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https://www.readbyqxmd.com/read/27914178/longitudinal-assessment-of-examiner-experience-and-the-accuracy-of-sonographic-fetal-weight-estimation-at-term
#1
Florian Faschingbauer, Jutta Heimrich, Eva Raabe, Sven Kehl, Michael Schneider, Matthias Schmid, Matthias W Beckmann, Tobias Hepp, Anika Lübke, Andreas Mayr, Ralf L Schild
OBJECTIVES: To evaluate the influence of examiner experience on the accuracy of sonographic weight estimation and to further analyze examiners' individual learning curves. METHODS: In this multicenter study, 4613 sonographic weight estimations performed by 18 examiners at the beginning of their ultrasound training were included. To assess the effect of experience on the accuracy of weight estimation, a multivariable mixed regression model analysis was performed, with percentage error and absolute percentage error as outcome variables and the examiner, the examiner's experience (number of examinations), birth weight, gestational age, scan-to-delivery interval, and maternal body mass index as fixed effects and the perinatal center as random intercepts...
December 3, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27902772/relation-between-birth-weight-and-intraoperative-hemorrhage-during-cesarean-section-in-pregnancy-with-placenta-previa
#2
Hiroaki Soyama, Morikazu Miyamoto, Hiroki Ishibashi, Masashi Takano, Hidenori Sasa, Kenichi Furuya
BACKGROUND: Placenta previa, one of the most severe obstetric complications, carries an increased risk of intraoperative massive hemorrhage. Several risk factors for intraoperative hemorrhage have been identified to date. However, the correlation between birth weight and intraoperative hemorrhage has not been investigated. Here we estimate the correlation between birth weight and the occurrence of intraoperative massive hemorrhage in placenta previa. MATERIALS AND METHODS: We included all 256 singleton pregnancies delivered via cesarean section at our hospital because of placenta previa between 2003 and 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27900852/association-of-ultrasound-based-measures-of-fetal-body-composition-with-newborn-adiposity
#3
S Ikenoue, F Waffarn, K Sumiyoshi, M Ohashi, C Ikenoue, C Buss, D L Gillen, H N Simhan, S Entringer, P D Wadhwa
BACKGROUND: Newborns exhibit substantial variation in gestational age-adjusted and sex-adjusted fat mass proportion. The antecedent characteristics of fetal body composition that are associated with newborn fat mass proportion are poorly understood. OBJECTIVE: The aim of this study was to determine whether a composite measure of fetal fat mass is prospectively associated with newborn adiposity. METHODS: In a longitudinal study of 109 low-risk pregnancies, fetal ultrasonography was performed at approximately 12, 20 and 30 weeks gestation...
November 29, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27891325/effect-of-tocopheryl-acetate-on-maternal-cigarette-smoke-exposed-swiss-albino-mice-inbred-fetus
#4
Janardan Chaudhary, Royana Singh, S N Shamal, K Supriya, Mona Srivastava, R S More
INTRODUCTION: Cigarette smoking is worldwide problem which can be correlated with teratogenicity. Tocopheryl acetate plays as an antioxidant against the oxidative stress evolved by cigarette smoke exposure during pregnancy. AIM: To study the effect of maternal exposure to cigarette smoke and Tocopheryl acetate on fetuses of mice. MATERIALS AND METHODS: Pregnant mice randomly assigned to different groups (Group I (control), Group II (Tocopheryl acetate), Group III(soyabean oil used as vehicle for Tocopheryl acetate), Group IV (Cigarette smoke Exposed), Group V (Cigarette smoke exposed plus Tocopheryl acetate) and Group VI(Cigarette smoke exposed plus soyabean oil) were exposed to cigarette smoke 3 times a day for 20 minutes each time and Tocopheryl acetate with dose of 200mg/kg/day in 0...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27871203/predicting-periviable-birthweight-and-survival-bedside-ultrasound-verse-anatomy-scan-gestational-adjusted-age-projection
#5
Nathan A Keller, Craig M Zelig
Objective - Two methods of birthweight prediction in the periviable period: bedside ultrasound proximate to delivery versus gestation-adjusted-projection (GAP) method were compared. Methods - Periviable births were identified over a 6-year period. The GAP method was applied to the estimated fetal weight (EFW) from anatomy scans and the gestational age at delivery to predict birthweight (BW), designated EFWGAP. EFW from the bedside ultrasound (EFWUS) and the EFWGAP were compared to actual BW to calculate absolute values of error in BW estimates...
