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https://www.readbyqxmd.com/read/29661376/comparing-interventions-with-network-meta-analysis
#1
Matthew K Bagg, Georgia Salanti, James H McAuley
No abstract text is available yet for this article.
April 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29628364/antidepressants-might-work-for-people-with-major-depression-where-do-we-go-from-here
#2
Andrea Cipriani, Georgia Salanti, Toshi A Furukawa, Matthias Egger, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Lauren Z Atkinson, Anna Chaimani, Julian P T Higgins, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
No abstract text is available yet for this article.
April 5, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29540411/psychological-interventions-for-positive-symptoms-in-schizophrenia-protocol-for-a-network-meta-analysis-of-randomised-controlled-trials
#3
Irene Bighelli, Georgia Salanti, Cornelia Reitmeir, Sofia Wallis, Corrado Barbui, Toshi A Furukawa, Stefan Leucht
INTRODUCTION: There is rising awareness that we need multidisciplinary approaches integrating psychological treatments for schizophrenia, but a comprehensive evidence based on their relative efficacy is lacking. We will conduct a network meta-analysis (NMA), integrating direct and indirect comparisons from randomised controlled trials (RCTs) to rank psychological treatments for schizophrenia according to their efficacy, acceptability and tolerability. METHODS AND ANALYSIS: We will include all RCTs comparing a psychological treatment aimed at positive symptoms of schizophrenia with another psychological intervention or with a no treatment condition (waiting-list and treatment as usual)...
March 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29490922/living-network-meta-analysis-compared-with-pairwise-meta-analysis-in-comparative-effectiveness-research-empirical-study
#4
REVIEW
Adriani Nikolakopoulou, Dimitris Mavridis, Toshi A Furukawa, Andrea Cipriani, Andrea C Tricco, Sharon E Straus, George C M Siontis, Matthias Egger, Georgia Salanti
OBJECTIVE: To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) ("living" network meta-analysis) provides strong evidence against the null hypothesis in comparative effectiveness of medical interventions earlier than the updating of conventional, pairwise meta-analysis. DESIGN: Empirical study of the accumulating evidence about the comparative effectiveness of clinical interventions. DATA SOURCES: Database of network meta-analyses of RCTs identified through searches of Medline, Embase, and the Cochrane Database of Systematic Reviews until 14 April 2015...
February 28, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29477251/comparative-efficacy-and-acceptability-of-21-antidepressant-drugs-for-the-acute-treatment-of-adults-with-major-depressive-disorder-a-systematic-review-and-network-meta-analysis
#5
Andrea Cipriani, Toshi A Furukawa, Georgia Salanti, Anna Chaimani, Lauren Z Atkinson, Yusuke Ogawa, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Julian P T Higgins, Matthias Egger, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
BACKGROUND: Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of inadequate resources, antidepressants are used more frequently than psychological interventions. Prescription of these agents should be informed by the best available evidence. Therefore, we aimed to update and expand our previous work to compare and rank antidepressants for the acute treatment of adults with unipolar major depressive disorder...
February 20, 2018: Lancet
https://www.readbyqxmd.com/read/29467161/outcomes-of-non-invasive-diagnostic-modalities-for-the-detection-of-coronary-artery-disease-network-meta-analysis-of-diagnostic-randomised-controlled-trials
#6
REVIEW
George Cm Siontis, Dimitris Mavridis, John P Greenwood, Bernadette Coles, Adriani Nikolakopoulou, Peter Jüni, Georgia Salanti, Stephan Windecker
OBJECTIVE: To evaluate differences in downstream testing, coronary revascularisation, and clinical outcomes following non-invasive diagnostic modalities used to detect coronary artery disease. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medline, Medline in process, Embase, Cochrane Library for clinical trials, PubMed, Web of Science, SCOPUS, WHO International Clinical Trials Registry Platform, and Clinicaltrials.gov...
