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https://www.readbyqxmd.com/read/28436290/topography-of-protein-kinase-c-%C3%AE-ii-in-benign-and-malignant-melanocytic-lesions
#1
Konstanin Krasagakis, Eleftheria Tsentelierou, Gregory Chlouverakis, Efstathios N Stathopoulos
BACKGROUND: Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. OBJECTIVE: To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. METHODS: Expression of PKC-βII was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry...
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28436025/melanoma-in%C3%A2-situ-of-lentigo-maligna-type-in-a-young-woman
#2
Matthew F Helm, Michael J Bax, David J Augenblick, Catherine G Chung
No abstract text is available yet for this article.
April 23, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28430732/noninvasive-rcm-for-differentiation-of-melanotic-macules-from-melanocytic-lesions-blinded-evaluation-of-a-series-of-42-pigmented-macules
#3
Martin Laimer, Edith Arzberger, Clara-Anna Kirchner, Christine Prodinger, Rainer Hofmann-Wellenhof, Verena Ahlgrimm-Siess
BACKGROUND: Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination. OBJECTIVE: To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions. PATIENTS AND METHODS: Reflectance confocal microscopy images of 42 pigmented macules on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together...
April 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28403068/malignant-melanoma-in-african-americans-a-population-based-clinical-outcomes-study-involving-1106-african-american-patients-from-the-surveillance-epidemiology-and-end-result-seer-database-1988-2011
#4
Krishnaraj Mahendraraj, Komal Sidhu, Christine S M Lau, Georgia J McRoy, Ronald S Chamberlain, Franz O Smith
Malignant melanoma accounts for 75% of all skin cancer deaths and is potentially curable if identified early. Although melanoma is rare in African-Americans (AA), it is associated with a worse prognosis than in Caucasians. This study examines the demographic, pathologic, and clinical factors impacting AA melanoma outcomes.Data for 1106 AA and 212,721 Caucasian cutaneous melanoma patients were abstracted from the Surveillance, Epidemiology, and End Result (SEER) database (1988-2011). Data were grouped on the basis of histological subtypes: "Superficial Spreading" (SS), "Nodular" (NM), "Lentigo Maligna" (LM), "Acral Lentiginous" (AL), and "Not otherwise specified" (NOS)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28381809/coumestrol-down-regulates-melanin-production-in-melan-a-murine-melanocytes-through-degradation-of-tyrosinase
#5
Jeong Ah Hwang, Nok Hyun Park, Yong Joo Na, Hae Kwang Lee, John Hwan Lee, Yong Jin Kim, Chang Seok Lee
Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28369728/imiquimod-treatment-for-lentigo-maligna-limit-1-trial
#6
N G Maher, P Guitera
We read with interest the methods and results of the LIMIT-1 trial regarding primary imiquimod treatment for lentigo maligna (LM) in the journal.(1) We applaud the authors for using histopathology from a resective specimen as the reference standard. This article is protected by copyright. All rights reserved.
March 29, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28348944/tumoral-melanosis-associated-with-pembrolizumab-treated-metastatic-melanoma
#7
Omar Bari, Philip R Cohen
Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. An 81-year-old man with metastatic melanoma treated with pembrolizumab who developed tumoral melanosis at previous sites of metastases is described. The PubMed database was searched with the key words: antibody, immunotherapy, melanoma, melanosis, metastasis, pembrolizumab, and tumoral...
February 13, 2017: Curēus
https://www.readbyqxmd.com/read/28346250/reconstruction-of-combined-upper-and-lower-eyelid-defects-in-a-patient-with-lentigo-maligna
#8
Ana Martínez-Palmer, Marta Calsina-Prat, Nerea Ormaechea, Agustí Toll
No abstract text is available yet for this article.
