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https://www.readbyqxmd.com/read/28076378/p62-pathology-model-in-the-rat-substantia-nigra-with-filamentous-inclusions-and-progressive-neurodegeneration
#1
Kasey L Jackson, Wen-Lang Lin, Sumitra Miriyala, Robert D Dayton, Manikandan Panchatcharam, Kevin J McCarthy, Monica Castanedes-Casey, Dennis W Dickson, Ronald L Klein
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral sclerosis and inclusion body myositis. Since p62 functions in protein degradation pathways including autophagy, the build-up of p62-positive inclusions suggests defects in protein clearance. p62 was expressed unilaterally in the rat substantia nigra with an adeno-associated virus vector (AAV9) in order to study p62 neuropathology...
2017: PloS One
https://www.readbyqxmd.com/read/28073765/tracing-a-path-to-the-past-exploring-the-use-of-commercial-credit-reporting-data-to-construct-residential-histories-for-epidemiologic-studies-of-environmental-exposures
#2
Susan Hurley, Andrew Hertz, David O Nelson, Michael Layefsky, Julie Von Behren, Leslie Bernstein, Dennis Deapen, Peggy Reynolds
Large-scale environmental epidemiologic studies often rely on exposure estimates based on linkage to residential addresses. This approach, however, is limited by the lack of residential histories typically available for study participants. Our objective was to evaluate the feasibility of using address data from LexisNexis (a division of RELX, Inc., Dayton, Ohio), a commercially available credit reporting company, to construct residential histories for participants in the California Teachers Study (CTS), a prospective cohort study initiated in 1995-1996 to study breast cancer (n = 133,479)...
January 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28060237/a-comparison-of-matched-and-unmatched-orthopaedic-surgery-residency-applicants-from-2006-to-2014-data-from-the-national-resident-matching-program
#3
John B Schrock, Matthew J Kraeutler, Michael R Dayton, Eric C McCarty
BACKGROUND: The Association of American Medical Colleges publishes residency match data and reports through the National Resident Matching Program (NRMP) every year. The purpose of this study was to analyze trends in orthopaedic surgery residency matching data and characteristics of successful applicants to counsel medical students with regard to their chances of matching. METHODS: The annual reports of the NRMP were searched annually from 2006 to 2014 to determine the number of orthopaedic surgery residency positions available, the number of applicants, and the match rate among applicants...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28046261/we-fg-202-02-exploration-of-high-resolution-quantitative-ultrasonic-micro-vascular-imaging-for-early-assessment-of-radiotherapy-tumor-response
#4
S Kasoji, J Rivera, P Dayton, J Buse, S Chang
PURPOSE: Currently, we cannot predict an individual patient's response to a given radiotherapy which normally is not detected for weeks to months post-treatment. As a result, precious time is wasted for patients with unresponsive tumors who could have switched to an alternative treatment much earlier. Presently, no early treatment response detection method exists that is effective, low-cost, non-invasive, and safe. We hypothesize that changes in tumor microvasculature predict tumor response to radiotherapy earlier than tumor volume changes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042332/enhancing-nanoparticle-accumulation-and-retention-in-desmoplastic-tumors-via-vascular-disruption-for-internal-radiation-therapy
#5
Andrew B Satterlee, Juan D Rojas, Paul A Dayton, Leaf Huang
Aggressive, desmoplastic tumors are notoriously difficult to treat because of their extensive stroma, high interstitial pressure, and resistant tumor microenvironment. We have developed a combination therapy that can significantly slow the growth of large, stroma-rich tumors by causing massive apoptosis in the tumor center while simultaneously increasing nanoparticle uptake through a treatment-induced increase in the accumulation and retention of nanoparticles in the tumor. The vascular disrupting agent Combretastatin A-4 Phosphate (CA4P) is able to increase the accumulation of radiation-containing nanoparticles for internal radiation therapy, and the retention of these delivered radioisotopes is maintained over several days...
