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https://www.readbyqxmd.com/read/29672865/dietary-iron-fortification-normalizes-fetal-hematology-hepcidin-and-iron-distribution-in-a-rat-model-of-prenatal-alcohol-exposure
#1
Shane M Huebner, Kaylee K Helfrich, Nipun Saini, Sharon E Blohowiak, Adrienne A Cheng, Pamela J Kling, Susan M Smith
BACKGROUND: Prenatal alcohol exposure (PAE) causes neurodevelopmental disability. Clinical and animal studies show gestational iron deficiency exacerbates PAE's behavioral and growth deficits. In rat, PAE manifests an inability to establish iron homeostasis, increasing hepcidin (maternal and fetal) and fetal liver iron while decreasing brain iron and promoting anemia. Here, we hypothesize dietary iron fortification during pregnancy may mitigate alcohol's disruption of fetal iron homeostasis...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29660172/predictive-accuracy-of-the-southwest-thames-obstetric-research-collaborative-stork-chorionicity-specific-twin-growth-charts-for-stillbirth-a-validation-study
#2
Erkan Kalafat, Mercedes Sebghati, Basky Thilaganathan, Asma Khalil
OBJECTIVE: Twin pregnancy is associated with 2-3 fold increased risk of stillbirth compared to singletons. Despite the fact that the growth pattern has been shown to differ in twins compared to singletons, it is controversial whether twin-specific growth charts should be routinely used. A major goal of prenatal ultrasound is to identify fetuses suffering from growth restriction at risk of stillbirth. The main aim of this study was to compare the performance of chorionicity-specific twin charts with singleton charts, both customized and non-customized, in the antenatal prediction of small-for-gestational age (SGA) stillborn and liveborn fetuses...
April 16, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29630011/a-comparison-of-methods-for-the-diagnosis-of-fetal-growth-restriction-between-the-royal-college-of-obstetricians-and-gynaecologists-and-the-american-college-of-obstetricians-and-gynecologists
#3
Nathan R Blue, Meghan E Beddow, Mariam Savabi, Vivek R Katukuri, Ellen L Mozurkewich, Conrad R Chao
OBJECTIVE: The Royal College of Obstetricians and Gynaecologists (RCOG) defines fetal growth restriction as ultrasound-estimated fetal weight less than the 10th percentile or abdominal circumference less than the 10th percentile; the American College of Obstetricians and Gynecologists (ACOG) defines fetal growth restriction as estimated fetal weight less than the 10th percentile alone. We compared each method's ability to predict small for gestational age (SGA) at birth. METHODS: For this retrospective study of diagnostic accuracy, we reviewed deliveries at the University of New Mexico Hospital from January 1, 2013, to March 31, 2017...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29626438/aquaporin-1-gene-deletion-affects-the-amniotic-fluid-volume-and-composition-as-well-as-the-expression-of-other-aquaporin-water-channels-in-placenta-and-fetal-membranes
#4
Hui Luo, Ailan Xie, Ying Hua, Jing Wang, Yanyun Liu, Xueqiong Zhu
OBJECTIVE: To explore the role of aquaporin 1 (AQP1) in regulation of amniotic fluid volume and composition. To investigate the effects of AQP1 gene knockout on expression of other aquaporin water channels (AQP3, AQP8 and AQP9) in placentas and fetal membranes. METHODS: Mice were sacrificed at 9.5, 13.5 and 16.5 gestational day (GD). Amniotic fluid volume, osmolality and composition, fetal membranes, placental and fetal weights as well as placenta areas were recorded in AQP1 homozygote conceptus group, heterozygote conceptus group and wild-type group, respectively...
April 4, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29614276/induction-of-labor-using-one-dose-versus-multiple-doses-of-misoprostol-a-randomized-controlled-trial
#5
Verónica Maria Pimentel, Moona Arabkhazaeli, Jee-Young Moon, Alexander Wang, Arisa Kapedani, Peter S Bernstein, Pamela J Tropper
BACKGROUND: Misoprostol is a common agent used to ripen the cervix and induce labor, yet there is no clear evidence of the optimal number of doses needed to achieve a higher rate of vaginal delivery. OBJECTIVE: Our primary objective was to compare the rate of vaginal delivery within 24 hours between a one-dose and a multiple-dose regimen of misoprostol for induction of labor STUDY DESIGN: A randomized controlled trial was conducted from March 2016 to March 2017 comparing a single dose to up to four doses of misoprostol...
