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Giant cell tumor of bone

Michael K Bokemper, Edgar T Araiza, Kimberly J Templeton, Tyler J Fox
CASE: We describe a 23-year-old man who had multiple recurrences of a giant cell tumor (GCT) of the third metacarpal. Initial treatments consisted of curettage without the use of an adjuvant and bone-grafting. At the time of the latest recurrence, the lesion had extended into the capitate and the trapezoid. Treatment included third-ray resection and limited midcarpal fusion. No local recurrence was identified at more than 1 year after surgery. CONCLUSION: GCTs of the hand should be aggressively treated, but care should be taken to preserve function whenever possible...
March 14, 2018: JBJS Case Connector
Kenji Nakano, Shunji Takahashi
Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. These cancers presented challenges in new drug development partly because of their rarity and heterogeneity. Many new molecular targeting drugs have been tried in the 2010s, and some were approved for bone and soft tissue sarcoma. As one of the first molecular targeted drugs approved for solid malignant tumors, imatinib's approval as a treatment for gastrointestinal stromal tumors (GISTs) has been a great achievement...
March 5, 2018: International Journal of Molecular Sciences
Huiliang Yang, Gi Hye Im, Gunnlaugur Petur Nielsen, Arvin Kheterpal, Joseph H Schwab
Spinal giant cell tumor of bone (GCTB) is a rare benign, but locally aggressive, entity. We report the case of a 40-year-old man diagnosed with GCTB of the thoracic spine. The only symptom upon presentation was progressive back pain with pain radiating to the chest. Magnetic resonance imaging showed that the soft tissue mass extended posteriorly into the spinal canal, causing severe spinal cord compression. We initially treated this case with Decadron (Fresenius kabi, Bad Homburg vor der Hohe, Germany) for 1 week...
March 3, 2018: Skeletal Radiology
Monique J L Mastboom, Floortje G M Verspoor, Daniël Uittenbogaard, Gerard R Schaap, Paul C Jutte, H W Bart Schreuder, Michiel A J van de Sande
BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a rare, benign, monoarticular entity. Many case-series in adults are described, whereas TGCT is only incidentally reported in children. Therefore, its incidence rate and natural history in children are unknown. QUESTIONS/PURPOSES: (1) How many cases have been reported of this condition, and what were their characteristics? (2) What is the standardized pediatric incidence rate for TGCT? (3) Is there a clinical difference in TGCT between children and adults? (4) What is the risk of recurrence after open resection in children compared with adults? METHODS: Data were derived from three sources: (1) a systematic review on TGCT in children, seeking sources published between 1990 and 2016, included 17 heterogeneous, small case-series; (2) the nationwide TGCT incidence study: the Dutch pediatric incidence rate was extracted from this nationwide study by including patients younger than 18 years of age...
February 8, 2018: Clinical Orthopaedics and related Research
G Divisato, F S di Carlo, N Petrillo, T Esposito, F Gianfrancesco
Paget's disease of bone (PDB) is a skeletal disorder whose molecular basis are not fully elucidated. However, 10% of patients show a familial PDB and 35% of them carry mutations in the SQSTM1 gene. We recently reported a founder mutation (p.Pro937Arg) in the ZNF687 gene, underlying PDB complicated by Giant Cell Tumor (GCT/PDB) and rarely occurring in PDB patients without neoplastic degeneration. Since 80% of Italian GCT/PDB patients derive from Avellino, we hypothesized that ZNF687 mutation rate was higher in this region than elsewhere...
March 1, 2018: Clinical Genetics
Lei Yan, Shriram Jakate, Vijaya Reddy, Paolo Gattuso
BACKGROUND: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide. The clinical and cytological features of metastatic HCC have not been well established. METHODS: To determine the clinical and cytological features of metastatic HCC, we retrospectively searched for all HCC metastasis diagnosed by fine needle aspiration or core biopsy. RESULTS: We found 12 bone metastases, 11 intra-abdominal, 4 lung, 3 soft tissue, and 2 lymph node metastases from 32 patients...
