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Giant cell tumor of bone

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https://www.readbyqxmd.com/read/28210962/giant-cell-tumor-of-the-frontal-bone-presenting-as-an-orbital-mass
#1
Peter H Tang, Pradeep Mettu, Amanda C Maltry, Andrew R Harrison, Ali Mokhtarzadeh
A 10-year-old male was referred for evaluation of a right orbital mass present for 3 weeks with associated tenderness to palpation. Magnetic resonance imaging (MRI) and computed tomography imaging (CT) revealed a solid mass centered in the frontal bone with extension into the orbit. Surgical excision and histologic analysis of the lesion was consistent with a diagnosis of a Giant Cell Tumor (GCT) of the frontal bone. The patient tolerated the procedure without complication and is doing well upon follow-up.
February 16, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28210458/osseous-oral-hyaline-ring-granuloma-mimicking-a-mandible-tumor-in-a-child-with-congenital-agenesis-of-the-corpus-callosum
#2
Rodrigo Neves-Silva, Camilla-Borges Ferreira-Gomes, Natalia Palmier, Marcelo Brum-Corrêa, Oslei Paes-Almeida, Marcio Ajudarte-Lopes, Pablo Agustin-Vargas, Alan-Roger Santos-Silva
BACKGROUND: Hyaline ring granuloma (HRG) of the oral cavity is an uncommon disorder considered to be a foreign-body reaction resulting from implantation of food vegetable particles. Microscopically, it is characterized by the presence of structures of hyaline rings in an inflamed fibrous tissue background, which contains multinucleated giant cells. MATERIAL AND METHODS: We present the case of a 4-year-old boy diagnosed with a mandible osseous HRG, which showed clinical and tomographic aspects suggestive of an aggressive bone tumor...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28208958/radiological-and-histopathological-outcome-of-giant-cell-tumor-of-femur-with-denosumab-treatment-a-case-report
#3
Preethi Dileep Menon, R Krishnakumar, Annie Jojo
Giant Cell Tumour of Bone (GCTB) is a benign but locally aggressive osteolytic skeletal neoplasm of young adults consisting of giant cells expressing RANK (Receptor Activator of Nuclear Factor-κB) and mesenchymal spindle-like stromal cells expressing RANKL (RANK ligand). The interaction of these cells leads to bone resorption. Recently, the RANKL inhibitor, denosumab, has demonstrated activity against giant-cell tumours. The current article reports a case of a Giant cell tumour of left distal femur with pathological fracture...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28197783/freezing-nitrogen-ethanol-composite-may-be-a-viable-approach-for-cryotherapy-of-human-giant-cell-tumor-of-bone
#4
Po-Kuei Wu, Cheng-Fong Chen, Jir-You Wang, Paul Chih-Hsueh Chen, Ming-Chau Chang, Shih-Chieh Hung, Wei-Ming Chen
BACKGROUND: Liquid nitrogen has been used as adjuvant cryotherapy for treating giant cell tumor (GCT) of bone. However, the liquid phase and ultrafreezing (-196° C) properties increase the risk of damage to the adjacent tissues and may lead to perioperative complications. A novel semisolid cryogen, freezing nitrogen ethanol composite, might mitigate these shortcomings because of less-extreme freezing. We therefore wished to evaluate freezing nitrogen ethanol composite as a coolant to determine its properties in tumor cryoablation...