March 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29611251/ultrasonographic-estimation-of-fetal-weight-development-of-new-model-and-assessment-of-performance-of-previous-models
#6
Aymen Hammami, Alicia Mazer Zumaeta, Argyro Syngelaki, Ranjit Akolekar, Kypros H Nicolaides
OBJECTIVE: To develop a new formula for ultrasonographic estimation of fetal weight (EFW) and evaluate the accuracy of this and all previous formulas in the prediction of birthweight. METHODS: The study population consisted of 5,163 singleton pregnancies with fetal biometry at 22-43 weeks' gestation and livebirth of phenotypically normal neonates within 2 days of the ultrasound examination. Multivariable fractional polynomial analysis was used to determine the combination of variables that provided the best-fitting models for EFW...
April 2, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29609483/a-method-for-estimating-fetal-weight-based-on-body-composition
#7
Chen Bo, Yu Jie, Gao Xiu-E, Fan Gui-Chuan, Zhang Wen-Long
Fetal weight is an important factor to determine the delivery mode of pregnant women. The change of fetal weight is significant, according to regular health monitoring of pregnant women. Conventional methods of fetal weight estimation, namely those based on B-ultrasound, are very complicated and the costs are high. In this paper, we propose a new method based on body composition. An abdominal four-segment impedance model is first established upon pregnant women, as well as the method of calculation. A body composition based method is then given to estimate the fetal weight, with the solution given explicitly...
April 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29607579/ultrasonographic-prediction-of-antepartum-deterioration-of-growth-restricted-fetuses-after-late-preterm
#8
Ryo Yamamoto, Keisuke Ishii, Erika Nakajima, Jun Sasahara, Nobuaki Mitsuda
AIM: To examine the predictive value of ultrasound parameters for antepartum non-reassuring fetal status (NRFS) in fetal growth restriction (FGR) cases after late preterm. METHODS: Retrospective review of singleton FGR cases before 37 weeks gestation who delivered after 34 weeks gestation was performed. The association between ultrasound parameters that was assessed from 34 to 36 weeks gestation and the development of antepartum NRFS that was diagnosed by nonstress test and biophysical profile was analyzed by using multivariate Cox proportional hazards analyses...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29607557/maternal-hemodynamics-fetal-biometry-and-dopplers-in-pregnancies-followed-up-for-suspected-fetal-growth-restriction
#9
Llinos A Roberts, Hua Zen Ling, Liona Poon, Kypros H Nicolaides, Nikos A Kametas
OBJECTIVES: To assess whether in a cohort of patients with small for gestational age (SGA) foetuses with estimated fetal weight ≤10th percentile, maternal hemodynamics, fetal biometry and Dopplers at presentation, can predict the subsequent development of abnormal fetal Dopplers or delivery with birthweight <3rd percentile. METHODS: The study population comprised of 86 singleton pregnancies with SGA fetuses presenting at a median gestational age of 32 (range 26-35) weeks...
April 1, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29606482/planning-management-and-delivery-of-the-growth-restricted-fetus
#10
REVIEW
Ahmet A Baschat
A uniform approach to management of fetal growth restriction (FGR) improves outcome, prevents stillbirth, and allows appropriately timed delivery. An estimated fetal weight below the tenth percentile with coexisting abnormal umbilical artery (UA), middle cerebral artery (MCA), or cerebroplacental ratio Doppler index best identifies the small fetus requiring surveillance. Placental perfusion defects are more common earlier in gestation; accordingly, early-onset (≤32 weeks of gestation) and late-onset (>32 weeks) FGR differ in clinical phenotype...
