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https://www.readbyqxmd.com/read/29660939/aberrant-cortical-event-related-potentials-during-associative-learning-in-rat-models-for-presymptomatic-stages-of-alzheimer-s-disease
#1
Bardia Nouriziabari, Susmita Sarkar, Stephanie E Tanninen, Robert D Dayton, Ronald L Klein, Kaori Takehara-Nishiuchi
Trace eyeblink conditioning is a hippocampus-dependent associative learning paradigm which is impaired in patients with Alzheimer's disease (AD) and animal AD models. Learning in this paradigm accompanies changes in oscillatory activity in forebrain regions, some of which are loci of pathogenic changes in prodromal AD stages. These observations motivated us to examine how cortical event-related potentials (ERPs) during this paradigm are affected by two features of the asymptomatic, AD-related brain abnormality, entorhinal tau accumulation and mild cholinergic deficit...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29658277/cavitation-enhancement-increases-the-efficiency-and-consistency-of-chromatin-fragmentation-from-fixed-cells-for-downstream-quantitative-applications
#2
Anna M Chiarella, Austin L Quimby, Marjan Mehrab-Mohseni, Brian Velasco, Sandeep K Kasoji, Ian Davis, Paul A Dayton, Nathaniel A Hathaway, Samantha Pattenden
One of the most sensitive, time consuming, and variable steps of chromatin immunoprecipitation (ChIP) is chromatin sonication. Traditionally, this process can take hours to properly sonicate enough chromatin for multiple ChIP assays. Further, the length of sheared DNA is often inconsistent. In order to faithfully measure chemical and structural changes at the chromatin level, sonication needs to be reliable. Thus, chromatin fragmentation by sonication represents a significant bottleneck to downstream quantitative analysis...
April 16, 2018: Biochemistry
https://www.readbyqxmd.com/read/29616324/variability-in-circulating-gas-emboli-after-a-same-scuba-diving-exposure
#3
V Papadopoulou, P Germonpré, D Cosgrove, R J Eckersley, P A Dayton, G Obeid, A Boutros, M-X Tang, S Theunissen, C Balestra
PURPOSE: A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which is mitigated by adherence to decompression schedules; however, bubbles are routinely observed for dives well within these limits and significant inter-personal variability in DCS risk exists. Here, we assess the variability and evolution of VGE for 2 h post-dive using echocardiography, following a standardized pool dive in calm warm conditions...
April 3, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29602746/an-appointment-based-model-to-systematically-assess-and-administer-vaccinations
#4
Heidi R Luder, Natalie Kunze, Pamela C Heaton, Stacey M Frede
OBJECTIVES: To incorporate the assessment of vaccination status and administration of vaccines in an appointment-based model (ABM) and measure the impact on vaccinations administered and patient and pharmacist satisfaction with the appointment-based model. PRACTICE DESCRIPTION: An ABM was implemented to systematically assess vaccination status and administer vaccines. Patients made an appointment to pick up synchronized prescriptions, and pharmacists assessed vaccination histories and administered vaccinations during the appointment...
March 27, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29602540/accelerated-clearance-of-ultrasound-contrast-agents-containing-polyethylene-glycol-is-associated-with-the-generation-of-anti-polyethylene-glycol-antibodies
#5
Samantha M Fix, A Gloria Nyankima, Morgan D McSweeney, James K Tsuruta, Samuel K Lai, Paul A Dayton
Emerging evidence suggests that the immune system can recognize polyethylene glycol (PEG), leading to the accelerated blood clearance (ABC) of PEGylated particles. Our aim here was to study the generation of anti-PEG immunity and changes in PEGylated microbubble pharmacokinetics during repeated contrast-enhanced ultrasound imaging in rats. We administered homemade PEGylated microbubbles multiple times over a 28-d period and observed dramatically accelerated clearance (4.2 × reduction in half-life), which was associated with robust anti-PEG IgM and anti-PEG IgG antibody production...
