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https://www.readbyqxmd.com/read/28528664/enhanced-lc-ms-ms-analysis-of-alogliptin-and-pioglitazone-in-human-plasma-applied-to-a-preliminary-pharmacokinetic-study
#1
Maha F Abdel-Ghany, Miriam F Ayad, Mariam M Tadros
A new fast LC-MS/MS method was developed for determination of alogliptin and pioglitazone in human plasma. Linearity ranges of 10-400ngmL(-1) for alogliptin and 25-2000ngmL(-1) for pioglitazone, were found to be suitable for their bioanalysis covering the Cmin and Cmax values of the drugs. Direct precipitation technique was used for simultaneous extraction of the drugs successfully from human plasma samples. Chromatographic separation was achieved on a BEH C18 column (50mm×2.1mm, 1.7μm) with 0.1% aqueous formic acid: acetonitrile (40:60, v/v) at a flow rate of 0...
April 26, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28526664/effect-of-a-counseling-session-bolstered-by-text-messaging-on-self-selected-health-behaviors-in-college-students-a-preliminary-randomized-controlled-trial
#2
Janice Sandrick, Doreen Tracy, Arn Eliasson, Ashley Roth, Jeffrey Bartel, Melanie Simko, Tracy Bowman, Karen Harouse-Bell, Mariam Kashani, Marina Vernalis
BACKGROUND: The college experience is often the first time when young adults live independently and make their own lifestyle choices. These choices affect dietary behaviors, exercise habits, techniques to deal with stress, and decisions on sleep time, all of which direct the trajectory of future health. There is a need for effective strategies that will encourage healthy lifestyle choices in young adults attending college. OBJECTIVE: This preliminary randomized controlled trial tested the effect of coaching and text messages (short message service, SMS) on self-selected health behaviors in the domains of diet, exercise, stress, and sleep...
May 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28511456/acute-rubella-virus-infection-among-women-with-spontaneous-abortion-in-mwanza-city-tanzania
#3
Lukombodzo Lulandala, Mariam M Mirambo, Dismas Matovelo, Balthazar Gumodoka, Stephen E Mshana
INTRODUCTION: Acute rubella virus infection in early pregnancy has been associated with poor pregnancy outcome ranging from spontaneous abortion, stillbirth and multiple birth defects known as Congenital Rubella Syndrome (CRS). Despite its importance the prevalence of acute rubella virus infections is not known among women with spontaneous abortion in most centres in developing countries. AIM: The present study was aimed to determine the seroprevalence of acute rubella infection among women with spontaneous abortion in Mwanza city...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28507553/virus-bacteria-rice-co-infection-in-africa-field-estimation-reciprocal-effects-molecular-mechanisms-and-evolutionary-implications
#4
Charlotte Tollenaere, Severine Lacombe, Issa Wonni, Mariam Barro, Cyrielle Ndougonna, Fatoumata Gnacko, Drissa Sérémé, Jonathan M Jacobs, Eugénie Hebrard, Sebastien Cunnac, Christophe Brugidou
Simultaneous infection of a single plant by various pathogen species is increasingly recognized as an important modulator of host resistance and a driver of pathogen evolution. Because plants in agro-ecosystems are the target of a multitude of pathogenic microbes, co-infection could be frequent, and consequently important to consider. This is particularly true for rapidly intensifying crops, such as rice in Africa. This study investigated potential interactions between pathogens causing two of the major rice diseases in Africa: the Rice yellow mottle virus (RYMV) and the bacterium Xanthomonas oryzae pathovar oryzicola (Xoc) in order to: 1/ document virus-bacteria co-infection in rice in the field, 2/ explore experimentally their consequences in terms of symptom development and pathogen multiplication, 3/ test the hypothesis of underlying molecular mechanisms of interactions and 4/ explore potential evolutionary consequences...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28503674/identifying-brain-nociceptive-information-transmission-in-patients-with-chronic-somatic-pain
#5
Don A Davis, Mariam E Ghantous, Melissa A Farmer, Alexis T Baria, A Vania Apkarian
INTRODUCTION: Recent advances regarding mechanisms of chronic pain emphasize the role of corticolimbic circuitry in predicting risk for chronic pain, independently from site of injury-related parameters. These results compel revisiting the role of peripheral nociceptive signaling in chronic pain. We address this issue by examining what brain circuitry transmit information regarding the intensity of chronic pain and how this information may be related to a common co-morbidity, depression...
