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Giant cell tumor of bone

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https://www.readbyqxmd.com/read/27910166/anchored-multiplex-pcr-for-targeted-next-generation-sequencing-reveals-recurrent-and-novel-usp6-fusions-and-upregulation-of-usp6-expression-in-aneurysmal-bone-cyst
#1
Natalya V Guseva, Omar Jaber, Munir R Tanas, Aaron A Stence, Ramakrishna Sompallae, Jenna Schade, Allison N Fillman, Benjamin J Miller, Aaron D Bossler, Deqin Ma
Primary aneurysmal bone cyst (ABC) is a neoplastic process due to recurrent translocations involving the USP6 gene. By fluorescence in situ hybridization, up to 69% of primary ABCs harbored USP6 translocations; no USP6 translocation was found in secondary ABC or giant cell tumor of bone (GCT). GCT can recur locally, metastasize to the lungs in some cases, and rarely undergo malignant transformation. Differentiating primary ABC from its mimics is important for treatment and prognosis. We evaluated USP6 fusion and expression in 13 cases of primary and 1 case of secondary ABC, and 9 cases of GCT using nucleic acid extracted from formalin-fixed, paraffin-embedded tissue and a next generation sequencing (NGS)-based assay...
November 7, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27907820/preauricular-pilomatricoma-an-uncommon-entity-in-a-dental-pediatric-patient
#2
Poyzan Bozkurt, Mehmet Eray Kolsuz, Ömer Günhan, Erdal Erdem, Kaan Orhan
INTRODUCTION: Pilomatricomas are benign follicular skin appendage tumors, commonly occurring in children and young adults. Most patients admit to dermatologists to seek treatment and are well known by them; however, dental professionals, especially pediatric dentists are not familiar with these tumors. PRESENTATION OF CASE: This report presents a 16-year-old female with preauricular pilomatricoma, located beneath the overlying skin of the temporomandibular region...
November 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27900098/clinical-effects-of-three-surgical-approaches-for-a-giant-cell-tumor-of-the-distal-radius-and-ulna
#3
Jing Zhang, Yi Li, Dongqi Li, Junfeng Xia, Su Li, Shunling Yu, Yedan Liao, Xiaojuan Li, Huilin Li, Zuozhang Yang
The aim of the present study was to assess the curative effects of three surgical approaches for a giant cell tumor (GCT) of the distal radius and ulna. A total of 27 patients with GCT on distal radius and ulnas (7 and 20, respectively), confirmed by biopsy, were treated with individualized treatment regimens, according to the Campanacci's grade system: i) Curettage plus inactivated tumor bed and allogeneic bone graft/bone cement augmentation for Campanacci's grade I GCT of the distal radius and ulna (Group A); ii) simple en bloc resection for Campanacci's grade II and III GCT of the distal ulna (Group B); iii) en bloc resection and reconstruction with non-vascularized fibular autograft/allogeneic bone graft for Campanacci's II and III GCT of the distal radius (Group C)...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27899694/non-small-cell-carcinoma-of-the-lung-with-osteoclast-like-giant-cells
#4
Hans Helmut Dahm
Carcinomas of the lung with benign osteoclast-like giant cells are rare. A literature search showed only 8 previously reported examples. These tumors resemble a giant cell tumor of bone. Many of these tumors, which occur in most epithelium-containing organs, are composed of an undifferentiated, sarcomatoid component that contains benign osteoclast-like giant cells and a conventional carcinoma. In some tumors the epithelial origin may be revealed by immunohistochemistry only; others lack any evidence of an epithelial component...
November 29, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27888510/tenosynovial-giant-cell-tumors-of-the-temporomandibular-joint-and-lateral-skull-base-review-of-11-cases
#5
Matthew L Carlson, L Mariel Osetinsky, Eran E Alon, Carrie Y Inwards, John I Lane, Eric J Moore
OBJECTIVES: To elucidate the clinical behavior, treatment, and outcomes of tenosynovial giant cell tumors (TGCT) involving the temporomandibular joint (TMJ) and adjacent temporal bone. STUDY DESIGN: Retrospective case series with histopathologic review. METHODS: A retrospective chart review was performed identifying and collecting data from all cases of TGCT involving the TMJ and adjacent temporal bone that were treated at the authors' center between January 1960 and December 2015...
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27885101/giant-cell-tumor-of-talus-t-construct-method-of-bone-grafting
#6
Abhijeet B Kadam, Anoop C Dhamangaonkar
: Giant cell tumor (GCT) or osteoclastoma is a benign, locally aggressive tumor with a tendency to recur. Giant cell tumors typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and involvement of talus is rare. The authors present a case of GCT of the talar body in a 21-year-old man, which was diagnosed radiologically by the presence of a well-defined osteolytic lesion involving more than half of the talar body with thinning of the cortices...
