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https://www.readbyqxmd.com/read/28338814/korean-pediatric-and-adult-head-computational-phantoms-and-application-to-photon-specific-absorbed-fractions-calculations
#1
Daphnée Villoing, Dayton McMillan, Kwang Pyo Kim, Il Park, Ae-Kyoung Lee, Hyung-do Choi, Choonsik Lee
In recent decades, applications of single photon emission computed tomography and positron emission tomography in clinical neuroimaging have markedly increased. In this study, we developed a series of Korean computational head phantoms with detailed cranial substructures for 6-, 9-, 12- and 15-year-old children and adult by non-uniformly adjusting a template head phantom to match the Korean standard head dimensions. The Korean head phantoms were coupled with a Monte Carlo transport code to calculate age-dependent specific absorbed fraction (SAF) for the combination of 10 source and target regions and mono-energetic photons ranging from 0...
February 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#2
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28329461/cardiac-function-after-tetralogy-of-fallot-complete-atrioventricular-canal-repair
#3
Elizabeth H Stephens, Jennifer Tingo, Marc Najjar, Betul Yilmaz, Stéphanie Levasseur, Jeffrey D Dayton, Ralph S Mosca, Paul Chai, Jan M Quaegebeur, Emile A Bacha
BACKGROUND: Repair of complete atrioventricular canal (CAVC) with tetralogy of Fallot (TOF) is a challenging operation increasingly being performed as a complete, primary repair in infancy. Previous studies have focused on perioperative outcomes; however, midterm valve function, ventricular function, and residual obstruction have received little attention. METHODS: We retrospectively reviewed 20 patients who underwent CAVC/TOF repair (January 2005 to December 2014)...
March 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28325048/photoinduced-single-and-multiple-electron-dynamics-processes-enhanced-by-quantum-confinement-in-lead-halide-perovskite-quantum-dots
#4
Dayton Jon Vogel, Andrei Kryjevski, Talgat M Inerbaev, Dmitri S Kilin
Methyl-ammonium lead iodide perovskite (MAPbI3) is a promising material for photovoltaic devices. A modification of the MAPbI3 into confined nanostructures is expected to further increase efficiency of solar energy conversion. Photo-excited dynamic processes in a MAPbI3 quantum dot (QD) have been modeled by many-body perturbation theory and nonadiabatic dynamics. A photoexcitation is followed by either exciton cooling (EC), its radiative (RR) or non-radiative recombination (NRR), or multi-exciton generation (MEG) processes...
March 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28266925/an-iterative-fullwave-simulation-approach-to-multiple-scattering-in-media-with-randomly-distributed-microbubbles
#5
Aditya Joshi, Brooks Lindsey, Paul Dayton, Gianmarco Pinton, Marie Muller
- Ultrasound contrast agents (UCA), such as microbubbles, enhance the scattering properties of blood, which is otherwise hypoechoic. The multiple scattering interactions of the acoustic field with UCA's are poorly understood due to the complexity of the multiple scattering theories and the nonlinear microbubble response. The majority of bubble models describe the behavior of UCA's as single, isolated microbubbles suspended in infinite medium. Multiple scattering models such as the Independent Scattering Approximation can approximate phase velocity and attenuation for low scatterer volume fraction...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28257681/the-essential-achilles
#6
EDITORIAL
Paul Dayton
No abstract text is available yet for this article.
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28257668/anatomic-vascular-and-mechanical-overview-of-the-achilles-tendon
#7
REVIEW
Paul Dayton
The Achilles tendon is the strongest and thickest tendon in the body and is subjected to unique forces during the activities of living. A variety of pathologic processes have been identified causing clinical symptoms in patients of all ages. A detailed understanding of Achilles anatomy is necessary to understand the pathologic process that are seen in the tendon. As with all medical topics and conditions, our understanding is evolving as new research sheds light on pathologic processes involved with the Achilles tendon...
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28201790/reaching-the-global-target-to-reduce-stunting-an-investment-framework
#8
Meera Shekar, Jakub Kakietek, Mary R D'Alimonte, Hilary E Rogers, Julia Dayton Eberwein, Jon Kweku Akuoku, Audrey Pereira, Shan Soe-Lin, Robert Hecht
No abstract text is available yet for this article.
