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https://www.readbyqxmd.com/read/29920536/toxic-wavelength-of-blue-light-changes-as-insects-grow
#1
Kazuki Shibuya, Shun Onodera, Masatoshi Hori
Short-wavelength visible light (blue light: 400-500 nm) has lethal effects on various insects, such as fruit flies, mosquitoes, and flour beetles. However, the most toxic wavelengths of blue light might differ across developmental stages. Here, we investigate how the toxicity of blue light changes with the developmental stages of an insect by irradiating Drosophila melanogaster with different wavelengths of blue light. Specifically, the lethal effect on eggs increased at shorter light wavelengths (i.e., toward 405 nm)...
2018: PloS One
https://www.readbyqxmd.com/read/29916481/endoscopic-treatment-of-large-impacted-pancreatic-ductal-stone-using-digital-pancreatoscopy-and-electrohydraulic-lithotripsy
#2
Hitoshi Shibuya, Hisatomo Ikehara, Emmanuel Coronel, Takuji Gotoda, Takao Itoi
No abstract text is available yet for this article.
March 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29915920/successful-treatment-of-isolated-bile-leakage-after-hepatectomy-combination-therapy-with-percutaneous-transhepatic-portal-embolization-and-bile-duct-ablation-with-ethanol-a-case-report
#3
Norio Kubo, Norifumi Harimoto, Kei Shibuya, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Kenichiro Araki, Masaya Miyazaki, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Bile leakage after hepatectomy still causes relatively serious problems, and some types of bile leakage are intractable. CASE PRESENTATION: We report a case of postoperative isolated bile duct leakage managed successfully by combination therapy of percutaneous transhepatic portal vein embolization (PTPE) and bile duct ablation with ethanol. A 61-year-old man diagnosed with hepatocellular carcinoma underwent partial hepatectomy. On postoperative day 1, bile leakage was detected at the drainage tube...
June 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29913249/variations-in-the-viral-genome-and-biological-properties-of-bovine-leukemia-virus-wild-type-strains
#4
Hironobu Murakami, Jumpei Uchiyama, Chihiro Suzuki, Sae Nikaido, Kaho Shibuya, Reiichiro Sato, Yosuke Maeda, Michiko Tomioka, Shin-Nosuke Takeshima, Hajime Kato, Masahiro Sakaguchi, Hiroshi Sentsui, Yoko Aida, Kenji Tsukamoto
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis (EBL), which causes enormous economic losses in the livestock industry worldwide. To reduce the economic loss caused by BLV infection, it is important to clarify the characters associated with BLV transmissibility and pathogenesis in cattle. In this study, we focused on viral characters and examined spontaneous mutations in the virus and viral properties by analyses of whole genome sequences and BLV molecular clones derived from cows with and without EBL...
June 15, 2018: Virus Research
https://www.readbyqxmd.com/read/29908706/conscious-sedation-with-midazolam-intravenously-for-a-patient-with-parkinson-s-disease-and-unpredictable-chorea-like-dyskinesia
#5
M Shibuya, T Hojo, Y Hase, T Fujisawa
Oral surgery can be difficult in patients with chorea-like dyskinesia, which is common in those on long-term levodopa medication for Parkinson's disease, and we know of no conclusive evidence to indicate whether conscious sedation with midazolam is effective in such cases. We report a patient in whom levodopa-induced chorea-like dyskinesia disappeared when midazolam was given intravenously for conscious sedation.
June 13, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29902562/sacciform-cells-in-the-epidermis-of-fugu-takifugu-rubripes-produce-and-secrete-kalliklectin-a-novel-lectin-found-in-teleosts
#6
Shigeyuki Tsutsui, Yuya Suzuki, Ko Shibuya, Osamu Nakamura
Kalliklectin is a novel lectin identified in the skin mucus and blood plasma of teleosts, including fugu (Takifugu rubripes). It has been found to exhibit sequence similarity to mammalian plasma kallikrein and coagulation factor XI. The objective of the present study was to clarify the cellular localization of kalliklectin using an antiserum specific to fugu kalliklectin. Immunohistochemical analysis showed that positive reactions were observed in the skin and liver, but not in other tested tissues. Several types of epidermal cells were stained by the antiserum; sacciform cells were one of the types of cells most densely stained by the antiserum in adult fugu skin, whereas mucous cells showed negative staining results...
