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https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#1
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28990871/cultural-adaptation-of-a-dyadic-intervention-for-korean-couples-coping-with-alzheimer-s-disease
#2
Minyoung Kwak, Jung-Hwa Ha, So-Yeon Hwang, Berit Ingersoll-Dayton, Beth Spencer
OBJECTIVES: The Couples Life Story Approach (CLSA) was recently reveloped in the U.S. for older couples dealing with dementia to improve their quality of life. The purpose of this article is to describe how the CLSA was adapted to be culturally appropriate for older Korean couples and to discuss cultural htemes that emerged during the implementation process. METHODS: The intervention was adapted using the Cultural Adaptation Process Model. The revised materials were implemented on 56 Korean couples...
August 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28982628/first-in-human-study-of-acoustic-angiography-in-the-breast-and-peripheral-vasculature
#3
Sarah E Shelton, Brooks D Lindsey, Paul A Dayton, Yueh Z Lee
Screening with mammography has been found to increase breast cancer survival rates by about 20%. However, the current system in which mammography is used to direct patients toward biopsy or surgical excision also results in relatively high rates of unnecessary biopsy, as 66.8% of biopsies are benign. A non-ionizing radiation imaging approach with increased specificity might reduce the rate of unnecessary biopsies. Quantifying the vascular characteristics within and surrounding lesions represents one potential target for assessing likelihood of malignancy via imaging...
October 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28972848/noticing-learners-strengths-through-cultural-research
#4
Barbara Rogoff, Andrew D Coppens, Lucía Alcalá, Itzel Aceves-Azuara, Omar Ruvalcaba, Angélica López, Andrew Dayton
Cultural research can help to identify strengths of cultural communities that are often viewed through a deficit model. Strengths-based approaches open researchers, practitioners, and the public to seeing the logic and value of cultural practices that vary from mainstream approaches. Strengths-based approaches include and extend beyond concerns for social equity: They are necessary for scientific characterization of human cognitive and social processes as well as for effective educational and societal practices...
September 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28962075/resilience-and-sustainability-similarities-and-differences-in-environmental-management-applications
#5
Dayton Marchese, Erin Reynolds, Matthew E Bates, Heather Morgan, Susan Spierre Clark, Igor Linkov
In recent years there have been many disparate uses of the terms sustainability and resilience, with some framing sustainability and resilience as the same concept, and others claiming them to be entirely different and unrelated. To investigate similarities, differences, and current management frameworks for increasing sustainability and resilience, a literature review was undertaken that focused on integrated use of sustainability and resilience in an environmental management context. Sustainability was defined through the triple bottom line of environmental, social and economic system considerations...
September 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28941396/real-time-ultrasound-angiography-using-superharmonic-dual-frequency-2-25mhz-30mhz-cylindrical-array-in-vitro-study
#6
Zhuochen Wang, K Heath Martin, Paul A Dayton, Xiaoning Jiang
Recent studies suggest that dual-frequency intravascular ultrasound (IVUS) transducers allow detection of superharmonic bubble signatures, enabling acoustic angiography for microvascular and molecular imaging. In this paper, a dual-frequency IVUS cylindrical array transducer was developed for real-time superharmonic imaging. A reduced form-factor lateral mode transmitter (2.25MHz) was used to excite microbubbles effectively at 782kPa with single-cycle excitation while still maintaining the small size and low profile (5Fr) (3Fr=1mm) for intravascular imaging applications...
September 15, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28898399/bias-corrected-estimation-of-the-rudas-clogg-lindsay-mixture-index-of-fit
#7
Jenő Reiczigel, Márton Ispány, Gábor Tusnády, György Michaletzky, Marco Marozzi
Rudas, Clogg, and Lindsay (1994, J. R Stat Soc. Ser. B, 56, 623) introduced the so-called mixture index of fit, also known as pi-star (π*), for quantifying the goodness of fit of a model. It is the lowest proportion of 'contamination' which, if removed from the population or from the sample, makes the fit of the model perfect. The mixture index of fit has been widely used in psychometric studies. We show that the asymptotic confidence limits proposed by Rudas et al. (1994, J. R Stat Soc. Ser. B, 56, 623) as well as the jackknife confidence interval by Dayton (, Br...
September 12, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28873246/multicriteria-decision-framework-for-cybersecurity-risk-assessment-and-management
#8
Alexander A Ganin, Phuoc Quach, Mahesh Panwar, Zachary A Collier, Jeffrey M Keisler, Dayton Marchese, Igor Linkov
Risk assessors and managers face many difficult challenges related to novel cyber systems. Among these challenges are the constantly changing nature of cyber systems caused by technical advances, their distribution across the physical, information, and sociocognitive domains, and the complex network structures often including thousands of nodes. Here, we review probabilistic and risk-based decision-making techniques applied to cyber systems and conclude that existing approaches typically do not address all components of the risk assessment triplet (threat, vulnerability, consequence) and lack the ability to integrate across multiple domains of cyber systems to provide guidance for enhancing cybersecurity...