2017: Theranostics
https://www.readbyqxmd.com/read/28042327/3-d-ultrasound-localization-microscopy-for-identifying-microvascular-morphology-features-of-tumor-angiogenesis-at-a-resolution-beyond-the-diffraction-limit-of-conventional-ultrasound
#6
Fanglue Lin, Sarah E Shelton, David Espíndola, Juan D Rojas, Gianmarco Pinton, Paul A Dayton
Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet ultrasound has been limited in its ability to detect the microvascular changes associated with malignancy. Here, we demonstrate the potential of 'ultrasound localization microscopy' applied volumetrically in combination with quantitative analysis of microvascular morphology, as an approach to overcome this limitation. This pilot study demonstrates our ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe...
2017: Theranostics
https://www.readbyqxmd.com/read/28025076/unusual-extramedullary-hematopoietic-neoplasms-in-lymph-nodes
#7
Vanessa D Dayton, Sarah J Williams, Robert W McKenna, Michael A Linden
Myeloid, plasma cell, and lymphoblastic neoplasms are expected findings in bone marrow but are much less commonly diagnosed as primary processes in lymph nodes. The objective of this review is to aid pathologists in recognizing common hematopoietic neoplasms in the unusual setting of initial presentation in lymph nodes. Review of historical background and evolution of testing strategies is presented in order to improve understanding of the need for accurate diagnosis and classification using current nomenclature...
December 23, 2016: Human Pathology
https://www.readbyqxmd.com/read/28008310/corrigendum-better-targeting-better-efficiency-for-wide-scale-neuronal-transduction-with-the-synapsin-promoter-and-aav-php-b
#8
Kasey L Jackson, Robert D Dayton, Benjamin E Deverman, Ronald L Klein
[This corrects the article on p. 116 in vol. 9, PMID: 27867348.].
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28004406/development-and-socialization-of-physical-aggression-in-very-young-boys
#9
Carolyn Joy Dayton, Johanna C Malone
The expression of physical aggression is normative in early child development; it peaks in the second year of life, with steep declines for most children by the third and fourth years as children learn alternatives to aggression. Some children, however, fail to demonstrate declines in aggressive acts, and many of these are boys. The current review uses a dynamic systems (DS) approach to identify early individual and contextual factors that may dynamically influence trajectories of aggression as a characteristic way of engaging within communities and relationships...
January 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/27990585/vengeance-condomless-sex-and-hiv-disclosure-among-men-who-have-sex-with-men-living-with-hiv
#10
Monique J Brown, Julianne M Serovich, Judy A Kimberly, Jinxiang Hu
Vengeance has been shown to be a risk factor for HIV nondisclosure. Research examining the associations between vengeance, condomless sex, and HIV nondisclosure is lacking. The aim of the current study was to explore the association between vengeance, condomless sex and disclosure (behavior, attitude and intention) among men who have sex with men (MSM) living with HIV. Participants included 266 MSM who were a part of a disclosure intervention study. Men were recruited from local and state AIDS service organizations (ASOs), HIV-related venues and forums, and at local eating and drinking establishments in Tampa, Florida, and Columbus and Dayton, Ohio metropolitan statistical areas (MSAs)...
December 19, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27956109/practical-steps-to-integrate-family-voice-in-organization-policy-planning-and-decision-making-for-socio-emotional-trauma-informed-integrated-pediatric-care
#11
Lauren Dayton, Amelia Buttress, Jen Agosti, Javier Aceves, Meredith Kieschnick, Agatha Popejoy, Robyn Robbins, Kate Farinholt
This article explores barriers and strategies to achieving family-driven integrated child health care. Family involvement in health system design and reform has become a guiding principle in national and local efforts to improve children's mental health services. In practice, primary care clinicians, staff, and families continue to describe common barriers to integrating family voice. Drawing from the collective knowledge of the Pediatric Integrated Care Collaborative (PICC) and the National Alliance on Mental Illness (NAMI), we present strategies to overcome these barriers to successfully recruit, sustain, and expand family influence on health systems...
