression prediction model that synthesized randomized trials and evaluates how treatment effects vary across patient characteristics. In this article, we extended this model to combine different sources of types in different formats: aggregate data (AD) and individual participant data (IPD) from randomized and non-randomized evidence. In the first stage, a prognostic model is developed to predict the baseline risk of the outcome using a large cohort study...
March 19, 2024: Research Synthesis Methods
#2
JOURNAL ARTICLE
Ethan Sahker, Toshi A Furukawa, Yan Luo, Manuela L Ferreira, Kaori Okazaki, Astrid Chevance, Sarah Markham, Roger Ede, Stefan Leucht, Andrea Cipriani, Georgia Salanti
BACKGROUND: Approximately 30% of patients experience substantial improvement in depression after 2 months without treatment, and 45% with antidepressants. The smallest worthwhile difference (SWD) refers to an intervention's smallest beneficial effect over a comparison patients deem worthwhile given treatment burdens (harms, expenses and inconveniences), but is undetermined for antidepressants. OBJECTIVE: Estimating the SWD of commonly prescribed antidepressants for depression compared to no treatment...
January 8, 2024: BMJ Ment Health
#3
JOURNAL ARTICLE
Livia Puljak, Małgorzata M Bala, Joanna Zając, Tomislav Meštrović, Sandra Buttiġieġ, Mary Yanakoulia, Matthias Briel, Carole Lunny, Wiktoria Lesniak, Tina Poklepović Peričić, Pablo Alonso-Coello, Mike Clarke, Benjamin Djulbegovic, Gerald Gartlehner, Konstantinos Giannakou, Anne-Marie Glenny, Claire Glenton, Gordon Guyatt, Lars G Hemkens, John P A Ioannidis, Roman Jaeschke, Karsten Juhl Jørgensen, Carolina Castro Martins-Pfeifer, Ana Marušić, Lawrence Mbuagbaw, Jose Francisco Meneses Echavez, David Moher, Barbara Nussbaumer-Streit, Matthew J Page, Giordano Pérez-Gaxiola, Karen A Robinson, Georgia Salanti, Ian J Saldanha, Jelena Savović, James Thomas, Andrea C Tricco, Peter Tugwell, Joost van Hoof, Dawid Pieper
OBJECTIVES: Evidence-based research (EBR) is the systematic and transparent use of prior research to inform a new study so that it answers questions that matter in a valid, efficient, and accessible manner. This study surveyed experts about existing (e.g. citation analysis) and new methods for monitoring EBR and collected ideas about implementing these methods. STUDY DESIGN AND SETTING: We conducted a cross-sectional study via an online survey between November 2022 and March 2023...
January 5, 2024: Journal of Clinical Epidemiology
#4
JOURNAL ARTICLE
Andrea Cipriani, Adeola Agunbiade, Georgia Salanti
No abstract text is available yet for this article.
January 13, 2024: Lancet
#5
JOURNAL ARTICLE
Virginia Chiocchia, Toshi A Furukawa, Johannes Schneider-Thoma, Spyridon Siafis, Andrea Cipriani, Stefan Leucht, Georgia Salanti
BACKGROUND: The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking metrics calculated from a single outcome. Some approaches have been proposed in the literature to account for multiple outcomes and individual preferences, such as the coverage area inside a spie chart, that, however, does not account for a trade-off between efficacy and safety outcomes...
November 11, 2023: Systematic Reviews
#6
JOURNAL ARTICLE
Justin Doritchamou, Morten A Nielsen, Arnaud Chêne, Nicola K Viebig, Lynn E Lambert, Adam F Sander, Jean-Philippe Semblat, Sophia Hundt, Sachy Orr-Gonzalez, Christoph Mikkel Janitzek, Alicia J Spiegel, Stine B Clemmensen, Marvin L Thomas, Martha C Nason, Maryonne Snow-Smith, Emma K Barnafo, Joseph Shiloach, Beth B Chen, Steven Nadakal, Kendrick Highsmith, Tarik Ouahes, Solomon Conteh, Ankur Sharma, Holly Torano, Brandi Butler, Karine Reiter, Kelly M Rausch, Puthupparampil V Scaria, Charles Anderson, David L Narum, Ali Salanti, Michal Fried, Thor G Theander, Benoit Gamain, Patrick E Duffy
Placental malaria vaccines (PMVs) are being developed to prevent severe sequelae of placental malaria (PM) in pregnant women and their offspring. The leading candidate vaccine antigen VAR2CSA mediates parasite binding to placental receptor chondroitin sulfate A (CSA). Despite promising results in small animal studies, recent human trials of the first two PMV candidates (PAMVAC and PRIMVAC) generated limited cross-reactivity and cross-inhibitory activity to heterologous parasites. Here we immunized Aotus nancymaae monkeys with three PMV candidates (PAMVAC, PRIMVAC and ID1-ID2a_M1010) adjuvanted with Alhydrogel, and exploited the model to investigate boosting of functional vaccine responses during PM episodes as well as with nanoparticle antigens...
