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https://www.readbyqxmd.com/read/28732040/perceptions-of-arab-men-regarding-female-breast-cancer-screening-examinations-findings-from-a-middle-east-study
#1
Tam Truong Donnelly, Al-Hareth Al-Khater, Salha Bujassoum Al-Bader, Mohamed Ghaith Al-Kuwari, Mariam Ali Abdul Malik, Nabila Al-Meer, Rajvir Singh
OBJECTIVES: In the Middle East, Qatar in particular, the incidence of breast cancer has substantially increased in recent years, and is expected to double by 2030. This diagnosis also occurs at a later stage in the disease. Early detection along with proper treatment reduces radical mastectomy and mortality rates, yet only one-third of Arab women in Qatar participate in breast cancer screening (BCS) activities of any sort. Many women in the conservative Qatari society rely on male family members for support and protection...
2017: PloS One
https://www.readbyqxmd.com/read/28728597/interaction-of-direct-and-social-genetic-effects-with-feeding-regime-in-growing-rabbits
#2
Miriam Piles, Ingrid David, Josep Ramon, Laurianne Canario, Oriol Rafel, Mariam Pascual, Mohamed Ragab, Juan P Sánchez
BACKGROUND: Most rabbit production farms apply feed restriction at fattening because of its protective effect against digestive diseases that affect growing rabbits. However, it leads to competitive behaviour between cage mates, which is not observed when animals are fed ad libitum. Our aim was to estimate the contribution of direct ([Formula: see text]) and social ([Formula: see text]) genetic effects (also known as indirect genetic effects) to total heritable variance of average daily gain ([Formula: see text]) in rabbits on different feeding regimens (FR), and the magnitude of the interaction between genotype and FR (G × FR)...
July 20, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28724472/appraisal-of-the-preparedness-of-midwives-and-nurses-in-bahrain-to-conduct-early-screening-for-zika-virus-infection-in-pregnant-women
#3
Asokan G V, Mariam Mohammed Baqer Nama, Feryal Juma Salman, Zainab Habib Ali AlGhareeb, Ali Moosa Almoosawi, Ridha Abdulla Al Hammam, Muyssar Sabri Awadhalla
OBJECTIVE: To appraise the awareness and knowledge levels of midwives and nurses concerning early screening for Zika virus (ZIKV) infection among pregnant women attending health care facilities in Bahrain. METHODS: This was a cross-sectional, purposely chosen study of Bahraini and expatriate midwives, nurses, and supervisors employed in gynecology/obstetrics and labor wards of Salmanya hospital, a maternity hospital, 4 private hospitals, and health centers in Bahrain...
July 20, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28719003/mutation-intolerant-genes-and-targets-of-fmrp-are-enriched-for-nonsynonymous-alleles-in-schizophrenia
#4
Ganna Leonenko, Alexander L Richards, James T Walters, Andrew Pocklington, Kimberly Chambert, Mariam M Al Eissa, Sally I Sharp, Niamh L O'Brien, David Curtis, Nicholas J Bass, Andrew McQuillin, Christina Hultman, Jennifer L Moran, Steven A McCarroll, Pamela Sklar, Benjamin M Neale, Peter A Holmans, Michael J Owen, Patrick F Sullivan, Michael C O'Donovan
Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous studies have suggested that some of the risk of schizophrenia is attributable to uncommon alleles represented on Illumina exome arrays. Here, we present the largest study of exomic variation in schizophrenia to date, using samples from the United Kingdom and Sweden (10,011 schizophrenia cases and 13,791 controls)...
