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https://www.readbyqxmd.com/read/28926763/synthesis-and-2d-qsar-studies-of-neolignan-based-diaryl-tetrahydrofuran-and-furan-analogues-with-remarkable-activity-against-trypanosoma-cruzi-and-assessment-of-the-trypanothione-reductase-activity
#1
Ana Paula Hartmann, Marcelo Rodrigues de Carvalho, Lilian Sibelle Campos Bernardes, Milena Hoehr de Moraes, Eduardo Borges de Melo, Carla Duque Lopes, Mario Steindel, João Santana da Silva, Ivone Carvalho
Two series of diaryl-tetrahydrofuran and -furan were synthesised and screened for anti-trypanosomal activity against trypomastigote and amastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. Based on evidence that modification of a natural product may result in a more effective drug than the natural product itself, and using known neolignan inhibitors veraguensin 1 and grandisin 2 as templates to synthesise simpler analogues, remarkable anti-trypanosomal activity and selectivity were found for 3,5-dimethoxylated diaryl-furan 5c and 2,4-dimethoxylated diaryl-tetrahydrofuran 4e analogues with EC50 0...
September 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28924214/low-frequency-magnetic-fields-induce-autophagy-associated-cell-death-in-lung-cancer-through-mir-486-mediated-inhibition-of-akt-mtor-signaling-pathway
#2
Yujun Xu, Yizhong Wang, Anran Yao, Zhen Xu, Huan Dou, Sunan Shen, Yayi Hou, Tingting Wang
Low frequency magnetic fields (LF-MFs) can affect cell proliferation in a cell-type and intensity-dependent way. Previous study has reported the anti-tumor effect of LF-MFs in lung cancers. Our previous study also optimized the intensity and duration of LF-MFs to effectively inhibit the proliferation of lung cancer cells. However, the anti-tumor mechanism of LF-MFs remains unclear, which limit the clinical application of LF-MFs in anti-tumor therapy. Here, in a well-established Lewis Lung Cancer (LLC) mouse model, we found that LF-MFs inhibit tumor growth and induce an autophagic cell death in lung cancer...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910320/differential-gene-expression-following-tlr-stimulation-in-rag1-mutant-zebrafish-tissues-and-morphological-descriptions-of-lymphocyte-like-cell-populations
#3
Preeti J Muire, Larry A Hanson, Robert Wills, Lora Petrie-Hanson
In the absence of lymphocytes, rag1-/- mutant zebrafish develop protective immunity to bacteria. In mammals, induction of protection by innate immunity can be mediated by macrophages or natural killer (NK) cells. To elucidate potential responsive cell populations, we morphologically characterized lymphocyte-like cells (LLCs) from liver, spleen and kidney hematopoietic tissues. In fish, these cells include NK cells and Non-specific cytotoxic cells (NCCs). We also evaluated the transcriptional expression response of select genes that are important indicators of NK and macrophage activation after exposure to specific TLR ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28905622/proton-diffusion-through-bilayer-pores
#4
Jesse Gatten McDaniel, Arun Yethiraj
The transport of protons through channels in complex environments is important in biology and materials science. In this work, we use multistate empirical valence bond simulations to study proton transport within a well-defined bilayer pore in a lamellar Lβ phase lyotropic liquid crystal (LLC). The LLC is formed from the self-assembly of dicarboxylate gemini surfactants in water, and a bilayer-spanning pore of ∼3-5 A radius results from the uneven partitioning of surfactants between the two leaflets of the lamella...
September 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28887274/the-qualitative-grading-of-muscle-fat-infiltration-in-whiplash-using-fat-water-magnetic-resonance-imaging
#5
Rebecca Abbott, Anneli Peolsson, Janne West, James M Elliott, Ulrika Åslund, Anette Karlsson, Olof Dahlqvist Leinhard
BACKGROUND CONTEXT: Development of muscle fat infiltration (MFI) in the neck muscles is associated with poor functional recovery following whiplash injury. Custom software and time-consuming manual segmentation of magnetic resonance (MR) images is required for quantitative analysis and presents as a barrier for clinical translation. PURPOSE: The purpose of this work was to establish a qualitative MR measure for MFI and evaluate its ability to differentiate between individuals with severe whiplash-associated disorder (WAD), mild/moderate WAD, and healthy controls...
