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https://www.readbyqxmd.com/read/28816937/effect-of-perioperative-oral-care-on-prevention-of-postoperative-pneumonia-associated-with-esophageal-cancer-surgery-a-multicenter-case-control-study-with-propensity-score-matching-analysis
#1
Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Shin-Ichi Yamada, Hiroshi Kurita, Chika Yamauchi, Yasuyuki Shibuya, Yuka Kojima, Hirokazu Nakahara, Takahiko Oho, Masahiro Umeda
The aim of this study was to investigate the effectiveness of oral care in prevention of postoperative pneumonia associated with esophageal cancer surgery.Postoperative pneumonia is a severe adverse event associated with esophageal cancer surgery. It is thought to be caused by aspiration of oropharyngeal fluid containing pathogens. However, the relationship between oral health status and postoperative pneumonia has not been well investigated.This study included 539 patients with esophageal cancer undergoing surgery at 1 of 7 university hospitals...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28776924/updated-meta-analysis-of-cmya5-rs3828611-and-rs4704591-with-schizophrenia-in-asian-populations
#2
Satoshi Hoya, Yuichiro Watanabe, Masako Shibuya, Toshiyuki Someya
AIM: Two single-nucleotide polymorphisms, rs3828611 and rs4704591, in the cardiomyopathy-associated protein 5 (CMYA5) gene have been extensively investigated for associations with schizophrenia in Asian populations, but with conflicting results. To assess the collective evidence across individual studies, we conducted an updated meta-analysis. METHODS: We performed a random-effect model meta-analysis of the associations of rs3828611 and rs4704591 with schizophrenia using seven case-control samples from Asian populations (8074 patients and 8139 controls)...
August 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28776496/regular-hospital-visits-improve-the-prognosis-of-hepatocellular-carcinoma-after-initial-diagnosis-a-single-regional-community-hospital-study
#3
Masaaki Watanabe, Hiroaki Yomokori, Yoshihito Takahashi, Tsutomu Minamino, Hidefumi Kubo, Takemichi Okada, Hitoshi Yamazaki, Akitaka Shibuya, Wasaburo Koizum
BACKGROUND/AIMS: The aims of this study were to investigate the relationship between regular hospital visits and prognosis of hepatocellular carcinoma (HCC) and to suggest methods to avoid poor prognoses in HCC. MATERIALS AND METHODS: In total, 103 patients with initial HCC were classified into 3 groups based on hospital visits occurring 1 year before diagnosis: group A was patients with regular hepatologist visits (n=41), group B was those with regular visits to other hospital divisions (n=50), and group C was those with no hospital visits (n=12)...
August 4, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28772661/novel-pefc-application-for-deuterium-isotope-separation
#4
Hisayoshi Matsushima, Ryota Ogawa, Shota Shibuya, Mikito Ueda
The use of a polymer electrolyte fuel cell (PEFC) with a Nafion membrane for isotopic separation of deuterium (D) was investigated. Mass analysis at the cathode side indicated that D diffused through the membrane and participated in an isotope exchange reaction. The exchange of D with protium (H) in H₂O was facilitated by a Pt catalyst. The anodic data showed that the separation efficiency was dependent on the D concentration in the source gas, whereby the water produced during the operation of the PEFC was more enriched in D as the D concentration of the source gas was increased...