November 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27871201/first-trimester-reference-centiles-of-fetal-biometry-in-indian-population
#6
Manisha Kumar, Ravi Vajala, Karuna Sharma, Shalini Singh, Ritu Singh, Usha Gupta, J Bhattacharjee
AIMS AND OBJECTIVE: To create crown- rump length (CRL) based biometric chart for fetus in the first trimester among the Indian population. MATERIAL AND METHODS: Cross sectional data were obtained from 400 singleton pregnancies between 11 - 14 weeks gestation with a normal outcome. Linear regression models were constructed; the mean and standard deviation were derived as a function of CRL. RESULTS: There was a positive correlation of CRL with nuchal translucency (NT) (y = 0...
November 21, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27859836/outcome-in-monochorionic-twin-pregnancies-with-selective-intrauterine-growth-restriction-according-to-the-umbilical-artery-doppler-pattern-of-the-smaller-twin-a-systematic-review-and-meta-analysis
#7
REVIEW
Danilo Buca, Giorgio Pagani, Giuseppe Rizzo, Alessandra Familiari, Maria Elena Flacco, Lamberto Manzoli, Marco Liberati, Francesco Fanfani, Giovanni Scambia, Francesco D'Antonio
OBJECTIVE: To explore the outcome of monochorionic (MC) twin pregnancies affected by selective intra-uterine growth restriction (sIUGR) according to the umbilical artery Doppler pattern of the smaller twin. METHODS: Medline, Embase, Cinhal and ClinicalTrials.gov databases (2000-2016) were searched. sIUGR was defined as the presence of one twin with estimated fetal weight and/or abdominal circumference less than 10(th) or 5(th) percentile and classified according to the umbilical artery Doppler flow pattern of the smaller twin (type I: persistently positive, type II: persistently absent/reversed, type III: intermittently absent/reversed)...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27859800/change-in-maternal-cardiac-output-from-pre-conception-to-mid-pregnancy-is-associated-with-birth-weight-in-healthy-pregnancies
#8
Amita A Mahendru, Fung L Foo, Carmel M McEniery, Thomas R Everett, Ian B Wilkinson, Christoph C Lees
OBJECTIVE: Birth weight (BW) is thought to be determined by maternal health, and genetic, nutritional and placental factors; the latter being influenced by anatomical development and perfusion. Maternal cardiovascular changes contribute to uteroplacental perfusion, however they have not been investigated in relation to fetal growth/BW. Our aim was to explore the relationship between maternal cardiovascular adaptation, fetal growth and BW in healthy pregnancies. METHODS: This was a longitudinal prospective study of women planning to conceive a pregnancy...
November 18, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27822346/ultrasonographic-evaluation-of-placental-cord-insertion-at-different-gestational-ages-in-low-risk-singleton-pregnancies-a-predictive-algorithm
#9
F Padula, A S Laganà, S G Vitale, L Mangiafico, L D'Emidio, P Cignini, M Giorlandino, F A Gulino, S Capriglione, C Giorlandino
OBJECTIVE: To evaluate the accuracy of ultrasound in visualizing placental cord insertion (PCI) at different gestational ages in order to recommend the most feasible period during pregnancy to identify it. Secondary aim was to propose a predictive algorithm for PCI visualization. METHODS: We performed a single-center, prospective cohort study. We enrolled patients with singleton low-risk pregnancies who underwent fetal ultrasound scan at different gestational ages...
