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https://www.readbyqxmd.com/read/29777370/analysis-of-genetic-variability-of-respiratory-syncytial-virus-groups-a-and-b-in-kuwait
#1
Nada Madi, Wassim Chehadeh, Mohammed Asadzadeh, Mariam Al-Turab, Anfal Al-Adwani
Respiratory syncytial virus (RSV) is the most frequently identified viral agent in infants, children, and elderly people with acute respiratory tract infections (ARTIs). This study is the only one of its kind in Kuwait, and its purpose was to investigate the genetic variability of the G protein gene in RSV strains prevalent in Kuwait. Respiratory samples were collected from patients with ARTIs in various hospitals in Kuwait and subjected to reverse transcription PCR (RT-PCR) amplifying a fragment of the G gene of RSV...
May 19, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29773528/a-digital-app-to-aid-detection-monitoring-and-management-of-dyslexia-in-young-children-dimmand-protocol-for-a-digital-health-and-education-solution
#2
Mariam R Sood, Annet Toornstra, Martin I Sereno, Mark Boland, Daniele Filaretti, Anuj Sood
BACKGROUND: Dyslexia, a specific learning difficulty and a disability as defined in the Equality Act 2010, is a lifelong condition that affects a child from the start of education. Dyslexia is characterized by difficulties in language processing (reading, spelling, and writing) which do not correspond with the child's general intellectual abilities. Although dyslexia cannot be cured, there is a consensus that interventions are more effective and have greater impact the earlier they are administered...
May 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29763573/a-cross-sectional-assessment-of-rhinitis-symptoms-and-nasal-patency-in-relation-to-welding-exposure
#3
Mahsa Taghiakbari, Roberto Castano, Alfi Afadiyanti Parfi, Meshack Achore, Mariam El-Zein, Mounia Senhaji Rhazi, Denyse Gautrin, Eva Suarthana
No abstract text is available yet for this article.
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29761134/mild-cognitive-impairment-in-republic-of-georgia
#4
Marina Janelidze, Nina Mikeladze, Nazibrola Bochorishvili, Ann Dzagnidze, Mariam Kapianidze, Nino Mikava, Irene Khatiashvili, Ekaterina Mirvelashvili, Nino Shiukashvili, John Lynch, Zurab Nadareishvili
Objective: The goal of this study was to estimate the prevalence of mild cognitive impairment (MCI) in Georgia. Method: A population-based study was conducted using Georgian version of the Montreal Cognitive Assessment (MoCA) and its cognitive domain index score. Results: Of the initial cohort of 1,000 subjects, 851 met inclusion criteria. The prevalence of MCI was 13.3%, and it was associated with age >65 years (odds ratio [OR] = 4.51, 95% confidence interval [CI] = [3.00, 6.75]), urban residence (OR = 0...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29748799/metal-contamination-in-quail-meat-residues-sources-molecular-biomarkers-and-human-health-risk-assessment
#5
Wageh Sobhy Darwish, Amira Samir Atia, Mariam H E Khedr, Walaa Fathy Saad Eldin
Quail meat is an emerging source of high-quality animal protein. Quails are exposed to a wide range of xenobiotics such as heavy metals. In this study, residual concentrations of four toxic metals, of significant public health importance, including cadmium (Cd), lead (Pb), arsenic (As), and nickel (Ni), were determined in edible tissues of quails. In addition, metal loads were measured in water, feed, and litter samples collected from same quail farms as possible sources for quail exposure to heavy metals. The possible use of metallothionein (MT) and heat shock protein 70 (Hsp70) as molecular biomarkers of exposure to heavy metals was further investigated...
