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https://www.readbyqxmd.com/read/28105693/epigenetic-regulation-of-wnt-%C3%AE-catenin-signal-associated-genes-in-gastric-neoplasia-of-the-fundic-gland-chief-cell-predominant-type
#1
Takashi Murakami, Hiroyuki Mitomi, Takashi Yao, Tsuyoshi Saito, Tomoyoshi Shibuya, Sumio Watanabe
Gastric neoplasia of the fundic gland (chief cell-predominant) type (GNCCP) is a rare variant of gastric tumor. This tumor is associated with activation of the Wnt/β-catenin signaling pathway; however, the mechanisms underlying this activation remain unknown. To elucidate potential roles of Wnt/β-catenin signal-associated gene methylation in GNCCP, we performed β-catenin immunostaining and methylation-specific polymerase chain reaction (PCR) for their associated genes, including SFRPs, APC, AXIN2, and MCC, in 26 GNCCPs [i...
January 20, 2017: Pathology International
https://www.readbyqxmd.com/read/28103753/anchor-balloon-technique
#2
Kei Shibuya, Norimasa Koike, Jun Mohara, Toru Takahashi, Yoshito Tsushima
Occlusion of an internal iliac artery or its branches is sometimes required prior to abdominal endovascular aneurysm repair. The Amplatzer vascular plug (AVP) is a useful device for this purpose, but it requires a large lumen catheter or guiding sheath to place it in the intended artery. We propose an anchor balloon technique for advancing this guiding sheath/catheter through a tortuous or angulated iliac artery for AVP placement.
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28091361/responses-of-plasma-glucose-metabolism-to-exogenous-insulin-infusion-in-sheep-fed-forage-herb-plantain-and-exposed-to-heat
#3
M Al-Mamun, K Shibuya, M Kajita, Y Tamura, H Sano
The use of herbal plants as traditional medicines has a century long history. Plantain (Plantago lanceolata L.) is a perennial herb containing bioactive components with free radical scavenging activities. An isotope dilution technique using [U-13C]glucose was conducted to determine the effect of plantain on the responses of plasma glucose metabolism to exogenous insulin infusion in sheep. Six crossbred sheep (three wethers and three ewes; mean initial BW=40±2 kg) were fed either a mixed hay of orchardgrass (Dactylis glomerata) and reed canarygrass (Phalaris arundinacea) (MH-diet) or mixed hay and fresh plantain (1 : 1 ratio, dry matter basis, PL-diet) and exposed to a thermoneutral (TN, 20°C; 70% relative humidity (RH)) environment or a heat exposure (HE, 30°C; 70% RH) for 5 days using a crossover design for two 23-day periods...
January 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28079151/discovery-and-mechanistic-characterization-of-selective-inhibitors-of-h2s-producing-enzyme-3-mercaptopyruvate-sulfurtransferase-3mst-targeting-active-site-cysteine-persulfide
#4
Kenjiro Hanaoka, Kiyoshi Sasakura, Yusuke Suwanai, Sachiko Toma-Fukai, Kazuhito Shimamoto, Yoko Takano, Norihiro Shibuya, Takuya Terai, Toru Komatsu, Tasuku Ueno, Yuki Ogasawara, Yukihiro Tsuchiya, Yasuo Watanabe, Hideo Kimura, Chao Wang, Masanobu Uchiyama, Hirotatsu Kojima, Takayoshi Okabe, Yasuteru Urano, Toshiyuki Shimizu, Tetsuo Nagano
Very recent studies indicate that sulfur atoms with oxidation state 0 or -1, called sulfane sulfurs, are the actual mediators of some physiological processes previously considered to be regulated by hydrogen sulfide (H2S). 3-Mercaptopyruvate sulfurtransferase (3MST), one of three H2S-producing enzymes, was also recently shown to produce sulfane sulfur (H2Sn). Here, we report the discovery of several potent 3MST inhibitors by means of high-throughput screening (HTS) of a large chemical library (174,118 compounds) with our H2S-selective fluorescent probe, HSip-1...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072584/verification-of-respiratory-gated-radiotherapy-with-new-real-time-tumour-tracking-radiotherapy-system-using-cine-epid-images-and-a-log-file
#5
Takehiro Shiinoki, Hideki Hanazawa, Yuki Yuasa, Koya Fujimoto, Takuya Uehara, Keiko Shibuya