September 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28887214/trypanocidal-activity-of-polysaccharide-extract-from-genipa-americana-leaves
#6
Racquel Oliveira da Silva Souza, Paloma Leão Sousa, Ramon Róseo Paula Pessoa Bezerra de Menezes, Tiago Lima Sampaio, Louise Donadello Tessarolo, Francisca Crislandia Oliveira Silva, Maria Gonçalves Pereira, Alice Maria Costa Martins
ETHNOPHARMACOLOGICAL RELEVANCE: The parts of the Genipa americana (Rubiaceae) tree, also known as "jenipapo" or "jenipapeiro", has been used in traditional Medicine in parasitic and bacterial infections. Thus, the experimental evolution of the antiparasitic activity of polysaccharide extracts from Genipa americana leaves, and correlation with antiparasitic and popular use is important. AIM OF THE STUDY: To evaluate the effect of polysaccharide extract obtained from Genipa americana leaves on all Trypanosoma cruzi (Y strain: benznidazole-resistant) developmental forms, a protozoan that causes Chagas' disease...
September 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28882524/activities-performed-and-treatments-conducted-prior-to-consultation-with-a-spine-surgeon-are-patients-and-clinicians-following-evidence-based-clinical-practice-guidelines
#7
Elliot I Layne, Darren M Roffey, Matthew J Coyle, Philippe Phan, Stephen P Kingwell, Eugene K Wai
BACKGROUND CONTEXT: Clinical practice guidelines (CPGs) are designed to ensure that evidence-based treatment is easily put into action. Whether patients and clinicians follow these guidelines is equivocal. PURPOSE: To examine how many patients complaining of low back pain (LBP) underwent evidence-based non-operative treatment in line with CPG recommendations prior to consultation with a spine surgeon, and to evaluate any associations between adherence to CPG recommendations and baseline factors...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28879647/evaluation-of-vitamin-d-concentration-in-a-population-of-young-healthy-women-effects-of-vitamin-d-supplementation
#8
Ewa Sewerynek, Karol Cieślak, Małgorzata Janik, Ewelina Gowin, Michał Stuss
The goal of the study was an evaluation of serum vitamin D concentrations in healthy young women. MATERIAL AND METHODS: 106 healthy women, aged 20-30 years, were included in the study. Monthly evaluation - for three months - of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women with baseline values of vit. D < 20 ng/ml (Group 1) plus the effects of 800 IU/d dose in women with the baseline value of D > 20 ng/ml (Group2). Additionally, calcium and PTH concentrations were assessed at the study onset and after a 3-month supplementation...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28876934/-rigid-luminescent-soft-materials-europium-containing-lyotropic-liquid-crystals-based-on-polyoxyethylene-phytosterols-and-ionic-liquids
#9
Sijing Yi, Jiao Wang, Zhenyu Feng, Xiao Chen
Soft materials of europium β-diketonate complexes constructed in lyotropic liquid crystals (LLCs) mediated by ionic liquids (ILs) are impressive for their excellent luminescence performance and stability. For the aim to further improve their mechanical processability and luminescent tunablility, the polyoxyethylene phytosterols (BPS-n) were introduced here as structure directing agents to prepare relatively "rigid" lamellar luminescent LLCs in 1-butyl-3-methyl-imidazolium hexafluorophosphate by doping europium β-diketonate complexes with different imidazolium counter ions...
September 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28875440/targeting-brain-tumors-by-intra-arterial-delivery-of-cell-penetrating-peptides-a-novel-approach-for-primary-and-metastatic-brain-malignancy
#10
Shailendra Joshi, Johann R N Cooke, Jason A Ellis, Charles W Emala, Jeffrey N Bruce
Computational modeling shows that intra-arterial delivery is most efficient when the delivered drugs rapidly and avidly bind to the target site. The cell-penetrating peptide trans-activator of transcription (TAT) is a candidate carrier molecule that could mediate such specificity for brain tumor chemotherapeutics. To test this hypothesis we first performed in vitro studies testing the uptake of TAT by one primary and three potentially metastatic brain cancer cell lines (9L, 4T-1, LLC, SKOV-3). Then we performed in vivo studies in a rat model where TAT was delivered either intra-arterially (IA) or intravenously (IV) to 9L brain tumors...
