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https://www.readbyqxmd.com/read/28705744/the-relationship-between-ocular-trauma-and-substance-abuse-in-emergency-department-patients
#1
Sylvia L Chang, Vaama Patel, John Giltner, Richard Lee, Catherine A Marco
INTRODUCTION: Eye injury is the second most common cause of visual impairment and a leading cause of monocular blindness in the United States. There are approximately 6 million ED visits related to drug use annually, including misuse or abuse of pharmaceuticals and illicit drug use. The purpose of this study was to assess the relationship between ocular trauma and substance abuse among emergency department patients and to assess that relationship with demographic factors, including age and gender...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28668636/optimizing-sensitivity-of-ultrasound-contrast-enhanced-super-resolution-imaging-by-tailoring-size-distribution-of-microbubble-contrast-agent
#2
Fanglue Lin, James K Tsuruta, Juan D Rojas, Paul A Dayton
Ultrasound contrast-enhanced super-resolution imaging has recently attracted attention because of its extraordinary ability to image vascular features much smaller than the ultrasound diffraction limit. This method requires sensitive detection of separable microbubble events despite a noisy tissue background to indicate the microvasculature, and any approach that could improve the sensitivity of the ultrasound system to individual microbubbles would be highly beneficial. In this study, we evaluated the effect of varying microbubble size on super-resolution imaging sensitivity...
June 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28665536/mixed-methods-evaluation-of-participant-recruitment-and-retention-in-the-mom-power-parenting-intervention-program
#3
Lilia E Mucka, Carolyn J Dayton, Jamie Lawler, Rosalind Kirk, Emily Alfafara, Melisa M Schuster, Nicole Miller, Julie Ribaudo, Katherine Lisa Rosenblum, Maria Muzik
Parenting group success begins with attendance. Using archival pilot data from 99 mothers who enrolled in the Mom Power (MP) parenting intervention, this study sought to understand the factors that influenced participant engagement and retention. MP is a group-based, early intervention program grounded in attachment theory that utilizes motivational interviewing as a core component to enhance program engagement. Study aims were to qualitatively describe the reasons why mothers were interested in participating in the program, including what they hoped to gain from the experience, and to quantitatively examine the extent to which attendance was associated with demographic, experiential, and psychosocial factors...
July 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28652369/quantitative-proteomics-identify-tenascin-c-as-a-promoter-of-lung-cancer-progression-and-contributor-to-a-signature-prognostic-of-patient-survival
#4
Vasilena Gocheva, Alexandra Naba, Arjun Bhutkar, Talia Guardia, Kathryn M Miller, Carman Man-Chung Li, Talya L Dayton, Francisco J Sanchez-Rivera, Caroline Kim-Kiselak, Noor Jailkhani, Monte M Winslow, Amanda Del Rosario, Richard O Hynes, Tyler Jacks
The extracellular microenvironment is an integral component of normal and diseased tissues that is poorly understood owing to its complexity. To investigate the contribution of the microenvironment to lung fibrosis and adenocarcinoma progression, two pathologies characterized by excessive stromal expansion, we used mouse models to characterize the extracellular matrix (ECM) composition of normal lung, fibrotic lung, lung tumors, and metastases. Using quantitative proteomics, we identified and assayed the abundance of 113 ECM proteins, which revealed robust ECM protein signatures unique to fibrosis, primary tumors, or metastases...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28648493/the-use-of-fructosamine-in-cystic-fibrosis-related-diabetes-cfrd-screening
#5
Grace Y Lam, Michelle Doll-Shankaruk, Jan Dayton, Karina Rodriguez-Capote, Trefor N Higgins, Dylan Thomas, Kimberley Mulchey, Maeve P Smith, Neil E Brown, Winnie M Leung, Mathew P Estey
OBJECTIVE: To determine whether serum fructosamine correlates with glycemic control and clinical outcomes in patients being screened for cystic fibrosis-related diabetes (CFRD). METHODS: Fructosamine and percent predicted forced expiratory volume in 1s (FEV1) were measured in patients undergoing a 2h oral glucose tolerance test (OGTT) for CFRD screening. Fractional serum fructosamine (FSF) was calculated as fructosamine/total protein. RESULTS: FSF exhibited a positive correlation with 2h OGTT results (r(2)=0...
June 22, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28637214/health-and-social-physical-environment-profiles-among-older-adults-living-alone-associations-with-depressive-symptoms
#6
Sojung Park, Jacqui Smith, Ruth E Dunkle, Berit Ingersoll-Dayton, Toni C Antonucci
Objectives: We examined differences in depressive symptoms among people 65 and older who live alone, exploring whether these differences are associated with both health and environmental contexts. Method: Data are from the 2006 wave of Health Retirement Study (N = 2,956, age range: 65-104). We used a two-step cluster analytical approach to identify subgroups of health-limitation profiles and environmental profiles. Logistic regression models determined associations between subgroups and depressive symptoms...
