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https://www.readbyqxmd.com/read/29237307/oligohydramnios-is-an-independent-risk-factor-for-perinatal-morbidity-among-women-with-preeclampsia-who-delivered-preterm
#1
Alex Rabinovich, Keren Holtzman, Ilana Shoham-Vardi, Moshe Mazor, Offer Erez
PURPOSE: Determine the relationship between oligohydramnios and adverse maternal and neonatal outcomes in a unique cohort of preterm preeclamptic patients. MATERIALS AND METHODS: A retrospective matched case control study comparing 81 preterm parturients (28 0/7 and 36 6/7 weeks) with preeclampsia and oligohydramnios to 81 preterm preeclamptic patients with a normal amniotic fluid index (AFI). RESULTS: 4.8 percent of all our preterm preeclamptic patients had oligohydramnios...
December 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29212398/prediction-of-neonatal-respiratory-distress-syndrome-via-pulmonary-artery-doppler-examination
#2
Barış Büke, Emre Destegül, Hatice Akkaya, Deniz Şİmşek, Mert Kazandi
OBJECTIVE: We aimed with this study to evaluate the role of pulmonary artery acceleration time to ejection time ratio (PATET) in the prediction of respiratory distress syndrome (RDS) in preterm neonates. MATERIALS AND METHODS: In this prospective cohort study, 105 singleton pregnant women with no congenital abnormalities and pregnancy complications who delivered before 37 weeks of gestational age were included. All of the patients underwent ultrasound examination to obtain fetal pulmonary artery Doppler 15 patients excluded from the study due to giving birth more than 3 days of ultrasound examination or inadequate Doppler measurements...
December 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29212395/prenatal-prediction-of-small-for-gestational-age-neonates-using-mr-imaging-comparison-with-conventional-2d-ultrasound
#3
Andrew Carlin, Caroline Kadji, Riccardo De Angelis, Mieke M Cannie, Jacques C Jani
PURPOSE: To evaluate the performance of estimating fetal weight (EFW) using magnetic resonance (MR) imaging as compared with two-dimensional (2D) ultrasound (US) in the prediction of small-for-gestational age neonates (SGA). MATERIALS & METHODS: Written informed consent was obtained for this Ethical Committee approved study. Between March 2011 and May 2016, women with singleton pregnancies underwent US-EFW and MR-EFW within 48 h before delivery. US-EFW was based on Hadlock et al...
December 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29199998/machine-learning-for-fetal-growth-prediction
#4
Ashley I Naimi, Robert W Platt, Jacob C Larkin
Birthweight is often used as a proxy for fetal weight. Problems with this practice have recently been brought to light. We explore whether data available at birth can be used to predict estimated fetal weight using linear and quantile regression, random forests, Bayesian additive regression trees, and generalized boosted models. We train and validate each approach using 18,517 pregnancies (31,948 ultrasound visits) from the Magee-Womens Obstetric Maternal and Infant data, and 240 pregnancies in a separate dataset of high-risk pregnancies...
December 1, 2017: Epidemiology
https://www.readbyqxmd.com/read/29199029/the-effect-of-customization-and-use-of-a-fetal-growth-standard-on-the-association-between-birthweight-percentile%C3%A2-and-adverse-perinatal-outcome
#5
Ulla Sovio, Gordon C S Smith
BACKGROUND: It has been proposed that correction of offspring weight percentiles (customization) might improve the prediction of adverse pregnancy outcome; however, the approach is not accepted universally. A complication in the interpretation of the data is that the main method for calculation of customized percentiles uses a fetal growth standard, and multiple analyses have compared the results with birthweight-based standards. OBJECTIVES: First, we aimed to determine whether women who deliver small-for-gestational-age infants using a customized standard differed from other women...
December 1, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29194459/correction-correction-the-world-health-organization-fetal-growth-charts-a-multinational-longitudinal-study-of-ultrasound-biometric-measurements-and-estimated-fetal-weight
#6
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pmed.1002284.].
