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https://www.readbyqxmd.com/read/28201790/reaching-the-global-target-to-reduce-stunting-an-investment-framework
#1
Meera Shekar, Jakub Kakietek, Mary R D'Alimonte, Hilary E Rogers, Julia Dayton Eberwein, Jon Kweku Akuoku, Audrey Pereira, Shan Soe-Lin, Robert Hecht
No abstract text is available yet for this article.
February 14, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28127427/an-evaluation-of-the-sonoporation-potential-of-low-boiling-point-phase-change-ultrasound-contrast-agents-in-vitro
#2
Samantha M Fix, Anthony Novell, Yeoheung Yun, Paul A Dayton, Christopher B Arena
BACKGROUND: Phase-change ultrasound contrast agents (PCCAs) offer a solution to the inherent limitations associated with using microbubbles for sonoporation; they are characterized by prolonged circulation lifetimes, and their nanometer-scale sizes may allow for passive accumulation in solid tumors. As a first step towards the goal of extravascular cell permeabilization, we aim to characterize the sonoporation potential of a low-boiling point formulation of PCCAs in vitro. METHODS: Parameters to induce acoustic droplet vaporization and subsequent microbubble cavitation were optimized in vitro using high-speed optical microscopy...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28126110/a-comparison-of-network-sampling-designs-for-a-hidden-population-of-drug-users-random-walk-vs-respondent-driven-sampling
#3
David C Bell, Elizabeth B Erbaugh, Tabitha Serrano, Cheryl A Dayton-Shotts, Isaac D Montoya
Both random walk and respondent-driven sampling (RDS) exploit social networks and may reduce biases introduced by earlier methods for sampling from hidden populations. Although RDS has become much more widely used by social researchers than random walk (RW), there has been little discussion of the tradeoffs in choosing RDS over RW. This paper compares experiences of implementing RW and RDS to recruit drug users to a network-based study in Houston, Texas. Both recruitment methods were implemented over comparable periods of time, with the same population, by the same research staff...
February 2017: Social Science Research
https://www.readbyqxmd.com/read/28118939/endonasal-septal-perforation-repair-using-posterior-and-inferiorly-based-mucosal-rotation-flaps
#4
Steven Dayton, Nipun Chhabra, Steven Houser
IMPORTANCE: Repair of nasal septal perforations is challenging regardless of surgical technique due to their location and the health of surrounding tissue. There is currently no surgical procedure which is completely effective in the treatment of anteriorly located perforations. OBJECTIVE: To report a novel method of closing anterior septal perforations using an inferiorly based mucosal rotation flap and an acellular dermal interposition graft, as well as expand upon a previous series...
January 16, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28113395/optimizing-acoustic-activation-of-phase-change-contrast-agents-with-the-activation-pressure-matching-method-a-review
#5
Juan D Rojas, Paul A Dayton
Sub-micron phase-change contrast agents consist of a liquid perfluorocarbon core that can be vaporized by ultrasound (acoustic droplet vaporization) to generate contrast with excellent spatial and temporal control. When these agents, commonly referred to as nanodroplets, are formulated with cores of low boiling-point perfluorocarbons such as decafluorobutane and octafluoropropane, they can be activated with lowmechanical index imaging pulses for diagnostic applications. Since the utilization of minimum mechanical index is often desirable to avoid unnecessary biological effects, enabling consistent activation of these agents in an acoustic field is a challenge because the energy that must be delivered to achieve the vaporization threshold increases with depth due to attenuation...
October 12, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28108472/relapsed-acute-promyelocytic-leukemia-lacks-classic-leukemic-promyelocyte-morphology-and-can-create-diagnostic-challenges
#6
Vanessa J Dayton, Robert W McKenna, Sophia L Yohe, Michelle M Dolan, Elizabeth Courville, Harold Alvarez, Michael A Linden
OBJECTIVES: Although current therapies for acute promyelocytic leukemia (APL), such as all-trans retinoic acid and arsenic trioxide, usually result in remission, some patients relapse. Early recognition of relapse is critical for prompt intervention. In this study, we systematically reviewed morphologic, immunophenotypic, and cytogenetic findings in paired diagnostic and relapsed APL cases and describe and quantify the changes in blast morphology at relapse. METHODS: By electronic database search, we identified eight paired diagnostic and relapsed APL cases for which peripheral blood or bone marrow smears were available for review...
January 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28076378/p62-pathology-model-in-the-rat-substantia-nigra-with-filamentous-inclusions-and-progressive-neurodegeneration
#7
Kasey L Jackson, Wen-Lang Lin, Sumitra Miriyala, Robert D Dayton, Manikandan Panchatcharam, Kevin J McCarthy, Monica Castanedes-Casey, Dennis W Dickson, Ronald L Klein
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic lateral sclerosis and inclusion body myositis. Since p62 functions in protein degradation pathways including autophagy, the build-up of p62-positive inclusions suggests defects in protein clearance. p62 was expressed unilaterally in the rat substantia nigra with an adeno-associated virus vector (AAV9) in order to study p62 neuropathology...
