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inflammatory aortitis

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https://www.readbyqxmd.com/read/28431717/chronic-periaortitis-of-ascending-aorta-with-bilateral-ostial-coronary-stenosis-in-a-young-female
#1
Gauranga Majumdar, Aditya Kapoor, Surendra K Agarwal, Navneet Srivastava, Ram Nawal Rao, Neetu Soni
An 18-year-old woman without any risk factors for coronary artery disease or systemic vasculitis and infection presented with recurrent angina at rest. Coronary angiography revealed 100% occlusion of the ostial left main coronary artery and severe ostial right coronary artery stenosis. She underwent successful coronary artery bypass graft surgery. At surgery, the external surface of the ascending aorta was covered with a soft-tissue thickened mass; histopathology of the mass revealed chronic nonspecific inflammatory aortitis...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28323232/suspected-giant-cell-aortitis-from-multiple-aortic-structural-damage-to-fatal-listeria-sepsis-a-case-report
#2
Valeria Silvestri, Giacomo Isernia
Giant cell arteritis (GCA) is an inflammatory vasculopathy affecting large- and middle-sized vessels, specifically cranial arteries derived from carotid artery. Isolated extracranial vessel involvement can occur. Interest in extravascular manifestations is recently increasing because of diffusion of sensitive and specific imaging tools such as fluorodeoxyglucose positron emission tomography computerized tomography (18 FDG PET CT). Patients have an increased relative risk of severe infection. Listeria monocytogenes infection risk is increased, and vascular system involvement and graft infection have been, although rarely, reported...
March 18, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28254396/new-insights-on-tuberculous-aortitis
#3
Laure Delaval, Tiphaine Goulenok, Paul Achouh, David Saadoun, Julien Gaudric, Quentin Pellenc, Jean-Emmanuel Kahn, Nicoletta Pasi, Damien van Gysel, Patrick Bruneval, Thomas Papo, Karim Sacre
OBJECTIVE: Aortitis is an exceedingly rare manifestation of tuberculosis. We describe 11 patients with tuberculous aortitis (TA). METHODS: Multicenter medical charts of patients hospitalized between 2003 and 2015 with TA in Paris, France, were reviewed. Demographic, medical history, laboratory, imaging, pathologic findings, treatment, and follow-up data were extracted from medical records. TA was considered when aortitis was diagnosed in a patient with active tuberculosis...
February 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28249232/prevotella-intermedia-infection-causing-acute-and-complicated-aortitis-a-case-report
#4
C Boersma, L M Kampschreur, H Buter, B M Doorenbos, P Klinkert, G G Koning
INTRODUCTION: Aortitis is a general term that refers to all conditions involving an inflammation of the aortic wall. This case report describes the surgical approach of a patient with infectious and symptomatic aortitis caused by the rare vector Prevotella intermedia. PRESENTATION OF CASE: A 44-year old male patient was admitted with fever and general discomfort after a period of sore throat in a non-teaching hospital. After two weeks he developed acute abdominal and back pain accompanied by sweating and elevated infection parameters...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28094068/-large-vessel-vasculitis-with-myelodysplastic-syndrome-a-rare-association
#5
J Galland, H Kawski, J-F Guichard, F Maurier
INTRODUCTION: The vasculitis can be the consequence of malignancy: most often hematologic rather than solid tumors. The association between large vessels vasculitis and myelodysplastic syndrome is rare. CASE REPORT: A 55-year-old man experienced asthenia, fever, polyarthritis and inflammatory syndrome. Haematological investigations found a type 2 refractory anemia with excess blasts (RAEB-2) with discovery of severe anemia (Hb: 7,8g/dl) and thrombopenia (platelets: 40,000/mm(3))...
January 13, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28064210/characteristics-of-autoantibodies-targeting-14-3-3-proteins-and-their-association-with-clinical-features-in-newly-diagnosed-giant-cell-arteritis
#6
Anne Kistner, Marc B Bigler, Kathrin Glatz, Simon B Egli, Fabian S Baldin, Florian A Marquardsen, Matthias Mehling, Katharina M Rentsch, Daniel Staub, Markus Aschwanden, Mike Recher, Thomas Daikeler, Christoph T Berger
OBJECTIVES: Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the diagnostic role and potential immunopathological involvement of anti-14-3-3 antibodies in newly diagnosed LVV patients. METHODS: Antibodies against three isoforms of 14-3-3 (γ, ε and ζ) were measured in 90 subjects: 48 GCA and 3 Takayasu's arteritis (TA) patients, and 39 controls (non-inflammatory and inflammatory diseases), using a multiplexed bead-based immunoassay and immunoprecipitation studies...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/27982548/syphilitic-aortitis-and-its-complications-in-the-modern-era
#7
Francesco Drago, Giulia Merlo, Alfredo Rebora, Aurora Parodi
INTRODUCTION: Aortitis is a well recognized manifestation of the tertiary stage of syphilis. EVIDENCE ACQUISITION: Although often regarded as an unexpected diagnosis, actually new cases of cardiovascular syphilis continue to be reported. Presumably, Treponema pallidum invades the aortic wall and the inflammatory response progresses towards obliterative endarteritis and necrosis of the muscular and elastic fibers in the aortic media. The consequent weakening of the aortic wall can lead to severe complications, represented by aortic aneurysm, aortic valvular insufficiency, aortic root dilation and coronary ostial stenosis...
