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https://www.readbyqxmd.com/read/28440694/fine-particulate-matter-pm2-5-a-risk-factor-of-rat-gestational-diabetes-with-altered-blood-glucose-and-pancreatic-glut2-expression
#1
Liu Yi, Chen Wei, Wang Fan
Recent studies have shown an association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter 2 (GLUT2) expression and its related mechanisms in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose while the controls received saline. Interleukin-6 (IL-6) and blood routine tests (BRT) were detected for analyzing coagulation and inflammation. Pancreas tissues underwent pathologic examination, the levels of homogenate glutathione peroxidase (GSH-Px), and methane dicarboxylic aldehyde (MDA) were detected for oxidative stress estimation, and the degree of GLUT2 expression of pancreas was analyzed...
April 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28439966/automated-fractional-limb-volume-measurements-improve-the-precision-of-birth-weight-predictions-in-late-third-trimester-fetuses
#2
Lauren M Mack, Sung Yoon Kim, Sungmin Lee, Haleh Sangi-Haghpeykar, Wesley Lee
OBJECTIVES: Fetal soft tissue can be assessed by using fractional limb volume as a proxy for in utero nutritional status. We investigated automated fractional limb volume for rapid estimate fetal weight assessment. METHODS: Pregnant women were prospectively scanned for 2- and 3-dimensional fetal biometric measurements within 4 days of delivery. Performance of birth weight prediction models was compared: (1) Hadlock (Am J Obstet Gynecol 1985; 151:333-337; biparietal diameter, abdominal circumference, and femur diaphysis length); and (2) Lee (Ultrasound Obstet Gynecol 2009; 34:556-565; biparietal diameter, abdominal circumference, and automated fractional limb volume)...
April 25, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28439425/fetal-biometric-parameters-reference-charts-for-a-non-selected-risk-population-from-uberaba-brazil
#3
Alberto Borges Peixoto, Taciana Mara Rodrigues da Cunha Caldas, Fernando Felix Dulgheroff, Wellington P Martins, Edward Araujo Júnior
OBJECTIVE: To establish reference charts for fetal biometric parameters in a non-selected risk population from Uberaba, Southeast of Brazil. METHODS: A retrospective cross-sectional study was performed among 5656 non-selected risk singleton pregnant women between 14 and 41 weeks of gestation. The ultrasound exams were performed during routine visits of second and third trimesters. Biparietal diameter (BPD) was measured at the level of the thalami and cavum septi pellucidi...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28436166/perinatal-loss-at-term-the-role-of-uteroplacental-and-fetal-doppler-assessment
#4
Caitriona Monaghan, Julia Binder, Baskaran Thilaganathan, José Morales-Roselló, Asma Khalil
OBJECTIVE: To examine the association of uterine artery (UtA) Doppler indices and cerebroplacental ratio (CPR) on perinatal outcome at term. METHODS: This retrospective cohort study conducted in a single tertiary referral centre included all singleton pregnancies undergoing ultrasound assessment in the third trimester, which subsequently delivered at term. Fetal biometry and Dopplers including the umbilical artery (UA), middle cerebral artery (MCA) and uterine artery were recorded...
April 24, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28434207/maternal-rates-of-lipolysis-and-glucose-production-in-late-pregnancy-are-independently-related-to-fetal-weight
#5
Barbro Diderholm, Kathryn Beardsall, Peter Murgatroyd, Christoph Lees, Jan Gustafsson, David Dunger
OBJECTIVE: Associations between maternal glucose levels and increased fetal growth are well established and independent relationships with maternal weight, weight gain and insulin resistance are also observed. The relative roles of lipolysis and glucose production in the determination of these observations remain unclear. DESIGN: We examined, through detailed physiological studies, the relationship between maternal late gestational energy substrate production (glucose and glycerol), maternal weight and weight gain, and estimated fetal size in the third trimester...