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29192969/effects-of-applying-universal-fetal-growth-standards-in-a-scandinavian-multi-ethnic-population
#7
Line Sletner, Torvid Kiserud, Siri Vangen, Britt Nakstad, Anne Karen Jenum
INTRODUCTION: The question whether universal growth charts can be used in multi-ethnic settings is of general interest. The Intergrowth-21st (IG-21) fetal growth and newborn size standards are suggested to represent optimal fetal growth regardless of country origin. Our aim was to examine whether women fulfilling the strict IG-21 inclusion criteria were healthier, showed less ethnic differences in fetal growth and newborn size, and less adverse perinatal outcomes. MATERIAL AND METHODS: Data were drawn from a population-based multi-ethnic cohort of 823 presumably healthy pregnant women in Oslo, Norway...
November 28, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29190628/cord-blood-biomarkers-of-cardiac-dysfunction-and-damage-in-term-growth-restricted-fetuses-classified-by-severity-criteria
#8
Míriam Perez-Cruz, Fàtima Crispi, María Teresa Fernández, Johanna Alexandra Parra, Anna Valls, María Dolores Gomez Roig, Eduard Gratacós
OBJECTIVE: To assess cardiovascular function and damage in term small-for-gestational-age (SGA) and intrauterine growth-restricted (IUGR) fetuses by echocardiography and biomarkers in cord blood. METHODS: This was a cohort study including 60 normal fetuses and 47 term small fetuses subclassified as small for gestational age (SGA) with estimated fetal weight (EFW) between the 3rd and 9th centiles and normal fetoplacental Doppler (n = 14) or intrauterine growth restriction (IUGR, n = 33) if EFW <3rd centile or EFW <10th centile together with cerebroplacental ratio <5th and/or mean uterine artery pulsatility index >95th centile...
November 30, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29188582/a-low-birth-weight-infant-with-no-malformations-delivered-by-a-primary-immune-thrombocytopenia-patient-treated-with-eltrombopag
#9
Naruko Suzuki, Junji Hiraga, Yumi Hariyama, Yusuke Takagi, Haruhiko Ohashi, Yasuyuki Kishigami, Hidenori Oguchi, Yoshitoyo Kagami
Primary immune thrombocytopenia (ITP) is defined by a low platelet count secondary to antibody-mediated platelet destruction or reductions in platelet production. Although eltrombopag is a thrombopoietin receptor agonist that increases platelet production in refractory or relapsed ITP, the influence on pregnancy is limited. We present the case of a pregnant 25-year-old ITP patient referred to our hospital with a history of two induced abortions. After eradication of Helicobacter pylori and with oral prednisolone at 8 mg/day, platelet count remained below 10,000/µl...
November 29, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29186930/protective-effects-of-liquiritigenin-against-citrinin-triggered-oxidative-stress-mediated-apoptosis-and-disruption-of-embryonic-development-in-mouse-blastocysts
#10
Chien-Hsun Huang, Wen-Hsiung Chan
The mycotoxin citrinin (CTN), a natural contaminant in foodstuffs and animal feeds, exerts cytotoxic and genotoxic effects on various mammalian cells and embryos. A previous investigation by our group revealed potentially hazardous effects of CTN on mouse oocyte maturation and pre- and post-implantation embryo development via the induction of apoptosis. The present study showed that CTN induces apoptosis and inhibits cell proliferation in the inner cell mass of mouse blastocysts. Notably, we observed for the first time that both these effects are suppressed by liquiritigenin (LQ)...
November 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29183184/third-trimester-ultrasound-for-fetal-macrosomia-optimal-timing-and-institutional-specific-accuracy
#11
Laura I Parikh, Sara N Iqbal, Angie C Jelin, Rachael T Overcash, Eshetu Tefera, Melissa H Fries
PURPOSE: To determine the performance of third trimester ultrasound in women with suspected fetal macrosomia. MATERIALS AND METHODS: We performed a retrospective cohort study of fetal ultrasounds from January 2004 to December 2014 with estimated fetal weight (EFW) between 4000 and 5000 g. We determined accuracy of birth weight prediction for ultrasound performed at less than and greater than 38 weeks, accounting for diabetic status and time between ultrasound and delivery...
