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https://www.readbyqxmd.com/read/27762527/post-partum-angiopathy-presenting-as-ischemic-stroke
#1
Pooja Gupta, Anshu Rohatgi, Samir Patel
Post-partum angiopathy is grouped within the category of reversible cerebral vasoconstriction syndromes. It is considered to be a rare but under-recognized cause of stroke especially in pregnancy. We present the case of a 24 year old female who presented with hemiparesis and seizure, and turned out to be a case of post partum angiopathy.
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27726164/limitations-of-the-hcmec-d3-cell-line-as-a-model-for-a%C3%AE-clearance-by-the-human-blood-brain-barrier
#2
Elisanne Alm Biemans, Lieke Jäkel, Robert Mw de Waal, H Bea Kuiperij, Marcel M Verbeek
Alzheimer's disease and cerebral amyloid angiopathy are characterized by accumulation of amyloid-β (Aβ) at the cerebrovasculature due to decreased clearance at the blood-brain barrier (BBB). However, the exact mechanism of Aβ clearance across this barrier has not been fully elucidated. The hCMEC/D3 cell line has been characterized as a valid model for the BBB. In this study we evaluated the use of this model to study Aβ clearance across the BBB, with an emphasis on brain-to-blood directional permeability...
October 11, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27640182/the-critical-care-management-of-spontaneous-intracranial-hemorrhage-a-contemporary-review
#3
REVIEW
Airton Leonardo de Oliveira Manoel, Alberto Goffi, Fernando Godinho Zampieri, David Turkel-Parrella, Abhijit Duggal, Thomas R Marotta, R Loch Macdonald, Simon Abrahamson
Spontaneous intracerebral hemorrhage (ICH), defined as nontraumatic bleeding into the brain parenchyma, is the second most common subtype of stroke, with 5.3 million cases and over 3 million deaths reported worldwide in 2010. Case fatality is extremely high (reaching approximately 60 % at 1 year post event). Only 20 % of patients who survive are independent within 6 months. Factors such as chronic hypertension, cerebral amyloid angiopathy, and anticoagulation are commonly associated with ICH. Chronic arterial hypertension represents the major risk factor for bleeding...
September 18, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27618323/white-matter-diseases-with-radiologic-pathologic-correlation
#4
Nicolae Sarbu, Robert Y Shih, Robert V Jones, Iren Horkayne-Szakaly, Laura Oleaga, James G Smirniotopoulos
White matter diseases include a wide spectrum of disorders that have in common impairment of normal myelination, either by secondary destruction of previously myelinated structures (demyelinating processes) or by primary abnormalities of myelin formation (dysmyelinating processes). The pathogenesis of many white matter diseases remains poorly understood. Demyelinating disorders are the object of this review and will be further divided into autoimmune, infectious, vascular, and toxic-metabolic processes. Autoimmune processes include multiple sclerosis and related diseases: tumefactive demyelinating lesions, Balo concentric sclerosis, Marburg and Schilder variants, neuromyelitis optica (Devic disease), acute disseminated encephalomyelitis, and acute hemorrhagic leukoencephalopathy (Hurst disease)...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/26910197/distinguishing-clinical-and-radiological-features-of-non-traumatic-convexal-subarachnoid-hemorrhage
#5
J Graff-Radford, J E Fugate, J Klaas, K D Flemming, R D Brown, A A Rabinstein
BACKGROUND AND PURPOSE: The full spectrum of causes of convexal subarachnoid hemorrhage (cSAH) requires further investigation. Therefore, our objective was to describe the spectrum of clinical and imaging features of patients with non-traumatic cSAH. METHODS: A retrospective observational study of consecutive patients with non-traumatic cSAH was performed at a tertiary referral center. The underlying cause of cSAH was characterized and clinical and imaging features that predict a specific etiology were identified...
