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https://www.readbyqxmd.com/read/29322372/examination-of-patient-reported-outcomes-in-association-with-tnf-inhibitor-treatment-response-results-from-a-us-observational-cohort-study
#1
Cynthia J Larmore, Natalie N Boytsov, Carol L Gaich, Xiang Zhang, Andre B Araujo, Sabrina Rebello, Bob A Salim, George W Reed, Leslie R Harrold
INTRODUCTION: Implementation of a treat-to-target strategy is challenging when the patient and physician prioritize different goals. This study aimed to "translate" improvements in Clinical Disease Activity Index (CDAI) to concepts that resonate with patients (such as pain, fatigue, morning stiffness) by examining the association between changes in disease activity and patient-reported outcomes (PROs) in a national cohort of patients with rheumatoid arthritis (RA) initiating their first biologic treatment...
January 10, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29317410/derivation-of-a-system-independent-ki-for-pgp-mediated-digoxin-transport-from-system-dependent-ic50-data-by-accounting-for-the-contribution-of-additional-digoxin-transporters
#2
Aqsaa Chaudhry, Git Chung, Adam Lynn, Akshata Yalvigi, Colin Brown, Harma Ellens, Michael O'Connor, Caroline Lee, Joe Bentz
It has been previously demonstrated that IC50 values for inhibition of digoxin transport across confluent cell monolayers are system-dependent. We have applied the structural mass action kinetics model for P-glycoprotein mediated transport of digoxin across confluent cell monolayers to fit IC50 curves for inhibition of digoxin transport. The model fit digoxin IC50 data from a subset of labs participating in the P-gp IC50 Initiative (2 Caco-2 labs, 1 LLC-PK1-hMDR1-NKI lab and 2 MDCKII-hMDR1-NKI labs), as well as IC50 data for inhibition of digoxin transport through monolayers of primary human proximal tubule cells (HPTC) using eight of the same inhibitors...
January 9, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29316657/chemical-characterization-of-a-renoprotective-metabolite-from-termite-associated-streptomyces-sp-rb1-against-cisplatin-induced-cytotoxicity
#3
Dahae Lee, Ki Sung Kang, Hae-Jeung Lee, Ki Hyun Kim
Platinum-based anticancer drug therapies can cause renal damage and apoptotic kidney cell damage. The development of reno- and kidney-protective molecules is therefore urgently required. To address this challenge, we explored secondary metabolites of termite-associated Streptomyces sp. RB1 isolated from the cuticle of the South African termite, Macrotermes natalensis for their renoprotective ability using bioassay-guided fractionation and LLC-PK1 cells. Chemical investigation of the MeOH extract of Streptomyces sp...
January 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29304828/oncogene-addiction-and-radiation-oncology-effect-of-radiotherapy-with-photons-and-carbon-ions-in-alk-eml4-translocated-nsclc
#4
Ying Dai, Quanxiang Wei, Christian Schwager, Janina Hanne, Cheng Zhou, Klaus Herfarth, Stefan Rieken, Kenneth E Lipson, Jürgen Debus, Amir Abdollahi
BACKGROUND: Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhibitor that overcomes Crizotinib resistance. Radiotherapy is an integral therapeutic component of locally advanced lung cancer. Therefore, we sought to investigate the effects of combined radiotherapy and ALK-inhibition via TAE684 in ALK-positive vs. wild type lung cancer cells...
January 5, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29298405/ultrastructural-features-of-alkhumra-hemorrhagic-fever-virus-infection-of-cells-under-in-vivo-and-in-vitro-conditions
#5
Tariq A Madani, El-Tayb M E Abuelzein, Huda Abu-Araki, Soad S Ali, Sawsan M Jalalah, Ahmed M Hassan, Hussein M S Al-Bar, Esam I Azhar
Alkhumra hemorrhagic fever virus (AHFV) is an emerging novel flavivirus that was discovered in Saudi Arabia in 1995. The virus has since caused several outbreaks in the country that resulted in case fatality rates ranging from 1% to 25%. Meager information has been published on the ultrastructural features of the virus on cells under in vitro or in vivo conditions. The present electron microscopic study examined and compared the intracellular growth of the AHFV on the LLC-MK2 cells and brain cells of new born Wistar rats, inoculated intracerebrally...