February 14, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28127427/an-evaluation-of-the-sonoporation-potential-of-low-boiling-point-phase-change-ultrasound-contrast-agents-in-vitro
#9
Samantha M Fix, Anthony Novell, Yeoheung Yun, Paul A Dayton, Christopher B Arena
BACKGROUND: Phase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and their nanometer-scale sizes may allow for passive accumulation in solid tumors. As a first step towards the goal of extravascular cell permeabilization, we aim to characterize the sonoporation potential of a low-boiling point formulation of PCCAs in vitro. METHODS: Parameters to induce acoustic droplet vaporization and subsequent microbubble cavitation were optimized in vitro using high-speed optical microscopy...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28126110/a-comparison-of-network-sampling-designs-for-a-hidden-population-of-drug-users-random-walk-vs-respondent-driven-sampling
#10
David C Bell, Elizabeth B Erbaugh, Tabitha Serrano, Cheryl A Dayton-Shotts, Isaac D Montoya
Both random walk and respondent-driven sampling (RDS) exploit social networks and may reduce biases introduced by earlier methods for sampling from hidden populations. Although RDS has become much more widely used by social researchers than random walk (RW), there has been little discussion of the tradeoffs in choosing RDS over RW. This paper compares experiences of implementing RW and RDS to recruit drug users to a network-based study in Houston, Texas. Both recruitment methods were implemented over comparable periods of time, with the same population, by the same research staff...
February 2017: Social Science Research
https://www.readbyqxmd.com/read/28118939/endonasal-septal-perforation-repair-using-posterior-and-inferiorly-based-mucosal-rotation-flaps
#11
Steven Dayton, Nipun Chhabra, Steven Houser
IMPORTANCE: Repair of nasal septal perforations is challenging regardless of surgical technique due to their location and the health of surrounding tissue. There is currently no surgical procedure which is completely effective in the treatment of anteriorly located perforations. OBJECTIVE: To report a novel method of closing anterior septal perforations using an inferiorly based mucosal rotation flap and an acellular dermal interposition graft, as well as expand upon a previous series...
March 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28113395/optimizing-acoustic-activation-of-phase-change-contrast-agents-with-the-activation-pressure-matching-method-a-review
#12
Juan D Rojas, Paul A Dayton
Sub-micron phase-change contrast agents consist of a liquid perfluorocarbon core that can be vaporized by ultrasound (acoustic droplet vaporization) to generate contrast with excellent spatial and temporal control. When these agents, commonly referred to as nanodroplets, are formulated with cores of low boiling-point perfluorocarbons such as decafluorobutane and octafluoropropane, they can be activated with lowmechanical index imaging pulses for diagnostic applications. Since the utilization of minimum mechanical index is often desirable to avoid unnecessary biological effects, enabling consistent activation of these agents in an acoustic field is a challenge because the energy that must be delivered to achieve the vaporization threshold increases with depth due to attenuation...
October 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28108472/relapsed-acute-promyelocytic-leukemia-lacks-classic-leukemic-promyelocyte-morphology-and-can-create-diagnostic-challenges
#13
Vanessa J Dayton, Robert W McKenna, Sophia L Yohe, Michelle M Dolan, Elizabeth Courville, Harold Alvarez, Michael A Linden
OBJECTIVES: Although current therapies for acute promyelocytic leukemia (APL), such as all-trans retinoic acid and arsenic trioxide, usually result in remission, some patients relapse. Early recognition of relapse is critical for prompt intervention. In this study, we systematically reviewed morphologic, immunophenotypic, and cytogenetic findings in paired diagnostic and relapsed APL cases and describe and quantify the changes in blast morphology at relapse. METHODS: By electronic database search, we identified eight paired diagnostic and relapsed APL cases for which peripheral blood or bone marrow smears were available for review...
January 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28076378/p62-pathology-model-in-the-rat-substantia-nigra-with-filamentous-inclusions-and-progressive-neurodegeneration
#14
Kasey L Jackson, Wen-Lang Lin, Sumitra Miriyala, Robert D Dayton, Manikandan Panchatcharam, Kevin J McCarthy, Monica Castanedes-Casey, Dennis W Dickson, Ronald L Klein
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral sclerosis and inclusion body myositis. Since p62 functions in protein degradation pathways including autophagy, the build-up of p62-positive inclusions suggests defects in protein clearance. p62 was expressed unilaterally in the rat substantia nigra with an adeno-associated virus vector (AAV9) in order to study p62 neuropathology...