June 11, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29901607/membranoproliferative-glomerulonephritis-like-findings-for-tafro-syndrome-associated-with-an-anterior-mediastinal-tumor-a-case-report
#7
Yoshitaka Furuto, Hirotsugu Hashimoto, Hajime Horiuti, Yuko Shibuya
RATIONALE: TAFRO syndrome is a systemic inflammatory disease proposed recently from Japan. The cause of TAFRO syndrome is unclear. Moreover, the disease characteristics and kidney pathology are yet unknown well and there are few cases. Herein, we report a patient with TAFRO syndrome and present the features of the renal histopathology. PATIENT CONCERNS: A 55-year-old woman presented to our hospital with the main complaint of subacute dyspnoea. DIAGNOSIS: Physical findings included a low-grade fever and generalised oedema...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900664/tschimganine-and-its-derivatives-extend-the-chronological-life-span-of-yeast-via-activation-of-the-sty1-pathway
#8
Takahide Hibi, Hokuto Ohtsuka, Takafumi Shimasaki, Shougo Inui, Masatoshi Shibuya, Hideki Tatsukawa, Kei Kanie, Yoshihiko Yamamoto, Hirofumi Aiba
Most antiaging factors or life span extenders are associated with calorie restriction (CR). Very few of these factors function independently of, or additively with, CR. In this study, we focused on tschimganine, a compound that was reported to extend chronological life span (CLS). Although tschimganine led to the extension of CLS, it also inhibited yeast cell growth. We acquired a Schizosaccharomyces pombe mutant with a tolerance for tschimganine due to the gene crm1. The resulting Crm1 protein appears to export the stress-activated protein kinase Sty1 from the nucleus to the cytosol even under stressful conditions...
June 14, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29896400/carcinoma-in-the-residual-rectum-of-a-long-standing-crohn-s-disease-patient-following-subtotal-colectomy-a-case-report
#9
Kazuaki Shibuya, Shigenori Homma, Tadashi Yoshida, Yosuke Ohno, Nobuki Ichikawa, Hideki Kawamura, Teppei Imamoto, Yoshihiro Matsuno, Akinobu Taketomi
The development of colorectal cancer in long-standing Crohn's disease (CD) patients has become a major complication. Therapeutic guidelines for CD-associated cancer (CDAC) have already been established in Western countries; however, specific guidelines are not currently available in Japan. Surveillance of the residual intestine for cancer screening is important for long-standing CD patients. The present case report describes the occurrence of rectal carcinoma in a patient with a 25-year history of CD. A 37-year-old male with a 17-year history of CD underwent semi-emergent subtotal colectomy and ileostomy for bowel obstruction secondary to the transverse colon stenosis, and multiple severe stenosis and inflammation...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29884863/instability-of-the-16s-rrna-methyltransferase-encoding-npma-gene-why-have-bacterial-cells-possessing-npma-not-spread-despite-their-high-and-broad-resistance-to-aminoglycosides
#10
Yoshimasa Ishizaki, Yuko Shibuya, Chigusa Hayashi, Kunio Inoue, Teruo Kirikae, Tatsuya Tada, Tohru Miyoshi-Akiyama, Masayuki Igarashi
The NpmA bacterial 16S rRNA methyltransferase, which is identified from Escherichia coli strains, confers high resistance to many types of aminoglycoside upon its host cells. But despite its resistance-conferring ability, only two cases of its isolation from E. coli (14 years apart) have been reported to date. Here, we investigated the effect of the npmA gene on aminoglycoside resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae and its stability in E. coli cells by comparing it with armA, another 16S rRNA methyltransferase gene currently spreading globally...
