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Lactobacillus reuteri RC-14

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https://www.readbyqxmd.com/read/27590374/oral-lactobacillus-rhamnosus-gr-1-and-lactobacillus-reuteri-rc-14-to-reduce-group-b-streptococcus-colonization-in-pregnant-women-a%C3%A2-randomized-controlled-trial
#1
Ming Ho, Yin-Yi Chang, Wei-Chun Chang, Hung-Chih Lin, Mei-Hung Wang, Wu-Chou Lin, Tsan-Hung Chiu
OBJECTIVE: This study is to examine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 taken orally before bedtime on Group B Streptococcus (GBS)-positive pregnant women with respect to becoming GBS negative. MATERIALS AND METHODS: In total, 110 pregnant women at 35-37 weeks of gestation who were diagnosed by GBS culture as being GBS positive for both vaginal and rectal GBS colonization were randomly assigned to be orally treated with two placebo capsules or two probiotic capsules (containing L...
August 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27442847/supplementation-with-fruit-and-okara-soybean-by-products-and-amaranth-flour-increases-the-folate-production-by-starter-and-probiotic-cultures
#2
Marcela Albuquerque Cavalcanti de Albuquerque, Raquel Bedani, Antônio Diogo Silva Vieira, Jean Guy LeBlanc, Susana Marta Isay Saad
The ability of two starter cultures (Streptococcus (S.) thermophilus ST-M6 and St. thermophilus TA-40) and eleven probiotic cultures (St. thermophilus TH-4, Lactobacillus (Lb.) acidophilus LA-5, Lb. fermentum PCC, Lb. reuteri RC-14, Lb. paracasei subsp. paracasei, Lb. casei 431, Lb. paracasei subsp. paracasei F19, Lb. rhamnosus GR-1, and Lb. rhamnosus LGG, Bifidobacterium (B.) animalis subsp. lactis BB-12, B. longum subsp. longum BB-46, and B. longum subsp. infantis BB-02) to produce folate in a modified MRS broth (mMRS) supplemented with different fruit (passion fruit, acerola, orange, and mango) and okara soybean by-products and amaranth flour was investigated...
November 7, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27342046/effect-of-probiotics-on-vaginal-health-in-pregnancy-effpro-a-randomized-controlled-trial
#3
Christian Gille, Bettina Böer, Matthias Marschal, Michael S Urschitz, Volker Heinecke, Verena Hund, Sarah Speidel, Inge Tarnow, Ioannis Mylonas, Axel Franz, Corinna Engel, Christian F Poets
BACKGROUND: Preterm delivery is a leading cause of neonatal morbidity and mortality. It often results from chorioamnionitis, a complication of bacterial vaginosis. Probiotics are effective in treating bacterial vaginosis in non-pregnant women, studies in pregnant woman are missing. OBJECTIVE: To evaluate whether an oral probiotic food supplement supports the maintenance or restoration of a normal vaginal microbiota during pregnancy. STUDY DESIGN: Randomized, placebo-controlled, triple-blind, parallel group trial...
June 21, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27092529/non-antibiotic-prophylaxis-for-urinary-tract-infections
#4
REVIEW
Mariëlle Beerepoot, Suzanne Geerlings
Increasing antimicrobial resistance has stimulated interest in non-antibiotic prophylaxis of recurrent urinary tract infections (UTIs). Well-known steps in the pathogenesis of UTIs are urogenital colonization and adherence of uropathogens to uroepithelial cell receptors. To prevent colonization in postmenopausal women, vaginal, but not oral, estrogens have been shown to restore the vagina lactobacilli flora, reduce vaginal colonization with Enterobacteriaceae, and reduce the number of UTIs compared to placebo...
2016: Pathogens
https://www.readbyqxmd.com/read/27084704/probiotics-lgg-bb12-or-rc14-gr1-versus-placebo-as-prophylaxis-for-urinary-tract-infection-in-persons-with-spinal-cord-injury-prosciuttu-a-study-protocol-for-a-randomised-controlled-trial
#5
Bonsan Bonne Lee, Swee-Ling Toh, Suzanne Ryan, Judy M Simpson, Kate Clezy, Laetitia Bossa, Scott A Rice, Obaydullah Marial, Gerard Weber, Jasbeer Kaur, Claire Boswell-Ruys, Stephen Goodall, James Middleton, Mark Tudehope, George Kotsiou
BACKGROUND: Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant. Among the SCI population, there is a high rate of multi-resistant organism [MRO] colonisation. Non-antibiotic prevention strategies are needed to prevent UTI without increasing resistance. Probiotics have been reported to be beneficial in preventing UTIs in post-menopausal women in several in vivo and in vitro studies...
