keyword
MENU ▼
Read by QxMD icon Read
search

Levosulpiride

keyword
https://www.readbyqxmd.com/read/29472751/levosulpiride-induced-movement-disorders
#1
Supriyo Choudhury, Koustav Chatterjee, Ravi Singh, Shantanu Shubham, Santosh Trivedi, Suparna Chatterjee, Hrishikesh Kumar
We reported a series of patients who presented with LSP-induced movement disorders specifically, dyskinetic movements. We have presented one case of LSP-induced parkinsonism and summarized ten cases of LSP-induced dyskinesia. The causality of the adverse drug reaction was assessed systematically using a validated rating system, and we extensively qualified the clinical presentation of each case of dyskinesia using a clinical rating scale. We described an unusual case of acute onset LSP-induced parkinsonism in a 56-year-aged female...
October 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29251521/development-and-characterisation-of-levosulpiride-loaded-suppositories-with-improved-bioavailability-in-vivo
#2
Fakhar Ud Din, Gul Majid Khan
The purpose of this study was to develop and characterize levosulpiride loaded liquid suppository with improved bioavailability. The content of levosulpiride-loaded liquid suppositories were optimized in a series of experiments using various weight ratios of P188, P407, Tween 80 and drug. The suppositories were liquid at room temperature, however, when rectally administered, they became gel at body temperature. Their rheological properties and release characteristics were determined in vitro while pharmacokinetic study was performed after its rectal administration in rats and compared with drug suspension...
December 18, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28880273/tailored-therapy-guided-by-multichannel-intraluminal-impedance-ph-monitoring-for-refractory-non-erosive-reflux-disease
#3
Nunzio Ranaldo, Giuseppe Losurdo, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Massimo De Carne, Enzo Ierardi, Alfredo Di Leo
A relevant percentage of non-erosive reflux disease (NERD) is refractory to proton pump inhibitors (PPIs) treatment. Multichannel intraluminal impedance pH (MII-pH) monitoring should give useful pathophysiological information about refractoriness. Therefore, our aim was to assess whether this technique could be useful to guide a 'tailored' therapy in refractory NERD. We retrospectively recruited NERD patients undergoing MII-pH monitoring for unsuccessful treatment. All patients had undergone upper endoscopy, and those with erosive esophagitis were excluded...
September 7, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28631490/pregnancy-outcomes-in-women-reporting-ingestion-of-levosulpiride-in-early-pregnancy
#4
You Jung Shin, June Seek Choi, Hyun Kyong Ahn, Hyun Mee Ryu, Moon Young Kim, Jung Yeol Han
This study aimed to evaluate pregnancy outcomes of women who were inadvertently exposed to levosulpiride in early pregnancy. All 162 consecutive singleton pregnant women counselled through the Korean Motherisk Program, Cheil General Hospital, between April 2001 and April 2014, on teratogenic risk after inadvertent exposure to levosulpiride in early pregnancy were enrolled in this study. The women were exposed to levosulpiride at median 4.8 gestational weeks. The rate of miscarriage was not significantly different between groups (9...
November 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28459037/levosulpiride-and-serum-prolactin-levels
#5
Mohammad Shafi Kuchay, Ambrish Mithal
Levosulpiride is the levorotatory enantiomer of sulpiride used in dyspeptic syndromes of various etiologies. The prokinetic effect of levosulpiride is mediated through the blockade of enteric inhibitory dopaminergic type 2 (D2) receptors. The antagonism of central D2 receptors leads to both therapeutic (e.g. antiemetic effect due to D2 receptor blockade in the chemoreceptor trigger zone) and adverse (including hyperprolactinemia) effects. Dopamine is the main endogenous inhibitor of prolactin synthesis and secretion in the anterior pituitary...
