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Levosulpiride

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https://www.readbyqxmd.com/read/27866243/monitoring-of-adherence-to-headache-treatments-by-means-of-hair-analysis
#1
Anna Ferrari, Manuela Licata, Cecilia Rustichelli, Carlo Baraldi, Daniele Vandelli, Filippo Marchesi, Federica Palazzoli, Patrizia Verri, Enrico Silingardi
PURPOSE: The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeutic drugs in headache patients' hair, the degree of agreement between the self-reported drug and the drug found in hair, and whether the levels found in hair reflected the drug intake reported by the patients. METHODS: The study included 93 patients suffering from primary headaches declaring their daily intake of at least one of the following drugs during the 3 months before the hair sampling: alprazolam, amitriptyline, citalopram, clomipramine, clonazepam, delorazepam, diazepam, duloxetine, fluoxetine, flurazepam, levomepromazine, levosulpiride, lorazepam, lormetazepam, mirtazapine, paroxetine, quetiapine, sertraline, topiramate, trazodone, triazolam, venlafaxine, and zolpidem...
November 20, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27865952/a-superporous-and-superabsorbent-glucuronoxylan-hydrogel-from-quince-cydonia-oblanga-stimuli-responsive-swelling-on-off-switching-and-drug-release
#2
Muhammad Umer Ashraf, Muhammad Ajaz Hussain, Gulzar Muhammad, Muhammad Tahir Haseeb, Sajid Bashir, Syed Zajif Hussain, Irshad Hussain
Current study was designed to investigate micromeritic properties, water absorption capacity, stimuli (pH, ethanol and saline) responsive swelling-deswelling (on-off switching) and controlled drug release from the polysaccharide glucuronoxylan isolated from the seeds of Quince. The water retention capacity of Quince hydrogel (QH) was found admirable. The hydrogel also exhibited privileged swelling in water and basic buffers (pH 6.8 and 7.4) while insignificant swelling in acidic buffer (pH 1.2). The swelling kinetics of QH follows second order...
November 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27752210/a-comparative-study-of-trigger-point-therapy-with-local-anaesthetic-0-5%C3%A2-bupivacaine-versus-combined-trigger-point-injection-therapy-and-levosulpiride-in-the-management-of-myofascial-pain-syndrome-in-the-orofacial-region
#3
Pranav Gupta, Virendra Singh, Sujata Sethi, Arun Kumar
AIM: To compare the efficacy of combined local anesthetic injection with 0.5 % bupivacaine and levosulpiride versus local anesthetic injection alone on outcome measures including levels of pain intensity and depression in the management of myofascial pain syndrome in orofacial region. PATIENTS AND METHODS: This was a prospective, randomized, controlled and open-label comparative clinical study. Seventy-four patients diagnosed to have myofascial pain syndrome and fulfilling the inclusion criteria were enrolled for the study...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27599558/formulation-characterization-in-vitro-and-in-vivo-evaluation-of-castor-oil-based-self-nano-emulsifying-levosulpiride-delivery-systems
#4
G Poorani, Spandana Uppuluri, Kiran Babu Uppuluri
CONTEXT: Levosulpiride (LSP) is a hydrophobic benzamide derivative used in the treatment of schizophrenia. SNEDDS were extensively practiced for systemic delivery of poorly aqueous soluble drugs to achieve maximum bioavailability. OBJECTIVE: The present study was focussed on the formulation, optimisation and evaluation of LSP SNEDDS using castor oil, for enhancement of drug absorption and bioavailability. MATERIALS AND METHODS: Pseudo-ternary phase diagram was plotted to identify the range of SNEDDS components...