June 8, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29883136/final-results-of-the-opera-experiment-on-%C3%AE-_-%C3%AF-appearance-in-the-cngs-neutrino-beam
#11
N Agafonova, A Alexandrov, A Anokhina, S Aoki, A Ariga, T Ariga, A Bertolin, C Bozza, R Brugnera, A Buonaura, S Buontempo, M Chernyavskiy, A Chukanov, L Consiglio, N D'Ambrosio, G De Lellis, M De Serio, P Del Amo Sanchez, A Di Crescenzo, D Di Ferdinando, N Di Marco, S Dmitrievsky, M Dracos, D Duchesneau, S Dusini, T Dzhatdoev, J Ebert, A Ereditato, J Favier, R A Fini, F Fornari, T Fukuda, G Galati, A Garfagnini, V Gentile, J Goldberg, S Gorbunov, Y Gornushkin, G Grella, A M Guler, C Gustavino, C Hagner, T Hara, T Hayakawa, A Hollnagel, K Ishiguro, A Iuliano, K Jakovcic, C Jollet, C Kamiscioglu, M Kamiscioglu, S H Kim, N Kitagawa, B Klicek, K Kodama, M Komatsu, U Kose, I Kreslo, F Laudisio, A Lauria, A Ljubicic, A Longhin, P Loverre, M Malenica, A Malgin, G Mandrioli, T Matsuo, V Matveev, N Mauri, E Medinaceli, A Meregaglia, S Mikado, M Miyanishi, F Mizutani, P Monacelli, M C Montesi, K Morishima, M T Muciaccia, N Naganawa, T Naka, M Nakamura, T Nakano, K Niwa, S Ogawa, N Okateva, A Olchevsky, K Ozaki, A Paoloni, L Paparella, B D Park, L Pasqualini, A Pastore, L Patrizii, H Pessard, C Pistillo, D Podgrudkov, N Polukhina, M Pozzato, F Pupilli, M Roda, T Roganova, H Rokujo, G Rosa, O Ryazhskaya, A Sadovsky, O Sato, A Schembri, I Shakiryanova, T Shchedrina, E Shibayama, H Shibuya, T Shiraishi, S Simone, C Sirignano, G Sirri, A Sotnikov, M Spinetti, L Stanco, N Starkov, S M Stellacci, M Stipcevic, P Strolin, S Takahashi, M Tenti, F Terranova, V Tioukov, S Tufanli, A Ustyuzhanin, S Vasina, P Vilain, E Voevodina, L Votano, J L Vuilleumier, G Wilquet, B Wonsak, C S Yoon
The OPERA experiment was designed to study ν_{μ}→ν_{τ} oscillations in the appearance mode in the CERN to Gran Sasso Neutrino beam (CNGS). In this Letter, we report the final analysis of the full data sample collected between 2008 and 2012, corresponding to 17.97×10^{19} protons on target. Selection criteria looser than in previous analyses have produced ten ν_{τ} candidate events, thus reducing the statistical uncertainty in the measurement of the oscillation parameters and of ν_{τ} properties. A multivariate approach for event identification has been applied to the candidate events and the discovery of ν_{τ} appearance is confirmed with an improved significance level of 6...
May 25, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29875520/the-g7-presidency-and-universal-health-coverage-japan-s-contribution
#12
Haruka Sakamoto, Satoshi Ezoe, Kotono Hara, Eiji Hinoshita, Yui Sekitani, Keishi Abe, Haruhiko Inada, Takuma Kato, Kenichi Komada, Masami Miyakawa, Hiroyuki Yamaya, Naoko Yamamoto, Sarah Krull Abe, Kenji Shibuya
Problem: If universal health coverage (UHC) is to be achieved globally, it needs sustained promotion and political awareness and support. Approach: During its presidency of the Group of Seven (G7) industrialized nations in 2016, Japan aimed to raise the issue of UHC to the top of the global health agenda. Local setting: Japan has promoted a health agenda at all of the G7 summits since 2000 that it has hosted. Human security has been the core foundation of Japan's foreign diplomacy for several decades and, consequently, there was no apparent opposition within Japan to the inclusion of UHC on the agenda of the summit in 2016...