March 1, 2018: Diagnostic Cytopathology
Seddighi Afsoun, Seddighi Amir Saied, Nikouei Amir, Javadian Hamed
Giant cell tumors (GCTs) are rare, benign, and locally aggressive primary bone neoplasms. Spine is seldom affected, especially above the level of sacrum. In this report, we describe a case with GCT of the cervical vertebrae which causes collapse of the corpus. A 32-year-old female presented with gradual neck pain and abrupt paresthesia of the left hand. Computed tomography scan showed C6 vertebral collapse and magnetic resonance imaging demonstrated vertebral plana of C6 by a low signal intensity lesion on T1- and T2-weighted images...
January 2018: Asian Journal of Neurosurgery
David Creytens
No abstract text is available yet for this article.
February 27, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Naohiro Makise, Masaya Sekimizu, Takashi Kubo, Susumu Wakai, Shun-Ichi Watanabe, Tomoyasu Kato, Takayuki Kinoshita, Nobuyoshi Hiraoka, Masashi Fukayama, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
AIMS: Extraskeletal osteosarcoma (ESOS) is a sarcoma in the non-skeletal tissue that directly produces neoplastic osteoid or bone. Dedifferentiated liposarcoma (DDLPS) and malignant peripheral nerve sheath tumor (MPNST) are the two most common types of sarcoma that can harbor heterologous osteosarcomatous differentiation. We aimed to determine the potential relationship of ESOS to DDLPS and MPNST. METHODS AND RESULTS: We investigated MDM2 and H3K27me3 status in 19 cases of ESOS, 2 of which contained a low-grade component...
February 28, 2018: Histopathology
Masahiko Takata, Yoshifumi Miyamoto, Yoshimasa Maniwa
We report a rare case of giant cell tumor of the rib. A 33-year-old man was admitted to our hospital because of a recently appearing mass and pain in the right chest wall. Chest computed tomography and magnetic resonance imaging revealed a heterogeneous mass of 8-cm in diameter arising from and destroying the right 7th rib. The tumor was resected together with the 6th, 7th, and 8th ribs and the adjacent muscle and diaphragm. The pathological diagnosis was giant cell tumor of the bone. The patient has been free from recurrence or metastasis for 4 years after the operation...
February 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Ilit Turgeman, Ezequiel Flechter, Eugene Vlodavsky, Daniela Militianu, Zohar Keidar, Elias Haddad, Gil Bar-Sela
Breast carcinoma with osteoclastic giant cells (OGCs) is a rare entity characterized by an admixture of giant cells and malignant epithelial cells within an inflammatory and vascular stroma. Denosumab is a monoclonal antibody that targets the pathway for osteoclast formation and activation, indicated for the prevention of skeletal-related events in patients with bone metastases, as well as for the treatment of giant cell tumor of bone. We report a patient who presented with aggressive bone recurrence of breast cancer 12 years after her original diagnosis, showing a transformed histology that included multinucleated OGCs, and that was refractory to traditional therapy...
February 23, 2018: Anti-cancer Drugs
Zhenhua Zhou, Yan Li, Xudong Wang, Jingjing Hu, Muyu Kuang, Zhiwei Wang, Song Li, Weidong Xu, Jianru Xiao
Giant cell tumor of bone(GCTB) is a special benign tumor with variable aggressiveness and recurrence rate. Increasing evidences suggest that a subset of cells called cancer stem cells (CSCs) are present as cancer-initiating cells in a range of malignant tumors. However, the role of CSCs in benign tumor such as GCTB remains unknown, and the connection between the presence of CSCs and biological characteristics of GCTB is unclear. To investigate this issue, we screened a panel of markers of normal stem cells and CSCs and found ALCAM+ stromal cells possessed characteristics of stem-like cells...
February 20, 2018: Cell Death & Disease
Jisook Yi, Young Han Lee, Sang Kyum Kim, Seung Hyun Kim, Ho-Taek Song, Kyoo-Ho Shin, Jin-Suck Suh
BACKGROUND: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. METHODS: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Chang-Che Wu, Pin-Pen Hsieh
No abstract text is available yet for this article.