September 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27223668/efficacy-and-safety-of-levosulpiride-versus-haloperidol-injection-in-patients-with-acute-psychosis-a-randomized-double-blind-study
#5
Sagar Lavania, Samir Kumar Praharaj, Hariender Singh Bains, Vishal Sinha, Abhinav Kumar
BACKGROUND: Injectable antipsychotics are frequently required for controlling agitation and aggression in acute psychosis. No study has examined the use of injectable levosulpiride for this indication. OBJECTIVE: To compare the efficacy and safety of injectable levosulpiride and haloperidol in patients with acute psychosis. METHODS: This was a randomized, double-blind, parallel-group study in which 60 drug-naive patients having acute psychosis were randomly assigned to receive either intramuscular haloperidol (10-20 mg/d) or levosulpiride (25-50 mg/d) for 5 days...
July 2016: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27020457/dropped-head-syndrome-after-minor-trauma-in-a-patient-with-levosulpiride-aggravated-vascular-parkinsonism
#6
Soo Hyun Cho, Dokyung Lee, Tae-Beom Ahn
No abstract text is available yet for this article.
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26842870/the-effect-of-levosulpiride-on-in-vitro-motor-patterns-in-the-human-gastric-fundus-antrum-and-jejunum
#7
D Gallego, O Ortega, C Arenas, I López, E Mans, P Clavé
BACKGROUND: Levosulpiride is a 5HT4 agonist/D2 antagonist prokinetic agent used to improve gastric emptying in patients with functional dyspepsia or gastroparesis. The aim of this study was to characterize its effect on the main in vitro motility patterns in the human fundus, antrum, and jejunum. METHODS: Circular muscle strips from human stomach (antrum and fundus) and jejunum, obtained from 46 patients undergoing bariatric surgery, were studied using organ baths...
June 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/26579410/pharmacokinetics-of-levosulpiride-after-single-and-multiple-intramuscular-administrations-in-healthy-chinese-volunteers
#8
Chuting Gong, Janvier Engelbert Agbokponto, Wen Yang, Ernest Simpemba, Xiaohong Zheng, Quanying Zhang, Li Ding
The main purpose of this study was to evaluate the pharmacokinetics of levosulpiride in humans after single and multiple intramuscular injections. Six males and six females received single dose of either 25 mg or 50 mg levosulpiride, or multiple doses of 25 mg every 12 h for 5 consecutive days. In the single 25 mg study, the mean peak plasma concentration (C max) was 441 ng/mL, the mean area under the concentration-time curve from 0 to 36 h (AUC0-36) was 1724 ng h/mL, and the mean elimination half-life (t 1/2) was 7...
October 2014: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/26404395/tolerability-and-pharmacokinetic-comparison-of-oral-intramuscular-and-intravenous-administration-of-levosulpiride-after-single-and-multiple-dosing-in-healthy-chinese-volunteers
#9
RANDOMIZED CONTROLLED TRIAL
Mingzhen Xu, Ying Zhou, Yang Ni, Xiaomeng He, Huqun Li, Haseeb Sattar, Hui Chen, Weiyong Li
PURPOSE: The aim of this study was to characterize the pharmacokinetic (PK) properties and assess the safety profiles of different formulations of levosulpiride in healthy Chinese volunteers. METHODS: Levosulpiride was administered to 42 healthy male and female (1:1) subjects in tablet (PO) and injectable (IM and IV) dosage forms. Blood samples were collected at regular intervals after single and multiple drug administration. The concentration of levosulpiride in plasma was determined by a validated liquid chromatography tandem mass spectrometry method...
November 1, 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/26092223/combination-of-capillary-electrophoresis-molecular-modeling-and-nmr-to-study-the-enantioselective-complexation-of-sulpiride-with-double-cyclodextrin-systems
#10
Fabrizio Melani, Benedetta Pasquini, Claudia Caprini, Roberto Gotti, Serena Orlandini, Sandra Furlanetto
The enantioselective complexation of sulpiride by a number of cyclodextrins (CDs) was deeply investigated by different techniques with the aim of evaluating the role of the used chiral selectors involved in the enantioseparation of the eutomer levosulpiride (S-SUL) and its dextro-isomer by capillary electrophoresis (CE). A CE method was previously developed with the aim of determining the optical purity of S-SUL and was based on the use of a dual cyclodextrin system, made by sulfated-β-cyclodextrin (SβCD) and methyl-β-cyclodextrin (MβCD)...
