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https://www.readbyqxmd.com/read/29675274/efficacy-and-safety-of-switching-prostaglandin-analog-monotherapy-to-tafluprost-timolol-fixed-combination-therapy
#1
Kazuyoshi Kitamura, Tatsuya Chiba, Fumihiko Mabuchi, Kiyotaka Ishijima, Shu Omoto, Fumiko Kashiwagi, Takashi Godo, Satoshi Kogure, Teruhiko Goto, Takashi Shibuya, Jhoji Tanabe, Shigeo Tsukahara, Tadaharu Tsuchiya, Toyoaki Tsumura, Takaharu Tokunaga, Osamu Hosaka, Tetsunori Saito, Kenji Kashiwagi
Purpose: To assess the efficacy and safety of switching from prostaglandin analog (PGA) monotherapy to tafluprost/timolol fixed-combination (Taf/Tim) therapy. Subjects and Methods: Patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had received PGA monotherapy for at least 3 months were enrolled. Patients were examined at 1, 2, and 3 months after changing therapies. Subsequently, the patients were returned to PGA monotherapy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675164/the-vinylogous-catellani-reaction-a-combined-computational-and-experimental-study
#2
Y Yamamoto, T Murayama, J Jiang, T Yasui, M Shibuya
In the presence of 5 mol% Pd(OAc)2 , 1 equiv. of norbornene, and K2 CO3 , the reaction of 4-iodo-2-quinolones with tertiary o -bromobenzylic alcohols produced the desired benzopyran-fused 2-quinolones in moderate to high yields. A Catellani-type mechanism involving vinylic C-H cleavage is proposed based on the results of control experiments and density functional theory calculations.
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674728/physiological-function-of-phospholipase-d2-in-anti-tumor-immunity-regulation-of-cd8-t-lymphocyte-proliferation
#3
Van Ngo Thai Bich, Tsunaki Hongu, Yuki Miura, Naohiro Katagiri, Norihiko Ohbayashi, Yumi Yamashita-Kanemaru, Akira Shibuya, Yuji Funakoshi, Yasunori Kanaho
Two major phospholipase D (PLD) isozymes in mammals, PLD1 and PLD2, hydrolyze the membrane phospholipid phosphatidylcholine to choline and the lipid messenger phosphatidic acid. Although their roles in cancer cells have been well studied, their functions in tumor microenvironment have not yet been clarified. Here, we demonstrate that PLD2 in cytotoxic CD8+ T cells plays a crucial role in anti-tumor immunity by regulating their cell proliferation. We found that growth of tumors formed by subcutaneously transplanted cancer cells is enhanced in Pld2-knockout mice...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661487/ripk1-downregulation-in-keratinocyte-enhances-trail-signaling-in-psoriasis
#4
Nao Saito, Masaru Honma, Takashi Shibuya, Shin Iinuma, Satomi Igawa, Mari Kishibe, Akemi Ishida-Yamamoto
BACKGROUND: Psoriasis, a common inflammatory skin disorder characterized by scaly erythema and plaques, is induced by dysregulation of dendritic cell- and T cell-mediated immune reaction. Receptor-interacting protein kinase 1 (RIPK1) regulates inflammatory signaling in response to stimuli such as TNF-α, TRAIL, and TLRs, resulting in apoptosis, necroptosis and NF-κB activation. However, the physiological relevance in human epidermis remains elusive. OBJECTIVE: In this study, we examined whether RIPK1 is involved in the pathogenesis of psoriasis vulgaris...
April 10, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29649467/monosodium-glutamate-ingestion-during-the-development-period-reduces-aggression-mediated-by-the-vagus-nerve-in-a-rat-model-of-attention-deficit-hyperactivity-disorder
#5
Ruriko Nishigaki, Yoshihiro Yokoyama, Yuko Shimizu, Ryosuke Marumoto, Sachiyo Misumi, Yoshitomo Ueda, Akimasa Ishida, Yasuyuki Shibuya, Hideki Hida
We used an umami substance, monosodium glutamate (MSG), as a simple stimulant to clarify the mechanism of the formation of emotional behavior. A 60 mM MSG solution was fed to spontaneously hypertensive rats (SHR), used as a model of attention-deficit hyperactivity disorder, from postnatal day 25 for 5 weeks kept in isolation. Emotional behaviors (anxiety and aggression) were then assessed by the open-field test, cylinder test and social interaction test. MSG ingestion during the developmental period resulted in a significant reduction in aggressive behavior but had few effects on anxiety-like behavior...