2016: BMC Urology
https://www.readbyqxmd.com/read/26282697/changes-in-vaginal-microbiota-following-antimicrobial-and-probiotic-therapy
#6
Jean M Macklaim, Jose C Clemente, Rob Knight, Gregory B Gloor, Gregor Reid
BACKGROUND: The composition of the vaginal microbiota is known to be important for health. When infections occur, antimicrobial therapy is often poorly efficacious. OBJECTIVE AND DESIGN: We used 16S rRNA gene sequencing to characterize changes in the bacterial microbiota following oral antimicrobial and probiotic interventions. RESULTS: While the bacterial vaginal profiles of women with vulvovaginal candidiasis were dominated by lactobacilli as in healthy women, and unchanged by therapy, Gardnerella vaginalis, Prevotella, Atopobium, Sneathia, and Megasphaera dominated the vagina of women with bacterial vaginosis (BV), and treatment with tinidazole plus Lactobacillus reuteri RC-14+L...
2015: Microbial Ecology in Health and Disease
https://www.readbyqxmd.com/read/26028405/in-vitro-modulation-of-probiotic-bacteria-on-the-biofilm-of-candida-glabrata
#7
Shu Yih Chew, Yoke Kqueen Cheah, Heng Fong Seow, Doblin Sandai, Leslie Thian Lung Than
A conspicuous new concept of pathogens living as the microbial societies in the human host rather than free planktonic cells has raised considerable concerns among scientists and clinicians. Fungal biofilms are communities of cells that possess distinct characteristic such as increased resistance to the immune defence and antimycotic agents in comparison to their planktonic cells counterpart. Therefore, inhibition of the biofilm may represent a new paradigm for antifungal development. In this study, we aim to evaluate the in vitro modulation of vulvovaginal candidiasis (VVC)-causing Candida glabrata biofilms using probiotic lactobacilli strains...
August 2015: Anaerobe
https://www.readbyqxmd.com/read/25688886/probiotic-lactobacillus-rhamnosus-gr-1-and-lactobacillus-reuteri-rc-14-exhibit-strong-antifungal-effects-against-vulvovaginal-candidiasis-causing-candida-glabrata-isolates
#8
S Y Chew, Y K Cheah, H F Seow, D Sandai, L T L Than
AIMS: This study investigates the antagonistic effects of the probiotic strains Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 against vulvovaginal candidiasis (VVC)-causing Candida glabrata. METHODS AND RESULTS: Growth inhibitory activities of Lact. rhamnosus GR-1 and Lact. reuteri RC-14 strains against C. glabrata were demonstrated using a spot overlay assay and a plate-based microtitre assay. In addition, these probiotic lactobacilli strains also exhibited potent candidacidal activity against C...
May 2015: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/25127240/a-systems-biology-approach-investigating-the-effect-of-probiotics-on-the-vaginal-microbiome-and-host-responses-in-a-double-blind-placebo-controlled-clinical-trial-of-post-menopausal-women
#9
Jordan E Bisanz, Shannon Seney, Amy McMillan, Rebecca Vongsa, David Koenig, LungFai Wong, Barbara Dvoracek, Gregory B Gloor, Mark Sumarah, Brenda Ford, Dorli Herman, Jeremy P Burton, Gregor Reid
UNLABELLED: A lactobacilli dominated microbiota in most pre and post-menopausal women is an indicator of vaginal health. The objective of this double blinded, placebo-controlled crossover study was to evaluate in 14 post-menopausal women with an intermediate Nugent score, the effect of 3 days of vaginal administration of probiotic L. rhamnosus GR-1 and L. reuteri RC-14 (2.5×109 CFU each) on the microbiota and host response. The probiotic treatment did not result in an improved Nugent score when compared to when placebo...