February 14, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28195259/telangiectatic-osteosarcoma-of-the-rib-a-rare-entity-and-a-potential-diagnostic-pitfall
#5
I Saguem, L Ayadi, R Kallel, S Charfi, I Bahri, N Gouiaa, T Sellami-Boudawara
Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. The rib involvement is very infrequent. We present a case of TOS of the rib that posed a diagnostic difficulty owing to its unusual location and to its resemblance to giant cell tumor and aneurysmal bone cyst...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28188337/giant-cell-tumor-of-the-bone-aggressive-case-initially-treated-with-denosumab-and-intralesional-surgery
#6
Donald von Borstel, Roberto A Taguibao, Nicholas A Strle, Joseph E Burns
Giant cell tumor of the bone (GCTB) is a locally aggressive benign tumor, which has historically been treated with wide surgical excision. We report a case of a 29-year-old male with histology-proven GCTB of the distal ulna. The initial imaging study was a contrast-enhanced magnetic resonance imaging (MRI) examination of the left wrist, which was from an outside facility performed before presenting to our institution. On the initial MRI, the lesion had homogenous T2-hyperintense and T1-hypointense signal with expansive remodeling of the osseous contour...
April 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28188186/nccn-guidelines-insights-bone-cancer-version-2-2017
#7
J Sybil Biermann, Warren Chow, Damon R Reed, David Lucas, Douglas R Adkins, Mark Agulnik, Robert S Benjamin, Brian Brigman, G Thomas Budd, William T Curry, Aarati Didwania, Nicola Fabbri, Francis J Hornicek, Joseph B Kuechle, Dieter Lindskog, Joel Mayerson, Sean V McGarry, Lynn Million, Carol D Morris, Sujana Movva, Richard J O'Donnell, R Lor Randall, Peter Rose, Victor M Santana, Robert L Satcher, Herbert Schwartz, Herrick J Siegel, Katherine Thornton, Victor Villalobos, Mary Anne Bergman, Jillian L Scavone
The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's guideline recommendations for treating Ewing sarcoma. The data underlying these treatment recommendations are also discussed.
February 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28185423/granulocyte-colony-stimulating-factor-producing-pancreatic-anaplastic-carcinoma-in-ascitic-fluid-at-initial-diagnosis-a-case-report
#8
Nao Kubota, Yoshiki Naito, Akihiko Kawahara, Tomoki Taira, Tomohiko Yamaguchi, Tomoko Yoshida, Hideyuki Abe, Yorihiko Takase, Chihiro Fukumitsu, Kazuya Murata, Yusuke Ishida, Yoshinobu Okabe, Yoshizo Kimura, Masahiko Tanigawa, Yutaro Mihara, Masamichi Nakayama, Rin Yamaguchi, Jun Akiba, Hirohisa Yano
Granulocyte colony-stimulating factor (G-CSF)-producing pancreatic tumors are extremely rare. These tumors have an aggressive clinical course and no established treatment. Here, we report an autopsy case of G-CSF-production in pancreatic anaplastic carcinoma (PAC). A 72-year-old woman presented with a large pancreatic head mass and multiple liver metastases. Laboratory data showed leukocytosis (leukocyte count 113.3 × 10(3) /µL) and high serum G-CSF levels (441 pg/mL; normal range: <39.0 pg/mL). The ascitic fluid was submitted to our pathology laboratory at initial diagnosis...
