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https://www.readbyqxmd.com/read/29642438/sesamol-inhibited-melanogenesis-by-regulating-melanin-related-signal-transduction-in-b16f10-cells
#1
Po-Yuan Wu, Ya-Jhen You, Yi-Jung Liu, Chien-Wei Hou, Chin-Sheng Wu, Kuo-Ching Wen, Chien-Yih Lin, Hsiu-Mei Chiang
Melanin is synthesized through a series of interactions catalyzed by melanogenic enzymes such as tyrosinase, dopachrome tautomerase (tyrosinase-related protein-2; TRP-2), and tyrosinase-related protein-1 (TRP-1). Tyrosinase plays a key role in catalysing the initial and limiting steps of melanogenesis. The melanin that results from melanogenesis has the protective effect of absorbing ultraviolet radiation. However, overproduction of melanin, in addition to altering the appearance of skin, may lead to skin disorders such as melasma, solar lentigo, and postinflammatory hyperpigmentation...
April 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29620004/a-new-dermoscopic-algorithm-for-the-differential-diagnosis-of-facial-lentigo-maligna-and-pigmented-actinic-keratosis
#2
Tamara Micantonio, Luca Neri, Caterina Longo, Simone Grassi, Alessandro Di Stefani, Ambra Antonini, Valeria Coco, Maria Concetta Fargnoli, Giuseppe Argenziano, Ketty Peris
The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. In the first part of the study, 61 cases of LM and 74 PAK were examined and a parsimonious algorithm was elaborated using stepwise discriminant analysis...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29608215/prospective-study-of-removing-solar-lentigines-in-asians-using-a-novel-dual-wavelength-and-dual-pulse-width-picosecond-laser
#3
Kei Negishi, Hirotaka Akita, Yukiko Matsunaga
OBJECTIVES: Quality-switched (QS) lasers are known to be an effective treatment for removing solar lentigines, however, high incidence of post-inflammatory hyperpigmentation (PIH) is a concern in darker skin types. The objective of this study was to evaluate the efficacy and safety of a dual-wavelength and dual-pulse width picosecond Nd:YAG laser for removing solar lentigines in Asians. METHODS: This was a prospective, IRB-approved study. Twenty cases with solar lentigines on the face were enrolled for treatment and evaluated at 1- and 3-month after the final treatment...
April 2, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29573292/in-vivo-reflectance-confocal-microscopy-combined-with-the-spaghetti-technique-for-the-identification-of-surgical-margins-of-lentigo-maligna-experience-in-70-patients
#4
Emmanuelle Couty, Linda Tognetti, Bruno Labeille, Catherine Douchet, Cyril Habougit, Caroline Couzan, Anne Catherine Biron-Schneider, Frédéric Cambazard, Virginie Prade, Pietro Rubegni, Elisa Cinotti, J L Perrot
Lentigo maligna (LM) and lentigo maligna melanoma (LMM) account for 10% of all melanomas and are mainly located on head and neck areas.1-4 Complete surgical excision is the recommended treatment. However, this treatment is often challenging because of LM/LMM location in the face and the difficulty in the identification of its surgical margins1-5 . Local recurrence of LM/LMM still represents a major concern with recurrence rates after conventional surgical excision of 8 to 20% of cases, up to 47% in absence of Mohs micrographic surgery (MMS)...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29543619/treatment-for-lentigo-maligna-of-the-head-and-neck-survey-of-practices-in-ontario-canada
#5
Annie Liu, Alexis Botkin, Christian Murray, David Goldstein, Stefan O P Hofer, Nowell Solish, Jessica Kitchen, An-Wen Chan
BACKGROUND: Lentigo maligna is an in situ form of cutaneous melanoma that commonly arises on the head and neck. Various surgical and nonsurgical treatment options are available but no randomized trials exist to guide practice. OBJECTIVE: To determine the current treatment practices for lentigo maligna of the head and neck in Ontario, Canada. MATERIALS AND METHODS: Cross-sectional survey of dermatologists, plastic surgeons, and head and neck surgeons...