November 6, 2023: Lab Animal
#7
JOURNAL ARTICLE
Diana Buitrago-Garcia, Georgia Salanti, Nicola Low
BACKGROUND: Monitoring of HIV and sexually transmitted infection (STI) prevention is important for guiding national sexual health programmes for both the general population and key populations. The objectives of this study were to examine trends and patterns of condom use at last intercourse and lifetime HIV testing in 2007, 2012 and 2017 in Switzerland, and to explore factors associated with these behaviours in men and women with opposite-sex partners and with same sex partners. METHODS: We analysed data from the 2007, 2012 and 2017 Swiss Health Survey...
November 3, 2023: BMC Public Health
#8
JOURNAL ARTICLE
Thomy Tonia, Diana Buitrago-Garcia, Natalie Luise Peter, Cristina Mesa-Vieira, Tianjing Li, Toshi A Furukawa, Andrea Cipriani, Stefan Leucht, Nicola Low, Georgia Salanti
OBJECTIVE: There is no standard tool for assessing risk of bias (RoB) in prevalence studies. For the purposes of a living systematic review during the COVID-19 pandemic, we developed a tool to evaluate RoB in studies measuring the prevalence of mental health disorders (RoB-PrevMH) and tested inter-rater reliability. METHODS: We decided on items and signalling questions to include in RoB-PrevMH through iterative discussions. We tested the reliability of assessments by different users with two sets of prevalence studies...
October 2023: BMJ Ment Health
#9
JOURNAL ARTICLE
Virginia Chiocchia, Alexander Holloway, Georgia Salanti
Network meta-analysis compares multiple interventions and estimates the relative treatment effects between all interventions, combining both direct and indirect evidence. Recently, a framework was developed to assess the Risk Of Bias due to Missing Evidence in Network meta-analysis (ROB-MEN) which is part of the more comprehensive framework to evaluate the Confidence In the evidence for Network Meta-Analysis (CINeMA). To produce an overall risk of bias judgement for each network estimate, ROB-MEN: performs an assessment of the bias due to missing evidence in each possible pairwise comparison; combines the assessment with the contribution from the direct pairwise comparisons; considers the potential for small-study effects...
October 7, 2023: BMC Medical Research Methodology
#10
JOURNAL ARTICLE
Leonie Heron, Diana Buitrago-Garcia, Aziz Mert Ipekci, Rico Baumann, Hira Imeri, Georgia Salanti, Michel Jacques Counotte, Nicola Low
BACKGROUND: The covid-19 pandemic has highlighted the role of living systematic reviews. The speed of evidence generated during the covid-19 pandemic accentuated the challenges of managing high volumes of research literature. METHODS: In this article, we summarise the characteristics of ongoing living systematic reviews on covid-19, and we follow a life cycle approach to describe key steps in a living systematic review. RESULTS: We identified 97 living systematic reviews on covid-19, published up to 7th November 2022, which focused mostly on the effects of pharmacological interventions (n = 46, 47%) or the prevalence of associated conditions or risk factors (n = 30, 31%)...
September 2, 2023: Systematic Reviews
#11
JOURNAL ARTICLE
Jessica Pihl, Thomas M Clausen, Jiarong Zhou, Nishta Krishnan, Maj S Ørum-Madsen, Tobias Gustavsson, Robert Dagil, Mads Daugaard, Swati Choudhary, Camilla Foged, Jeffrey D Esko, Liangfang Zhang, Ronnie H Fang, Ali Salanti
Malaria infected erythrocytes utilize the parasite protein VAR2CSA to bind to a unique presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly, many cancers express a similar form of CS, thereby termed oncofetal CS (ofCS). The distinctive tropism of malaria infected erythrocytes and the identification of oncofetal CS, therefore, represent potentially potent tools for cancer targeting. Here we describe an intriguing drug delivery platform that effectively mimics infected erythrocytes and their specificity for ofCS...
July 12, 2023: ACS Nano
#12
JOURNAL ARTICLE
Yan Luo, Konstantina Chalkou, Satoshi Funada, Georgia Salanti, Toshi A Furukawa
IMPORTANCE: Current evidence remains ambiguous regarding whether biologics should be added to conventional treatment of rheumatoid arthritis for specific patients, which may cause potential overuse or treatment delay. OBJECTIVES: To estimate the benefit of adding biologics to conventional antirheumatic drugs for the treatment of rheumatoid arthritis given baseline characteristics. DATA SOURCES: Cochrane CENTRAL, Scopus, MEDLINE, and the World Health Organization International Clinical Trials Registry Platform were searched for articles published from database inception to March 2, 2022...