2014: PloS One
https://www.readbyqxmd.com/read/23395559/efficacy-of-orally-applied-probiotic-capsules-for-bacterial-vaginosis-and-other-vaginal-infections-a-double-blind-randomized-placebo-controlled-study
#10
RANDOMIZED CONTROLLED TRIAL
Goran Vujic, Alenka Jajac Knez, Vedrana Despot Stefanovic, Vedrana Kuzmic Vrbanovic
OBJECTIVE: To assess the efficacy of orally administered capsules containing the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 (Lactogyn, JGL, Rijeka, Croatia) compared to placebo in otherwise healthy women diagnosed with bacterial vaginosis. STUDY DESIGN: Randomized, double-blind, multicentric, placebo-controlled trial, including a total of 544 subjects. Included were women older than 18 years of age, diagnosed with vaginal infection. Subjects received either probiotic (395 subjects or 72...
May 2013: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/22811591/probiotic-interference-of-lactobacillus-rhamnosus-gr-1-and-lactobacillus-reuteri-rc-14-with-the-opportunistic-fungal-pathogen-candida-albicans
#11
Gerwald A Köhler, Senait Assefa, Gregor Reid
Candida albicans is the most important Candida species causing vulvovaginal candidiasis (VVC). VVC has significant medical and economical impact on women's health and wellbeing. While current antifungal treatment is reasonably effective, supportive and preventive measures such as application of probiotics are required to reduce the incidence of VVC. We investigated the potential of the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 towards control of C. albicans. In vitro experiments demonstrated that lactic acid at low pH plays a major role in suppressing fungal growth...
2012: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/22782199/lactobacilli-vs-antibiotics-to-prevent-urinary-tract-infections-a-randomized-double-blind-noninferiority-trial-in-postmenopausal-women
#12
RANDOMIZED CONTROLLED TRIAL
Mariëlle A J Beerepoot, Gerben ter Riet, Sita Nys, Willem M van der Wal, Corianne A J M de Borgie, Theo M de Reijke, Jan M Prins, Jeanne Koeijers, Annelies Verbon, Ellen Stobberingh, Suzanne E Geerlings
BACKGROUND: Growing antibiotic resistance warrants studying nonantibiotic prophylaxis for recurrent urinary tract infections (UTIs). Use of lactobacilli appears to be promising. METHODS: Between January 2005 and August 2007, we randomized 252 postmenopausal women with recurrent UTIs taking part in a double-blind noninferiority trial to receive 12 months of prophylaxis with trimethoprim-sulfamethoxazole, 480 mg, once daily or oral capsules containing 109 colony-forming units of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 twice daily...
May 14, 2012: Archives of Internal Medicine
https://www.readbyqxmd.com/read/22715972/probiotic-lactobacillus-and-estrogen-effects-on-vaginal-epithelial-gene-expression-responses-to-candida-albicans
#13
R Doug Wagner, Shemedia J Johnson
BACKGROUND: Vaginal epithelial cells have receptors, signal transduction mechanisms, and cytokine secretion capabilities to recruit host defenses against Candida albicans infections. This research evaluates how probiotic lactobacilli affect the defensive epithelial response. METHODS: This study used quantitative reverse transcription-polymerase chain reaction assay (qRT-PCR), flow cytometry, and a multiplex immunoassay to observe changes in the regulation of gene expression related to cytokine responses in the VK2 (E6/E7) vaginal epithelial cell line treated with 17β-estradiol, exposed to probiotic Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14® and challenged with C...
2012: Journal of Biomedical Science
https://www.readbyqxmd.com/read/22629342/adhesion-forces-and-coaggregation-between-vaginal-staphylococci-and-lactobacilli
#14
Jessica A Younes, Henny C van der Mei, Edwin van den Heuvel, Henk J Busscher, Gregor Reid
Urogenital infections are the most common ailments afflicting women. They are treated with dated antimicrobials whose efficacy is diminishing. The process of infection involves pathogen adhesion and displacement of indigenous Lactobacillus crispatus and Lactobacillus jensenii. An alternative therapeutic approach to antimicrobial therapy is to reestablish lactobacilli in this microbiome through probiotic administration. We hypothesized that lactobacilli displaying strong adhesion forces with pathogens would facilitate coaggregation between the two strains, ultimately explaining the elimination of pathogens seen in vivo...
2012: PloS One
https://www.readbyqxmd.com/read/22191313/the-influence-of-probiotics-on-the-cervical-malignancy-diagnostics-quality
#15
Zivko Perisić, Natasa Perisić, Svetlana Golocorbin Kon, Dusan Vesović, Ana Mitrović Jovanović, Momir Mikov
BACKGROUND/AIM: Probiotics help to provide an optimum balance in the intestines. Probiotics species competitive block toxic substances and growth of unwanted bacteria and yeast species while they compete for the space and food. Lactogyn is the first oral probiotics on Serbian market dedicated to maintaining a normal vaginal flora. Lactogyn contains two well studied probiotics strains - Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Both of them are considered as probiotic agents with therapeutic properties increase the population of beneficial lactobacillus organisms within the vagina...