<u>Purposes:</u> A combined system comprising the TrueBeam linear accelerator and a new real-time tumour-tracking radiotherapy system, SyncTraX, was installed at our institution. The objectives of this study are to develop a method for the verification of respiratory-gated radiotherapy with SyncTraX using cine electronic portal image device (EPID) images and a log file and to verify this treatment in clinical cases. <u>Methods and Materials:</u> Respiratory-gated radiotherapy was performed using TrueBeam and the SyncTraX system...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28069692/genes-involved-in-development-and-differentiation-are-commonly-methylated-in-cancers-derived-from-multiple-organs-a-single-institutional-methylome-analysis-using-1007-tissue-specimens
#6
Kentaro Ohara, Eri Arai, Yoriko Takahashi, Nanako Ito, Ayako Shibuya, Koji Tsuta, Ryoji Kushima, Hitoshi Tsuda, Hidenori Ojima, Hiroyuki Fujimoto, Shun-Ichi Watanabe, Hitoshi Katai, Takayuki Kinoshita, Tatsuhiro Shibata, Takashi Kohno, Yae Kanai
The aim of this study was to clarify the significance of DNA methylation alterations shared by cancers derived from multiple organs. We analyzed single-institutional methylome data by single-CpG-resolution Infinium assay for 1,007 samples of non-cancerous tissue (N) and corresponding cancerous tissue (T) obtained from lung, stomach, kidney, breast and liver. Principal component analysis revealed that N samples of each organ showed distinct DNA methylation profiles, DNA methylation profiles of N samples of each organ being inherited by the corresponding T samples and DNA methylation profiles of T samples being more similar to those of N samples in the same organ than those of T samples in other organs...
January 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28068714/video-comment-on-shibuya-et-al
#7
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Endoscopy
https://www.readbyqxmd.com/read/28057427/fiducial-marker-matching-versus-vertebral-body-matching-dosimetric-impact-of-patient-positioning-in-carbon-ion-radiotherapy-for-primary-hepatic-cancer
#8
Satoshi Abe, Yoshiki Kubota, Kei Shibuya, Yoshinari Koyama, Takanori Abe, Tatsuya Ohno, Takashi Nakano
PURPOSE: The aim of this study was to compare the dose-volume parameters of fiducial marker matching (MM) with vertebral body matching (VM) in patient positioning for carbon ion radiotherapy for primary hepatic cancer. MATERIALS AND METHODS: Twenty patients with primary hepatic cancer were retrospectively studied to assess changes in reproducibility of tumor position and dose distribution on two CT scans. One was for treatment planning and another was for dose confirmation, acquired the day before the first treatment day...
January 2, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28057036/clinical-outcomes-of-stage-i-and-iia-non-small-cell-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy-using-a-real-time-tumor-tracking-radiotherapy-system
#9
Norio Katoh, Itaru Soda, Hiroyasu Tamamura, Shotaro Takahashi, Yusuke Uchinami, Hiromichi Ishiyama, Kiyotaka Ota, Tetsuya Inoue, Rikiya Onimaru, Keiko Shibuya, Kazushige Hayakawa, Hiroki Shirato
PURPOSE: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. MATERIALS AND METHODS: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner...
January 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28054160/antithrombotic-protein-filter-composed-of-hybrid-tissue-fabric-material-has-a-long-lifetime
#10
Yusuke Inoue, Tomoyuki Yokota, Tsuyoshi Sekitani, Akiko Kaneko, Taeseong Woo, Shingo Kobayashi, Tomokazu Shibuya, Masaru Tanaka, Hiroyuki Kosukegawa, Itsuro Saito, Takashi Isoyama, Yusuke Abe, Tomoyuki Yambe, Takao Someya, Masaki Sekino
There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric material sheets. The hybrid materials comprised biological tissue grown on the fabric. The materials were extracted from the rat's body, approximately 100 days post-implantation. The tissues were decellularized to prevent immunological rejection...