June 20, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28615645/intravascular-forward-looking-ultrasound-transducers-for-microbubble-mediated-sonothrombolysis
#7
Jinwook Kim, Brooks D Lindsey, Wei-Yi Chang, Xuming Dai, Joseph M Stavas, Paul A Dayton, Xiaoning Jiang
Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614711/dapk1-mediates-ltd-by-making-camkii-glun2b-binding-ltp-specific
#8
Dayton J Goodell, Vincent Zaegel, Steven J Coultrap, Johannes W Hell, K Ulrich Bayer
The death-associated protein kinase 1 (DAPK1) is a potent mediator of neuronal cell death. Here, we find that DAPK1 also functions in synaptic plasticity by regulating the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII). CaMKII and T286 autophosphorylation are required for both long-term potentiation (LTP) and depression (LTD), two opposing forms of synaptic plasticity underlying learning, memory, and cognition. T286-autophosphorylation induces CaMKII binding to the NMDA receptor (NMDAR) subunit GluN2B, which mediates CaMKII synaptic accumulation during LTP...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28530123/-we-are-a-team-couple-identity-and-memory-loss
#9
Elise Hernandez, Beth Spencer, Berit Ingersoll-Dayton, Alexandra Faber, Allison Ewert
Couplehood can be an important source of resilience in the face of memory loss, but couple identity has only recently been explored and has rarely been measured. This paper examines older spouses' descriptions of their couple identity and discusses salient themes. Data come from 19 couples from the Couples Life Story Project, a life review intervention where one partner has memory loss. Using baseline data, we analyzed how partners depicted their couple identity using a series of separate and overlapping circles...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28513530/an-analysis-of-child-deaths-by-suicide-in-queensland-australia-2004-2012-what-are-we-missing-from-a-preventative-health-services-perspective
#10
Florin Oprescu, Bridie Scott-Parker, Jeanne Dayton
BACKGROUND: This article analyses case descriptions of child suicides from 2004 to 2012 toinform future policy and practice. METHODS: Quantitative data and case descriptions for 159 child suicides (under 18 years) in Queensland, Australia, were analysed quantitatively using SPSS and qualitatively using automated content analyzis (Leximancer). RESULTS: More than three quarters of child suicides involved hanging and 81% of suicides occurred in the family home...
June 1, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/28489536/dual-frequency-piezoelectric-endoscopic-transducer-for-imaging-vascular-invasion-in-pancreatic-cancer
#11
Brooks D Lindsey, Jinwook Kim, Paul A Dayton, Xiaoning Jiang
Cancers of the pancreas have the poorest prognosis among all cancers, as many tumors are not detected until surgery is no longer a viable option. Surgical viability is typically determined via endoscopic ultrasound imaging. However, many patients who may be eligible for resection are not offered surgery due to diagnostic challenges in determining vascular or lymphatic invasion. In this paper, we describe the development of a dual-frequency piezoelectric transducer for rotational endoscopic imaging designed to transmit at 4 MHz and receive at 20 MHz in order to image microbubble-specific superharmonic signals...
July 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28488434/can-you-be-smart-and-resilient-at-the-same-time
#12
Dayton Marchese, Igor Linkov
No abstract text is available yet for this article.
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28473300/allelic-frequencies-of-the-hs1-2-enhancer-within-the-immunoglobulin-heavy-chain-region-in-dayton-ohio-patients-screened-for-celiac-disease-with-duodenal-biopsy
#13
Jing Liu, Rebecca A Law, Paul G Koles, Jonathan C Saxe, Michael Bottomley, Courtney E W Sulentic
BACKGROUND: Genetic and environmental factors contribute to the development of celiac disease (CD), but specific genetic predisposing factors remain poorly understood. One candidate is allele 2 of the hs1.2 enhancer within the immunoglobulin heavy chain region. In humans, there are four possible alleles and a previous study of an Italian cohort demonstrated a significantly increased frequency of allele 2 in patients with CD. AIMS: The purpose of the current study was to determine if a similar association between allele 2 and CD exists in an American population from Dayton, OH...
August 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28459711/a-cross-sectional-analysis-of-minimum-usmle-step-1-and-2-criteria-used-by-orthopaedic-surgery-residency-programs-in-screening-residency-applications
#14
John B Schrock, Matthew J Kraeutler, Michael R Dayton, Eric C McCarty
INTRODUCTION: The purpose of this study was to analyze how program directors (PDs) of orthopaedic surgery residency programs use United States Medical Licensing Examination (USMLE) Step 1 and 2 scores in screening residency applicants. METHODS: A survey was sent to each allopathic orthopaedic surgery residency PD. PDs were asked if they currently use minimum Step 1 and/or 2 scores in screening residency applicants and if these criteria have changed in recent years...
