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Giant cell tumor of bone

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https://www.readbyqxmd.com/read/28737756/overexpression-of-zinc-finger-protein-687-enhances-tumorigenic-capability-and-promotes-recurrence-of-hepatocellular-carcinoma
#1
T Zhang, Y Huang, W Liu, W Meng, H Zhao, Q Yang, S-J Gu, C-C Xiao, C-C Jia, B Zhang, Y Zou, H-P Li, B-S Fu
Zinc finger protein 687 (ZNF687), identified as a C2H2 zinc finger protein, has been found to be mutated and upregulated in giant cell tumor of bone and acute myeloid leukemia, suggesting an oncogenic role for ZNF687 in cancer. However, the clinical significance and precise role of ZNF687 in cancer progression are largely unknown. Herein, we report that ZNF687 was markedly upregulated in hepatocellular carcinoma (HCC) cell lines and HCC tissues, and was significantly correlated with relapse-free survival in HCC...
July 24, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28732103/denosumab-current-use-in-the-treatment-of-primary-bone-tumors
#2
Olga D Savvidou, Ioanna K Bolia, George D Chloros, John Papanastasiou, Panagiotis Koutsouradis, Panayiotis J Papagelopoulos
Denosumab, a human monoclonal antibody that inhibits bone resorption by binding on the receptor activator of the nuclear factor kappa-β ligand, has recently emerged as an additional option in the treatment of musculoskeletal osteolytic tumors. This article focuses on the recent literature regarding the effectiveness of denosumab in the management of giant cell tumor, multiple myeloma, aneurysmal bone cyst, and osteosarcoma. The mechanism of action of denosumab in the management of these tumors and the associated side effects are discussed in detail...
July 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28728303/-enhancing-soft-tissue-reattachment-with-artificial-mesh-in-joint-endoprosthetic-reconstruction-for-bone-tumors
#3
J S Lin, R Chen, W Yan, D D Chen
Objective: To investigate the operative method and clinical application of the BARD(®) Mesh in enhancing joint stability and function of endoprosthetic reconstruction for bone tumors. Methods: From Jan 2013 to Jun 2015, the clinical data of 51 patients aged (44.75±23.18) years underwent wide resection of tumor and endoprosthetic reconstruction using the BARD(®) Mesh were collected. Among them, 27 were male and 24 were female. The surgical treatments received by these patients included 5 shoulder arthroplasties, 12 elbow replacements, 12 hip replacements and 32 knee replacements (including 24 femoral tumors and 8 tibial tumors)...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28725958/immune-surveillance-plays-a-role-in-locally-aggressive-giant-cell-lesions-of-bone
#4
REVIEW
Ahmad Al-Sukaini, Francis J Hornicek, Zachary S Peacock, Leonard B Kaban, Soldano Ferrone, Joseph H Schwab
BACKGROUND: Giant cell lesions are locally aggressive intraosseous neoplasms with capacity to metastasize. The role of immune surveillance in the pathophysiology of giant cell lesions is poorly understood, and understanding what role the immune system plays in giant cell lesions may lead to the development of more effective treatment. The aim of this study was to explore the role of immune surveillance in giant cell lesions by examining the expression of the HLA class I and class II antigens and tumor infiltrating lymphocytes...
July 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28725507/giant-cell-tumor-of-the-capitate-treated-with-excision-and-midcarpal-fusion
#5
Ayat Allah Oufkir, Cyril Lazerges, Bertrand Coulet, Michel Chammas
Background  Giant cell tumor (GCT) of bone is rare in the carpus, and only 11 cases have been reported in the capitate bone. The problem with this location is the high recurrence rate due to easy extension to the adjacent joint spaces and bones. We describe a case of GCT on the capitate bone and the treatment in comparison with the previously reported cases. Case Description  The case report concerns a 48-year-old woman with a GCT of the capitate diagnosed on curettage. The treatment consisted of large resection with the lunatum and third metacarpal arthrodesis, with a successful union at 2 years follow-up, no recurrence, and an improved function of the wrist...