December 16, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27955964/monitoring-disease-activity-in-patients-with-aortitis-and-chronic-periaortitis-undergoing-immunosuppressive-therapy-by-perfusion-ct
#8
Georg Bier, Mustafa Kurucay, Jörg Henes, Theodoros Xenitidis, Heike Preibsch, Konstantin Nikolaou, Marius Horger
RATIONALE AND OBJECTIVES: To evaluate the role of perfusion CT for monitoring inflammatory activity in patients with aortitis and chronic periaortitis undergoing immunosuppressive therapy. MATERIALS AND METHODS: Seventeen symptomatic patients (median age 68.5 years) who underwent perfusion-based computed tomography (CT) monitoring after diagnostic contrast-enhanced CT were retrospectively included in this study. Blood flow (BF), blood volume (BV), volume transfer constant (k-trans), time to peak, and mean transit time were determined by setting circular regions of interest in prominently thickened parts of the vessel wall or perfused surrounding tissue at sites where the perfusion CT color maps showed a maximum BF value...
December 9, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27696768/cd8-t-cells-contribute-to-the-development-of-coronary-arteritis-in-the-lactobacillus-casei-cell-wall-extract-induced-murine-model-of-kawasaki-disease
#9
Magali Noval Rivas, Youngho Lee, Daiko Wakita, Norika Chiba, Jargalsaikhan Dagvadorj, Kenichi Shimada, Shuang Chen, Michael C Fishbein, Thomas J A Lehman, Timothy R Crother, Moshe Arditi
OBJECTIVE: Kawasaki disease (KD) is the leading cause of acquired heart disease among children in developed countries. Coronary lesions in KD in humans are characterized by an increased presence of infiltrating CD3+ T cells; however, the specific contributions of the different T cell subpopulations in coronary arteritis development remain unknown. Therefore, we sought to investigate the function of CD4+ and CD8+ T cells, Treg cells, and natural killer (NK) T cells in the pathogenesis of KD...
February 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27630241/varicella-zoster-virus-downregulates-programmed-death-ligand-1-and-major-histocompatibility-complex-class-i-in-human-brain-vascular-adventitial-fibroblasts-perineurial-cells-and-lung-fibroblasts
#10
Dallas Jones, Anna Blackmon, C Preston Neff, Brent E Palmer, Don Gilden, Hussain Badani, Maria A Nagel
Varicella-zoster virus (VZV) vasculopathy produces stroke, giant cell arteritis, and granulomatous aortitis, and it develops after virus reactivates from ganglia and spreads transaxonally to arterial adventitia, resulting in persistent inflammation and pathological vascular remodeling. The mechanism(s) by which inflammatory cells persist in VZV-infected arteries is unknown; however, virus-induced dysregulation of programmed death ligand 1 (PD-L1) may play a role. Specifically, PD-L1 can be expressed on virtually all nucleated cells and suppresses the immune system by interacting with the programmed cell death protein receptor 1, found exclusively on immune cells; thus, downregulation of PD-L1 may promote inflammation, as seen in some autoimmune diseases...
December 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27603178/revisiting-the-role-of-environmental-and-climate-factors-on-the-epidemiology-of-kawasaki-disease
#11
Xavier Rodó, Joan Ballester, Roger Curcoll, Joseph Boyard-Micheau, Sílvia Borràs, Josep-Anton Morguí
Can environmental factors, such as air-transported preformed toxins, be of key relevance to the health outcomes of poorly understood human ailments (e.g., rheumatic diseases such as vasculitides, some inflammatory diseases, or even severe childhood acquired heart diseases)? Can the physical, chemical, or biological features of air masses be linked to the emergence of diseases such as Kawasaki disease (KD), Henoch-Schönlein purpura, Takayasu's aortitis, and ANCA-associated vasculitis? These diseases surprisingly share some common epidemiological features...
October 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27546993/inflammatory-diseases-of-the-aorta-part-2-infectious-aortitis
#12
I Töpel, N Zorger, M Steinbauer
Infectious aortitis is a rare but life-threatening disease. Due to impending local and systemic complications, prompt diagnosis and initiation of effective causal treatment are essential for patient survival. Differentiating infectious aortitis from other aortic diseases, in particular non-infectious aortitis, is of great importance. This article discusses the various causes, diagnostic tools, and therapeutic strategies for infectious aortitis.
2016: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/27546992/inflammatory-diseases-of-the-aorta-part-1-non-infectious-aortitis
#13
REVIEW
I Töpel, N Zorger, M Steinbauer
Aortitis is a term which encompasses inflammatory changes to the aortic wall from various pathogenic etiologies. Large vessel vasculitis, such as Takayasu arteritis and giant cell arteritis represent the most common entities; however, there is also an association with other rheumatological diseases. Chronic idiopathic periaortitis represents a distinct disease entity and infectious aortitis is a rare but life-threatening disease. Due to the diverse clinical pictures vascular surgeons often face a significant challenge in terms of making an accurate initial diagnosis...