January 3, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29297783/lang-elvira-2014-managing-your-medical-experience-brookline-ny-hypnagesics-llc-178-pp-11-95-soft-cover-isbn-978-1499705539
#6
Thomas W Wall
No abstract text is available yet for this article.
January 2018: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/29297394/appropriateness-and-timeliness-of-care-seeking-for-complications-of-pregnancy-and-childbirth-in-rural-ethiopia-a-case-study-of-the-maternal-and-newborn-health-in-ethiopia-partnership
#7
Lynn M Sibley, Yared Amare, Solomon Tesfaye Abebe, Mulusew Lijalem Belew, Kemeredin Shiffra, Danika Barry
BACKGROUND: In 2014, USAID and University Research Co., LLC, initiated a new project under the broader Translating Research into Action portfolio of projects. This new project was entitled Systematic Documentation of Illness Recognition and Appropriate Care Seeking for Maternal and Newborn Complications. This project used a common protocol involving descriptive mixed-methods case studies of community projects in six low- and middle-income countries, including Ethiopia. In this paper, we present the Maternal and Newborn Health in Ethiopia Partnership (MaNHEP) case study...
December 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29290440/short-communication-two-dominant-paternal-lineages-for-north-american-jersey-artificial-insemination-sires
#8
C D Dechow, W S Liu, J S Idun, B Maness
Jersey cattle are the second most prominent breed in the United States and represent a growing portion of the dairy cow population in the United States. The objectives of our study were to determine the male lineages of Jersey sires with official genetic evaluations and to determine whether there are differences in sire conception rate among lineages. Paternal lineages back to the 1950s were extracted from genetic evaluation files of the Council on Dairy Cattle Breeding (CDCB, Bowie, MD) for all sires with an official United States genetic evaluation and that were enrolled with the National Association of Animal Breeders (Madison, WI)...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29290023/immunological-hallmarks-of-cis-ddp-resistant-lewis-lung-carcinoma-cells
#9
Olexandr Fedorchuk, Yaroslav Susak, Mariia Rudyk, Nataliia Senchylo, Nataliia Khranovska, Oksana Skachkova, Larysa Skivka
PURPOSE: Tumor cell resistance to platinum-based chemotherapeutic agents is one of the major hurdles to successful cancer treatment with these drugs, and is associated with alterations in tumor cell immune evasion and immunomodulatory properties. Immunocyte targeting is considered as a relevant approach to fight drug-resistant cancer. In this study, immunological hallmarks of cis-DDP-resistant Lewis lung carcinoma cells (LLC/R9) were investigated. METHODS: Immunological features of LLC/R9 cells cultured in vitro in normoxic and hypoxic conditions as well as of those that were grown in vivo were examined...
