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https://www.readbyqxmd.com/read/28431851/ultraviolet-c-light-as-a-means-of-disinfecting-anesthesia-workstations
#1
Matthew Nottingham, Gene Peterson, Christopher Doern, Michelle Doll, Nadia Masroor, Kakotan Sanogo, Michael Stevens, Gonzalo Bearman
BACKGROUND: Anesthesia workstations (AWs) are a reservoir for pathogenic organisms potentially associated with surgical site infections. This study examined the effectiveness of the Tru-D SmartUVC device (Tru-D LLC, Nashville, TN) on bioburden reduction (BR) on AWs. METHODS: Strips of tissue inoculated with a known concentration of either Staphylococcus aureus, Enterococcus faecalis, or Acinetobacter sp were placed on 22 high-touch surfaces of an AW. Half of the AW surfaces received direct ultraviolet (UV) light exposure and half received indirect exposure...
April 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28427441/physical-activity-among-children-objective-measurements-using-fitbit-one-%C3%A2-and-actigraph
#2
Lotta Hamari, Tiina Kullberg, Jukka Ruohonen, Olli J Heinonen, Natalia Díaz-Rodríguez, Johan Lilius, Anni Pakarinen, Annukka Myllymäki, Ville Leppänen, Sanna Salanterä
BACKGROUND: Self-quantification of health parameters is becoming more popular; thus, the validity of the devices requires assessments. The aim of this study was to evaluate the validity of Fitbit One step counts (Fitbit Inc., San Francisco, CA, USA) against Actigraph wActisleep-BT step counts (ActiGraph, LLC, Pensacola, FL, USA) for measuring habitual physical activity among children. DESIGN: The study was implemented as a cross-sectional experimental design in which participants carried two waist-worn activity monitors for five consecutive days...
April 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28426569/salve-and-burdock-a-safe-effective-amish-remedy-for-treatment-of-traumatic-wounds
#3
Mitchell D Flurry, Kelsie L Herring, Logan W Carr, Randy M Hauck, John D Potochny
BACKGROUND: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28424213/magnesium-improves-cisplatin-mediated-tumor-killing-while-protecting-against-cisplatin-induced-nephrotoxicity
#4
Gopal Kumar, Malvika H Solanki, Xiangying Xue, Rachel Mintz, Swati Madankumar, Proydot K Chatterjee, Christine N Metz
Approximately 30% of all cancer patients treated with cisplatin, a widely used, broad-spectrum chemotherapeutic agent, experience acute kidney injury (AKI). Almost all patients receiving cisplatin have magnesium (Mg) losses, which are proposed to aggravate AKI. Currently, there are no methods to successfully treat or prevent cisplatin-AKI. While Mg supplementation has been shown to reduce AKI in experimental models and several small clinical trials, the effects of Mg status on tumor outcomes in immunocompetent tumor-bearing mice and humans have not been investigated...
April 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28415565/rad52-deficiency-decreases-development-of-lung-squamous-cell-carcinomas-by-enhancing-immuno-surveillance
#5
Rachel Lieberman, Jing Pan, Qi Zhang, Ming You
RAD52 is involved in homologous recombination and DNA repair. This study focuses on lung cancer progression and how the DNA repair gene, Rad52, enables tumor cells to have sufficient genome integrity, i.e., the ability to repair lethal DNA damage, to avoid cell death. In this report, we analyze the phenotypic differences between wild type and Rad52-/- in inhibition of tumor phenotypes including cell growth, viability, cytolysis, and immune profiling. We demonstrated that loss of Rad52 not only increases the death of cells undergoing carcinogen-induced transformation in vivo, but that Rad52 loss also augments in vivo antitumor activity through an enhanced capacity for direct killing of LLC tumor cells by stimulated Rad52-/- NK and CD8+ T cells...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413329/protective-effect-of-ginsenoside-rh3-against-anticancer-drug-induced-apoptosis-in-llc-pk1-kidney-cells
#6
Hye Lim Lee, Ki Sung Kang
BACKGROUND: Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22). METHODS: The present study investigated the kidney-protective effects of ginsenosides Rk2 and Rh3 against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28410172/adolescent-and-young-adult-cancer-survivorship-educational-programming-a-qualitative-evaluation
#7
Deborah Vollmer Dahlke, Kayla Fair, Yan Alicia Hong, Debra Kellstedt, Marcia G Ory
BACKGROUND: This program evaluation considers the need for increased professional and patient education for adolescent and young adult (AYA) cancer survivorship. Due to the high incidence of late effects of cancer treatment among AYA cancer survivors, knowledge sharing and communications are needed throughout the transition from cancer care into community care. AYA survivors are likely to need developmentally appropriate psychosocial care as well as extensive follow-on surveillance by physicians who are educated and aware of the likely chronic conditions and late effects that may occur in these patients...