February 21, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29399414/virus-like-particle-display-of-her2-induces-potent-anti-cancer-responses
#7
Arianna Palladini, Susan Thrane, Christoph M Janitzek, Jessica Pihl, Stine B Clemmensen, Willem Adriaan de Jongh, Thomas M Clausen, Giordano Nicoletti, Lorena Landuzzi, Manuel L Penichet, Tania Balboni, Marianna L Ianzano, Veronica Giusti, Thor G Theander, Morten A Nielsen, Ali Salanti, Pier-Luigi Lollini, Patrizia Nanni, Adam F Sander
Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20-30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side effects and development of resistance. Active vaccination may represent a safer, more effective and cheaper alternative, although the induction of strong and durable autoantibody responses is hampered by immune-tolerogenic mechanisms. Using a novel virus-like particle (VLP) based vaccine platform we show that directional, high-density display of human HER2 on the surface of VLPs, allows induction of therapeutically potent anti-HER2 autoantibody responses...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29378797/clinical-outcomes-of-submicroscopic-infections-and-correlates-of-protection-of-var2csa-antibodies-in-a-longitudinal-study-of-pregnant-women-in-colombia
#8
Kenneth Gavina, Sedami Gnidehou, Eliana Arango, Chloe Hamel-Martineau, Catherine Mitran, Olga Agudelo, Carolina Lopez, Aisha Karidio, Shanna Banman, Jaime Carmona-Fonseca, Ali Salanti, Nicaise Tuikue Ndam, Michael Hawkes, Amanda Maestre, Stephanie K Yanow
Malaria in pregnancy can cause serious adverse outcomes for the mother and the fetus. However, little is known about the effects of submicroscopic infections (SMIs) in pregnancy, particularly in areas where Plasmodium falciparum and Plasmodium vivax cocirculate. A cohort of 187 pregnant women living in Puerto Libertador in northwest Colombia was followed longitudinally from recruitment to delivery. Malaria was diagnosed by microscopy, reverse transcription-quantitative PCR (RT-qPCR), and placental histopathology...
April 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29368665/dismantling-cognitive-behaviour-therapy-for-panic-disorder-a-systematic-review-and-component-network-meta-analysis
#9
Alessandro Pompoli, Toshi A Furukawa, Orestis Efthimiou, Hissei Imai, Aran Tajika, Georgia Salanti
Cognitive-behaviour therapy (CBT) for panic disorder may consist of different combinations of several therapeutic components such as relaxation, breathing retraining, cognitive restructuring, interoceptive exposure and/or in vivo exposure. It is therefore important both theoretically and clinically to examine whether specific components of CBT or their combinations are superior to others in the treatment of panic disorder. Component network meta-analysis (NMA) is an extension of standard NMA that can be used to disentangle the treatment effects of different components included in composite interventions...
January 25, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29330216/is-placebo-response-in-antidepressant-trials-rising-or-not-a-reanalysis-of-datasets-to-conclude-this-long-lasting-controversy
#10
REVIEW
Toshi A Furukawa, Andrea Cipriani, Stefan Leucht, Lauren Z Atkinson, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti
It had long been believed that placebo response rates in antidepressant trials have been increasing and that they were responsible for rising numbers of so-called failed antidepressant trials. Two recent systematic reviews examined this issue and reached completely opposite findings. Furukawa and colleagues in a paper published in 2016 found that the placebo response rates are stable since 1991 and the apparent increase up to 2000 was confounded by changes in trial design features. By contrast, Khan and colleagues more recently concluded that placebo response rates had grown steadily in the past 30 years...
February 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29289944/causal-inference-from-experiment-and-observation
#11
Marcel Zwahlen, Geogia Salanti
Results from well-conducted randomised controlled studies should ideally inform on the comparative merits of treatment choices for a health condition. In the absence of this, one attempts to use evidence from the impact of treatment when administered according to decisions of the physicians and the patients (observational evidence). Naïve comparisons between treatment options using observational evidence will lead to biased results. Under certain conditions, however, it is possible to obtain valid estimates of the comparative merits of different treatments from observational data...
February 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29233084/a-model-for-meta-analysis-of-correlated-binary-outcomes-the-case-of-split-body-interventions
#12
Orestis Efthimiou, Dimitris Mavridis, Adriani Nikolakopoulou, Gerta Rücker, Sven Trelle, Matthias Egger, Georgia Salanti
In several areas of clinical research, it is common for trials to assign different sites of the participants' bodies to different interventions. For example, a randomized controlled trial comparing surgical techniques for correcting myopia may randomize each eye of a participant to a different operation. Under such bilateral ('split-body') interventions, the observations from each participant are correlated. It is challenging to account for these correlations at the meta-analysis level, especially when the outcome is rare...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29089635/a-versatile-high-through-put-bead-based-phagocytosis-assay-for-plasmodium-falciparum
#13
Yukie M Lloyd, Elise P Ngati, Ali Salanti, Rose G F Leke, Diane W Taylor
Antibody-mediated phagocytosis is an important immune effector mechanism against Plasmodium falciparum-infected erythrocytes (IE); however, current phagocytosis assays use IE collected from infected individuals or from in vitro cultures of P. falciparum, making them prone to high variation. A simple, high-throughput flow cytometric assay was developed that uses THP-1 cells and fluorescent beads covalently-coupled with the malarial antigen VAR2CSA. The assay is highly repeatable, provides both the overall percent phagocytosis and semi-quantitates the number of antigen-coupled beads internalized...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29064911/efficacy-of-antidepressants-over-placebo-is-similar-in-two-armed-versus-three-armed-or-more-armed-randomized-placebo-controlled-trials
#14
Yusuke Ogawa, Toshi A Furukawa, Nozomi Takeshima, Yu Hayasaka, Lauren Z Atkinson, Shiro Tanaka, Andrea Cipriani, Georgia Salanti
Previous studies have reported that effect sizes of antidepressants were larger in two-armed than in three-armed or more-armed (multiarmed) randomized trials, where the probability of being allocated to placebo is lower. However, these studies have not taken into account the publication bias, differences among antidepressants, or covariance in multiarmed studies, or examined sponsorship bias. We searched published and unpublished randomized-controlled trials that compared placebo with 21 antidepressants for the acute treatment of major depression in adults...
