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https://www.readbyqxmd.com/read/29399650/lc-ms-ms-based-method-for-the-multiplex-detection-of-24-fentanyl-analogues-and-metabolites-in-whole-blood-at-sub-ng-ml-1-concentrations
#1
Kraig E Strayer, Heather M Antonides, Matthew P Juhascik, Raminta Daniulaityte, Ioana E Sizemore
The United States and numerous other countries worldwide are currently experiencing a public health crisis due to the abuse of illicitly manufactured fentanyl (IMF) and its analogues. This manuscript describes the development of a liquid chromatography-tandem mass spectrometry-based method for the multiplex detection of N = 24 IMF analogues and metabolites in whole blood at concentrations as low as 0.1-0.5 ng mL-1. These available IMFs were fentanyl, norfentanyl, furanyl norfentanyl, remifentanil acid, butyryl norfentanyl, remifentanil, acetyl fentanyl, alfentanil, AH-7921, U-47700, acetyl fentanyl 4-methylphenethyl, acrylfentanyl, para-methoxyfentanyl, despropionyl fentanyl (4-ANPP), furanyl fentanyl, despropionyl para-fluorofentanyl, carfentanil, (±)-cis-3-methyl fentanyl, butyryl fentanyl, isobutyryl fentanyl, sufentanil, valeryl fentanyl, para-fluorobutyryl fentanyl, and para-fluoroisobutyryl fentanyl...
January 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/29373606/modulation-of-hiv-replication-in-monocyte-derived-macrophages-mdm-by-steroid-hormones
#2
Krishnakumar Devadas, Santanu Biswas, Viswanath Ragupathy, Sherwin Lee, Andrew Dayton, Indira Hewlett
Significant sex specific differences in the progression of HIV/AIDS have been reported. Several studies have implicated steroid hormones in regulating host factor expression and modulating HIV transmission and replication. However, the exact mechanism exerted by steroid hormones estrogen and progesterone in the regulation of HIV-1 replication is still unclear. Results from the current study indicated a dose dependent down regulation of HIV-1 replication in monocyte derived macrophages pre-treated with high concentrations of estrogen or progesterone...
2018: PloS One
https://www.readbyqxmd.com/read/29322935/classifying-cancer-genome-aberrations-by-their-mutually-exclusive-effects-on-transcription
#3
Jonathan B Dayton, Stephen R Piccolo
BACKGROUND: Malignant tumors are typically caused by a conglomeration of genomic aberrations-including point mutations, small insertions, small deletions, and large copy-number variations. In some cases, specific chemotherapies and targeted drug treatments are effective against tumors that harbor certain genomic aberrations. However, predictive aberrations (biomarkers) have not been identified for many tumor types and treatments. One way to address this problem is to examine the downstream, transcriptional effects of genomic aberrations and to identify characteristic patterns...
December 21, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29306336/effectiveness-of-echocardiography-simulation-training-for-paediatric-cardiology-fellows-in-chd
#4
Jeffrey D Dayton, Alan M Groves, Julie S Glickstein, Patrick A Flynn
Simulation is used in many aspects of medical training but less so for echocardiography instruction in paediatric cardiology. We report our experience with the introduction of simulator-based echocardiography training at Weill Cornell Medicine for paediatric cardiology fellows of the New York-Presbyterian Hospital of Columbia University and Weill Cornell Medicine. Knowledge of CHD and echocardiographic performance improved following simulation-based training. Simulator training in echocardiography can be an effective addition to standard training for paediatric cardiology trainees...
January 8, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29291243/resilience-and-efficiency-in-transportation-networks
#5
Alexander A Ganin, Maksim Kitsak, Dayton Marchese, Jeffrey M Keisler, Thomas Seager, Igor Linkov
Urban transportation systems are vulnerable to congestion, accidents, weather, special events, and other costly delays. Whereas typical policy responses prioritize reduction of delays under normal conditions to improve the efficiency of urban road systems, analytic support for investments that improve resilience (defined as system recovery from additional disruptions) is still scarce. In this effort, we represent paved roads as a transportation network by mapping intersections to nodes and road segments between the intersections to links...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29290799/early-assessment-of-tumor-response-to-radiation-therapy-using-high-resolution-quantitative-microvascular-ultrasound-imaging
#6
Sandeep K Kasoji, Judith N Rivera, Ryan C Gessner, Sha X Chang, Paul A Dayton
Measuring changes in tumor volume using anatomical imaging weeks to months post radiation therapy (RT) is currently the clinical standard for indicating treatment response to RT. For patients whose tumors do not respond successfully to treatment, this approach is suboptimal as timely modification of the treatment approach may lead to better clinical outcomes. We propose to use tumor microvasculature as a biomarker for early assessment of tumor response to RT. Acoustic angiography is a novel contrast ultrasound imaging technique that enables high-resolution microvascular imaging and has been shown to detect changes in microvascular structure due to cancer growth...