March 16, 2017: Materials
https://www.readbyqxmd.com/read/28768985/polycarbophil-calcium-lodged-in-the-bronchus
#5
Takayoshi Enokido, Hideki Shibuya, Kou Osamura, Michiteru Ohtani
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28768984/primary-pulmonary-meningioma-presenting-as-a-coin-lesion
#6
Takashi Oide, Kenzo Hiroshima, Kiyoshi Shibuya, Yukio Nakatani
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28761086/serotonin-hormonally-regulates-lacrimal-gland-secretory-function-via-the-serotonin-type-3a-receptor
#7
Toshihiro Imada, Shigeru Nakamura, Ryuji Hisamura, Yusuke Izuta, Kai Jin, Masataka Ito, Naoki Kitamura, Kenji F Tanaka, Masaru Mimura, Izumi Shibuya, Kazuo Tsubota
Tears are extracellular fluid secreted from the lacrimal gland (LG). Tears consist of a dynamic tri-layered film composed of secretions from the LG, Meibomian gland, and conjunctival goblet cells. The LG secretes the aqueous component of the tear, the Meibomian gland secretes the lipid component, and conjunctival goblet cells secrete mucin. The regulation of LG activity via the autonomic nervous system has been recognized as fundamental to maintaining aqueous tear flow. Here, we describe the role of a hormone, peripheral serotonin, in tear secretion...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28759681/progress-toward-universal-health-coverage-a-comparative-analysis-in-5-south-asian-countries
#8
Md Mizanur Rahman, Anup Karan, Md Shafiur Rahman, Alexander Parsons, Sarah Krull Abe, Ver Bilano, Rabia Awan, Stuart Gilmour, Kenji Shibuya
Importance: Achieving universal health coverage is one of the key targets in the newly adopted Sustainable Development Goals of the United Nations. Objective: To investigate progress toward universal health coverage in 5 South Asian countries and assess inequalities in health services and financial risk protection indicators. Design and Settings: In a population-based study, nationally representative household (335 373 households) survey data from Afghanistan (2014 and 2015), Bangladesh (2010 and 2014), India (2012 and 2014), Nepal (2014 and 2015), and Pakistan (2014) were used to calculate relative indices of health coverage, financial risk protection, and inequality in coverage among wealth quintiles...
July 31, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28750016/intensity-and-duration-of-neutropenia-relates-to-the-development-of-oral-mucositis-but-not-odontogenic-infection-during-chemotherapy-for-hematological-malignancy
#9
Megumi Kishimoto, Masaya Akashi, Kazuyuki Tsuji, Junya Kusumoto, Shungo Furudoi, Yasuyuki Shibuya, Yumiko Inui, Kimikazu Yakushijin, Shinichiro Kawamoto, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori
BACKGROUND: D-index which combines the intensity and duration of neutropenia is reported as a tool for evaluating the dynamics of neutropenia. This study aimed to analyze the relationship between D-index and oral complications (i.e., oral mucositis [OM] and odontogenic infection [OI]) during chemotherapies for hematological malignancies. METHODS: A total of 421 chemotherapeutic courses in 104 patients were analyzed. Chemotherapeutic courses in patients who finished all of the prophylactic dental treatments were defined as "treatment Finish"...
2017: PloS One
https://www.readbyqxmd.com/read/28740604/identification-of-a-novel-trpm8-agonist-from-nutmeg-a-promising-cooling-compound
#10
Tomohiro Shirai, Kentaro Kumihashi, Mitsuyoshi Sakasai, Hiroshi Kusuoku, Yusuke Shibuya, Atsushi Ohuchi
The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary receptor for innocuous cold stimuli (<28 °C) in humans. TRPM8 agonists such as l-(-)-menthol are widely used as flavors and additives to impart briskness, in addition to medicinal uses for inflammation and pain. Though various natural and synthetic agonists have been explored, only few natural compounds are known. We report herein the identification and characterization of the novel neolignan agonist erythro- and threo-Δ(8')-7-ethoxy-4-hydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan (1) with an EC50 of 0...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28734670/population-health-and-regional-variations-of-disease-burden-in-japan-1990-2015-a-systematic-subnational-analysis-for-the-global-burden-of-disease-study-2015
#11
Shuhei Nomura, Haruka Sakamoto, Scott Glenn, Yusuke Tsugawa, Sarah K Abe, Md M Rahman, Jonathan C Brown, Satoshi Ezoe, Christina Fitzmaurice, Tsuyoshi Inokuchi, Nicholas J Kassebaum, Norito Kawakami, Yosuke Kita, Naoki Kondo, Stephen S Lim, Satoshi Maruyama, Hiroaki Miyata, Meghan D Mooney, Mohsen Naghavi, Tomoko Onoda, Erika Ota, Yuji Otake, Gregory A Roth, Eiko Saito, Takahiro Tabuchi, Yohsuke Takasaki, Tadayuki Tanimura, Manami Uechi, Theo Vos, Haidong Wang, Manami Inoue, Christopher J L Murray, Kenji Shibuya
BACKGROUND: Japan has entered the era of super-ageing and advanced health transition, which is increasingly putting pressure on the sustainability of its health system. The level and pace of this health transition might vary across regions within Japan and concern is growing about increasing regional variations in disease burden. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides a comprehensive, comparable framework. We used data from GBD 2015 with the aim to quantify the burden of disease and injuries, and to attribute risk factors in Japan at a subnational, prefecture-level...