January 4, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28047856/su-f-t-500-the-effectiveness-of-a-patient-specific-bolus-made-by-using-three-dimensional-printing-technique-in-photon-radiotherapy
#11
K Fujimoto, T Shiinoki, Y Yuasa, H Hanazawa, K Shibuya
PURPOSE: A commercially available bolus (commercial-bolus) would not completely contact with the irregular shape of a patient's skin. The purposes of this study were to customize a patient specific three-dimensional (3D) bolus using a 3D printer (3D-bolus) and to evaluate its clinical feasibility for photon radiotherapy. METHODS: The 3D-bolus was designed using a treatment planning system (TPS) in DICOM-RT format. To print the 3D bolus, the file was converted into stereolithography format...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047558/su-g-jep1-11-feasibility-study-of-markerless-tracking-using-dual-energy-fluoroscopic-images-for-real-time-tumor-tracking-radiotherapy-system
#12
T Shiinoki, A Sawada, T Uehara, Y Yuasa, M Koike, S Kawamura, K Shibuya
PURPOSE: The new real-time tumor-tracking radiotherapy (RTRT) system was installed in our institution. This system consists of two x-ray tubes and color image intensifiers (I.I.s). The fiducial marker which was implanted near the tumor was tracked using color fluoroscopic images. However, the implantation of the fiducial marker is very invasive. Color fluoroscopic images enable to increase the recognition of the tumor. However, these images were not suitable to track the tumor without fiducial marker...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046797/su-g-jep1-08-dual-modality-verification-for-respiratory-gating-using-new-real-time-tumor-tracking-radiotherapy-system
#13
T Shiinoki, S Kawamura, M Koike, Y Yuasa, T Uehara, K Fujimoto, H Hanazawa, K Shibuya
PURPOSE: The respirato ry gating system combined the TrueBeam and a new real-time tumor-tracking radiotherapy system (RTRT) was installed. The RTRT system consists of two x-ray tubes and color image intensifiers. Using fluoroscopic images, the fiducial marker which was implanted near the tumor was tracked and was used as the internal surrogate for respiratory gating. The purposes of this study was to develop the verification technique of the respiratory gating with the new RTRT using cine electronic portal image device images (EPIDs) of TrueBeam and log files of the RTRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032992/cationic-amphiphilic-tris-cyclometalated-iridium-iii-complexes-induce-cancer-cell-death-via-interaction-with-ca-2-calmodulin-complex
#14
Yosuke Hisamatsu, Nozomi Suzuki, Abdullah-Al Masum, Ai Shibuya, Ryo Abe, Akira Sato, Sei-Ichi Tanuma, Shin Aoki
In our previous paper, we reported on the preparation of some cationic amphiphilic Ir complexes (2c, 2d) containing KKGG peptides that induce and detect cell death of Jurkat cells. Mechanistic studies suggest that 2c interacts with anionic molecules and/or membrane receptors on the cell surface to trigger an intracellular Ca(2+) response, resulting in the induction of cell death, accompanied by membrane disruption. We have continued the studies of cell death of Jurkat cells induced by 2c and found that xestospongin C, a selective inhibitor of an inositol 1,4,5-trisphosphate receptor located on the endoplasmic reticulum (ER), reduces the cytotoxicity of 2c, suggesting that 2c triggers the release of Ca(2+) from the ER, leading to an increase in the concentration of cytosolic Ca(2+), thus inducing cell death...
December 29, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28012446/retroperitoneal-liposarcoma-excreting-insulin-like-growth-factor-2-that-induced-severe-hypoglycemia
#15
Takuma Kato, Mikio Sugimoto, Motoki Yamashita, Yasuyuki Miyauchi, Hiromi Hirama, Hiroyuki Tsunemori, Nobufumi Ueda, Hitomi Imachi, Shinsuke Shibuya, Yoshio Kushida, Yoshiyuki Kakehi
Insulin-like growth factor 2 is overexpressed in various cancers, and is associated with a poor prognosis. Also, it is known that insulin-like growth factor 2 is an etiology of non-islet cell tumor hypoglycemia. In this report, we describe a case of unexpected hypoglycemia caused by a dedifferentiated liposarcoma producing insulin-like growth factor 2. A large mass in the retroperitoneum was detected in a 61-year-old man who complained of appetite loss. Despite having no history of diabetes mellitus, hypoglycemia suddenly occurred after admission, but oral glucose therapy was ineffective...
December 24, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28003004/defense-against-pathogens-structural-insights-into-the-mechanism-of-chitin-induced-activation-of-innate-immunity
#16
Flavia Squeglia, Rita Berisio, Naoto Shibuya, Hanae Kaku
Pattern recognition receptors on the plant cell surface mediate the recognition of microbe-associated molecular patterns, in a process which activates downstream immune signaling. These receptors are plasma membrane-localized kinases which need to be autophosphorylated to activate downstream responses. Perception of attacks from fungi occurs through recognition of chitin, a polymer of an N-acetylglucosamine which is a characteristic component of the cell walls of fungi. This process is regulated in Arabidopsis by chitin elicitor receptor kinase CERK1...