February 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28164066/giant-cell-tumor-developing-in-paget-s-disease-of-bone-a-case-report-with-review-of-literature
#9
Vivek Verma, Ajay Puri, Sanket Shah, Bharat Rekhi, Ashish Gulia
INTRODUCTION: Paget's disease of bone (PDB) is a disease of elderly characterized by disorganized bone remodeling. Development of secondary neoplasm in PDB is a known but rare phenomenon. Development of giant cell tumor in PDB (GCT-PDB) is extremely rare, and little is known about its etiopathogenesis and management. We present a case report of such a development with a review of the literature and the role of various new modalities of treatment available in the management of this rare condition...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28164048/rare-giant-cell-tumor-of-olecranon-bone
#10
Pawan Goyal, Vishal Gautam, Narender Saini, Yogesh Sharma
INTRODUCTION: Giant cell tumor (GCT) is a bone tumor involving epiphyseal area of bone abutting the subchondral bone. Commonly found in long bones such as proximal tibia and distal femur. We report a case of GCT of olecranon bone in a 23-year-old male. CASE REPORT: A 23-year-old patient presented to our outpatient department with pain and mild swelling at the elbow from last 2 to 3 months. On examination, it was seen that there was a moderate swelling at the tip of the olecranon...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28163523/primary-sacral-hydatid-cyst-mimicking-a-neurogenic-tumor-in-chronic-low-back-pain-case-report-and-review-of-the-literature
#11
Manuel Segura-Trepichio, Jose Manuel Montoza-Nuñez, David Candela-Zaplana, Josefa Herrero-Santacruz, Fernando Pla-Mingorance
Hydatid disease is caused by infection of Echinococcus granulosus. Bone hydatid cyst presentation without hepatic affectation is infrequent and occurs in 0,5-2% of cases. This rare condition makes clinicians not always aware of the disease, and as a result, misdiagnosis of spinal echinococcosis is common. We present a case of a 48-year-old female patient with primary sacral hydatidosis. Chronic low back pain radiating to the left buttock was the only symptom. The magnetic resonance imaging (MRI) suggested a neurogenic tumor versus giant cell tumor...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28153429/patients-with-benign-hand-tumors-are-indicated-for-surgery-according-to-patient-rated-outcome-measures
#12
Michiro Yamamoto, Tadahiro Natsume, Shigeru Kurimoto, Katsuyuki Iwatsuki, Takanobu Nishizuka, Michael T Nolte, Hitoshi Hirata
INTRODUCTION: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 questionnaire. METHODS: In total, 304 patients who underwent surgery for benign bone and soft tissue tumors of the upper limb were included. Tumors were classified into three size groups: <1 cm, 1-3 cm, and >3 cm. Tumors were divided with respect to location: digit, hand, wrist, forearm, elbow, upper arm, or axilla...
January 9, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28146024/en-bloc-resection-versus-intralesional-surgery-in-the-treatment-of-giant-cell-tumor-of-the-spine
#13
Raphaële Charest-Morin, Charles G Fisher, Peter P Varga, Ziya L Gokaslan, Laurence D Rhines, Jeremy J Reynolds, Mark B Dekutoski, Nasir A Quraishi, Mark H Bilsky, Michael G Fehlings, Dean Chou, Niccole M Germscheid, Alessandro Luzzati, Stefano Boriani
STUDY DESIGN: Multicenter, ambispective observational study OBJECTIVE.: To quantify local recurrence and mortality rates after surgical treatment of spinal giant cell tumor and to determine whether en bloc resection with wide/marginal margins is associated with improved prognosis compared to an intra-lesional procedure. SUMMARY OF BACKGROUND DATA: Giant cell tumor of the spine is a rare primary bone tumor known for its local aggressiveness. Optimal surgical treatment remains to be determined...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28142350/giant-cell-tumor-of-distal-radius-treated-with-ulnar-translocation-and-wrist-arthrodesis
#14
Abhijeet Ashok Salunke, Jaymin Shah, Vikas Warikoo, Amit Chakraborty, Harshwardhan Pokharkar, Yongsheng Chen, Manish Pruthi, Jyotindra Pandit
INTRODUCTION: The aim is to analyze the functional outcomes of patients of giant cell tumor (GCT) of distal radius treated with ulnar translocation and wrist arthrodesis. METHODS: Study included 25 patients of aggressive GCT of distal radius, resected and reconstructed using ulnar translocation and wrist arthrodesis. The ulna-carpal radius fixation was performed with plate and screws. The patients were followed to bony union and minimum follow-up was 1 year. RESULT: Twenty-two patients were of Campanacci grade 3 and three patients were of Campanacci grade2...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28116258/recurrent-gct-of-distal-femur-treated-with-resection-arthrodesis-with-non-vascularized-bilateral-fibular-graft-and-a-custom-made-interlock-nail
#15
Tuteja Sanesh, Kale Sachin, Chaudhari Prasad, Dhar Sanjay B
INTRODUCTION: Giant Cell Tumors commonly occur around the knee joint in the age group of 20-30 years. They are treated with intra-lesional curettage or local resection and limb reconstruction. Management of large bone defects after resection is a challenge and is of ten complicated with non-union of grafts, infection and delayed weight bearing. CASE PRESENTATION: A 37-year-old male presented with an aggressive recurrent giant cell tumor of the distal femur. He was and was diagnosed with a GCT of the left distal femur 2 years ago for which he was treated with an intralesional curettage and Poly methylmetacrylate implantation...
