keyword
https://read.qxmd.com/read/38536085/the-cryo-em-structure-of-ask1-reveals-an-asymmetric-architecture-allosterically-modulated-by-trx1
#1
JOURNAL ARTICLE
Karolina Honzejkova, Dalibor Kosek, Veronika Obsilova, Tomas Obsil
Apoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways. ASK1 dysregulation has been associated with cancer and inflammatory, cardiovascular, and neurodegenerative diseases, among others. However, our limited knowledge of the underlying structural mechanism of ASK1 regulation hampers our ability to target this member of the MAP3K protein family towards developing therapeutic interventions for these disorders...
March 27, 2024: ELife
https://read.qxmd.com/read/38535971/research-progress-on-the-association-between-microrna-and-postoperative-cognitive-dysfunction
#2
JOURNAL ARTICLE
Yuanping Zhong, Yu Zhang, Zhaoqiong Zhu
Postoperative cognitive dysfunction (POCD) is a significant complication following surgery. The precise mechanisms underlying POCD remain elusive, although it is speculated that they involve central nervous system inflammation, oxidative stress and cellular apoptosis. MicroRNAs (miRNAs), a class of non-coding RNAs widely distributed in eukaryotes, have been implicated in the pathogenesis of neurodegenerative disorders and could potentially impact POCD. This review explores the association between miRNAs and POCD and provides an overview of the progress of current research on miRNAs in the pathogenesis, diagnosis, and treatment of POCD...
March 2024: Minerva Anestesiologica
https://read.qxmd.com/read/38535505/quantitative-proteomics-reveal-region-specific-alterations-in-neuroserpin-deficient-mouse-brain-and-retina-insights-into-serpini1-function
#3
JOURNAL ARTICLE
Shahab Mirshahvaladi, Nitin Chitranshi, Ardeshir Amirkhani, Rashi Rajput, Devaraj Basavarajappa, Roshana Vander Wall, Dana Pascovici, Angela Godinez, Giovanna Galliciotti, Joao A Paulo, Veer Gupta, Stuart L Graham, Vivek Gupta, Mehdi Mirzaei
Neural regeneration and neuroprotection represent strategies for future management of neurodegenerative disorders such as Alzheimer's disease (AD) or glaucoma. However, the complex molecular mechanisms that are involved in neuroprotection are not clearly understood. A promising candidate that maintains neuroprotective signaling networks is neuroserpin (Serpini1), a serine protease inhibitor expressed in neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury...
March 14, 2024: Proteomes
https://read.qxmd.com/read/38535081/the-contribution-of-functional-near-infrared-spectroscopy-fnirs-to-the-study-of-neurodegenerative-disorders-a-narrative-review
#4
REVIEW
Ioannis Liampas, Freideriki Danga, Panagiota Kyriakoulopoulou, Vasileios Siokas, Polyxeni Stamati, Lambros Messinis, Efthimios Dardiotis, Grigorios Nasios
Functional near-infrared spectroscopy (fNIRS) is an innovative neuroimaging method that offers several advantages over other commonly used modalities. This narrative review investigated the potential contribution of this method to the study of neurodegenerative disorders. Thirty-four studies involving patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), frontotemporal dementia (FTD), Parkinson's disease (PD), or amyotrophic lateral sclerosis (ALS) and healthy controls were reviewed. Overall, it was revealed that the prefrontal cortex of individuals with MCI may engage compensatory mechanisms to support declining brain functions...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38535006/current-trends-and-applications-of-pet-mri-hybrid-imaging-in-neurodegenerative-diseases-and-normal-aging
#5
REVIEW
Jonathan Lee, Jonathan Renslo, Kasen Wong, Thomas G Clifford, Bryce D Beutler, Paul E Kim, Ali Gholamrezanezhad
Dementia is a significant global health issue that is exacerbated by an aging population. Imaging plays an established role in the evaluation of patients with neurocognitive disorders such as dementia. In current clinical practice, magnetic resonance imaging (MRI) and positron emission tomography (PET) are primary imaging modalities used separately but in concert to help diagnose and classify dementia. The clinical applications of PET/MRI hybrid imaging in dementia are an active area of research, particularly given the continued emergence of functional MRI (fMRI) and amyloid PET tracers...