December 2016: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27940120/integrating-mental-and-physical-health-services-using-a-socio-emotional-trauma-lens
#12
Lauren Dayton, Jen Agosti, Deirdre Bernard-Pearl, Marian Earls, Kate Farinholt, Betsy McAlister Groves, Mark Rains, Barry Sarvet, Holly C Wilcox, Lawrence S Wissow
This article provides a synthesis of the lessons learned from the Pediatric Integrated Care Collaborative (PICC), a SAMHSA-funded project that is part of the National Child Traumatic Stress Network. The high prevalence of trauma exposure in childhood and shortage of mental health services has informed efforts to integrate mental and behavioral health services in pediatric primary care. This article outlines strategies to integrate care following the six goals of the PICC change framework: create a trauma/mental health informed office; involve families in program development; collaborate and coordinate with mental health services; promote resilience and prevent mental health problems through a particular focus on trauma-related risks; assess trauma-related somatic and mental health issues; and address trauma-related somatic and mental heath issues...
December 2016: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27939052/acoustic-behavior-of-a-reactivated-commercially-available-ultrasound-contrast-agent
#13
Songita A Choudhury, Feng Xie, Paul A Dayton, Thomas R Porter
BACKGROUND: Commercially available microbubbles such as Definity contain octafluoropropane encapsulated in a lipid shell. This perfluorocarbon can be compressed into liquid nanodroplets at room temperatures and activated with transthoracic diagnostic ultrasound. The aim of this study was to determine the size range and acoustic characteristics of Definity nanodroplets (DNDs) compared with Definity microbubbles (DMBs). METHODS: An in vitro flow system was used with a diagnostic ultrasound transducer (S5-1, iE33)...
December 6, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27910306/a-high-speed-two-frame-1-2-ns-gated-x-ray-cmos-imager-used-as-a-hohlraum-diagnostic-on-the-national-ignition-facility-invited
#14
Hui Chen, N Palmer, M Dayton, A Carpenter, M B Schneider, P M Bell, D K Bradley, L D Claus, L Fang, T Hilsabeck, M Hohenberger, O S Jones, J D Kilkenny, M W Kimmel, G Robertson, G Rochau, M O Sanchez, J W Stahoviak, D C Trotter, J L Porter
A novel x-ray imager, which takes time-resolved gated images along a single line-of-sight, has been successfully implemented at the National Ignition Facility (NIF). This Gated Laser Entrance Hole diagnostic, G-LEH, incorporates a high-speed multi-frame CMOS x-ray imager developed by Sandia National Laboratories to upgrade the existing Static X-ray Imager diagnostic at NIF. The new diagnostic is capable of capturing two laser-entrance-hole images per shot on its 1024 × 448 pixels photo-detector array, with integration times as short as 1...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27900541/tendon-transfer-to-unossified-bone-in-a-porcine-model-potential-implications-for-early-tibialis-anterior-tendon-transfers-in-children-with-clubfeet
#15
Matthew A Halanski, Sam Abrams, Rachel Lenhart, Ellen Leiferman, Teresa Kaiser, Emily Pierce, Rachel Rebekah Franklin, Dayton Opel, Kenneth J Noonan, Thomas D Crenshaw
PURPOSE: Tibialis anterior tendon transfers (TATT) are commonly performed in young children following Ponseti casting for clubfeet. The classic TATT involves advancing the tendon through a hole drilled in the ossified cuneiform. The aim of this study was to determine if tendons transferred through unossified bones have untoward effects on subsequent bone development. METHOD: Twenty-five piglets underwent one of five surgical procedures. An 18-gauge needle was then used to place a tunnel through the bony or cartilaginous portion of the calcaneus (through direct visualization) and isolated slips of the flexor digitorum superficialis (FDS) were placed through the tunnels, as determined by surgical procedure...