December 30, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29285236/intrapleural-targeted-therapies-anti-vegf-and-anti-egfr-in-the-model-of-malignant-pleural-effusion
#10
Milena Marques Pagliarelli Acencio, Juliana Puka, Vanessa Adélia Alvarenga, Vanessa Martins, Mariana Lombardi Peres de Carvalho, Evaldo Marchi, Vera Luiza Capelozzi, Lisete Ribeiro Teixeira
Rationale: Malignant pleural effusion has few options of treatment and drugs administrated by different routes can lead to a less permissive microenvironment for the development of malignant pleural disease. Objectives: To analyze therapies administered intrapleurally in malignant pleural disease and to study EGFR and KRAS mutations in adenocarcinoma. Methods: Mice received LLC cells and were treated intrapleurally with anti-VEGF, anti-EGFR, anti-VEGF+anti-EGFR or saline...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284782/cytotoxic-activity-of-metformin-in-vitro-does-not-correlate-with-its-antitumor-action-in-vivo
#11
O N Pyaskovskaya, D L Kolesnik, A G Fedorchuk, G V Gorbik, G I Solyanik
It is known that metformin is a hypoglycemic drug used to treat type II diabetes mellitus. Recently active studies of its antitumor activity in relation to different types of malignant cells are conducted. AIM: To determine the relationship between cytotoxic activity of metformin in vitro and its antitumor activity in vivo. MATERIALS AND METHODS: The rat C6 glioma cell line and mouse Lewis lung carcinoma cells (LLC) were used in this work. The number of living cells in the cytotoxic test was evaluated using sulforhodamine B...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29273920/particulate-matter-concentration-levels-during-intense-haze-event-in-an-urban-environment
#12
Jamiu Adetayo Adeniran, Adeniyi Saheed Aremu, Yusuf Olatunji Saadu, Rafiu Olasunkanmi Yusuf
This study assessed concentration levels of particulate matter (PM) in the ambient environment of Ilorin metropolis, Nigeria, during haze episodes. Meteorological data (wind speed and direction, rainfall data, sunshine data, relative humidity and temperature) were obtained. Aerocet 531S particle counter (MetOne Instruments, USA) was used to measure four mass concentration ranges of PM (PM1.0, PM2.5, PM10 and the total suspended particles (TSP)) in 10 locations taking into consideration land use patterns. Surfer® version 8 (Golden Software LLC, USA) was used to model the spatial variation of particulate matter concentration levels using kriging interpolation griding method...
December 22, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29242156/an-avian-reproduction-study-historical-control-database-a-tool-for-data-interpretation
#13
Pablo Valverde-Garcia, Tim Springer, Vince Kramer, Manousos Foudoulakis, James R Wheeler
Avian reproduction studies are a regulatory requirement for pesticides in many regions. The data often require careful interpretation due to the nature of the study design. Here we present the historical control dataset for bobwhite quail and mallard duck reproduction studies performed at the Evans Analytical Group LLC avian toxicology laboratory over the period 1985-2016. The analysis demonstrates the stability of reproductive parameters over time and good agreement to normal control ranges as required by the regulatory test guidelines...
December 11, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29239763/the-tourniquet-gap-a-pilot-study-of-the-intuitive-placement-of-three-tourniquet-types-by-laypersons
#14
Elliot M Ross, Julian G Mapp, Theodore T Redman, Derek J Brown, Chetan U Kharod, David A Wampler
BACKGROUND: The "Stop the Bleed" campaign in the United States advocates for nonmedical personnel to be trained in basic hemorrhage control and that "bleeding control kits" be available in high-risk areas. However, it is not clear which tourniquets are most effective in the hands of laypersons. OBJECTIVES: The objective of this pilot study was to determine which tourniquet type was the most intuitive for a layperson to apply correctly. METHODS: This project is a randomized study derived from a "Stop the Bleed" education initiative conducted between September 2016 and March 2017...
November 24, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29228576/comparison-of-tumor-biology-of-two-distinct-cell-sub-populations-in-lung-cancer-stem-cells
#15
Jianyu Wang, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Hongmei Rosie Xing