July 19, 2017: Lancet
https://www.readbyqxmd.com/read/28733134/mobility-of-the-first-ray-in-patients-with-or-without-hallux-valgus-deformity-systematic-review-and-meta-analysis
#12
REVIEW
Naohiro Shibuya, Thomas S Roukis, Daniel C Jupiter
The hypermobility theory of the first ray is the reason for the popularization of procedures such as the modified Lapidus procedure involving arthrodesis of the first tarsal-metatarsal joint for correction of hallux valgus deformity. Although many studies have involved motion of the first ray in hallux valgus patients, the presence and clinical significance of hypermobility in the first ray remains controversial. We performed a systematic review and meta-analysis to evaluate the difference in the first ray range of motion between patients with or without hallux valgus deformity...
July 18, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28719078/luseogliflozin-improves-liver-fat-deposition-compared-to-metformin-in-type-2-diabetes-patients-with-non-alcoholic-fatty-liver-disease-a-prospective-randomized-controlled-pilot-study
#13
Takashi Shibuya, Nobutoshi Fushimi, Miyuka Kawai, Yohei Yoshida, Hiroki Hachiya, Shun Ito, Hiromi Kawai, Noritsugu Ohashi, Akihiro Mori
Non-alcoholic fatty liver disease (NAFLD) often coexists with type 2 diabetes (T2D), and its prevalence in patients with T2D is estimated to be approximately 50%-60% in Japan.(1) In some patients with T2D, NAFLD can progress to non-alcoholic steatohepatitis (NASH) and further to liver cirrhosis and hepatocellular carcinoma (HCC).(2) Moreover, NAFLD is considered an independent risk factor for cardiovascular events.(3).
July 18, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28716940/reassessing-the-atmospheric-oxidation-mechanism-of-toluene
#14
Yuemeng Ji, Jun Zhao, Hajime Terazono, Kentaro Misawa, Nicholas P Levitt, Yixin Li, Yun Lin, Jianfei Peng, Yuan Wang, Lian Duan, Bowen Pan, Fang Zhang, Xidan Feng, Taicheng An, Wilmarie Marrero-Ortiz, Jeremiah Secrest, Annie L Zhang, Kazuhiko Shibuya, Mario J Molina, Renyi Zhang
Photochemical oxidation of aromatic hydrocarbons leads to tropospheric ozone and secondary organic aerosol (SOA) formation, with profound implications for air quality, human health, and climate. Toluene is the most abundant aromatic compound under urban environments, but its detailed chemical oxidation mechanism remains uncertain. From combined laboratory experiments and quantum chemical calculations, we show a toluene oxidation mechanism that is different from the one adopted in current atmospheric models...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28701649/deodorizing-substance-in-black-cumin-nigella-sativa-l-seed-oil
#15
Toru Nakasugi, Takushi Murakawa, Koji Shibuya, Masanori Morimoto
A deodorizing substance in black cumin (Nigella sativa L.), a spice for curry and vegetable foods in Southwest Asia, was examined. The essential oil prepared from the seeds of this plant exhibited strong deodorizing activity against methyl mercaptan, which is a main factor in oral malodor. After purification with silica gel column chromatography, the active substance in black cumin seed oil was identified as thymoquinone. This monoterpenic quinone functions as the main deodorizing substance in this oil against methyl mercaptan...