October 2016: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/28503623/seven-digit-creatine-kinase-in-acute-rhabdomyolysis-in-a-child
#6
Nuha Basheer, Sirin Mneimneh, Mariam Rajab
Rhabdomyolysis is an acute life-threatening condition that can occur in childhood secondary to many causes. The authors report the case of a 3-year-old male child who presented with acute rhabdomyolysis. The peak plasma creatine kinase level was extremely high. The 2 main causes of rhabdomyolysis in childhood are viral myositis and trauma, which can sometimes lead to acute renal failure. The highest creatine kinase levels reported in the literature so far was a 6-digit level in 2014 case report. In this study, the authors report the case of a 7-digit creatine kinase level in a child secondary to viral myositis who did not require renal dialysis...
January 2017: Child Neurol Open
https://www.readbyqxmd.com/read/28500266/n-terminal-thioredoxin-reductase-domains-and-thioredoxins-act-concertedly-in-seedling-development
#7
Valle Ojeda, Juan M Pérez-Ruiz, María-Cruz González, Victoria A Nájera, Mariam Sahrawy, Antonio Jesús Serrato, Peter Geigenberger, Francisco J Cejudo
Thiol-dependent redox regulation of enzyme activity plays a central role in the rapid acclimation of chloroplast metabolism to ever fluctuating light availability. This regulatory mechanism relies on ferredoxin (Fdx) reduced by the photosynthetic electron transport chain, which fuels reducing power to thioredoxins (Trxs) via a Fdx-dependent Trx reductase (FTR). In addition, chloroplasts harbour an NADPH-dependent Trx reductase, which has a joint Trx domain at the C-terminus, termed NTRC. Thus, a relevant issue in chloroplast function is to establish the relationship between these two redox systems and its impact on plant development...
May 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28499281/assortativity-and-mixing-by-sexual-behaviors-and-sociodemographic-characteristics-in-young-adult-heterosexual-dating-partnerships
#8
Talía Malagón, Ann Burchell, Mariam El-Zein, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco
BACKGROUND: Assortative sexual mixing, the tendency for individuals to choose partners with similar characteristics to themselves, may be an important contributor to the unequal distribution of sexually transmitted infections in populations. We analyzed the tendency for assortative mixing on demographic and sexual behaviors characteristics in newly formed young adults dating partnerships. METHODS: Women aged 18 to 24 years and their male sexual partners of no more than 6 months were recruited during 2005 to 2010 at universities in Montreal, Canada...
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28497902/size-shape-and-lateral-correlation-of-highly-uniform-mesoscopic-self-assembled-domains-of-fluorocarbon-hydrocarbon-diblocks-at-the-air-water-interface-a-gisaxs-study
#9
Mariam Veschgini, Wasim Abuillan, Shigeto Inoue, AKihisa Yamamoto, Salomé Mielke, Xianhe Liu, Oleg Konovalov, Marie Pierre Krafft, Motomu Tanaka
The shape and size of self-assembled mesoscopic surface domains of fluorocarbon-hydrocarbon (FnHm) diblocks and the lateral correlation between these domains have been quantitatively determined from grazing incidence small-angle X-ray scattering (GISAXS). The full calculation of structure and form factors unraveled the influence of fluorocarbon and hydrocarbon block lengths on the diameter and height of the domains, and provided the inter-domain correlation length. The diameter of the domains, as determined from the form factor analysis, exhibits a monotonic increase in response to the systematic lengthening of each block, which can be attributed to the increase in van der Waals attraction between molecules...