March 1, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29606022/associations-between-neural-injury-markers-of-intrauterine-growth-restricted-infants-and-neurodevelopment-at-2-years-of-age
#11
E Mazarico, E Llurba, L Cabero, O Sánchez, A Valls, A Martin-Ancel, D Cardenas, M D Gómez Roig
OBJECTIVES: The aim of this study was to evaluate the relationships between brain injury biomarkers in intrauterine growth-restricted (IUGR) infants (S100B and neuron-specific enolase (NSE)) and neurodevelopment at 2 years of age. METHODS: This prospective case-control study was a cooperative effort among Spanish Maternal and Child Health Network (Retic SAMID) hospitals. At inclusion, biometry for estimated fetal weight and feto-placental Doppler variables were measured for each infant...
March 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29605157/fetal-biometry-to-assess-the-size-and-growth-of-the-fetus
#12
REVIEW
Neil O'Gorman, Laurent J Salomon
Ultrasound assessment of fetal size is central to modern practice of prenatal care. It facilitates accurate pregnancy dating and screening for fetal growth disorders. This article discusses evidence-based recommended methods for pregnancy dating and biometric measurements. We address some confusing terms such as fetal growth "standards" and fetal growth "references" along with explaining the differences between prescriptive and descriptive charts and between growth charts based on estimated fetal weight vs those based on birth weight...
February 23, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29580120/placental-growth-factor-as-a-predictor-of-the-efficacy-of-tadalafil-treatment-for-fetal-growth-restriction
#13
Michiko Kubo-Kaneda, Hiroaki Tanaka, Shintaro Maki, Masafumi Nii, Takashi Umekawa, Kazuhiro Osato, Yuki Kamimoto, Eiji Kondo, Tomoaki Ikeda
PURPOSE: We recently demonstrated the efficacy of tadalafil treatment for fetal growth restriction (FGR). This study aimed to evaluate the utility of serum placental growth factor (PlGF) level for predicting the efficacy of tadalafil for the treatment of FGR. MATERIALS AND METHODS: The correlations between serum level of PlGF and fetal growth velocity were retrospectively assessed in nine pregnant women receiving tadalafil for FGR before 30 weeks' gestation. RESULTS: Median gestational age was 26 weeks (range 26-28 weeks), and median deviation of estimated fetal weight from standard weight was -2...
March 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29573501/first-trimester-and-combined-first-and-second-trimester-prediction-of-small-for-gestational-age-and-fetuses-with-late-growth-restriction
#14
Alexandros Sotiriadis, Francesc Figueras, Makarios Eleftheriades, George K Papaioannou, Georgios Chorozoglou, Konstantinos Dinas, Nikolaos Papantoniou
AIM: To develop a first-trimester or combined first- and second-trimester screening algorithm for the prediction of small-for-gestational age (SGA) and late growth-restriction (FGR). METHODS: This was a retrospective study of pregnant women with singleton pregnancy, who attended routine first- second- and third-trimester ultrasound scan. Late FGR was defined, at ≥32 weeks in the absence of congenital anomalies as, either (a) estimated fetal weight (EFW) or birthweight (BW) <3rd centile , OR (b) EFW<10th centile and either uterine artery mean PI >95th centile or cerebroplacental ratio (CPR) <5th centile...
March 24, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29568742/therapeutic-effect-of-long-term-epidural-block-in-rats-with-pregnancy-induced-hypertension
#15
Nianjiao Han, Yang Li, Youjing Dong
Background: Pregnancy induced hypertension (PIH) causes a variety of systemic disorders that negatively affect the maternal placenta and fetal growth. Epidural sympathetic block elicits symptoms of decreased blood pressure. This study was designed to determine the therapeutic effect of long-term epidural block in rats with PIH. Methods: Forty healthy pregnant Sprague Dawley rats were randomized into four groups with each group consisting of 10 rats. On gestation day (GD) 14, rats in control group underwent a sham procedure; rats in RUPP group were operated on to obtain reduced uterine perfusion pressure (RUPP); rats in RUPP plus normal saline (NS) group were also subjected to the RUPP procedure and underwent epidural block with 25  μ l normal saline twice daily until delivery; rats in RUPP plus epidural block (EB) group were treated as those in RUPP plus NS group except that an epidural block with 25  μ l of 0...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29550943/reliability-of-sonographic-fetal-weight-estimation-in-triplet-pregnancies-a-retrospective-cohort-study
#16
Sophie Pils, Stephanie Springer, Rudolf Seemann, Verena Wehrmann, Christof Worda, Johannes Ott
PURPOSE: To review our experience in ultrasound fetal weight estimation in our large population of triplet pregnancies. METHODS: Ninety-seven triplet pregnancies were retrospectively included between January 2003 and January 2017. Sonographic fetal weight estimation using Hadlock's and Schild's formulas was compared to actual birth weight in a tertiary-care center in Vienna, Austria. Statistical analyses were performed using a stepwise linear regression model and crosstabs...
