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Giant cell tumor of bone

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https://www.readbyqxmd.com/read/29350012/-application-of-debridement-and-bone-autografting-combined-with-proximal-femoral-anatomical-plates-for-benign-tumor-in-proximal-femur
#1
Ye Tian, Long-Gang Chen, Bin Shi, Nan Zhang, Qin Fu
OBJECTIVE: To explore the clinical effects of debridement and bone autografting combined with proximal femoral anatomical plate in treating benign tumor in proximal femur. METHODS: From January 2010 to October 2014, 30 patients with benign tumor in proximal femur were treated with debridement, autogenic ilium, autogenic ilium and allogeneic bone implant, and anatomic plate fixation. Among them, there were 13 males and 17 females aged from 12 to 68 years old with an average of 42 years old...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29334779/extra-articular-tenosynovial-giant-cell-tumor-of-diffuse-type-in-the-temporal-area-with-brain-parenchymal-invasion-a-case-report
#2
Seung-Myoung Son, Young Seok Park, Chi-Hoon Choi, Ho-Chang Lee, Ok-Jun Lee, Chang Gok Woo
Tenosynovial giant cell tumor of diffuse type is a locally aggressive neoplasm that most commonly arises in the lower extremities. Herein, we report for the first time a case of an extra-articular tenosynovial giant cell tumor of diffuse type in the temporal region with brain parenchymal invasion. Imaging studies revealed an intracranial expansile mass in the temporal bone without involvement of the temporomandibular joint. The unusual location of the tumor without involvement of the joint and the presence of brain parenchymal invasion made this case challenging to diagnose...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29315595/mid-to-long-term-clinical-outcome-of-giant-cell-tumor-of-bone-treated-with-calcium-phosphate-cement-following-thorough-curettage-and-phenolization
#3
Akihiko Takeuchi, Prakrit Suwanpramote, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Hiroyuki Tsuchiya
BACKGROUND AND OBJECTIVES: Giant cell tumors of bone (GCTB) are intermediate and locally aggressive bone tumor. Calcium phosphate cement (CPC) is a bone void filler used in orthopaedic surgery. This study investigated the clinical outcome of GCTB treated with thorough curettage, phenolization, and CPC. METHODS: We investigated 26 patients with at least 36 months of follow-up. The mean age and follow-up were 37 years (range: 19-63) and 87 months (range: 38-169), respectively...
January 8, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29303762/giant-schwannoma-of-the-hard-palate-a-literature-review-and-report-of-an-uncommon-case
#4
Cristinne Andrade Melo, Paulo Almeida-Júnior, Allan Ulisses de Carvalho Melo, Cyntia Ferreira Ribeiro, Cláudio Élcio Siqueira de Lira, Juliana Batista Melo da Fonte, Maria Fátima Batista de Melo, Wilton Mitsunari Takeshita, Ricardo Luiz Cavalcanti de Albuquerque-Júnior
Schwannomas (also known as neurilemomas) are benign tumors that arise from the Schwann cells of the nerve sheath. While they seldom occur in the oral cavity, the tongue is the most common site. Palatal schwannomas are extremely rare. This article reports a case of a large, slowly developing schwannoma that caused bone erosion in the hard palate of an 18-year-old man. The diagnosis was based on histopathologic and immunohistochemical findings. The tumor was completely excised, and no recurrence was observed at a 1-year follow-up...
