Jie Tong, Jiangwei Song, Wuchao Zhang, Jingbo Zhai, Qingli Guan, Huiqing Wang, Gentao Liu, Chunfu Zheng
When cells proliferate, stress on DNA replication or exposure to endogenous or external insults frequently results in DNA damage. DNA-Damage Response (DDR) networks are complex signaling pathways used by multicellular organisms to prevent DNA damage. Depending on the type of broken DNA, the various pathways, Base-Excision Repair (BER), Nucleotide Excision Repair (NER), Mismatch Repair (MMR), Homologous Recombination (HR), Non-Homologous End-Joining (NHEJ), Interstrand Crosslink (ICL) repair, and other direct repair pathways, can be activated separately or in combination to repair DNA damage...
April 17, 2024: Cellular and Molecular Life Sciences: CMLS