May 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29868980/primary-lateral-sclerosis-and-the-amyotrophic-lateral-sclerosis-frontotemporal-dementia-spectrum
#13
Smriti Agarwal, Elizabeth Highton-Williamson, Jashelle Caga, José M Matamala, Thanuja Dharmadasa, James Howells, Margaret C Zoing, Kazumoto Shibuya, Nimeshan Geevasinga, Steve Vucic, John R Hodges, Rebekah M Ahmed, Matthew C Kiernan
AIM: To investigate whether primary lateral sclerosis (PLS) represents part of the amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum of diseases. METHODS: Comprehensive assessment was taken on 21 patients with PLS and results were compared to patients diagnosed with pure motor ALS (n = 27) and ALS-FTD (n = 12). Clinical features, Addenbrooke's Cognitive Examination (ACE) scores, Motor Neuron Disease Behaviour (Mind-B) scores, motor disability on the ALS functional rating scale (ALSFRS) and survival times were documented...
June 4, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29863095/two-year-outcomes-of-anticoagulation-for-acute-ischemic-stroke-with-nonvalvular-atrial-fibrillation-samurai-nvaf-study
#14
Sohei Yoshimura, Masatoshi Koga, Shoichiro Sato, Kenichi Todo, Hiroshi Yamagami, Masaya Kumamoto, Ryo Itabashi, Tadashi Terasaki, Kazumi Kimura, Yoshiki Yagita, Yoshiaki Shiokawa, Kenji Kamiyama, Satoshi Okuda, Yasushi Okada, Shunya Takizawa, Yasuhiro Hasegawa, Tomoaki Kameda, Satoshi Shibuya, Yoshinari Nagakane, Yasuhiro Ito, Hideki Matsuoka, Kazuhiro Takamatsu, Kazutoshi Nishiyama, Kyohei Fujita, Teppei Kamimura, Daisuke Ando, Toshihiro Ide, Takeshi Yoshimoto, Masayuki Shiozawa, Soichiro Matsubara, Yoshitaka Yamaguchi, Naoto Kinoshita, Takayuki Matsuki, Junji Takasugi, Keisuke Tokunaga, Kyoko Higashida, Kazunari Homma, Kazuomi Kario, Shoji Arihiro, Kazunori Toyoda
BACKGROUND: We determined the 2-year long-term risk-benefit profile in patients with stroke or transient ischemic attack (TIA) receiving warfarin or direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry in Japan.Methods and Results:NVAF patients within 7 days after onset of ischemic stroke/TIA were enrolled in 18 stroke centers. Outcome measures included ischemic and bleeding events and death in the 2-year follow-up period...
June 1, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29859814/quantitation-of-sevoflurane-in-whole-blood-and-aqueous-solutions-by-volatile-organic-compound-sensing
#15
Yuri Hase, Kuniaki Suzuki, Nobuhito Kamekura, Makiko Shibuya, Yu Takahashi, Kosuke Namba, Toshiaki Fujisawa
INTRODUCTION: It is difficult to quantify poorly soluble volatile anesthetics in aqueous solutions; this necessitates the development of alternative prompt methods to analyze the in vivo blood concentrations of anesthetics for the clinical assessment of anesthesia depth. In this study, we demonstrated that the difficulties can be overcome by using volatile organic compound (VOC) sensors, which allow the levels of vaporized VOCs to be quantified in several seconds and obviate the need for conventional techniques such as gas chromatography or nuclear magnetic resonance (NMR)...