2017: PloS One
https://www.readbyqxmd.com/read/28073765/tracing-a-path-to-the-past-exploring-the-use-of-commercial-credit-reporting-data-to-construct-residential-histories-for-epidemiologic-studies-of-environmental-exposures
#8
Susan Hurley, Andrew Hertz, David O Nelson, Michael Layefsky, Julie Von Behren, Leslie Bernstein, Dennis Deapen, Peggy Reynolds
Large-scale environmental epidemiologic studies often rely on exposure estimates based on linkage to residential addresses. This approach, however, is limited by the lack of residential histories typically available for study participants. Our objective was to evaluate the feasibility of using address data from LexisNexis (a division of RELX, Inc., Dayton, Ohio), a commercially available credit reporting company, to construct residential histories for participants in the California Teachers Study (CTS), a prospective cohort study initiated in 1995-1996 to study breast cancer (n = 133,479)...
January 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28060237/a-comparison-of-matched-and-unmatched-orthopaedic-surgery-residency-applicants-from-2006-to-2014-data-from-the-national-resident-matching-program
#9
John B Schrock, Matthew J Kraeutler, Michael R Dayton, Eric C McCarty
BACKGROUND: The Association of American Medical Colleges publishes residency match data and reports through the National Resident Matching Program (NRMP) every year. The purpose of this study was to analyze trends in orthopaedic surgery residency matching data and characteristics of successful applicants to counsel medical students with regard to their chances of matching. METHODS: The annual reports of the NRMP were searched annually from 2006 to 2014 to determine the number of orthopaedic surgery residency positions available, the number of applicants, and the match rate among applicants...
January 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28046261/we-fg-202-02-exploration-of-high-resolution-quantitative-ultrasonic-micro-vascular-imaging-for-early-assessment-of-radiotherapy-tumor-response
#10
S Kasoji, J Rivera, P Dayton, J Buse, S Chang
PURPOSE: Currently, we cannot predict an individual patient's response to a given radiotherapy which normally is not detected for weeks to months post-treatment. As a result, precious time is wasted for patients with unresponsive tumors who could have switched to an alternative treatment much earlier. Presently, no early treatment response detection method exists that is effective, low-cost, non-invasive, and safe. We hypothesize that changes in tumor microvasculature predict tumor response to radiotherapy earlier than tumor volume changes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042332/enhancing-nanoparticle-accumulation-and-retention-in-desmoplastic-tumors-via-vascular-disruption-for-internal-radiation-therapy
#11
Andrew B Satterlee, Juan D Rojas, Paul A Dayton, Leaf Huang
Aggressive, desmoplastic tumors are notoriously difficult to treat because of their extensive stroma, high interstitial pressure, and resistant tumor microenvironment. We have developed a combination therapy that can significantly slow the growth of large, stroma-rich tumors by causing massive apoptosis in the tumor center while simultaneously increasing nanoparticle uptake through a treatment-induced increase in the accumulation and retention of nanoparticles in the tumor. The vascular disrupting agent Combretastatin A-4 Phosphate (CA4P) is able to increase the accumulation of radiation-containing nanoparticles for internal radiation therapy, and the retention of these delivered radioisotopes is maintained over several days...
2017: Theranostics
https://www.readbyqxmd.com/read/28042327/3-d-ultrasound-localization-microscopy-for-identifying-microvascular-morphology-features-of-tumor-angiogenesis-at-a-resolution-beyond-the-diffraction-limit-of-conventional-ultrasound
#12
Fanglue Lin, Sarah E Shelton, David Espíndola, Juan D Rojas, Gianmarco Pinton, Paul A Dayton
Angiogenesis has been known as a hallmark of solid tumor cancers for decades, yet ultrasound has been limited in its ability to detect the microvascular changes associated with malignancy. Here, we demonstrate the potential of 'ultrasound localization microscopy' applied volumetrically in combination with quantitative analysis of microvascular morphology, as an approach to overcome this limitation. This pilot study demonstrates our ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe...
2017: Theranostics
https://www.readbyqxmd.com/read/28025076/unusual-extramedullary-hematopoietic-neoplasms-in-lymph-nodes
#13
Vanessa D Dayton, Sarah J Williams, Robert W McKenna, Michael A Linden
Myeloid, plasma cell, and lymphoblastic neoplasms are expected findings in bone marrow but are much less commonly diagnosed as primary processes in lymph nodes. The objective of this review is to aid pathologists in recognizing common hematopoietic neoplasms in the unusual setting of initial presentation in lymph nodes. Review of historical background and evolution of testing strategies is presented in order to improve understanding of the need for accurate diagnosis and classification using current nomenclature...
December 23, 2016: Human Pathology
https://www.readbyqxmd.com/read/28008310/corrigendum-better-targeting-better-efficiency-for-wide-scale-neuronal-transduction-with-the-synapsin-promoter-and-aav-php-b
#14
Kasey L Jackson, Robert D Dayton, Benjamin E Deverman, Ronald L Klein
[This corrects the article on p. 116 in vol. 9, PMID: 27867348.].
