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https://www.readbyqxmd.com/read/28523122/sex-differences-in-rat-placental-development-from-pre-implantation-to-late-gestation
#1
J I Kalisch-Smith, D G Simmons, M Pantaleon, K M Moritz
BACKGROUND: A male fetus is suggested to be more susceptible to in utero and birth complications. This may be due in part to altered morphology or function of the XY placenta. We hypothesised that sexual dimorphism begins at the blastocyst stage with sex differences in the progenitor trophectoderm (TE) and its derived trophoblast lineages, as these cells populate the majority of cell types within the placenta. We investigated sex-specific differences in cell allocation in the pre-implantation embryo and further characterised growth and gene expression of the placental compartments from the early stages of the definitive placenta through to late gestation...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28514879/growth-restriction-identifying-fetuses-at-risk
#2
Heidi K Leftwich, Bethany Stetson, Bethany Sabol, Katherine Leung, Judith U Hibbard, Isabelle Wilkins
PURPOSE: Examine risks of intrauterine growth restriction (IUGR) and composite perinatal outcomes with estimated fetal weights (EFW) 10-20(th)%, and compare outcomes using umbilical artery Doppler (UAD). MATERIALS AND METHODS: Retrospective, cohort evaluating ultrasound (US) EFW 10th-20(th)%, between 2002-2012. Cases were identified with EFW % 10-20. Controls, EFW >20(th)% were obtained for each case, matched by gestational age and US date. Unadjusted and adjusted logistic regression was used for outcomes...
May 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28510096/birth-weight-and-its-relation-with-medical-nutrition-therapy-in-gestational-diabetes
#3
Marianne Vestgaard, Allan Stubbe Christensen, Lone Viggers, Finn Friis Lauszus
PURPOSE: The cornerstone in treatment of gestational diabetes mellitus (GDM) is medical nutrition therapy (MNT), but the effect on birth weight is disputed. The birth weight was evaluated with respect to length of MNT and adherence to diet. METHODS: We performed a cohort study on 436 women with GDM and 254 non-diabetic women. Women with a normal oral glucose tolerance test were included as controls as they had similar background predisposition as the women with GDM...
May 16, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28509414/the-normal-fetal-pancreas
#4
Zvi Kivilevitch, Reuven Achiron, Sharon Perlman, Yinon Gilboa
OBJECTIVES: The aim of the study was to assess the sonographic feasibility of measuring the fetal pancreas and its normal development throughout pregnancy. METHODS: We conducted a cross-sectional prospective study between 19 and 36 weeks' gestation. The study included singleton pregnancies with normal pregnancy follow-up. The pancreas circumference was measured. The first 90 cases were tested to assess feasibility. RESULTS: Two hundred ninety-seven fetuses of nondiabetic mothers were recruited during a 3-year period...
May 16, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28508694/online-versus-offline-spatiotemporal-image-correlation-stic-m-mode-for-the-evaluation-of-cardiac-longitudinal-annular-displacement-in-fetal-growth-restriction
#5
Jozien C Tanis, Nuruddin Mohammed, Mar Bennasar, Josep Maria Martinez, Bart Bijnens, Fatima Crispi, Eduard Gratacos
PURPOSE: Our first aim was to compare online M-mode with offline spatiotemporal image correlation (STIC) M-mode for assessing longitudinal annular displacement (LAD) in growth restricted fetuses (FGR). Our second aim was to compare LAD measures of FGR cases with controls. MATERIALS AND METHODS: Prospective study including 40 FGR cases (defined estimated fetal weight and birth weight <10(th) centile) and 72 normally grown fetuses matched to cases by gestational age at scan...
May 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28508549/prenatal-prediction-of-postnatal-large-for-date-neonates-using-a-simplified-method-at-mr-imaging-comparison-with-conventional-2d-ultrasound-estimates
#6
Caroline Kadji, Mieke M Cannie, Ricardo De Angelis, Margaux Camus, Magdalena Klass, Stéphanie Fellas, Vera Cecotti, Vivien Dütemeyer, Jacques C Jani
PURPOSE: To evaluate the performance of a simple method of estimating fetal weight (EFW) using MR imaging as compared with 2D US in the prediction of large-for-date neonates. MATERIALS & METHODS: Written informed consent was obtained for this EC-approved study. Between March 2011 and May 2016, 2 groups of women with singleton pregnancies were evaluated: women that underwent US-EFW and MR-EFW within 48 h before delivery and those undergoing these evaluations between 35 + 0 weeks and 37 + 6 weeks of gestation...
