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https://www.readbyqxmd.com/read/29786973/amniotic-fluid-lactic-acid-and-matrix-metalloproteinase-8-levels-at-the-time-of-fetal-surgery-for-a-spine-defect-association-with-subsequent-premature-preterm-rupture-of-membranes
#1
Antonio F Moron, Aikaterini Athanasiou, Mauricio Barbosa, Herbene J Milani, Stephanno G Sarmento, Sergio Cavalheiro, Steven S Witkin
OBJECTIVE: In utero fetal surgery to correct incomplete closure of the spinal cord lessens the extent of permanent damage but is associated with preterm premature rupture of membranes (pPROM). We determined if compounds in amniotic fluid (AF) collected at the time of surgery predicted subsequent development of pPROM. DESIGN: Prospective study. SETTING: Hospitals in Sao Paulo, Brazil. POPULATION: Twenty four consecutive pregnant women at 24-26 weeks gestation seen between February and October 2017 with a singleton pregnancy underwent in utero surgery to correct an open spinal defect in their fetus...
May 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29786952/arabidopsis-sumo-protease-asp1-positively-regulates-aba-signaling-during-early-seedling-development
#2
Qiongli Wang, Gao-Ping Qu, Xiangxiong Kong, Yan Yan, Jigang Li, Jing Bo Jin
The small ubiquitin-related modifier (SUMO) modification plays an important role in the regulation of abscisic acid (ABA) signaling, but the function of the SUMO protease, in ABA signaling, remains largely unknown. Here, we show that the SUMO protease, ASP1 positively regulates ABA signaling. Mutations in ASP1 resulted in an ABA-insensitive phenotype, during early seedling development. Wild-type ASP1 successfully rescued, whereas an ASP1 mutant (C577S), defective in SUMO protease activity, failed to rescue, the ABA-insensitive phenotype of asp1-1...
May 22, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29786826/rare-case-of-bilateral-incarcerated-obturator-hernia-a-case-report
#3
Engin Hatipoğlu, Fatih Dal, Veysel Umman, Süleyman Demiryas, Oktay Demirkıran, Metin Ertem, Sabri Ergüney, Salih Pekmezci
Here, we report the case of an 84-year-old woman with acute mechanical intestinal obstruction (AMIO) who was admitted to our Emergency Department. Computed tomography (CT) scan revealed an incarcerated bilateral obturator hernia, and the defect was resolved using transabdominal preperitoneal (TAPP) technique with polypropylene mesh. The patient was administered an oral regimen two days after the operation. The patient stayed in the intensive care unit for 4 days and was uneventfully discharged on the 9th postoperative day...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786783/a-xenograft-model-for-venous-malformation
#4
Jillian Goines, Xian Li, Yuqi Cai, Paula Mobberley-Schuman, Megan Metcalf, Steven J Fishman, Denise M Adams, Adrienne M Hammill, Elisa Boscolo
Vascular malformations are defects caused by the abnormal growth of the vasculature. Among them, venous malformation (VM) is an anomaly characterized by slow-flow vascular lesions with abnormally shaped veins, typically in sponge-like configuration. VMs can expand over years causing disfigurement, obstruction of vital structures, thrombosis, bleeding, and pain. Treatments have been very limited and primarily based on supportive care, compression garments, sclerotherapy, and/or surgical resection. Sirolimus treatment has recently shown efficacy in some patients with complicated vascular anomalies, including VMs...
May 21, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29786743/role-of-tgf%C3%A2-%C3%AE-1-expressed-in-bone-marrow%C3%A2-derived-mesenchymal-stem-cells-in-promoting-bone-formation-in-a-rabbit-femoral-defect-model
#5
Bing-Yin Sun, Bao-Xiang Zhao, Jie-Ying Zhu, Zheng-Ping Sun, Yong-An Shi, Feng Huang
Bone defects represent a major clinical and socioeconomic problem without suitable treatment options. Previous studies have shown that transforming growth factor β1 (TGF‑β1) is important in the development of various diseases. The present study aimed to investigate the therapeutic potential of rabbit bone marrow‑derived mesenchymal stem cells (BMSCs) expressing TGF‑β1 in the treatment of rabbit femoral defects. First, rabbit BMSCs were identified and cultured. TGF‑β1 was then stably overexpressed in the rabbit BMSCs by lentivirus transfection, which was expressed at a high level in the femoral defects treated with TGF‑β1‑overexpressing BMSCs, compared with PBS‑treated controls...