October 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26023567/efficacy-and-tolerability-of-levosulipride-domperidone-and-metoclopramide-in-patients-with-non-ulcer-functional-dyspepsia-a-comparative-analysis
#11
Harminder Singh, Ritu Bala, Kamalpreet Kaur
OBJECTIVE: This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to November 2013. MATERIALS AND METHODS: The data collection was performed by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) question instrument for assessing the dyspeptic symptoms of functional dyspepsia in patients enrolled in the study were assessed at base line (Prior to initiation of therapy) and at the next 4 weeks on a 5-point scale...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25912592/can-nausea-and-vomiting-be-treated-with-ginger-extract
#12
REVIEW
A Giacosa, P Morazzoni, E Bombardelli, A Riva, G Bianchi Porro, M Rondanelli
Ginger (Zingiber officinale) is a spice traditionally used to treat indigestion, nausea and vomiting. Ginger extracts accelerate gastric emptying and stimulate gastric antral contractions. These effects are mainly due to the presence of gingerols and shogaols and their activity on cholinergic M receptors and serotonergic 5-HT and 5-HT receptors. Various researches on this subject have led to controversial results, due to the chemical instability of ginger extracts and particularly of gingerols, which are readily-oxidizable substances...
April 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25894107/herbal-medicine-treatment-for-drug-induced-parkinsonism
#13
Young-Ho Shim, Joo-Young Park, Won-Woo Choi, In-Kyu Min, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho, Seung-Yeon Cho
OBJECTIVES: To evaluate the role of herbal medicine in drug-induced parkinsonism (DIP) and identify an optimal treatment approach. DESIGN: Retrospective review of DIP cases treated with herbal medicine. SETTINGS/LOCATION: The Parkinson's clinic at Kyung Hee Traditional Korean Medicine Hospital, Korea. PATIENTS: Twenty-one patients whose clinical outcome and offending drug could be identified. OUTCOME MEASURES: Clinical features, treatments, and outcomes and summarized the clinical course and treatment in each case...
May 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/25582483/quality-by-design-in-the-chiral-separation-strategy-for-the-determination-of-enantiomeric-impurities-development-of-a-capillary-electrophoresis-method-based-on-dual-cyclodextrin-systems-for-the-analysis-of-levosulpiride
#14
S Orlandini, B Pasquini, M Del Bubba, S Pinzauti, S Furlanetto
Quality by design (QbD) concepts, in accordance with International Conference on Harmonisation Pharmaceutical Development guideline Q8(R2), represent an innovative strategy for the development of analytical methods. In this paper QbD principles have been comprehensively applied in the set-up of a capillary electrophoresis method aimed to quantify enantiomeric impurities. The test compound was the chiral drug substance levosulpiride (S-SUL) and the developed method was intended to be used for routine analysis of the pharmaceutical product...
February 6, 2015: Journal of Chromatography. A
https://www.readbyqxmd.com/read/25132670/the-use-of-dried-blood-spots-for-quantification-of-15-antipsychotics-and-7-metabolites-with-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#15
Lisbeth Patteet, Kristof E Maudens, Christophe P Stove, Willy E Lambert, Manuel Morrens, Bernard Sabbe, Hugo Neels
Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has consequently increased. A fast and easy to perform DBS method for quantification of 16 antipsychotics (amisulpride, aripiprazole, asenapine, bromperidol, clozapine, haloperidol, iloperidone, levosulpiride, lurasidone, olanzapine, paliperidone, pipamperone, quetiapine, risperidone, sertindole and zuclopenthixol) and 8 metabolites was developed...