2018: Theranostics
https://www.readbyqxmd.com/read/29290798/ultrasound-molecular-imaging-of-vegfr-2-in-clear-cell-renal-cell-carcinoma-tracks-disease-response-to-antiangiogenic-and-notch-inhibition-therapy
#7
Juan D Rojas, Fanglue Lin, Yun-Chen Chiang, Anna Chytil, Diana C Chong, Victoria L Bautch, W Kimryn Rathmell, Paul A Dayton
Metastatic clear-cell renal cell carcinoma (ccRCC) affects thousands of patients worldwide each year. Antiangiogenic therapy has been shown to have beneficial effects initially, but resistance is eventually developed. Therefore, it is important to accurately track the response of cancer to different therapeutics in order to appropriately adjust the therapy to maximize efficacy. Change in tumor volume is the current gold standard for determining efficacy of treatment. However, functional variations can occur much earlier than measurable volume changes...
2018: Theranostics
https://www.readbyqxmd.com/read/29286658/predicting-displaceable-water-sites-using-mixed-solvent-molecular-dynamics
#8
Sarah Graham, Richard Dayton Smith, Heather Ann Carlson
Water molecules are an important factor in protein-ligand binding. Upon binding of a ligand with a protein's surface, waters can either be displaced by the ligand or may be conserved and possibly bridge interactions between the protein and ligand. Depending on the specific interactions made by the ligand, displacing waters can yield a gain in binding affinity. The extent to which binding affinity may increase is difficult to predict, as the favorable displacement of a water molecule is dependent on the site-specific interactions made by the water and the potential ligand...
December 29, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29284574/american-college-of-foot-and-ankle-surgeons-clinical-consensus-statement-diagnosis-and-treatment-of-adult-acquired-infracalcaneal-heel-pain
#9
REVIEW
Harry P Schneider, John Baca, Brian Carpenter, Paul Dayton, Adam E Fleischer, Brett D Sachs
Adult acquired inferior calcaneal heel pain is a common pathology seen in a foot and ankle practice. A literature review and expert panel discussion of the most common findings and treatment options are presented. Various diagnostic and treatment modalities are available to the practitioner. It is prudent to combine appropriate history and physical examination findings with patient-specific treatment modalities for optimum success. We present the most common diagnostic tools and treatment options, followed by a discussion of the appropriateness of each based on the published data and experience of the expert panel...
December 25, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29260735/focused-ultrasound-facilitated-brain-drug-delivery-using-optimized-nanodroplets-vaporization-efficiency-dictates-large-molecular-delivery
#10
Shih-Ying Wu, Samantha M Fix, Christopher B Arena, Cherry C Chen, Wenlan Zheng, Oluyemi O Olumolade, Virginie Papadopoulou, Anthony Novell, Paul A Dayton, Elisa E Konofagou
Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization with potentially improved in vivo stability, drug payload, and minimal interference outside of the focal zone compared with microbubbles. While the feasibility of blood-brain barrier (BBB) opening using nanodroplets has been previously reported, characterization of the associated delivery has not been achieved. It was hypothesized that the outcome of drug delivery was associated with the droplet's sensitivity to acoustic energy, and can be modulated with the boiling point of the liquid core...
December 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29214019/pkm2-is-not-required-for-colon-cancer-initiated-by-apc-loss
#11
Allison N Lau, William J Israelsen, Jatin Roper, Mark J Sinnamon, Larissa Georgeon, Talya L Dayton, Alissandra L Hillis, Omer H Yilmaz, Dolores Di Vizio, Kenneth E Hung, Matthew G Vander Heiden
Background: Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic role in β-catenin nuclear translocation. PKM2 is expressed in colon cancers where loss of the Apc tumor suppressor results in β-catenin nuclear translocation and aberrant activation of the canonical Wnt signaling pathway...
2017: Cancer & Metabolism
https://www.readbyqxmd.com/read/29196604/camkii-regulates-the-de-palmitoylation-and-synaptic-removal-of-akap79-150-to-mediate-structural-ltd
#12
Kevin M Woolfrey, Heather O'Leary, Dayton J Goodell, Holly R Robertson, Eric A Horne, Steven J Coultrap, Mark L Dell'Acqua, K Ulrich Bayer
Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by T286 autophosphorylation. Additionally, LTP and LTD are correlated with dendritic spine enlargement and shrinkage that are accompanied by the synaptic accumulation or removal, respectively, of the AMPA-receptor regulatory scaffold protein A-kinase anchoring protein (AKAP) 79/150. We show here that the spine shrinkage associated with LTD indeed requires synaptic AKAP79/150 removal, which in turn requires CaMKII activity...