September 5, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28872135/methods-and-tips-for-intravenous-administration-of-adeno-associated-virus-to-rats-and-evaluation-of-central-nervous-system-transduction
#9
Mychal S Grames, Kasey L Jackson, Robert D Dayton, John A Stanford, Ronald L Klein
Adeno-associated virus (AAV) vectors are a key reagent in the neurosciences for clustered regularly interspaced short palindromic repeats (CRISPR), optogenetics, cre-lox targeting, etc. The purpose of this manuscript is to aid the investigator attempting expansive central nervous system (CNS) gene transfer in the rat via tail vein injection of AAV. Wide-scale expression is relevant for conditions with widespread pathology, and a rat model is significant due to its greater size and physiologic similarities to humans compared to mice...
August 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28865858/farm-business-and-operator-variables-associated-with-bulk-tank-somatic-cell-count-from-dairy-herds-in-the-southeastern-united-states
#10
Karen L DeLong, Dayton M Lambert, Susan Schexnayder, Peter Krawczel, Mark Fly, Lorraine Garkovich, Steve Oliver
Mastitis is a worldwide problem in dairy cows and results in reduced milk production, the culling of cows, and other economic losses. Bulk tank somatic cell count (BTSCC) over 200,000 cells/mL often indicates underlying subclinical mastitis in dairy herds. Several preventative measures that can be implemented to help improve the incidence of mastitis exist, but surveys find these practices not fully adopted by producers. The goal of this research was to analyze the farm and operator characteristics associated with BTSCC in dairy herds by analyzing a survey of dairy producers in the southeastern United States...
November 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28863539/study-of-the-upper-critical-dimension-of-the-east-model-through-the-breakdown-of-the-stokes-einstein-relation
#11
Soree Kim, Dayton G Thorpe, Chanwoo Noh, Juan P Garrahan, David Chandler, YounJoon Jung
We investigate the dimensional dependence of dynamical fluctuations related to dynamic heterogeneity in supercooled liquid systems using kinetically constrained models. The d-dimensional spin-facilitated East model with embedded probe particles is used as a representative super-Arrhenius glass forming system. We examine the existence of an upper critical dimension in this model by considering decoupling of transport rates through an effective fractional Stokes-Einstein relation, D∼τ(-1+ω), with D and τ the diffusion constant of the probe particle and the relaxation time of the model liquid, respectively, and where ω>0 encodes the breakdown of the standard Stokes-Einstein relation...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28863270/mindfulness-based-forgiveness-groups-for-older-adults
#12
Mariko A Foulk, Berit Ingersoll-Dayton, James Fitzgerald
No abstract text is available yet for this article.
September 1, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28859050/overdose-deaths-related-to-fentanyl-and-its-analogs-ohio-january-february-2017
#13
Raminta Daniulaityte, Matthew P Juhascik, Kraig E Strayer, Ioana E Sizemore, Kent E Harshbarger, Heather M Antonides, Robert R Carlson
Ohio is experiencing unprecedented loss of life caused by unintentional drug overdoses (1), with illicitly manufactured fentanyl (IMF) emerging as a significant threat to public health (2,3). IMF is structurally similar to pharmaceutical fentanyl, but is produced in clandestine laboratories and includes fentanyl analogs that display wide variability in potency (2); variations in chemical composition of these drugs make detection more difficult. During 2010-2015, unintentional drug overdose deaths in Ohio increased 98%, from 1,544 to 3,050...
