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https://www.readbyqxmd.com/read/28381238/homozygous-germ-line-mutation-of-the-pms2-mismatch-repair-gene-a-unique-case-report-of-constitutional-mismatch-repair-deficiency-cmmrd
#1
N C Ramchander, N A J Ryan, E J Crosbie, D G Evans
BACKGROUND: Constitutional mismatch repair deficiency syndrome results from bi-allelic inheritance of mutations affecting the key DNA mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. Individuals with bi-allelic mutations have a dysfunctional mismatch repair system from birth; as a result, constitutional mismatch repair deficiency syndrome is characterised by early onset malignancies. Fewer than 150 cases have been reported in the literature over the past 20 years. This is the first report of the founder PMS2 mutation - NM_000535...
April 5, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28371166/rapid-urine-antibody-test-for-helicobacter-pylori-infection-in-adolescents
#2
Masumi Okuda, Katsuhiro Mabe, Yingsong Lin, Wang Chaochen, Yohei Taniguchi, Mototsugu Kato, Shogo Kikuchi
BACKGROUND: Helicobacter pylori infection is associated with gastric cancer; thus, early diagnosis and treatment are crucial. Since H. pylori infection in adolescents or young adults shows few symptoms, screening tests are necessary for this population. In this study, the accuracy of the rapid urine-H. pylori antibody (u-HpAb) test was evaluated and compared to that of urine and serum H. pylori enzyme-linked immunosorbent assays (u-HpELISA and s-HpELISA, respectively) in junior high school students...
March 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28342130/laparoscopic-proximal-gastrectomy-with-double-tract-reconstruction-is-superior-to-laparoscopic-total-gastrectomy-for-proximal-early-gastric-cancer
#3
Do Hyun Jung, Yoontaek Lee, Dong Wook Kim, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
BACKGROUND: Laparoscopic proximal gastrectomy (LPG) with double tract reconstruction (DTR) is known to reduce reflux symptoms, which is a major concern after proximal gastrectomy. The aim of this study is to compare retrospectively the clinical outcomes of patients undergoing LPG with DTR with those treated by laparoscopic total gastrectomy (LTG). METHODS: Ninety-two and 156 patients undergoing LPG with DTR and LTG for proximal stage I gastric cancer were retrospectively analyzed for short- and long-term clinical outcomes...
March 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28325187/postgastrectomy-syndromes-and-nutritional-considerations-following-gastric-surgery
#4
REVIEW
Jeremy L Davis, R Taylor Ripley
Postgastrectomy syndromes result from altered form and function of the stomach. Gastrectomy disrupts reservoir capacity, mechanical digestion and gastric emptying. Early recognition of symptoms with prompt evaluation and treatment is essential. Many syndromes resolve with minimal intervention or dietary modifications. Re-operation is not common but often warranted for afferent and efferent loop syndromes and bile reflux gastritis. Preoperative nutritional assessment and treatment of common vitamin and mineral deficiencies after gastrectomy can reduce the incidence of chronic complications...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28321154/host-pathogen-interactions-in-helicobacter-pylori-related-gastric-cancer
#5
EDITORIAL
Magdalena Chmiela, Zuzanna Karwowska, Weronika Gonciarz, Bujana Allushi, Paweł Stączek
Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world's population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28226358/-laparoscopic-segmental-gastrectomy-for-early-gastric-cancer
#6
Lai Xu, Beizhan Niu, Xiyu Sun, Menghua Dai, Yi Xiao
OBJECTIVE: To investigate the feasibility of segmental pylorus-reservation gastrectomy in patients with early gastric cancer. METHOD: A retrospective cohort study on clinical data of 6 patients strictly met the criteria of early gastric cancer locating in the middle of the stomach undergoing laparoscopic segmental gastrectomy from January 2014 to April 2016 at Department of General Surgery, Peking Union Medical College Hospital was carried out. Preoperative clinical staging revealed T1N0M0 for all the cases...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28211282/signet-ring-cell-carcinoma-of-the-jejunum-an-uncommon-finding-within-the-reach-of-capsule-endoscopy
#7
José Francisco Juanmartiñena, Marta Montes, Ignacio Fernández-Urién
An 80 year-old female presented with ductal breast carcinoma (stage II) three years ago, complained of asthenia and iron-deficiency anemia. No diagnosis was obtained after conventional endoscopy and iron supplements were indicated. Ten months later visible digestive hemorrhage was presented. Upper and lower endoscopy was repeated but non-diagnosis was obtained. Thus, video capsule endoscopy was indicated identifying a stenotic lesion arising in the mucosa of distal jejunum. Histopathological examination revealed a poorly mucinous differentiated signet-ring cell adenocarcinoma with an intense peri-tumoral lymphoid (Crohn´s-like lymphoid reaction) and lympho-vascular infiltration with no nodal metastases (pT3N0;7ª edition TNM classification)...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28176656/outlook-on-epigenetic-therapeutic-approaches-for-treatment-of-gastric-cancer
#8
Petra Hudler
The incidence of gastric cancer has been declining globally in the last decades. Despite the improvements in the diagnostic procedures, most cases are still detected at advanced stages due to lack of specific symptoms associated with early phases of tumour development. Consequently, gastric cancer poses a major health burden worldwide due to high mortality rates. Continuing advances in high-throughput technologies are revealing an intricate network of genetic and epigenetic changes associated with carcinogenesis...
