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https://www.readbyqxmd.com/read/29214019/pkm2-is-not-required-for-colon-cancer-initiated-by-apc-loss
#1
Allison N Lau, William J Israelsen, Jatin Roper, Mark J Sinnamon, Larissa Georgeon, Talya L Dayton, Alissandra L Hillis, Omer H Yilmaz, Dolores Di Vizio, Kenneth E Hung, Matthew G Vander Heiden
Background: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic role in β-catenin nuclear translocation. PKM2 is expressed in colon cancers where loss of the Apc tumor suppressor results in β-catenin nuclear translocation and aberrant activation of the canonical Wnt signaling pathway...
2017: Cancer & Metabolism
https://www.readbyqxmd.com/read/29196604/camkii-regulates-the-de-palmitoylation-and-synaptic-removal-of-akap79-150-to-mediate-structural-ltd
#2
Kevin M Woolfrey, Heather O'Leary, Dayton J Goodell, Holly R Robertson, Eric A Horne, Steven J Coultrap, Mark L Dell'Acqua, K Ulrich Bayer
Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by T286 autophosphorylation. Additionally, LTP and LTD are correlated with dendritic spine enlargement and shrinkage that are accompanied by the synaptic accumulation or removal, respectively, of the AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/150. We show here that the spine shrinkage associated with LTD indeed requires synaptic AKAP79/150 removal, which in turn requires CaMKII activity...
December 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29156165/understanding-frontal-plane-correction-in-hallux-valgus-repair
#3
REVIEW
W Bret Smith, Paul Dayton, Robert D Santrock, Daniel J Hatch
Hallux-abducto-valgus or "bunion" surgery is one of the most common surgical procedures for the foot and ankle specialist. As our understanding of the hallux-abducto-valgus deformity has grown, it is becoming clear that the anatomic CORA of the deformity may lie at the tarsometatarsal joint. There is also the component of the 3-dimensional nature of the deformity that may be best addressed at this CORA. With these issues in mind, it was necessary to address the shortcomings of the traditional Lapidus procedure and progress toward more consistent, instrumented steps that could address the 3-dimensional nature of the deformity...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29153853/community-pharmacist-collaboration-with-a-patient-centered-medical-home-establishment-of-a-patient-centered-medical-neighborhood-and-payment-model
#4
Heidi R Luder, Pam Shannon, James Kirby, Stacey M Frede
OBJECTIVES: To determine the feasibility of a partnership between a community pharmacy and a patient-centered medical home (PCMH) by measuring the impact on office- and patient-level clinical outcomes. SETTING: Kroger Pharmacy and a PCMH practice in Cincinnati, OH. PRACTICE DESCRIPTION: The Kroger Co. is a large grocery store chain that operates 102 pharmacies in the Cincinnati-Dayton marketing area. The PCMH practice is an accredited PCMH office serving more than 9000 patients in the Cincinnati area...
November 15, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29140404/evaluation-of-opportunities-to-improve-hematopathology-diagnosis-for-vietnam-pathologists
#5
Vanessa Dayton, Chi Kim Nguyen, Trinh Thu Van, Nguyen Van Thanh, Ta Van To, Nguyen Phi Hung, Nguyen Ngoc Dung, Danny A Milner
Objectives: We evaluate the need for, feasibility of, and impediments to improving hematopathology diagnoses for cancer hospitals in Vietnam. Methods: Two hematopathologists from the United States visited three major cancer treatment hospitals in Vietnam to workshop a sampling of difficult hematopathology cases. With Vietnamese pathologists, they toured histopathology, immunohistochemistry, and ancillary laboratory facilities. Results: Automated tissue processors and slide staining equipment were documented for each of the three hospitals...
November 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29133343/clinical-and-histologic-characterization-of-nonalcoholic-steatohepatitis-in-african-american-patients
#6
Fernando Bril, Paola Portillo-Sanchez, I-Chia Liu, Srilaxmi Kalavalapalli, Kristin Dayton, Kenneth Cusi
OBJECTIVE: There has been a widespread misconception among physicians that African Americans are protected from developing nonalcoholic steatohepatitis (NASH). However, a formal histologic and metabolic comparison against well-matched Caucasians has never been performed. RESEARCH DESIGN AND METHODS: Sixty-seven African American patients were matched 2:1 to Caucasians (n = 134) for age, sex, BMI, hemoglobin A1c, and prevalence of type 2 diabetes mellitus (T2DM). Screening for NASH included measurement of intrahepatic triglyceride content by proton MRS ((1)H-MRS), followed by a liver biopsy if patients had hepatic steatosis...