March 27, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29602296/transcriptomic-analysis-reveals-inflammatory-and-metabolic-pathways-which-are-regulated-by-renal-perfusion-pressure-in-the-outer-medulla-of-dahl-s-rats
#6
Louise C Evans, Alex Dayton, Chun Yang, Pengyuan Liu, Theresa Kurth, Kwang Woo Ahn, Steve Komas, Francesco C Stingo, Purushottam W Laud, Marina Vannucci, Mingyu Liang, Allen W Cowley
Studies exploring the development of hypertension have traditionally been unable to distinguish which of the observed changes are underlying causes from those which are a consequence of elevated blood pressure. In this study, a custom designed servo-control system was utilized to precisely control renal perfusion pressure to the left kidney continuously during the development of hypertension in Dahl salt-sensitive rats. In this way, we maintained the left kidney at control blood pressure while the right kidney was exposed to hypertensive pressures...
March 30, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29597145/collaboration-or-negotiation-two-ways-of-interacting-suggest-how-shared-thinking-develops
#7
REVIEW
Rebeca Mejía-Arauz, Barbara Rogoff, Andrew Dayton, Richard Henne-Ochoa
This paper contrasts two ways that shared thinking can be conceptualized: as negotiation, where individuals join their separate ideas, or collaboration, as people mutually engage together in a unified process, as an ensemble. We argue that these paradigms are culturally based, with the negotiation model fitting within an assumption system of separate entities-an assumption system we believe to be common in psychology and in middle-class European American society-and the collaboration model fitting within a holistic worldview that appears to be common in Indigenous-heritage communities of the Americas...
March 9, 2018: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29592995/a-rare-case-of-pyogenic-pericarditis-secondary-to-streptococcus-constellatus
#8
Sehem Ghazala, Todd Rabkin Golden, Sumaya Farran, Tirdad T Zangeneh
We report an extremely rare case of purulent pericarditis caused by the normally commensal oral flora, Streptococcus constellatus, a viridans Streptococcal species and member of the S. anginosus group (previously also known by the eponymous ' S. milleri', for American Willoughby Dayton Miller). This case is a previously healthy 71-year-old immunocompetent woman from Arizona who presented with a 5-day history of progressive shortness of breath and chest tightness, and subjective fever and chills, but without history of nausea, vomiting, night sweats, recent travel, autoimmune disease or sick contacts...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29548719/bioequivalence-of-dapagliflozin-metformin-extended-release-fixed-combination-drug-product-and-single-component-dapagliflozin-and-metformin-extended-release-tablets-in-healthy-russian-subjects
#9
Yunona Khomitskaya, Nadezhda Tikhonova, Konstantin Gudkov, Svetlana Erofeeva, Victoria Holmes, Brian Dayton, Nigel Davies, David W Boulton, Weifeng Tang
PURPOSE: Fixed-combination drug products (FCDPs) combining dapagliflozin and metformin extended release (XR) may provide patients with type 2 diabetes mellitus with an alternative antihyperglycemic treatment, which could improve adherence by reducing tablet burden. This study evaluated the bioequivalence of dapagliflozin/metformin XR FCDP versus the co-administration of the individual monotherapy tablets currently available for use in the Russian Federation. METHODS: Healthy subjects aged 18 to 45 years were enrolled in this randomized, open-label, 2-period crossover study, conducted in a single Russian center...
March 13, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29545601/tdp43-nuclear-export-and-neurodegeneration-in-models-of-amyotrophic-lateral-sclerosis-and-frontotemporal-dementia
#10
Hilary C Archbold, Kasey L Jackson, Ayush Arora, Kaitlin Weskamp, Elizabeth M-H Tank, Xingli Li, Roberto Miguez, Robert D Dayton, Sharon Tamir, Ronald L Klein, Sami J Barmada
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative disorders marked in most cases by the nuclear exclusion and cytoplasmic deposition of the RNA binding protein TDP43. We previously demonstrated that ALS-associated mutant TDP43 accumulates within the cytoplasm, and that TDP43 mislocalization predicts neurodegeneration. Here, we sought to prevent neurodegeneration in ALS/FTD models using selective inhibitor of nuclear export (SINE) compounds that target exportin-1 (XPO1)...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29534815/conscious-sedation-versus-rapid-sequence-intubation-for-the-reduction-of-native-traumatic-hip-dislocation
#11
Aravind K Bommiasamy, Dayton Opel, Raluca McCallum, John D Yonge, Vicente Undurraga Perl, Christopher R Connelly, Darin Friess, Martin A Schreiber, Richard J Mullins
BACKGROUND: Traumatic hip dislocations (THD) are a medical emergency. There is debate whether the painful reduction of a dislocated hip should be first attempted using primary conscious sedation (PCS) or primary general anesthesia (PGA) METHODS: All cases of native THD from 2006 to 2015 in the trauma registry of a level 1 trauma center were reviewed. The primary outcome was successful reduction of the THD. RESULTS: 67 patients had a native, meaning not a hip prosthesis, THD...