March 28, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27821667/obeticholic-acid-protects-against-lipopolysaccharide-induced-fetal-death-and-intrauterine-growth-restriction-through-its-anti-inflammatory-activity
#10
Yuan-Hua Chen, Xiao-Guang Hu, Yan Zhou, Zhen Yu, Lin Fu, Gui-Bin Zhang, Qing-Li Bo, Hua Wang, Cheng Zhang, De-Xiang Xu
Farnesoid X receptor (FXR) is expressed in human and rodent placentas. Nevertheless, its function remains obscure. This study investigated the effects of obeticholic acid (OCA), a novel synthetic FXR agonist, on LPS-induced fetal death and intrauterine growth restriction. All pregnant mice except controls were i.p. injected with LPS (100 μg/kg) daily from gestational day (GD) 15 to GD17. Some pregnant mice were orally administered with OCA (5 mg/kg) daily from GD13 to GD17. As expected, placental FXR signaling was activated by OCA...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27821653/maternal-physiologic-renal-pelvis-dilatation-in-pregnancy-sonographic-reference-data
#11
Sahan Udayanga Wadasinghe, Louisa Metcalf, Patricia Metcalf, David Perry
OBJECTIVES: The purpose of this study was to produce sonographic reference data for maternal renal pelvis dilatation in asymptomatic pregnant women. METHODS: A prospective cross-sectional study was undertaken on pregnant women presenting for outpatient obstetric imaging. For each side, the renal length and axial anteroposterior diameter of the renal pelvis were measured. Maternal demographics, gravidity and parity, number of fetuses, and estimated fetal weight (when available) were recorded...
November 7, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27819164/current-trends-in-the-diagnosis-and-management-of-gestational-diabetes-mellitus-in-the-united-states
#12
Brianne E Bimson, Barak M Rosenn, Sara A Morris, Elizabeth B Sasso, Rachelle A Schwartz, Lois E Brustman
OBJECTIVE: To assess current practice patterns among members of the Society for Maternal-Fetal Medicine (SMFM) with respect to the diagnosis and management of gestational diabetes mellitus (GDM). METHODS: A 38 question survey on GDM diagnosis and management was distributed to SMFM members. RESULTS: 2330 SMFM members were surveyed with a 40% response rate. Overall, 90.6% of respondents recommend a 2-step (versus a 1-step) diagnostic test. Cutoff values for the 1-h-50 g glucose challenge test vary from 130-140 mg/dL, but the majority (83%) adopts Carpenter Coustan criteria for the 3-h-100 g oral glucose tolerance test...
November 24, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27817102/curcumin-inhibits-placental-inflammation-to-ameliorate-lps-induced-adverse-pregnancy-outcomes-in-mice-via-upregulation-of-phosphorylated-akt
#13
Jianjun Zhou, Huishuang Miao, Xiujun Li, Yali Hu, Haixiang Sun, Yayi Hou
INTRODUCTION: Excessive inflammation results in adverse pregnancy outcomes, including embryonic resorption, fetal growth restriction, and preeclampsia. This study investigated whether curcumin, a highly safe anti-inflammation drug, had protective effect on lipopolysaccharide (LPS)-treated pregnant mice. METHOD: A mouse model of LPS-induced adverse pregnancy outcomes was generated by daily administering LPS from GD 13.5 to GD 16.5. Curcumin was given from GD 0.5...
November 5, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27814705/maternal-urinary-metabolic-signatures-of-fetal-growth-and-associated-clinical-and-environmental-factors-in-the-inma-study
#14
Léa Maitre, Cristina M Villanueva, Matthew R Lewis, Jesús Ibarluzea, Loreto Santa-Marina, Martine Vrijheid, Jordi Sunyer, Muireann Coen, Mireille B Toledano
BACKGROUND: Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data. METHODS: We used (1)H nuclear magnetic resonance (NMR) spectroscopy to characterize maternal urine samples collected in the INMA birth cohort at the first (n = 412 and n = 394, respectively, in Gipuzkoa and Sabadell cohorts) and third trimesters of gestation (n = 417 and 469)...
November 4, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27811594/effect-of-implementing-a-standardized-shoulder-dystocia-documentation-form-on-quality-of-delivery-notes
#15
Lisa C Zuckerwise, Madison M Hustedt, Heather S Lipkind, Edmund F Funai, Cheryl A Raab, Christian M Pettker
OBJECTIVES: Complete and accurate documentation by the delivering provider in cases of shoulder dystocia is critical for providing clinical information and care to the patient and protecting providers from litigation risks. Standardized forms improve inclusion of certain data elements in the medical record, but the impact on subsequent narrative notes is unknown. We aimed to determine if implementation of a standardized shoulder dystocia documentation form improves obstetric provider written narrative delivery notes...