September 5, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28874307/prosthetic-mitral-valve-paravalvular-leak-a-problem-that-requires-dexterity
#11
James W Hansen, Gautam Gadey, Thomas C Piemonte
Prosthetic valve paravalvular leak (PVL) is a known and relatively common complication of surgical valve replacement, which may lead to significant morbidity. Patients with significant mitral valve replacement (MVR) PVL typically present with symptoms of heart failure and elevated filling pressures or with hemolytic anemia. Percutaneous closure of these leaks has become the preferred therapy. Percutaneous closure of MVR PVL can be technically challenging, given the anatomy of the approach (trans-septal, trans-apical), the level of associated comorbidities and the geographic location of the paravalvular defect...
July 24, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28870919/the-impact-of-environmental-light-intensity-on-experimental-tumor-growth
#12
Mark A Suckow, William R Wolter, Giles E Duffield
BACKGROUND/AIM: Cancer research requires for consistent models that minimize environmental variables. Within the typical laboratory animal housing facility, animals may be exposed to varying intensities of light as a result of cage type, cage position, light source, and other factors; however, studies evaluating the differential effect of light intensity during the light phase on tumor growth are lacking. MATERIALS AND METHODS: The effect of cage face light intensity, as determined by cage rack position was evaluated with two tumor models using the C57Bl/6NHsd mouse and transplantable B16F10 melanoma cells or Lewis lung carcinoma (LLC) cells...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870684/isoliquiritigenin-pretreatment-attenuates-cisplatin-induced-proximal-tubular-cells-llc-pk1-death-and-enhances-the-toxicity-induced-by-this-drug-in-bladder-cancer-t24%C3%A2-cell-line
#13
Angela Patricia Moreno-Londoño, Claudia Bello-Alvarez, José Pedraza-Chaverri
Cisplatin is an effective antineoplastic agent widely used in the treatment of solid tumors, however, it induces nephrotoxicity. Cisplatin-induced nephrotoxicity is associated with increased reactive oxygen species (ROS) production and decreased antioxidant system defense in kidney. Isoliquiritigenin (IsoLQ) is a chalcone, which is characterized by its antioxidant and antiinflammatory properties. Herein, we investigated the protective effect of IsoLQ on LLC-PK1 proximal tubular cells against cisplatin-induced death and its effect on the antineoplastic activity of cisplatin on bladder cancer T24 cell line...
September 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28866460/nitric-oxide-sensing-actuators-for-modulating-structure-in-lipid-based-liquid-crystalline-drug-delivery-systems
#14
Qingtao Liu, Jinming Hu, Michael R Whittaker, Thomas P Davis, Ben J Boyd
Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system...
August 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28853613/lung-endothelial-microrna-1-regulates-tumor-growth-and-angiogenesis
#15
Asawari Korde, Lei Jin, Jian-Ge Zhang, Anuradha Ramaswamy, Buqu Hu, Saeed Kolahian, Brenda Juan Guardela, Jose Herazo-Maya, Jill M Siegfried, Laura Stabile, Margaret A Pisani, Roy S Herbst, Naftali Kaminski, Jack A Elias, Jonathan T Puchalski, Shervin S Takyar
RATIONALE: VEGF down-regulates miR-1 in the lung endothelium, and endothelial cells play a critical role in tumor progression and angiogenesis. OBJECTIVES: To examine the clinical significance of miR-1 in NSCLC and its specific role in tumor endothelium. Method and measurements: MiR-1 levels were measured by Taqman assay. Endothelial cells were isolated by magnetic sorting. We used VE-cadherin promoter to create a vascular-specific miR-1 lentiviral vector and an inducible transgenic mouse...