July 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28109658/intra-articular-ectopic-ossification-associated-with-denosumab-administration-for-giant-cell-tumor-of-bone-with-intra-articular-pathological-fracture
#16
Eiji Osaka, Yuki Okamura, Yukihiro Yoshida, Masahiko Sugitani, Yasuaki Tokuhashi
No abstract text is available yet for this article.
January 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28105885/denosumab-in-patients-with-giant-cell-tumor-of-bone-in-norway-results-from-a-nationwide-cohort
#17
Kjetil Boye, Nina Louise Jebsen, Olga Zaikova, Heidi Knobel, Ayca M Løndalen, Clement S Trovik, Odd R Monge, Kirsten Sundby Hall
BACKGROUND: Denosumab is a relatively new treatment option for patients with giant-cell tumor of bone (GCTB). The purpose of this study was to report the results for patients treated in Norway. MATERIALS AND METHODS: Patients treated with denosumab for GCTB were identified from the clinical databases at the Norwegian sarcoma reference centers. Data were retrieved from the clinical databases and supplemented by retrospective review of patient records. Denosumab was given as a subcutaneous injection every 4 weeks with loading doses on day 8 and 15 in cycle 1...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28101196/denosumab-treatment-of-inoperable-or-locally-advanced-giant-cell-tumor-of-bone
#18
Aneta Borkowska, Tomasz Goryń, Andrzej Pieńkowski, Michał Wągrodzki, Ewelina Jagiełło-Wieczorek, Paweł Rogala, Milena Szacht, Piotr Rutkowski
Giant cell tumor of bone (GCTB) is an osteolytic, locally aggressive tumor that rarely metastasizes and typically occurs in the bones. At present, the primary treatment for GCTB is curettage with local adjuvants. Giant cells express receptor activator of nuclear factor-κB ligand (RANKL). Denosumab, a RANKL inhibitor appears to present an effective therapeutic option in advanced cases of GCTB. The aim of the present study was to confirm the efficacy of denosumab in large group of patients with locally advanced GCTB...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28089322/a-central-giant-cell-granuloma-in-posterior-part-of-maxilla-a-case-report
#19
Priyanka Garg, Jinendra Jain, Nayana De, Kushal Chatterjee
INTRODUCTION: Central Giant Cell Granuloma (CGCG) is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone1. PRESENTATION OF CASE: we are presenting a case of Central Giant Cell Granuloma on Maxilla. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio - nasolabial labial fold resulting in facial asymmetry & Intraoral examination shows a purple expansile mass in the region of upper left 26, 27 and 28 edentulous areas...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28078198/multidisciplinary-approach-to-management-of-temporal-bone-giant-cell-tumor
#20
Taija K Nicoli, Riste Saat, Risto Kontio, Anna Piippo, Maija Tarkkanen, Jussi Tarkkanen, Jussi Jero
Background Giant cell tumors (GCTs) are rare osseous tumors that rarely appear in the skull. Methods We review the clinical course of a 28-year-old previously healthy woman with a complicated GCT. Results The reviewed patient presented with a middle cranial fossa tumor acutely complicated by reactive mastoiditis. Left tympanomastoidectomy was performed for drainage of the mastoiditis and for biopsies of the tumor. Due to the challenging tumor location, the patient was treated with denosumab, a fully humanized monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, for 7 months, which resulted in significant preoperative tumor shrinkage...
July 2016: Journal of Neurological Surgery Reports
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