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https://www.readbyqxmd.com/read/29456847/curative-resection-of-pancreatic-ductal-adenocarcinoma-developing-in-the-remnant-pancreas-13-years-after-distal-pancreatectomy-for-intraductal-papillary-mucinous-neoplasms-a-case-report
#1
Takahiro Einama, Hirofumi Kamachi, Toshihiro Sakata, Kengo Shibata, Kazuki Wakizaka, Ko Sugiyama, Kazuaki Shibuya, Shingo Shimada, Kenji Wakayama, Tatsuya Orimo, Hideki Yokoo, Toshiya Kamiyama, Tomoko Mitsuhashi, Akinobu Taketomi
Intraductal papillary mucinous neoplasms (IPMNs) are characterized by the papillary proliferation of atypical mucinous epithelial cells in the pancreatic ductal system. There are two recurrence patterns following resection of IPMNs: Metachronous multifocal occurrence of IPMNs, and distinct pancreatic ductal adenocarcinoma (PDAC) in the remnant pancreas. Several recent studies investigated the development of distinct PDAC during follow-up evaluation of IPMNs and the incidence rate ranged from 4.5 to 8%. Thus, IMPNs may be a good predictor for the early detection of PDAC during observation or after the resection of IPMNs...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456846/l-carnitine-supplementation-reduces-the-general-fatigue-of-cancer-patients-during-chemotherapy
#2
Hiroki Matsui, Takahiro Einama, Shunsuke Shichi, Ryo Kanazawa, Kazuaki Shibuya, Takashi Suzuki, Fumihiko Matsuzawa, Taku Hashimoto, Shigenori Homma, Junji Yamamoto, Akinobu Taketomi, Hironori Abe
L-Carnitine (LC) plays an important role in the metabolism of fatty acids, and LC deficiency is associated with a feeling of weakness or general fatigue. Cancer patients receiving chemotherapy often develop LC deficiency, which is considered to be a factor contributing to general fatigue. The aim of the present study was to evaluate the efficacy of LC supplementation as a treatment for general fatigue in cancer patients during chemotherapy. A total of 11 cancer patients who were suffering from general fatigue during chemotherapy in our hospital between September 2014 and December 2015 were examined (6 cases involved adjuvant chemotherapy and 5 cases involved chemotherapy for unresectable or recurrent disease)...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29431262/the-japanese-society-of-pathology-guidelines-on-the-handling-of-pathological-tissue-samples-for-genomic-research-standard-operating-procedures-based-on-empirical-analyses
#3
Yae Kanai, Hiroshi Nishihara, Yohei Miyagi, Tatsuhiro Tsuruyama, Kenichi Taguchi, Hiroto Katoh, Tomoyo Takeuchi, Masahiro Gotoh, Junko Kuramoto, Eri Arai, Hidenori Ojima, Ayako Shibuya, Teruhiko Yoshida, Toshiaki Akahane, Rika Kasajima, Kei-Ichi Morita, Johji Inazawa, Takeshi Sasaki, Masashi Fukayama, Yoshinao Oda
Genome research using appropriately collected pathological tissue samples is expected to yield breakthroughs in the development of biomarkers and identification of therapeutic targets for diseases such as cancers. In this connection, the Japanese Society of Pathology (JSP) has developed "The JSP Guidelines on the Handling of Pathological Tissue Samples for Genomic Research" based on an abundance of data from empirical analyses of tissue samples collected and stored under various conditions. Tissue samples should be collected from appropriate sites within surgically resected specimens, without disturbing the features on which pathological diagnosis is based, while avoiding bleeding or necrotic foci...
February 2018: Pathology International
https://www.readbyqxmd.com/read/29407592/spontaneous-imitative-movements-induced-by-an-illusory-embodied-fake-hand
#4
Satoshi Shibuya, Satoshi Unenaka, Takuro Zama, Sotaro Shimada, Yukari Ohki
In the rubber hand illusion (RHI), individuals perceive a fake hand as their own when the hidden real hand and visible fake hand are synchronously stroked. Several RHI studies have reported that visual manipulation of the embodied fake hand inversely affects the perceptual processing of the observer's own hand (e.g., thermal or pain sensitivity). In this study, we examined whether motor manipulation of the fake hand similarly affects the observer's motor system. Our study employed a novel RHI paradigm wherein stroking was interrupted by unexpected movement of the fake hand (i...