August 30, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28845591/mitochondrial-degeneration-precedes-the-development-of-muscle-atrophy-in-progression-of-cancer-cachexia-in-tumour-bearing-mice
#16
Jacob L Brown, Megan E Rosa-Caldwell, David E Lee, Thomas A Blackwell, Lemuel A Brown, Richard A Perry, Wesley S Haynie, Justin P Hardee, James A Carson, Michael P Wiggs, Tyrone A Washington, Nicholas P Greene
BACKGROUND: Cancer cachexia is largely irreversible, at least via nutritional means, and responsible for 20-40% of cancer-related deaths. Therefore, preventive measures are of primary importance; however, little is known about muscle perturbations prior to onset of cachexia. Cancer cachexia is associated with mitochondrial degeneration; yet, it remains to be determined if mitochondrial degeneration precedes muscle wasting in cancer cachexia. Therefore, our purpose was to determine if mitochondrial degeneration precedes cancer-induced muscle wasting in tumour-bearing mice...
August 28, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28842662/low-tube-voltage-liver-mdct-with-sinogram-affirmed-iterative-reconstructions-for-the-detection-of-hepatocellular-carcinoma
#17
B Pregler, L P Beyer, A Teufel, C Niessen, C Stroszczynski, H Brodoefel, P Wiggermann
Aim of this study was to compare low tube voltage computed tomography (80 kV) of the liver using iterative image reconstruction (SAFIRE) with standard computed tomography (120 kV) using filtered back-projection (FBP) for the detection of hepatocellular carcinoma (HCC). 46 patients (43 men) with 93 HCC confirmed by 3 T MRI with Gd-EOB-DPTA, in inconclusive cases combined with contrast-enhanced ultrasound, underwent dual-energy CT. The raw data of the 80 kV tube was reconstructed using the iterative reconstruction algorithm SAFIRE with two strengths (I3 and I5)...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840531/long-term-effectiveness-of-adalimumab-in-patients-with-rheumatoid-arthritis-an-observational-analysis-from-the-corrona-rheumatoid-arthritis-registry
#18
Dimitrios A Pappas, Joel M Kremer, Jenny Griffith, George Reed, Bob Salim, Chitra Karki, Vishvas Garg
INTRODUCTION: Current recommendations for the management of rheumatoid arthritis (RA) focus on a treat-to-target approach with the objective of maximizing long-term health-related quality-of-life in patients with RA. Published studies from randomized clinical trials have reported limited data regarding the long-term efficacy and safety of adalimumab in patients with RA. This study aims to evaluate the long-term (10+ years) persistency and effectiveness of adalimumab in patients with RA in a real-world setting...
August 24, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28839018/complete-genome-characterization-of-the-porcine-deltacoronavirus-hkd-jpn-2016-isolated-in-japan-2016
#19
Tohru Suzuki, Jun Hayakawa, Seiichi Ohashi
In 2016, an outbreak of diarrhea with high mortality in piglets occurred on a swine farm in Hokkaido prefecture, Japan. The causative porcine deltacoronavirus HDK/JPN/2016 was isolated from intestinal samples of the dead piglets on LLC-PK1 cells. The complete genome of HKD/JPN/2016 was sequenced and analyzed by next-generation sequencing technology.
August 24, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28831751/discontinuation-of-biologic-therapy-in-rheumatoid-arthritis-analysis-from-the-corrona-ra-registry
#20
Vibeke Strand, Paul Miller, Setareh A Williams, Katherine Saunders, Shannon Grant, Joel Kremer
INTRODUCTION: Despite the availability of multiple effective therapies, discontinuation/switching of treatment is common for many patients with rheumatoid arthritis (RA). This study was designed to examine initiation of biologic disease-modifying anti-rheumatic drugs (bDMARDs) within the Consortium of Rheumatology Researchers of North America (Corrona) RA Registry, and characterize reasons for discontinuation. METHODS: Inclusion criteria were: Corrona-registered adults (≥18 years) with RA (2002-2011); age of RA onset: ≥16 years; ≥6 months' follow-up after initiation of first/subsequent bDMARD...
August 22, 2017: Rheumatology and Therapy
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