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James T Harvey
Actinium-225, and its daughter bismuth-213, have great promise in alpha immuno therapy (AIT) for treatment of various disease modalities. Unfortunately, current production levels of actinium-225 that are commercially available do not support broad use of either actinium-225 or bismuth-213 in development or use for disease treatment. Further, the current cost per millicurie is much too high to be sustainable long term in the market. Resolution of both supply and cost issues allows clinical research to proceed through clinical trials and potentially produce one or more effective therapies for cancer or infectious diseases that could benefit the public...
May 15, 2018: Current Radiopharmaceuticals
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
Lin Wang, Yonggan Niu, Hui Zhang, Baokai Li
BACKGROUND: Reinforcement of lower lateral crura (LLC) is an imperative prophylaxis against the secondary deformity of alar and nasal tip in Asian rhinoplasty. The common limitation of the existing techniques is loss of nasal tip's mobility to a large degree in exchange for structural stability. In search for a natural and animated postoperative nasal tip, the elasticity and rigidity of coastal periphery was taken into account. METHOD: Two pieces of sliced costal periphery (SCP) were used to reinforce the LLC...
May 14, 2018: Journal of Craniofacial Surgery
Xin Zhao, Peipei Song, Yuhua Zhang, Jiwei Huang
Laparoscopic liver resection (LLR) has garnered attention as a new form of liver surgery. In China, many hepatobiliary surgeons are now encouraging the examination and assessment of LLC in order to improve its outcomes, and several young hepatobiliary surgeons recently shared their clinical experiences and the results of their research in presentations at the Akamon Forum as part of the 118th Annual Congress of the Japan Surgical Society, which was held April 5-7, 2018 in Tokyo, Japan. In China, LLR has gradually improved over the past 20 years, including both expanded indications and improved surgical approaches...
2018: Bioscience Trends
Yujuan Zhang, Jiamin Fu, Yanmei Shi, Shanshan Peng, Ying Cai, Xuelin Zhan, Na Song, Yanling Liu, Zhigang Wang, Yanrong Yu, Yifan Wang, Qiaofa Shi, Yingyuan Fu, Keng Yuan, Nanjin Zhou, Rakesh Joshi, Thomas E Ichim, Weiping Min
The activity of negative immune regulatory molecules, such as indoleamine 2,3-oxygenase (IDO), significantly attenuates DC (Dendritic cells)-mediated immunotherapy. We have previously reported that knockdown of IDO using siRNA can reinstall anti-tumor immunity. However, a DC-targeted siRNA delivery system for in vivo mobilized DCs remains to be developed, while gene silencing in mobilized DCs for cancer immunotherapy has never been explored. In this study, we developed a novel DC-targeted siRNA delivery system, man-GNR-siIDO, using as a nanocarrier of siRNA specific for IDO (siIDO) and mannose (man) as a guide molecule for targeting DCs...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
Adrian Baranchuk, Bryce Alexander, Debra Campbell, Sohaib Haseeb, Damian Redfearn, Chris Simpson, Ben Glover
In August 2016, Muddy Waters LLC released a short-sell report outlining potential cybersecurity vulnerabilities in several St. Jude Medical (now Abbott) pacemaker models following a demonstration of a "crash attack" and a "battery drain attack" by vulnerability research firm MedSec.1 The motivation behind the release of this report does not appear to have been focused on patient safety; rather than inform Abbott or the US Food and Drug Administration (FDA) directly, the information was released to the public sector...
May 10, 2018: Circulation
Xiaoqin Chu, Qian Li, Shuangying Gui, Zhengguang Li, Jiaojiao Cao, Jianqin Jiang
This study developed a new transdermal delivery system for the improved delivery of sinomenine hydrochloride (SH). The delivery system utilized the advantages of lyotropic liquid crystals (LLC) creating an adaptable system that offers a variety of options for the field of transdermal delivery. The formulation was prepared, characterized, and evaluated for its skin penetration in vitro. In the study, the appearance of samples was characterized by visual observation, and these LLC gels were colorless and transparent...
May 8, 2018: AAPS PharmSciTech
Bicheng Zhang, Zhimin Zhang, Jun Wang, Bo Yang, Yong Zhao, Zhiguo Rao, Jianfei Gao
Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin isolated from the traditional Chinese herb Artemisia annua , is an effective novel antimalarial agent. Studies have suggested that it also exhibits anticancer effects when administered alone or in combination with conventional chemotherapeutic agents. The present study investigated the therapeutic effect of DHA combined with carboplatin (CBP) on Lewis lung carcinoma (LLC) cells and the possible underlying molecular mechanisms. MTT and clonogenic assays demonstrated that the proliferation activity of LLC cells was inhibited in a dose-dependent manner by DHA combined with CBP...