May 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/26890776/cerebral-amyloid-angiopathy-caa-related-inflammation-comparison-of-inflammatory-caa-and-amyloid-%C3%AE-related-angiitis
#6
Shuguang Chu, Feijia Xu, Ya Su, Hong Chen, Xin Cheng
Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a relatively rare syndrome of reversible encephalopathy and could be divided into two subtypes of inflammatory CAA (ICAA) and amyloid-β-related angiitis (ABRA) according to histopathology. We present a case of pathologically proved ABRA with partial seizures and headache, and a focal lesion in the right temporal lobes on magnetic resonance imaging. Summarized from previous 139 ABRA and ICAA cases, ABRA is preferred when the lesion is enhanced on MRI and requires combination drug therapy, while ICAA is highly suspected with ApoE genotype of ɛ4/ɛ4...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26842068/pharmacological-removal-of-serum-amyloid-p-component-from-intracerebral-plaques-and-cerebrovascular-a%C3%AE-amyloid-deposits-in-vivo
#7
Raya Al-Shawi, Glenys A Tennent, David J Millar, Angela Richard-Londt, Sebastian Brandner, David J Werring, J Paul Simons, Mark B Pepys
Human amyloid deposits always contain the normal plasma protein serum amyloid P component (SAP), owing to its avid but reversible binding to all amyloid fibrils, including the amyloid β (Aβ) fibrils in the cerebral parenchyma plaques and cerebrovascular amyloid deposits of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). SAP promotes amyloid fibril formation in vitro, contributes to persistence of amyloid in vivo and is also itself directly toxic to cerebral neurons. We therefore developed (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC), a drug that removes SAP from the blood, and thereby also from the cerebrospinal fluid (CSF), in patients with AD...
February 2016: Open Biology
https://www.readbyqxmd.com/read/26729476/pulsations-with-reflected-boundary-waves-a-hydrodynamic-reverse-transport-mechanism-for-perivascular-drainage-in-the-brain
#8
M Coloma, J D Schaffer, R O Carare, P R Chiarot, P Huang
Beta-amyloid accumulation within arterial walls in cerebral amyloid angiopathy is associated with the onset of Alzheimer's disease. However, the mechanism of beta-amyloid clearance along peri-arterial pathways in the brain is not well understood. In this study, we investigate a transport mechanism in the arterial basement membrane consisting of forward-propagating waves and their reflections. The arterial basement membrane is modeled as a periodically deforming annulus filled with an incompressible single-phase Newtonian fluid...
August 2016: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/26491895/imaging-of-cerebrovascular-disease-in-pregnancy-and-the-puerperium
#9
REVIEW
Lotfi Hacein-Bey, Panayiotis N Varelas, John L Ulmer, Leighton P Mark, Kesav Raghavan, James M Provenzale
OBJECTIVE: The purpose of this article is to review the unique physiologic changes that characterize pregnancy and the puerperium, some that substantially affect the cerebrovascular system. Conditions that can cause neurologic deterioration and share features with preeclampsia-eclampsia include postpartum angiopathy, reversible cerebral vasoconstriction syndrome, posterior reversible encephalopathy syndrome, and amniotic fluid embolism. Other conditions not specific to this patient group include cerebral venous thrombosis, cervicocephalic arterial dissection, ischemic stroke, and hemorrhagic stroke, which can pose specific diagnostic and therapeutic challenges...
January 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/26471406/cerebral-amyloid-angiopathy-related-inflammation-a-potentially-reversible-cause-of-dementia-with-characteristic-imaging-findings
#10
Prashant Raghavan, Seamus Looby, T David Bourne, Max Wintermark
BACKGROUND AND PURPOSE: Cerebral amyloid angiopathy with inflammation (CAA-I) is a less well-recognized clinically and radiologically distinct subtype of CAA. We aim to describe the imaging manifestations of this uncommon entity. MATERIALS AND METHODS: A retrospective review of the medical records and imaging database yielded 9 patients with clinical and radiological findings compatible with CAA-I. The neurological findings at presentation, MRI findings including the presence of white matter involvement, mass effect, microhemorrhages and contrast enhancement, treatment provided and outcome were evaluated...
