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https://www.readbyqxmd.com/read/27904059/comparison-of-characteristics-of-two-topical-therapeutic-agents-for-onychomycosis
#1
Tsuyoshi Shimamura, Akiko Miyamae, Ami Imai, Kozue Hirayanagi, Tomoyuki Iwanaga, Nobuo Kubota, Kazutoshi Shibuya
Two topical therapeutic agents were approved in Japan from 2015 to 2016, adding new options for onychomycosis therapy in the clinical field. In order to confirm the differences of formulation properties and nail pharmacokinetics between 5% luliconazole solution and 10% efinaconazole solution, drug concentration and antifungal activity in the nail were measured after topical treatment using human nail plates. In the in vitro permeation study, concentration of each drug was measured in the transversely sliced nail after single treatment with the two topical therapeutic agents...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27904053/executive-summary-of-japanese-domestic-guidelines-for-management-of-deep-seated-mycosis-2014
#2
Shigeru Kohno, Kazuo Tamura, Yoshihito Niki, Koichi Izumikawa, Shinichi Oka, Kenji Ogawa, Junichi Kadota, Katsuhiko Kamei, Yoshinobu Kanda, Tetsuya Kiuchi, Kazutoshi Shibuya, Syunji Takakura, Toru Takata, Yoshio Takesue, Katsuji Teruya, Issei Tokimatsu, Takahiro Fukuda, Shigefumi Maesaki, Koichi Makimura, Hiroshige Mikamo, Kotaro Mitsutake, Yoshitsugu Miyazaki, Masaaki Mori, Akira Yasuoka, Keiko Yano, Noboru Yamanaka, Minoru Yoshida
No abstract text is available yet for this article.
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27896661/erratum-to-breast-reconstruction-using-free-medial-circumflex-femoral-artery-perforator-flaps-intraoperative-anatomic-study-and-clinical-results
#3
Mai Shibuya, Toshihiko Satake, Reiko Nakasone, Marina Ogawa, Mayu Muto, Kazutaka Narui, Kazunori Yasumura, Takashi Ishikawa, Jiro Maegawa
No abstract text is available yet for this article.
November 28, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27893543/changes-in-intestinal-microbiota-following-combination-therapy-with-fecal-microbial-transplantation-and-antibiotics-for-ulcerative-colitis
#4
Dai Ishikawa, Takashi Sasaki, Taro Osada, Kyoko Kuwahara-Arai, Keiichi Haga, Tomoyoshi Shibuya, Keiichi Hiramatsu, Sumio Watanabe
BACKGROUND: Fecal microbiota transplantation (FMT) is a potential therapeutic approach to restore normal intestinal microbiota in patients with ulcerative colitis (UC), which is associated with dysbiosis; however, treatment efficacy remains unclear. Hence, we studied the impact of antibiotic pretreatment with amoxicillin, fosfomycin, and metronidazole (AFM therapy) and FMT versus AFM alone. METHODS: AFM therapy was administered to patients for 2 weeks until 2 days before FMT...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27893178/comprehensive-genetic-characterization-of-rosette-forming-glioneuronal-tumors-independent-component-analysis-by-tissue-microdissection
#5
Yohei Kitamura, Takashi Komori, Makoto Shibuya, Kentaro Ohara, Yuko Saito, Saeko Hayashi, Aya Sasaki, Eiji Nakagawa, Ryosuke Tomio, Akiyoshi Kakita, Masashi Nakatsukasa, Kazunari Yoshida, Hikaru Sasaki
A rosette-forming glioneuronal tumor (RGNT) is a rare, mixed neuronal-glial tumor characterized by biphasic architecture of glial and neurocytic components. The number of reports of genetic analyses of RGNTs is few. Additionally, the genetic background of the unique biphasic pathological characteristics of such mixed neuronal-glial tumors remains unclear. To clarify the genetic background of RGNTs, we performed separate comprehensive genetic analyses of glial and neurocytic components of five RGNTs, by tissue microdissection...
November 28, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27881685/generation-of-camelid-vhh-bispecific-constructs-via-in-cell-intein-mediated-protein-trans-splicing
#6
Yuki Shibuya, Natsuki Haga, Ryutaro Asano, Hikaru Nakazawa, Takamitsu Hattori, Daisuke Takeda, Aruto Sugiyama, Reiko Kurotani, Izumi Kumagai, Mitsuo Umetsu, Koki Makabe
Production of various combinations of bispecific variable domain of heavy chain of heavy chain-only antibody (VHH) constructs to evaluate their therapeutic potential usually requires several gene-engineering steps. Here, we present an alternative method of creating bispecific VHH constructs in vivo through protein trans-splicing (PTS) reaction; this method may reduce the number of gene manipulation steps required. As a proof-of-concept, we constructed a bispecific antibody (bsAb) containing an anti-epidermal growth factor receptor VHH and anti-green fluorescent protein VHH, and we evaluated and confirmed its bispecificity...