May 2018: Oncology Letters
José Pino-Ortega, Javier García-Rubio, Sergio J Ibáñez
The aim of this study was to test the validity and reliability of the inertial device WIMU (Realtrack Systems SL, Almería, Spain) for the assessment of the vertical jump, counter movement jump (CMJ) and squat jump (SJ). Fifteen soccer players were evaluated in two identical sessions separated by one week. In each session, participants performed three jumps of each type. The flight time was quantified by the inertial device WIMU and by a force platform (Twin Plates; Globus Sport and Health Technologies LLC, Codogné, Italy) at the same time...
2018: PeerJ
Dahae Lee, Chang-Eop Kim, Sa-Yoon Park, Kem Ok Kim, Nguyen Tuan Hiep, Dongho Lee, Hyuk-Jai Jang, Jae Wook Lee, Ki Sung Kang
Preventive effects and corresponding molecular mechanisms of mugwort ( Artemisia argyi ) extract and its flavonoid constituents on contrast-induced nephrotoxicity were explored in the present study. We treated cultured LLC-PK1 cells with iodixanol to induce contrast-induced nephrotoxicity, and found that A. argyi extracts ameliorated the reduction in cellular viability following iodixanol treatment. The anti-apoptotic effect of A. argyi extracts on contrast-induced nephrotoxicity was mediated by the inhibition of mitogen-activated protein kinase (MAPK) phosphorylation and the activation of caspases...
May 7, 2018: International Journal of Molecular Sciences
Bart Depreitere, Federico Ricciardi, Mark Arts, Laurent Balabaud, Jacob M Buchowski, Cody Bunger, Chun Kee Chung, Maarten H Coppes, Michael G Fehlings, Norio Kawahara, Chong-Suh Lee, YeeLing Leung, Juan A Martin-Benlloch, Eric M Massicotte, Christian Mazel, Meyer Bernhard, Fetullah C Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro Tomita, Christian Ulbricht, Jorrit J Verlaan, Michael Wang, Alan H Crockard, David Choi
BACKGROUND: As survival following treatment for symptomatic spinal metastases increases, the incidence of local tumor recurrence may also increase. However, data regarding incidence and timing of recurrence, or duration of survival after second surgeries are not readily available, and may help to inform clinicians when to perform second surgeries. OBJECTIVE: To identify features associated with loss of local control (LLC) at a previously treated or new spinal level...
May 2, 2018: World Neurosurgery
Zhijun Jia, Ying Zhang, Qinfeng Xu, Wanhua Guo, Aibin Guo
Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negative control using Lipofectamine® 3000. Following 2 h, TGF-β1 was used to induce epithelial-to-mesenchymal transition (EMT). The protein expression levels of EMT markers: E-cadherin, fibronectin, N-cadherin and vimentin were detected by western blot analysis or immunofluorescence staining...
May 2018: Oncology Letters
Juanjuan Li, Xuan Meng, Deng Jian, Di Lu, Xin Zhang, Yanrui Chen, Jundong Zhu, Aiping Fan, Dan Ding, Deling Kong, Zheng Wang, Yanjun Zhao
Nanoparticulate anti-tumor photodynamic therapy (PDT) has been suffering from the limited dose accumulation in tumor. Herein, we report dually hypoxia- and singlet oxygen-responsive polymeric micelles to efficiently utilize the photosensitizer deposited in the disease site and hence facilely improve the therapeutic efficacy of PDT. Tailored methoxy poly(ethylene glycol)-azobenzene-poly(aspartic acid-imidazole) copolymer conjugate was synthesized. The self-assembled conjugate micelles (189 ± 19 nm) could efficiently load a model photosensitizer, chlorin e6 (Ce6) with a loading of 4...
May 3, 2018: ACS Applied Materials & Interfaces
Howard Y Li, Maria McSharry, Deandra Walker, Amber Johnson, Jeff Kwak, Bonnie Bullock, Alexander Neuwelt, Joanna M Poczobutt, Trisha R Sippel, Robert L Keith, Mary C M Weiser-Evans, Eric Clambey, Raphael A Nemenoff
Lung-specific overexpression of prostacyclin synthase (PGIS) decreases tumor initiation in murine lung cancer models. Prostacyclin analogs prevent lung tumor formation in mice and reverse bronchial dysplasia in former smokers. However, the effect of prostacyclin on lung cancer progression has not been well studied. We investigated the effects of pulmonary PGIS overexpression in an orthotopic immunocompetent mouse model of lung cancer using two murine lung cancer cell lines. Pulmonary PGIS overexpression significantly inhibited CMT167 lung tumor growth, increased CXCL9 expression, and increased CD4+ tumor-infiltrating lymphocytes...