February 27, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29526358/patients-with-anomalous-aortic-origin-of-the-coronary-artery-remain-at-risk-after-surgical-repair
#12
Shannon N Nees, Jonathan N Flyer, Anjali Chelliah, Jeffrey D Dayton, Lorraine Touchette, David Kalfa, Paul J Chai, Emile A Bacha, Brett R Anderson
OBJECTIVES: Anomalous aortic origin of a coronary artery (AAOCA) from the opposite sinus of Valsalva is a rare cardiac anomaly associated with sudden cardiac death (SCD). Single-center studies describe surgical repair as safe, although medium- and long-term effects on symptoms and risk of SCD remain unknown. We sought to describe outcomes of surgical repair of AAOCA. METHODS: We reviewed institutional records for patients who underwent AAOCA repair, from 2001 to 2016, at 2 affiliated institutions...
February 8, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29513569/cre-dependent-aav-vectors-for-highly-targeted-expression-of-disease-related-proteins-and-neurodegeneration-in-the-substantia-nigra
#13
Mychal S Grames, Robert D Dayton, Kasey L Jackson, Adam D Richard, Xiaohong Lu, Ronald L Klein
Recombinant adeno-associated virus (AAV) vectors are a popular genetic approach in neuroscience because they confer such efficient transgene expression in the brain and spinal cord. A number of studies have used AAV to express pathological disease-related proteins in the dopaminergic neurons of the substantia nigra in situ ( e.g., α-synuclein to model aspects of Parkinson's disease). The neuropathology and neurodegeneration of Parkinson's disease occur in a circumscribed pattern in the brain, and one of the most important goals of any gene transfer study is accurate, pinpoint targeting...
March 7, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29508011/imaging-with-ultrasound-contrast-agents-current-status-and-future
#14
REVIEW
Wui K Chong, Virginie Papadopoulou, Paul A Dayton
Microbubble ultrasound contrast agents (UCAs) were recently approved by the Food and Drug administration for non-cardiac imaging. The physical principles of UCAs, methods of administration, dosage, adverse effects, and imaging techniques both current and future are described. UCAs consist of microbubbles in suspension which strongly interact with the ultrasound beam and are readily detectable by ultrasound imaging systems. They are confined to the blood pool when administered intravenously, unlike iodinated and gadolinium contrast agents...
March 5, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29501754/involvement-of-adenosine-monophosphate-activated-kinase-in-interleukin-6-regulation-of-steroidogenic-acute-regulatory-protein-and-cholesterol-side-chain-cleavage-enzyme-in-the-bovine-zona-fasciculata-and-zona-reticularis
#15
Matharage S I De Silva, Adam W Dayton, Lance R Rhoten, John W Mallett, Jared C Reese, Mathieu D Squires, Andrew P Dalley, James P Porter, Allan M Judd
In bovine adrenal zona fasciculata (ZF) and NCI-H295R cells, interleukin-6 (IL-6) increases cortisol release, increases expression of steroidogenic acute regulatory protein (StAR), cholesterol side chain cleavage enzyme (P450scc), and steroidogenic factor 1 (SF-1) (increases steroidogenic proteins), and decreases the expression of adrenal hypoplasia congenita-like protein (DAX-1) (inhibits steroidogenic proteins). In contrast, IL-6 decreases bovine adrenal zona reticularis (ZR) androgen release, StAR, P450scc, and SF-1 expression, and increases DAX-1 expression...