November 2011: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/21637031/effect-of-25-weeks-probiotic-supplementation-on-immune-function-of-hiv-patients
#16
RANDOMIZED CONTROLLED TRIAL
Ruben Hummelen, John Changalucha, Nicodemus L Butamanya, Tara E Koyama, Adrian Cook, J Dik F Habbema, Gregor Reid
INTRODUCTION: Studies with a follow-up of < 8 weeks have indicated immune-preserving effects of yogurt probiotic supplementation among HIV patients. To evaluate the impact of 25 weeks use of probiotics, a randomized, double blind, controlled study was undertaken on 65 women who were naïve to anti-retroviral treatment. RESULTS: Ten participants were excluded post-randomization due to non-eligibility. Thirty participants were assigned placebo, of whom 25 completed the study versus 19 of 25 completing the study in the probiotics group (p = 0...
March 2011: Gut Microbes
https://www.readbyqxmd.com/read/21629190/a-randomized-double-blinded-placebo-controlled-pilot-study-of-probiotics-in-active-rheumatoid-arthritis
#17
RANDOMIZED CONTROLLED TRIAL
Maria de Los Angeles Pineda, Sarah Frances Thompson, Kelly Summers, Faye de Leon, Janet Pope, Gregor Reid
BACKGROUND: To examine the effect of probiotics as adjunctive therapy for the treatment of rheumatoid arthritis (RA). A sample size of 30 subjects was calculated to determine a moderate effect. MATERIAL/METHODS: A three month double-blind, placebo-controlled study was performed using probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 capsules administered orally. Inclusion criteria required at least 4 swollen and 4 tender joints and stable medications with no steroids for at least 1 month prior to and during the study...
June 2011: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/21282650/lactobacillus-reuteri-produced-cyclic-dipeptides-quench-agr-mediated-expression-of-toxic-shock-syndrome-toxin-1-in-staphylococci
#18
Jingru Li, Wenliang Wang, Stacey X Xu, Nathan A Magarvey, John K McCormick
The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of menstruation-associated toxic shock syndrome (TSS). In this work, we show that the human vaginal isolate Lactobacillus reuteri RC-14 produces small signaling molecules that are able to interfere with the staphylococcal quorum-sensing system agr, a key regulator of virulence genes, and repress the expression of TSST-1 in S. aureus MN8, a prototype of menstrual TSS S...
February 22, 2011: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/20801446/lactobacillus-rhamnosus-gr-1-and-l-reuteri-rc-14-to-prevent-or-cure-bacterial-vaginosis-among-women-with-hiv
#19
RANDOMIZED CONTROLLED TRIAL
Ruben Hummelen, John Changalucha, Nicodemus L Butamanya, Adrian Cook, J Dik F Habbema, Gregor Reid
OBJECTIVE: To assess, among women with HIV, whether long-term oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 supplementation can prevent bacterial vaginosis (BV) and enhance the cure rate of metronidazole among those with BV. METHODS: A randomized, double-blind, placebo-controlled trial conducted among 65 HIV-infected women with an aberrant microbiota (Nugent score 4-10) who were randomized to receive daily probiotics or placebo for 6 months. Those with BV (Nugent score 7-10) additionally received metronidazole for 10 days (400 mg twice daily)...
December 2010: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/20591191/randomized-controlled-trial-of-probiotics-for-the-prevention-of-spontaneous-preterm-delivery-associated-with-intrauterine-infection-study-protocol
#20
Leticia Krauss-Silva, Maria Elizabeth L Moreira, Mariane B Alves, Maria R Rezende, Alcione Braga, Karla G Camacho, Maria Rosa R Batista, Clarisse Savastano, Antonio Almada-Horta, Fernando Guerra
BACKGROUND: Spontaneous preterm deliveries that occur before the 34th week of gestation, and particularly before the 32nd week of gestation, have been strongly associated to intrauterine infection, ascending from vagina, and represent the largest portion of neonatal deaths and neurological problems. Bacterial vaginosis, characterized by a diminished or absent flora of lactobacilli and increased colonization of several anaerobic or facultative microorganisms, increases two times the risk of preterm delivery before the 34th week...
2010: Reproductive Health
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