May 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29747212/association-between-insulin-resistance-and-cardiovascular-risk-factors-in-polycystic-ovary-syndrome-patients
#6
Miriam da Silva Wanderley, Lara Cristina Ribeiro Pereira, Carla Borges Santos, Vinícius Santos da Cunha, Mariam Viviane Jovino Neves
OBJECTIVE:  To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. METHODS:  Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29737023/liquid-chromatographic-and-spectrofluorimetric-assays-of-empagliflozin-applied-to-degradation-kinetic-study-and-content-uniformity-testing
#7
Maha F Abdel-Ghany, Miriam F Ayad, Mariam M Tadros
Stability-indicating high-performance liquid chromatography (HPLC) and spectrofluorimetric methods were developed for determination of empagliflozin (EGF). EGF was subjected to oxidation, wet heat, photo-degradation, acid hydrolysis and alkali hydrolysis. The alkaline degradation pathway was subjected to a kinetics study as the major product obtained after stress conditions. Arrhenius plots were constructed and the activation energies of the degradation process were calculated. HPLC was used for the kinetic study as it enabled simultaneous determination of EGF and the degradation product while the spectrofluorimetric assay was applied to content uniformity testing due to its higher sensitivity and lower limit of detection (LOD)...
May 7, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29732738/starvation-tactics-using-natural-compounds-for-advanced-cancers-pharmacodynamics-clinical-efficacy-and-predictive-biomarkers
#8
REVIEW
Khalid El Bairi, Mariam Amrani, Said Afqir
The high mortality associated with oncological diseases is mostly due to tumors in advanced stages, and their management is a major challenge in modern oncology. Angiogenesis is a defined hallmark of cancer and predisposes to metastatic invasion and dissemination and is therefore an important druggable target for cancer drug discovery. Recently, because of drug resistance and poor prognosis, new anticancer drugs from natural sources targeting tumor vessels have attracted more attention and have been used in several randomized and controlled clinical trials as therapeutic options...
May 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29721912/a-middle-eastern-founder-mutation-expands-the-genotypic-and-phenotypic-spectrum-of-mitochondrial-micu1-deficiency-a-report-of-13-patients
#9
Sara Musa, Wafaa Eyaid, Kimberli Kamer, Rehab Ali, Mariam Al-Mureikhi, Noora Shahbeck, Fatma Al Mesaifri, Nawal Makhseed, Zakkiriah Mohamed, Wafaa Ali AlShehhi, Vamsi K Mootha, Jane Juusola, Tawfeg Ben-Omran
MICU1 encodes a Ca2+ sensing, regulatory subunit of the mitochondrial uniporter, a selective calcium channel within the organelle's inner membrane. Ca2+ entry into mitochondria helps to buffer cytosolic Ca2+ transients and also activates ATP production within the organelle. Mutations in MICU1 have previously been reported in 17 children from nine families with muscle weakness, fatigue, normal lactate, and persistently elevated creatine kinase, as well as variable features that include progressive extrapyramidal signs, learning disabilities, nystagmus, and cataracts...
May 3, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29721854/abscisic-acid-supplementation-rescues-high-fat-diet-induced-alterations-in-hippocampal-inflammation-and-irss-expression
#10
Alberto Ribes-Navarro, Mariam Atef, Sandra Sánchez-Sarasúa, María Teresa Beltrán-Bretones, Francisco Olucha-Bordonau, Ana María Sánchez-Pérez
Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer's disease. Potential mechanisms underlying insulin resistance include serine phosphorylation of the insulin receptor substrate (IRS) or insulin receptor (IR) misallocation. However, only a few studies have focused on IRS expression in the brain and its modulation in neuroinflammatory processes. This study used the high-fat diet (HFD) model of neuroinflammation to study the alterations of IR, an insulin-like growth factor receptor (IGF1R) and IRS expressions in the hippocampus...