May 15, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28507483/effects-of-hesperidin-on-formaldehyde-induced-toxicity-in-pregnant-rats
#7
Sameha Merzoug, Mohamed Lamine Toumi
This experimental study aimed to investigate the protective effect of a bioflavonoid, hesperidin (HP), on formaldehyde (FA)-related pathophysiological and behavioral outcomes in pregnant rats and developmental aspects in their offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). Pregnant rats were weighed throughout gestation and tested in two behavioral paradigms (elevated plus-maze and open field) at gestational days (GD) 1, 10 and 19 to evaluate the anxiety-like behavior and locomotive alterations...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28498795/comparison-of-fetal-weight-distribution-improved-by-paternal-height-by-spanish-standard-versus-intergrowth-21st-standard
#8
Ricardo Savirón-Cornudella, Luis Mariano Esteban, Diego Lerma, Laura Cotaina, Ángel Borque, Gerardo Sanz, Sergio Castán
OBJECTIVE: Our main objective was to study the influence on birth and ultrasound fetal weight of traditional factors in combination with non-traditionally explored predictors such as paternal height to provide a new customized in utero growth model. We also have compared it in our population with other customized and non-customized models. METHODS: We collected 5243 cases of singleton pregnancies. An integrated study of the different variables was performed in a multivariate model to predict the fetus birthweight and customized growth curves were created following the Gardosi procedure...
May 12, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28485827/correlation-between-pre-pregnancy-body-mass-index-and-maternal-visceral-adiposity-with-fetal-biometry-during-the-second-trimester
#9
Karina Rm Lopes, Alex Sandro R Souza, José N Figueiroa, João Guilherme B Alves
OBJECTIVE: To determine the correlation between pre-pregnancy body mass index (BMI) and maternal visceral adiposity with fetal biometry during the second trimester. METHODS: A cross-sectional observational study was conducted among pregnant women who received prenatal care at a center in Recife, Brazil, between October 3, 2011, and September 27, 2013. Pre-pregnancy BMI was determined at the first prenatal care visit. Maternal visceral adiposity and fetal biometry were measured at the same ultrasonography session...
May 9, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28467759/nucleated-red-blood-cells-as-a-marker-of-acute-and-chronic-fetal-hypoxia-in-a-rat-model
#10
Victoria K Minior, Brian Levine, Asaf Ferber, Seth Guller, Michael Y Divon
OBJECTIVE: To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. METHODS: Pregnant rats were exposed to a severe hypoxia (9.5%-10% O2) for varying time intervals (2, 6, 12, 24, 48, and 120 hours; n=4 for each time interval) immediately prior to delivery at term. Normoxic controls were exposed to room air (21% O2) and matched for all other study variables (n=4 rats for each time interval). Pups were delivered via hysterotomy while maintaining exposure gas concentrations...
April 28, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28454691/fetal-dna-does-not-induce-preeclampsia-like-symptoms-when-delivered-in-late-pregnancy-in-the-mouse
#11
Jozef Čonka, Barbora Konečná, Lucia Lauková, Barbora Vlková, Peter Celec
INTRODUCTION: The etiology of preeclampsia is unclear. Fetal DNA is present in higher concentrations in the plasma of pregnant women suffering from preeclampsia than in the plasma of healthy pregnant women. A previously published study has shown that human fetal DNA injected into pregnant mice induces preeclampsia-like symptoms when administered between gestation days 10-14. The aim of our experiment was to determine whether or not similar effects would be induced by administration of human and mouse fetal DNA, as well as mouse adult DNA and lipopolysaccharide during late pregnancy in the mouse...
April 2017: Placenta
https://www.readbyqxmd.com/read/28454690/placental-soluble-fms-like-tyrosine-kinase-expression-in-small-for-gestational-age-infants-and-risk-for-adverse-outcomes
#12
Melissa Spiel, Saira Salahuddin, Elizabeth Pernicone, Zsuzsanna Zsengeller, Alice Wang, Anna M Modest, S Ananth Karumanchi, Jonathan L Hecht
INTRODUCTION: Soluble fms-like tyrosine kinase 1 (sFLT-1) is an anti-angiogenic factor implicated in the pathogenesis of preterm preeclampsia. We evaluated sFLT-1 expression and placental pathology in pregnancies complicated by small for gestational age (SGA) infants (<10th percentile), without evidence of preeclampsia. METHODS: Clinical and histologic data were compared between groups with high or low sFLT-1 expression determined by immunohistochemistry on archived placentas...
April 2017: Placenta
https://www.readbyqxmd.com/read/28452133/blinded-ultrasonic-fetal-biometry-at-36-weeks-and-the-risk-of-emergency-caesarean-delivery-a-prospective-cohort-study-of-3-047-low-risk-nulliparous-women
#13
Ulla Sovio, Gordon C S Smith
OBJECTIVES: We studied the risk of emergency caesarean delivery (CD) using blinded ultrasonographic estimated fetal weight (EFW) at 36 weeks of gestational age (wkGA): (1) to compare the association for customised and non-customised EFW, (2) to determine whether adding ultrasonic EFW improved prediction based on maternal characteristics alone, and (3) to determine whether women at high predicted risk of emergency CD had higher risks of maternal and perinatal morbidity than other women...