December 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27894558/helicopter-scene-response-for-stroke-patients-a-5-year-experience
#16
Andrew Hawk, Catherine Marco, Matt Huang, Bonnie Chow
OBJECTIVE: The purpose of this study was to examine the usefulness of an emergency medical service (EMS)-requested air medical helicopter response directly to the scene for a patient with clinical evidence of an ischemic cerebrovascular accident (CVA) and transport to a regional comprehensive CVA center. METHODS: CareFlight, an air medical critical care transportation service, is based in Dayton, OH. The 3 CareFlight helicopters are geographically located and provided transport to all CVA scene patients in this study...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27870047/a-keystone-ecologist-robert-treat-paine-1933-2016
#17
James A Estes, Paul K Dayton, Peter Kareiva, Simon A Levin, Jane Lubchenco, Bruce A Menge, Stephen R Palumbi, Mary E Power, John Terborgh
Robert T. Paine, who passed away on 13 June 2016, is among the most influential people in the history of ecology. Paine was an experimentalist, a theoretician, a practitioner, and proponent of the "ecology of place," and a deep believer in the importance of natural history to ecological understanding. His scientific legacy grew from the discovery of a link between top-down forcing and species diversity, a breakthrough that led to the ideas of both keystone species and trophic cascades, and to our early understanding of the mosaic nature of biological communities, causes of zonation across physical gradients, and the intermediate-disturbance hypothesis of species diversity...
November 2016: Ecology
https://www.readbyqxmd.com/read/27867348/better-targeting-better-efficiency-for-wide-scale-neuronal-transduction-with-the-synapsin-promoter-and-aav-php-b
#18
Kasey L Jackson, Robert D Dayton, Benjamin E Deverman, Ronald L Klein
Widespread genetic modification of cells in the central nervous system (CNS) with a viral vector has become possible and increasingly more efficient. We previously applied an AAV9 vector with the cytomegalovirus/chicken beta-actin (CBA) hybrid promoter and achieved wide-scale CNS transduction in neonatal and adult rats. However, this method transduces a variety of tissues in addition to the CNS. Thus we studied intravenous AAV9 gene transfer with a synapsin promoter to better target the neurons. We noted in systematic comparisons that the synapsin promoter drives lower level expression than does the CBA promoter...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27856534/pkm2-cancer-metabolism-and-the-road-ahead
#19
REVIEW
Talya L Dayton, Tyler Jacks, Matthew G Vander Heiden
A major metabolic aberration associated with cancer is a change in glucose metabolism. Isoform selection of the glycolytic enzyme pyruvate kinase has been implicated in the metabolic phenotype of cancer cells, and specific pyruvate kinase isoforms have been suggested to support divergent energetic and biosynthetic requirements of cells in tumors and normal tissues. PKM2 isoform expression has been closely linked to embryogenesis, tissue repair, and cancer. In contrast, forced expression of the PKM1 isoform has been associated with reduced tumor cell proliferation...
December 2016: EMBO Reports
https://www.readbyqxmd.com/read/27832421/high-resolution-ultrasound-superharmonic-perfusion-imaging-in-vivo-feasibility-and-quantification-of-dynamic-contrast-enhanced-acoustic-angiography
#20
Brooks D Lindsey, Sarah E Shelton, K Heath Martin, Kathryn A Ozgun, Juan D Rojas, F Stuart Foster, Paul A Dayton
Mapping blood perfusion quantitatively allows localization of abnormal physiology and can improve understanding of disease progression. Dynamic contrast-enhanced ultrasound is a low-cost, real-time technique for imaging perfusion dynamics with microbubble contrast agents. Previously, we have demonstrated another contrast agent-specific ultrasound imaging technique, acoustic angiography, which forms static anatomical images of the superharmonic signal produced by microbubbles. In this work, we seek to determine whether acoustic angiography can be utilized for high resolution perfusion imaging in vivo by examining the effect of acquisition rate on superharmonic imaging at low flow rates and demonstrating the feasibility of dynamic contrast-enhanced superharmonic perfusion imaging for the first time...
November 10, 2016: Annals of Biomedical Engineering
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