February 3, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28119270/distribution-of-gastric-carcinoma-in-an-area-with-a-high-prevalence-of-helicobacter-pylori
#9
Javed Yakoob, Syeda Sadia Fatima, Zaigham Abbas, Syed Farrukh Mustafa, Hamza Abdur Rahim Khan, Muhammad Faraz Raghib, Safia Awan, Zubair Ahmad
BACKGROUND/AIMS: South Asia is an enigma for gastric cancer (GC) because it is a low risk region with a high prevalence of Helicobacter pylori (H. pylori) infections. We evaluated the trend of GC clinical presentation and risk factors in patients with dyspeptic symptoms. MATERIALS AND METHODS: The medical records of patients, coded by the international classification of diseases (ICD-10-CM, 2015, Diagnosis Code C16.9) for malignancies of stomach diagnosed by esophagogastroduodenoscopy (EGD) and histopathology, were studied...
March 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28018450/acute-gastritis-associated-with-epstein-barr-virus-infection-in-a-child
#10
Ji Mok Kim, Chun Woo Song, Kyu Sang Song, Jae Young Kim
Infectious mononucleosis is Epstein-Barr virus (EBV) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. Gastrointestinal symptoms of EBV infection are nonspecific and occur rarely. EBV inducing acute gastrointestinal pathology is poorly recognized without suspicion. Careful consideration is needed to diagnose gastric involvement of EBV infection including gastric lymphoma, gastric cancer, and gastritis. A few recent cases of gastritis associated with EBV infection have been reported in adolescents and adults...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27837291/the-psychosocial-impact-of-undergoing-prophylactic-total-gastrectomy-ptg-to-manage-the-risk-of-hereditary-diffuse-gastric-cancer-hdgc
#11
Nina Hallowell, Julia Lawton, Shirlene Badger, Sue Richardson, Richard H Hardwick, Carlos Caldas, Rebecca C Fitzgerald
Individuals identified as at high risk of developing Hereditary Diffuse Gastric Cancer (HDGC) are advised to undergo prophylactic surgery - have their stomach removed - in their early twenties. Research with (older) cancer patients who undergo gastrectomy for curative reasons suggests that gastric resection has a number of physical and psychosocial sequelae. Because it is difficult to extrapolate the findings of studies of older cancer patients to younger healthy patients who are considering prophylactic total gastrectomy (PTG), the aim of this qualitative interview study was to determine the psychosocial implications of undergoing prophylactic surgery to manage genetic risk...
November 11, 2016: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/27803086/advanced-gastric-cancer-linitis-plastica-presented-with-disseminated-intravascular-coagulation
#12
Sehem Ghazala, Jawad Bilal, Irbaz Bin Riaz
An old man was found unconscious; on admission found to have disseminated intravascular coagulation with concern of upper gastrointestinal bleed after he was found to have melena. Esophagogastroduodenoscopy on admission showed diffuse thickened gastric folds, and biopsy showed mucosal oedema. Bone marrow biopsy concerning for lymphoma was obtained showed adenocarcinoma. MRI of the abdomen was significant for diffuse gastric wall thickening. A repeat endoscopic ultrasound showed a diffuse gastric wall thickening of 15 mm and submucosal tunneling technique biopsy suggested high-grade, invasive, signet ring adenocarcinoma of the stomach...
November 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27797257/diagnostic-power-of-blood-parameters-as-screening-markers-in-gastric-cancer-patients
#13
Lukasz Pietrzyk, Zbigniew Plewa, Marta Denisow-Pietrzyk, Remigiusz Zebrowski, Kamil Torres
BACKGROUND: Gastric cancer (GC) is the fifth most common cancer worldwide. Since development is usually asymptomatic, it is generally diagnosed at an advanced stage. The value of screening in patients with nonspecific symptoms for GC is controversial. AIM: The study aimed to evaluate whether hematological parameters (platelet count (PC), mean platelet volume (MPV), MPV/PC ratio, red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)) are useful markers to differentiate between gastric cancer patients and healthy individuals...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27778124/early-detection-of-nonperitoneal-recurrence-may-contribute-to-survival-benefit-after-curative-gastrectomy-for-gastric-cancer
#14
Keiichi Fujiya, Masanori Tokunaga, Rie Makuuchi, Noriyuki Nishiwaki, Hayato Omori, Wataru Takagi, Fumiko Hirata, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: There is no evidence that strict follow-up using cross-sectional imaging after curative gastrectomy benefits survival; however, nonperitoneal recurrence detected early might be treated with additional surgery. The present study examined whether early detection of recurrence by imaging modalities could increase survival, particularly in patients with nonperitoneal recurrence. METHODS: We retrospectively analyzed 218 patients with recurrent gastric cancer after curative gastrectomy performed from 2002 to 2014...