June 2015: Drug Testing and Analysis
https://www.readbyqxmd.com/read/24959404/development-and-validation-of-a-uplc-method-by-the-qbd-approach-for-the-estimation-of-rabeprazole-and-levosulpiride-from-capsules
#16
Veera Raghava Raju Thummala, Raja Kumar Seshadri, Satya Sankarsana Jagan Mohan Tharlapu, Mrutyunjaya Rao Ivaturi, Someswara Rao Nittala
Statistical experimental design was used to optimize the chromatographic separations of two pharmaceutical compounds from their respective potential impurities. A fractional factorial design was utilized to study the effects of pH, organic solvent in mobile phases A&B, and flow rate on the resolution of Rabeprazole and Rabeprazole Sulfone, which had closely eluting peaks. A desirability function applied to the optimized conditions predicted the peak resolution between 2.2 and 2.7 for the Rabeprazole & Rabeprazole Sulfone impurity...
April 2014: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/24922181/levosulpiride-in-somatoform-disorders-a-double-blind-placebo-controlled-cross-over-study
#17
A C Altamura, A Di Rosa, A Ermentini, G P Guaraldi, G Invernizzi, N Rudas, G Tacchini, R Pioli
Reliable data on the psychopharmacotherapy of somatoform disorders (SDs) are scanty because of patients' poor psychopathological awareness and compliance, the need for combination treatment, and the lack of suitable instruments for clinical diagnosis and assessment. The aim of the present study was to investigate the efficacy and tolerability of low doses of levosulpiride in the treatment of SDs. Seventy-four patients with SDs diagnosed according to ICD-10 and DSM-IIIR criteria by means of the Comprehensive International Schedule for Somatoform Disorders-Somatoform Disorders Schedule (CISSD-SDS) were treated for 4 weeks either with levosulpiride (50 mg b...
2003: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/24551631/a-drug-utilization-study-of-psychotropic-drugs-prescribed-in-the-psychiatry-outpatient-department-of-a-tertiary-care-hospital
#18
Karan B Thakkar, Mangal M Jain, Gauri Billa, Abhijit Joshi, Akash A Khobragade
BACKGROUND: Psychiatric disorders are one of the major causes of morbidity. Development of newer drugs like SSRIs and atypical antipsychotics has altered the treatment paradigms. Various factors like cost of drugs, local paradigms, etc. play a role in the selection of drug therapy and hence, affect the outcome. Keeping this in mind, we conducted a study to delineate the various drugs used in psychiatric disorders, to find discrepancies, if any, between the actual and the ideal prescribing pattern of psychotropic drugs and to conduct a cost analysis...
December 2013: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/24291056/high-throughput-identification-and-quantification-of-16-antipsychotics-and-8-major-metabolites-in-serum-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#19
Lisbeth Patteet, Kristof E Maudens, Bernard Sabbe, Manuel Morrens, Mireille De Doncker, Hugo Neels
BACKGROUND: Therapeutic drug monitoring of antipsychotics is important for optimizing therapy, explaining adverse effects, non-response or poor compliance. We developed a UHPLC-MS/MS method for quantification of 16 commonly used and recently marketed antipsychotics and 8 metabolites in serum. METHODS: After liquid-liquid extraction using methyl tert-butyl ether, analysis was performed on an Agilent Technologies 1290 Infinity LC system coupled with an Agilent Technologies 6460 Triple Quadrupole MS...
February 15, 2014: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/24005344/the-relation-between-symptom-improvement-and-gastric-emptying-in-the-treatment-of-diabetic-and-idiopathic-gastroparesis
#20
REVIEW
Pieter Janssen, M Scott Harris, Mike Jones, Tatsuhiro Masaoka, Ricard Farré, Hans Törnblom, Lukas Van Oudenhove, Magnus Simrén, Jan Tack
OBJECTIVES: The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies. METHODS: The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective comparator that compared both SI and GE were included...
September 2013: American Journal of Gastroenterology
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