Federica Rinaldi, Patrizia Nadia Hanieh, Linda Maurizi, Catia Longhi, Daniela Uccelletti, Emily Schifano, Elena Del Favero, Laura Cantù, Caterina Ricci, Maria Grazia Ammendolia, Donatella Paolino, Francesca Froiio, Carlotta Marianecci, Maria Carafa
PURPOSE: Vitamin E (VitE) may be classified in "the first line of defense" against the formation of reactive oxygen species. Its inclusion in nanoemulsions (NEs) is a promising alternative to increase its bioavailability. The aim of this study was to compare O/W NEs including VitE based on Almond or Neem oil, showing themselves antioxidant properties. The potential synergy of the antioxidant activities of oils and vitamin E, co-formulated in NEs, was explored. PATIENTS AND METHODS: NEs have been prepared by sonication and deeply characterized evaluating size, ζ-potential, morphology (TEM and SAXS analyses), oil nanodroplet feature, and stability...
2022: International Journal of Nanomedicine