November 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29183177/low-apgar-scores-in-term-newborns-and-long-term-gastro-intestinal-morbidity-a-population-based-cohort-study-with-up-to-18%C3%A2-years-of-follow-up
#12
Noa Leybovitz-Haleluya, Tamar Wainstock, Eyal Sheiner, Idit Segal, Daniella Landau, Asnat Walfisch
INTRODUCTION: Low Apgar scores (< 7) measured at age 5 minutes can predict short-term infant morbidity and mortality. Although an association exists between low Apgar scores and neuropsychological disorders, other childhood disorders were not thoroughly studied. We aimed to study the possible association between low 5-minute Apgar scores in term newborns and their long-term childhood gastrointestinal (GI) morbidity. METHODS: A population based cohort analysis was performed comparing total and different subtypes of GI related pediatric hospitalizations among newborns with normal (≥ 7) and low (< 7) 5-minute Apgar scores...
November 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29172821/risk-of-donor-demise-after-laser-therapy-for-twin-twin-transfusion-when-complicated-by-growth-discordance-and-abnormal-umbilical-artery-doppler-findings
#13
Matthew M Finneran, Megan A Templin, Courtney D Stephenson
OBJECTIVE: To investigate the natural course of abnormal umbilical artery Doppler (UAD) findings in donor fetuses after laser surgery and the prognostic significance of resolution, persistence, or new onset UAD abnormalities with and without the presence of preoperative growth discordance. STUDY DESIGN: Retrospective cohort study of all monochorionic-diamniotic multi-fetal gestations diagnosed with twin-twin transfusion syndrome (TTTS) undergoing laser surgery at a single large metropolitan referral center from 2010-2016...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29169715/-perinatal-care-for-extremely-preterm-infants-considerations-of-the-risks-in-pregnancy-department
#14
P-H Jarreau, L Allal, F Autret, E Azria, O Anselem, L Boujenah, C Crenn-Hebert, L Desfrere, G Girard, F Goffinet, C Huon, G Kayem, M-C Lamau, H Legardeur, D Luton, S Menard, J Patkai, M Rajguru-Kasemi, V Tessier
Decisions regarding whether to initiate or forgo intensive care for extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients and must be taken into account. After a short review of these factors, we present the thoughts and proposals of the Risks and Pregnancy department. The proposals are to limit emergency decisions, to better take into account other factors than gestational age and prenatal predicted fetal weight in assessing the prognosis, to introduce multidisciplinary consultation in the evaluation and proposals that will be discussed with the parents, and to separate prenatal steroid therapy from decision-making regarding whether or not to administer intensive care...
November 20, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29168595/berberine-impairs-embryonic-development-in-vitro-and-in-vivo-through-oxidative-stress-mediated-apoptotic-processes
#15
Chien-Hsun Huang, Zi-Wei Huang, Feng-Ming Ho, Wen-Hsiung Chan
Berberine, an isoquinoline alkaloid isolated from several traditional Chinese herbal medicines, has been shown to suppress growth and induce apoptosis in some tumor cell lines. However, berberine has also been reported to attenuate H2 O2 -induced oxidative injury and apoptosis. The basis for these ambiguous effects of berberine-triggering or preventing apoptosis-has not been well characterized to date. In the current investigation, we examined whether berberine exerts cytotoxic effects on mouse embryos at the blastocyst stage and affects subsequent embryonic development in vitro and in vivo...
November 23, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29166205/pregnant-women-with-heart-disease-placental-characteristics-and-their-association-with-fetal-adverse-events
#16
Fabio V Lima, Paraskevi Koutrolou-Sotiropoulou, Puja B Parikh, Cecilia Avila, Javed Butler, Kathleen Stergiopoulos
BACKGROUND: Pregnant women with heart disease (HD) have higher rates of adverse fetal outcomes. We describe placental pathologic characteristics and their association with fetal events. METHODS: In pregnant women, known HD were categorized into: (1) cardiomyopathy (CM) or (2) other HD (congenital, coronary, arrhythmia, or valvular). Outcomes were maternal major adverse cardiac events (MACE), fetal adverse clinical events (FACE), a composite of infant death, prematurity, underweight status, intracranial hemorrhage, and respiratory distress...