March 10, 2024: Diagnostics
https://read.qxmd.com/read/38534785/cellular-organelle-related-transcriptomic-profile-abnormalities-in-neuronopathic-types-of-mucopolysaccharidosis-a-comparison-with-other-neurodegenerative-diseases
#6
JOURNAL ARTICLE
Karolina Wiśniewska, Lidia Gaffke, Magdalena Żabińska, Grzegorz Węgrzyn, Karolina Pierzynowska
Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) degradation. As a result, GAGs accumulate in lysosomes, impairing the proper functioning of entire cells and tissues. There are 14 types/subtypes of MPS, which are differentiated by the kind(s) of accumulated GAG(s) and the type of a non-functional lysosomal enzyme. Some of these types (severe forms of MPS types I and II, MPS III, and MPS VII) are characterized by extensive central nervous system disorders...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534355/recent-research-trends-in-neuroinflammatory-and-neurodegenerative-disorders
#7
REVIEW
Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins...
March 14, 2024: Cells
https://read.qxmd.com/read/38534313/intravenous-msc-treatment-improves-impaired-brain-functions-in-the-r6-2-mouse-model-of-huntington-s-disease-via-recovered-hepatic-pathological-changes
#8
JOURNAL ARTICLE
Libo Yu-Taeger, Ali El-Ayoubi, Pengfei Qi, Lusine Danielyan, Hoa Huu Phuc Nguyen
Huntington's disease (HD), a congenital neurodegenerative disorder, extends its pathological damages beyond the nervous system. The systematic manifestation of HD has been extensively described in numerous studies, including dysfunction in peripheral organs and peripheral inflammation. Gut dysbiosis and the gut-liver-brain axis have garnered greater emphasis in neurodegenerative research, and increased plasma levels of pro-inflammatory cytokines have been identified in HD patients and various in vivo models, correlating with disease progression...
March 7, 2024: Cells
https://read.qxmd.com/read/38534257/hydrogel-gated-fets-in-neuromorphic-computing-to-mimic-biological-signal-a-review
#9
REVIEW
Sankar Prasad Bag, Suyoung Lee, Jaeyoon Song, Jinsink Kim
Hydrogel-gated synaptic transistors offer unique advantages, including biocompatibility, tunable electrical properties, being biodegradable, and having an ability to mimic biological synaptic plasticity. For processing massive data with ultralow power consumption due to high parallelism and human brain-like processing abilities, synaptic transistors have been widely considered for replacing von Neumann architecture-based traditional computers due to the parting of memory and control units. The crucial components mimic the complex biological signal, synaptic, and sensing systems...
March 19, 2024: Biosensors
https://read.qxmd.com/read/38533783/brain-morphometry-in-former-american-football-players-findings-from-the-diagnose-cte-research-project
#10
JOURNAL ARTICLE
Hector Arciniega, Zachary H Baucom, Fatima Tuz-Zahra, Yorghos Tripodis, Omar John, Holly Carrington, Nicholas Kim, Evdokiya E Knyazhanskaya, Leonard B Jung, Katherine Breedlove, Tim L T Wiegand, Daniel H Daneshvar, R Jarrett Rushmore, Tashrif Billah, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura J Balcer, Michael L Alosco, Inga K Koerte, Alexander P Lin, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Sylvain Bouix
Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI). MRI brain morphometry was evaluated in 170 male former American football players ages 45-74 years (n = 114 professional; n = 56 college) and 54 same-age unexposed asymptomatic male controls (n = 58 age range 45-74)...
