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https://www.readbyqxmd.com/read/29901410/continuous-glucose-monitoring-glycemic-variability-and-excessive-fetal-growth-in-pregnancies-complicated-by-type-1-diabetes
#1
Bethany M Mulla, Nudrat Noor, Tamarra James-Todd, Elvira Isganaitis, Tamara C Takoudes, Ashley Curran, Celestine E Warren, Karen E O'Brien, Florence M Brown
BACKGROUND: To examine trimester-specific associations among glycemic variability, fetal growth, and birthweight in pregnancies with type 1 diabetes mellitus (Type 1 DM). METHODS: In this retrospective cohort study of 41 pregnant women with Type 1 DM, we used continuous glucose monitoring (CGM) data to calculate glycemic variability (coefficient of variation of glucose) over a 7-day interval in each trimester. Clinical data, including fetal biometry, birthweight, and perinatal complications, were extracted from medical records...
June 14, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29896442/sonographic-estimated-fetal-weight-among-diabetics-at-%C3%A2-34-weeks-and-composite-neonatal-morbidity
#2
Leen Al-Hafez, Michael L Pirics, Suneet P Chauhan
Objectives  The objective was to assess the composite neonatal morbidity (CNM) among diabetic women with sonographic estimated fetal weight (SEFW) at 10 to 90th versus >90th percentile for gestational age (GA). Study Design  The inclusion criteria for this retrospective study were singleton pregnancies at 34 to 41 weeks, complicated by diabetes, and that had SEFW within 4 weeks of delivery. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated. Results  Among the 140 cohorts that met the inclusion criteria, 72% had SEFW at 10th to 90th percentile for GA, and 28% at >90th percentile...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29886811/an-integrated-model-with-classification-criteria-to-predict-vaginal-delivery-success-after-cesarean-section
#3
Sebastian Manzanares, Susana Ruiz-Duran, Andrea Pinto, Alicia Pineda, Alberto Puertas, Sebastian Manzanares
BACKGROUND: Cesarean delivery (CD) is the most frequently performed surgical procedure worldwide. Trial of labor after cesarean (TOLAC) is associated with an increase in perinatal complications related to uterine rupture. However, in general, vaginal birth after cesarean (VBAC) is considered safe and women have less morbidity than those who undergo an elective repeat cesarean delivery. OBJECTIVE: To develop an integrated model with the best performance criteria for predicting vaginal delivery success after cesarean delivery...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29879924/is-birth-weight-the-major-confounding-factor-in-the-study-of-gestational-weight-gain-an-observational-cohort-study
#4
Amy C O'Higgins, Anne Doolan, Thomas McCartan, Laura Mullaney, Clare O'Connor, Michael J Turner
BACKGROUND: Much interest has been focussed on both maternal obesity and gestational weight gain (GWG), particularly on their role in influencing birth weight (BW). Several large reviews have reported that excessive GWG is associated with an increase in BW. However recent large, well-designed, randomized controlled trials studying interventions aimed at reducing GWG have all consistently failed to show a reduction in BW despite achieving a reduction in GWG. The aim of this longitudinal prospective study was to examine the relationship between GWG and birth weight in women where GWG and Body Mass Index (BMI) were measured accurately in a strictly standardized way...
June 7, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29879462/pravastatin-l-arginine-combination-improves-umbilical-artery-blood-flow-and-neonatal-outcomes-in-dichorionic-twin-pregnancies-through-an-nitric-oxide-dependent-vasorelaxant-effect
#5
Aleksandar Jurisic, Zaklina Jurisic, Eleftheria Lefkou, Joaquim Pombo, Guillermina Girardi
The increase in fetal and neonatal morbidity and mortality associated with twin pregnancies correlates with an increased risk of preterm delivery, low birth weight, and intrauterine growth restriction (IUGR). Although the pathogenesis of IUGR is unclear and thus management remains a major challenge, feto-placental blood vessels are compromised, and altered umbilical blood flow is observed. In this pilot observational study we investigated the effects of pravastatin plus l-arginine on umbilical artery (umb art) blood flow...