November 23, 2016: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/27876056/post-universal-health-coverage-trend-and-geographical-inequalities-of-mortality-in-thailand
#7
Suchunya Aungkulanon, Viroj Tangcharoensathien, Kenji Shibuya, Kanitta Bundhamcharoen, Virasakdi Chongsuvivatwong
BACKGROUND: Thailand has achieved remarkable improvement in health status since the achievement of universal health coverage in 2002. Health equity has improved significantly. However, challenges on health inequity still remain.This study aimed to determine the trends of geographical inequalities in disease specific mortality in Thailand after the country achieved universal health coverage. METHODS: National vital registration data from 2001 to 2014 were used to calculate age-adjusted mortality rate and standardized mortality ratio (SMR)...
November 22, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27864689/epstein-barr-virus-infection-and-gene-promoter-hypermethylation-in-rheumatoid-arthritis-patients-with-methotrexate-associated-b-cell-lymphoproliferative-disorders
#8
Kozue Ejima-Yamada, Yumi Oshiro, Seiichi Okamura, Tomoaki Fujisaki, Yasuhito Mihashi, Kazuo Tamura, Tomoko Fukushige, Masaru Kojima, Kazutoshi Shibuya, Morishige Takeshita
We analyzed CpG-island hypermethylation status in 12 genes of paraffin-embedded tissues from 38 rheumatoid arthritis (RA) patients with methotrexate (MTX)-associated large B cell lymphoproliferative disorder (BLPD), 11 RA patients with non-MTX-associated BLPD (non-MTX-BLPD), 22 controls with diffuse large B cell lymphoma (DLBCL), and 10 controls with Epstein-Barr virus (EBV)(+) DLBCL. Among them, tumor cells from EBV(+) MTX-BLPD patients and control EBV(+) DLBCL patients had significantly lower median incidence of CpG island methylator phenotype (CIMP) than those from non-MTX-BLPD and control DLBCL groups (2...
November 18, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27862798/catalytic-2-2-1-synthesis-of-fused-thiophenes-using-thiocarbonyls-as-sulfur-donors
#9
Kazuma Matsui, Masatoshi Shibuya, Yoshihiko Yamamoto
The use of N-(p-chlorophenyl)methylbenzoxazole-2-thione as a sulfur-atom donor enables the catalytic [2+2+1] cycloaddition of diynes in wet DMF at 80 °C when open to air, thus affording diverse fused thiophenes with good yields and wide functional-group compatibility. A plausible mechanism, involving a cationic ruthenacycle intermediate, was also proposed on the basis of several control experiments.
November 11, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27836913/immunoreceptor-cd300a-on-mast-cells-and-dendritic-cells-regulates-neutrophil-recruitment-in-a-murine-model-of-sepsis
#10
Kankanam Gamage Sanath Udayanga, Yoshiyuki Nakamura, Chigusa Nakahashi-Oda, Akira Shibuya
Sepsis is a life-threatening syndrome caused by abnormal host immune responses against bacterial infection. Although innate immune cells are known to be important in the pathogenesis of sepsis, how their activation is regulated during sepsis remains incompletely understood. Here we examined the role of the inhibitory immunoreceptor CD300a, which is expressed on various types of myeloid cells, in the pathogenesis of sepsis induced by cecal ligation and puncture (CLP). To this end, we used mice in which CD300a was specifically deleted on mast cells (MCs; Cd300a(fl/fl) Mcpt5-Cre), dendritic cells (DCs; Cd300a(fl/fl) Itgax-Cre), or macrophages and neutrophils (Cd300a(fl/fl) Lyz2-Cre)...
November 11, 2016: International Immunology
https://www.readbyqxmd.com/read/27813454/growth-performances-and-changes-of-macronutrient-ion-concentrations-in-the-culture-medium-when-euglena-gracilis-was-cultured-with-nitrified-digestate
#11
Kenji Takemura, Ryosuke Endo, Toshio Shibuya, Yoshiaki Kitaya
We investigated the possibility of using Euglena gracilis to convert digestate from methane fermentation of organic wastes into a medium for soilless crop culture. The growth of E. gracilis cultured with aqueous solutions containing filtrate of raw digestate at 1-30% (v/v) and nitrified digestate at 10-100% (v/v) was examined. Concentrations of plant macronutrient ions in nitrified digestate before and after culturing E. gracilis were also examined. Specific growth rates in aqueous solutions containing filtrate of raw digestate at 1-10% and nitrified digestate at 10-100% showed no significant differences, respectively (0...