August 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28721660/clinicopathologic-and-molecular-characteristics-of-familial-cherubism-with-associated-odontogenic-tumorous-proliferations
#6
Prokopios P Argyris, Rajaram Gopalakrishnan, Ying Hu, Ernst J Reichenberger, Ioannis G Koutlas
Cherubism is a rare autosomal dominant condition affecting the jaws and caused by mutations in the gene encoding for the adapter protein SH3BP2 that maps to chromosome 4p16.3. Cherubism is characterized by symmetrically developing bone lesions in the maxilla and mandible. The lesions have been radiographically and histopathologically well-described. Here, we present a family with cherubism with two of its members featuring odontogenic tumorous proliferations in association with persistent central giant cell lesions (CGCL)...
July 18, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28719994/giant-cell-tumor-of-the-metacarpal-case-report
#7
Laura W Lewallen, Eric R Wagner, Steven L Moran
BACKGROUND: Giant cell tumor (GCT) of bone is a benign, though locally aggressive tumor, classically described as an eccentric lytic lesion, often with cortical expansion and destruction. It typically involves the metaphysis or epiphysis of long bones in skeletally mature patients, with a slight female predominance. The incidence in the small bones of the hand has been reported to be 2% to 5%. METHODS: Treatment options have evolved in recent years, and currently include intralesional curettage with or without adjuvant therapy, wide resection, and occasionally amputation...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28698814/a-patient-matched-entire-first-metacarpal-prosthesis-in-treatment-of-giant-cell-tumor-of-bone
#8
Thipachart Punyaratabandhu, Boonrat Lohwongwatana, Chedtha Puncreobutr, Arkaphat Kosiyatrakul, Puwadon Veerapan, Suriya Luenam
Giant cell tumor of the bones occurring in the first metacarpals frequently requires entire metacarpal resection due to the aggressive nature and high rate of recurrence. Bone reconstruction can be performed with autogenous bone grafts. Here we describe a new technique of reconstruction using a patient-matched three-dimensional printed titanium first metacarpal prosthesis. This prosthesis has a special design for ligament reconstruction in the proximal and distal portions. Good hand function and aesthetic appearance were maintained at a 24-month follow-up visit...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28687009/post-surgery-fluids-promote-transition-of-cancer-stem-cell-to-endothelial-and-akt-mtor-activity-contributing-to-relapse-of-giant-cell-tumors-of-bone
#9
Flavio Fazioli, Gianluca Colella, Roberta Miceli, Mariano Giuseppe Di Salvatore, Michele Gallo, Serena Boccella, Annarosaria De Chiara, Carlo Ruosi, Filomena de Nigris
Giant cell tumors of bone (GCTB) are rare sarcomas with a high rate of unpredictable local relapse. Studies suggest that surgical methods affect recurrence, supporting the idea that local disease develops from re-growth of residual cancer cells. To identify early prognostic markers of individual risk of recurrence, we evaluated the effect of post-surgery fluids from a cohort of GCTB patients on growth of primary and established sarcoma cell lines, and mice xenographts. Post-surgery fluids increased cell growth and enhanced expression of CD44++, the principal receptor for the extracellular matrix component hyaluronan and the mesenchymal stem marker CD117+...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28671156/overview-of-extremity-musculoskeletal-neoplasms-at-the-ahmadu-bello-university-teaching-hospital-zaria-nigeria
#10
Maitama Mohammed Inuwa, Lawal Yau Zakariyau, Dahiru I Ismail, Ejagwulu S Friday, Aniko A Ibrahim, Abdulmalik A Mohammed
BACKGROUND: The burden of managing patients with musculoskeletal neoplasms in the West African sub-region is quite significant. This is largely due to late presentation, delay in making diagnosis, and failure of obtaining consent to certain surgical procedures. Improvements in diagnosis and treatment over the years have however increased life and limb survival for many patients. This study was aimed at evaluating the clinicopathologic pattern of neoplasm as it affects the upper and lower limbs with a view to determining the most common types, the most involved sites of the body and the age at presentation of these tumors...