November 23, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27869449/-diffuse-tenosynovial-giant-cell-tumor-of-the-cervical-spine-destroying-vertebra-c6-a%C3%A2-case-report
#7
Zdeněk Kinkor, Tomáš Svoboda, Petr Grossman, David Bludovský, Filip Heidenreich, Andrej Švec, Iveta Mečiarová
Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27866665/-giant-cell-reparative-tumor-an-exceptional-differential-diagnosis-for-a-lytic-lesion-of-the-temporal-bone
#8
F Bernard, L Troude, C Bouvier, P-H Roche
BACKGROUND AND IMPORTANCE: Giant cell reparative granuloma is a very rare benign osteolytic lesion. It typically arises in the mandible and rarely involves the skull. CLINICAL PRESENTATION: A 25-year-old male was admitted in August 2002 for a painless left preauricular mass of several months duration. CT scan revealed an osteolytic extradural lesion located in the temporal bone, with extension to infratemporal fossa. We performed a surgical partial resection of the tumour via a frontotemporal approach...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27862328/primary-giant-cell-tumor-of-the-female-breast-a-diagnostic-red-herring-with-therapeutic-implications
#9
Balan Louis Gaspar, Saniya Sharma, Rajinder Singh, Rakesh Kumar Vasishta
Primary giant cell tumor of the female breast is extremely rare. Major diagnostic difficulty is encountered not only by the surgeon but also by the radiologist and pathologist. Pathologically, it is similar to the bone and soft tissue counterparts. However, this is not always true. We describe a patient presenting clinically as cystosarcoma phyllodes and histopathological examination revealed a primary giant cell tumor which was confirmed by immunohistochemistry and electron microscopy. Interestingly, an intimate relationship between the mononuclear component of the tumor cells with eosinophils and mast cells was observed electron microscopically...
November 16, 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27862217/genome-wide-transcriptome-profiling-of-the-neoplastic-giant-cell-tumor-of-bone-stromal-cells-by-rna-sequencing
#10
Carol Py Lau, Jamie Sl Kwok, Joseph Cc Tsui, Lin Huang, Kevin Y Yang, Stephen Kw Tsui, Shekhar Madhukar Kumta
Giant cell tumor of bone (GCTB) is the most common non-malignant primary bone tumor reported in Hong Kong. Failure of treatment in advanced GCTB with aggressive local recurrence remains a clinical challenge. In order to reveal the molecular mechanism underlying the pathogenesis of this tumor, we aimed to examine the transcriptome profiling of the neoplastic stromal cells of GCTB in this study. RNA-sequencing was performed on three GCTB stromal cell samples and one bone marrow-derived MSC sample and 174 differentially expressed genes (DEGs) were identified between these two cell types...
November 15, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27847665/an-unusual-and-complicated-course-of-a-giant-cell-tumor-of-the-capitate-bone
#11
Ingo Schmidt
A 51-year-old female patient presented with a carpal giant cell tumor (GCT) of the right capitate bone. The lesion was initially misdiagnosed as having an osteomyelitis. First, the diagnosis of a benign GCT was confirmed by histological examination. Second, an intralesional curettage and packing of the cavity with cancellous iliac crest bone grafts combined with a fusion of the third carpometacarpal (CMC III) joint were carried out. Third, due to a secondary midcarpal osteoarthritis and a secondary scaphoid nonunion, the CMC III joint fusion plate was removed and the midcarpal joint completely excised...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27827384/recurrence-rates-and-risk-factors-for-primary-giant-cell-tumors-around-the-knee-a-multicentre-retrospective-study-in-china
#12
Pan Hu, Liming Zhao, Huilin Zhang, Xiuchun Yu, Zhen Wang, Zhaoming Ye, Sujia Wu, Shibing Guo, Guochuan Zhang, Jinghua Wang, Xianjia Ning, Yongcheng Hu, Yingze Zhang
Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27823978/clinical-characteristics-and-prognoses-of-six-patients-with-multicentric-giant-cell-tumor-of-the-bone
#13
Chenglei Liu, Yawen Tang, Mei Li, Qiong Jiao, Huizhen Zhang, Qingcheng Yang, Weiwu Yao
Multicentric giant cell tumor of the bone (MGCT) is a rare entity whose radiographic, pathological and biological features remain confusing. We retrospectively reviewed six patients (1 male, 5 female; average age, 22.33 years) treated for confirmed MGCT between 2001 and 2015. The patients' clinical information, images from radiographs (n = 14), CT (n = 13), MRI (n = 8), bone scintigraphy (n = 1) and PET-CT (n = 2), as well as histologic features, treatment and prognosis were analyzed. A total of 17 lesions were detected: 4 around the knee joint, 3 in the greater trochanter and head of the femur, 5 in the small bones of the feet, and 2 in flat bones...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27815993/giant-cell-tumour-of-clavicle-occurrence-of-a-common-tumour-in-a-rare-location
#14
Kavin Khatri, Jagdeep Singh, Anoop Kalia, Anshul Dahuja
INTRODUCTION: The clavicle is rare site of bone tumours. Majority of the tumours of clavicle are malignant and are often misdiagnosed due to low index of suspicion. The oncological patterns of clavicle resemble that of flat bones. CASE PRESENTATION: A 60year old man presented to our centre with pain and swelling over lateral end of left clavicle. After thorough investigation a provisional diagnosis of giant cell tumor was made which was treated with partial claviculectomy...