March 1, 2018: Steroids
https://www.readbyqxmd.com/read/29464967/the-familias-saludables-partnership-engaging-the-latino-community-to-address-early-childhood-obesity
#16
Darcy A Thompson, Deborah A Federspiel
Darcy A Thompson is an Associate Professor of pediatrics at the University of Colorado School of Medicine. Her main research seeks to address early childhood obesity in low-income children. She works in the Lifestyle Medicine clinic at Children's Hospital Colorado, a clinic focused on caring for children with obesity and related comorbidities. She is also an Associate Medical Director for the Research Institute at Children's Hospital Colorado. Her training includes a Master of Public Health degree, a medical degree (Yale University) and the Robert Wood Johnson Clinical Scholars Fellowship (University of Washington)...
February 21, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29399650/lc-ms-ms-based-method-for-the-multiplex-detection-of-24-fentanyl-analogues-and-metabolites-in-whole-blood-at-sub-ng-ml-1-concentrations
#17
Kraig E Strayer, Heather M Antonides, Matthew P Juhascik, Raminta Daniulaityte, Ioana E Sizemore
The United States and numerous other countries worldwide are currently experiencing a public health crisis due to the abuse of illicitly manufactured fentanyl (IMF) and its analogues. This manuscript describes the development of a liquid chromatography-tandem mass spectrometry-based method for the multiplex detection of N = 24 IMF analogues and metabolites in whole blood at concentrations as low as 0.1-0.5 ng mL-1. These available IMFs were fentanyl, norfentanyl, furanyl norfentanyl, remifentanil acid, butyryl norfentanyl, remifentanil, acetyl fentanyl, alfentanil, AH-7921, U-47700, acetyl fentanyl 4-methylphenethyl, acrylfentanyl, para-methoxyfentanyl, despropionyl fentanyl (4-ANPP), furanyl fentanyl, despropionyl para-fluorofentanyl, carfentanil, (±)-cis-3-methyl fentanyl, butyryl fentanyl, isobutyryl fentanyl, sufentanil, valeryl fentanyl, para-fluorobutyryl fentanyl, and para-fluoroisobutyryl fentanyl...
January 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/29373606/modulation-of-hiv-replication-in-monocyte-derived-macrophages-mdm-by-steroid-hormones
#18
Krishnakumar Devadas, Santanu Biswas, Viswanath Ragupathy, Sherwin Lee, Andrew Dayton, Indira Hewlett
Significant sex specific differences in the progression of HIV/AIDS have been reported. Several studies have implicated steroid hormones in regulating host factor expression and modulating HIV transmission and replication. However, the exact mechanism exerted by steroid hormones estrogen and progesterone in the regulation of HIV-1 replication is still unclear. Results from the current study indicated a dose dependent down regulation of HIV-1 replication in monocyte derived macrophages pre-treated with high concentrations of estrogen or progesterone...
2018: PloS One
https://www.readbyqxmd.com/read/29322935/classifying-cancer-genome-aberrations-by-their-mutually-exclusive-effects-on-transcription
#19
Jonathan B Dayton, Stephen R Piccolo
BACKGROUND: Malignant tumors are typically caused by a conglomeration of genomic aberrations-including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug treatments are effective against tumors that harbor certain genomic aberrations. However, predictive aberrations (biomarkers) have not been identified for many tumor types and treatments. One way to address this problem is to examine the downstream, transcriptional effects of genomic aberrations and to identify characteristic patterns...
December 21, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29306336/effectiveness-of-echocardiography-simulation-training-for-paediatric-cardiology-fellows-in-chd
#20
Jeffrey D Dayton, Alan M Groves, Julie S Glickstein, Patrick A Flynn
Simulation is used in many aspects of medical training but less so for echocardiography instruction in paediatric cardiology. We report our experience with the introduction of simulator-based echocardiography training at Weill Cornell Medicine for paediatric cardiology fellows of the New York-Presbyterian Hospital of Columbia University and Weill Cornell Medicine. Knowledge of CHD and echocardiographic performance improved following simulation-based training. Simulator training in echocardiography can be an effective addition to standard training for paediatric cardiology trainees...
April 2018: Cardiology in the Young
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