June 1, 2023: JAMA Network Open
#13
JOURNAL ARTICLE
Melanie R Walker, Manja Idorn, Anja Bennett, Max Søgaard, Ali Salanti, Sisse B Ditlev, Lea Barfod
BACKGROUND: The development of vaccine candidates for COVID-19, and the administration of booster vaccines, has meant a significant reduction in COVID-19 related deaths world-wide and the easing of global restrictions. However, new variants of SARS-CoV-2 have emerged with less susceptibility to vaccine induced immunity leading to breakthrough infections among vaccinated people. It is generally acknowledged that immunoglobulins play the major role in immune-protection, primarily through binding to the SARS-COV-2 receptor binding domain (RBD) and thereby inhibiting viral binding to the ACE2 receptor...
June 2023: Immunity, Inflammation and Disease
#14
JOURNAL ARTICLE
Qiang Liu, Edoardo Giuseppe Ostinelli, Franco De Crescenzo, Zhenpeng Li, Anneka Tomlinson, Georgia Salanti, Andrea Cipriani, Orestis Efthimiou
OBJECTIVE: When developing prediction models, researchers commonly employ a single model which uses all the available data ( end-to-end approach). Alternatively, a similarity-based approach has been previously proposed, in which patients with similar clinical characteristics are first grouped into clusters, then prediction models are developed within each cluster. The potential advantage of the similarity-based approach is that it may better address heterogeneity in patient characteristics...
June 2023: BMJ Ment Health
#15
JOURNAL ARTICLE
Andrea Cipriani, Soraya Seedat, Lea Milligan, Georgia Salanti, Malcolm Macleod, Janna Hastings, James Thomas, Susan Michie, Toshi A Furukawa, David Gilbert, Karla Soares-Weiser, Carmen Moreno, Stefan Leucht, Matthias Egger, Parisa Mansoori, James M Barker, Spyridon Siafis, Edoardo Giuseppe Ostinelli, Robert McCutcheon, Simonne Wright, Matilda Simpson, Olufisayo Elugbadebo, Virginia Chiocchia, Thomy Tonia, Rania Elgarf, Ayse Kurtulmus, Emily Sena, Ouma Simple, Niall Boyce, Sophie Chung, Anjuli Sharma, Miranda Wolpert, Jennifer Potts, Julian H Elliott
In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference in practice, as well as in predicting which treatments will work for whom and in what contexts. To intervene early in the process and deliver optimal care to patients, we need to understand the underlying mechanisms of mental health conditions, develop safe and effective interventions that target these mechanisms, and improve our capabilities in timely diagnosis and reliable prediction of symptom trajectories...
June 2023: BMJ Ment Health
#16
JOURNAL ARTICLE
Shahar Hayet, Mnar Ghrayeb, David N Azulay, Zohar Shpilt, Edit Y Tshuva, Liraz Chai
Biofilms are surface or interface-associated communities of bacterial cells, embedded in a self-secreted extracellular matrix (ECM). Cells in biofilms are 100-1000 times more resistant to antibiotic treatment relative to planktonic cells due to various reasons, including the ECM acting as a diffusion barrier to antibiotic molecules, the presence of persister cells that divide slowly and are less susceptible to cell-wall targeting drugs, and the activation of efflux pumps in response to antibiotic stress. In this study we tested the effect of two titanium(iv) complexes that have been previously reported as potent and non-toxic anticancer chemotherapeutic agents on Bacillus subtilis cells in culture and in biofilm forming conditions...