February 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/26142259/stroke-like-episodes-heralding-a-reversible-encephalopathy-microbleeds-as-the-key-to-the-diagnosis-of-cerebral-amyloid-angiopathy-related-inflammation-a-case-report-and-literature-review
#11
REVIEW
Marcelo D Mendonça, André Caetano, Miguel Pinto, Vera Cruz e Silva, Miguel Viana-Baptista
BACKGROUND: Cerebral amyloid angiopathy (CAA) is a common, often asymptomatic disease. Lobar intracerebral hemorrhage is the most frequent manifestation of CAA. Nevertheless, presentation of CAA with subacute cognitive decline, seizures, or headache with concomitant hyperintensities on T2-weighted magnetic resonance imaging (MRI) sequences and neuropathologic evidence of inflammation has been described. This disorder is known as CAA-related inflammation (CAA-ri). METHODS: Description of a stroke-like presentation of CAA-ri and systematic review of case reports and case series of CAA-ri...
September 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26096511/the-inflammatory-form-of-cerebral-amyloid-angiopathy-or-cerebral-amyloid-angiopathy-related-inflammation-caari
#12
REVIEW
Howard S Kirshner, Michael Bradshaw
Cerebral amyloid angiopathy-related inflammation (CAARI) is a recently recognized syndrome of reversible encephalopathy seen in a subset of patients with cerebral amyloid angiopathy (CAA). CAA is a disorder of the elderly in which amyloid peptides are deposited in the walls of cerebral arteries, leading to microhemorrhages, macrohemorrhages, and eventually dementia. In a few cases, the amyloid deposition is accompanied by inflammation or edema. The clinical syndrome of CAARI is distinguished by subacute neurobehavioral symptoms, headaches, seizures, and stroke-like signs, contrasting the acute intracranial hemorrhage typically seen in CAA...
August 2015: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/26088185/intracranial-cerebral-artery-dissection-of-anterior-circulation-as-a-cause-of-convexity-subarachnoid-hemorrhage
#13
Kazuki Fukuma, Masafumi Ihara, Tomotaka Tanaka, Yoshiaki Morita, Kazunori Toyoda, Kazuyuki Nagatsuka
BACKGROUND: Convexity subarachnoid hemorrhage (cSAH), defined as intrasulcal bleeding restricted to hemispheric convexities, has several etiologies: reversible cerebral vasoconstriction syndrome, cerebral amyloid angiopathy, and internal carotid artery (ICA) stenosis or occlusion. However, it remains unknown whether cerebral artery dissection causes cSAH. METHODS: We retrospectively investigated patients admitted to our hospital between 2005 and 2013 with ischemic stroke or transient ischemic attack caused by cerebral artery dissection...
2015: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/25926467/centrally-delivered-bace1-inhibitor-activates-microglia-and-reverses-amyloid-pathology-and-cognitive-deficit-in-aged-tg2576-mice
#14
Deepak R Thakker, Sethu Sankaranarayanan, Marcy R Weatherspoon, Jonathan Harrison, Maria Pierdomenico, Jennifer M Heisel, Lorin A Thompson, Roy Haskell, James E Grace, Sarah J Taylor, Charles F Albright, Lisa L Shafer
Multiple small-molecule inhibitors of the β-secretase enzyme (BACE1) are under preclinical or clinical investigation for Alzheimer's disease (AD). Prior work has illustrated robust lowering of central amyloid β (Aβ) after acute administration of BACE1 inhibitors. However, very few studies have assessed the overall impact of chronically administered BACE1 inhibitors on brain amyloid burden, neuropathology, and behavioral function in aged preclinical models. We investigated the effects of a potent nonbrain-penetrant BACE1 inhibitor, delivered directly to the brain using intracerebroventricular infusion in an aged transgenic mouse model...
April 29, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25922539/antithrombotic-treatment-and-intracerebral-haemorrhage-between-scylla-and-charybdis
#15
REVIEW
J Hofmeijer, L J Kappelle, C J M Klijn
In patients who have intracerebral haemorrhage while on antithrombotic treatment, there is no evidence from randomised clinical trials to support decisions with regard to antithrombotic medication. In the acute phase, we advise stopping all antithrombotic treatment with rapid reversal of antithrombotic effects of oral anticoagulants. After the acute phase, we discourage restarting oral anticoagulants in patients with a lobar haematoma caused by cerebral amyloid angiopathy because of the high risk of recurrent bleeding...