March 23, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28341252/correlation-between-digital-epiluminescence-microscopy-parameters-and-histopathological-changes-in-lentigo-maligna-and-solar-lentigo-a-dermoscopic-index-for-the-diagnosis-of-lentigo-maligna
#9
Giorgio Annessi, Riccardo Bono, Damiano Abeni
BACKGROUND: The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult. OBJECTIVE: Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new model of LM dermoscopic progression based on a study of DELM-histopathological correlation. METHODS: A total of 167 consecutive doubtful pigmented lesions of the head (105 LM and 62 SL/SK) were studied...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28329643/epidemiology-of-lentigo-maligna-and-lentigo-maligna-melanoma-in-the-netherlands-1989-2013
#10
Karin Greveling, Marlies Wakkee, Tamar Nijsten, Renate R Vane den Bos, Loes M Hollestein
Lentigo maligna (LM) is considered a precursor to LM melanoma (LMM). We assessed trends in LM and LMM incidence rates between 1989 and 2013 in the Netherlands, and estimated the risk of a LMM after LM. Data on newly diagnosed LM and LMM were obtained from the Netherlands Cancer Registry and PALGA (Dutch Pathology Database). Age-standardized incidence rates (European standardized rate [ESR]), estimated annual percentage changes (EAPC), and the cumulative incidence of LMM after LM were calculated. Between 1989-2013, 10,545 patients were diagnosed with a primary LM and 2,898 with a primary LMM in the Netherlands...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328709/the-clinical-and-histological-effect-of-a-low-fluence-q-switched-1-064-nm-neodymium-yttrium-aluminum-garnet-laser-for-the-treatment-of-melasma-and-solar-lentigo-in-asians-prospective-randomized-and-split-face-comparative-study
#11
Chikako Kaminaka, Fukumi Furukawa, Yuki Yamamoto
BACKGROUND: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians. OBJECTIVE: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo. MATERIALS AND METHODS: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28296789/locally-recurrent-lentigo-maligna-and-lentigo-maligna-melanoma-characteristics-and-time-to-recurrence-after-surgery
#12
Karen L Connolly, Brian P Hibler, Erica H Lee, Anthony M Rossi, Klaus J Busam, Kishwer S Nehal
BACKGROUND: Various studies have reported local recurrence (LR) rates after surgical treatment of lentigo maligna (LM) and lentigo maligna melanoma (LMM). However, the time to LR of LM/LMM is not currently known, as few studies report time to LR and have long-term follow-up. OBJECTIVE: To define time to LR in LM/LMM after surgical treatment, and to describe features of observed LR. MATERIALS AND METHODS: Retrospective single-center study of consecutive patients presenting with locally recurrent LM/LMM...
March 14, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28295169/characteristic-features-of-cutaneous-melanoma-in-a-dermatology-referral-centre-in-tehran-iran
#13
Kambiz Kamyab, Sheyda Kazemi, Pourya Azimi, Arghavan Azizpour, Narges Ghandi, Elham Pirooz, Pedram Noormohammadpour, Mostafa Mirshams-Shahshahani, Maryam Daneshpazhooh
BACKGROUND/OBJECTIVES: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran. METHODS: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Clinical data included age and gender of the patients at the time of diagnosis, tumour location and tumour size. Histological characteristics included Breslow thickness, Clark level and subtype of tumour...
March 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28247492/lentigo-maligna-successfully-treated-with-combination-therapy-of-topical-tazarotene-and-imiquimod
#14
S Menzies, M Mc Menamin, R Barry
No abstract text is available yet for this article.
March 1, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28224656/diagnosis-and-management-of-lentigo-maligna-an-observational-study-comparing-2005-with-2014-data-in-one-institution
#15
S Hawkey, A Affleck
The incidence, clinical characteristics and management of lentigo maligna (LM) were assessed in a university hospital setting in 2005 and 2014. Multiple clinical variables were compared, and 28 and 43 cases, respectively were identified during the two time periods. The most common site of presentation was the cheek (50% vs. 44%), and an accurate clinical diagnosis of LM was made in 60% vs. 72%) of cases. Most of the patients received surgical treatment (75% in 2005 vs. 97% in 2014), with 47% and 33% of excisions, respectively, remaining involved at the peripheral surgical margin...
February 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28218469/diagnostic-accuracy-of-reflectance-confocal-microscopy-using-vivascope-for-detecting-and-monitoring-skin-lesions-a-systematic-review
#16
S J Edwards, G Osei-Assibey, R Patalay, V Wakefield, C Karner
BACKGROUND: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy. AIM: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28099598/dermatoscopy-guided-therapy-of-pigmented-basal-cell-carcinoma-with-imiquimod
#17
Husein Husein-ElAhmed, Maria Antonia Fernandez-Pugnaire
BACKGROUND: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod. OBJECTIVE: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. METHOD: The authors designed a prospective study...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28062074/-ink-spot-lentigo
#18
M Berger, L Thomas, S Dalle
No abstract text is available yet for this article.
March 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27987308/a-systematic-review-on-the-role-of-imiquimod-in-lentigo-maligna-and-lentigo-maligna-melanoma-need-for-standardization-of-treatment-schedule-and-outcome-measures
#19
REVIEW
D Tio, J van der Woude, C A C Prinsen, E P Jansma, R Hoekzema, C van Montfrans
Lentigo maligna (LM) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma (LMM). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Articles were included if they described histologically proven LM treated with imiquimod 5% monotherapy or combined with another topical therapy. Analysed outcomes were clinical and histological clearance, recurrence rates and number of LMM...
April 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27967258/vaginal-lentigo-in-a-postmenopausal-patient-report-of-a-unique-entity
#20
Simona Stolnicu, Cosmin Moldovan, Anca Chiriac, Doina Ivan
No abstract text is available yet for this article.
December 14, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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