January 2018: General Dentistry
https://www.readbyqxmd.com/read/29296223/development-and-validation-of-a-prognostic-index-to-predict-pulmonary-metastasis-of-giant-cell-tumor-of-bone
#5
Bo Wang, Wei Chen, Xianbiao Xie, Jian Tu, Gang Huang, Changye Zou, Junqiang Yin, Lili Wen, Jingnan Shen
Purpose: Giant cell tumor of bone (GCTB) is an intermittent tumor with a low probability of pulmonary metastasis. Our aim was to investigate the risk factors and establish a nomogram predictive model for GCTB pulmonary metastasis. Methods: We retrospectively evaluated GCTB patients at our center from 1991 to 2014. The cohort was randomized into training and validation sets. Univariate and multivariate analyses were used to evaluate the risk factors of pulmonary metastasis...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29279827/parotid-mandibular-bone-defect-a-case-report-emphasizing-imaging-features-in-plain-radiographs-and-magnetic-resonance-imaging
#6
Miki Hisatomi, Luciana Munhoz, Junichi Asaumi, Emiko Saito Arita
Mandibular bone depression, also known as Stafne bone cavity, is defined as a bone depression filled mainly with salivary gland tissue. Parotid gland bone defects are infrequently observed. We report the case of a 52-year-old male patient who underwent radiographic examinations due to temporomandibular joint dysfunction, and a radiolucent area was detected in the mandibular ramus, with a provisional diagnosis of traumatic bone cyst or parotid mandibular bone defect. The patient was then referred for magnetic resonance imaging, which demonstrated a hyperintense area eroding the mandibular ramus, which corresponded to glandular tissue...
December 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29273889/tumor-necrosis-factor-receptor-associated-factor-6-is-required-to-inhibit-foreign-body-giant-cell-formation-and-activate-osteoclasts-under-inflammatory-and-infectious-conditions
#7
Akihito Oya, Eri Katsuyama, Mayu Morita, Yuiko Sato, Tami Kobayashi, Kana Miyamoto, Toru Nishiwaki, Atsushi Funayama, Yoshinari Fujita, Takashi Kobayashi, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Osteoclasts and foreign body giant cells (FBGCs) are derived from common progenitors and share properties such as multi-nucleation capacity induced by cell-cell fusion; however, mechanisms underlying lineage determination between these cells remain unclear. Here we show that, under inflammatory conditions, osteoclasts are stimulated in a manner similar to M1 macrophages, while formation of FBGCs, which exhibit M2-like phenotypes, is inhibited in a manner similar to that seen in M1/M2 macrophage polarization...
December 22, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29244665/osseous-myopericytoma-simulating-a-giant-cell-tumor-of-bone-a-case-report
#8
Eric Bellinger, Ivy John, Daniel Zaccarini, Timothy A Damron
CASE: Myopericytoma is a benign perivascular myoid neoplasm that typically presents in the dermal and subcutaneous soft tissues of the distal aspect of the extremities. These types of tumor form a clinicopathological spectrum with myofibromas, angiopericytomas, angioleiomyomas, and glomus tumors. Intraosseous myopericytomas are exceptionally rare, and to our knowledge, no cases of myopericytoma involving long bones previously have been described. We present a case of myopericytoma occurring in the distal aspect of the femur of a 36-year-old man...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29241742/diagnostic-utility-of-histone-h3-3g34-w-g34r-and-g34-v-mutant-specific-antibodies-for-giant-cell-tumors-of-bone
#9
Hidetaka Yamamoto, Takeshi Iwasaki, Yuichi Yamada, Yoshihiro Matsumoto, Hiroshi Otsuka, Masato Yoshimoto, Kenichi Kohashi, Kenichi Taguchi, Ryohei Yokoyama, Yasuharu Nakashima, Yoshinao Oda
Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% have H3F3A gene mutation. The RANKL inhibitor denosumab, when used for the treatment of GCTB, leads to histological changes such as new bone formation and giant cell depletion. Here we assessed the diagnostic utility of immunohistochemical staining with the antibodies against histone H3.3G34 W, G34R and G34 V mutant proteins for GCTB and other histologically similar bone and joint lesions...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29239274/magnetic-resonance-feature-of-paintbrush-borders-sign-as-a-novel-way-to-predict-recurrence-of-giant-cell-tumor-of-bone-after-curettage-a-pilot-study
#10
Yifeng He, Jun Wang, Ji Zhang, Lianjun Du, Yong Lu, Jianqiang Xu, Fei Yuan, Yimin Tan, Xiaoyi Ding