November 30, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27809364/continuation-of-anti-thrombotic-therapy-may-be-associated-with-a-high-incidence-of-colonic-post-polypectomy-bleeding
#12
Tomoyoshi Shibuya, Osamu Nomura, Tomohiro Kodani, Takashi Murakami, Hirofumi Fukushima, Yuzuru Tajima, Kohei Matsumoto, Hideaki Ritsuno, Hiroya Ueyama, Yoshihiro Inami, Dai Ishikawa, Kenshi Matsumoto, Naoto Sakamoto, Taro Osada, Akihito Nagahara, Tatsuo Ogihara, Sumio Watanabe
OBJECTIVES: Post-polypectomy bleeding (PPB) is the most common complication of endoscopic procedures. To reduce the risk of thromboembolic incidents, Japanese guidelines for gastroenterological endoscopy were revised to indicate that antithrombotic agents were not to be discontinued for endoscopic treatment. However, performing endoscopic procedures under antithrombotic medication potentially increases the incidence of hemorrhagic complications. This study investigated the impact of the revised guidelines on the frequency of complications after colonoscopic procedures...
November 3, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27795860/sinus-augmentation-by-platelet-rich-fibrin-alone-a-report-of-two-cases-with-histological-examinations
#13
Naofumi Aoki, Takeo Kanayama, Michinori Maeda, Koichiro Horii, Hironori Miyamoto, Keinoshin Wada, Yasutaka Ojima, Tsukasa Tsuchimochi, Yasuyuki Shibuya
In sinus floor augmentation of an atrophic posterior maxilla, platelet-rich fibrin (PRF) has been used as a graft material. We herein report two cases with histological evaluations of PRF after the surgery. The first case was a 28-year-old female with an atrophic right posterior maxilla who was treated with sinus floor augmentation and simultaneous implant placement using PRF as the sole graft material in our hospital. Twenty-four months after surgery, the implant was unfortunately removed because of occlusal overloading by parafunctional habits...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27788025/a-laboratory-based-analysis-of-nontuberculous-mycobacterial-lung-disease-in-japan-from-2012-to-2013
#14
Kozo Morimoto, Naoki Hasegawa, Kiyohiko Izumi, Ho Namkoong, Kazuhiro Uchimura, Takashi Yoshiyama, Yoshihiko Hoshino, Atsuyuki Kurashima, Jun Sokunaga, Shunsuke Shibuya, Masahiro Shimojima, Manabu Ato, Satoshi Mitarai
RATIONALE: Since 2010, studies that utilize mycobacterial examination results have been widely used to survey nontuberculous mycobacterial (NTM) lung disease. OBJECTIVES: Our study aims to reveal the clinical and epidemiological status of NTM lung disease in Japan. METHODS: All data on the isolation and identification of mycobacteria in 2012 and 2013 were obtained from three dominant commercial laboratories in Japan. Pulmonary disease were defined based on the bacteriological diagnostic criteria issued by the American Thoracic Society and the Infectious Diseases Society of America (ATS/IDSA)...
October 27, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27776450/the-isoflavone-fraction-from-soybean-presents-mrna-maturation-inhibition-activity
#15
Masashi Kurata, Yuki Murata, Keiko Momma, Intisar Fouad Ali Mursi, Masakazu Takahashi, Yusaku Miyamae, Taiho Kambe, Masaya Nagao, Hiroshi Narita, Yasuyuki Shibuya, Seiji Masuda
Recent findings indicate that mRNA splicing inhibitors can be potential anticancer candidates. We have previously established a screening system which monitors mRNA processing in order to identify mRNA processing inhibitors. Among a number of dietary resources, isoflavone fractions showed an inhibitory effect of mRNA processing. These findings demonstrate that a variety of dietary sources have an impact on mRNA biogenesis.