February 2, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29399626/development-of-a-formula-to-correct-particle-enhanced-turbidimetric-inhibition-immunoassay-values-so-that-it-more-precisely-reflects-high-performance-liquid-chromatography-values-for-mycophenolic-acid
#5
Keiichi Nakano, Daiki Iwami, Takehiro Yamada, Ken Morita, Keiko Yasuda, Hitoshi Shibuya, Kaoru Kahata, Nobuo Shinohara, Chikara Shimizu
Background: Mycophenolic acid (MPA) concentration measured by homogeneous particle-enhanced turbidimetric inhibition immunoassay (PETINA) may be overestimated due to its cross-reactivity with pharmacologically inactive MPA glucuronide (MPAG), as well as other minor metabolites, accumulated with renal function impairment or co-administered cyclosporine A. In contrast, high-performance liquid chromatography (HPLC) is precise because it can exclude the cross-reactivity. In this study, we assumed HPLC values for MPA (HPLC-MPA) as a reference and aimed to develop a formula correcting PETINA values for MPA (PETINA-MPA) to more precisely reflect HPLC-MPA...
January 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29393401/pyruvate-kinase-type-m2-contributes-to-the-development-of-pancreatic-ductal-adenocarcinoma-by-regulating-the-production-of-metabolites-and-reactive-oxygen-species
#6
Misa Yokoyama, Nobuhiro Tanuma, Rie Shibuya, Takeharu Shiroki, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Kazunori Yamaguchi, Ikuro Sato, Keiichi Tamai, Kennichi Satoh
The majority of cancer cells maintain a high glycolytic activity and an increased lactate production, even in a well oxygenated environment. This phenomenon is known as the Warburg effect. Previous studies have revealed that various types of cancer selectively express the pyruvate kinase M2 isoform (PKM2), and that PKM2 plays a pivotal role in the Warburg effect. Although elevated PKM2 levels have been observed in pancreatic cancer and other types of cancer, little is known about the biological function of PKM2...
January 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29388878/autophosphorylation-site-y428-is-essential-for-the-in-vivo-activation-of-cerk1
#7
Maruya Suzuki, Takumi Watanabe, Issei Yoshida, Hanae Kaku, Naoto Shibuya
Autophosphorylation of PRR is a critical event for the activation of immune signaling in plant. However, the detailed function of these phosphorylation sites is still not well understood. We analyzed the function of an autophosphorylation site of Arabidopsis CERK1, Y428, in immune signaling. Biochemical characterization of CERK1 mutants transiently expressed in N. benthamiana indicated that Y428 plays a crucial role for the in vivo activation of CERK1, differently from the previous observation by the in vitro kinase assay with its cytoplasmic domain...
February 1, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29387231/long-non-coding-rna-hotair-up-regulates-chemokine-c-c-motif-ligand-2-and-promotes-proliferation-of-macrophages-and-myeloid-derived-suppressor-cells-in-hepatocellular-carcinoma-cell-lines
#8
Yasuyuki Fujisaka, Tomoaki Iwata, Keiichi Tamai, Mao Nakamura, Mai Mochizuki, Rie Shibuya, Kazunori Yamaguchi, Tooru Shimosegawa, Kennichi Satoh
Accumulating evidence demonstrated that Hox antisense intergenic RNA (HOTAIR) serves essential roles in the development and metastasis of several types of cancer. In hepatocellular carcinoma (HCC), high expression of HOTAIR is associated with poor prognosis, and HOTAIR regulates cell migration and proliferation. However, the downstream molecular targets of HOTAIR depend on the cancer cell types, and little is known about the precise molecular mechanisms of HOTAIR involved in cancer development. The present study investigated the role of HOTAIR in HCC cell lines...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29383577/a-case-of-abo-incompatible-blood-transfusion-treated-by-plasma-exchange-therapy-and-continuous-hemodiafiltration
#9
Akio Namikawa, Yuko Shibuya, Haruki Ouchi, Hiroko Takahashi, Yoshitaka Furuto
ABO-incompatible blood transfusion is potentially a life-threatening event. A 74-year-old type O Rh-positive male was accidentally transfused with 280 mL type B Rh-positive red blood cells during open right hemicolectomy, causing ABO-incompatible blood transfusion. Immediately after the transfusion, the patient experienced a hypotension episode followed by acute hemolytic reaction, disseminated intravascular coagulation and acute kidney injury. Plasma exchange therapy was performed to remove anti-B antibody and free hemoglobin because they caused acute hemolytic reaction, disseminated intravascular coagulation, and acute kidney injury...
January 31, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29375138/corrigendum-microbial-metabolites-and-derivatives-targeted-at-inflammation-and-bone-diseases-therapy-chemistry-biological-activity-and-pharmacology
#10
Hayamitsu Adachi, Koichi Nakae, Shuichi Sakamoto, Chisato Nosaka, Sonoko Atsumi, Masabumi Shibuya, Nobuaki Higashi, Motowo Nakajima, Tatsuro Irimura, Yoshio Nishimura
This corrects the article DOI: 10.1038/ja.2017.138.