October 23, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29062332/a-var2csa-csp-conjugate-capable-of-inducing-dual-specificity-antibody-responses
#15
Matondo Sungwa, Thrane Susan, Janitzek Christoph Mikkel, Kavishe Reginald Adolph, Mwakalinga Steven Boniface, Theander Thor Grundtvig, Salanti Ali, Nielsen Morten Agertoug, Sander Adam Frederik
BACKGROUND: Vaccine antigens targeting specific P. falciparum parasite stages are under pre-clinical and clinical development. It seems plausible that vaccine with multiple specificities will offer higher protection. With this hypothesis, we exploited the Spy-Tag/SpyCatcher conjugation system to make a, post expression, dual antigen conjugate vaccine, comprising two clinically tested antigen candidates (CSP and VAR2CSA). METHODS: The DBL1x-DBL2x-ID2a region of VAR2CSA was genetically fused with SpyTag at N-terminus...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29029247/plasmodium-falciparum-infection-early-in-pregnancy-has-profound-consequences-for-fetal-growth
#16
Christentze Schmiegelow, Sungwa Matondo, Daniel T R Minja, Mafalda Resende, Caroline Pehrson, Birgitte Bruun Nielsen, Raimos Olomi, Morten A Nielsen, Philippe Deloron, Ali Salanti, John Lusingu, Thor G Theander
Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95% confidence interval {CI}, 26-188]; P = ...
December 19, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28962616/statistical-prediction-of-immunity-to-placental-malaria-based-on-multi-assay-antibody-data-for-malarial-antigens
#17
Chathura Siriwardhana, Rui Fang, Ali Salanti, Rose G F Leke, Naveen Bobbili, Diane Wallace Taylor, John J Chen
BACKGROUND: Plasmodium falciparum infections are especially severe in pregnant women because infected erythrocytes (IE) express VAR2CSA, a ligand that binds to placental trophoblasts, causing IE to accumulate in the placenta. Resulting inflammation and pathology increases a woman's risk of anemia, miscarriage, premature deliveries, and having low birthweight (LBW) babies. Antibodies (Ab) to VAR2CSA reduce placental parasitaemia and improve pregnancy outcomes. Currently, no single assay is able to predict if a woman has adequate immunity to prevent placental malaria (PM)...
September 29, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28912004/living-systematic-reviews-3-statistical-methods-for-updating-meta-analyses
#18
Mark Simmonds, Georgia Salanti, Joanne McKenzie, Julian Elliott
A living systematic review (LSR) should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified. If the aim of the review is solely to present the best current evidence standard meta-analysis may be sufficient, provided reviewers are aware that results may change at later updates. If the review is used in a decision-making context, more caution may be needed. When using standard meta-analysis methods, the chance of incorrectly concluding that any updated meta-analysis is statistically significant when there is no effect (the type I error) increases rapidly as more updates are performed...
November 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28912002/living-systematic-review-1-introduction-the-why-what-when-and-how
#19
Julian H Elliott, Anneliese Synnot, Tari Turner, Mark Simmonds, Elie A Akl, Steve McDonald, Georgia Salanti, Joerg Meerpohl, Harriet MacLehose, John Hilton, David Tovey, Ian Shemilt, James Thomas
Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in review currency, accuracy, and utility. We are developing a novel approach to systematic review updating termed "Living systematic review" (LSR): systematic reviews that are continually updated, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields where research evidence is emerging rapidly, current evidence is uncertain, and new research may change policy or practice decisions...
November 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28903924/multivariate-and-network-meta-analysis-of-multiple-outcomes-and-multiple-treatments-rationale-concepts-and-examples
#20
Richard D Riley, Dan Jackson, Georgia Salanti, Danielle L Burke, Malcolm Price, Jamie Kirkham, Ian R White
No abstract text is available yet for this article.
September 13, 2017: BMJ: British Medical Journal
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