June 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28453717/reaching-the-global-target-to-reduce-stunting-an-investment-framework
#15
Meera Shekar, Jakub Kakietek, Mary R D'Alimonte, Hilary E Rogers, Julia Dayton Eberwein, Jon Kweku Akuoku, Audrey Pereira, Shan Soe-Lin, Robert Hecht
Childhood stunting, being short for one's age, has life-long consequences for health, human capital and economic growth. Being stunted in early childhood is associated with slower cognitive development, reduced schooling attainment and adult incomes decreased by 5-53%. The World Health Assembly has endorsed global nutrition targets including one to reduce the number of stunted children under five by 40% by 2025. The target has been included in the Sustainable Development Goals (SDG target 2.2). This paper estimates the cost of achieving this target and develops scenarios for generating the necessary financing...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28429766/beyond-growth-signaling-paneth-cells-metabolically-support-iscs
#16
Talya L Dayton, Hans Clevers
Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.
July 2017: Cell Research
https://www.readbyqxmd.com/read/28429136/is-there-an-alternative-treatment-for-patients-intolerant-to-antiplatelet-therapy-if-percutaneous-left-atrial-appendage-closure-is-considered
#17
F Akca, N J Verberkmoes, S E Verstraeten, C van Laar, B P van Putte, A H M van Straten
INTRODUCTION: Left atrial appendage (LAA) closure has become of major interest for patients with atrial fibrillation intolerant to oral anticoagulation therapy (OAC). Patients with a contraindication to both OAC and antiplatelet therapy are not eligible for percutaneous LAA closure. We aimed to find an alternative treatment for these specific patients. METHODS: From March 2014 until December 2015 five patients were referred for percutaneous LAA closure. Alternative treatment was necessary due to an absolute contraindication to OAC and antiplatelet therapy (n = 4) or after previous failed percutaneous device implantation (n = 1)...
April 20, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28425621/p53-competent-cells-and-p53-deficient-cells-display-different-susceptibility-to-oxygen-functionalized-graphene-cytotoxicity-and-genotoxicity
#18
Dayton M Petibone, Thikra Mustafa, Shawn E Bourdo, Andersen Lafont, Wei Ding, Alokita Karmakar, Zeid A Nima, Fumiya Watanabe, Daniel Casciano, Suzanne M Morris, Vasily N Dobrovolsky, Alexandru S Biris
Due to the distinctive physical, electrical, and chemical properties of graphene nanomaterials, numerous efforts pursuing graphene-based biomedical and industrial applications are underway. Oxidation of pristine graphene surfaces mitigates its otherwise hydrophobic characteristic thereby improving its biocompatibility and functionality. Yet, the potential widespread use of oxidized graphene derivatives raises concern about adverse impacts on human health. The p53 tumor suppressor protein maintains cellular and genetic stability after toxic exposures...
April 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28416968/safety-and-efficacy-of-resistive-polymer-versus-forced-air-warming-in-total-joint-surgery
#19
Melanie F Sandoval, Paul D Mongan, Michael R Dayton, Craig A Hogan
BACKGROUND: Forced-air warming is used as a mechanism to prevent hypothermia and adverse outcomes associated with hypothermia among patients undergoing surgery. Patient safety in healthcare includes the use of devices and technology that minimize potential adverse events to patients. The present study sought to compare the capabilities of patient warming between two different devices that use different mechanisms of warming: forced-air warming and non-air warming. METHODS: One hundred twenty patients undergoing total hip or total knee arthroplasty received patient warming via a forced warming device or non-air warming fabric conductive material...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28401845/parent-child-intervention-decreases-stress-and-increases-maternal-brain-activity-and-connectivity-during-own-baby-cry-an-exploratory-study
#20
James E Swain, S Shaun Ho, Katherine L Rosenblum, Diana Morelen, Carolyn J Dayton, Maria Muzik
Parental responses to their children are crucially influenced by stress. However, brain-based mechanistic understanding of the adverse effects of parenting stress and benefits of therapeutic interventions is lacking. We studied maternal brain responses to salient child signals as a function of Mom Power (MP), an attachment-based parenting intervention established to decrease maternal distress. Twenty-nine mothers underwent two functional magnetic resonance imaging brain scans during a baby-cry task designed to solicit maternal responses to child's or self's distress signals...
May 2017: Development and Psychopathology
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