May 12, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28493802/placental-imaging-normal-appearance-with-review-of-pathologic-findings
#10
Shaimaa Fadl, Mariam Moshiri, Corinne L Fligner, Douglas S Katz, Manjiri Dighe
The placenta plays a crucial role throughout pregnancy, and its importance may be overlooked during routine antenatal imaging evaluation. Detailed systematic assessment of the placenta at ultrasonography (US), the standard imaging examination during pregnancy, is important. Familiarity with the normal and abnormal imaging appearance of the placenta along with the multimodality and methodical approach for evaluation of its related abnormalities is necessary, so that radiologists can alert clinicians regarding appropriate prompt management decisions...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28490285/a-comparative-study-of-short-term-outcomes-of-colorectal-cancer-surgery-in-the-elderly-population
#11
Clarence Yen, Constantinos Simillis, Mariam Choudhry, Sarah Mills, Oliver Warren, Paris P Tekkis, Christos Kontovounisios
BACKGROUND: Colorectal Cancer (CRC) is a disease of the elderly, and with an ageing population, oncological surgical procedures for CRC in the elderly is expected to increase. However, the balance between surgical benefits and risks associated with age and comorbidities in elderly patients is obscure. MATERIALS AND METHODS: A retrospective database of consecutive patients who received CRC surgery was used to compare short-term surgical and oncological outcomes between patients aged ≥75 and <75 years old undergoing CRC resection...
May 11, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28488351/homozygous-microdeletion-of-the-eri1-and-mfhas1-genes-in-a-patient-with-intellectual-disability-limb-abnormalities-and-cardiac-malformation
#12
Nancy Choucair, Mariam Rajab, André Mégarbané, Eliane Chouery
A male child, born from consanguineous parents and having intellectual disability, short stature, dysmorphic facial features, synpolydactyly, and cardiac malformations is reported. Chromosomal microarray analysis showed that the patient presents with an 8p23.1 homozygous deletion, containing the microRNA miR-4660, the exoribonuclease 1 (ERI1), and malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) genes. The microRNA miR-4660 has no known function. MFHAS1 is an immunomodulatory protein involved in Toll-like receptor signaling, erythropoiesis, and cancer...
May 9, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28487436/protective-effect-of-let-7-mirna-family-in-regulating-inflammation-in-diabetes-associated-atherosclerosis
#13
Eoin Brennan, Bo Wang, Aaron McClelland, Muthukumar Mohan, Mariam Marai, Ophelie Beuscart, Sinda Derouiche, Stephen Gray, Raelene Pickering, Chris Tikellis, Monica de Gaetano, Mary Barry, Orina Belton, Syed Tasadaque Ali-Shah, Patrick Guiry, Karin Am Jandeleit-Dahm, Mark E Cooper, Catherine Godson, Phillip Kantharidis
The let-7 miRNA family play a key role in modulating inflammatory responses. Vascular smooth muscle cell (SMC) proliferation, and endothelial cell (EC) dysfunction are critical in the pathogenesis of atherosclerosis, including in the setting of diabetes. Here we report that let-7 levels are decreased in diabetic human carotid plaques and in a model of diabetes-associated atherosclerosis (DAA), the diabetic ApoE(-/-) mouse. In vitro, platelet-derived growth factor (PDGF) and tumor necrosis factor-alpha (TNF-α) induced vascular SMC and EC activation was associated with reduced let-7 miRNA expression, via Lin28b, a negative regulator of let-7 biogenesis...
May 9, 2017: Diabetes
https://www.readbyqxmd.com/read/28487044/regional-variation-in-the-treatment-of-pancreatic-adenocarcinoma-decreasing-disparities-with-multimodality-therapy
#14
Gyulnara G Kasumova, Mariam F Eskander, Susanna W L de Geus, Mario Matiotti Neto, Omidreza Tabatabaie, Sing Chau Ng, Rebecca A Miksad, Anand Mahadevan, James R Rodrigue, Jennifer F Tseng
BACKGROUND: Survival in pancreatic cancer remains poor with curative potential dependent on operative resection. We reviewed national adherence to practice guidelines to evaluate regional variation in the treatment and survival of patients with pancreatic cancer. METHODS: Retrospective cohort review of adults with pancreatic adenocarcinoma using the National Cancer Data Base from 2006 to 2013. Overall survival was compared by the Kaplan-Meier method and Cox proportional hazards models...