March 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28196046/bioequivalence-of-a-new-oral-levosulpiride-formulation-compared-with-a-standard-one-in-healthy-volunteers
#6
Simona De Gregori, Laura Cipollina, Annalisa De Silvestri, Marianna Ventura, Roberta Michelini, Monica Morosini, Michela Montagna, Carmine Tinelli, Mario Regazzi, Mariadelfina Molinaro, Roberto Imberti
BACKGROUND: A monocentric, single-dose, open-label, 2-way, crossover randomized study was conducted by the San Matteo Phase I Clinical Trial Unit and Experimental Therapy (Pavia, Italy) to assess the bioequivalence and the systemic tolerability of a new oral formulation of levosulpiride (tablet 25 mg: test) versus a commercially available formulation on the Italian market (tablet 25 mg: reference). METHODS: Thirty-five healthy adult volunteers, men (n = 19) and women (n = 16), aged between 18 and 55 years were screened and 32 of them were enrolled in the study...
April 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27866243/monitoring-of-adherence-to-headache-treatments-by-means-of-hair-analysis
#7
Anna Ferrari, Manuela Licata, Cecilia Rustichelli, Carlo Baraldi, Daniele Vandelli, Filippo Marchesi, Federica Palazzoli, Patrizia Verri, Enrico Silingardi
PURPOSE: The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeutic drugs in headache patients' hair, the degree of agreement between the self-reported drug and the drug found in hair, and whether the levels found in hair reflected the drug intake reported by the patients. METHODS: The study included 93 patients suffering from primary headaches declaring their daily intake of at least one of the following drugs during the 3 months before the hair sampling: alprazolam, amitriptyline, citalopram, clomipramine, clonazepam, delorazepam, diazepam, duloxetine, fluoxetine, flurazepam, levomepromazine, levosulpiride, lorazepam, lormetazepam, mirtazapine, paroxetine, quetiapine, sertraline, topiramate, trazodone, triazolam, venlafaxine, and zolpidem...
February 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27865952/a-superporous-and-superabsorbent-glucuronoxylan-hydrogel-from-quince-cydonia-oblanga-stimuli-responsive-swelling-on-off-switching-and-drug-release
#8
Muhammad Umer Ashraf, Muhammad Ajaz Hussain, Gulzar Muhammad, Muhammad Tahir Haseeb, Sajid Bashir, Syed Zajif Hussain, Irshad Hussain
Current study was designed to investigate micromeritic properties, water absorption capacity, stimuli (pH, ethanol and saline) responsive swelling-deswelling (on-off switching) and controlled drug release from the polysaccharide glucuronoxylan isolated from the seeds of Quince. The water retention capacity of Quince hydrogel (QH) was found admirable. The hydrogel also exhibited privileged swelling in water and basic buffers (pH 6.8 and 7.4) while insignificant swelling in acidic buffer (pH 1.2). The swelling kinetics of QH follows second order...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27752210/a-comparative-study-of-trigger-point-therapy-with-local-anaesthetic-0-5%C3%A2-bupivacaine-versus-combined-trigger-point-injection-therapy-and-levosulpiride-in-the-management-of-myofascial-pain-syndrome-in-the-orofacial-region
#9
Pranav Gupta, Virendra Singh, Sujata Sethi, Arun Kumar
AIM: To compare the efficacy of combined local anesthetic injection with 0.5 % bupivacaine and levosulpiride versus local anesthetic injection alone on outcome measures including levels of pain intensity and depression in the management of myofascial pain syndrome in orofacial region. PATIENTS AND METHODS: This was a prospective, randomized, controlled and open-label comparative clinical study. Seventy-four patients diagnosed to have myofascial pain syndrome and fulfilling the inclusion criteria were enrolled for the study...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27599558/formulation-characterization-in-vitro-and-in-vivo-evaluation-of-castor-oil-based-self-nano-emulsifying-levosulpiride-delivery-systems
#10
G Poorani, Spandana Uppuluri, Kiran Babu Uppuluri
CONTEXT: Levosulpiride (LSP) is a hydrophobic benzamide derivative used in the treatment of schizophrenia. SNEDDS were extensively practiced for systemic delivery of poorly aqueous soluble drugs to achieve maximum bioavailability. OBJECTIVE: The present study was focussed on the formulation, optimisation and evaluation of LSP SNEDDS using castor oil, for enhancement of drug absorption and bioavailability. MATERIALS AND METHODS: Pseudo-ternary phase diagram was plotted to identify the range of SNEDDS components...