May 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29720892/more-on-the-holographic-ricci-dark-energy-model-smoothing-rips-through-interaction-effects
#11
Mariam Bouhmadi-López, Ahmed Errahmani, Taoufik Ouali, Yaser Tavakoli
The background cosmological dynamics of the late Universe is analysed on the framework of a dark energy model described by an holographic Ricci dark energy component. Several kind of interactions between the dark energy and the dark matter components are considered herein. We solve the background cosmological dynamics for the different choices of interactions with the aim to analyse not only the current evolution of the universe but also its asymptotic behaviour and, in particular, possible future singularities removal...
2018: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/29717429/effect-of-compost-tea-containing-phosphogypsum-on-potato-plant-growth-and-protection-against-fusarium-solani-infection
#12
Mariem Samet, Mariam Charfeddine, Lotfi Kamoun, Oumèma Nouri-Ellouze, Radhia Gargouri-Bouzid
Three composts made of industrial wastes were prepared by mixing olive oil mill waste water (OMW), olive pomace, coffee grounds, and phosphogypsum (0, 10, and 30%). Potato plants (Solanum tuberosum) cultivated in a greenhouse were used to screen compost tea suppressive ability. All compost tea treatments inhibited Fusarium solani growth and improved plant growth and response to F. solani infection. The antagonistic effects of the different treatments were associated with a marked increase of the antioxidant enzymes and PR (pathogenesis related) protein expression and a decrease of disease severity...
May 2, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29716794/proliferative-glomerulonephritis-with-monoclonal-immunoglobulin-g-deposits-is-associated-with-high-rate-of-early-recurrence-in-the-allograft
#13
Samar M Said, Fernando G Cosio, Anthony M Valeri, Nelson Leung, Sanjeev Sethi, Hassan Salameh, Lynn D Cornell, Mary E Fidler, Mariam P Alexander, Fernando C Fervenza, Maria Eleni Drosou, Da Zhang, Vivette D D'Agati, Samih H Nasr
The characteristics of allograft proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (PGNMID) are not well defined. To better characterize this disease we retrospectively identified 26 patients with allograft PGNMID, including 16 followed with early protocol biopsies. PGNMID was found to be a recurrent disease in most (89%) patients. A diagnostic biopsy was done for proteinuria and/or increased creatinine in most patients. Median time from transplant to diagnostic biopsy was 5.5 months, with detection within three to four months post-transplant in 86% of patients...
April 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29713389/establishing-post-mortem-criteria-for-the-metabolic-syndrome-an-autopsy-based-cross-sectional-study
#14
Martin Roest Christensen, Anne Bugge, Mariam Elmegaard Malik, Jørgen Lange Thomsen, Niels Lynnerup, Jørgen Rungby, Jytte Banner
Background: Individuals who suffer from mental illness are more prone to obesity and related co-morbidities, including the metabolic syndrome. Autopsies provide an outstanding platform for the macroscopic, microscopic and molecular-biological investigation of diseases. Autopsy-based findings may assist in the investigation of the metabolic syndrome. To utilise the vast information that an autopsy encompasses to elucidate the pathophysiology behind the syndrome further, we aimed to both develop and evaluate a method for the post mortem definition of the metabolic syndrome...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29713054/structures-of-angptl3-and-angptl4-modulators-of-triglyceride-levels-and-coronary-artery-disease
#15
Ekaterina Biterova, Mariam Esmaeeli, Heli I Alanen, Mirva Saaranen, Lloyd W Ruddock
Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29709582/differential-effects-of-sustained-and-transient-effort-triggered-by-reward-a-combined-eeg-and-pupillometry-study
#16
Mariam Kostandyan, Klaas Bombeke, Thomas Carsten, Ruth M Krebs, Wim Notebaert, C Nico Boehler
In instrumental task contexts, incentive manipulations such as posting reward on successful performance usually trigger increased effort, which is signified by effort markers like increased pupil size. Yet, it is not fully clear under which circumstances incentives really promote performance, and which role effort plays therein. In the present study, we compared two schemes of associating reward with a Flanker task, while simultaneously acquiring electroencephalography (EEG) and pupillometry data in order to explore the contribution of effort-related processes...