August 2015: Practical Neurology
https://www.readbyqxmd.com/read/25860345/clinical-spectrum-underlying-etiologies-and-radiological-characteristics-of-cortical-superficial-siderosis
#16
Nina Lummel, Frank Arne Wollenweber, Philippe Demaerel, Katja Bochmann, Rainer Malik, Christian Opherk, Jennifer Linn
Cortical superficial siderosis (cSS) is an increasingly recognized MR-imaging marker most probably caused by focal convexity subarachnoid hemorrhage (SAH). There is accumulating evidence that cSS represents an important risk factor for subsequent intracranial hemorrhages. Here, we aimed to determine clinical symptoms, underlying etiologies, and radiological characteristics of cSS in a large patient cohort. We performed an electronic database search on all patients who presented between 2002 and 2013 to the university hospital Munich with non-traumatic and non-aneurysmal cSS...
June 2015: Journal of Neurology
https://www.readbyqxmd.com/read/25821615/acute-dysphasia-and-reversible-cognitive-decline-in-a-patient-with-probable-cerebral-amyloid-angiopathy-related-inflammation
#17
Louise Rigney, Dale Sebire, Dennis Cordato
Cerebral amyloid angiopathy related inflammation (CAAri) is becoming increasingly recognised as a subset of cerebral amyloid angiopathy (CAA). CAAri generally presents with subacute cognitive decline, headaches, seizures, behavioral changes, and focal neurological deficits. We describe a patient who developed acute dysphasia and reversible cognitive decline due to probable CAAri. CT brain showed bilateral vasogenic edema in the cerebral hemispheres, predominantly involving the parietal and temporal lobes, left greater than right without enhancement...
2015: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/25761676/severe-adverse-effects-of-bromocriptine-in-lactation-inhibition-a-pharmacovigilance-survey
#18
N Bernard, H Jantzem, M Becker, C Pecriaux, A Bénard-Laribière, J L Montastruc, J Descotes, T Vial
OBJECTIVE: To assess the nature and conditions of the occurrence of adverse drug reactions (ADRs) of bromocriptine, which is used to inhibit lactation. DESIGN: Observational study. SETTING: Cases from the French pharmacovigilance database and the marketing authorisation holders. SAMPLE: Serious ADRs reported between 1994 and 2010 in association with bromocriptine used for lactation inhibition in France. METHODS: Each case was checked to confirm the bromocriptine indication, the seriousness of the ADR, the modalities of bromocriptine use, and to identify possible associated predisposing factors...
August 2015: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/25288671/diabetic-microangiopathy-impact-of-impaired-cerebral-vasoreactivity-and-delayed-angiogenesis-after-permanent-middle-cerebral-artery-occlusion-on-stroke-damage-and-cerebral-repair-in-mice
#19
Marine Poittevin, Philippe Bonnin, Cynthia Pimpie, Léa Rivière, Catherine Sebrié, Anthony Dohan, Marc Pocard, Christiane Charriaut-Marlangue, Nathalie Kubis
Diabetes increases the risk of stroke by three, increases related mortality, and delays recovery. We aimed to characterize functional and structural alterations in cerebral microvasculature before and after experimental cerebral ischemia in a mouse model of type 1 diabetes. We hypothesized that preexisting brain microvascular disease in patients with diabetes might partly explain increased stroke severity and impact on outcome. Diabetes was induced in 4-week-old C57Bl/6J mice by intraperitoneal injections of streptozotocin (60 mg/kg)...
March 2015: Diabetes
https://www.readbyqxmd.com/read/25239155/cerebrovascular-complications-of-pregnancy-and-the-postpartum-period
#20
REVIEW
Ali Razmara, Khamid Bakhadirov, Ayush Batra, Steven K Feske
Cerebrovascular complications of pregnancy, though uncommon, threaten women with severe morbidity or death, and they are the main causes of major long-term disability associated with pregnancy. In this review, we discuss the epidemiology, pathophysiology, presentation and diagnosis, and management and outcomes of ischemic and hemorrhagic stroke and cerebral venous thrombosis. We also discuss the posterior reversible encephalopathy syndrome, the reversible cerebral vasoconstriction syndrome including postpartum cerebral angiopathy, and their relationship as overlapping manifestations of pre-eclampsia-eclampsia...
2014: Current Cardiology Reports
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