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https://www.readbyqxmd.com/read/28430777/correction-the-subclonal-architecture-of-metastatic-breast-cancer-results-from-a-prospective-community-based-rapid-autopsy-program-cascade
#1
Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi
[This corrects the article DOI: 10.1371/journal.pmed.1002204.].
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28427628/ultrasonic-energy-enhanced-the-efficiency-of-advance-extraction-methodology-for-enrichment-of-trace-level-of-copper-in-serum-samples-of-patients-having-neurological-disorders
#2
Mariam S Arain, Tasneem G Kazi, Hassan I Afridi, Jamshed Ali, Asma Akhtar
An innovative dual dispersive ionic liquid based on ultrasound assisted microextraction (UDIL-μE), for the enrichment of trace levels of copper ion (Cu(2+)), in serum (blood) of patients suffering from different neurological disorders. The enriched metal ions were subjected to flame atomic absorption spectrometry (FAAS). In the UDIL-μE method, the extraction solvent, ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate [C4mim][PF6], was dispersed into the aqueous samples using an ultrasonic bath...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427409/efficacies-of-dha-ppq-and-as-sp-in-patients-with-uncomplicated-plasmodium-falciparum-malaria-in-an-area-of-an-unstable-seasonal-transmission-in-sudan
#3
Abdelrahim O Mohamed, Muzamil M Abdel Hamid, Omer S Mohamed, Nuha S Elkando, Abdelmaroof Suliman, Mariam A Adam, Fahad Awad Ali Elnour, Elfatih M Malik
BACKGROUND: Artemisinin-based combination therapy (ACT), together with other control measures, have reduced the burden of falciparum malaria in sub-Saharan countries, including Sudan. Sudan adopted ACT in 2004 with a remarkable reduction in mortality due to falciparum malaria. However, emergence of resistance to the first-line treatment artesunate and sulfadoxine/pyrimethamine (AS/SP) has created new challenges to the control of malaria in Sudan. A search for an alternative drug of choice for treating uncomplicated malaria has become inevitable...
April 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28421983/comparative-study-between-multivariate-and-univariate-analysis-of-two-antidiabetic-combinations
#4
Maha F Abdel-Ghany, Omar Abdel-Aziz, Miriam F Ayad, Mariam M Tadros
New multivariate and univariate methods were developed for the analysis of two novel gliptin combinations by manipulating the zero-order and ratio spectra of empagliflozin and linagliptin in combination, with application on Glyxambi(®) tablets, and of alogliptin and pioglitazone in combination, with application on Oseni(®) tablets. Linearity ranges for chemometric approaches using principal component regression and partial least-squares were found to be 2–10, 2.5–12.5, 5–15, and 5–25 μg/mL for empagliflozin, linagliptin, alogliptin, and pioglitazone, respectively, whereas the respective linearity ranges for the spectrophotometric approaches were found to be 5–15, 2–12, 5–15, and 5–15 μg/mL...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28420937/rise-and-stalling-of-public-health-in-pakistan
#5
Inayat Thaver, Mariam Ashraf
No abstract text is available yet for this article.
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28420680/use-of-azithromycin-and-risk-of-ventricular-arrhythmia
#6
Gianluca Trifirò, Maria de Ridder, Janet Sultana, Alessandro Oteri, Peter Rijnbeek, Serena Pecchioli, Giampiero Mazzaglia, Irene Bezemer, Edeltraut Garbe, Tania Schink, Elisabetta Poluzzi, Trine Frøslev, Mariam Molokhia, Igor Diemberger, Miriam C J M Sturkenboom
BACKGROUND: There are conflicting findings from observational studies of the arrhythrogenic potential of azithromycin. Our aim was to quantify the association between azithromycin use and the risk of ventricular arrhythmia. METHODS: We conducted a nested case-control study within a cohort of new antibiotic users identified from a network of 7 population-based health care databases in Denmark, Germany, Italy, the Netherlands and the United Kingdom for the period 1997-2010...
April 18, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28418827/case-245
#7
Mark D Mamlouk, Mariam S Aboian, Christine M Glastonbury
No abstract text is available yet for this article.
May 2017: Radiology
https://www.readbyqxmd.com/read/28416369/plasma-levels-of-apolipoprotein-a1-and-lecithin-cholesterol-acyltransferase-in-type-2-diabetes-mellitus-correlations-with-haptoglobin-phenotypes
#8
Samir Awadallah, Mohammed Madkour, Reem Al Hamidi, Esraa Abo Alwafa, Maram Hattab, Buhour Zakkour, Amna Al-Matroushi, Eslah Ahmed, Mariam Al-Kitbi
BACKGROUND: Previous studies have demonstrated that hemoglobin-haptoglobin (Hb-Hp) complex plays a role in developing vascular complications in type 2 diabetes mellitus (T2DM). The complexes bind with Apolipoprotein A1 (ApoA1) of high-density lipoprotein (HDL), affecting the function of Lecithin:Cholesterol Acyltransferase (LCAT), and impairing the reverse cholesterol transport mechanism (RCT). This study investigated the influence of Hp phenotypes on serum levels of ApoA1 and LCAT in patients with T2DM...
