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Takashi Shibuya, Nobutoshi Fushimi, Miyuka Kawai, Yohei Yoshida, Hiroki Hachiya, Shun Ito, Hiromi Kawai, Noritsugu Ohashi, Akihiro Mori
Non-alcoholic fatty liver disease (NAFLD) often coexists with type 2 diabetes (T2D), and its prevalence in patients with T2D is estimated to be approximately 50%-60% in Japan.(1) In some patients with T2D, NAFLD can progress to non-alcoholic steatohepatitis (NASH) and further to liver cirrhosis and hepatocellular carcinoma (HCC).(2) Moreover, NAFLD is considered an independent risk factor for cardiovascular events.(3).
July 18, 2017: Diabetes, Obesity & Metabolism
Yuemeng Ji, Jun Zhao, Hajime Terazono, Kentaro Misawa, Nicholas P Levitt, Yixin Li, Yun Lin, Jianfei Peng, Yuan Wang, Lian Duan, Bowen Pan, Fang Zhang, Xidan Feng, Taicheng An, Wilmarie Marrero-Ortiz, Jeremiah Secrest, Annie L Zhang, Kazuhiko Shibuya, Mario J Molina, Renyi Zhang
Photochemical oxidation of aromatic hydrocarbons leads to tropospheric ozone and secondary organic aerosol (SOA) formation, with profound implications for air quality, human health, and climate. Toluene is the most abundant aromatic compound under urban environments, but its detailed chemical oxidation mechanism remains uncertain. From combined laboratory experiments and quantum chemical calculations, we show a toluene oxidation mechanism that is different from the one adopted in current atmospheric models...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
Toru Nakasugi, Takushi Murakawa, Koji Shibuya, Masanori Morimoto
A deodorizing substance in black cumin (Nigella sativa L.), a spice for curry and vegetable foods in Southwest Asia, was examined. The essential oil prepared from the seeds of this plant exhibited strong deodorizing activity against methyl mercaptan, which is a main factor in oral malodor. After purification with silica gel column chromatography, the active substance in black cumin seed oil was identified as thymoquinone. This monoterpenic quinone functions as the main deodorizing substance in this oil against methyl mercaptan...
July 12, 2017: Journal of Oleo Science
Yuri Uemura, Takuya Oshima, Munetaka Yamamoto, Charles Jourdan Reyes, Pedro Henrique Costa Cruz, Toshiharu Shibuya, Yukio Kawahara
Matrin3 is an RNA-binding protein that is localized in the nuclear matrix. Although various roles in RNA metabolism have been reported for Matrin3, in vivo target RNAs to which Matrin3 binds directly have not been investigated comprehensively so far. Here, we show that Matrin3 binds predominantly to intronic regions of pre-mRNAs. Photoactivatable Ribonucleoside-Enhanced Cross-linking and Immunoprecipitation (PAR-CLIP) analysis using human neuronal cells showed that Matrin3 recognized pyrimidine-rich sequences as binding motifs, including the polypyrimidine tract, a splicing regulatory element...
July 11, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Takashi Makino, Yoshinobu Hata, Hajime Otsuka, Satoshi Koezuka, Nao Kikuchi, Kazutoshi Isobe, Naobumi Tochigi, Kazutoshi Shibuya, Sakae Homma, Akira Iyoda
The current study presents the case of a 66-year-old male presenting with fever and chest pain. Chest enhanced computed tomography scanning revealed a mass shadow in the right upper lobe with chest wall invasion. 18-Fluorodeoxyglucose-positron emission tomography (FDG-PET) identified the localized uptake of the mass lesion in the right upper lobe, in addition to diffuse uptake by the bone marrow. The laboratory data on admission revealed marked leukocytosis and an elevated C-reactive protein level (CRP). Serum concentrations of granulocyte colony-stimulating factor (G-CSF) and interleukin 6 were increased...
July 2017: Molecular and Clinical Oncology
Yoshihiko Yamamoto, Yuta Okude, Shota Mori, Masatoshi Shibuya
Cycloaddition reactions of 1,6-diynes bearing methyl terminal groups with p-anisaldehyde were conducted using a cationic ruthenium catalyst with a η(5)-pentamethylcyclopentadienyl ligand in THF at room temperature to afford dienyl ketones via ring opening of the initially formed fused pyrans. (Z)-Stereoisomers of dienyl ketones were selectively obtained using the ruthenium catalyst, whereas previously reported rhodium catalysts produced (E)-isomers. These (E)- and (Z)-selectivities are kinetically controlled as the control experiments showed that the E/Z-isomerization of (E)-dienylketone occurs at 70 °C for 10 h to afford an E/Z-ratio of almost 1:1...
July 14, 2017: Journal of Organic Chemistry
T Shiinoki, S Kawamura, T Uehara, Y Yuasa, K Fujimoto, M Koike, T Sera, Y Emoto, H Hanazawa, K Shibuya
No abstract text is available yet for this article.