September 2016: Acute Cardiac Care
https://www.readbyqxmd.com/read/29161577/histological-characteristics-of-the-gonads-of-pig-fetuses-and-their-relationship-with-fetal-anatomical-measurements
#17
Thais Preisser Pontelo, José Rafael Miranda, Matheus Augusto Rodrigues Felix, Barbara Azevedo Pereira, William Eduardo da Silva, Gleide Fernandes Avelar, Flávia Cristina Martins Queiroz Mariano, Gregório Corrêa Guimarães, Márcio Gilberto Zangeronimo
The objective was to evaluate the histomorphometric characteristics of the testis and ovaries of pig fetuses at different gestational ages, as well as their correlation with some fetus measurements. Forty-four fetuses were separated for gender (male and female) and gestational age (50, 80 and 106days of gestation). After slaughter, fetuses had their body length, head and thoracic perimeters measured and their gonads submitted to histomorphometric analyses. The gonadal characteristics at different gestational ages were statistically compared, correlations with the fetal measurements were performed and equations to predict the gonadal characteristics from the fetal measurements were obtained...
November 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29142173/effect-of-dibutyltin-on-placental-and-fetal-toxicity-in-rat
#18
Satoshi Furukawa, Naho Tsuji, Yoshiyuki Kobayashi, Yoshikazu Yamagishi, Seigo Hayashi, Masayoshi Abe, Yusuke Kuroda, Masayuki Kimura, Chisato Hayakawa, Akihiko Sugiyama
In order to elucidate the effect of chorioallantoic and yolk sac placenta on the embryonic/fetal toxicity in dibutyltin dichloride (DBTCl)-exposed rats, we examined the histopathological changes and the tissue distribution of dibutyltin in the placentas and embryos. DBTCl was orally administered to the groups at doses of 0 mg/kg during gestation days (GD)s 7-9 (control group) and 20 mg/kg during GDs 7-9 (GD7-9 treated group), and GDs 10-12 (GD10-12 treated group). The total fetal mortality was increased, and malformations characterized by craniofacial dysmorphism were detected in the GD7-9 treated group...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29138223/effect-of-maternal-high-fat-diet-on-key-components-of-the-placental-and-hepatic-endocannabinoid-system
#19
Kushal Gandhi, Cun Li, Nadezhda German, Cezary Skobowiat, Maira Carrillo, Raja Reddy Kallem, Eneko Larumbe, Stacy Martinez, Marcel Chuecos, Gary Ventolini, Peter Nathanielsz, Natalia Schlabritz-Loutsevitch
INTRODUCTION: Involvement of endogenous cannabinoids (eCBs) in obesity is well-characterized. However, information regarding eCB physiology in obesity associated with pregnancy is sparse. METHODS: From at least 9 months before conception, non-pregnant baboons (Papio spp.) were fed a diet of either 45% fat (HFD; n=11) or 12% fat or a control diet (CTR; n=11), and dietary intervention continued through pregnancy. Maternal and fetal venous plasma samples were evaluated using liquid chromatography-mass spectrometry to quantify anandamide (AEA) and 2-arachidonoyl glycerol (2-AG)...
November 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29131898/association-of-maternal-obesity-with-longitudinal-ultrasonographic-measures-of-fetal-growth-findings-from-the-nichd-fetal-growth-studies-singletons
#20
Cuilin Zhang, Mary L Hediger, Paul S Albert, Jagteshwar Grewal, Anthony Sciscione, William A Grobman, Deborah A Wing, Roger B Newman, Ronald Wapner, Mary E D'Alton, Daniel Skupski, Michael P Nageotte, Angela C Ranzini, John Owen, Edward K Chien, Sabrina Craigo, Sungduk Kim, Katherine L Grantz, Germaine M Buck Louis
Importance: Despite the increasing prevalence of pregravid obesity, systematic evaluation of the association of maternal obesity with fetal growth trajectories is lacking. Objective: To characterize differences in fetal growth trajectories between obese and nonobese pregnant women, and to identify the timing of any observed differences. Design, Setting, and Participants: The Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singletons study enrolled cohorts of pregnant women at 12 US health care institutions...
November 13, 2017: JAMA Pediatrics
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