February 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29373569/efficacy-and-acceptability-of-1-liter-of-polyethylene-glycol-with-ascorbic-acid-vs-2-liters-of-polyethylene-glycol-plus-mosapride-and-sennoside-for-colonoscopy-preparation
#11
Masato Kamei, Tomoyoshi Shibuya, Masahito Takahashi, Masae Makino, Keiichi Haga, Osamu Nomura, Takashi Murakami, Hideaki Ritsuno, Hiroya Ueyama, Tomohiro Kodani, Dai Ishikawa, Kenshi Matsumoto, Naoto Sakamoto, Taro Osada, Tatsuo Ogihara, Sumio Watanabe, Akihito Nagahara
BACKGROUND [color=black]Bowel preparation is an important factor for an optimal outcome of colonoscopy. Recently, polyethylene glycol (PEG) solution has been in common use for bowel cleansing for colonoscopy, but some patients are intolerant of PEG because of taste or volume. A low-volume PEG administered with ascorbic acid solution (PEG-Asc) was designed to improve tolerability, but the administration of this method is more complex than that with PEG alone. This study aimed to compare bowel cleansing efficacy, safety, and tolerability of 1 L PEG-Asc with a 2 L PEG preparation with use of sennosides and mosapride...
January 26, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29362349/-brain-metastasis-of-triple-negative-breast-cancer-after-pathological-complete-response-to-neoadjuvant-chemotherapy-a-case-report
#12
Eiko Sakata, Yuka Endo, Aya Miyahira, Keiji Mio, Koko Yoshida, Hideki Hashidate, Hiroyuki Shibuya, Chihiro Sato, Takeshi Higuchi, Haruhiko Makino
We report the case of a patient with triple negative breast cancer(TNBC)who showed isolated brain metastasis relatively soon after pathological complete response(pCR)to neoadjuvant chemotherapy. A 45-year-old woman with a diagnosis of TNBC(T2N1M0, Stage II B)received neoadjuvant chemotherapy with 5-FU/epirubicin/cyclophosphamide(FEC), followed by docetaxel. After the neoadjuvant chemotherapy, she underwent mastectomy and axillary lymph node dissection. Histological examination of the resected specimens revealed pCR...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29356228/curcuma-sp-derived-dehydrocurdione-induces-heme-oxygenase-1-through-a-michael-reaction-between-its-%C3%AE-%C3%AE-unsaturated-carbonyl-and-keap1
#13
Masatoshi Ohnishi, Tomoka Urasaki, Kyohei Egusa, Chihiro Kunobu, Tomoki Harada, Reika Shinkado, Hitomi Nishi, Shoji Maehara, Chinami Kitamura, Toshiyuki Hata, Kazuyoshi Ohashi, Hirotaka Shibuya, Atsuko Inoue
To elucidate the anti-inflammatory mechanism of Curcuma sp., we investigated whether dehydrocurdione, a sesquiterpene contained in Curcuma sp., induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione was extracted from the rhizome of Curcuma sp., and its purity was verified by high performance liquid chromatography. Treatment with 10-100 μM dehydrocurdione transiently and concentration-dependently increased HO-1 mRNA and protein levels. Docking simulation suggested the presence of the Michael reaction between dehydrocurdione and Kelch-like ECH-associated protein (Keap)1 keeping nuclear factor-erythroid2-related-factor (Nrf)2, a transcription factor, in the cytoplasm...
January 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29355932/dietary-consumption-of-antioxidant-vitamins-and-subsequent-lung-cancer-risk-the-japan-public-health-center-based-prospective-study
#14
Saki Narita, Eiko Saito, Norie Sawada, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Junko Ishihara, Ribeka Takachi, Kenji Shibuya, Manami Inoue, Shoichiro Tsugane
While many epidemiological studies have studied the association between lung cancer risk and fruits and vegetable consumption, the major sources of antioxidant vitamins, only a few have investigated the direct association with antioxidants in consideration of cancer subtypes and smoking status. Here, we examined the association between consumption of antioxidant vitamins and lung cancer risk in one of the largest prospective cohort studies in Japan. We investigated the association of dietary antioxidant vitamins intake, namely retinol, vitamin C, vitamin E, α-carotene, and β-carotene, and subsequent incidence of lung cancer among 38,207 men and 41,498 women in the Japan Public Health Center-based Prospective Study...