July 2017: Journal of Applied Clinical Medical Physics
Soichi Shibuya, Toru Nakamura, Eiji Miyazaki
Anatomical segmentectomy is an advantageous procedure because it spares healthy lung that has potential to show compensatory growth after lung resection and decreases the risk of air leak and residual resection, which becomes a problem in wedge resection. However, anatomical segmentectomy has not become a common procedure in pediatrics because it requires more complicated procedure than lobectomy or wedge resection, especially in patients with a history of pulmonary infection. In this case report, anatomical basal segmentectomy was safely performed with magnified vision by a hybrid video-assisted thoracic surgery (VATS) approach in a 6-year-old girl with intralobar pulmonary sequestration after severe pneumonia...
January 2017: European Journal of Pediatric Surgery Reports
Kengo Shibata, Hideki Kawamura, Nobuki Ichikawa, Kazuaki Shibuya, Tadashi Yoshida, Yosuke Ohno, Shigenori Homma, Akinobu Taketomi
Situs inversus totalis (SIT) is a rare congenital anomaly. Generally, laparoscopic surgery is difficult to perform in patients with SIT because of both the potential challenges associated with unexpected vascular anomalies and the lack of standardized strategy for handling such cases. This is the first report of laparoscopic total gastrectomy with lymph node dissection for advanced gastric cancer in a patient with SIT. A 79-year-old man with SIT was diagnosed with advanced gastric cancer. We performed laparoscopic total gastrectomy with modified D2 lymph node dissection (D2 without splenectomy) and esophagojejunal anastomosis using an overlap method involving retrocolic Roux-en-Y reconstruction...
July 5, 2017: Asian Journal of Endoscopic Surgery
Nobutoshi Fushimi, Munenori Yamada, Hiroki Hachiya, Shun Ito, Takashi Shibuya, Noritsugu Ohashi, Akihiro Mori
AIM: Glutamine has various beneficial functions in the gastrointestinal tract. The present study was designed to investigate the effect of two different glutamine supplements on bowel movement at the start of enteral feeding in elderly inpatients. METHODS: This was a double-blind, prospective, randomized comparison study. A total of 25 patients aged >75 years recovering from a critical illness in a non-intensive care unit and scheduled for tube feeding were recruited...
July 4, 2017: Geriatrics & Gerontology International
Marie Murakawa, Kazumoto Shibuya, Yukari Sekiguchi, Satoshi Kuwabara
No abstract text is available yet for this article.
2017: Internal Medicine
Suchunya Aungkulanon, Viroj Tangcharoensathien, Kenji Shibuya, Kanitta Bundhamcharoen, Virasakdi Chongsuvivatwong
BACKGROUND: Despite achievement of universal health coverage in Thailand, socioeconomic inequality in health has been a major policy concern. This study examined mortality patterns across different socioeconomic strata in Thailand. METHODS: We conducted a cross-sectional analysis of the 2010 Population and Housing Census on area-level socioeconomic deprivation against the 2010 mortality from the vital registration database at the super-district level. We used principal components analysis to construct a socioeconomic deprivation index and K-mean cluster analysis to group socioeconomic status and cause-specific mortality...
July 3, 2017: International Journal for Equity in Health
Hiroki Kondo, Yohei Shimono, Junko Mukohyama, Yasuteru Tanaka, Naoki Shibuya, Hironobu Minami, Yoshihiro Kakeji, Akira Suzuki
BACKGROUND: Intronic microRNAs (miRNAs) are considered to be transcribed using their host gene promoter. However, about one third of intronic miRNAs are predicted to have independent promoter elements. MATERIALS AND METHODS: Human breast cancer cells were cultured under normoxia or hypoxia, and expression levels of intronic miR-106b-25 cluster miRNAs and their host gene minichromosome maintenance complex component 7 (MCM7) transcripts were analyzed by semi-quantitative polymerase chain reaction...
July 2017: Anticancer Research
Hanae Saida, Eiichi Ishikawa, Noriaki Sakamoto, Takuma Hara, Toshitsugu Terakado, Tomohiko Masumoto, Hiroyoshi Akutsu, Makoto Shibuya, Tetsuya Yamamoto, Shingo Takano, Akira Matsumura
We report the case of a 40-year-old man presenting with focal headache and a bulge at the right parietal bone, diagnosed as an intradiploic arachnoid cyst. The cyst wall included "meningothelial hyperplasia," which is a rare finding. While over 40 cases of intradiploic arachnoid cysts have been reported to date, meningothelial hyperplasia in an intradiploic arachnoid cyst does not appear to have been reported. We also discuss the pathological findings of arachnoid cysts with meningothelial hyperplasia and mechanisms of enlargement of the arachnoid cyst...