June 4, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29878301/customized-fetal-growth-standard-compared-to-the-intergrowth-21st-century-standard-at-predicting-small-for-gestational-age-neonates
#6
Anthony O Odibo, Chinedu Nwabuobi, Linda Odibo, Karla Leavitt, Sarah Obican, Methodius G Tuuli
INTRODUCTION: The Intergrowth-21st project (IG-21) was recently performed aiming to provide a universal benchmark for comparing fetal growth across different ethnicities. Our aim was to compare the IG-21 with a customized standard for predicting pregnancies at risk for neonatal small for gestational age (SGA) and adverse outcomes. MATERIAL AND METHODS: This was a prospective cohort study including singleton pregnancies presenting for fetal growth assessment between 26 and 36 weeks gestation...
June 7, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29851029/placental-growth-factor-as-an-indicator-of-fetal-growth-restriction-in-late-onset-small-for-gestational-age-pregnancies
#7
Ngaire Anderson, Monique De Laat, Samantha Benton, Peter Dadelszen, Lesley McCowan
BACKGROUND: At-risk small-for-gestational age (SGA) pregnancies in New Zealand are identified using Doppler ultrasound; fetuses with Doppler abnormalities are considered growth restricted (FGR). Low maternal placental growth factor (PlGF) has also been associated with late-onset FGR. AIMS: To investigate whether low PlGF at diagnosis of late-onset SGA identifies the same fetuses classified FGR by detailed Doppler studies, and the association between low PlGF and adverse pregnancy outcomes...
May 31, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29844941/current-knowledge-on-the-use-of-ultrasound-measurements-of-fetal-soft-tissues-for-the-assessment-of-pregnancy-development
#8
REVIEW
Aleksandra Warska, Anna Maliszewska, Anna Wnuk, Beata Szyszka, Włodzimierz Sawicki, Krzysztof Cendrowski
Ultrasonography, with its detailed imaging of the fetus, is very widely used in obstetrics. The primary aim of ultrasound scanning in pregnancy is to limit the risk of obstetric complications by early detection of abnormalities, such as intrauterine growth restriction and macrosomia. Currently, morphometric formulae are used for estimating fetal weight. They utilize basic biometric parameters. However, Hadlock formula, used for fetal weight estimation, has an error rate of 20%. For this reason, researchers all over the world have been looking for other sonographic parameters correlating with fetal weight, with a higher predictive value...
March 2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29844937/utility-of-doppler-parameters-at-36-42-weeks-gestation-in-the-prediction-of-adverse-perinatal-outcomes-in-appropriate-for-gestational-age-fetuses
#9
Michał Migda, Katarzyna Gieryn, Bartosz Migda, Marian Stanisław Migda, Marek Maleńczyk
Aim: To investigate the potential value of Doppler ultrasound and to assess cerebroplacental ratio (CPR) in the prediction of adverse perinatal outcome defined as Apgar score < 7 at 1 minute. Material and methods: This was a retrospective cross-sectional study in selected pregnant women undergoing an ultrasound examination between 36 and 42 weeks of gestation. We measured estimated fetal weight (EFW), mean umbilical artery pulsatility index (UA PI), mean middle cerebral artery pulsatility index (MCA PI), CPR, and Apgar score in 1 minute...
March 2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29813118/maternal-height-and-risk-of-caesarean-section-in-singleton-births-in-sweden-a-population-based-study-using-data-from-the-swedish-pregnancy-register-2011-to-2016
#10
Ingrid Mogren, Maria Lindqvist, Kerstin Petersson, Carin Nilses, Rhonda Small, Gabriel Granåsen, Kristina Edvardsson
Caesarean section (CS) has short and long term adverse health consequences, and should therefore only be undertaken when necessary. Risk factors such as maternal age, maternal body mass index (BMI) and fetal weight have been extensively investigated in relation to CS, but the significance of maternal height has been less explored in Sweden. The aim was to investigate the significance of maternal height on risk of CS in a representative, population-based sample from Sweden, also taking into account confounders...