November 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29096546/memory-keeper-a-prototype-digital-application-to-improve-engagement-with-people-with-dementia-in-long-term-care-innovative-practice
#7
Margaret McAllister, Jeanne Dayton, Florin Oprescu, Mary Katsikitis, Christian M Jones
People with dementia living in long-term care commonly experience loneliness and lack of meaningful activity. Memory Keeper is a prototype digital application that presents personalised prompts to stimulate reminiscences and meaningful engagement with formal and informal carers. A trial involving three persons with dementia in long-term care and seven family and staff members revealed no negative responses to the device or application. Family members said it was valuable in improving the quality of engagement and made visits more enjoyable...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29076807/photon-management-in-supramolecular-peptide-nanomaterials
#8
John Dayton Tovar
Self-assembling peptides with covalent pi-electron functionality offer new ways to create delocalized conduits within protein-based nanomaterials. Our recent research is summarized in this regard, detailing foundational self-assembly and photophysical characterizations that validate the electronic couplings existing within the resulting peptidic nanomaterials. Using these initial studies as a benchmark, ongoing studies to create even more complex photonic energy delocalization schemes are presented, spanning excitonic and Förster energy transfer to low-bandgap dopant sites (whereby 46% of the observed photoluminescence could be quenched by the addition of 1 mol% of an energy acceptor), the creation of charge separated states following photoinduced electron transfer that persisted for over a nanosecond, and use of kinetic control to dictate self-sorting (at long time scales, ca...
October 27, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#9
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28990871/cultural-adaptation-of-a-dyadic-intervention-for-korean-couples-coping-with-alzheimer-s-disease
#10
Minyoung Kwak, Jung-Hwa Ha, So-Yeon Hwang, Berit Ingersoll-Dayton, Beth Spencer
OBJECTIVES: The Couples Life Story Approach (CLSA) was recently reveloped in the U.S. for older couples dealing with dementia to improve their quality of life. The purpose of this article is to describe how the CLSA was adapted to be culturally appropriate for older Korean couples and to discuss cultural htemes that emerged during the implementation process. METHODS: The intervention was adapted using the Cultural Adaptation Process Model. The revised materials were implemented on 56 Korean couples...
August 16, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28982628/first-in-human-study-of-acoustic-angiography-in-the-breast-and-peripheral-vasculature
#11
Sarah E Shelton, Brooks D Lindsey, Paul A Dayton, Yueh Z Lee
Screening with mammography has been found to increase breast cancer survival rates by about 20%. However, the current system in which mammography is used to direct patients toward biopsy or surgical excision also results in relatively high rates of unnecessary biopsy, as 66.8% of biopsies are benign. A non-ionizing radiation imaging approach with increased specificity might reduce the rate of unnecessary biopsies. Quantifying the vascular characteristics within and surrounding lesions represents one potential target for assessing likelihood of malignancy via imaging...
October 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28972848/noticing-learners-strengths-through-cultural-research
#12
Barbara Rogoff, Andrew D Coppens, Lucía Alcalá, Itzel Aceves-Azuara, Omar Ruvalcaba, Angélica López, Andrew Dayton
Cultural research can help to identify strengths of cultural communities that are often viewed through a deficit model. Strengths-based approaches open researchers, practitioners, and the public to seeing the logic and value of cultural practices that vary from mainstream approaches. Strengths-based approaches include and extend beyond concerns for social equity: They are necessary for scientific characterization of human cognitive and social processes as well as for effective educational and societal practices...
September 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28962075/resilience-and-sustainability-similarities-and-differences-in-environmental-management-applications
#13
Dayton Marchese, Erin Reynolds, Matthew E Bates, Heather Morgan, Susan Spierre Clark, Igor Linkov
In recent years there have been many disparate uses of the terms sustainability and resilience, with some framing sustainability and resilience as the same concept, and others claiming them to be entirely different and unrelated. To investigate similarities, differences, and current management frameworks for increasing sustainability and resilience, a literature review was undertaken that focused on integrated use of sustainability and resilience in an environmental management context. Sustainability was defined through the triple bottom line of environmental, social and economic system considerations...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28941396/real-time-ultrasound-angiography-using-superharmonic-dual-frequency-2-25mhz-30mhz-cylindrical-array-in-vitro-study
#14
Zhuochen Wang, K Heath Martin, Paul A Dayton, Xiaoning Jiang
Recent studies suggest that dual-frequency intravascular ultrasound (IVUS) transducers allow detection of superharmonic bubble signatures, enabling acoustic angiography for microvascular and molecular imaging. In this paper, a dual-frequency IVUS cylindrical array transducer was developed for real-time superharmonic imaging. A reduced form-factor lateral mode transmitter (2.25MHz) was used to excite microbubbles effectively at 782kPa with single-cycle excitation while still maintaining the small size and low profile (5Fr) (3Fr=1mm) for intravascular imaging applications...