September 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27223668/efficacy-and-safety-of-levosulpiride-versus-haloperidol-injection-in-patients-with-acute-psychosis-a-randomized-double-blind-study
#11
RANDOMIZED CONTROLLED TRIAL
Sagar Lavania, Samir Kumar Praharaj, Hariender Singh Bains, Vishal Sinha, Abhinav Kumar
BACKGROUND: Injectable antipsychotics are frequently required for controlling agitation and aggression in acute psychosis. No study has examined the use of injectable levosulpiride for this indication. OBJECTIVE: To compare the efficacy and safety of injectable levosulpiride and haloperidol in patients with acute psychosis. METHODS: This was a randomized, double-blind, parallel-group study in which 60 drug-naive patients having acute psychosis were randomly assigned to receive either intramuscular haloperidol (10-20 mg/d) or levosulpiride (25-50 mg/d) for 5 days...
July 2016: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27020457/dropped-head-syndrome-after-minor-trauma-in-a-patient-with-levosulpiride-aggravated-vascular-parkinsonism
#12
Soo Hyun Cho, Dokyung Lee, Tae-Beom Ahn
No abstract text is available yet for this article.
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26842870/the-effect-of-levosulpiride-on-in-vitro-motor-patterns-in-the-human-gastric-fundus-antrum-and-jejunum
#13
D Gallego, O Ortega, C Arenas, I López, E Mans, P Clavé
BACKGROUND: Levosulpiride is a 5HT4 agonist/D2 antagonist prokinetic agent used to improve gastric emptying in patients with functional dyspepsia or gastroparesis. The aim of this study was to characterize its effect on the main in vitro motility patterns in the human fundus, antrum, and jejunum. METHODS: Circular muscle strips from human stomach (antrum and fundus) and jejunum, obtained from 46 patients undergoing bariatric surgery, were studied using organ baths...
June 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/26579410/pharmacokinetics-of-levosulpiride-after-single-and-multiple-intramuscular-administrations-in-healthy-chinese-volunteers
#14
Chuting Gong, Janvier Engelbert Agbokponto, Wen Yang, Ernest Simpemba, Xiaohong Zheng, Quanying Zhang, Li Ding
The main purpose of this study was to evaluate the pharmacokinetics of levosulpiride in humans after single and multiple intramuscular injections. Six males and six females received single dose of either 25 mg or 50 mg levosulpiride, or multiple doses of 25 mg every 12 h for 5 consecutive days. In the single 25 mg study, the mean peak plasma concentration (C max) was 441 ng/mL, the mean area under the concentration-time curve from 0 to 36 h (AUC0-36) was 1724 ng h/mL, and the mean elimination half-life (t 1/2) was 7...
October 2014: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/26404395/tolerability-and-pharmacokinetic-comparison-of-oral-intramuscular-and-intravenous-administration-of-levosulpiride-after-single-and-multiple-dosing-in-healthy-chinese-volunteers
#15
RANDOMIZED CONTROLLED TRIAL
Mingzhen Xu, Ying Zhou, Yang Ni, Xiaomeng He, Huqun Li, Haseeb Sattar, Hui Chen, Weiyong Li
PURPOSE: The aim of this study was to characterize the pharmacokinetic (PK) properties and assess the safety profiles of different formulations of levosulpiride in healthy Chinese volunteers. METHODS: Levosulpiride was administered to 42 healthy male and female (1:1) subjects in tablet (PO) and injectable (IM and IV) dosage forms. Blood samples were collected at regular intervals after single and multiple drug administration. The concentration of levosulpiride in plasma was determined by a validated liquid chromatography tandem mass spectrometry method...