May 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29786739/synthesis-of-pure-silica-mfi-zeolites-using-imidazolium-based-long-dications-a-comparative-study-of-structure-directing-effects-derived-from-a-further-spacer-length-increase
#6
Peng Lu, Luis Gómez-Hortigüela, Miguel A Camblor
Length-dependent structure direction of linear methylimidazolium-based dications towards MFI zeolite, previously known only for the tetramethylene spacer, has also been found for octamethylene and decamethylene spacers. This works only under highly concentrated conditions, whereas dilution always tends to favor TON, a default structure that is the only zeolite obtained with the other reported dications (with tri-, penta-, and hexamethylene spacers). The locations and conformations of the dications have been studied by molecular mechanics simulations...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29786701/lutembacher-syndrome-with-mitral-valve-calcification-in-a-31-year-old-male
#7
Arsalan Majeed Adam, Ansab Godil, Muhammad Saad Ali Mallick, Fahad Khan, Ather Hasan Rizvi, Inam-Ul-Haq Muhammad Makhdoom
Lutembacher syndrome is characterized by a congenital ostium secundum atrial septal defect and an acquired mitral valve stenosis. We present a similar case in a 31-year old male who came in with orthopnoea, central cyanosis and pedal oedema. Examination revealed cardiac murmurs in tricuspid and apical regions. Chest x-ray showed signs of pulmonary congestion and ventricular enlargement. Electrocardiogaphy (ECG) revealed right axis deviation and right bundle branch block along with atrial fibrillation and Transthoracic Echocardiography (TTE) showed abnormal valves (mitral stenosis with calcification and tricuspid regurgitation) and dilated cardiac chambers...
February 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29786563/cell-based-liver-therapies-past-present-and-future
#8
REVIEW
Valeria Iansante, Anil Chandrashekran, Anil Dhawan
Liver transplantation represents the standard treatment for people with an end-stage liver disease and some liver-based metabolic disorders; however, shortage of liver donor tissues limits its availability. Furthermore, whole liver replacement eliminates the possibility of using native liver as a possible target for future gene therapy in case of liver-based metabolic defects. Cell therapy has emerged as a potential alternative, as cells can provide the hepatic functions and engraft in the liver parenchyma...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786553/from-skeletal-development-to-the-creation-of-pluripotent-stem-cell-derived-bone-forming-progenitors
#9
REVIEW
Wai Long Tam, Frank P Luyten, Scott J Roberts
Bone has many functions. It is responsible for protecting the underlying soft organs, it allows locomotion, houses the bone marrow and stores minerals such as calcium and phosphate. Upon damage, bone tissue can efficiently repair itself. However, healing is hampered if the defect exceeds a critical size and/or is in compromised conditions. The isolation or generation of bone-forming progenitors has applicability to skeletal repair and may be used in tissue engineering approaches. Traditionally, bone engineering uses osteochondrogenic stem cells, which are combined with scaffold materials and growth factors...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786414/uncovering-the-design-principle-of-amino-acid-derived-photoluminescent-bio-dots-with-tailored-made-structure-properties-and-application-for-cellular-bioimaging
#10
Hesheng Victor Xu, Xinting Zheng, Yanli Zhao, Yen Nee Tan
Natural amino acids possess side chains with different functional groups (R groups), which make them excellent precursors for programmable synthesis of biomolecule-derived nanodots (bio-dots) with desired properties. Herein, we reported the first systematic study to uncover the material design rules of bio-dots synthesis from 20 natural α-amino acids via a green hydrothermal approach. The as-synthesized amino acids bio-dots (AA-dots) are comprehensively characterised to establish a structure-properties relationship between the amino acid precursors and the corresponding photoluminescent properties of AA-dots...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786190/-identification-of-a-new-mutation-of-the-nphp1-gene
#11
Antonella La Russa, Rosa Anna Cifarelli, Anna Perri, Angelo Saracino, Giovanni Santarsia, Renzo Bonofiglio
Kidney cystic diseases are inherited disorders causing chronic renal failure. According to the genetic defect they are classified as diseases of the primary ciliary complex and uromodulin-associated diseases. Mutations in genes coding for ciliary proteins are the basis of a broad category of genetic diseases, called ciliopathies. To date, three important ciliopathies are known: the autosomal dominant form and the recessive shape of the polycystic kidney and the nephronophthisis (NPHP). Juvenile Nephronophthisis (NPHP) is a progressive renal tubulo-interstitial disorder with a form of autosomal recessive inheritance that progresses inexorably towards terminal renal failure...