2018: Oncoimmunology
Hiroyuki Umino, Kazuhiro Hasegawa, Hitoshi Minakuchi, Hirokazu Muraoka, Takahisa Kawaguchi, Takeshi Kanda, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
Under diabetic conditions, sodium-glucose cotransporter 2 (SGLT2) for glucose uptake in proximal tubules (PTs) increases, whereas NAD+ -dependent protein deacetylase silent mating type information regulation 2 homolog 1 (Sirtuin-1; SIRT1) for PT survival decreases. Therefore, we hypothesized that increased glucose influx by SGLT2 reduces SIRT1 expression. To test this hypothesis, db/db mice with diabetes and high-glucose (HG)-cultured porcine PT LLC-PK1 cells in a two-chamber system were treated with the SGLT2 inhibitor canagliflozin...
May 1, 2018: Scientific Reports
Denis Zofou, Fanny Fri Fombad, Narcisse V T Gandjui, Abdel Jelil Njouendou, Arnaud Jonas Kengne-Ouafo, Patrick W Chounna Ndongmo, Fabrice R Datchoua-Poutcheu, Peter A Enyong, Dizzle Tayong Bita, Mark J Taylor, Joseph D Turner, Samuel Wanji
BACKGROUND: Suitable and scalable in vitro culture conditions for parasite maintenance are needed to foster drug research for loiasis, one of the neglected tropical diseases which has attracted only limited attention over recent years, despite having important public health impacts. The present work aims to develop adequate in vitro culture systems for drug screening against both microfilariae (mf) and infective third-stage larvae (L3) of Loa loa. METHODS: In vitro culture conditions were evaluated by varying three basic culture media: Roswell Park Memorial Institute (RPMI-1640), Dulbecco's modified Eagle's medium (DMEM) and Iscove's modified Dulbecco's medium (IMDM); four sera/proteins: newborn calf serum (NCS), foetal bovine serum (FBS), bovine serum albumin (BSA) and the lipid-enriched BSA (AlbuMax® II, ALB); and co-culture with the Monkey Kidney Epithelial Cell line (LLC-MK2) as a feeder layer...
May 2, 2018: Parasites & Vectors
Arthur Caplan, Alison Bateman-House, Joanne Waldstreicher, Lisa Fedor, Ramana Sonty, Tito Roccia, Jon Ukropec, Rick Jansson
BACKGROUND: Janssen Research & Development, LLC, part of the Janssen pharmaceutical companies of Johnson & Johnson, and NYU School of Medicine partnered to establish the Compassionate Use Advisory Committee (CompAC) to evaluate the use of an independent, external, expert committee in ensuring transparent, fair, beneficent, evidence-based, and patient-focused compassionate access to investigational medicines, a public health challenge that has been an ongoing issue for over 3 decades...
January 1, 2018: Therapeutic Innovation & Regulatory Science
Giuseppe De Bernardo, Marina Riccitelli, Maurizio Giordano, Fabrizio Proietti, Desiree Sordino, Mariangela Longini, Giuseppe Buonocore, Serafina Perrone
Background: Rooming-in practice improves breastfeeding and reduces newborn stress reactivity. When this modality is not available, partial rooming-in after birth can be considered. Salivary cortisol levels (SCLs) are considered reliable biomarkers to indicate stress. Objective: To test the hypothesis that rooming-in duration impacts neonatal stress response in hospitalized newborns. Design/methods: Forty term newborns, enrolled in the Neonatology and Obstetrics Nursing, C...
2018: Mediators of Inflammation
Kleber Silva Ribeiro, Camilla Ioshida Vasconcellos, Rodrigo Pedro Soares, Maria Tays Mendes, Cameron C Ellis, Marcela Aguilera-Flores, Igor Correia de Almeida, Sergio Schenkman, Leo Kei Iwai, Ana Claudia Torrecilhas
Trypanosoma cruzi , the aetiologic agent of Chagas disease, releases vesicles containing a wide range of surface molecules known to affect the host immunological responses and the cellular infectivity. Here, we compared the secretome of two distinct strains (Y and YuYu) of T. cruzi , which were previously shown to differentially modulate host innate and acquired immune responses. Tissue culture-derived trypomastigotes of both strains secreted extracellular vesicles (EVs), as demonstrated by electron scanning microscopy...
2018: Journal of Extracellular Vesicles
Jinlong Jian, Wei Wei, Guowei Yin, Aubryanna Hettinghouse, Chuanju Liu, Yongxiang Shi
p204, a murine member of the interferon-inducible p200 protein family, and its human analogue, IFI16, have been shown to function as tumor suppressors in vitro, but the molecular events involved, in particular in vivo, remain unclear. Herein we induced the Lewis Lung carcinoma (LLC) murine model of human lung cancer in p204 null mice (KO) and their control littermates (WT). We compared the transcriptome in spleen from WT and p204 KO mice using a high-throughput RNA-sequencing array. A total 30.02 Gb of clean data were obtained, and overall Q30% was greater than 90...
April 24, 2018: Scientific Reports
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