April 23, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28433732/the-clinical-significance-of-an-estimated-fetal-weight-below-the-10th-centile-a-comparison-of-outcomes-between-5th-versus-5th-9th-centile
#6
Malgorzata Mlynarczyk, Suneet P Chauhan, Hind A Baydoun, Catherine M Wilkes, Kimberly R Earhart, Yili Zhao, Christopher Goodier, Eugene Chang, Nicole M Lee Plenty, E Kaitlyn Mize, Michelle Owens, Shilpa Babbar, Dev Maulik, Emily DeFranco, David McKinney, Alfred Z Abuhamad
BACKGROUND: The association between small for gestational age (SGA; birth weight < 10(th) centile for gestational age) and neonatal morbidity is well established. Yet there is a paucity of data on the relationship between suspected SGA (sonographic estimated fetal weight <10(th) centile), at two thresholds and subsequent neonatal morbidity. OBJECTIVE: The objective of this study was to determine the relationship between sonographic estimated fetal weight (SEFW) < 5(th) centile versus 5-9(th) centile and neonatal morbidity...
April 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28426650/neural-injury-markers-in-intrauterine-growth-restriction-and-their-relation-to-perinatal-outcomes
#7
E Mazarico, E Llurba, R Cumplido, A Valls, J C Melchor, M Iglesias, L Cabero, E Gratacós, Md Gómez Roig
BACKGROUND: The aims of this study were to: (1) compare the concentrations of two neural injury markers, S100B protein and neuron-specific enolase (NSE), in intrauterine growth-restricted fetuses (IUGR) and in fetuses with appropriate growth-for-gestational-age (AGA), and (2) investigate potential relationships between concentrations of these markers, Doppler abnormalities, and adverse perinatal or neonatal outcomes. METHODS: This was a case-controlled, cooperative, prospective study among Spanish Maternal and Child Health Network (Retic SAMID) hospitals...
April 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28425156/universal-versus-selective-ultrasonography-to-screen-for-large-for-gestational-age-infants-and-associated-morbidity
#8
Ulla Sovio, Alexandros A Moraitis, Hilary S Wong, Gordon C S Smith
OBJECTIVE: To compare the diagnostic effectiveness of selective versus universal ultrasonography as a screening test for large for gestational age (LGA) infants, and to determine whether previously described ultrasonic markers of excessive fetal growth could identify which suspected LGA fetuses were at increased risk of neonatal morbidity. METHODS: We analysed data from a prospective cohort study of nulliparous women, the Pregnancy Outcome Prediction study. All women had clinically indicated scans as per routine care...
April 20, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28412995/development-and-validation-of-prediction-models-for-risks-of-complications-in-early-onset-pre-eclampsia-prep-a-prospective-cohort-study
#9
Shakila Thangaratinam, John Allotey, Nadine Marlin, Ben W Mol, Peter Von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Asif Ahmed, Jane Daniels, Jon Deeks, Khaled Ismail, Ann Marie Barnard, Julie Dodds, Sally Kerry, Carl Moons, Richard D Riley, Khalid S Khan
BACKGROUND: The prognosis of early-onset pre-eclampsia (before 34 weeks' gestation) is variable. Accurate prediction of complications is required to plan appropriate management in high-risk women. OBJECTIVE: To develop and validate prediction models for outcomes in early-onset pre-eclampsia. DESIGN: Prospective cohort for model development, with validation in two external data sets. SETTING: Model development: 53 obstetric units in the UK...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28410426/factors-affecting-human-colostrum-fatty-acid-profile-a-case-study
#10
Vassilia J Sinanoglou, Dionisis Cavouras, Theodora Boutsikou, Despina D Briana, Dimitra Z Lantzouraki, Stella Paliatsiou, Paraskevi Volaki, Sotiris Bratakos, Ariadne Malamitsi-Puchner, Panagiotis Zoumpoulakis
The role of maternal colostrum to infant development has been extensively studied and presented. Among the main factors which contribute to breast milk composition are maternal diet, age and body mass index, parity, duration of pregnancy and stage of lactation. This study aims to investigate the potential impact of several factors including demographic (i.e. maternal age and nationality) on the colostrum fatty acid profile. Colostrum was collected the third day postpartum in a Greek maternity hospital. Certain lipid quality indices and fatty acid ratios were estimated and results were statistically processed...