February 12, 2018: Journal of Pathology and Translational Medicine
Cory J Broehm, Carrie Y Inwards, Alyaa Al-Ibraheemi, Doris E Wenger, Sarah M Jenkins, Long Jin, Andre M Oliveira, Riyam T Zreik, Jodi M Carter, Jennifer M Boland, Karen J Fritchie
Objectives: Most giant cell tumors of bone (GCTs) occur in patients aged 20 to 40 years. We analyzed features of GCT in patients 55 years or older. Methods: GCTs were examined for fibrosis, matrix, cystic change, histiocytes, mitoses, and necrosis. Clinical/radiologic data were collected. Results: Thirty-four (5%) of 710 GCTs occurred in patients older than 55 years (14/20 male/female; 56-83 years) in long bones (n = 24), vertebrae (n = 6), pelvis (n = 3), and metacarpal (n = 1)...
February 7, 2018: American Journal of Clinical Pathology
Hong-Tao Li, Yong-Zhi Yang, De-Bao Zhang, Gui-Shan Gu
OBJECTIVE: To evaluate the clinical feasibility of particle impaction bone graft and plate internal fixation for the treatment of proximal femoral bone tumors or tumor disease. METHODS: From January 2013 to January 2016 a total of 26 cases of the proximal femur bone tumors or tumor lesions, neither pathological fracture, were retrospectively analyzed, including 12 males and 14 females with an average age of 34.2 years old ranging from 8 to 62 years old. The pathologic result involved fibrous dysplasia in 11 cases, bone isolation bone cyst in 7 cases, giant cell tumors of bone in 3 cases, aneurysm sample bone cyst in 3 cases, non ossifying fibroma in 1 case, benign fibrous histiocytoma in 1 case...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Zhigang Yang, Hong Yao, Fei Fei, Yuwei Li, Jie Qu, Chunyuan Li, Shiwu Zhang
INTRODUCTION: During development and tumor progression, cells need a sufficient blood supply to maintain development and rapid growth. It is reported that there are three patterns of blood supply for tumor growth: endothelium-dependent vessels, mosaic vessels, and vasculogenic mimicry (VM). VM was first reported in highly aggressive uveal melanomas, with tumor cells mimicking the presence and function of endothelial cells forming the walls of VM vessels. The walls of mosaic vessels are randomly lined with both endothelial cells and tumor cells...
February 7, 2018: Journal of Cancer Research and Clinical Oncology
Yogesh Panchwagh, Sujit K Joshi, Parag K Sancheti
Background: Benign aggressive bone lesions of the femoral head and neck are mostly seen in young adults and warrant treatment for pain, impending fracture or established fracture, and disease clearance. It becomes challenging to treat them effectively while attempting salvage of the femoral head and yet achieving long term disease control with minimum complications. We describe our technique and experience in dealing with these lesions which can achieve the above-mentioned goals and can be easily replicated...
January 2018: Indian Journal of Orthopaedics
Zile Singh Kundu, Rajeev Sen, Ankur Dhiman, Pankaj Sharma, Ramchander Siwach, Parveen Rana
Background: Giant cell tumor (GCT) of the bone is known for its locally aggressive behavior and tendency to recur. It is an admixture of rounded or spindle-shaped mononuclear neoplastic stromal cells and multinucleated osteoclast-like giant cells with their proportionate dispersion among the former. Zoledronic acid (a bisphosphonate) is being used in various cancers such as myelomas and metastasis, for osteoporosis with an aim to reduce the resorption of bone, and as an adjuvant treatment for the management of GCT of bone for reduction of local recurrence...
January 2018: Indian Journal of Orthopaedics
Sabrina Abdul Ghani, Wan Faisham Wan Ismail, Md Salzihan Md Salleh, Sahran Yahaya, Zawawi Muhamad Syahrul Fitri
Background: Giant cell tumor (GCT) of bone is a benign locally aggressive primary bone tumor which is risky for local recurrences and pulmonary metastasis. Till date, there are still many uncertainties in predicting the aggressiveness of GCT. We aim to investigate whether receptor activator nuclear kappa-B ligand (RANKL) expression may determine the prognosis of the lesion. Materials and Methods: We examined RANKL expression in 39 patients (21 males, 18 females) by immunohistochemistry...
January 2018: Indian Journal of Orthopaedics
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