March 27, 2024: Brain
https://read.qxmd.com/read/38533577/plasma-neurofilament-light-chain-is-increased-in-niemann-pick-type-c-but-glial-fibrillary-acidic-protein-remains-normal
#11
JOURNAL ARTICLE
Dhamidhu Eratne, Courtney Lewis, Wendy Kelso, Samantha Loi, Wei-Hsuan Michelle Chiu, Kaj Blennow, Henrik Zetterberg, Alexander F Santillo, Dennis Velakoulis, Mark Walterfang
OBJECTIVE: Niemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls. METHODS: Patients with NPC were recruited from a specialist assessment and management service...
March 27, 2024: Acta Neuropsychiatrica
https://read.qxmd.com/read/38533412/editorial-neurological-and-neuropsychiatric-disorders-affecting-military-personnel-and-veterans
#12
EDITORIAL
Chen Lin, Mary Jo Pugh, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Willliam C Walker
No abstract text is available yet for this article.
2024: Frontiers in Neurology
https://read.qxmd.com/read/38533051/therapeutic-potential-of-clinically-proven-natural-products-in-the-management-of-dementia
#13
REVIEW
Farzana Ansari, Md Sohel, Md Mahfujul Haque Haidary, Md Saqline Mostaq, Shamima Akter, Asrafun Nahar, Fatematuz Zohora Labony, Arman Ahmed, Mohammed Shamim Hasan, Mohammad Hasem Babu, Mohammad Nurul Amin
Dementia is a common neurodegenerative disorder connected to damage to nerve cells in the brain. Although some conventional drugs are available for dementia treatments and are still sanctified for dementia patients, their short- and long-term side effects and other limitations make treating patients more challenging. The authors aimed to explain novel options for treating dementia with natural products and unravel some clinically proven natural products. This article systematically reviewed recent studies that have investigated the role of natural products and their bioactive compounds for dementia...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532803/sex-differences-in-multiple-sclerosis-relapse-presentation-and-outcome-a-retrospective-monocentric-study-of-134-relapse-events
#14
JOURNAL ARTICLE
Pauline Thränhardt, Admirim Veselaj, Christoph Friedli, Franca Wagner, Stefanie Marti, Lara Diem, Helly Hammer, Piotr Radojewski, Roland Wiest, Andrew Chan, Robert Hoepner, Anke Salmen
BACKGROUND: Reporting of sex-specific analyses in multiple sclerosis (MS) is sparse. Disability accrual results from relapses (relapse-associated worsening) and independent thereof (progression independent of relapses). OBJECTIVES: A population of MS patients during relapse treated per standard of care was analyzed for sex differences and short-term relapse outcome (3-6 months) as measured by Expanded Disability Status Scale (EDSS) change. DESIGN: Single-center retrospective study...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38532802/patisiran-exposure-in-early-pregnancy-a-case-report
#15
Valentin Loser, Thomas Baumgartner, Hélène Legardeur, Alice Panchaud, Marie Théaudin
We describe here the first case of exposure to patisiran treatment, a small interfering RNA molecule, during early pregnancy of a 36-year-old woman with symptomatic hereditary transthyretin-related amyloidosis. There were no major complications during pregnancy and delivery, except for a postpartum hemorrhage due to uterine atony. Vitamin A levels had to be closely monitored during pregnancy, and vitamin A substitution adapted accordingly. There was no sign of minor or major congenital abnormalities of the baby...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38532801/improved-visualization-of-median-ulnar-nerves-and-small-branches-in-the-wrist-and-palm-using-contrast-enhanced-magnetic-resonance-neurography
#16
JOURNAL ARTICLE
Jiamin Kang, Wenjun Wu, Xiangchuang Kong, Yu Su, Dingxi Liu, Chungao Li, Nan Gao, Youzhi Wang, Chuansheng Zheng, Yuxiong Weng, Lixia Wang