October 25, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27815654/musculoskeletal-manifestations-of-primary-hyperparathyroidism
#15
REVIEW
Ramesh Pappu, Serge A Jabbour, Antonio M Regianto, Antonio J Reginato
Primary hyperparathyroidism (PHPT) can be associated with a variety of musculoskeletal complaints, which occasionally can be the leading or presenting manifestation. In this paper, we describe the musculoskeletal manifestations observed in patients with primary hyperparathyroidism. Medical record reviews of a select population of 74 patients with primary hyperparathyroidism are seen in a rheumatology practice. Bone manifestations included back pain in 11 patients (15.2 %), generalized bone pain in 7 patients (9...
November 4, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27809843/risks-and-benefits-of-combining-denosumab-and-surgery-in-giant-cell-tumor-of-bone-a-case-series
#16
Daniel A Müller, Giovanni Beltrami, Guido Scoccianti, Domenico A Campanacci, Alessandro Franchi, Rodolfo Capanna
BACKGROUND: The RANK ligand inhibitor denosumab is being investigated for treatment of giant cell tumor of bone, but the available data in the literature remains sparse and controversial. This study analyzes the results of combining denosumab with surgical treatment and highlights possible changes for the oncologic surgeon in daily practice. METHODS: A total of 91 patients were treated surgically for giant cell tumor of bone between 2010 and 2014 in an institution, whereas 25 patients of the total additionally received denosumab and were part of this study...
November 4, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27799977/cytodiagnosis-of-chondromyxoidfibroma-of-the-metatarsal-head-a-case-report
#17
Bushra Siddiqui, ShahbazHabib Faridi, Mohd Faizan, Rana K Sherwani
Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor with a predilection for the bones of lower extremities and about one fourth of the tumors involve the foot. Radiologically, an eccentric lytic lesion with well-defined margins is seen in the metaphysis of the bone. We hereby, report an 18 yr old young male who presented to Orthopedic Outpatient Department, JN Medical College, Aligarh Muslim University, India diagnosed with giant cell tumor of the third metatarsal bone of right foot on radiography but on fine needle aspiration cytology (FNAC) the diagnosis of CMF was made...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27784623/clinical-and-pathological-results-of-denosumab-treatment-for-giant-cell-tumors-of-bone-prospective-study-of-14-cases
#18
Mehmet Ali Deveci, Semra Paydaş, Gülfiliz Gönlüşen, Cenk Özkan, Ömer Sunkar Biçer, Mustafa Tekin
OBJECTIVE: Giant cell tumor of bone (GCT) is a primary, osteolytic, benign tumor of the bone. Surgery is the commonly used treatment; however, recurrence remains a problem. Receptor activator of nuclear factor kappa B (RANKL) is responsible for the formation of osteoclastic cells. Discovery of RANKL and its human monoclonal antibody, denosumab, led to use of denosumab for treatment of GCT. The aim of this study was to evaluate clinical and pathological results of treatment of GCT with denosumab and to assess adverse effect profile and recurrence rate...
October 24, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27779699/differential-expression-of-filamin-b-splice-variants-in-giant-cell-tumor-cells
#19
Joseph Chi-Ching Tsui, Carol Po-Ying Lau, Alex Chun Cheung, Kwok-Chuen Wong, Lin Huang, Stephen Kwok-Wing Tsui, Shekhar Madhukar Kumta
Giant cell tumor of bone (GCT) is the most commonly reported non-malignant bone tumor in Hong Kong. This kind of tumor usually affects people aged 20-40 years. Also, it is well known for recurrence locally, especially when the tumor cannot be removed completely. Filamins are actin-binding proteins which contain three family members, filamin A, B and C. They are the products of three different genes, FLNA, FLNB and FLNC, which can generate various transcript variants in different cell types. In this study, we focused on the effects of FLNBv2 and FLNBv4 toward GCT cells...
October 24, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27771752/multiple-giant-cell-tumors-of-bone-arising-from-multiple-fatty-tumors
#20
Alireza Eajazi, Arvin Kheterpal, Susan Kattapuram, Gunnlaugur Petur Nielsen, Daniel Ira Rosenthal
We describe a patient with a history of giant cell tumor who over the course of 18 years developed multiple fat containing osseous lesions in the pelvis and spine. Two of these lesions subsequently evolved into biopsy proven giant cell tumor of bone. To our knowledge, this phenomenon of giant cell tumors evolving from fat containing lesions has not been described.
October 22, 2016: Skeletal Radiology
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