Characterization of the stem-like properties of cancer stem cells (CSCs) remain indirect and qualitative, especially the ability of CSCs to undergo asymmetric cell division for self renewal and differentiation, a unique property of cells of stem origin. It is partly due to the lack of stable cellular models of CSCs. In this study, we developed a new approach for CSC isolation and purification to derive a CSC-enriched cell line (LLC-SE). By conducting five consecutive rounds of single cell cloning using the LLC-SE cell line, we obtained two distinct sub-population of cells within the Lewis lung cancer CSCs that employed largely symmetric division for self-renewal (LLC-SD) or underwent asymmetric division for differentiation (LLC-ASD)...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29222454/stromal-versican-regulates-tumor-growth-by-promoting-angiogenesis
#16
Keiichi Asano, Courtney M Nelson, Sumeda Nandadasa, Noriko Aramaki-Hattori, Daniel J Lindner, Tyler Alban, Junko Inagaki, Takashi Ohtsuki, Toshitaka Oohashi, Suneel S Apte, Satoshi Hirohata
The proteoglycan versican is implicated in growth and metastases of several cancers. Here we investigated a potential contribution of stromal versican to tumor growth and angiogenesis. We initially determined versican expression by several cancer cell lines. Among these, MDA-MB231 and B16F10 had none to minimal expression in contrast to Lewis lung carcinoma (LLC). Notably, tumors arising from these cell lines had higher versican levels than the cell lines themselves suggesting a contribution from the host-derived tumor stroma...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208061/antichagasic-effect-of-crotalicidin-a-cathelicidin-like-vipericidin-found-in-crotalus-durissus-terrificus-rattlesnake-s-venom-gland
#17
Izabel Cristina Justino Bandeira, Danya Bandeira-Lima, Clarissa Perdigão Mello, Ticiana Praciano Pereira, Ramon Róseo Paula Pessoa Bezerra De Menezes, Tiago Lima Sampaio, Cláudio Borges Falcão, Gandhi Rádis-Baptista, Alice Maria Costa Martins
Cathelicidins are antimicrobial peptides produced by humans and animals in response to various pathogenic microbes. Crotalicidin (Ctn), a cathelicidin-related vipericidin from the South American Crotalus durissus terrificus rattlesnake's venom gland, and its fragments have demonstrated antimicrobial and antifungal activity, similarly to human cathelicidin LL-37. In order to provide templates for the development of modern trypanocidal agents, the present study evaluated the antichagasic effect of these four peptides (Ctn, Ctn[1-14], Ctn[15-34] and LL-37)...
December 6, 2017: Parasitology
https://www.readbyqxmd.com/read/29195397/howland-current-source-for-high-impedance-load-applications
#18
K F Morcelles, V G Sirtoli, P Bertemes-Filho, V C Vincence
For Electrical Impedance Spectroscopy (EIS) applications, the Enhanced Howland Current Source (EHCS) is a popular choice as an excitation circuit due to its simplicity, reliability, and safety. However, its output impedance degradation at high frequency leads to errors that are unacceptable for high load impedance applications, such as the ones which use dry or microelectrodes. Based on a proposed mathematical model, this work designed an EHCS circuit which includes an output current buffer and frequency compensation...
November 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29188773/sorafenib-tosylate-ribavirn-and-sofosbuvir-combination-therapy-for-hcv-virus-infected-patients-with-decompensated-liver-cancer
#19
Bushra Munir, Bilal Ahmed, Shumaila Kiran, Fatima Jalal, Muhammad Kashif Zahoor, Saba Shehzadi, Sadaf Oranab, Sayed Kashif Kamran, Abdul Ghaffar
Hepatitis C is the most common health problem worldwide and is major cause of death due to proliferation of hepatocellular carcinoma. The medicines available for HCV treatment overcome up-to 95% complications of HCV. However, liver cancer needs some additional care. Normally Sorafenib tosylate 200 mg is recommended for liver cancer. There is no such trial in which this drug could effectively be used in combination of direct acting antivirals for HCV. The study was conducted for HCV patients (n=30) with liver cancer having decompensated stage...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29187869/fuzi-enhances-anti-tumor-efficacy-of-radiotherapy-on-lung-cancer
#20
Qi Zhang, Xue Chen, Youjun Luo, Huaping Ren, Tiankui Qiao
In traditional Chinese medicine, Fuzi is widely used as an antitumor agent or an adjuvant medication combined with radiotherapy and chemotherapy, but its mechanism remains unclear. In this study, we investigated anti-tumor and immunoregulation efficacy of Fuzi combined with radiotherapy in mice with Lewis lung cancer (LLC). We found that Fuzi combined with radiotherapy significantly inhibited the growth of LLC, promoted the apoptosis of cancer cells, and prolonged the survival of mice with LLC. Mechanistically, we found that Fuzi decreased the proportion of Treg cells, reduced serum levels of cytokines such as interleukin (IL)-10 and transforming growth factor (TGF)-β, and downregulated the expression of programmed death ligand-1 in mice with LLC subjected to radiotherapy...
2017: Journal of Cancer
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