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29786119/full-length-and-defective-enterovirus-g-genomes-with-distinct-torovirus-protease-insertions-are-highly-prevalent-on-a-chinese-pig-farm
#12
Yan Wang, Wen Zhang, Zhijian Liu, Xingli Fu, Jiaqi Yuan, Jieji Zhao, Yuan Lin, Quan Shen, Xiaochun Wang, Xutao Deng, Eric Delwart, Tongling Shan, Shixing Yang
Recombination occurs frequently between enteroviruses (EVs) which are classified within the same species of the Picornaviridae family. Here, using viral metagenomics, the genomes of two recombinant EV-Gs (strains EVG 01/NC_CHI/2014 and EVG 02/NC_CHI/2014) found in the feces of pigs from a swine farm in China are described. The two strains are characterized by distinct insertion of a papain-like protease gene from toroviruses classified within the Coronaviridae family. According to recent reports the site of the torovirus protease insertion was located at the 2C/3A junction region in EVG 02/NC_CHI/2014...
May 21, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29785947/-n-wasp-regulates-cortical-neuron-migration-through-its-polypro-and-vca-domains
#13
Xiu Lian Shen, Yi Chao Lu, Zhi Lian Jia, Qiang Wu
Cortical neuron migration in the developing mouse forebrain is a complex process, which contains several steps related to cytoskeleton dynamics and remodeling. Neural Wiskott-Aldrich syndrome protein (N-WASP), a member of the WASP-WAVE family, regulates actin cytoskeleton reorganization through the binding of its VCA domain to the Arp2/3 complex. Here we report expression patterns of N-WASP gene in the mouse developing embryonic cortex (E12.5~ E18.5) and find its expression levels are decreased during embryonic development...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29785886/treatment-of-homozygous-familial-hypercholesterolaemia-in-paediatric-patients-a-monocentric-experience
#14
Paola S Buonuomo, Marina Macchiaiolo, Giovanna Leone, Paola Valente, Gerarda Mastrogiorgio, Maria Gnazzo, Ippolita Rana, Michaela V Gonfiantini, Maria G Gagliardi, Francesca Romano, Andrea Bartuli
Background Homozygous familial hypercholesterolaemia is a rare life-threatening disease characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) concentrations and accelerated atherosclerosis. The presence of double gene defects in the LDL-Receptor, either the same defect (homozygous) or two different LDL-raising mutations (compound heterozygotes) or other variants, identify the homozygous phenotype (HopFH). Apheresis is a procedure in which plasma is separated from red blood cells before the physical removal of LDL-C or the LDL-C is directly removed from whole blood...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29785850/performance-enhancement-of-inverted-perovskite-solar-cells-based-on-smooth-and-compact-pc61bm-sno2-electron-transport-layers
#15
Yao Wang, Chenghao Duan, Jiangsheng Li, Wei Han, Min Zhao, Lili Yao, Yuanyuan Wang, Chao Yan, Tonggang Jiu
In this work, PC61BM:SnO2 electron transport layers (ETLs) were applied in inverted CH3NH3PbI3 perovskite solar cells and a high power conversion efficiency of 19.7% could be obtained. It increased by 49.0% in comparison with the device based on PC61BM-only ETL (13.2%). SnO2 nanocrystals with excellent dispersibility were employed here to fill the pin-holes and cover the valleys of PC61BM layer, forming smooth and compact PC61BM:SnO2 layers. Simultaneously, the electron traps caused by deep-level native defects of SnO2 were reduced by PC61BM proved by the space charge limited current analysis...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29785536/wnt3a-promotes-differentiation-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-cementoblast-like-cells
#16
Yusuke Aida, Hidemi Kurihara, Koichi Kato
Cementum is a calcified, avascular connective tissue that laminates the root of a tooth and plays a pivotal role in the development, homeostasis, and regeneration of a periodontal tissue. As a potential treatment for periodontal tissue defects in the patient with chronic periodontitis, much attention has been paid to tissue engineering combined with mesenchymal stem cells for regenerating periodontal tissues including cementum. However, limited information is available for the molecular factors that have impacts on the differentiation of mesenchymal stem cells into cementoblasts...