December 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29156165/understanding-frontal-plane-correction-in-hallux-valgus-repair
#13
REVIEW
W Bret Smith, Paul Dayton, Robert D Santrock, Daniel J Hatch
Hallux-abducto-valgus or "bunion" surgery is one of the most common surgical procedures for the foot and ankle specialist. As our understanding of the hallux-abducto-valgus deformity has grown, it is becoming clear that the anatomic CORA of the deformity may lie at the tarsometatarsal joint. There is also the component of the 3-dimensional nature of the deformity that may be best addressed at this CORA. With these issues in mind, it was necessary to address the shortcomings of the traditional Lapidus procedure and progress toward more consistent, instrumented steps that could address the 3-dimensional nature of the deformity...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29153853/community-pharmacist-collaboration-with-a-patient-centered-medical-home-establishment-of-a-patient-centered-medical-neighborhood-and-payment-model
#14
Heidi R Luder, Pam Shannon, James Kirby, Stacey M Frede
OBJECTIVES: To determine the feasibility of a partnership between a community pharmacy and a patient-centered medical home (PCMH) by measuring the impact on office- and patient-level clinical outcomes. SETTING: Kroger Pharmacy and a PCMH practice in Cincinnati, OH. PRACTICE DESCRIPTION: The Kroger Co. is a large grocery store chain that operates 102 pharmacies in the Cincinnati-Dayton marketing area. The PCMH practice is an accredited PCMH office serving more than 9000 patients in the Cincinnati area...
November 15, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29140404/evaluation-of-opportunities-to-improve-hematopathology-diagnosis-for-vietnam-pathologists
#15
Vanessa Dayton, Chi Kim Nguyen, Trinh Thu Van, Nguyen Van Thanh, Ta Van To, Nguyen Phi Hung, Nguyen Ngoc Dung, Danny A Milner
Objectives: We evaluate the need for, feasibility of, and impediments to improving hematopathology diagnoses for cancer hospitals in Vietnam. Methods: Two hematopathologists from the United States visited three major cancer treatment hospitals in Vietnam to workshop a sampling of difficult hematopathology cases. With Vietnamese pathologists, they toured histopathology, immunohistochemistry, and ancillary laboratory facilities. Results: Automated tissue processors and slide staining equipment were documented for each of the three hospitals...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29133343/clinical-and-histologic-characterization-of-nonalcoholic-steatohepatitis-in-african-american-patients
#16
Fernando Bril, Paola Portillo-Sanchez, I-Chia Liu, Srilaxmi Kalavalapalli, Kristin Dayton, Kenneth Cusi
OBJECTIVE: There has been a widespread misconception among physicians that African Americans are protected from developing nonalcoholic steatohepatitis (NASH). However, a formal histologic and metabolic comparison against well-matched Caucasians has never been performed. RESEARCH DESIGN AND METHODS: Sixty-seven African American patients were matched 2:1 to Caucasians (n = 134) for age, sex, BMI, hemoglobin A1c, and prevalence of type 2 diabetes mellitus (T2DM). Screening for NASH included measurement of intrahepatic triglyceride content by proton MRS ((1)H-MRS), followed by a liver biopsy if patients had hepatic steatosis...
November 13, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29096546/memory-keeper-a-prototype-digital-application-to-improve-engagement-with-people-with-dementia-in-long-term-care-innovative-practice
#17
Margaret McAllister, Jeanne Dayton, Florin Oprescu, Mary Katsikitis, Christian M Jones
People with dementia living in long-term care commonly experience loneliness and lack of meaningful activity. Memory Keeper is a prototype digital application that presents personalised prompts to stimulate reminiscences and meaningful engagement with formal and informal carers. A trial involving three persons with dementia in long-term care and seven family and staff members revealed no negative responses to the device or application. Family members said it was valuable in improving the quality of engagement and made visits more enjoyable...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29076807/photon-management-in-supramolecular-peptide-nanomaterials
#18
John Dayton Tovar
Self-assembling peptides with covalent pi-electron functionality offer new ways to create delocalized conduits within protein-based nanomaterials. Our recent research is summarized in this regard, detailing foundational self-assembly and photophysical characterizations that validate the electronic couplings existing within the resulting peptidic nanomaterials. Using these initial studies as a benchmark, ongoing studies to create even more complex photonic energy delocalization schemes are presented, spanning excitonic and Förster energy transfer to low-bandgap dopant sites (whereby 46% of the observed photoluminescence could be quenched by the addition of 1 mol% of an energy acceptor), the creation of charge separated states following photoinduced electron transfer that persisted for over a nanosecond, and use of kinetic control to dictate self-sorting (at long time scales, ca...
October 27, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#19
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28990871/cultural-adaptation-of-a-dyadic-intervention-for-korean-couples-coping-with-alzheimer-s-disease
#20
Minyoung Kwak, Jung-Hwa Ha, So-Yeon Hwang, Berit Ingersoll-Dayton, Beth Spencer
OBJECTIVES: The Couples Life Story Approach (CLSA) was recently reveloped in the U.S. for older couples dealing with dementia to improve their quality of life. The purpose of this article is to describe how the CLSA was adapted to be culturally appropriate for older Korean couples and to discuss cultural htemes that emerged during the implementation process. METHODS: The intervention was adapted using the Cultural Adaptation Process Model. The revised materials were implemented on 56 Korean couples...
August 16, 2017: Clinical Gerontologist
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