October 25, 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27753601/biological-effect-on-restenosis-and-vascular-healing-of-encapsulated-paclitaxel-nanocrystals-delivered-via-coated-balloon-technology-in-the-familial-hypercholesterolaemic-swine-model-of-in-stent-restenosis
#16
Yanping Cheng, Masahiko Shibuya, Jenn McGregor, Gerard B Conditt, Geng-Hua Yi, Greg L Kaluza, William Gray, Manish Doshi, Prakash Sojitra, Juan F Granada
AIMS: The aim of this study was to evaluate the biological efficacy of a novel lower-dose (2.5 µg/mm2) encapsulated paclitaxel nanocrystal-coated balloon (Nano-PCB) in the familial hypercholesterolaemic swine (FHS) model of iliofemoral in-stent restenosis. METHODS AND RESULTS: Nano-PCB pharmacokinetics were assessed in 20 femoral arteries (domestic swine). Biological efficacy was evaluated in ten FHS: 14 days following bare metal stent implantation each stent segment was randomised to a clinically available PCB (IN...
October 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27752464/primary-pulmonary-glomus-tumor-of-uncertain-malignant-potential-a-case-report-with-literature-review-focusing-on-current-concepts-of-malignancy-grade-estimation
#17
Takashi Oide, Kazuhiro Yasufuku, Kiyoshi Shibuya, Ichiro Yoshino, Yukio Nakatani, Kenzo Hiroshima
We report a 38-year-old woman with a left lung tumor presenting as obstructive pneumonia. Bronchoscopic examination revealed a polypoid tumor filling the left main bronchus. The tumor was partially resected by a snaring procedure for diagnostic purposes. Microscopic examination revealed a submucosal tumor located underneath normal bronchial epithelium. The tumor was composed of sheets of uniform oval to cuboidal cells encompassing numerous blood vessels. Immunohistochemically, the tumor cells exhibited smooth muscle markers, but were negative for neuroendocrine markers...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27752060/preoperative-prediction-for-regaining-ambulatory-ability-in-paretic-non-ambulatory-patients-with-metastatic-spinal-cord-compression
#18
M Ohashi, T Hirano, K Watanabe, K Katsumi, H Shoji, A Sano, H Tashi, I Takahashi, M Wakasugi, Y Shibuya, N Endo
STUDY DESIGN: Retrospective multicenter study. OBJECTIVES: To analyze the predictive factors for postoperative ambulatory recovery in paretic non-ambulatory patients with metastatic spinal cord compression (MSCC). SETTING: Japan. METHODS: Eighty-two consecutive patients (74.4% men; mean age, 66.2 years) who could not walk before surgery due to cervical or thoracic MSCC and underwent posterior decompressive surgery between 2003 and 2014 were included...
October 18, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27746428/major-increases-between-pre-and-post-breakfast-glucose-levels-may-predict-nocturnal-hypoglycemia-in-type-2-diabetes
#19
Soichi Takeishi, Akihiro Mori, Miyuka Kawai, Yohei Yoshida, Hiroki Hachiya, Takayuki Yumura, Shun Ito, Takashi Shibuya, Nobutoshi Fushimi, Noritsugu Ohashi, Hiromi Kawai
Objective The aim of this study was to determine whether nocturnal hypoglycemia may be predicted according to morning glucose levels. Methods We retrospectively evaluated 106 patients with type 2 diabetes who underwent continuous glucose monitoring during admission. The pre-breakfast glucose level (Pre-breakfast level), highest postprandial glucose level within 3 hours after breakfast (Highest level), time from the start of breakfast to the highest postprandial glucose level (Highest time), difference between the pre-breakfast and highest postprandial breakfast glucose levels (Increase), area under the glucose curve (≥180 mg/dL) within 3 hours after breakfast (Morning AUC), post-breakfast glucose gradient (Gradient), and the increase-to-pre-breakfast ratio (Increase/Pre-breakfast) were calculated...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27723721/meiotic-dna-break-formation-requires-the-unsynapsed-chromosome-axis-binding-protein-iho1-ccdc36-in%C3%A2-mice
#20
Marcello Stanzione, Marek Baumann, Frantzeskos Papanikos, Ihsan Dereli, Julian Lange, Angelique Ramlal, Daniel Tränkner, Hiroki Shibuya, Bernard de Massy, Yoshinori Watanabe, Maria Jasin, Scott Keeney, Attila Tóth
DNA double-strand breaks (DSBs) are induced by SPO11 during meiosis to initiate recombination-mediated pairing and synapsis of homologous chromosomes. Germline genome integrity requires spatiotemporal control of DSB formation, which involves the proteinaceous chromosome axis along the core of each meiotic chromosome. In particular, a component of unsynapsed axes, HORMAD1, promotes DSB formation in unsynapsed regions where DSB formation must occur to ensure completion of synapsis. Despite its importance, the underlying mechanism has remained elusive...
November 2016: Nature Cell Biology
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