2016: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/27526100/vascular-diseases-aortitis-aortic-aneurysms-and-vascular-calcification
#14
REVIEW
Elena Ladich, Kazuyuki Yahagi, Maria E Romero, Renu Virmani
Inflammatory diseases of the aorta broadly include noninfectious and infectious aortitis, periaortitis, atherosclerosis, and inflammatory atherosclerotic aneurysms. Aortitis is uncommon but is increasingly recognized as an important cause of aortic aneurysms and dissections. Abdominal (AAA) and thoracic aortic aneurysms (TAA) have different pathologies and etiologies. AAAs are the most common type of aortic aneurysm, and the vast majority of these are atherosclerotic. The causes of TAA vary depending on the site of involvement, but medial degeneration is a common pathologic substrate, regardless of etiology, and genetic influences play a prominent role in TAA expression...
September 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27428181/large-vessel-involvement-by-igg4-related-disease
#15
Cory A Perugino, Zachary S Wallace, Nandini Meyersohn, George Oliveira, James R Stone, John H Stone
OBJECTIVES: IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs and lead to tumefactive, tissue-destructive lesions. Reports have described inflammatory aortitis and periaortitis, the latter in the setting of retroperitoneal fibrosis (RPF), but have not distinguished adequately between these 2 manifestations. The frequency, radiologic features, and response of vascular complications to B cell depletion remain poorly defined...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27319272/-peripheral-artery-disease-in-patients-younger-than-50%C3%A2-years-old-which-etiology
#16
REVIEW
S Cotard, A Nouni, V Jaquinandi, G Gladu, A Kaladji, G Mahé
Peripheral arterial disease (PAD) encompasses disease of all arteries of the body except the coronary arteries. The main etiology whatever the patient's age is atherosclerosis. Different etiologies can induce PAD especially when patients are younger than 50 years old and have no cardiovascular risk factors (smoking, hypertension, diabetes…). PAD that appears before 50 years old can be named juvenile PAD (JPAD) although there is no consensus about the definition. The aim of this work is to present the different etiologies of JPAD according to their hereditary, acquired or mixed origins...
September 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27241076/-giant-cell-aortitis-complicated-by-aa-amyloidosis-diagnosed-with-imaging-techniques-report-of-a-case
#17
J-P Hammelin, G Cardon, M Reberolle, F Moulonguet, Y Neugebauer, G Raybaud, V Gnemmi, E Hachulla
INTRODUCTION: AA amyloidosis is a common but severe complication of many chronic inflammatory processes of infectious, autoimmune, or neoplastic origin. It frequently leads to renal damage, often presenting as a nephrotic syndrome. Giant cell arteritis is a common inflammatory arteritis in elderly people, but rarely complicated by AA amyloidosis. CASE REPORT: We report an 87-year-old female who presented with a nephrotic syndrome and a chronic inflammation, in whom the kidney biopsy showed secondary amyloidosis...
May 27, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27222669/cardiac-involvement-in-ankylosing-spondylitis
#18
REVIEW
Yasemin Ozkan
Ankylosing spondylitis is one of the subgroup of diseases called "seronegative spondyloarthropathy". Frequently, it affects the vertebral colon and sacroiliac joint primarily and affects the peripheral joints less often. This chronic, inflammatory and rheumatic disease can also affect the extraarticular regions of the body. The extraarticular affections can be ophthalmologic, cardiac, pulmonary or neurologic. The cardiac affection can be 2-10% in all patients. Cardiac complications such as left ventricular dysfunction, aortitis, aortic regurgitation, pericarditis and cardiomegaly are reviewed...
June 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27219304/predictors-of-dissection-in-aortic-aneurysms-from-giant-cell-arteritis
#19
Tanaz A Kermani, Kenneth J Warrington, Cynthia S Crowson, Gene G Hunder, Steven R Ytterberg, Sherine E Gabriel, Eric L Matteson
BACKGROUND: Factors associated with dissection from inflammatory aortic aneurysms may be different from those in the general population. OBJECTIVE: The aim of this study was to evaluate the risk factors for aortic dissection/rupture in patients with giant cell arteritis (GCA) and aortic aneurysms. METHODS: A population-based incident cohort of patients with a diagnosis of GCA from 1950 to 2004 was used. All patients with aortic aneurysms diagnosed 1 year prior to GCA diagnosis or any time thereafter were included...
June 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27148833/clinical-impact-of-telemedicine-network-system-at-rural-hospitals-without-on-site-cardiac-surgery-backup
#20
Yasuhiro Nagayoshi, Shuichi Oshima, Hisao Ogawa
BACKGROUND: In Japan, catheterization laboratories are available in each medical service area. However, cardiovascular centers capable of surgical procedures are concentrated in urban areas. Critically ill patients with complex coronary lesions must be transferred to receive advanced medical care. Interhospital conferencing is necessary for an optimal patient transfer. We investigated the benefit and utility of a Digital Imaging and Communications in Medicine (DICOM) telemedicine network at a rural hospital without on-site cardiac surgery backup in Japan...
May 5, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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