BACKGROUND: Magnetic resonance imaging of peripheral nerves in the wrist and palm is challenging due to the small size, tortuous course, complex surrounding tissues, and accompanying blood vessels. The occurrence of carpal palmar lesions leads to edema, swelling, and mass effect, which may further interfere with the display and identification of nerves. OBJECTIVE: To evaluate whether contrast-enhanced magnetic resonance neurography (ceMRN) improves the visualization of the morphology and pathology of the median, ulnar nerves, and their small branches in the wrist and palm...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38532785/nebulization-of-low-dose-aspirin-ameliorates-huntington-s-pathology-in-n171-82q-transgenic-mice
#17
JOURNAL ARTICLE
Susanta Mondal, Shelby Prieto, Suresh B Rangasamy, Debashis Dutta, Kalipada Pahan
Huntington Disease (HD), a devastating hereditary neurodegenerative disorder, is caused by expanded CAG trinucleotide repeats in the huntingtin gene ( Htt ) on chromosome 4. Currently, there is no effective therapy for HD. Although aspirin, acetylsalicylic acid, is one of the most widely-used analgesics throughout the world, it has some side effects. Even at low doses, oral aspirin can cause gastrointestinal symptoms, such as heartburn, upset stomach, or pain. Therefore, to bypass the direct exposure of aspirin to stomach, here, we described a new mode of use of aspirin and demonstrated that nebulization of low-dose of aspirin (10 μg/mouse/d=0...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532240/uncovering-cell-cycle-dysregulations-and-associated-mechanisms-in-cancer-and-neurodegenerative-disorders-a-glimpse-of-hope-for-repurposed-drugs
#18
REVIEW
Dia Advani, Pravir Kumar
The cell cycle is the sequence of events orchestrated by a complex network of cell cycle proteins. Unlike normal cells, mature neurons subsist in a quiescent state of the cell cycle, and aberrant cell cycle activation triggers neuronal death accompanied by neurodegeneration. The periodicity of cell cycle events is choreographed by various mechanisms, including DNA damage repair, oxidative stress, neurotrophin activity, and ubiquitin-mediated degradation. Given the relevance of cell cycle processes in cancer and neurodegeneration, this review delineates the overlapping cell cycle events, signaling pathways, and mechanisms associated with cell cycle aberrations in cancer and the major neurodegenerative disorders...
March 26, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38532069/sitagliptin-elevates-plasma-and-csf-incretin-levels-following-oral-administration-to-nonhuman-primates-relevance-for-neurodegenerative-disorders
#19
JOURNAL ARTICLE
Yazhou Li, Kelli L Vaughan, Yun Wang, Seong-Jin Yu, Eun-Kyung Bae, Ian A Tamargo, Katherine O Kopp, David Tweedie, Cheng-Chuan Chiang, Keith T Schmidt, Debomoy K Lahiri, Michael A Tones, Margaret M Zaleska, Barry J Hoffer, Julie A Mattison, Nigel H Greig
The endogenous incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) possess neurotrophic, neuroprotective, and anti-neuroinflammatory actions. The dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin reduces degradation of endogenous GLP-1 and GIP, and, thereby, extends the circulation of these protective peptides. The current nonhuman primate (NHP) study evaluates whether human translational sitagliptin doses can elevate systemic and central nervous system (CNS) levels of GLP-1/GIP in naive, non-lesioned NHPs, in line with our prior rodent studies that demonstrated sitagliptin efficacy in preclinical models of Parkinson's disease (PD)...
March 27, 2024: GeroScience
https://read.qxmd.com/read/38531956/darier-disease-is-associated-with-neurodegenerative-disorders-and-epilepsy
#20
JOURNAL ARTICLE
Philip Curman, William Jebril, Henrik Larsson, Etty Bachar-Wikstrom, Martin Cederlöf, Jakob D Wikstrom
Darier disease (DD) is a rare monogenetic skin disorder with limited data on its potential association with neurological disorders. This study aimed to investigate the association between DD and neurological disorders, specifically Parkinson's disease, dementias, and epilepsy. Using Swedish national registers in a period spanning between 1977 and 2013, 935 individuals with DD were compared with up to 100 comparison individuals each, randomly selected from the general population based on birth year, sex, and county of residence at the time of the first diagnosis of DD...
March 26, 2024: Scientific Reports
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