September 1, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28842090/comparison-of-tibial-sesamoid-position-on-anteroposterior-and-axial-radiographs-before-and-after-triplane-tarsal-metatarsal-joint-arthrodesis
#14
Paul Dayton, Mindi Feilmeier
We reviewed the radiographic results of a group of patients who had undergone triplane correctional tarsometatarsal arthrodesis for symptomatic hallux abducto valgus with metatarsus primus abducto valgus. Of the 21 feet included in the present review, 17 (81%) displayed radiographic findings of metatarsal pronation preoperatively based on axial sesamoid views and positive lateral round sign on anteroposterior radiographs. At a mean follow-up period of 5.2 ± 1.6 months, a significant improvement in the tibial sesamoid position (TSP) on both anteroposterior (AP) and axial radiographs was measured...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28842089/experimental-comparison-of-the-clinical-measurement-of-ankle-joint-dorsiflexion-and-radiographic-tibiotalar-position
#15
Paul Dayton, Mindi Feilmeier, Kalani Parker, Riane Otti, Rachel Reimer, Merrell Kauwe, Jake Eisenschink, Joshua Wolfe
Clinical measurement of ankle dorsiflexion is typically used to diagnose limited ankle range of motion. Controversy and a lack of clarity continue regarding the most accurate clinical method of measuring ankle joint dorsiflexion and the effect that the foot position (supinated, neutral, pronated) has on the true tibiotalar position. We investigated the effects of supinated, neutral and pronated foot positions on the clinical dorsiflexion measurements in 50 healthy subjects and compared these results to the radiographic measurement of tibiotalar joint position with the ankle maximally dorsiflexed in each of the 3 foot positions...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28793871/diagnostic-accuracy-of-contrast-enhanced-ultrasound-for-characterization-of-kidney-lesions-in-patients-with-and-without-chronic-kidney-disease
#16
Emily Hueywen Chang, Wui Kheong Chong, Sandeep Kumar Kasoji, Julia Rose Fielding, Ersan Altun, Lee B Mullin, Jung In Kim, Jason Peter Fine, Paul Alexander Dayton, Wendy Kimryn Rathmell
BACKGROUND: Patients with chronic kidney disease are at increased risk of cystic kidney disease that requires imaging monitoring in many cases. However, these same patients often have contraindications to contrast-enhanced computed tomography and magnetic resonance imaging. This study evaluates the accuracy of contrast-enhanced ultrasound (CEUS), which is safe for patients with chronic kidney disease, for the characterization of kidney lesions in patients with and without chronic kidney disease...
August 9, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28748462/in-vivo-rat-t-lymphocyte-pig-a-assay-detection-and-expansion-of-cells-deficient-in-the-gpi-anchored-cd48-surface-marker-for-analysis-of-mutation-in-the-endogenous-pig-a-gene
#17
Vasily N Dobrovolsky, Javier Revollo, Dayton M Petibone, Robert H Heflich
The Pig-a assay is being developed as an in vivo gene mutation assay for regulatory safety assessments. The assay is based on detecting mutation in the endogenous Pig-a gene of treated rats by using flow cytometry to measure changes in cell surface markers of peripheral blood cells. Here we present a methodology for demonstrating that phenotypically mutant rat T-cells identified by flow cytometry contain mutations in the Pig-a gene, an important step for validating the assay. In our approach, the mutant phenotype T-cells are sorted into individual wells of 96-well plates and expanded into clones...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735144/entorhinal-tau-pathology-disrupts-hippocampal-prefrontal-oscillatory-coupling-during-associative-learning
#18
Stephanie E Tanninen, Bardia Nouriziabari, Mark D Morrissey, Rami Bakir, Robert D Dayton, Ronald L Klein, Kaori Takehara-Nishiuchi
A neural signature of asymptomatic preclinical Alzheimer's disease (AD) is disrupted connectivity between brain regions; however, its underlying mechanisms remain unknown. Here, we tested whether a preclinical pathologic feature, tau aggregation in the entorhinal cortex (EC) is sufficient to disrupt the coordination of local field potentials (LFPs) between its efferent regions. P301L-mutant human tau or green fluorescent protein (GFP) was virally overexpressed in the EC of adult rats. LFPs were recorded from the dorsal hippocampus and prelimbic medial prefrontal cortex while the rats underwent trace eyeblink conditioning where they learned to associate 2 stimuli separated by a short time interval...
July 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28705744/the-relationship-between-ocular-trauma-and-substance-abuse-in-emergency-department-patients
#19
Sylvia L Chang, Vaama Patel, John Giltner, Richard Lee, Catherine A Marco
INTRODUCTION: Eye injury is the second most common cause of visual impairment and a leading cause of monocular blindness in the United States. There are approximately 6 million ED visits related to drug use annually, including misuse or abuse of pharmaceuticals and illicit drug use. The purpose of this study was to assess the relationship between ocular trauma and substance abuse among emergency department patients and to assess that relationship with demographic factors, including age and gender...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28668636/optimizing-sensitivity-of-ultrasound-contrast-enhanced-super-resolution-imaging-by-tailoring-size-distribution-of-microbubble-contrast-agent
#20
Fanglue Lin, James K Tsuruta, Juan D Rojas, Paul A Dayton
Ultrasound contrast-enhanced super-resolution imaging has recently attracted attention because of its extraordinary ability to image vascular features much smaller than the ultrasound diffraction limit. This method requires sensitive detection of separable microbubble events despite a noisy tissue background to indicate the microvasculature, and any approach that could improve the sensitivity of the ultrasound system to individual microbubbles would be highly beneficial. In this study, we evaluated the effect of varying microbubble size on super-resolution imaging sensitivity...
June 28, 2017: Ultrasound in Medicine & Biology
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