March 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29505310/intradermal-tranexamic-acid-injections-to-prevent-post-inflammatory-hyperpigmentation-after-solar-lentigo-removal-with-a-q-switched-532-nm-nd-yag-laser
#6
Punyaphat Sirithanabadeekul, Rattima Srieakpanit
INTRODUCTION: Post-inflammatory hyperpigmentation (PIH) after solar lentigo removal using a Q-switched (QS) 532-nm Nd:YAG laser is a cause for concern. This study aimed to evaluate the efficacy and safety of intradermal injections of tranexamic acid (TA) at reducing the risk of PIH after QS 532-nm Nd:YAG laser treatment of solar lentigines. METHODS: Twenty-five patients with 50 solar lentigines on forearms underwent QS 532-nm Nd:YAG laser treatment. Then, TA (50 mg/mL) was injected randomly into one lesion and 0...
March 5, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29453870/comparison-of-melanocyte-density-counts-in-topical-imiquimod-treated-skin-surrounding-lentigo-maligna-vs-control-biopsy-specimens
#7
Shadai Flores, Nathan J Luby, Glen M Bowen
No abstract text is available yet for this article.
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29446160/protection-against-summer-solar-lentigo-over-pigmentation-with-a-spf30-daily-cream
#8
G Josse, J Le Digabel, E Questel
BACKGROUND/PURPOSE: The aim of this study was to measure lentigines' pigmentation over a long period of time and evaluate if summer over-pigmentation can be avoided by the use a SPF30 day skin cream. METHODS: Seventeen healthy female volunteers aged 50 and over and presenting lentigines participated in the study from spring to summer. Throughout the study, all subjects applied a SPF30 daily skin cream to only one hand. Color measurements of the target lesions were performed with a chromameter and with a color-calibrated camera...
February 15, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29430695/immunocryosurgery-as-monotherapy-for-lentigo-maligna-or-combined-with-surgical-excision-for-lentigo-maligna-melanoma
#9
Clara Matas-Nadal, Xavier Sòria, María R García-de-la-Fuente, Valentín Huerva, Eugenia Ortega, Felip Vilardell, Sònia Gatius, Josep M Casanova, Rosa M Martí
The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Three patients with LM or LMM not amenable to complete surgical excision were selected. LMM patients underwent limited surgical resection of the invasive area...
February 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29428356/classification-of-the-clinical-images-for-benign-and-malignant-cutaneous-tumors-using-a-deep-learning-algorithm
#10
Seung Seog Han, Myoung Shin Kim, Woohyung Lim, Gyeong Hun Park, Ilwoo Park, Sung Eun Chang
We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total)...
February 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29419913/variation-in-the-diagnosis-and-clinical-management-of-lentigo-maligna-across-europe-a-survey-study-among-eadv-members
#11
D Tio, C A C Prinsen, B Dréno, R Hoekzema, M Augustin, C van Montfrans
BACKGROUND: Lentigo maligna (LM), a form of melanoma in situ, is treated to prevent progression to lentigo maligna melanoma (LMM). Surgical treatment is the gold standard. However, treatment guidelines are based on expert opinion and comparative studies are lacking. OBJECTIVE: The objective of this study is to assess the diagnostic methods and clinical management of LM patients among European dermatologists and residents. METHODS: A survey consisting of 29 questions about diagnostic methods and treatment options used for LM patients was sent to 3308 members of the European association of Dermatologists and Venereologists (EADV)...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29388348/benign-and-malignant-collision-tumors-of-melanocytic-skin-lesions-with-hemangioma-dermoscopic-and-reflectance-confocal-microscopy-features
#12
L Tognetti, E Cinotti, J L Perrot, M Campoli, M Fimiani, P Rubegni
BACKGROUND: Though the combination/collision of nevi or lentigo simplex and hemangiomas is frequent, the malignant collision tumor melanoma-hemangioma is exceptional and can sometime clinically simulate a benign collision. To date, a series of collision tumors of hemangiomas associated with either benign or malignant melanocytic skin lesions (MSL) has yet to be studied by non-invasive imaging and clinico-pathologic correlates. METHODS: We present 10 cases of patients with collision tumors of hemangioma with different MSL including: 2 in situ lentigo-maligna melanoma, 1 invasive melanoma, 5 melanocytic nevi, and 2 lentigo simplex...