May 31, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29859670/haemin-induced-cell-death-in-human-monocytic-cells-is-consistent-with-ferroptosis
#16
Shion Imoto, Mari Kono, Takashi Suzuki, Yukiko Shibuya, Tohru Sawamura, Yuji Mizokoshi, Hirohide Sawada, Ayako Ohbuchi, Katsuyasu Saigo
BACKGROUND: Iron overload is a major issue for transfusion-dependent patients. Repeated transfusions result in the loading of large amounts of haem-derived iron on macrophages, and the haemin in turn induces cell death and the generation of reactive oxygen species (ROS) in both murine macrophages and human monocytic THP-1 cells. This haemin-induced cell death process has been shown to be iron-dependent. Thus, we hypothesized that haemin-induced THP-1 cell death is a result of ferroptosis, an iron-dependent mechanism of cell death regulation...
May 29, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29857593/clinical-pharmacy-education-in-japan-using-simulated-patients-in-laboratory-based-communication-skills-training-before-clinical-practice
#17
Rie Kubota, Kiyoshi Shibuya, Yoichi Tanaka, Manahito Aoki, Megumi Shiomi, Wataru Ando, Katsuya Otori, Takako Komiyama
The Japanese pharmaceutical curriculum was extended from four to six years in 2006. Students now receive practical communication-skills training in their fourth year, before progressing to train in hospital and community pharmacies in their fifth year. Kitasato University School of Pharmacy, Tokyo, had established a program to meet these aims before the 2006 guidance. In the present study, we discuss and evaluate the features of this communication-skills training program. This study enrolled 242 fourth-year pharmacy students at Kitasato University...
June 1, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29848909/role-of-fks-gene-in-the-susceptibility-of-pathogenic-fungi-to-echinocandins
#18
Yasuhiro Hori, Kazutoshi Shibuya
Echinocandins are antifungal agents that specifically inhibit the biosynthesis of 1,3-β-D-glucan, a major structural component of fungal cell walls. Echinocandins are recommended as first-line or alternative/salvage therapy for candidiasis and aspergillosis in antifungal guidelines of various countries. Resistance to echinocandins has been reported in recent years. The mechanism of echinocandin resistance involves amino acid substitutions in hot spot regions of the FKS gene product, the catalytic subunit of 1,3-β-D-glucan synthase...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29848713/no-deterioration-in-clinical-outcomes-of-carbon-ion-radiotherapy-for-sarcopenia-patients-with-hepatocellular-carcinoma
#19
Shintaro Shiba, Kei Shibuya, Hiroyuki Katoh, Yoshinori Koyama, Masahiko Okamoto, Takanori Abe, Tatsuya Ohno, Takashi Nakano
BACKGROUND/AIM: The relationship between sarcopenia and prognosis in carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) has not yet been reported, therefore we analyzed the presence or absence of sarcopenia before C-ion RT as a prognostic factor for patients with HCC. PATIENTS AND METHODS: Data were retrospectively collected for patients who had undergone C-ion RT for HCC between September 2010 and December 2016. For defining the presence or absence of sarcopenia, skeletal muscles in the third lumbar vertebrae level were measured...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29845120/successful-endovascular-therapy-in-an-elderly-patient-with-severe-hemorrhage-caused-by-traumatic-injury
#20
Masato Murata, Makoto Aoki, Shuichi Hagiwara, Masao Sekihara, Takayuki Kohri, Kei Shibuya, Norimasa Koike, Dai Miyazaki, Kiyohiro Oshima
An 85-year-old female suffered pelvic fracture, multiple rib fractures, right hemopneumothorax, and blunt abdominal aortic injury in a traffic accident. After transfer to our hospital, transcatheter arterial embolization (TAE) was performed immediately for hemorrhage from the bilateral internal iliac arteries. Enhanced computed tomography (CT) after TAE showed an increase of hematoma and extravasation at the bifurcation of the abdominal aorta. Therefore, emergency abdominal endovascular aortic repair was performed on the same day...
2018: Open Medicine (Warsaw, Poland)
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