January 2018: Ultrasonics
https://www.readbyqxmd.com/read/28898399/bias-corrected-estimation-of-the-rudas-clogg-lindsay-mixture-index-of-fit
#15
Jenő Reiczigel, Márton Ispány, Gábor Tusnády, György Michaletzky, Marco Marozzi
Rudas, Clogg, and Lindsay (1994, J. R Stat Soc. Ser. B, 56, 623) introduced the so-called mixture index of fit, also known as pi-star (π*), for quantifying the goodness of fit of a model. It is the lowest proportion of 'contamination' which, if removed from the population or from the sample, makes the fit of the model perfect. The mixture index of fit has been widely used in psychometric studies. We show that the asymptotic confidence limits proposed by Rudas et al. (1994, J. R Stat Soc. Ser. B, 56, 623) as well as the jackknife confidence interval by Dayton (, Br...
September 12, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28873246/multicriteria-decision-framework-for-cybersecurity-risk-assessment-and-management
#16
Alexander A Ganin, Phuoc Quach, Mahesh Panwar, Zachary A Collier, Jeffrey M Keisler, Dayton Marchese, Igor Linkov
Risk assessors and managers face many difficult challenges related to novel cyber systems. Among these challenges are the constantly changing nature of cyber systems caused by technical advances, their distribution across the physical, information, and sociocognitive domains, and the complex network structures often including thousands of nodes. Here, we review probabilistic and risk-based decision-making techniques applied to cyber systems and conclude that existing approaches typically do not address all components of the risk assessment triplet (threat, vulnerability, consequence) and lack the ability to integrate across multiple domains of cyber systems to provide guidance for enhancing cybersecurity...
September 5, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28872135/methods-and-tips-for-intravenous-administration-of-adeno-associated-virus-to-rats-and-evaluation-of-central-nervous-system-transduction
#17
Mychal S Grames, Kasey L Jackson, Robert D Dayton, John A Stanford, Ronald L Klein
Adeno-associated virus (AAV) vectors are a key reagent in the neurosciences for clustered regularly interspaced short palindromic repeats (CRISPR), optogenetics, cre-lox targeting, etc. The purpose of this manuscript is to aid the investigator attempting expansive central nervous system (CNS) gene transfer in the rat via tail vein injection of AAV. Wide-scale expression is relevant for conditions with widespread pathology, and a rat model is significant due to its greater size and physiologic similarities to humans compared to mice...
August 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28865858/farm-business-and-operator-variables-associated-with-bulk-tank-somatic-cell-count-from-dairy-herds-in-the-southeastern-united-states
#18
Karen L DeLong, Dayton M Lambert, Susan Schexnayder, Peter Krawczel, Mark Fly, Lorraine Garkovich, Steve Oliver
Mastitis is a worldwide problem in dairy cows and results in reduced milk production, the culling of cows, and other economic losses. Bulk tank somatic cell count (BTSCC) over 200,000 cells/mL often indicates underlying subclinical mastitis in dairy herds. Several preventative measures that can be implemented to help improve the incidence of mastitis exist, but surveys find these practices not fully adopted by producers. The goal of this research was to analyze the farm and operator characteristics associated with BTSCC in dairy herds by analyzing a survey of dairy producers in the southeastern United States...
November 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28863539/study-of-the-upper-critical-dimension-of-the-east-model-through-the-breakdown-of-the-stokes-einstein-relation
#19
Soree Kim, Dayton G Thorpe, Chanwoo Noh, Juan P Garrahan, David Chandler, YounJoon Jung
We investigate the dimensional dependence of dynamical fluctuations related to dynamic heterogeneity in supercooled liquid systems using kinetically constrained models. The d-dimensional spin-facilitated East model with embedded probe particles is used as a representative super-Arrhenius glass forming system. We examine the existence of an upper critical dimension in this model by considering decoupling of transport rates through an effective fractional Stokes-Einstein relation, D∼τ(-1+ω), with D and τ the diffusion constant of the probe particle and the relaxation time of the model liquid, respectively, and where ω>0 encodes the breakdown of the standard Stokes-Einstein relation...
August 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28863270/mindfulness-based-forgiveness-groups-for-older-adults
#20
Mariko A Foulk, Berit Ingersoll-Dayton, James Fitzgerald
Interventions that enable individuals to be more forgiving toward themselves and others are important for older adults. This article describes a group intervention for adults aged 60 or older that integrates forgiveness-related skills with a mindfulness approach. The Mindfulness-based Forgiveness Group was designed to meet for eight sessions. The skills taught included: recognizing one's own expectations and unenforceable rules, broadening one's perspectives about the context of the transgression, and discovering positive intentions through exercises as well as a variety of meditations to cultivate mindfulness, self-compassion and forgiveness...
September 1, 2017: Journal of Gerontological Social Work
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