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Isabel Lopez-Oliva, Akshay D Paropkari, Shweta Saraswat, Stefan Serban, Zehra Yonel, Praveen Sharma, Paola de Pablo, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich, Melissa M Grant, Purnima S Kumar
OBJECTIVES: Studies that demonstrate an association between rheumatoid arthritis (RA) and dysbiotic oral microbiomes are often confounded by the presence of extensive periodontitis in these individuals. Therefore, the present investigation sought to investigate the role of RA in modulating the periodontal microbiome by comparing periodontally healthy individuals with and without RA. METHODS: Subgingival plaque was collected from was collected periodontally healthy individuals (22 with and 19 without RA), and 16S gene sequenced on the Ilumina MiSeq platform...
March 7, 2018: Arthritis & Rheumatology
Zehra Yonel, Abisola Asuni, Pankaj Taneja
AIMS: To review the literature, to investigate whether there was aconsensus on what encompasses over-sedation, and to determine the guidance employed for the administration of flumazenil. METHODS: A literature search was performed following which a self-designed questionnaire was emailed to 14 sedation leads within UK Dental Hospitals. RESULTS: 10 documents in the literature review met the inclusion criteria. In their definitions of over-sedation, loss of consciousness and respiratory depression were the main terms used; but a variety of terms were also seen, indicating a lack of agreement...
January 2016: SAAD Digest
Zehra Yonel, Sabrina Parma, Iain L C Chapple
Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive inherited condition presenting early in life and characterized by the accumulation of hyaline-like tissue in the skin as well as various organs. Gingival overgrowth is a significant oral manifestation. This paper highlights how early and essential periodontal intervention may be necessary to improve mastication and subsequent weight gain, and to eliminate pain and improve the patient's quality of life. Here we highlight the key features of this condition and demonstrate how appropriate surgical management can have a significant impact on a patient's wellbeing...
September 2015: Dental Update
Alexis Buitrago, Janne Rojas, Luis Rojas, Judith Velasco, Antonio Morales, Yonel Peñaloza, Clara Díaz
Hydrodistillation of Vismia macrophylla Kunth (Hypericaceae) leaves (L) and fruits (F) yielded 1.3%, v/w, and 5.6%, v/w, of essential oil, respectively. GC and GC-MS analyses showed the presence of twenty-four (96.4%, L) and thirty-one (96.6%, F) components, respectively. Major compounds identified in the leaf oil were γ-bisabolene (44.4%) and β-bisabolol (14.9%), while those in the fruit oil were germacrene-D (12.1%), 6-cadinene (10.7%) and γ-bisabolene (22.3 %). Oil obtained from the fruits of V. macrophylla showed antibacterial activity against Gram-positive (S...
February 2015: Natural Product Communications
Glauco R Souza, Esra Yonel-Gumruk, Davin Fan, Jeffrey Easley, Roberto Rangel, Liliana Guzman-Rojas, J Houston Miller, Wadih Arap, Renata Pasqualini
Hydrogels have become a promising research focus because of their potential for biomedical application. Here we explore the long-range, electrostatic interactions by following the effect of trans-acting (pH) and cis-acting factors (peptide mutation) on the formation of Au-phage hydrogels. These bioinorganic hydrogels can be generated from the bottom-up assembly of Au nanoparticles (Au NP) with either native or mutant bacteriophage (phage) through electrostatic interaction of the phage pVIII major capsid proteins (pVIII)...
2008: PloS One
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