February 10, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28409440/repair-of-primary-and-incisional-hernias-using-composite-mesh-fixed-with-absorbable-tackers-preliminary-experience-of-a-laparoscopic-approach-with-a-newly-designed-mesh-in-29-cases
#8
Ferdinando Agresta, Alice Marzetti, Silvia Vigna, Daniela Prando, Raffaele Porfidia, Salomone Di Saverio
Outcome of primary and incisional hernia repair is still affected by clinical complications in terms of recurrences, pain and discomfort. Factors like surgical approach, prosthesis characteristics and method of fixation might influence the outcome. We evaluated in a prospective observational study a cohort population which underwent primary and incisional laparoscopic hernia repair, with the use of a composite mesh in polypropylene fixed with absorbable devices. We focused on assessing the feasibility and safety of these procedures; they were always performed by an experienced laparoscopic surgeon, analyzing data from our patients through the EuraHS registry...
April 13, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28405626/basic-scholarship-in-biosafety-is-critically-needed-to-reduce-risk-of-laboratory-accidents
#9
Ryan Ritterson, Rocco Casagrande
Our firm conducted a risk/benefit assessment of "gain-of-function" research, as part of the deliberative process following a U.S. moratorium on the research (U.S. Department of Health and Human Services, U.S. Government Gain-of-Function Deliberative Process and Research Funding Pause on Selected Gain-of-Function Research Involving Influenza, MERS, and SARS Viruses, 2014). Due to significant missing but theoretically acquirable data, our biosafety assessment faced limitations, and we were forced to provide a relative, instead of absolute, measure of risk (Gryphon Scientific, LLC, Risk and Benefit Analysis of Gain of Function Research, 2016)...
March 2017: MSphere
https://www.readbyqxmd.com/read/28395722/-inhibitory-effect-and-the-mechanism-of-astragalus-polysaccharide-combined-with-cisplatin-on-growth-of-inplanted-lewis-lung-carcinoma-in-mice
#10
Mengjie Zhuang, Dan Liu, Yanwen Chen, Haixia Ming, Yang Li
Objective To observe the effect of Astragalus polysaccharides (APS) combined with cisplatin (DDP) on the expressions of cytochrome C (CytC) and high temperature required serine protease A2 (Omi/HtrA2) in the mice with Lewis lung carcinoma (LLC) transplantated tumors. Methods Ninty C57BL/6J mice were randomly divided into normal control group, model group, and (50, 100, 200) μg/mL APS groups, 6 mg/kg DDP group, 3 mg/kg DDP combined with (50, 100, 200) μg/mL APS groups. Each group included 10 mice. Except the mice in the normal group, the rest mice were inoculated subcutaneously with LLC cells (1×10(7) mL) at the right fore axillary fossa to establish tumor-bearing mouse models...
April 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28394247/erratum
#11
(no author information available yet)
In the 42(5), October 2016, issue of Journal of Oral Implantology, the article titled, "Accuracy of Dynamic Navigation for Dental Implant Placement-Model-Based Evaluation," by Robert W. Emery, Scott A. Merritt, Kathryn Lank, and Jason D. Gibbs was published with an incomplete Acknowledgment. The correct Acknowledgment statement is as follows: "This work was conducted using a grant provided by X-Nav Technologies, LLC. Robert W. Emery is the Chief Medical Officer of X-Nav Technologies, LLC, and has an equity interest in X-Nav Technologies, LLC...
April 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28386279/effect-of-rebonding-on-the-bond-strength-of-orthodontic-tubes-a-comparison-of-light-cure-adhesive-and-resin-modified-glass-ionomer-cement-in-vitro
#12
Monika Aleksiejunaite, Antanas Sidlauskas, Arunas Vasiliauskas
The purpose of this study was to determine the impact of different enamel preparation procedures and compare light cure composite (LCC) and resin-modified glass ionomer (RMGI) on the bond strength of orthodontic metal tubes rebonded to the enamel. Twenty human molars were divided into two groups (n = 10). Tubes were bonded using LCC (Transbond XT) in group 1 and RMGI (Fuji Ortho LC) in group 2. The tubes in each group were bonded following manufacturers' instructions (experiment I) and then debonded using testing machine...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28382647/helical-polyisocyanopeptides-as-lyotropic-liquid-crystals-for-measuring-residual-dipolar-couplings
#13
Xinxiang Lei, Gao-Wei Li, Jiang-Ming Cao, Wen Zong, Li Hu, Mao-Lin Hu, Ren Xiang Tan, Han Sun
Residual dipolar coupling (RDC) emerged to be an important structural parameter for organic molecules, as well as biomolecules. Here, a new helical polyisocyanopeptide (L,L-PIAF-OBn) that forms lyotropic liquid crystals (LLC) in CDCl3 is proposed as a novel weakly orienting medium for acquiring residual dipolar couplings (RDCs) of organic molecules. We demonstrate its application to the structural elucidation of triptolide and strychnine.
April 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28381520/melamine-induces-ca-2-sensing-receptor-activation-and-elicits-apoptosis-in-proximal-tubular-cells
#14
Allen J Yiu, Cliff-Lawrence Ibeh, Sanjit K Roy, Bidhan C Bandyopadhyay
Melamine causes renal tubular cell injury through inflammation, fibrosis and apoptosis. While melamine effects the rise in intracellular Ca(2+) concentration ([Ca(2+)]i), reactive oxygen species (ROS) production, and pro-apoptotic pathway activation, the mechanism of upstream Ca(2+) signaling is unknown. Since melamine has some structural similarities with L-amino acids, which endogenously activates Ca(2+)-sensing receptors (CSR), we examined the effect of melamine on CSR-induced Ca(2+) signaling and apoptotic cell death...