November 2, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27806942/placental-hypoxia-during-early-pregnancy-causes-maternal-hypertension-and-placental-insufficiency-in-the-hypoxic-guinea-pig-model
#16
Loren P Thompson, Laramie Pence, Gerard Pinkas, Hong Song, Bhanu P Telugu
Chronic placental hypoxia is one of the root causes of placental insufficiencies that result in preeclampsia and maternal hypertension. Chronic hypoxia causes disruption of trophoblast (TB) development, invasion into maternal decidua, and remodeling of maternal spiral arteries. The pregnant guinea pig shares several characteristics with humans such as hemomonochorial placenta, villous subplacenta, deep TB invasion and remodeling of maternal arteries, and is an ideal animal model to study placental development...
November 2, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27804212/international-estimated-fetal-weight-standards-of-the-intergrowth-21-st-project
#17
J Stirnemann, J Villar, L J Salomon, E Ohuma, P Ruyan, D G Altman, F Nosten, R Craik, S Munim, L Cheikh Ismail, F C Barros, A Lambert, S Norris, M Carvalho, Y A Jaffer, J A Noble, E Bertino, M G Gravett, M Purwar, C Victora, R Uauy, Z Bhutta, S Kennedy, A T Papageorghiou
BACKGROUND: Estimated fetal weight (EFW) and fetal biometry are complementary measures to screen for fetal growth disturbances. Our aim was to provide international EFW standards to complement the INTERGROWTH-21(st) Fetal Growth Standards that are available for use worldwide. METHODS: Women with an accurate gestational age assessment, who were enrolled in the prospective, international, multicentre, population-based, Fetal Growth Longitudinal Growth Study (FGLS) and INTERBIO-21(st) Fetal Study (FS), two of the components of the INTERGROWTH-21(st) Project, had ultrasound scans every 5 weeks from 9-14 weeks until 40 weeks' gestation...
November 2, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27804184/diagnostic-accuracy-of-ultrasound-in-detecting-birthweight-discordance-in-twin-pregnancies-a-systematic-review-and-meta-analysis
#18
REVIEW
Martina Leombroni, Marco Liberati, Francesco Fanfani, Giorgio Pagani, Alessandra Familiari, Danilo Buca, Lamberto Manzoli, Giovanni Scambia, Giuseppe Rizzo, Francesco D'Antonio
OBJECTIVES: The primary aim of this systematic review was to ascertain the diagnostic performance of ultrasound in detecting birthweight (BW) discordance in twin pregnancies. METHODS: Medline, Embase and Cinahl databases were searched. Summary estimates of sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR-) and diagnostic odds ratio (DOR) for the predictive accuracy of ultrasound estimated fetal weight (EFW) and abdominal circumference (AC) discordance in detecting actual BW discordance were computed using the hierarchical summary receiver operating characteristic model...
November 2, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27802431/genomic-microarray-in-fetuses-with-early-growth-restriction-a-multicenter-study
#19
Antoni Borrell, Maribel Grande, Eva Meler, Joan Sabrià, Edurne Mazarico, Anna Muñoz, Laia Rodriguez-Revenga, Cèlia Badenas, Francesc Figueras
BACKGROUND: Little information is available about the risk of microdeletion and microduplication syndromes in fetal growth restriction (FGR) with a normal karyotype. OBJECTIVE: To assess the incremental yield of genomic microarray over conventional karyotyping in fetuses with early growth restriction. STUDY DESIGN: Genomic microarray was prospectively performed in fetuses with early growth restriction defined as a fetal weight below the 3rd percentile estimated before 32 weeks of pregnancy, and a normal quantitative fluorescent polymerase chain reaction result...
November 2, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27802270/single-and-serial-fetal-biometry-to-detect-preterm-and-term-small-and-large-for-gestational-age-neonates-a-longitudinal-cohort-study
#20
Adi L Tarca, Edgar Hernandez-Andrade, Hyunyoung Ahn, Maynor Garcia, Zhonghui Xu, Steven J Korzeniewski, Homam Saker, Tinnakorn Chaiworapongsa, Sonia S Hassan, Lami Yeo, Roberto Romero
OBJECTIVES: To assess the value of single and serial fetal biometry for the prediction of small- (SGA) and large-for-gestational-age (LGA) neonates delivered preterm or at term. METHODS: A cohort study of 3,971 women with singleton pregnancies was conducted from the first trimester until delivery with 3,440 pregnancies (17,334 scans) meeting the following inclusion criteria: 1) delivery of a live neonate after 33 gestational weeks and 2) two or more ultrasound examinations with fetal biometry parameters obtained at ≤36 weeks...
2016: PloS One
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