keyword
MENU ▼
Read by QxMD icon Read
search

LLC

keyword
https://www.readbyqxmd.com/read/28541685/discovery-of-1-4-benzodiazepine-2-5-dione-bzd-derivatives-as-dual-nucleotide-binding-oligomerization-domain-containing-1-2-nod1-nod2-antagonists-sensitizing-paclitaxel-ptx-to-suppress-lewis-lung-carcinoma-llc-growth-in-vivo
#1
Suhua Wang, Jingshu Yang, Xueyuan Li, Zijie Liu, Youzhen Wu, Guangxu Si, Yiran Tao, Nan Zhao, Xiao Hu, Yao Ma, Gang Liu
Nucleotide-binding oligomerization domain-like receptors (NLRs) are intracellular sensors of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Previously, we reported nucleotide-binding oligomerization domain-containing protein 1 (NOD1) antagonists (11, 12) and a NOD2 antagonist (9) that sensitized docetaxel (DTX) or paclitaxel (PTX) treatment for breast or lung cancer. In this article, we describe for the first time a 1,4-benzodiazepine-2,5-dione (BZD) derivative (26bh) that acts as a dual NOD1/NOD2 antagonist and inhibits both nuclear factor κB (NF-κB) and mitogen-activated protein kinase (MAPK) inflammatory signaling, thereby adjuvanting PTX to suppress Lewis lung carcinoma (LLC) growth...
May 25, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28541233/quaternion-locality-constrained-coding-for-color-face-hallucination
#2
Licheng Liu, Shutao Li, C L Philip Chen
Recently, the locality linear coding (LLC) has attracted more and more attentions in the areas of image processing and computer vision. However, the conventional LLC with real setting is just designed for the grayscale image. For the color image, it usually treats each color channel individually or encodes the monochrome image by concatenating all the color channels, which ignores the correlations among different channels. In this paper, we propose a quaternion-based locality-constrained coding (QLC) model for color face hallucination in the quaternion space...
May 23, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28536426/toll-like-receptor-4-mediates-lewis-lung-carcinoma-induced-muscle-wasting-via-coordinate-activation-of-protein-degradation-pathways
#3
Guohua Zhang, Zhelong Liu, Hui Ding, Hongyu Miao, Jose M Garcia, Yi-Ping Li
Cancer-induced cachexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined etiology. Current consensus is that multiple factors contribute to cancer-induced muscle wasting, and therefore therapy requires combinational strategies. Here, we show that Toll-like receptor 4 (TLR4) mediates cancer-induced muscle wasting by directly activating muscle catabolism as well as stimulating an innate immune response in mice bearing Lewis lung carcinoma (LLC), and targeting TLR4 alone effectively abrogate muscle wasting...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28534515/stat3-activation-in-endothelial-cells-is-important-for-tumor-metastasis-via-increased-cell-adhesion-molecule-expression
#4
K-J Kim, S-H Kwon, J-H Yun, H-S Jeong, H-R Kim, E H Lee, S-K Ye, C-H Cho
Metastasis is a life-threatening feature of cancer and is primarily responsible for cancer patient mortality. Cross talk between tumor cells and endothelium is important for tumor progression and metastasis. However, very little is known about the mechanisms by which endothelial cells (ECs) that are close to tumor cells, respond to the tumor cells during tumor progression and metastasis. In this study, we exploited the use of EC-specific signal transducer activator of transcription 3 (STAT3) knockout mice to investigate the role of STAT3 in ECs in tumor progression and metastasis...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28534121/organic-anion-transporters-oat1-and-oat3-are-crucial-biopterin-transporters-involved-in-bodily-distribution-of-tetrahydrobiopterin-and-exclusion-of-its-excess
#5
Akiko Ohashi, Kaori Mamada, Tomonori Harada, Masako Naito, Tomihisa Takahashi, Shin Aizawa, Hiroyuki Hasegawa
Tetrahydrobiopterin (BH4) is a common coenzyme of phenylalanine-, tyrosine-, and tryptophan hydroxylases, alkylglycerol monooxygenase, and NO synthases (NOS). Synthetic BH4 is used medicinally for BH4-responsive phenylketonuria and inherited BH4 deficiency. BH4 supplementation has also drawn attention as a therapy for various NOS-related cardio-vascular diseases, but its use has met with limited success in decreasing BH2, the oxidized form of BH4. An increase in the BH2/BH4 ratio leads to NOS dysfunction. Previous studies revealed that BH4 supplementation caused a rapid urinary loss of BH4 accompanied by an increase in the blood BH2/BH4 ratio and an involvement of probenecid-sensitive but unknown transporters was strongly suggested in these processes...