July 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28670703/tgf-%C3%AE-induced-par-1-expression-promotes-tumor-progression-and-osteoclast-differentiation-in-giant-cell-tumor-of-bone
#11
Ting Wang, Jian Jiao, Hao Zhang, Wang Zhou, Zhenxi Li, Shuai Han, Jing Wang, Xinghai Yang, Quan Huang, Zhipeng Wu, Wangjun Yan, Jianru Xiao
Although protease activated receptor-1 (PAR-1) has been confirmed as an oncogene in many cancers, the role of PAR-1 in giant cell tumor (GCT) of bone has been rarely reported. The mechanism of PAR-1 in tumor-induced osteoclastogenesis still remains unclear. In the present study, we detected that PAR-1 was significantly upregulated in GCT of bone compared to normal tissues, while TGF-β was also overexpressed in GCT tissues and could promote the expression of PAR-1 in a dose and time dependent manner. By using the luciferase reporter assay, we found that two downstreams of TGF-β, Smad3 and Smad4, could activate the promoter of PAR-1, which might explain the mechanism of TGF-β induced PAR-1 expression...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28666271/the-distinct-clinical-features-of-giant-cell-tumor-of-bone-in-pagetic-and-non-pagetic-patients-are-associated-with-genetic-biochemical-and-histological-differences
#12
Giuseppina Divisato, Federica Scotto di Carlo, Laura Pazzaglia, Riccardo Rizzo, Domenico A Coviello, Maria Serena Benassi, Piero Picci, Teresa Esposito, Fernando Gianfrancesco
Giant Cell Tumor of Bone (GCT) is a tumor characterized by neoplastic mesenchymal stromal cells and a high number of osteoclast-like multinucleated giant cells. Rarely, GCT could arise in bones affected by Paget's disease of bone (GCT/PDB). Although it is already known that GCT/PDB and GCT show a different clinical profile regarding the age-onset and skeletal localization, our deep clinical comparison between the two GCT/PDB and GCT cohorts, permitted us to identify additional differences (e.g. focality, ALP serum levels, the 5-year survival rate and the familial recurrence), strongly suggesting a different molecular basis...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28666253/tgf-%C3%AE-2-induced-angptl4-expression-promotes-tumor-progression-and-osteoclast-differentiation-in-giant-cell-tumor-of-bone
#13
Bo Li, Ming Qian, Hao Cao, Qi Jia, Zhipeng Wu, Xinghai Yang, Tianyi Ma, Haifeng Wei, Tianrui Chen, Jianru Xiao
Although emerging studies have implicated that Aiopoietin-like 4 Protein (ANGPTL4) is related to the aggressiveness and metastasis of many tumors, the role of ANGPLT4 in giant cell tumor (GCT) of bone was rarely investigated. The mechanism of ANGPLT4 in tumor-induced osteoclastogenesis still remains unclear. In this study, we first demonstrated that ANGPTL4 was highly expressed in GCT compared to normal tissues, while we showed that TGF-β2 released by osteoclasts induced bone resorption could increase the expression of ANGPTL4 in GCTSCs...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28658169/imaging-features-for-diffuse-type-tenosynovial-giant-cell-tumor-of-the-temporomandibular-joint-a-case-report
#14
Yan Hu, Bin Kuang, Yue Chen, Jian Shu
RATIONALE: The tenosynovial giant cell tumor (TGCT) is a benign but locally aggressive tumor that arises from the synovial membrane of joints, tendon sheaths, and bursae. Although any joint can be affected, involvement of the temporomandibular joint (TMJ) was reported very rarely, and there is no relevant report on F-FDG PET/computerized tomography (CT). PATIENT CONCERNS AND DIAGNOSES: We present here a rare case of diffuse-type of TGCT (D-TGCT) arising from the right TMJ in a 74-year-old woman...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28650536/surveillance-for-lung-metastasis-from-giant-cell-tumor-of-bone
#15
Mamer Rosario, Han-Soo Kim, Ji Yeon Yun, Ilkyu Han
BACKGROUND AND OBJECTIVES: Literature on surveillance for lung metastasis from giant cell tumor of bone (GCTB) is scarce. We aimed to develop one by determining: (1) the optimal surveillance schedule by analyzing time-to-event data, taking into account the predictive factors, and (2) the effective diagnostic modality. METHODS: A total of 333 patients who underwent surgery for GCTB were followed for at least 2 years. All had chest radiography, and 169 had additional CT for surveillance...