March 2017: Gastric Cancer
https://www.readbyqxmd.com/read/27760960/-analysis-of-short-term-outcomes-after-laparoscopy-assisted-pylorus-preserving-gastrectomy
#15
Junji Kawada, Masaya Nishino, Yohei Hosoda, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Masaki Okuyama, Yongkook Kim, Toshimasa Tsujinaka
BACKGROUND: Pylorus-preserving gastrectomy(PPG)has long been used for the treatment of early gastric cancer, and its survival benefits, postoperative symptoms, and functional outcomes have already been reported in several studies. This study aimed to evaluate the short-term outcomes after LAPPG in our hospital. METHODS: Ten patients with early gastric cancer underwent LAPPG from 2013 to 2015 in our hospital. Their short-term outcomes after LAPPG were retrospectively analyzed...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27752399/single-port-laparoscopic-proximal-gastrectomy-with-double-tract-reconstruction-for-early-gastric-cancer-report-of-a-case
#16
Chang Min Lee, Da Won Park, Do Hyun Jung, You Jin Jang, Jong-Han Kim, Sungsoo Park, Seong-Heum Park
In Korea, proximal gastrectomy has recently attracted attention as a better choice of function-preserving surgery for proximal early gastric cancer than total gastrectomy. Of the various strategies to overcome reflux symptoms from remnant stomach, double tract reconstruction not only reduces the incidence of anastomosis-related complications, but is also sufficiently reproducible as a laparoscopic procedure. Catching up with the recent rise of single-port laparoscopic surgeries, we performed a pure single-port laparoscopic proximal gastrectomy with DTR...
September 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/27751530/postoperative-quality-of-life-after-laparoscopy-assisted-pylorus-preserving-gastrectomy-compared-with-laparoscopy-assisted-distal-gastrectomy-a-cross-sectional-postal-questionnaire-survey
#17
COMPARATIVE STUDY
Kei Hosoda, Keishi Yamashita, Shinichi Sakuramoto, Natsuya Katada, Hiromitsu Moriya, Hiroaki Mieno, Masahiko Watanabe
BACKGROUND: Little is known about postgastrectomy syndrome and quality of life (QOL after laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG). The aim of this study was to assess postgastrectomy syndrome and QOL after LAPPG as compared with laparoscopy-assisted distal gastrectomy with Billroth-I reconstruction (LADGBI). METHODS: Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaires were sent by mail to 167 patients. To balance the characteristics of the groups, propensity score matching was performed...
April 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/27666510/clinical-relevance-of-helicobacter-pylori-virulence-factors-in-iranian-patients-with-gastrointestinal-diseases
#18
REVIEW
Nader Bagheri, Fatemeh Azadegan-Dehkordi, Mahmoud Rafieian-Kopaei, Ghorbanali Rahimian, Majid Asadi-Samani, Hedaytollah Shirzad
Helicobacter pylori (H. pylori) usually colonizes the gastric mucosa of more than 50% of the human population, causing an infection that may appear in early childhood and can persist for life. H. pylori is suggested as the main cause of peptic ulcer and chronic gastritis. It is also associated with gastric cancer. Its severity and symptoms depend on environmental factors, host susceptibility and bacterial components, which allow H. pylori to switch between commensalism and pathogenicity. H. pylori is genetically highly variable, and the variability which affects H...
November 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27624552/a-case-of-undifferentiated-type-mucosal-gastric-cancer-with-multiple-lymph-node-metastases-fulfilling-the-curative-criteria-for-endoscopic-resection-according-to-routine-pathological-analysis
#19
Takao Hara, Tsuyoshi Etoh, Yoshitake Ueda, Yuki Shitomi, Hidefumi Shiroshita, Norio Shiraishi, Tsutomu Daa, Masafumi Inomata
BACKGROUND: Endoscopic resection is accepted as the standard treatment for early mucosal gastric cancer, and its indications have recently been expanded while its long-term outcomes are still unclear. Herein, we present a didactic case of undifferentiated-type mucosal gastric cancer fulfilling the expanded indication and curative criteria for endoscopic submucosal dissection (ESD), having synchronous multiple lymph node metastases. CASE PRESENTATION: A 40-year-old woman was found to have a Helicobacter pylori infection at a standard health check with no abdominal symptoms...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27528456/the-role-of-surgery-in-the-therapeutic-approach-of-gastric-cancer-liver-metastases
#20
REVIEW
Aikaterini Mastoraki, Christina Benetou, Sotiria Mastoraki, Ioannis S Papanikolaou, Nikolaos Danias, Vassilios Smyrniotis, Nikolaos Arkadopoulos
Gastric cancer (GC) currently prevails as the second cause of death by malignancy worldwide. Estimations suggest that 35 % of affected patients appear with synchronous distant metastases. The vast majority of patients present with hepatic metastatic disease, sometimes accompanied by synchronous peritoneal and lung dissemination. The disease mostly remains asymptomatic at an early stage, with few reported cases of incidental abdominal discomfort. As the cancer advances, symptoms such as nausea or vomiting arise, along with indigestion and dysphagia, blood loss in the form of melena or hematemesis, as well as anorexia and weight loss...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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