2018: PloS One
https://www.readbyqxmd.com/read/29803819/fetal-growth-velocity-the-nichd-fetal-growth-studies
#11
Katherine L Grantz, Sungduk Kim, William A Grobman, Roger Newman, John Owen, Daniel Skupski, Jagteshwar Grewal, Edward K Chien, Deborah A Wing, Ronald J Wapner, Angela C Ranzini, Michael P Nageotte, Stefanie N Hinkle, Sarah Pugh, Hanyun Li, Karin Fuchs, Mary Hediger, Germaine M Buck Louis, Paul S Albert
BACKGROUND: Accurately identifying pregnancies with accelerated or diminished fetal growth is challenging and generally based on cross-sectional percentile estimates of fetal weight. Longitudinal growth velocity might improve identification of abnormally grown fetuses. OBJECTIVES: To complement fetal size standards with fetal growth velocity, develop a model to compute fetal growth velocity percentiles for any given set of gestational week intervals, and determine association between fetal growth velocity and birthweight...
May 24, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29793556/examination-of-the-association-of-physical-activity-during-pregnancy-after-cesarean-delivery-and-vaginal-birth-among-chinese-women
#12
Xin-Ying Qi, Yan-Ping Xing, Xue-Zhen Wang, Feng-Zhen Yang
BACKGROUND: The goal was to study whether higher physical activity can increase the success rate of Vaginal Birth after Cesarean Delivery (VBAC). METHODS: We enrolled 823 patients with previous cesarean section delivery history (between January 2015 and December 2017) and measured their physical activity during pregnancy. A final number of 519 patients were included for the trial of labor after cesarean delivery (TOLAC). All patients signed informed consent forms...
May 24, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29791899/national-practice-patterns-for-prenatal-monitoring-in-gastroschisis-gastroschisis-outcomes-of-delivery-good-provider-survey
#13
Ruchi Amin, Aaron Domack, Joseph Bartoletti, Erika Peterson, Britton Rink, Jennifer Bruggink, Melissa Christensen, Anthony Johnson, William Polzin, Amy J Wagner
BACKGROUND: Gastroschisis is an abdominal wall defect with increasing incidence. Given the lack of surveillance guidelines among maternal-fetal medicine (MFM) specialists, this study describes current practices in gastroschisis management. MATERIALS AND METHODS: An online survey was administered to MFM specialists from institutions affiliated with the North American Fetal Therapy Network (NAFTNet). Questions focused on surveillance timing, testing, findings that changed clinical management, and delivery plan...
May 23, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29788126/characterizing-the-acute-heat-stress-response-in-gilts-ii-assessing-repeatability-and-association-with-fertility
#14
Kody L Graves, Jacob T Seibert, Aileen F Keating, Lance H Baumgard, Jason W Ross
Mitigating heat stress (HS) in swine production is important as it detrimentally affects multiple aspects of overall animal production efficiency. Study objectives were to determine if gilts characterized as tolerant (TOL) or susceptible (SUS) in response to HS maintain that phenotype later in life and if that phenotype influences reproductive ability during HS. Individual gilts identified as TOL (n = 50) or SUS (n = 50) from a prepubertal HS challenge were selected based on their rectal temperature (TR) during acute HS...