April 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28415677/selective-elimination-of-long-interspersed-element-1-expressing-tumour-cells-by-targeted-expression-of-the-hsv-tk-suicide-gene
#9
Mariam Chendeb, Robert Schneider, Irwin Davidson, Anas Fadloun
In gene therapy, effective and selective suicide gene expression is crucial. We exploited the endogenous Long INterspersed Element-1 (L1) machinery often reactivated in human cancers to integrate the Herpes Simplex Virus Thymidine Kinase (HSV-TK) suicide gene selectively into the genome of cancer cells. We developed a plasmid-based system directing HSV-TK expression only when reverse transcribed and integrated in the host genome via the endogenous L1 ORF1/2 proteins and an Alu element. Delivery of these new constructs into cells followed by Ganciclovir (GCV) treatment selectively induced mortality of L1 ORF1/2 protein expressing cancer cells, but had no effect on primary cells that do not express L1 ORF1/2...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414292/dendritic-cells-expressing-immunoreceptor-cd300f-are-critical-for-controlling-chronic-gut-inflammation
#10
Ha-Na Lee, Linjie Tian, Nicolas Bouladoux, Jacquice Davis, Mariam Quinones, Yasmine Belkaid, John E Coligan, Konrad Krzewski
Proinflammatory cytokine overproduction and excessive cell death, coupled with impaired clearance of apoptotic cells, have been implicated as causes of failure to resolve gut inflammation in inflammatory bowel diseases. Here we have found that dendritic cells expressing the apoptotic cell-recognizing receptor CD300f play a crucial role in regulating gut inflammatory responses in a murine model of colonic inflammation. CD300f-deficient mice failed to resolve dextran sulfate sodium-induced colonic inflammation as a result of defects in dendritic cell function that were associated with abnormal accumulation of apoptotic cells in the gut...
April 17, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28413735/a-survey-of-handwashing-knowledge-and-attitudes-among-the-healthcare-professionals-in-lahore-pakistan
#11
Ahsan Zil-E-Ali, Mohsin A Cheema, Muhammad Wajih Ullah, Hamzah Ghulam, Mariam Tariq
OBJECTIVE: To evaluate the knowledge and attitudes towards handwashing of clinical year medical and dental students and health-care professionals (HCPs) working in the departments of medicine, surgery, dentistry, nursing, and physiotherapy in Lahore, Pakistan. METHODOLOGY: This was a cross-sectional survey conducted during May and June 2016. After approval from the institutional review board, a modified form of the World Health Organization (WHO) Hand Hygiene Knowledge Questionnaire for Healthcare workers that included 18 items was sent to 400 clinical year students and HCPs from six medical colleges and affiliated hospitals of Lahore...
March 9, 2017: Curēus
https://www.readbyqxmd.com/read/28412465/authors-of-clinical-trials-reported-individual-and-financial-conflicts-of-interest-more-frequently-than-institutional-and-non-financial-ones-a-methodological-survey
#12
Maram B Hakoum, Nahla Jouni, Eliane A Abou-Jaoude, Divina Justina Hasbani, Elias A Abou-Jaoude, Luciane Cruz Lopes, Mariam Khaldieh, Mira Z Hammoud, Mounir Al Gibbawi, Sirine Anouti, Gordon Guyatt, Elie A Akl
BACKGROUND: Conflicts of interest (COI) are increasingly recognised as important to disclose and manage in health research. The objective of this study was to assess the reporting of both financial and non-financial COI by authors of randomised controlled trials published in a representative sample of clinical journals. METHODS: We searched Ovid Medline and included a random sample of 200 randomised controlled trials published in 2015 in one of the 119 Core Clinical Journals...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28412326/no-acute-changes-in-lvef-observed-with-concurrent-trastuzumab-and-breast-radiation-with-low-heart-doses
#13
Shelly X Bian, Mariam P Korah, Taylor R Whitaker, Lingyun Ji, Susan Groshen, Eugene Chung
INTRODUCTION/BACKGROUND: Treatment for HER2-postitive breast cancer often includes trastuzumab, breast/chest wall (CW) radiation (RT), and anthracyclines, all of which have cardiac toxicity. We aimed to evaluate the relationship between heart dose and acute left ventricular ejection fraction (LVEF) changes in patients who received concurrent trastuzumab and breast/CW RT with and without anthracycline use. PATIENTS AND METHODS: We retrospectively reviewed all nonmetastatic breast cancer patients from 2008 to 2015 who received concurrent trastuzumab and breast/CW RT...