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28004406/development-and-socialization-of-physical-aggression-in-very-young-boys
#15
Carolyn Joy Dayton, Johanna C Malone
The expression of physical aggression is normative in early child development; it peaks in the second year of life, with steep declines for most children by the third and fourth years as children learn alternatives to aggression. Some children, however, fail to demonstrate declines in aggressive acts, and many of these are boys. The current review uses a dynamic systems (DS) approach to identify early individual and contextual factors that may dynamically influence trajectories of aggression as a characteristic way of engaging within communities and relationships...
January 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/27990585/vengeance-condomless-sex-and-hiv-disclosure-among-men-who-have-sex-with-men-living-with-hiv
#16
Monique J Brown, Julianne M Serovich, Judy A Kimberly, Jinxiang Hu
Vengeance has been shown to be a risk factor for HIV nondisclosure. Research examining the associations between vengeance, condomless sex, and HIV nondisclosure is lacking. The aim of the current study was to explore the association between vengeance, condomless sex and disclosure (behavior, attitude and intention) among men who have sex with men (MSM) living with HIV. Participants included 266 MSM who were a part of a disclosure intervention study. Men were recruited from local and state AIDS service organizations (ASOs), HIV-related venues and forums, and at local eating and drinking establishments in Tampa, Florida, and Columbus and Dayton, Ohio metropolitan statistical areas (MSAs)...
December 19, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27956109/practical-steps-to-integrate-family-voice-in-organization-policy-planning-and-decision-making-for-socio-emotional-trauma-informed-integrated-pediatric-care
#17
Lauren Dayton, Amelia Buttress, Jen Agosti, Javier Aceves, Meredith Kieschnick, Agatha Popejoy, Robyn Robbins, Kate Farinholt
This article explores barriers and strategies to achieving family-driven integrated child health care. Family involvement in health system design and reform has become a guiding principle in national and local efforts to improve children's mental health services. In practice, primary care clinicians, staff, and families continue to describe common barriers to integrating family voice. Drawing from the collective knowledge of the Pediatric Integrated Care Collaborative (PICC) and the National Alliance on Mental Illness (NAMI), we present strategies to overcome these barriers to successfully recruit, sustain, and expand family influence on health systems...
December 2016: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27940120/integrating-mental-and-physical-health-services-using-a-socio-emotional-trauma-lens
#18
Lauren Dayton, Jen Agosti, Deirdre Bernard-Pearl, Marian Earls, Kate Farinholt, Betsy McAlister Groves, Mark Rains, Barry Sarvet, Holly C Wilcox, Lawrence S Wissow
This article provides a synthesis of the lessons learned from the Pediatric Integrated Care Collaborative (PICC), a SAMHSA-funded project that is part of the National Child Traumatic Stress Network. The high prevalence of trauma exposure in childhood and shortage of mental health services has informed efforts to integrate mental and behavioral health services in pediatric primary care. This article outlines strategies to integrate care following the six goals of the PICC change framework: create a trauma/mental health informed office; involve families in program development; collaborate and coordinate with mental health services; promote resilience and prevent mental health problems through a particular focus on trauma-related risks; assess trauma-related somatic and mental health issues; and address trauma-related somatic and mental heath issues...
December 2016: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27939052/acoustic-behavior-of-a-reactivated-commercially-available-ultrasound-contrast-agent
#19
Songita A Choudhury, Feng Xie, Paul A Dayton, Thomas R Porter
BACKGROUND: Commercially available microbubbles such as Definity contain octafluoropropane encapsulated in a lipid shell. This perfluorocarbon can be compressed into liquid nanodroplets at room temperatures and activated with transthoracic diagnostic ultrasound. The aim of this study was to determine the size range and acoustic characteristics of Definity nanodroplets (DNDs) compared with Definity microbubbles (DMBs). METHODS: An in vitro flow system was used with a diagnostic ultrasound transducer (S5-1, iE33)...
December 6, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27910306/a-high-speed-two-frame-1-2-ns-gated-x-ray-cmos-imager-used-as-a-hohlraum-diagnostic-on-the-national-ignition-facility-invited
#20
Hui Chen, N Palmer, M Dayton, A Carpenter, M B Schneider, P M Bell, D K Bradley, L D Claus, L Fang, T Hilsabeck, M Hohenberger, O S Jones, J D Kilkenny, M W Kimmel, G Robertson, G Rochau, M O Sanchez, J W Stahoviak, D C Trotter, J L Porter
A novel x-ray imager, which takes time-resolved gated images along a single line-of-sight, has been successfully implemented at the National Ignition Facility (NIF). This Gated Laser Entrance Hole diagnostic, G-LEH, incorporates a high-speed multi-frame CMOS x-ray imager developed by Sandia National Laboratories to upgrade the existing Static X-ray Imager diagnostic at NIF. The new diagnostic is capable of capturing two laser-entrance-hole images per shot on its 1024 × 448 pixels photo-detector array, with integration times as short as 1...
November 2016: Review of Scientific Instruments
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