April 27, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29706594/patients-perspectives-on-how-to-decrease-the-burden-of-treatment-a-qualitative-study-of-hiv-care-in-sub-saharan-africa
#17
Viet-Thi Tran, Eugene Messou, Mariam Mama Djima, Philippe Ravaud, Didier K Ekouevi
OBJECTIVE: Patients living with HIV infection (PLWH) in sub-Saharan Africa face an important burden of treatment related to everything they do to take care of their health: doctor visits, tests, regular refills, travels, and so on. In this study, we involved PLWH in proposing ideas on how to decrease their burden of treatment and assessed to what extent these propositions could be implemented in care. METHODS: Adult PLWH recruited in three HIV care centres in Côte d'Ivoire participated in qualitative interviews starting with ' What do you believe are the most important things to change in your care to improve your burden of treatment? ' Two independent investigators conducted a thematic analysis to identify and classify patients' propositions to decrease their burden of treatment...
April 29, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29703229/impact-of-an-integrated-control-campaign-on-tsetse-populations-in-burkina-faso
#18
Lassané Percoma, Adama Sow, Soumaïla Pagabeleguem, Ahmadou H Dicko, Oumarou Serdebéogo, Mariam Ouédraogo, Jean-Baptiste Rayaissé, Jérémy Bouyer, Adrien M G Belem, Issa Sidibé
BACKGROUND: Tsetse flies are the sole vectors of human and animal trypanosomosis. In Burkina Faso, a project aiming to create zones free of tsetse flies and trypanosomosis was executed from June 2006 to December 2013. After the determination of tsetse distribution in the intervention area from December 2007 to November 2008, the control campaign was launched in November 2009 and ended in December 2013. The goal was to eliminate tsetse flies from 40,000 km2 of area, through an integrated control campaign including insecticide targets, traps and cattle, sequential aerial treatment (SAT) and the mass treatment of livestock using trypanocides...
April 27, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29702563/hepatitis-c-in-pregnancy
#19
Pratima Dibba, Rosann Cholankeril, Andrew A Li, Meera Patel, Mariam Fayek, Christy Dibble, Nnenna Okpara, Autumn Hines, Aijaz Ahmed
The prevalence of hepatitis C in pregnancy is as high as 3.6% in large cohorts. The prevalence of hepatitis C acquired by vertical transmission is 0.2% to 0.4% in the United States and Europe. Although screening is not recommended in the absence of certain risk factors, the importance of understanding hepatitis C in pregnancy lies in its association with adverse maternal and neonatal outcomes. There is potential for those infants infected by vertical transmission to develop chronic hepatitis C, cirrhosis or hepatocellular carcinoma...
April 27, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29697190/treatment-of-retinoblastoma-in-sub-saharan-africa-experience-of-the-paediatric-oncology-unit-at-gabriel-toure-teaching-hospital-and-the-institute-of-african-tropical-ophthalmology-bamako-mali
#20
Fousseyni Traoré, Fatou Sylla, Boubacar Togo, Bakarou Kamaté, Konimba Diabaté, Abdoul Aziz Diakité, Hawa Diall, Fatoumata Dicko, Mariam Sylla, Pierre Bey, Laurence Desjardins, Anne Gagnepain-Lacheteau, Carole Coze, Mhamed Harif, François Doz
BACKGROUND: Retinoblastoma (Rb) is the most common intraocular primary malignancy in children. In industrialised countries, the cure rate is about 95%. We present the results of a prospective study on the management of Rb in the paediatric oncology unit of Gabriel Touré Teaching Hospital and African Institute of Tropical Ophthalmology, from November 1, 2011 to December 31, 2015. PROCEDURE: The aims of this prospective study were to evaluate the treatment of localised Rb, ocular prosthesis after enucleation, conservative management for bilateral Rb as well as survival rates in all patients...
April 26, 2018: Pediatric Blood & Cancer
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