March 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28408668/genome-sequence-of-cobetia-sp-strain-mm1ida2h-1-a-hydrocarbon-degrading-and-biosurfactant-producing-marine-bacterium
#14
Claudia Ibacache-Quiroga, Christian Canales, Mariam Charifeh, M Alejandro Dinamarca
Cobetia sp. strain MM1IDA2H-1 is a marine bacterium isolated from seawater samples that uses the heterocyclic aromatic hydrocarbon dibenzothiophene as the sole carbon source and produces a biosurfactant that inhibits bacterial quorum sensing. The Cobetia sp. MM1IDA2H-1 genome was sequenced, processed, assembled, and annotated for basic and applied studies.
April 13, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28407621/potential-applications-of-phyto-derived-ceramides-in-improving-epidermal-barrier-function
#15
Efrem N Tessema, Tsige Gebre-Mariam, Reinhard H H Neubert, Johannes Wohlrab
The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated...
April 14, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28401036/anomalous-origin-of-the-left-pulmonary-artery-hemi-truncus-arteriosus
#16
Ali Shabbir Hussain, Mariam Shakir, Shabina Ariff, Rehan Ali, Babar Hassan
Hemi-truncus arteriosus is a rare congenital cardiovascular malformation. It usually presents in infancy and leads to development of progressive pulmonary vascular disease, heart failure, and death. We report a case of hemi truncus arteriosus in a 12-day-old neonate who was successfully managed at our institute.
March 2017: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/28396652/using-routine-hemoglobin-a1c-testing-to-determine-the-glycemic-status-in-psychiatric-inpatients
#17
Pratyusha Naidu, Leonid Churilov, Alvin Kong, Richard Kanaan, Henry Wong, Arielle Van Mourik, Anthony Yao, Elizabeth Cornish, Mariam Hachem, Graeme K Hart, Elizabeth Owen-Jones, Raymond Robbins, Que Lam, Katherine Samaras, Jeffrey D Zajac, Elif I Ekinci
AIM: Using routine hemoglobin A1c (HbA1c) testing to describe the prevalence, characteristics, and length of stay (LOS) of psychiatry inpatients with type 2 diabetes compared to those with pre-diabetes and those without diabetes. METHODS: In this prospective observational study, all inpatients aged greater than 30 years admitted to the Austin Health Psychiatry Unit, a major tertiary hospital, affiliated with the University of Melbourne, between February 2014 and April 2015 had routine HbA1c testing as part of the Diabetes Discovery Initiative...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28394160/free-recall-test-experience-potentiates-strategy-driven-effects-of-value-on-memory
#18
Michael S Cohen, Jesse Rissman, Mariam Hovhannisyan, Alan D Castel, Barbara J Knowlton
People tend to show better memory for information that is deemed valuable or important. By one mechanism, individuals selectively engage deeper, semantic encoding strategies for high value items (Cohen, Rissman, Suthana, Castel, & Knowlton, 2014). By another mechanism, information paired with value or reward is automatically strengthened in memory via dopaminergic projections from midbrain to hippocampus (Shohamy & Adcock, 2010). We hypothesized that the latter mechanism would primarily enhance recollection-based memory, while the former mechanism would strengthen both recollection and familiarity...
April 10, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28391464/processed-milk-waste-recycling-via-thermal-pretreatment-and-lactic-acid-bacteria-fermentation
#19
Mariam Kasmi, Moktar Hamdi, Ismail Trabelsi
Processed milk waste (MW) presents a serious problem within the dairy industries due to its high polluting load. Its chemical oxygen demand (COD) can reach values as high as 80,000 mg O2 L(-1). This study proposes to reduce the organic load of those wastes using thermal coagulation and recover residual valuable components via fermentation. Thermal process results showed that the COD removal rates exceeded 40% when samples were treated at temperature above 60 °C to reach 72% at 100 °C. Clarified supernatants resulting from thermal treatment of the samples at the temperatures of 60 (MW60), 80 (MW80), and 100 °C (MW100) were fermented using lactic acid bacteria strains without pH control...
April 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28378903/building-capability-for-clinical-pharmacology-research-in-sub-saharan-africa
#20
REVIEW
Marcelo M Gutierrez, Goonaseelan Colin Pillai, Sandra Felix, Fernando Romero, Kevin Omondi Onyango, Seth Owusu-Agyei, Kwaku Poku Asante, Karen I Barnes, Phumla Sinxadi, Elizabeth Allen, Salim Abdulla, Collen Masimirembwa, Michelle Munyoro, Getnet Yimer, Tsige Gebre-Mariam, Jonathan Spector, Bernhards Ogutu
No abstract text is available yet for this article.
April 5, 2017: Clinical Pharmacology and Therapeutics
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