June 26, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28644557/selective-arterial-embolization-for-the-treatment-of-sacral-and-pelvic-giant-cell-tumor-a-systematic-review
#16
REVIEW
Shao-Hui He, Wei Xu, Zheng-Wang Sun, Wei-Bo Liu, Yu-Jie Liu, Hai-Feng Wei, Jian-Ru Xiao
Giant cell tumor of the bone (GCTB) is a locally aggressive tumor with a certain distant metastatic rate. For sacral GCT (SGCT) and pelvic GCT (PGCT), surgery has its limitations, especially for unresectable or recurrent tumors. Selective arterial embolization (SAE) is reported to be an option for treatment in several cases, but there are few systematic reviews on the effects of SAE on SGCT and/or PGCT. Medline and Embase databases were searched for eligible English articles. Inclusion and exclusion criteria were conducted before searching...
May 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28643220/denosumab-an-emerging-therapy-in-pediatric-bone-disorders
#17
REVIEW
Alison M Boyce
PURPOSE OF REVIEW: Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS: Considerable safety and efficacy data exists for denosumab treatment of adults with osteoporosis, bone metastases, and giant cell tumors. Pediatric data is limited; however, evidence suggests denosumab may be beneficial in decreasing bone turnover, increasing bone density, and preventing growth of certain skeletal neoplasms in children...
June 22, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28639531/outcome-of-bone-recycling-using-liquid-nitrogen-as-bone-reconstruction-procedure-in-malignant-and-recurrent-benign-aggressive-bone-tumour-of-distal-tibia-a-report-of-four-cases
#18
Eka Wiratnaya I Gede, Arrisna Artha Ida Ayu, Yudhi Setiawan I Gn, Wien Aryana Ign, Suyasa I Ketut, Siki Kawiyana I Ketut, Astawa Putu
Amputation still considered as primary choice of malignancy treatment in distal tibia. Bone recycling with liquid nitrogen for reconstruction following resection of malignant bone tumours offers many advantages. We presented four patients with osteosarcoma, Ewing sarcoma, adamantinoma and recurrent giant cell tumour over distal tibia. All of the patients underwent wide excision and bone recycling using liquid nitrogen as bone reconstruction. The mean functional Musculoskeletal Tumor Society (MSTS) score was 75% with no infection and local recurrent...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28633039/giant-cell-tumor-of-bone-with-pathological-evidence-of-blood-vessel-invasion
#19
Shadi Khalil, Rachana Yendala, Nicholas D'Cunha, Fred Hardwicke, Mohamed Shanshal
Giant cell tumor of bone is a rare but aggressive benign tumor that arises at the end of long tubular bones. The tumor rarely metastasizes; however, we report a case in which a giant cell tumor of bone presented with progressive pulmonary metastases. There has been no clear pathologic evidence of the definitive cause or route of metastasis. In our case, the primary tumor site was located in the left femur with pathological evidence of blood vessel invasion. The histological and pathological features of this entity are discussed in this letter to the editor...
June 15, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28626415/a-case-of-childhood-onset-giant-cell-tumor-that-caused-optic-nerve-atrophy-in-both-eyes
#20
Masahiro Tonari, Junko Matsuo, Hidehiro Oku, Jun Sugasawa, Tsunehiko Ikeda, Kazunori Tatsuzawa, Tomoaki Fujita
PURPOSE: The purpose of this study was to report the case of a female patient who had a giant cell tumor in the paranasal sinus during childhood, and while undergoing multiple resection surgeries experienced optic atrophy in both eyes. CASE PRESENTATION: This study involved a 35-year-old woman who was previously diagnosed with a giant cell tumor of the paranasal sinus bone at age 13. A CT scan revealed a large tumor extending from the sphenoid sinus to the ethmoid sinus...
May 2017: Case Reports in Ophthalmology
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