May 6, 2017: Surgery
https://www.readbyqxmd.com/read/28485025/adsorptive-granulocyte-monocyte-apheresis-use-in-severe-ulcerative-colitis-and-determination-of-changes-in-plasma-cytokines
#15
Belén Beltrán, Esteban Sáez-González, Inés Moret, Francia C Díaz-Jaime, Diego Alvarez-Sotomayor, Elena Cerrillo, Marisa Iborra, Guillermo Bastida, Mariam Aguas, Pilar Nos
Despite controversy regarding the use of granulocyte/monocyte adsorption (GMA) in inflammatory bowel disease, some studies have shown favorable outcomes when it is used in steroid-dependent patients with ulcerative colitis (UC). The mechanisms responsible for such outcomes are not well characterized, but changes in immune cell populations and cytokine levels have been suggested to play an important role. We report the cases of 3 patients with chronically active severe UC who underwent GMA due to an inadequate response to standard and rescue therapy, as well as changes to their plasma cytokine profile...
May 9, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28477336/rad51-as-a-potential-surrogate-marker-for-dna-repair-capacity-in-solid-malignancies
#16
REVIEW
Mariam Gachechiladze, Josef Škarda, Alex Soltermann, Markus Joerger
Targeting deficient mechanisms of cellular DNA repair still represents the basis for the treatment of the majority of solid tumors, and increased DNA repair capacity is a hallmark mechanism of resistance not only to DNA-damaging treatments such as cytotoxic drugs and radiotherapy, but also to small molecule targeted drugs such as inhibitors of poly-ADP ribose polymerase (PARP). Hence, there is substantial medical need for potent and convenient biomarkers of individual response to DNA-targeted treatment in personalized cancer care...
May 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28476222/pituitary-hypoplasia
#17
REVIEW
Mariam Gangat, Sally Radovick
This article summarizes pituitary development and function as well as specific mutations of genes encoding the following transcription factors: HESX1, LHX3, LHX4, POU1F1, PROP1, and OTX2. Although several additional genetic defects related to hypopituitarism have been identified, this article focuses on these selected factors, as they have been well described in the literature in terms of clinical characterization of affected patients and molecular mechanisms of action, and therefore, are very relevant to clinical practice...
June 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28475618/first-time-detection-and-identification-of-the-mycobacterium-tuberculosis-complex-members-in-extrapulmonary-tuberculosis-clinical-samples-in-south-tunisia-by-a-single-tube-tetraplex-real-time-pcr-assay
#18
Mariam Siala, Salma Smaoui, Wafa Taktak, Salma Hachicha, Asma Ghorbel, Chema Marouane, Sana Kammoun, Dhikrayet Gamara, Leila Slim, Radhouane Gdoura, Férièle Messadi-Akrout
INTRODUCTION: Tunisia has one of the highest burdens of extrapulmonary tuberculosis (EPTB) among tuberculosis (TB) cases but the contribution of MTBC-mediated human EPTB is unknown. EPTB diagnosis is challenging due to the paucibacillary nature of clinical samples. Therefore, a need of a simplified molecular method for sensitive and specific TB detection and differentiation of MTBC members caused EPTB remains a priority to an early diagnosis, optimize successful anti-TB treatment and minimize transmission...
May 5, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28475249/primary-chylous-vaginal-discharge-demonstrated-with-noncontrast-magnetic-resonance-lymphography
#19
Mariam Soumah, Sanaâ El Mouhadi, Corinne Becker, Lionel Arrivé
Primary chylous vaginal discharge is rare. It can be associated with lower limb, pelvic, or vulvar lymphedema or cutaneous vesicles in the perineum, labia, or legs. An analysis of vaginal discharge is helpful to reveal milky fluid with chylomicrons and a triglyceride rate greater than 11 mL/L [1]. In the present case, chylous vaginal discharge was due to a hyperplasia-dysplasia of lymphatics in the pelvis abutting the uterus, cervix, and vagina. This article is protected by copyright. All rights reserved.
May 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28472969/perforated-acute-appendicitis-with-no-peritonitis-in-a-premature-baby-a-case-report
#20
Fayza Haider, Barrak Ayoub, Mariam Al Kooheji, Mona Al Juffairi, Safa Al-Shaikh
BACKGROUND: Acute appendicitis in a neonate and premature baby is still considered a rare entity as diagnosis is always made after surgical exploration for acute abdominal findings mimicking necrotizing enterocolitis. Our reported case is a premature baby who had a perforated appendix with no evidence of peritonitis. CASE PRESENTATION: We describe the case of a premature Bahraini girl born at 29 weeks of gestation by spontaneous vaginal delivery to a 39-year-old G6P5 mother...
May 5, 2017: Journal of Medical Case Reports
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