May 22, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28530548/critical-role-of-rig-i-and-mda5-in-early-and-late-stages-of-tulane-virus-infection
#6
Preeti Chhabra, Priya Ranjan, Theresa Cromeans, Suryaprakash Sambhara, Jan Vinjé
Human noroviruses are a major cause of acute gastroenteritis worldwide, but the lack of a robust cell culture system or small animal model have hampered a better understanding of innate immunity against these viruses. Tulane virus (TV) is the prototype virus of a tentative new genus, Recovirus, in the family Caliciviridae. Its epidemiology and biological properties most closely resemble human norovirus. The host innate immune response to RNA virus infection primarily involves pathogen-sensing toll-like receptors (TLRs) TLR3 and TLR7 and retinoic acid-inducible gene I-like receptor RIG-I and melanoma differentiation associated gene 5 (MDA5)...
May 22, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28530259/approach-to-the-correction-of-drooping-tip-common-problems-and-solutions
#7
P G Giacomini, S Rubino, S Mocella, M Pascali, S Di Girolamo
The drooping tip deformity is both a bothersome aesthetic feature and functional impairment of the nose. Both static and dynamic factors may affect tip appearance and it seems logical to take into account these factors when planning correction of drooping tip. Many studies have examined this topic, but its treatment remains controversial. In order to make nasal tip surgery successful, it is useful to identify the keystone anatomical characteristics of the tip itself. Naso-labial angle, nostril axis, tip rotation angle according to Frankfort plane and columellar-facial angle may be measured to assess nasal tip position...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28516219/decreased-sensory-nerve-excitation-and-bone-pain-associated-with-mouse-lewis-lung-cancer-in-trpv1-deficient-mice
#8
Hiroki Wakabayashi, Satoshi Wakisaka, Toru Hiraga, Kenji Hata, Riko Nishimura, Makoto Tominaga, Toshiyuki Yoneda
Bone pain is one of the most common and life-limiting complications of cancer metastasis to bone. Although the mechanism of bone pain still remains poorly understood, bone pain is evoked as a consequence of sensitization and excitation of sensory nerves (SNs) innervating bone by noxious stimuli produced in the microenvironment of bone metastases. We showed that bone is innervated by calcitonin gene-related protein (CGRP)(+) SNs extending from dorsal root ganglia (DRG), the cell body of SNs, in mice. Mice intratibially injected with Lewis lung cancer (LLC) cells showed progressive bone pain evaluated by mechanical allodynia and flinching with increased CGRP(+) SNs in bone and augmented SN excitation in DRG as indicated by elevated numbers of pERK- and pCREB-immunoreactive neurons...
May 17, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28503217/assessment-and-use-of-drug-information-references-in-utah-pharmacies
#9
Krystal L Moorman, Elyse A Macdonald, Anthony Trovato, Casey R Tak
OBJECTIVE: To determine which drug references Utah pharmacists use most frequently. To determine which types of drug information questions are most commonly asked, and whether Utah pharmacists have access to adequate references to respond to these questions. METHODS: A 19-question survey was created using Qualtrics, LLC (Provo, Utah) software. An electronic survey link was sent to 1,431 pharmacists with a valid e-mail address listed in the Department of Professional Licensing database...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28501866/clinical-factors-associated-with-readmission-among-patients-with-lower-limb-cellulitis
#10
Amit Garg, Jonathan Lavian, Gloria Lin, Cristina Sison, Michael Oppenheim, Bonnie Koo
BACKGROUND: There is substantial allocation of resources directed towards evaluation and management of lower limb cellulitis (LLC) in the acute care setting. Readmission for LLC is poorly understood, and there is little evidence with which to identify patients at risk for readmission. OBJECTIVE: To describe demographics, comorbidities, admission vital signs, and laboratory markers of infection among patients with LLC who are readmitted, and to investigate which among these factors is associated with readmission...