Objective To identify the prognostic factors for local recurrence of giant cell tumor of bone (GCTB) through assessment of the preoperative imaging features of the tumor border. Methods Patients with GCTBs treated with intralesional procedures in the proximal tibia and distal femur were prospectively enrolled and then followed up for at least 2 years. The GCTBs were grouped according to their preoperative imaging features. GCTBs treated with en bloc resection were enrolled for investigation of the pathologic basis of specific imaging features...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29220303/locally-aggressive-connective-tissue-tumors
#11
Mrinal M Gounder, David M Thomas, William D Tap
In this review, we highlight the complexities of the natural history, biology, and clinical management of three intermediate connective tissue tumors: desmoid tumor (DT) or aggressive fibromatosis, tenosynovial giant cell tumor (TGCT) or diffuse-type pigmented villonodular synovitis (dtPVNS), and giant cell tumor of bone (GCTB). Intermediate histologies include tumors of both soft tissue and bone origin and are locally aggressive and rarely metastatic. Some common aspects to these tumors are that they can be locally infiltrative and/or impinge on critical organs, which leads to disfigurement, pain, loss of function and mobility, neurovascular compromise, and occasionally life-threatening consequences, such as mesenteric, bowel, ureteral, and/or bladder obstruction...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29217425/usp6-gene-rearrangement-differentiate-primary-paranasal-sinus-solid-aneurysmal-bone-cyst-from-other-giant-cell-rich-lesions-report-of-a-rare-case
#12
Hung-Ru Li, Chih-Feng Tai, Hsuan-Ying Huang, Ying-Tai Jin, Yi-Ting Chen, Sheau-Feng Yang
Aneurysmal bone cysts (ABCs) mostly occur in the metaphysis of long bones. Primary paranasal ABCs are extremely rare and most reported cases reveal typical histopathological features including cystic space with fibrous septa and hemorrhage. Solid variant ABCs or solid ABCs lacking cyst formation may be histologically indistinguishable from giant cell reparative granulomas (GCRGs), giant cell tumor of bone (GCTB), and brown tumor. Here we report the case of a 24-year-old female with a paranasal mass diagnosed as USP6-rearranged solid ABC, mimicking GCRG, GCTB and brown tumor...
December 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/29215692/chondroid-tenosynovial-giant-cell-tumor-of-the-temporomandibular-joint-a-rare-case-report
#13
Ana Lia Anbinder, Barbara Maria Corrêa Geraldo, Rubens Guimarães, Débora Lima Pereira, Oslei Paes de Almeida, Yasmin Rodarte Carvalho
Tenosynovial giant cell tumor of diffuse type (TGCT-d) or pigmented villonodular synovitis (PVNS) is a locally aggressive lesion that mostly affects the joints of long bones. Chondroid tenosynovial giant cell tumor (CTGCT) or PVNS with chondroid metaplasia is a rare distinct subset of synovial tumors that has a predilection for the TMJ. We report a rare case of CTGCT in the TMJ, initially misdiagnosed as temporomandibular disorder (TMD). A 51-year-old woman was referred to the surgeon with the chief complaint of TMJ pain for 5 years and a past history of an unsuccessful TMD treatment...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29193813/a-case-report-of-brown-tumor-in-a-patient-with-chronic-renal-failure-and-renal-cell-carcinoma
#14
Yong-Jun Liu, Elizabeth E Frauenhoffer, Eric Walker, Nicole C Williams
We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. A concurrent core biopsy showed foci of spindled cell proliferation populated by osteoclast-like giant cells with stromal hemorrhage without evidence of metastatic carcinoma...
November 29, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29182026/extensor-carpi-ulnaris-tenodesis-versus-no-stabilization-after-wide-resection-of-distal-ulna-giant-cell-tumors
#15
Ioannis D Papanastassiou, Olga D Savvidou, George D Chloros, Panayiotis D Megaloikonomos, Vasileios A Kontogeorgakos, Panayiotis J Papagelopoulos
BACKGROUND: The necessity of stabilizing the residual ulnar stump after distal ulna tumor resection remains controversial. The authors retrospectively compared the outcome of patients who underwent wide resection of distal ulna giant cell tumors (GCTs) and reconstruction with tenodesis of the extensor carpi ulnaris (ECU) or without reconstruction. METHODS: Between 2007 and 2015, 9 patients (6 females, 3 males; mean age, 36.8 years; range, 24-65 years) who underwent distal ulna resection for GCT of bone were retrospectively reviewed...