April 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29648914/tx99-is-a-neutralizing-monoclonal-antibody-against-mouse-tigit
#6
Yuho Nakamura, Keisuke Naito, Yumi Yamashita-Kanemaru, Daisuke Komori, Rei Hirochika, Akira Shibuya, Kazuko Shibuya
T cell immunoglobulin and ITIM domains (TIGIT) is an inhibitory immunoreceptor expressed on NK cells, effector and memory T cells, and regulatory T cells (Tregs). The ligands for TIGIT are CD155 (PVR) and CD112 (PVRL2, nectin-2), which are broadly expressed on hematopoietic cells and nonhematopoietic cells. TIGIT negatively regulates antitumor responses, but promotes autoimmune reaction. Although neutralizing anti-human TIGIT mAbs are under clinical trials for cancers, how the blockade of TIGIT interaction with the ligands shows tumor immunity still remains unclear...
April 12, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29628495/pancreaticoduodenectomy-with-preservation-of-collateral-circulation-or-revascularization-for-biliary-pancreatic-cancer-with-celiac-axis-occlusion-a-report-of-2-cases
#7
Kazuaki Shibuya, Hirofumi Kamachi, Tatsuya Orimo, Akihisa Nagatsu, Shingo Shimada, Kenji Wakayama, Hideki Yokoo, Toshiya Kamiyama, Akinobu Taketomi
BACKGROUND In cases of celiac axis occlusion requiring pancreaticoduodenectomy for malignancy, both oncologic curability and control of hepatic arterial flow must be considered, but the operative strategy is undeveloped. CASE REPORT Case 1: A 74-year-old man was diagnosed with hilar cholangiocarcinoma with celiac axis stenosis. The collateral from the superior mesenteric artery ran through the pancreas head but no invasion was observed in preoperative imaging. Hepatopancreatoduodenectomy with preservation of a collateral was performed...
April 9, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29627772/altered-cerebral-blood-flow-in-the-anterior-cingulate-cortex-is-associated-with-neuropathic-pain
#8
Keisuke Watanabe, Shigeki Hirano, Kazuho Kojima, Kengo Nagashima, Hiroki Mukai, Takatoshi Sato, Minoru Takemoto, Koji Matsumoto, Takashi Iimori, Sagiri Isose, Shigeki Omori, Kazumoto Shibuya, Yukari Sekiguchi, Minako Beppu, Hiroshi Amino, Tomoki Suichi, Koutaro Yokote, Takashi Uno, Satoshi Kuwabara, Sonoko Misawa
OBJECTIVE: To assess the cerebral blood flow (CBF) in patients with diabetic neuropathic pain, and its changes after duloxetine therapy. METHODS: Using iodine-123-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (IMP-SPECT), we performed a cross-sectional study of 44 patients with diabetes, and compared CBF in those with (n = 24) and without neuropathic pain (n = 20). In patients with neuropathic pain, we also longitudinally assessed changes in CBF 3 months after treatment with duloxetine...
April 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29623813/analysis-of-erythrocyte-membrane-proteins-in-patients-with-hereditary-spherocytosis-and-other-types-of-haemolytic-anaemia
#9
Atsushi Shibuya, Hiroaki Kawashima, Masato Tanaka
OBJECTIVES: In order to investigate the pathophysiology of erythrocyte membrane proteins, 10 patients (6 pre- and 4 post-splenectomy) with hereditary spherocytosis (HS) and other patients with haemolytic anaemia were examined. METHODS: The membrane proteins were analysed by biochemical and mass spectrometry. RESULTS: Reductions in the extracellular membrane of band 3 protein by eosin-5'-maleimide (EMA) binding test were greater in patients with pre-splenectomy HS than in patients with post-splenectomy HS, other types of haemolytic anaemia, and controls...
April 6, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29617393/cost-and-economic-burden-of-illness-over-15-years-in-nepal-a-comparative-analysis
#10
Khin Thet Swe, Md Mizanur Rahman, Md Shafiur Rahman, Eiko Saito, Sarah K Abe, Stuart Gilmour, Kenji Shibuya
BACKGROUND: With an increasing burden of non-communicable disease in Nepal and limited progress towards universal health coverage, country- and disease-specific estimates of financial hardship related to healthcare costs need to be evaluated to protect the population effectively from healthcare-related financial burden. OBJECTIVES: To estimate the cost and economic burden of illness and to assess the inequality in the financial burden due to catastrophic health expenditure from 1995 to 2010 in Nepal...