April 28, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28452092/prospective-assessment-of-the-intergrowth-21-and-who-estimated-fetal-weight-reference-curve
#14
Yvonne Kwun Yue Cheng, Jing Lu, Tak Yeung Leung, Yiu Man Chan, Daljit Singh Sahota
OBJECTIVES: To assess the suitability of the new INTERGROWTH-21 and WHO estimated fetal weight (EFW) references. METHODS: This was a prospective cross-sectional cohort study. Viable singleton pregnancies at 11-13 weeks were randomized to undergo a standardized fetal biometric scan after 20 weeks. EFW were predicted using both the Hadlock and INTERGROWTH-21 weight estimation models formulaes. Population specific EFW gestation references were constructed. Z-scores were used to compare the population specific reference against the two international size references, INTERGROWTH-21 and WHO...
April 28, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28451553/feed-forward-control-nursing-model-in-expectant-treatment-of-placenta-previa
#15
Yanfei Zhu, Shuxuan Zhang, Wenxian Shan, Ming Hu
BACKGROUND: We studied the possible advantages of feed-forward control nursing model in the treatment of placenta previa. METHODS: We enrolled 60 pregnant women who were receiving treatment for expectant placenta previa between January 2010 and January 2016 and randomly divided them into the control group and the observation group with 30 cases in each group. In the control group, we offered specialist nursing which included examination, body positioning, vaginal bleeding record, psychological consultation and medication observation...
February 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28440694/fine-particulate-matter-pm2-5-a-risk-factor-of-rat-gestational-diabetes-with-altered-blood-glucose-and-pancreatic-glut2-expression
#16
Liu Yi, Chen Wei, Wang Fan
Recent studies have shown an association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter 2 (GLUT2) expression and its related mechanisms in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose while the controls received saline. Interleukin-6 (IL-6) and blood routine tests (BRT) were detected for analyzing coagulation and inflammation. Pancreas tissues underwent pathologic examination, the levels of homogenate glutathione peroxidase (GSH-Px), and methane dicarboxylic aldehyde (MDA) were detected for oxidative stress estimation, and the degree of GLUT2 expression of pancreas was analyzed...
April 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28439966/automated-fractional-limb-volume-measurements-improve-the-precision-of-birth-weight-predictions-in-late-third-trimester-fetuses
#17
Lauren M Mack, Sung Yoon Kim, Sungmin Lee, Haleh Sangi-Haghpeykar, Wesley Lee
OBJECTIVES: Fetal soft tissue can be assessed by using fractional limb volume as a proxy for in utero nutritional status. We investigated automated fractional limb volume for rapid estimate fetal weight assessment. METHODS: Pregnant women were prospectively scanned for 2- and 3-dimensional fetal biometric measurements within 4 days of delivery. Performance of birth weight prediction models was compared: (1) Hadlock (Am J Obstet Gynecol 1985; 151:333-337; biparietal diameter, abdominal circumference, and femur diaphysis length); and (2) Lee (Ultrasound Obstet Gynecol 2009; 34:556-565; biparietal diameter, abdominal circumference, and automated fractional limb volume)...
April 25, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28439425/fetal-biometric-parameters-reference-charts-for-a-non-selected-risk-population-from-uberaba-brazil
#18
Alberto Borges Peixoto, Taciana Mara Rodrigues da Cunha Caldas, Fernando Felix Dulgheroff, Wellington P Martins, Edward Araujo Júnior
OBJECTIVE: To establish reference charts for fetal biometric parameters in a non-selected risk population from Uberaba, Southeast of Brazil. METHODS: A retrospective cross-sectional study was performed among 5656 non-selected risk singleton pregnant women between 14 and 41 weeks of gestation. The ultrasound exams were performed during routine visits of second and third trimesters. Biparietal diameter (BPD) was measured at the level of the thalami and cavum septi pellucidi...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28436166/perinatal-loss-at-term-the-role-of-uteroplacental-and-fetal-doppler-assessment
#19
Caitriona Monaghan, Julia Binder, Baskaran Thilaganathan, José Morales-Roselló, Asma Khalil
OBJECTIVE: To examine the association of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) on perinatal outcome at term. METHODS: This retrospective cohort study conducted in a single tertiary referral centre included all singleton pregnancies undergoing ultrasound assessment in the third trimester, which subsequently delivered at term. Fetal biometry and Dopplers including the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery were recorded...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28434207/maternal-rates-of-lipolysis-and-glucose-production-in-late-pregnancy-are-independently-related-to-fetal-weight
#20
Barbro Diderholm, Kathryn Beardsall, Peter Murgatroyd, Christoph Lees, Jan Gustafsson, David Dunger
OBJECTIVE: Associations between maternal glucose levels and increased fetal growth are well established and independent relationships with maternal weight, weight gain and insulin resistance are also observed. The relative roles of lipolysis and glucose production in the determination of these observations remain unclear. DESIGN: We examined, through detailed physiological studies, the relationship between maternal late gestational energy substrate production (glucose and glycerol), maternal weight and weight gain, and estimated fetal size in the third trimester...
April 23, 2017: Clinical Endocrinology
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