November 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29181359/articular-reconstruction-using-subchondral-cementation-and-threaded-kirschner-wires-in-giant-cell-tumor-a-novel-technique
#16
Padmanabh H Vora, Rameez Musa, Neel M Bhavsar, Darshan Shah
Introduction: Giant Cell Tumor(GCT) is one of an infrequently encountered tumor by orthopaedic surgeons in clinical practice. It is described as 'locally malignant' tumor found in epimetaphyseal region of long bones, peculiarly around knee. We present a case of a solitary, benign Campanacci Grade 2 GCT in right lateral femoral condyle in 38 year old female and our treatment. Case Report: A 38 year old female presented to our outpatient department with chief complaint of constant, moderate pain in right knee increasing in duration since 3 months...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29164581/microrna-30c-suppressed-giant-cell-tumor-of-bone-cell-metastasis-and-growth-via-targeting-hoxa1
#17
L-Y Ni, J-D Zhao, Y-H Lu, W Li, B-L Li, X-C Wang, Q-G Meng
OBJECTIVE: To dissect the functioning mode of miR-30c on giant cell tumor of bone cell metastasis and growth and provide therapeutic targets for giant cell tumor of bone. PATIENTS AND METHODS: By quantitative Real-time polymerase chain reaction (qRT-PCR), miR-30c expression level in 62 pairs of giant cell tumor of bone cells tissue samples and five breast cancer-derived cell lines. Using miR-30c mimics and inhibitors, we analyzed the effects of miR-30c over-expression and knockdown on cell proliferation, invasion, and migration...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164473/clinicopathological-and-immunohistochemical-study-of-head-and-neck-langerhans-cell-histiocytosis-from-latin-america
#18
Natália Rocha Bedran, Román Carlos, Bruno Augusto Benevenuto de Andrade, Ana Paula Silva Bueno, Mário José Romañach, Cristiane Bedran Milito
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior caused by the accumulation of CD1a(+)/CD207(+) histiocytes, associated with a variable number of eosinophils, lymphocytes, plasma cells and multinucleated giant cells, most commonly observed in male children. LCH is uncommon in the head and neck region, occurring as ulcerated and reddened plaques or nodules that cause destruction of adjacent soft tissues and bone. The exact etiology of LCH is still unknown and controversial, with possible etiologic role of viruses, including Epstein-Barr virus (EBV)...
November 21, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29160138/a-case-of-dedifferentiated-chondrosarcoma-arising-in-the-cricoid-cartilage-that-mimicked-an-aneurysmal-bone-cyst
#19
Lixiao Chen, Ziwei Yu, Rui Jiang, Pin Dong, Bin Shen, Yu Li
Dedifferentiated chondrosarcoma of the larynx is a rare and highly malignant tumor. We present the report of a 59-year-old man with dedifferentiated laryngeal chondrosarcoma, which was difficult to diagnose even under microscopic examination. The original diagnosis was an aneurysmal bone cyst, and the final diagnosis was established only after careful consideration of the imaging, surgical, and microscopic findings. In clinical practice, there are many similarities between dedifferentiated chondrosarcoma and aneurysmal bone cysts...
November 21, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29159783/in-vitro-study-of-the-effects-of-denosumab-on-giant-cell-tumor-of-bone-comparison-with-zoledronic-acid
#20
Isao Shibuya, Masamichi Takami, Arei Miyamoto, Akiko Karakawa, Akira Dezawa, Shigeru Nakamura, Ryutaro Kamijo
Giant cell tumor of bone (GCTB) is a locally aggressive primary bone tumor that contains numerous osteoclasts formed from marrow-derived precursors through receptor activator of nuclear factor κ-B ligand (RANKL), an osteoclast differentiation factor expressed in neoplastic cells of GCTB. Denosumab, a fully human monoclonal antibody targeting RANKL, has recently been used for the treatment of GCTB, and superior treatment effects have been reported. The aim of this work was to elucidate the mechanism of action of denosumab, and the differences between denosumab and zoledronic acid at the level of GCTB cells...
November 20, 2017: Pathology Oncology Research: POR
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