May 16, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29785058/effects-of-maternal-obstructive-sleep-apnea-on-fetal-growth-a-case-control-study
#15
Anna W Kneitel, Marjorie C Treadwell, Louise M O'Brien
OBJECTIVE: To investigate whether maternal obstructive sleep apnea (OSA) is associated with changes in fetal growth trajectory. STUDY DESIGN: Retrospective review of pregnant women who underwent overnight polysomnography. Fetal growth was estimated using sonographic biometric measurements obtained during routine prenatal care. Customized estimated fetal weight and birth weight centiles were calculated and impaired fetal growth was defined as birth weight <10th centile or a slowing of fetal growth by >33% during the last trimester...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29782075/the-mediating-effects-of-gestational-diabetes-on-fetal-growth-and-adiposity-in-women-who-are-overweight-and-obese-secondary-analysis-of-the-limit-randomised-trial
#16
Amanda J Poprzeczny, Jennie Louise, Andrea R Deussen, Jodie M Dodd
OBJECTIVE: to describe the mediating effect of maternal gestational diabetes on fetal biometry and adiposity measures among overweight or obese pregnant women. DESIGN: Secondary analysis of the LIMIT randomised trial. SETTING: Public hospitals, metropolitan Adelaide, South Australia. POPULATION: Pregnant women with body mass index (BMI) ≥25 kg/m2 , and singleton gestation. METHODS: Fetal ultrasound measures at 36 weeks' gestation and baseline BMI from women randomised to the LIMIT trial Standard Care group (n = 912 women) were used to conduct causal mediation analyses using regression-based methods...
May 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29780772/the-trends-and-risk-factors-to-predict-adverse-outcomes-in-gestational-diabetes-mellitus-a-10-year-experience-from-2006-to-2015-in-a-single-tertiary-center
#17
Minji Kim, Juyoung Park, Soo Hyun Kim, Yoo Min Kim, Cheonga Yee, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh
Objective: To investigate the change of maternal characteristics, delivery and neonatal outcomes in gestational diabetes mellitus (GDM) over recent 10 years and to identify the risk factors associated with adverse outcome. Methods: Consecutive GDM patients (n=947) delivered in our institution were included. Research period was arbitrarily divided into 2 periods (period 1: from 2006 to 2010, period 2: from 2011 to 2015). Multiple pregnancies or preexisting diabetes were excluded...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29779410/personalized-charts-for-the-fetal-corpus-callosum-length
#18
Abraham Tsur, Boaz Weisz, Orgad Rosenblat, Daniel Shai, Estela Derazne, David K Stevenson, Reuven Achiron, Eldad Katorza
OBJECTIVE: To personally customize the antenatal ultrasound charts for the fetal corpus callosum (CC) length. METHODS: A retrospective analysis of fetal neuro-sonography scans. Cases were grouped as normal neuro-sonographic evaluation (normal) or as high risk and suspected brain anomaly (abnormal). The normal group was subcategorized according to Cignini's CC length charts. Data of fetuses with a CC length between the 5th-95th percentile served for creating new charts, describing the ratio of the CC length to the major biometric parameters as a function of gestational age (GA)...
May 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29778069/differential-correlations-between-maternal-hair-levels-of-tobacco-and-alcohol-with-fetal-growth-restriction-clinical-subtypes
#19
Sally Sabra, Ebba Malmqvist, Laura Almeida, Eduard Gratacos, Maria Dolores Gomez Roig
Maternal exposure to tobacco and alcohol is a known cause, among others, for fetal growth restriction (FGR). Clinically, FGR can be subclassified into two forms: intrauterine growth restriction (IUGR) and small for gestational age (SGA), based on the severity of the growth retardation, and abnormal uterine artery Doppler or cerebro-placental ratio. This study aimed at investigating any differential correlation between maternal exposures to these toxins with the two clinical forms of FGR. Therefore, a case-control study was conducted in Barcelona, Spain...
January 4, 2018: Alcohol
https://www.readbyqxmd.com/read/29759106/stage-specific-feed-intake-restriction-differentially-regulates-placental-traits-and-proteome-of-goats
#20
Qiongxian Yan, Juanzhi Xu, Xiaosong Wu, Dingding Su, Zhiliang Tan
A total of twenty-four healthy twin-bearing Liuyang black goats were allocated to two trials. In Trial 1, twelve goats received either the control diet (CG, n 6, 100 % feed) or restricted diet (RG, n 6, 60 % feed of CG) from gestation days 26 to 65 after synchronisation. In Trial 2, the remaining goats were randomly and equally divided into two treatments: CG and RG from days 95 to 125 of gestation. Placental traits, fetal weight, serum parameters, nitric oxide (NO), angiogenesis gene expression and cotyledon proteome were measured at the end of each trial...
May 2018: British Journal of Nutrition
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