July 18, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28718838/phyllanthus-niruri-standardized-extract-alleviates-the-progression-of-non-alcoholic-fatty-liver-disease-and-decreases-atherosclerotic-risk-in-sprague-dawley-rats
#5
Raghdaa Hamdan Al Zarzour, Mariam Ahmad, Mohd Zaini Asmawi, Gurjeet Kaur, Mohammed Ali Ahmed Saeed, Majed Ahmed Al-Mansoub, Sultan Ayesh Mohammed Saghir, Nasiba Salisu Usman, Dhamraa W Al-Dulaimi, Mun Fei Yam
Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different extracts of Phyllanthus niruri (P. niruri). NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28718257/risk-factors-for-heat-related-deaths-during-the-june-2015-heat-wave-in-karachi-pakistan
#6
Syed Ghazanfar Saleem, Tehreem Ansari, Ashraf Shamshad Ali, Sara Fatima, Mariam Hassan Rizvi, Muhammad Abdul Samad
BACKGROUND: Mortality as a consequence of heat related illness is a public health concern. Emergency department (ED) experiences increased patients' flow and decreased survival as a consequence of heat stroke during the episodes of heat wave. The present study was conducted to identify the risk factors for mortality among victims of heat wave (17th - 23rd June), 2015 evaluated in the Emergency Department of The Indus Hospital (TIH), Karachi. METHODS: In this cross-sectional study data was retrospectively collected...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28715912/acetyl-and-o-alkyl-derivatives-of-%C3%AE-mangostin-from-garcinia-mangostana-and-their-anti-inflammatory-activities
#7
Thiruventhan Karunakaran, Gwendoline Cheng Lian Ee, Intan Safinar Ismail, Siti Mariam Mohd Nor, Nor Hisam Zamakshshari
Pure β-mangostin (1) was isolated from the stem bark of Garcinia mangostana L. One monoacetate (2) and five O-alkylated β-mangostin derivatives (3-7) were synthesised from β-mangostin. The structures of these compounds were elucidated and determined using spectroscopic techniques such as 1D NMR and MS. The cytotoxicities and anti-inflammatory activities of these five compounds against RAW cell 264.7 were tested. The structural-activity relationship studies indicated that β-mangostin showed a significant activity against the LPS-induced RAW cell 264...
July 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28715131/transcriptome-analysis-suggests-a-role-for-the-differential-expression-of-cerebral-aquaporins-and-the-mapk-signalling-pathway-in-human-temporal-lobe-epilepsy
#8
Mootaz M Salman, Mariam A Sheilabi, Dev Bhattacharyya, Philip Kitchen, Alex C Conner, Roslyn M Bill, M Nicola Woodroofe, Matthew T Conner, Alessandra P Princivalle
Epilepsies are common disorders of the central nervous system (CNS), affecting up to 2% of the global population. Pharmaco-resistance is a major clinical challenge affecting about 30% of temporal lobe epilepsy (TLE) patients. Water homeostasis has been shown crucial for regulation of neuronal excitability. The control of water movement is achieved through a family of small integral membrane channel proteins called aquaporins (AQPs). Despite the fact that changes in water homeostasis occur in sclerotic hippocampi of people with TLE, the expression of AQPs in the epileptic brain is not fully characterised...
July 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28714771/acute-effect-of-static-stretching-on-lower-limb-movement-performance-by-using-stabl-virtual-reality-system
#9
Mariam A Ameer, Qassim I Muaidi
CONTEXT: The effect of acute static stretch (ASS) on the lower limb RT has been recently questioned to decrease the risk of falling and injuries in situations requiring a rapid reaction, as in the cases of balance disturbance. OBJECTIVE: The main purpose of this study was to detect the effect of ASS on the lower limb RT by using virtual reality device. DESIGN: Two Group Control Group design. SETTING: Research laboratory...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28711268/short-communication-implementation-of-a-breeding-value-for-heat-tolerance-in-australian-dairy-cattle
#10
Thuy T T Nguyen, Phil J Bowman, Mekonnen Haile-Mariam, Gert J Nieuwhof, Benjamin J Hayes, Jennie E Pryce
Excessive ambient temperature and humidity can impair milk production and fertility of dairy cows. Selection for heat-tolerant animals is one possible option to mitigate the effects of heat stress. To enable selection for this trait, we describe the development of a heat tolerance breeding value for Australian dairy cattle. We estimated the direct genomic values of decline in milk, fat, and protein yield per unit increase of temperature-humidity index (THI) using 46,726 single nucleotide polymorphisms and a reference population of 2,236 sires and 11,853 cows for Holsteins and 506 sires and 4,268 cows for Jerseys...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28709950/characterization-of-potent-and-selective-iodonium-class-inhibitors-of-nadph-oxidases
#11
Jiamo Lu, Prabhakar Risbood, Charles T Kane, Md Tafazzal Hossain, Larry Anderson, Kimberly Hill, Anne Monks, Yongzhong Wu, Smitha Antony, Agnes Juhasz, Han Liu, Guojian Jiang, Erik Harris, Krishnendu Roy, Jennifer L Meitzler, Mariam Konaté, James H Doroshow
The NADPH oxidases (NOXs) play a recognized role in the development and progression of inflammation-associated disorders, as well as cancer. To date, several NOX inhibitors have been developed, through either high throughput screening or targeted disruption of NOX interaction partners, although only a few have reached clinical trials. To improve the efficacy and bioavailability of the iodonium class NOX inhibitor diphenylene iodonium (DPI), we synthesized 36 analogs of DPI, focusing on improved solubility and functionalization...