2017: PloS One
https://www.readbyqxmd.com/read/28407631/a-longitudinal-study-on-fetal-weight-estimation-at-third-trimester-of-pregnancy-comparison-of-magnetic-resonance-imaging-and-2-d-ultrasound-predictions
#11
Caroline Kadji, Mieke M Cannie, Morgane Van Wettere, Elisa Bevilacqua, Vivien Dütemeyer, Brigitte Strizek, Joe Khalifé, Xin Kang, Jacques C Jani
OBJECTIVE: To prospectively compare magnetic resonance (MR) estimation of fetal weight (MR-EFW) performed at third trimester with ultrasound (US) estimation of fetal weight (US-EFW) and actual birth weight, and to evaluate factors influencing fetal growth rate near term. METHODS: US-EFW and MR-EFW were calculated at a median of 33.0 and 37.7 weeks of gestation in 37 fetuses and plotted on curve centiles to predict birth weights at 39.3 weeks of gestation. The median absolute relative errors for predicted US-EFW and MR-EFW were calculated...
April 14, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28402512/defective-trophoblast-invasion-underlies-fetal-growth-restriction-and-pre-eclampsia-like-symptoms-in-the-stroke-prone-spontaneously-hypertensive-rat
#12
G Barrientos, M Pussetto, M Rose, A C Staff, S M Blois, J E Toblli
STUDY QUESTION: What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SUMMARY ANSWER: SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction...
April 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28401605/prediction-of-delivering-a-small-for-gestational-age-infant-and-adverse-perinatal-outcome-in-women-with-suspected-pre-eclampsia
#13
Melanie Griffin, Paul T Seed, Suzy Duckworth, Robyn North, Jenny Myers, Lucy Mackillop, Nigel Simpson, Jason Waugh, Dilly Anumba, Louise C Kenny, Christopher W G Redman, Andrew H Shennan, Lucy C Chappell
OBJECTIVE: To evaluate the test performance of 47 biomarkers and ultrasound parameters to predict subsequent delivery of an SGA infant and adverse perinatal outcome in women presenting with suspected preeclampsia. METHODS: In a prospective, multicentre observational study, 47 biomarkers and ultrasound parameters were measured in 397 women presenting with suspected preterm preeclampsia, with the objective of evaluating them as predictors of subsequent delivery of an SGA infant and adverse perinatal outcome...
April 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28397385/reduced-physical-activity-in-pregnancy-reduces-maternal-vascular-resistance-and-improves-fetal-growth
#14
Barbara Vasapollo, Damiano Lo Presti, Giulia Gagliardi, Daniele Farsetti, Grazia Maria Tiralongo, Ilaria Pisani, Gian Paolo Novelli, Herbert Valensise
OBJECTIVE: To test the efficacy of maternal activity restriction in normotensive patients with TVR in the upper limits, evaluating the effect on fetal growth. METHODS: Thirty women were enrolled between 27 and 29 weeks gestation. All patients met the following criteria: normal blood pressure values before and during pregnancy, TVR between 1300 and 1400 dyne sec(-1) cm(-5) , normal fetal Doppler parameters at enrolment, abdominal circumference between the 10th and 25th centile...
April 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28393386/maternal-depressive-symptoms-perceived-stress-and-fetal-growth
#15
William A Grobman, Deborah A Wing, Paul Albert, Sungduk Kim, Jagteshwar Grewal, Constance Guille, Roger Newman, Edward K Chien, John Owen, Mary E D'Alton, Ronald Wapner, Anthony Sciscione, Katherine L Grantz
OBJECTIVES: To determine whether longitudinal fetal growth is altered among pregnant women reporting greater perceived stress or more symptoms of depression. METHODS: This analysis was based on a multicenter longitudinal study of fetal growth. Women were screened at gestational ages of 8 weeks to 13 weeks 6 days for low-risk status and underwent serial sonographic examinations. At each study visit during pregnancy, women were asked to complete the Cohen Perceived Stress Scale (PSS) and Edinburgh Postpartum Depression Survey (EPDS)...