January 2017: NMC Case Rep J
Tsutomu Takeda, Daisuke Asaoka, Yuzuru Tajima, Kenshi Matsumoto, Naoto Takeda, Takahumi Hiromoto, Shoki Okubo, Hiroaki Saito, Tomonori Aoyama, Tomoyoshi Shibuya, Naoto Sakamoto, Mariko Hojo, Taro Osada, Akihito Nagahara, Takashi Yao, Sumio Watanabe
We report a rare case of hemorrhagic gastric polyps resulting in anemia during long-term proton pump inhibitor (PPI) administration that endoscopically looked like a fundic gland polyp (FGP). A 44-year-old man presented complaining of anemia and tarry stools. Esophagogastroduodenoscopy (EGD) demonstrated multiple white edematous polyps in the corpus and antrum, which were considered to be FGPs. We attempted endoscopic hemostasis but hemorrhaging increased because of hemorrhagic polyps and vulnerable gastric mucosa...
June 28, 2017: Clinical Journal of Gastroenterology
Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Naofumi Shinmyo, Ikuo Otsuka, Shujiro Okuda, Emiko Inoue, Hirofumi Igeta, Masako Shibuya, Jun Egawa, Naoki Orime, Ichiro Sora, Toshiyuki Someya
AIM: Rare gene variations are thought to confer substantial risk for schizophrenia. We performed a three-stage study to identify rare variations that have a strong impact on the risk of developing schizophrenia. METHODS: In the first stage, we prioritized rare missense variations using whole-exome sequencing (WES) data from three families, consisting of a proband, an affected sibling, and parents. In the second stage, we performed targeted resequencing of the PDCD11 coding region in 96 patients...
June 28, 2017: Psychiatry and Clinical Neurosciences
Kousuke Kubota, Hisashi Hidaka, Takahide Nakazawa, Yusuke Okuwaki, Keiko Yamane, Tomoyoshi Inoue, Haruki Uojima, Juichi Takada, Yoshiaki Tanaka, Akitaka Shibuya, Kaoru Fujii, Reiko Woodhams, Keiji Matsunaga, Shigehiro Kokubu, Wasaburo Koizumi
AIM: Transcatheter arterial chemoembolization (TACE) has been recognized as a treatment option for patients with intermediate hepatocellular carcinoma (HCC). This randomized, controlled study compared the local control efficacy of TACE with miriplatin (platinum monohydrate) or with epirubicin. METHODS: The study population consisted of 200 Japanese patients with unresectable HCC at the Kitasato University East Hospital between July 2010 and June 2013. The primary endpoint of the study was time to tumor progression (TTP)...
June 28, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Tomoaki Koshizawa, Toshiharu Morimoto, Gen Watanabe, Toshiaki Watanabe, Nao Yamasaki, Yoshikazu Sawada, Tomoaki Fukuda, Ayumu Okuda, Kimiyuki Shibuya, Tadaaki Ohgiya
We describe the discovery and optimization of a novel series of furo[3,2-d]pyrimidines as G protein-coupled receptor 119 agonists. Agonistic activity of 4 (EC50=129nM) was improved by replacing the intramolecular hydrogen bond between the fluorine atom and the aniline hydrogen in the head moiety with a covalent C-C bond to enhance conformational restriction, which consequently gave a lead compound 12 (EC50=53nM). Optimized compound 26, which was identified by the further optimization of 12, exhibited potent activity (EC50=42nM) with improved clearance in liver microsomes and induced a 33% reduction in blood glucose area under the curve at a dose of 10mg/kg in an oral glucose tolerance test in C57BL/6N mice...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
Makoto Aoki, Hiroyuki Tokue, Kei Shibuya, Masato Murata, Shuichi Hagiwara, Kiyohiro Oshima
Whole-body enhanced computed tomography of a septuagenarian woman hit by a truck revealed a traumatic aortic dissection (Stanford B) and arterial bleeding from the right lumbar artery in the right iliopsoas muscle. Angiography revealed an active arterial extravasation from a false lumen of the left lumbar artery. We performed a transcatheter arterial embolization (TAE) of the right lumbar artery. After fenestration of the intimal flap, the left lumbar artery was successfully selected and embolized; the patient's clinical condition subsequently stabilized...
June 21, 2017: Annals of Vascular Surgery
Shuichi Shibuya, Ikuyo Sakaguchi, Shintaro Ito, Eiko Kato, Kenji Watanabe, Naotaka Izuo, Takahiko Shimizu
Ascorbic acid (AA) possesses multiple beneficial functions, such as regulating collagen biosynthesis and redox balance in the skin. AA derivatives have been developed to overcome this compound's high fragility and to assist with AA supplementation to the skin. However, how AA derivatives are transferred into cells and converted to AA in the skin remains unclear. In the present study, we showed that AA treatment failed to increase the cellular AA level in the presence of AA transporter inhibitors, indicating an AA transporter-dependent action...
June 22, 2017: Nutrients
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