May 13, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28487074/protective-effect-of-lanostane-triterpenoids-from-the-sclerotia-of-poria-cocos-wolf-against-cisplatin-induced-apoptosis-in-llc-pk1-cells
#11
Dahae Lee, Seulah Lee, Sang Hee Shim, Hae-Jeung Lee, Youkyung Choi, Tae Su Jang, Ki Hyun Kim, Ki Sung Kang
Cisplatin-induced nephrotoxicity is a serious adverse effect that limits the use of cisplatin in cancer patients. In the present study, we investigated the protective effect of lanostane triterpenoids (1-10) isolated from the ethanolic extract of Poria cocos Wolf against cisplatin-induced cell death in LLC-PK1 kidney tubular epithelial cells. Treatment of cisplatin induced significant cell death, which was suppressed by treatment with dehydroeburicoic acid monoacetate (1) and 3β-acetoxylanosta-7,9(11),24-trien-21-oic acid (9)...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28481828/analysis-of-interventions-required-in-12-021-children-with-acute-intoxications-admitted-to-picus
#12
Meral M Patel, Curtis D Travers, Jana A Stockwell, Robert J Geller, Pradip P Kamat, Jocelyn R Grunwell
OBJECTIVES: Acute intoxications in children account for 4.6% of annual admissions to the PICU. We aimed to describe the interventions and monitoring required for children admitted to the PICU following intoxications with the ultimate goal of determining patient and intoxication characteristics associated with the need for PICU interventions. DESIGN: Retrospective review of prospectively collected data from Virtual Pediatric Systems, LLC. SETTING: United States PICUs participating in the Virtual Pediatric Systems database from 2011 to 2014...
May 5, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28479358/involvement-of-the-transporters-p-gp-and-bcrp-in-dermal-distribution-of-the-multi-kinase-inhibitor-regorafenib-and-its-active-metabolites
#13
Ken-Ichi Fujita, Yusuke Masuo, Erina Yamazaki, Toshiki Shibutani, Yutaro Kubota, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
Regorafenib is a multi-kinase inhibitor orally administered to colorectal cancer patients, and is known to often exhibit dermal toxicity. The purpose of the present study was to clarify possible involvement of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) in the dermal accumulation of regorafenib and its active metabolites M-2 and M-5. Following intravenous administration in Abcb1a/1b/bcrp(-/-) (TKO) and wild-type (WT) mice, delayed plasma clearance of M-2 and M-5, but not regorafenib, was observed in TKO mice compared to WT mice...
May 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28476690/the-relationships-between-low-back-pain-and-lumbar-lordosis-a-systematic-review-and-meta-analysis
#14
REVIEW
Se-Woong Chun, Chai-Young Lim, Keewon Kim, Jinseub Hwang, Sun G Chung
BACKGROUND CONTEXT: Clinicians regard lumbar lordotic curvature (LLC) with respect to low back pain (LBP) in a contradictory fashion. The time-honored point of view is that LLC itself, or its increment causes LBP. On the other hand, recently, the biomechanical role of LLC has been emphasized and loss of lordosis is considered a possible cause of LBP. The relationship between LLC and LBP has immense clinical significance, since it serves as the basis of therapeutic exercises for treating and preventing LBP...
May 2, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28476089/antitumor-activity-of-alloy-and-core-shell-type-bimetallic-agau-nanoparticles
#15
Igor Shmarakov, Iuliia Mukha, Nadiia Vityuk, Vira Borschovetska, Nelya Zhyshchynska, Galyna Grodzyuk, Anna Eremenko
Nanoparticles (NPs) of noble metals, namely gold and silver, remain promising anticancer agents capable of enhancing current surgery- and chemotherapeutic-based approaches in cancer treatment. Bimetallic AgAu composition can be used as a more effective agent due to the synergetic effect. Among the physicochemical parameters affecting gold and silver nanoparticle biological activity, a primary concern relates to their size, shape, composition, charge, etc. However, the impact of metal components/composition as well as metal topological distribution within NPs is incompletely characterized and remains to be further elucidated and clarified...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28475385/preparation-of-chondroitin-sulfate-adipic-acid-dihydrazide-doxorubicin-conjugate-and-its-antitumor-characteristics-against-llc-cells
#16
Hiraku Onishi, Ai Fukasawa, Andang Miatmoko, Kumi Kawano, Yuri Ikeuchi, Yoshiyuki Hattori
Macromolecule-antitumor drug conjugates can reach tumor sites specifically via the enhanced permeability and retention (EPR) effect. It is desirable to release the drug efficiently from the conjugate at acidic pH in the tumor tissue or in the endosomes of cancer cells. In this study, we attempted to produce a carrier system with a labile chemical bond at acidic pH. Adipic acid dihydrazide (ADH)-chondroitin sulfate (CS) (termed CS-ACH) was synthesized by a two step method, with the introduction of formyl groups followed by reductive amination using ADH...