April 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28392581/ultrasound-versus-clinical-examination-to-estimate-fetal-weight-at-term
#16
Jan-Simon Lanowski, Gabriele Lanowski, Cordula Schippert, Kristina Drinkut, Peter Hillemanns, Ismini Staboulidou
Introduction At term, fetal weight estimation is an important factor for decisions about the delivery mode and the timing of labor induction. This study aimed to compare the accuracy of abdominal palpation with that of ultrasound performed by different examiners to estimate fetal weight. The study investigated whether differences in the examiners' training affected fetal weight estimates. The accuracy of the weight estimates made for fetuses with extreme birth weights was also evaluated. Finally, the accuracy of Johnson's method and of Insler and Bernstein's formula for estimating fetal weight were compared with the other two methods...
March 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28391748/small-for-gestational-age-babies-of-low-risk-term-pregnancies-does-antenatal-detection-matter
#17
Catarina Policiano, Andreia Fonseca, Jorge M Mendes, Nuno Clode, Luís M Graça
OBJECTIVES: To compare delivery route and admission rate to neonatal intensive care unit between small- and appropriate-for-gestational-age babies among low-risk term pregnancies. METHODS: A retrospective study was conducted using the database of deliveries in 2014 at a tertiary hospital. Babies delivered at ≥37 weeks with birthweight <10th centile were considered small-for-gestational-age (SGA) and >90th centile were considered large-for-gestational-age...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28369636/maternal-fenvalerate-exposure-induces-fetal-intrauterine-growth-restriction-through-disrupting-placental-thyroid-hormone-receptor-signaling
#18
Bo Wang, Ji-Jie Liu, Yan Wang, Lin Fu, Ru Shen, Zhen Yu, Hua Wang, Yuan-Hua Chen, Cheng Zhang, Xiu-Hong Meng, De-Xiang Xu
Fenvalerate is an environmental endocrine disruptor that disrupts testosterone and estradiol synthesis. Nevertheless, whether fenvalerate disturbs placental TR signaling remains unclear. The aim of this study was to investigate whether maternal fenvalerate exposure causes fetal intrauterine growth restriction (IUGR) and to explore the role of placental thyroid hormone receptor (TR) signaling. Pregnant mice except controls were orally administered to fenvalerate (0.2, 2.0 or 20 mg/kg) daily throughout pregnancy...
March 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28368218/fine-particulate-matter-pm2-5-a-risk-factor-for-rat-gestational-diabetes-with-altered-blood-glucose-and-pancreatic-glut2-expression
#19
Liu Yi, Chen Wei, Wang Fan
Recent studies have shown an intriguing association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter2 (GLUT2) expression in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose during pregnancy. After exposure, interleukin-6 (IL-6) and blood routine tests (BRT) were detected. Pancreas underwent pathologic examination. The levels of pancreatic homogenate glutathione peroxidase (GSH-Px), methane dicarboxylic aldehyde (MDA) and GLUT2 were detected...
April 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28355605/the-use-of-a-software-assisted-method-to-estimate-fetal-weight-at-and-near-term-using-magnetic-resonance-imaging
#20
Caroline Kadji, Maxime De Groof, Margaux F Camus, Riccardo De Angelis, Stéphanie Fellas, Magdalena Klass, Vera Cecotti, Vivien Dütemeyer, Elie Barakat, Mieke M Cannie, Jacques C Jani
OBJECTIVE: The aim of this study was to apply a semi-automated calculation method of fetal body volume and, thus, of magnetic resonance-estimated fetal weight (MR-EFW) prior to planned delivery and to evaluate whether the technique of measurement could be simplified while remaining accurate. METHODS: MR-EFW was calculated using a semi-automated method at 38.6 weeks of gestation in 36 patients and compared to the picture archiving and communication system (PACS)...
March 30, 2017: Fetal Diagnosis and Therapy
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