March 17, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29533539/cord-blood-lipid-profile-in-healthy-newborns-a-prospective-single-center-study
#17
Elżbieta Pac-Kożuchowska, Anna Rakuś-Kwiatosz, Paulina Krawiec
BACKGROUND: Atherosclerosis may originate during the fetal period, therefore it is reasonable to identify early risk markers of lifestyle diseases. OBJECTIVES: The aim of the study was to determine the relationship between fetal and maternal factors, and the neonatal cord blood lipid profile in term newborns. MATERIAL AND METHODS: In the study group, there were 206 healthy Polish newborns. Newborn characteristics included sex, gestational age at birth, Apgar score, and anthropometric data (weight and length at birth, neonatal ponderal index, head, chest and abdominal circumferences, placenta weight, and placental-fetal weight ratio)...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29522541/comparison-of-diurnal-variations-gestational-age-and-gender-related-differences-in-fetal-heart-rate-fhr-parameters-between-appropriate-for-gestational-age-aga-and-small-for-gestational-age-sga-fetuses-in-the-home-environment
#18
Habiba Kapaya, Richard Jacques, Dilly Anumba
OBJECTIVE: To assess the influence of gender, time of the day and gestational age on fetal heart rate (FHR) parameters between appropriate-for-gestational-age (AGA) and small-for-gestational age (SGA) fetuses using a portable fetal ECG monitor employed in the home setting. METHODS: We analysed and compared the antenatal FHR data collected in the home setting on 61 healthy pregnant women with singleton pregnancies from 24 weeks gestation. Of the 61 women, 31 had SGA fetuses (estimated fetal weight below the tenth gestational centile) and 30 were pregnant with AGA fetuses...
2018: PloS One
https://www.readbyqxmd.com/read/29495013/high-tumor-volume-to-fetal-weight-ratio-is-associated-with-worse-fetal-outcomes-and-increased-maternal-risk-in-fetuses-with-sacrococcygeal-teratoma
#19
Juliana S Gebb, Nahla Khalek, Huma Qamar, Mark P Johnson, Edward R Oliver, Beverly G Coleman, William H Peranteau, Holly L Hedrick, Alan W Flake, N Scott Adzick, Julie S Moldenhauer
OBJECTIVE: Tumor volume to fetal weight ratio (TFR) > 0.12 before 24 weeks has been associated with poor outcome in fetuses with sacrococcygeal teratoma (SCT). We evaluated TFR in predicting poor fetal outcome and increased maternal operative risk in our cohort of SCT pregnancies. METHODS: This is a retrospective, single-center review of fetuses seen with SCT from 1997 to 2015. Patients who chose termination of pregnancy (TOP), delivered elsewhere, or had initial evaluation at > 24 weeks were excluded...
March 1, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29485632/effects-of-lipopolysaccharide-and-high-saline-intake-on-blood-pressure-angiogenic-factors-and-liver-enzymes-of-pregnant-rats
#20
G O Oludare, O J Ilo, B A Lamidi
This study investigated the effect of high salt water intake and lipopolysaccharide injection as probable rat models of preeclampsia during pregnancy. Thirty-three female Sprague-Dawley rats weighing between 150-170g were divided into 4 groups of the control (normal saline), high salt water intake (1.8% NaCl from days 13-18 of pregnancy), lipopolysaccharide group (40 µg/kg b.w. ip injection from day 16-18 of pregnancy) and high salt water (1.8% NaCl) and lipopolysaccharide injection (40 µg/kg b.w i.p. from days 16-18 of pregnancy)...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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