August 1, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28695676/matrin3-binds-directly-to-intronic-pyrimidine-rich-sequences-and-controls-alternative-splicing
#16
Yuri Uemura, Takuya Oshima, Munetaka Yamamoto, Charles Jourdan Reyes, Pedro Henrique Costa Cruz, Toshiharu Shibuya, Yukio Kawahara
Matrin3 is an RNA-binding protein that is localized in the nuclear matrix. Although various roles in RNA metabolism have been reported for Matrin3, in vivo target RNAs to which Matrin3 binds directly have not been investigated comprehensively so far. Here, we show that Matrin3 binds predominantly to intronic regions of pre-mRNAs. Photoactivatable Ribonucleoside-Enhanced Cross-linking and Immunoprecipitation (PAR-CLIP) analysis using human neuronal cells showed that Matrin3 recognized pyrimidine-rich sequences as binding motifs, including the polypyrimidine tract, a splicing regulatory element...
July 11, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28685085/diffuse-fluorodeoxyglucose-positron-uptake-in-the-bone-marrow-of-a-patient-with-granulocyte-colony-stimulating-factor-producing-pleomorphic-carcinoma-of-the-lung-a-case-report
#17
Takashi Makino, Yoshinobu Hata, Hajime Otsuka, Satoshi Koezuka, Nao Kikuchi, Kazutoshi Isobe, Naobumi Tochigi, Kazutoshi Shibuya, Sakae Homma, Akira Iyoda
The current study presents the case of a 66-year-old male presenting with fever and chest pain. Chest enhanced computed tomography scanning revealed a mass shadow in the right upper lobe with chest wall invasion. 18-Fluorodeoxyglucose-positron emission tomography (FDG-PET) identified the localized uptake of the mass lesion in the right upper lobe, in addition to diffuse uptake by the bone marrow. The laboratory data on admission revealed marked leukocytosis and an elevated C-reactive protein level (CRP). Serum concentrations of granulocyte colony-stimulating factor (G-CSF) and interleukin 6 were increased...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28682074/combined-experimental-and-computational-study-on-ruthenium-ii-catalyzed-reactions-of-diynes-with-aldehydes-and-n-n-dimethylformamide
#18
Yoshihiko Yamamoto, Yuta Okude, Shota Mori, Masatoshi Shibuya
Cycloaddition reactions of 1,6-diynes bearing methyl terminal groups with p-anisaldehyde were conducted using a cationic ruthenium catalyst with a η(5)-pentamethylcyclopentadienyl ligand in THF at room temperature to afford dienyl ketones via ring opening of the initially formed fused pyrans. (Z)-Stereoisomers of dienyl ketones were selectively obtained using the ruthenium catalyst, whereas previously reported rhodium catalysts produced (E)-isomers. These (E)- and (Z)-selectivities are kinetically controlled as the control experiments showed that the E/Z-isomerization of (E)-dienylketone occurs at 70 °C for 10 h to afford an E/Z-ratio of almost 1:1...
July 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28681447/-evaluation-of-a-combined-respiratory-gating-system-comprising-the-truebeam-linear-accelerator-and-a-new-real-time-tumor-tracking-radiotherapy-system-a-preliminary-study-jacmp-17-4-2016
#19
T Shiinoki, S Kawamura, T Uehara, Y Yuasa, K Fujimoto, M Koike, T Sera, Y Emoto, H Hanazawa, K Shibuya
No abstract text is available yet for this article.
July 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28680790/anatomical-segmentectomy-with-a-hybrid-vats-approach-in-a-patient-with-intralobar-pulmonary-sequestration-after-severe-pneumonia-a-case-report
#20
Soichi Shibuya, Toru Nakamura, Eiji Miyazaki
Anatomical segmentectomy is an advantageous procedure because it spares healthy lung that has potential to show compensatory growth after lung resection and decreases the risk of air leak and residual resection, which becomes a problem in wedge resection. However, anatomical segmentectomy has not become a common procedure in pediatrics because it requires more complicated procedure than lobectomy or wedge resection, especially in patients with a history of pulmonary infection. In this case report, anatomical basal segmentectomy was safely performed with magnified vision by a hybrid video-assisted thoracic surgery (VATS) approach in a 6-year-old girl with intralobar pulmonary sequestration after severe pneumonia...
January 2017: European Journal of Pediatric Surgery Reports
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