2017: PloS One
https://www.readbyqxmd.com/read/28073765/tracing-a-path-to-the-past-exploring-the-use-of-commercial-credit-reporting-data-to-construct-residential-histories-for-epidemiologic-studies-of-environmental-exposures
#15
Susan Hurley, Andrew Hertz, David O Nelson, Michael Layefsky, Julie Von Behren, Leslie Bernstein, Dennis Deapen, Peggy Reynolds
Large-scale environmental epidemiologic studies often rely on exposure estimates based on linkage to residential addresses. This approach, however, is limited by the lack of residential histories typically available for study participants. Our objective was to evaluate the feasibility of using address data from LexisNexis (a division of RELX, Inc., Dayton, Ohio), a commercially available credit reporting company, to construct residential histories for participants in the California Teachers Study (CTS), a prospective cohort study initiated in 1995-1996 to study breast cancer (n = 133,479)...
January 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28060237/a-comparison-of-matched-and-unmatched-orthopaedic-surgery-residency-applicants-from-2006-to-2014-data-from-the-national-resident-matching-program
#16
John B Schrock, Matthew J Kraeutler, Michael R Dayton, Eric C McCarty
BACKGROUND: The Association of American Medical Colleges publishes residency match data and reports through the National Resident Matching Program (NRMP) every year. The purpose of this study was to analyze trends in orthopaedic surgery residency matching data and characteristics of successful applicants to counsel medical students with regard to their chances of matching. METHODS: The annual reports of the NRMP were searched annually from 2006 to 2014 to determine the number of orthopaedic surgery residency positions available, the number of applicants, and the match rate among applicants...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28046261/we-fg-202-02-exploration-of-high-resolution-quantitative-ultrasonic-micro-vascular-imaging-for-early-assessment-of-radiotherapy-tumor-response
#17
S Kasoji, J Rivera, P Dayton, J Buse, S Chang
PURPOSE: Currently, we cannot predict an individual patient's response to a given radiotherapy which normally is not detected for weeks to months post-treatment. As a result, precious time is wasted for patients with unresponsive tumors who could have switched to an alternative treatment much earlier. Presently, no early treatment response detection method exists that is effective, low-cost, non-invasive, and safe. We hypothesize that changes in tumor microvasculature predict tumor response to radiotherapy earlier than tumor volume changes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042332/enhancing-nanoparticle-accumulation-and-retention-in-desmoplastic-tumors-via-vascular-disruption-for-internal-radiation-therapy
#18
Andrew B Satterlee, Juan D Rojas, Paul A Dayton, Leaf Huang
Aggressive, desmoplastic tumors are notoriously difficult to treat because of their extensive stroma, high interstitial pressure, and resistant tumor microenvironment. We have developed a combination therapy that can significantly slow the growth of large, stroma-rich tumors by causing massive apoptosis in the tumor center while simultaneously increasing nanoparticle uptake through a treatment-induced increase in the accumulation and retention of nanoparticles in the tumor. The vascular disrupting agent Combretastatin A-4 Phosphate (CA4P) is able to increase the accumulation of radiation-containing nanoparticles for internal radiation therapy, and the retention of these delivered radioisotopes is maintained over several days...
2017: Theranostics
https://www.readbyqxmd.com/read/28042327/3-d-ultrasound-localization-microscopy-for-identifying-microvascular-morphology-features-of-tumor-angiogenesis-at-a-resolution-beyond-the-diffraction-limit-of-conventional-ultrasound
#19
Fanglue Lin, Sarah E Shelton, David Espíndola, Juan D Rojas, Gianmarco Pinton, Paul A Dayton
Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet ultrasound has been limited in its ability to detect the microvascular changes associated with malignancy. Here, we demonstrate the potential of 'ultrasound localization microscopy' applied volumetrically in combination with quantitative analysis of microvascular morphology, as an approach to overcome this limitation. This pilot study demonstrates our ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe...
2017: Theranostics
https://www.readbyqxmd.com/read/28025076/unusual-extramedullary-hematopoietic-neoplasms-in-lymph-nodes
#20
Vanessa D Dayton, Sarah J Williams, Robert W McKenna, Michael A Linden
Myeloid, plasma cell, and lymphoblastic neoplasms are expected findings in bone marrow but are much less commonly diagnosed as primary processes in lymph nodes. The objective of this review is to aid pathologists in recognizing common hematopoietic neoplasms in the unusual setting of initial presentation in lymph nodes. Review of historical background and evolution of testing strategies is presented in order to improve understanding of the need for accurate diagnosis and classification using current nomenclature...
December 23, 2016: Human Pathology
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