May 21, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29785443/organic-inorganic-hybrid-perovskite-quantum-dots-with-high-plqy-and-enhanced-carrier-mobility-through-crystallinity-control-by-solvent-engineering-and-solid-state-ligand-exchange
#17
Jin Woo Choi, Hee Chul Woo, Xiaoguang Huang, Wan-Gil Jung, Bong-Joong Kim, Sie-Wook Jeon, Sang-Youp Yim, Jae-Suk Lee, Chang-Lyoul Lee
The photoluminescence quantum yield (PLQY) and charge carrier mobility of organic-inorganic perovskite QDs were enhanced by the optimization of crystallinity and surface passivation as well as solid-state ligand exchange. The crystallinity of perovskite QDs was determined by the Effective solvent field (Esol) of various solvents for precipitation. The solvent with high Esol could more quickly countervail the localized field generated by the polar solvent, and it causes fast crystallization of the dissolved precursor, which results in poor crystallinity...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29785267/a-silent-massive-ossification-of-achilles-tendon-as-a-suspected-rare-late-effect-of-surgery-for-club-foot
#18
Francesco Manfreda, Paolo Ceccarini, Marco Corzani, Rosario Petruccelli, Pierluigi Antinolfi, Giuseppe Rinonapoli, Auro Caraffa
We report the case of a 66-year-old male patient with massive ossification of the distal portion of the Achilles tendon, as a late consequence of a surgical release for club foot conducted in his childhood. The singularity of the case report derives from its clinical features: the bone mass was of abnormal dimensions, almost substituting the entire tendon; the condition had always been asymptomatic, without deficits in range of motion, in absence of either pain or biomechanical defects with age. In fact, the condition was diagnosed just recently as a consequence of a tear...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29785222/proximal-femoral-bone-regeneration-after-an-uncemented-hydroxyapatite-coated-long-stem-in-revision-hip-surgery
#19
José Cordero-Ampuero, Eduardo Garcia-Rey, Eduardo Garcia-Cimbrelo
Background: Bone remodelling with lateral femoral cortex thinning is a major concern after extensively porous-coated long-stem in revision surgery. Extensive hydroxyapatite coated long-stems were introduced to improve osseointegration, but bone remodelling changes have not been quantified. Objective: The question of whether bone remodelling changes from extensive hydroxyapatite-coated long stems influence the durability of femoral revision, clinical outcome is assessed in follow-up radiographs...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29785213/a-case-series-and-review-of-bacillus-cereus-endocarditis-from-india
#20
Anusha Gopinathan, Anil Kumar, Amitabh C Sen, Srisruthy Sudha, Praveen Varma, Sunil Gs, Malini Eapen, Kavitha R Dinesh
Introduction: Bacillus cereus is a gram positive bacilli found commonly in the soil and environment. It is a bacteria rarely associated with endocarditis. Case History: Intravenous drug abuse, presence of valvular defects, pacemakers, immunodeficiency are some of the known risk factors for B.cereus endocarditis. We present here a case series of two patients with B.cereus endocarditis along with a review of the literature. Conclusion: This is the first report of B...
2018: Open Microbiology Journal
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