July 11, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28708929/stereotactic-body-radiotherapy-for-unresected-pancreatic-cancer-a-nationwide-review
#12
Susanna W L de Geus, Mariam F Eskander, Gyulnara G Kasumova, Sing Chau Ng, Tara S Kent, Joseph D Mancias, Mark P Callery, Anand Mahadevan, Jennifer F Tseng
BACKGROUND: The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer. METHODS: The National Cancer Data Base was queried for unresected patients who received chemotherapy for nonmetastatic pancreatic adenocarcinoma between 2004 and 2012...
July 14, 2017: Cancer
https://www.readbyqxmd.com/read/28708805/serum-adalimumab-levels-predict-successful-remission-and-safe-deintensification-in-inflammatory-bowel-disease-patients-in-clinical-practice
#13
Mariam Aguas Peris, Virginia Bosó, Belén Navarro, Maria R Marqués-Miñana, Guillermo Bastida, Belén Beltrán, Marisa Iborra, Esteban Sáez-González, Emilio Monte-Boquet, Jose L Poveda-Andrés, Pilar Nos
BACKGROUND: Little is known about the association between the pharmacokinetic features of adalimumab (ADL) and disease outcome in patients with inflammatory bowel disease (IBD). AIMS: To assess the association between random serum ADL levels and clinical or biochemical remission with clinical decision making in daily practice according to these levels; and to determine the cutoff value for successful dose reduction in patients with IBD treated with ADL. METHODS: We conducted a prospective observational study of patients with IBD who received long-term maintenance therapy with ADL...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28706763/comparison-of-knowledge-attitudes-and-practices-of-educated-and-uneducated-adults-regarding-human-immunodeficiency-virus-in-karachi-pakistan
#14
Zainab Ahmad, Sara Sadiq, Mariam Asghar, Alizay Rashid Khan, Omer Arif, Syed Hamza Shah, Shahrukh Nadeem, Yamna Waseem, Rafi Aibani, Ammar Salman Syed, Rabia M Mustafa, Zainab Abdulrahman, Kaneez Fatima
BACKGROUND: Despite the high prevalence of human immunodeficiency virus (HIV) in Pakistan, no prior work has been done to specifically highlight the importance of education as a social vaccine against HIV. Therefore, our study focuses on differences in knowledge and practices regarding HIV and acquired immunodeficiency syndrome (AIDS) among educated and uneducated adults. METHODOLOGY: A cross-sectional study was carried out in which data was collected from all over Karachi...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28705514/bacillus-calmette-gu%C3%A3-rin-bcg-vaccination-patterns-in-the-province-of-qu%C3%A3-bec-canada-1956-1974
#15
Marie-Claude Rousseau, Florence Conus, Khady Kâ, Mariam El-Zein, Marie-Élise Parent, Dick Menzies
BACKGROUND: In the province of Québec, Canada, the Bacillus Calmette-Guérin (BCG) vaccine was offered to newborns and school-age children from the 1950s to mid-1970s in an organized tuberculosis prevention program. OBJECTIVE: We aimed to describe the annual rates of skin test administration, proportion of skin tests that were positive, and rates of BCG vaccination from 1956 to 1974 according to age, sex, and administrative region. METHODS: For rates, numerators were extracted from the Québec BCG Vaccination Registry whereas population denominators were obtained from the Canadian Census and governmental publications...