April 5, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28372472/in-vitro-study-of-putative-genomic-biomarkers-of-nephrotoxicity-through-differential-gene-expression-using-gentamicin
#15
Sarah Cristina Teixeira Silva, Leonardo Augusto de Almeida, Stellamaris Soares, Marina Felipe Grossi, Anete Maria Santana Valente, Carlos Alberto Tagliati
Drug-induced nephrotoxicity is one of the most frequently observed effects in long-term pharmacotherapy. The effects of nephrotoxicity are commonly discovered later due to a lack of sensitivity in in vivo methods. Therefore, researchers have tried to develop in vitro alternative methods for early identification of toxicity. In this study, LLC-PK1 cells were exposed to gentamicin through MTT and trypan blue assay. Concentrations of 4 (low), 8 (medium), and 12 (high) mM, were used to evaluate differential gene expression...
April 3, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28370575/synthesis-of-poly-%C3%AE-s-2-methylbutyl-l-glutamate-and-poly-%C3%AE-s-2-methylbutyl-d-glutamate-and-their-use-as-enantiodiscriminating-alignment-media-in-nmr-spectroscopy
#16
Stefanie Hansmann, Volker Schmidts, Christina Thiele
Lyotropic liquid crystalline (LLC) phases of polyglutamic acid derivatives, like poly-γ-benzyl-L-glutamate 1 (PBLG), are suitable alignment media for NMR spectroscopy in organic structure elucidation. Their helical structure is responsible for enantiodiscrimination. As part of our ongoing investigations concerning the alignment mechanism(s) of these systems, we were wondering, whether an additional chiral center in the side chain could improve enantiodiscrimination as compared to the helical polymer with an achiral side chain...
March 30, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28359266/identification-of-novel-class-of-triazolo-thiadiazoles-as-potent-inhibitors-of-human-heparanase-and-their-anticancer-activity
#17
C P Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J Mason, Julian E Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S Rangappa
BACKGROUND: Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics. METHODS: In the present work, we report the in vitro screening of a library of 150 small molecules with the scaffold bearing quinolones, oxazines, benzoxazines, isoxazoli(di)nes, pyrimidinones, quinolines, benzoxazines, and 4-thiazolidinones, thiadiazolo[3,2-a]pyrimidin-5-one, 1,2,4-triazolo-1,3,4-thiadiazoles, and azaspiranes against the enzymatic activity of human heparanase...
March 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28356936/danshensu-a-major-water-soluble-component-of-salvia-miltiorrhiza-enhances-the-radioresponse-for-lewis-lung-carcinoma-xenografts-in-mice
#18
Hong-Ying Cao, Rui-Lin Ding, Meng Li, Mao-Nan Yang, Ling-Lin Yang, Jing-Bo Wu, Bo Yang, Jing Wang, Cui-Lian Luo, Qing-Lian Wen
The molecule 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (danshensu), a herbal preparation used in traditional Chinese medicine, has been found to possess potential antitumor and anti-angiogenesis effects. The aim of the present study was to investigate the efficacy of the combination of radiation therapy (RT) with danshensu in the treatment of Lewis lung carcinoma (LLC) xenografts, whilst exploring and evaluating the mechanism involved. In total, 8-week old female C57BL/6J mice were randomly assigned into 3 groups to receive: RT, RT + cisplatin and RT + danshensu, respectively, when LLC reached 100-150 mm(3)...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28347581/validity-of-commercial-activity-trackers-in-children-with-congenital-heart-disease
#19
Christine Voss, Ross F Gardner, Paige H Dean, Kevin C Harris
BACKGROUND: Increasing physical activity levels is a high priority to optimize long-term health in children with congenital heart disease (CHD). Commercial activity trackers have been validated in adults and are increasingly used to measure and promote physical activity in pediatric populations, but they have not been validated in children. METHODS: In 30 children with CHD aged 10-18 years, we assessed the validity of physical activity form the wrist-based Fitbit Charge HR (Fitbit, San Francisco, CA) against hip-based ActiGraph (ActiGraph LLC, Pensacola, FL) accelerometers under free living conditions for 7 days...
December 18, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28344634/an-image-analysis-pipeline-for-automated-classification-of-imaging-light-conditions-and-for-quantification-of-wheat-canopy-cover-time-series-in-field-phenotyping
#20
Kang Yu, Norbert Kirchgessner, Christoph Grieder, Achim Walter, Andreas Hund
BACKGROUND: Robust segmentation of canopy cover (CC) from large amounts of images taken under different illumination/light conditions in the field is essential for high throughput field phenotyping (HTFP). We attempted to address this challenge by evaluating different vegetation indices and segmentation methods for analyzing images taken at varying illuminations throughout the early growth phase of wheat in the field. 40,000 images taken on 350 wheat genotypes in two consecutive years were assessed for this purpose...
2017: Plant Methods
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