January 31, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29385866/lentigo-vaginae-vaginal-melanosis
#13
Luca Roncati
No abstract text is available yet for this article.
January 31, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29377079/incidence-of-diseases-primarily-affecting-the-skin-by-age-group-population-based-epidemiologic-study-in-olmsted-county-minnesota-and-comparison-with-age-specific-incidence-rates-worldwide
#14
REVIEW
Laurel L Wessman, Louise K Andersen, Mark D P Davis
Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature...
January 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29341263/dermoscopy-versus-reflectance-confocal-microscopy-for-the-diagnosis-of-lentigo-maligna
#15
E Cinotti, B Labeille, S Debarbieux, C Carrera, F Lacarrubba, A M Witkowski, E Moscarella, E Arzberger, H Kittler, P Bahadoran, S Gonzalez, P Guitera, M Agozzino, F Farnetani, R Hofmann-Wellenhof, M Ardigò, P Rubegni, L Tognetti, J Łudzik, I Zalaudek, G Argenziano, C Longo, S Ribero, J Malvehy, G Pellacani, F Cambazard, J L Perrot
BACKGROUND: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques. OBJECTIVE: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. METHODS: 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic and RCM examination were compared...
January 17, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29327697/an-unusual-early-onset-of-lentigo-maligna-in-the-fourth-decade-of-life
#16
Eftychia Platsidaki, Nikolaos Kostopoulos, Kanellos Gesakis, Dorothea Polydorou, Efthymia Agiasofitou
No abstract text is available yet for this article.
January 5, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29314288/the-limitations-of-dermoscopy-false-positive-and-false-negative-tumours
#17
REVIEW
V Papageorgiou, Z Apalla, E Sotiriou, C Papageorgiou, E Lazaridou, S Vakirlis, D Ioannides, A Lallas
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. False-negative diagnosis is much more dangerous, as it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false-negative tumours...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29313931/characterization-of-actinic-lentigos-using-a-multifaceted-approach
#18
A K Langton
No abstract text is available yet for this article.
December 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29311040/prevalence-and-risk-factors-of-actinic-keratosis-in-patients-attending-italian-dermatology-clinics
#19
Maria Concetta Fargnoli, Gianfranco Altomare, Elisa Benati, Francesco Borgia, Paolo Broganelli, Anna Carbone, Sergio Chimenti, Sergio Donato, Giampiero Girolomoni, Giuseppe Micali, Erica Moggio, Aurora Parodi, Stefano Piaserico, Giuseppe Pistone, Concetta Potenza, Mario Puviani, Margherita Raucci, Sabina Vaccari, Stefano Veglio, Andrea Zanca, Ketty Peris
Actinic keratosis (AK) is a common keratinocyte intra-epidermal neoplasia. To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics. This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented...
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29296480/wavelet-based-statistical-classification-of-skin-images-acquired-with-reflectance-confocal-microscopy
#20
Abdelghafour Halimi, Hadj Batatia, Jimmy Le Digabel, Gwendal Josse, Jean Yves Tourneret
Detecting skin lentigo in reflectance confocal microscopy images is an important and challenging problem. This imaging modality has not yet been widely investigated for this problem and there are a few automatic processing techniques. They are mostly based on machine learning approaches and rely on numerous classical image features that lead to high computational costs given the very large resolution of these images. This paper presents a detection method with very low computational complexity that is able to identify the skin depth at which the lentigo can be detected...
December 1, 2017: Biomedical Optics Express
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