2018: PloS One
https://www.readbyqxmd.com/read/29607953/a-rare-case-of-ampullary-goblet-cell-carcinoid
#11
Hitoshi Shibuya, Susumu Hijioka, Nobumasa Mizuno, Takamichi Kuwahara, Nozomi Okuno, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Sachiyo Oonishi, Yoshiko Murakami, Yasushi Yatabe, Masahiro Tajika, Yasumasa Niwa, Kazuo Hara
An asymptomatic 70-year-old woman was referred to our hospital because of liver enzyme elevation. Enhanced abdominal computed tomography demonstrated a small, round-shaped tumor with dilation of the common bile duct (CBD) and main pancreatic duct (MPD). A biopsy specimen from the papilla showed mucin-containing cells that were positive for endocrine markers on immunohistochemical staining. Endoscopic snare resection was done, and there was a positive vertical margin on pathology. Pancreaticoduodenectomy was then performed later...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29607881/melanocytes-contribute-to-the-vasculature-of-the-choroid
#12
Hirotoshi Shibuya, Ryutaro Watanabe, Akiteru Maeno, Kaoru Ichimura, Masaru Tamura, Shigeharu Wakana, Toshihiko Shiroishi, Koji Ohba, Kazuhisa Takeda, Hiroshi Tomita, Shigeki Shibahara, Hiroaki Yamamoto
Melanocytes develop from the vertebrate embryo-specific neural crest, migrate, and localize in various organs, including not only the skin but also several extracutaneous locations such as the heart, inner ear and choroid. Little is known about the functions of extracutaneous melanocytes except for cochlear melanocytes, which are essential for hearing ability. In this study, we focused on the structure of the choroid, in which melanocytes are abundant around the well-developed blood vascular system. By comparing structural differences in the choroid of wild-type and melanocyte-deficient Mitfmi-bw /Mitfmi-bw mutant mice, our observations suggest that choroidal melanocytes contribute to the morphogenesis and/or maintenance of the normal vasculature structure of that tissue...
April 2, 2018: Genes & Genetic Systems
https://www.readbyqxmd.com/read/29597211/associations-between-pre-admission-risk-scores-and-two-year-clinical-outcomes-in-ischemic-stroke-or-transient-ischemic-attack-patients-with-non-valvular-atrial-fibrillation
#13
Keisuke Tokunaga, Hiroshi Yamagami, Masatoshi Koga, Kenichi Todo, Kazumi Kimura, Ryo Itabashi, Tadashi Terasaki, Yoshiaki Shiokawa, Kenji Kamiyama, Shunya Takizawa, Satoshi Okuda, Yasushi Okada, Tomoaki Kameda, Yoshinari Nagakane, Yasuhiro Hasegawa, Satoshi Shibuya, Yasuhiro Ito, Hideki Matsuoka, Kazuhiro Takamatsu, Kazutoshi Nishiyama, Kazuomi Kario, Yoshiki Yagita, Takanari Kitazono, Naoto Kinoshita, Junji Takasugi, Takuya Okata, Sohei Yoshimura, Shoichiro Sato, Shoji Arihiro, Kazunori Toyoda
BACKGROUND: We aimed to clarify associations between pre-admission risk scores (CHADS2, CHA2DS2-VASc, and HAS-BLED) and 2-year clinical outcomes in ischemic stroke or transient ischemic attack (TIA) patients with non-valvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry. METHODS: From 18 Japanese stroke centers, ischemic stroke or TIA patients with NVAF hospitalized within 7 days after onset were enrolled. Outcome measures were defined as death/disability (modified Rankin Scale score ≥3) at 2 years, 2-year mortality, and ischemic or hemorrhagic events within 2 years...
March 29, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29583036/the-ocular-involvement-did-not-accompany-with-the-genital-ulcer-or-the-gastrointestinal-symptoms-at-the-early-stage-of-beh%C3%A3-et-s-disease
#14
Akiko Suwa, Nobuyuki Horita, Takehito Ishido, Masaki Takeuchi, Tatsukata Kawagoe, Etsuko Shibuya, Takahiro Yamane, Takahiko Hayashi, Akira Meguro, Mizuho Ishido, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Shingo Kato, Jun Arimoto, Takeshi Fukumoto, Yoshiaki Ishigatsubo, Michiko Kurosawa, Takeshi Kaneko, Mitsuhiro Takeno, Nobuhisa Mizuki
OBJECTIVE: This study aimed to identify patients with high-probability of ocular involvement of Behçet's disease (BD). METHODS: The Japanese Ministry of Health, Labour and Welfare provided dataset of ongoing nationwide BD registration project. A patient who had confirmed BD and who was suspected to have BD were registered. We mainly analyzed newly registered patients who had the data for all of demographic and diagnostic parameters regardless of fulfilment of any diagnostic criteria...
March 27, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29558557/behavioral-counseling-for-skin-cancer-prevention-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#15
Nora B Henrikson, Caitlin C Morrison, Paula R Blasi, Matt Nguyen, Kendall C Shibuya, Carrie D Patnode
Importance: Exposure to UV radiation, especially in childhood, increases skin cancer risk. Objective: To systematically review the evidence on the benefits and harms of behavioral counseling for skin cancer prevention to inform the US Preventive Services Task Force (USPSTF). Data Sources: Cochrane Central Register of Controlled Trials, MEDLINE, and PubMed were searched for studies published from January 2009 to March 31, 2016, for skin cancer prevention and from August 2005 to March 31, 2016, for skin self-examination...