December 21, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27998849/comparing-the-vascular-response-in-implantation-of-self-expanding-bare-metal-nitinol-stents-or-paclitaxel-eluting-nitinol-stents-in-superficial-femoral-artery-lesions-a-serial-optical-frequency-domain-imaging-study
#17
Kojiro Miki, Kenichi Fujii, Masahiko Shibuya, Masashi Fukunaga, Takahiro Imanaka, Hiroto Tamaru, Machiko Nishimura, Tetsuo Horimatsu, Yasuhiro Honda, Peter J Fitzgerald, Tohru Masuyama, Masaharu Ishihara
AIMS: This study sought to investigate differences in vascular response between self-expanding bare metal nitinol stents (BMS) and paclitaxel-eluting nitinol stents (PES), in superficial femoral artery (SFA) disease, using optical frequency domain imaging (OFDI). METHODS AND RESULTS: Six months after stent implantation, follow-up quantitative vascular angiography (QVA) and OFDI assessment were scheduled to evaluate vascular response. Volume index (VI) was defined as volume divided by stent length...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27998842/four-year-polymer-biocompatibility-and-vascular-healing-profile-of-a-novel-ultrahigh-molecular-weight-amorphous-plla-bioresorbable-vascular-scaffold-an-oct-study-in-healthy-porcine-coronary-arteries
#18
Torsten P Vahl, Pawel Gasior, Carlos A Gongora, Kamal Ramzipoor, Chang Lee, Yanping Cheng, Jenn McGregor, Masahiko Shibuya, Edward A Estrada, Gerard B Conditt, Greg L Kaluz, Juan F Granada
AIMS: The vascular healing profile of polymers used in bioresorbable vascular scaffolds (BRS) has not been fully characterised in the absence of antiproliferative drugs. In this study, we aimed to compare the polymer biocompatibility profile and vascular healing response of a novel ultrahigh molecular weight amorphous PLLA BRS (FORTITUDE®; Amaranth Medical, Mountain View, CA, USA) against bare metal stent (BMS) controls in porcine coronary arteries. METHODS AND RESULTS: Following device implantation, optical coherence tomography (OCT) evaluation was performed at 0 and 28 days, and at one, two, three and four years...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27997964/treatment-of-biliary-strictures-with-fully-covered-self-expandable-metal-stents-after-pancreaticoduodenectomy
#19
Hitoshi Shibuya, Kazuo Hara, Nobumasa Mizuno, Susumu Hijioka, Hiroshi Imaoka, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Tsukasa Yoshida, Nozomi Okuno, Nobuhiro Hieda, Patommatat Bhanthumkomol, Yasuhiro Shimizu, Yoshiki Senda, Seiji Natsume, Yasumasa Niwa, Kenji Yamao
Background and study aims Anastomotic stricture is a late complication after biliary reconstructive surgery, but standard treatments are currently lacking. We selected patients who had undergone pancreaticoduodenectomy and Child's procedure, and aimed to evaluate the safety and efficacy of temporary placement of fully covered self-expandable metal stents (FCSEMSs) to treat postoperative anastomotic stricture. Patients and methods This study retrospectively analyzed 13 patients who underwent treatment with FCSEMSs for anastomotic stricture between June 2011 and March 2016...
January 2017: Endoscopy
https://www.readbyqxmd.com/read/27996218/association-of-early-physical-activity-time-with-pain-activities-of-daily-living-and-progression-of-vertebral-body-collapse-in-patients-with-vertebral-compression-fractures-an-observational-study-at-single-institution
#20
Hideki Kataoka, Tatsunori Ikemoto, Ayana Yoshimura, Mihoko Shibuya, Kyo Goto, Jyunichirou Yamashita, Kaoru Morita, Jyunya Sakamoto, Jiro Nakano, Minoru Okita
BACKGROUND: Physical activity can reduce pain and improve the ability to perform daily activities in patients with acute low back pain (LBP) due to various non-specific causes. The association between physical activity during the early phase of acute vertebral compression fractures (VCFs) and rehabilitation outcomes is unknown. AIM: To investigate the effects of early physical activity time (EPAT) on pain following acute VCFs, recovery of the ability to perform activities of daily living (ADLs), and progression of fractured vertebral body collapse...
December 19, 2016: European Journal of Physical and Rehabilitation Medicine
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