January 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29354213/neuroimaging-in-cerebral-small-vessel-disease-update-and-new-concepts
#15
Mika Shibuya, Claudia da Costa Leite, Leandro Tavares Lucato
In recent years, small vessel disease (SVD) has been recognized for its major impact on cognitive impairment in elderly people, where it is often difficult to separate its effects from those of neurodegenerative diseases individually. SVD is a systemic disease, probably related to diffuse endothelial dysfunction, which affects the perforating arterioles, capillaries and venules in the brain. Although often asymptomatic, it is responsible for almost half of all dementia cases and a significant proportion of stroke cases...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29329597/does-cognitive-behavioral-therapy-alter-mental-defeat-and-cognitive-flexibility-in-patients-with-panic-disorder
#16
Shinobu Nagata, Yoichi Seki, Takayuki Shibuya, Mizue Yokoo, Tomokazu Murata, Yoichi Hiramatsu, Fuminori Yamada, Hanae Ibuki, Noriko Minamitani, Naoki Yoshinaga, Muga Kusunoki, Yasushi Inada, Nobuko Kawasoe, Soichiro Adachi, Keiko Oshiro, Daisuke Matsuzawa, Yoshiyuki Hirano, Kensuke Yoshimura, Michiko Nakazato, Masaomi Iyo, Akiko Nakagawa, Eiji Shimizu
OBJECTIVE: Mental defeat and cognitive flexibility have been studied as explanatory factors for depression and posttraumatic stress disorder. This study examined mental defeat and cognitive flexibility scores in patients with panic disorder (PD) before and after cognitive behavioral therapy (CBT), and compared them to those of a gender- and age-matched healthy control group. RESULTS: Patients with PD (n = 15) received 16 weekly individual CBT sessions, and the control group (n = 35) received no treatment...
January 12, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29326457/oral-health-the-sakata-model
#17
T Kumagai, N Kumagai, M Nishi, K Shibuya
No abstract text is available yet for this article.
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29322618/genome-enabled-metabolic-reconstruction-of-dominant-chemosynthetic-colonizers-in-deep-sea-massive-sulfide-deposits
#18
Shingo Kato, Takazo Shibuya, Yoshihiro Takaki, Miho Hirai, Takuro Nunoura, Katsuhiko Suzuki
Deep-sea massive sulfide deposits remaining after ceasing of hydrothermal activity potentially provide energy for a chemosynthetic ecosystem in the dark, cold marine environments. Although yet-uncultivated bacteria in the phylum Nitrospirae and the class Deltaproteobacteria are known to dominate the microbial communities of sulfide deposits at and below the seafloor, their metabolic capabilities remain largely elusive. Here, we reveal the metabolic potential of these yet-uncultivated bacteria in hydrothermally inactive sulfide deposits collected at the Southern Mariana Trough by seafloor drilling...
January 10, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29320766/improved-visibility-of-barrett-s-esophagus-with-linked-color-imaging-inter-and-intra-rater-reliability-and-quantitative-analysis
#19
Tsutomu Takeda, Akihito Nagahara, Kei Ishizuka, Shoki Okubo, Keiichi Haga, Maiko Suzuki, Akihito Nakajima, Hiroyuki Komori, Yoichi Akazawa, Kentaro Izumi, Kohei Matsumoto, Hiroya Ueyama, Yuji Shimada, Kenshi Matsumoto, Daisuke Asaoka, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Mariko Hojo, Shuko Nojiri, Sumio Watanabe
BACKGROUND/AIMS: To evaluate the usefulness of linked color imaging (LCI) and blue LASER imaging (BLI) in Barrett's esophagus (BE) compared with white light imaging (WLI). METHODS: Five expert and trainee endoscopists compared WLI, LCI, and BLI images obtained from 63 patients with short-segment BE. Physicians assessed visibility as follows: 5 (improved), 4 (somewhat improved), 3 (equivalent), 2 (somewhat decreased), and one (decreased). Scores were evaluated to assess visibility...
January 10, 2018: Digestion
https://www.readbyqxmd.com/read/29304162/adrenergic-receptors-inhibit-trpv1-activity-in-the-dorsal-root-ganglion-neurons-of-rats
#20
Yumi Matsushita, Miki Manabe, Naoki Kitamura, Izumi Shibuya
Transient receptor potential vanilloid type 1 (TRPV1) is a polymodal receptor channel that responds to multiple types of stimuli, such as heat, acid, mechanical pressure and some vanilloids. Capsaicin is the most commonly used vanilloid to stimulate TRPV1. TRPV1 channels are expressed in dorsal root ganglion neurons that extend to Aδ- and C-fibers and have a role in the transduction of noxious inputs to the skin into the electrical signals of the sensory nerve. Although noradrenergic nervous systems, including the descending antinociceptive system and the sympathetic nervous system, are known to modulate pain sensation, the functional association between TRPV1 and noradrenaline in primary sensory neurons has rarely been examined...
2018: PloS One
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