March 20, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29554580/ectopic-impulse-generation-in-peripheral-nerve-hyperexcitability-syndromes-and-amyotrophic-lateral-sclerosis
#16
Yu-Ichi Noto, Neil G Simon, Alexis Selby, Nidhi Garg, Kazumoto Shibuya, Nortina Shahrizaila, William Huynh, José M Matamala, Thanuja Dharmadasa, Susanna B Park, Steve Vucic, Matthew C Kiernan
OBJECTIVE: To elucidate differences in the distribution and firing frequency of fasciculations between peripheral nerve hyperexcitability syndromes and amyotrophic lateral sclerosis (ALS) and to explore the generator site of fasciculations. METHODS: Ultrasound of 14 preselected muscles was performed in patients with peripheral hyperexcitability and ALS. The distribution and firing frequency of fasciculations were calculated. Cortical excitability assessment was also done by threshold tracking transcranial magnetic stimulation...
February 10, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29515220/causes-and-risk-factors-for-singleton-stillbirth-in-japan-analysis-of-a-nationwide-perinatal-database-2013-2014
#17
Rei Haruyama, Stuart Gilmour, Erika Ota, Sarah K Abe, Md Mizanur Rahman, Shuhei Nomura, Naoyuki Miyasaka, Kenji Shibuya
Over 80% of perinatal mortality in Japan is due to stillbirths after 22 weeks of gestation, with one in 300 families experiencing fetal loss every year. This study aimed to assess causes and risk factors for singleton stillbirth in Japan. A retrospective cross-sectional study was conducted using the Japan Society of Obstetrics and Gynecology Perinatal Database from January 2013 to December 2014. A total of 379,211 births including 2,133 stillbirths were analyzed. Causes of death were classified into eight categories...
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29500747/welcoming-the-new-who-classification-of-pituitary-tumors-2017-revolution-in-ttf-1-positive-posterior-pituitary-tumors
#18
REVIEW
Makoto Shibuya
The fourth edition of the World Health Organization classification of endocrine tumors (EN-WHO2017) was released in 2017. In this new edition, changes in the classification of non-neuroendocrine tumors are proposed particularly in tumors arising in the posterior pituitary. These tumors are a distinct group of low-grade neoplasms of the sellar region that express thyroid transcription factor-1, and include pituicytoma, granular cell tumor of the sellar region, spindle cell oncocytoma, and sellar ependymoma. This short review focuses on the classification of posterior pituitary tumors newly proposed in EN-WHO2017, and controversies in their pathological differential diagnosis are discussed based on recent cases...
March 2, 2018: Brain Tumor Pathology
https://www.readbyqxmd.com/read/29494638/glycogen-synthase-kinase-3%C3%A3-functions-as-a-positive-effector-in-the-wnk-signaling-pathway
#19
Atsushi Sato, Hiroshi Shibuya
The with no lysine (WNK) protein kinase family is conserved among many species. Some mutations in human WNK gene are associated with pseudohypoaldosteronism type II, a form of hypertension, and hereditary sensory and autonomic neuropathy type 2A. In kidney, WNK regulates the activity of STE20/SPS1-related, proline alanine-rich kinase and/or oxidative-stress responsive 1, which in turn regulate ion co-transporters. The misregulation of this pathway is involved in the pathogenesis of pseudohypoaldosteronism type II...
2018: PloS One
https://www.readbyqxmd.com/read/29491338/-national-trends-in-the-distribution-of-candida-species-causing-candidemia-in-japan-from-2003-to-2014
#20
Hiroshi Kakeya, Koichi Yamada, Yukihiro Kaneko, Katsunori Yanagihara, Kazuhiro Tateda, Shigefumi Maesaki, Yoshio Takesue, Kazunori Tomono, Jun-Ichi Kadota, Mitsuo Kaku, Yoshitsugu Miyazaki, Katsuhiko Kamei, Kazutoshi Shibuya, Yoshitiho Niki, Minoru Yoshida, Yoshihiro Sei
The Epidemiological Investigation Committee for Human Mycoses in Japan performed a retrospective epidemiological survey of candidemia and causative Candida species. Data from 2003 to 2014 were collected from 10 Japanese university hospitals. A total of 328,318 blood cultures were included. The prevalence of fungi in all cultures and in positive cultures were 0.58±0.09% and 4.46±0.66%, respectively. Among the results that were positive for Candida species (N=1,921), Candida albicans was the most common species (39...
2018: Medical Mycology Journal
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