May 25, 2023: RSC medicinal chemistry
#17
RANDOMIZED CONTROLLED TRIAL
Urs Fischer, Masatoshi Koga, Daniel Strbian, Mattia Branca, Stefanie Abend, Sven Trelle, Maurizio Paciaroni, Götz Thomalla, Patrik Michel, Krassen Nedeltchev, Leo H Bonati, George Ntaios, Thomas Gattringer, Else-Charlotte Sandset, Peter Kelly, Robin Lemmens, P N Sylaja, Diana Aguiar de Sousa, Natan M Bornstein, Zuzana Gdovinova, Takeshi Yoshimoto, Marjaana Tiainen, Helen Thomas, Manju Krishnan, Gek C Shim, Christoph Gumbinger, Jochen Vehoff, Liqun Zhang, Kosuke Matsuzono, Espen Kristoffersen, Philippe Desfontaines, Peter Vanacker, Angelika Alonso, Yusuke Yakushiji, Caterina Kulyk, Dimitri Hemelsoet, Sven Poli, Ana Paiva Nunes, Nicoletta Caracciolo, Peter Slade, Jelle Demeestere, Alexander Salerno, Markus Kneihsl, Timo Kahles, Daria Giudici, Kanta Tanaka, Silja Räty, Rea Hidalgo, David J Werring, Martina Göldlin, Marcel Arnold, Cecilia Ferrari, Seraina Beyeler, Christian Fung, Bruno J Weder, Turgut Tatlisumak, Sabine Fenzl, Beata Rezny-Kasprzak, Arsany Hakim, Georgia Salanti, Claudio Bassetti, Jan Gralla, David J Seiffge, Thomas Horvath, Jesse Dawson
BACKGROUND: The effect of early as compared with later initiation of direct oral anticoagulants (DOACs) in persons with atrial fibrillation who have had an acute ischemic stroke is unclear. METHODS: We performed an investigator-initiated, open-label trial at 103 sites in 15 countries. Participants were randomly assigned in a 1:1 ratio to early anticoagulation (within 48 hours after a minor or moderate stroke or on day 6 or 7 after a major stroke) or later anticoagulation (day 3 or 4 after a minor stroke, day 6 or 7 after a moderate stroke, or day 12, 13, or 14 after a major stroke)...
June 29, 2023: New England Journal of Medicine
#18
JOURNAL ARTICLE
Mikail Gögenur, Lukas Balsevicius, Mustafa Bulut, Nesibe Colak, Tobias Freyberg Justesen, Anne-Marie Kanstrup Fiehn, Marianne Bøgevang Jensen, Kathrine Høst-Rasmussen, Britt Cappelen, Shruti Gaggar, Asma Tajik, Jawad Ahmad Zahid, Astrid Louise Bjørn Bennedsen, Tommaso Del Buono D'Ondes, Hans Raskov, Susanne Gjørup Sækmose, Lasse Bremholm Hansen, Ali Salanti, Susanne Brix, Ismail Gögenur
BACKGROUND: In colorectal cancer, the effects of immune checkpoint inhibitors are mostly limited to patients with deficient mismatch repair tumors, characterized by a high grade infiltration of CD8+T cells. Interventions aimed at increasing intratumoral CD8+T-cell infiltration in proficient mismatch repair tumors are lacking. METHODS: We conducted a proof of concept phase 1/2 clinical trial, where patients with non-metastasizing sigmoid or rectal cancer, scheduled for curative intended surgery, were treated with an endoscopic intratumorally administered neoadjuvant influenza vaccine...
May 2023: Journal for Immunotherapy of Cancer
#19
JOURNAL ARTICLE
Stefan Leucht, Johannes Schneider-Thoma, Angelika Burschinski, Natalie Peter, Dongfang Wang, Shimeng Dong, Maximilian Huhn, Adriani Nikolakopoulou, Georgia Salanti, John M Davis
Most acute phase antipsychotic drug trials in schizophrenia last only a few weeks, but patients must usually take these drugs much longer. We examined the long-term efficacy of antipsychotic drugs in acutely ill patients using network meta-analysis. We searched the Cochrane Schizophrenia Group register up to March 6, 2022 for randomized, blinded trials of at least 6-month duration on all second-generation and 18 first-generation antipsychotics. The primary outcome was change in overall symptoms of schizophrenia; secondary outcomes were all-cause discontinuation; change in positive, negative and depressive symptoms; quality of life, social functioning, weight gain, antiparkinson medication use, akathisia, serum prolactin level, QTc prolongation, and sedation...
June 2023: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
#20
JOURNAL ARTICLE
Nanna Skeltved, Mie A Nordmaj, Nicolai T Berendtsen, Robert Dagil, Emilie M R Stormer, Nader Al-Nakouzi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tobias Gustavsson, Swati Choudhary, Ismail Gögenur, Jan P Christensen, Thor G Theander, Mads Daugaard, Ali Salanti, Morten A Nielsen
BACKGROUND: The malaria protein VAR2CSA binds oncofetal chondroitin sulfate (ofCS), a unique chondroitin sulfate, expressed on almost all mammalian cancer cells. Previously, we produced a bispecific construct targeting ofCS and human T cells based on VAR2CSA and anti-CD3 (V-aCD3Hu ). V-aCD3Hu showed efficacy against xenografted tumors in immunocompromised mice injected with human immune cells at the tumor site. However, the complex effects potentially exerted by the immune system as a result of the treatment cannot occur in mice without an immune system...
April 28, 2023: Journal of Experimental & Clinical Cancer Research: CR
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