May 5, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28475071/robust-face-hallucination-via-locality-constrained-bi-layer-representation
#17
Licheng Liu, C L Philip Chen, Shutao Li, Yuan Yan Tang, Long Chen
Recently, locality-constrained linear coding (LLC) has been drawn great attentions and been widely used in image processing and computer vision tasks. However, the conventional LLC model is always fragile to outliers. In this paper, we present a robust locality-constrained bi-layer representation model to simultaneously hallucinate the face images and suppress noise and outliers with the assistant of a group of training samples. The proposed scheme is not only able to capture the nonlinear manifold structure but also robust to outliers by incorporating a weight vector into the objective function to subtly tune the contribution of each pixel offered in the objective...
May 2, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28468964/luminal-angiotensin-ii-is-internalized-as-a-complex-with-at1r-at2r-heterodimers-to-target-endoplasmic-reticulum-in-llc-pk1-cells
#18
Fernanda M Ferrão, Luiza H D Cardoso, Heather A Drummond, Xiao C Li, Jia L Zhuo, Dayene S Gomes, Lucienne S Lara, Adalberto Vieyra, Jennifer Lowe
Angiotensin II (ANG II) has many biological effects in renal physiology, particularly in Ca(2+) handling in the regulation of fluid and solute reabsorption. It involves the systemic endocrine renin-angiotensin system (RAS), but tissue and intracrine ANG II are also known. We have shown that ANG II induces heterodimerization of its AT1 and AT2 receptors (AT1R and AT2R) to stimulate sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) activity. Thus, we investigated whether ANG II-AT1R/AT2R complex is formed and internalized, and also looked at the intracellular localization of this complex to determine how its effect might be exerted on renal intracrine RAS...
May 3, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28457553/effect-of-source-of-trace-minerals-in-either-forage-or-by-product-based-diets-fed-to-dairy-cows-1-production-and-macronutrient-digestibility
#19
M J Faulkner, W P Weiss
Excess rumen-soluble Cu and Zn can alter rumen microbial populations and reduce fiber digestibility. Because of differences in particle size and chemical composition, ruminal and total-tract digestibility of fiber from forage- and by-product-based diets can differ. We hypothesized that, because of differences in mineral solubility, diets with hydroxy rather than sulfate trace minerals would have greater fiber digestibility, but the effect may depend on source of fiber. Eighteen multiparous cows were used in a split-plot replicated Latin square with two 28-d periods to evaluate the effects of Cu, Zn, and Mn source (sulfates or hydroxy; Micronutrients USA LLC, Indianapolis, IN) and neutral detergent fiber (NDF) source (forage diet = 26% NDF vs...
April 27, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28454399/inhibition-of-lung-cancer-growth-by-hangamdan-b-is-mediated-by-macrophage-activation-to-m1-subtype
#20
Hye-Rin Park, Eun-Ji Lee, Seong-Cheol Moon, Tae-Wook Chung, Keuk-Jun Kim, Hwa-Seung Yoo, Chong-Kwan Cho, Ki-Tae Ha
Re-education of tumor-associated macrophages (TAMs) toward antitumor effectors may be a promising therapeutic strategy for the successful treatment of cancer. HangAmDan-B (HAD-B), a herbal formula, has been used for stimulating immune function and activation of vital energy to cancer patients in traditional Korean Medicine. Previous studies have reported the anti-angiogenic and anti-metastatic effects of HAD-B; however, evidence on the immunomodulatory action of HAD-B was not demonstrated. In the present study, immunocompetent mice were used to demonstrate the suppression of the in vivo growth of allograft Lewis lung carcinoma (LLC) cells, by HAD-B...
April 2017: Oncology Letters
keyword
keyword
115609
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"