July 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28705053/cardiac-amyloidosis-pathogenesis-clinical-context-diagnosis-and-management-options
#16
Hassan Alkhawam, Darshan Patel, James Nguyen, Saumya Mariam Easaw, Mohammed Al-Sadawi, Umer Syed, Feras Zaiem, Maher Homsi, Timothy J Vittorio
Amyloidosis covers a group of disorders that can manifest in virtually any organ system in the body and is thought to be secondary to misfolding of extracellular proteins with subsequent deposition in tissues. The precursor protein that is produced in excess defines the specific amyloid type. This requires histopathological confirmation using Congo-red dye with its characteristic demonstration of green birefringence under cross-polarized light. There are three main types of amyloidosis associated with cardiac involvement: light-chain (AL), familial or senile (ATTR), and secondary (AA) amyloidosis...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28704565/contribution-of-seagrass-plants-to-co2-capture-in-a-tropical-seagrass-meadow-under-experimental-disturbance
#17
Diana Deyanova, Martin Gullström, Liberatus D Lyimo, Martin Dahl, Mariam I Hamisi, Matern S P Mtolera, Mats Björk
Coastal vegetative habitats are known to be highly productive environments with a high ability to capture and store carbon. During disturbance this important function could be compromised as plant photosynthetic capacity, biomass, and/or growth are reduced. To evaluate effects of disturbance on CO2 capture in plants we performed a five-month manipulative experiment in a tropical seagrass (Thalassia hemprichii) meadow exposed to two intensity levels of shading and simulated grazing. We assessed CO2 capture potential (as net CO2 fixation) using areal productivity calculated from continuous measurements of diel photosynthetic rates, and estimates of plant morphology, biomass and productivity/respiration (P/R) ratios (from the literature)...
2017: PloS One
https://www.readbyqxmd.com/read/28701289/chronic-pm2-5-exposure-and-risk-of-infant-bronchiolitis-and-otitis-media-clinical-encounters
#18
Mariam S Girguis, Matthew J Strickland, Xuefei Hu, Yang Liu, Howard H Chang, Candice Belanoff, Scott M Bartell, Verónica M Vieira
Chronic particulate matter less than 2.5μm in diameter (PM2.5) exposure can leave infants more susceptible to illness. Our objective is to estimate associations of the chronic PM2.5 exposure with infant bronchiolitis and otitis media (OM) clinical encounters. We obtained all first time bronchiolitis (n=18,029) and OM (n=40,042) clinical encounters among children less than 12 and 36 months of age, respectively, diagnosed from 2001 to 2009 and two controls per case matched on birthdate and gestational age from the Pregnancy to Early Life Longitudinal data linkage system in Massachusetts...
July 1, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28697888/regulated-expansion-and-survival-of-chimeric-antigen-receptor-modified-t-cells-using-small-molecule-dependent-inducible-myd88-cd40
#19
Aaron E Foster, Aruna Mahendravada, Nicholas P Shinners, Wei-Chun Chang, Jeannette Crisostomo, An Lu, Mariam Khalil, Eva Morschl, Joanne L Shaw, Sunandan Saha, MyLinh T Duong, Matthew R Collinson-Pautz, David L Torres, Tania Rodriguez, Tsvetelina Pentcheva-Hoang, J Henri Bayle, Kevin M Slawin, David M Spencer
Anti-tumor efficacy of T cells engineered to express chimeric antigen receptors (CARs) is dependent on their specificity, survival, and in vivo expansion following adoptive transfer. Toll-like receptor (TLR) and CD40 signaling in T cells can improve persistence and drive proliferation of antigen-specific CD4(+) and CD8(+) T cells following pathogen challenge or in graft-versus-host disease (GvHD) settings, suggesting that these costimulatory pathways may be co-opted to improve CAR-T cell persistence and function...
July 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28693732/wheat-germ-agglutinin-and-lens-culinaris-agglutinin-sensitized-anisotropic-silver-nanoparticles-in-detection-of-bacteria-a-simple-photometric-assay
#20
Mariam V Mikaelyan, Gayane G Poghosyan, Olga D Hendrickson, Boris B Dzantiev, Vardan K Gasparyan
Efficacy of anisotropic silver nanoparticles sensitized with wheat germ agglutinin (WGA) and Lens culinaris agglutinin (LCA) was studied for detection of Staphylococcus aureus and Escherichia coli. It was demonstrated that interaction of these nanoparticles with bacteria stabilizes them and prevents their aggregation upon addition of sodium chloride; such stabilization depends on bacteria concentration. High concentration of bacteria results in higher stabilization whereas low concentration leads to aggregation of nanoparticles...
August 15, 2017: Analytica Chimica Acta
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