November 1, 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/26092223/combination-of-capillary-electrophoresis-molecular-modeling-and-nmr-to-study-the-enantioselective-complexation-of-sulpiride-with-double-cyclodextrin-systems
#16
Fabrizio Melani, Benedetta Pasquini, Claudia Caprini, Roberto Gotti, Serena Orlandini, Sandra Furlanetto
The enantioselective complexation of sulpiride by a number of cyclodextrins (CDs) was deeply investigated by different techniques with the aim of evaluating the role of the used chiral selectors involved in the enantioseparation of the eutomer levosulpiride (S-SUL) and its dextro-isomer by capillary electrophoresis (CE). A CE method was previously developed with the aim of determining the optical purity of S-SUL and was based on the use of a dual cyclodextrin system, made by sulfated-β-cyclodextrin (SβCD) and methyl-β-cyclodextrin (MβCD)...
October 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26023567/efficacy-and-tolerability-of-levosulipride-domperidone-and-metoclopramide-in-patients-with-non-ulcer-functional-dyspepsia-a-comparative-analysis
#17
Harminder Singh, Ritu Bala, Kamalpreet Kaur
OBJECTIVE: This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to November 2013. MATERIALS AND METHODS: The data collection was performed by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) question instrument for assessing the dyspeptic symptoms of functional dyspepsia in patients enrolled in the study were assessed at base line (Prior to initiation of therapy) and at the next 4 weeks on a 5-point scale...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25912592/can-nausea-and-vomiting-be-treated-with-ginger-extract
#18
REVIEW
A Giacosa, P Morazzoni, E Bombardelli, A Riva, G Bianchi Porro, M Rondanelli
Ginger (Zingiber officinale) is a spice traditionally used to treat indigestion, nausea and vomiting. Ginger extracts accelerate gastric emptying and stimulate gastric antral contractions. These effects are mainly due to the presence of gingerols and shogaols and their activity on cholinergic M receptors and serotonergic 5-HT and 5-HT receptors. Various researches on this subject have led to controversial results, due to the chemical instability of ginger extracts and particularly of gingerols, which are readily-oxidizable substances...
April 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25894107/herbal-medicine-treatment-for-drug-induced-parkinsonism
#19
Young-Ho Shim, Joo-Young Park, Won-Woo Choi, In-Kyu Min, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho, Seung-Yeon Cho
OBJECTIVES: To evaluate the role of herbal medicine in drug-induced parkinsonism (DIP) and identify an optimal treatment approach. DESIGN: Retrospective review of DIP cases treated with herbal medicine. SETTINGS/LOCATION: The Parkinson's clinic at Kyung Hee Traditional Korean Medicine Hospital, Korea. PATIENTS: Twenty-one patients whose clinical outcome and offending drug could be identified. OUTCOME MEASURES: Clinical features, treatments, and outcomes and summarized the clinical course and treatment in each case...
May 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/25582483/quality-by-design-in-the-chiral-separation-strategy-for-the-determination-of-enantiomeric-impurities-development-of-a-capillary-electrophoresis-method-based-on-dual-cyclodextrin-systems-for-the-analysis-of-levosulpiride
#20
S Orlandini, B Pasquini, M Del Bubba, S Pinzauti, S Furlanetto
Quality by design (QbD) concepts, in accordance with International Conference on Harmonisation Pharmaceutical Development guideline Q8(R2), represent an innovative strategy for the development of analytical methods. In this paper QbD principles have been comprehensively applied in the set-up of a capillary electrophoresis method aimed to quantify enantiomeric impurities. The test compound was the chiral drug substance levosulpiride (S-SUL) and the developed method was intended to be used for routine analysis of the pharmaceutical product...
February 6, 2015: Journal of Chromatography. A
keyword
keyword
115608
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"