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https://www.readbyqxmd.com/read/28805277/two-dimensional-physical-gels-can-exist-even-at-zero-surface-pressure-at-the-air-water-interface-rheology-of-self-assembled-domains-of-small-molecules
#1
Mariam Veschgini, Taichi Habe, Salomé Mielke, Shigeto Inoue, Xianhe Liu, Marie Pierre Krafft, Motomu Tanaka
Films of mesoscopic domains self-assembled from fluorocarbon/hydrocarbon diblocks (FnHm) at the air/water interface were found to display highly elastic behavior. We determined the interfacial viscoelasticity of domain-patterned FnHm Langmuir monolayers by applying periodic shear stresses. Remarkably, we found the formation of two-dimensional gels even at zero surface pressure. These monolayers are predominantly elastic, which is unprecedented for surfactants, exhibiting gelation only at high surface pressures...
August 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28800838/noncompliance-with-surgical-antimicrobial-prophylaxis-guidelines-a-jordanian-experience-in-cesarean-deliveries
#2
Mariam Hantash Abdel Jalil, Khawla Abu Hammour, Mervat Alsous, Rand Hadadden, Wedad Awad, Faris Bakri, Kamil Fram
BACKGROUND: Surgical site infections are common, especially in developing countries. Nevertheless, up to 60% of surgical site infections can be prevented with appropriate perioperative care, which includes among other measures using suitable surgical antimicrobial prophylaxis (SAP). METHODS: After a short interview with patients and retrospective review of medical charts, compliance with 6 SAP parameters was assessed for appropriateness; those parameters are indication, choice, dose, time of administration, intraoperative redosing interval, and duration of prophylaxis in 1,173 operations...
August 8, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28797518/telemedicine-in-the-treatment-of-patients-with-inflammatory-bowel-disease
#3
Mariam Aguas, Javier Del Hoyo, Raquel Faubel, Bernardo Valdivieso, Pilar Nos
Inflammatory bowel disease (IBD) is a chronic and relapsing disorder with significant medical, social and financial impacts. IBD patients require continuous follow-up, and healthcare resource use in this context increases over time. In the last decade, telemedicine has influenced the treatment of chronic diseases like IBD via the application of information and communication technologies to provide healthcare services remotely. Telemedicine and its various applications (telemanagement, teleconsulting and tele-education) enable closer follow-up and provide education resources that promote patient empowerment, encouraging treatment optimisation over the entire course of the disease...
August 7, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28794475/dynamic-mechano-regulation-of-myoblast-cells-on-supramolecular-hydrogels-cross-linked-by-reversible-host-guest-interactions
#4
Marcel Hörning, Masaki Nakahata, Philip Linke, Akihisa Yamamoto, Mariam Veschgini, Stefan Kaufmann, Yoshinori Takashima, Akira Harada, Motomu Tanaka
A new class of supramolecular hydrogels, cross-linked by host-guest interactions between β-cyclodextrin (βCD) and adamantane, were designed for the dynamic regulation of cell-substrate interactions. The initial substrate elasticity can be optimized by selecting the molar fraction of host- and guest monomers for the target cells. Moreover, owing to the reversible nature of host-guest interactions, the magnitude of softening and stiffening of the substrate can be modulated by varying the concentrations of free, competing host molecules (βCD) in solutions...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28791310/prevalence-of-diabetic-foot-ulcer-and-associated-factors-among-adult-diabetic-patients-who-attend-the-diabetic-follow-up-clinic-at-the-university-of-gondar-referral-hospital-north-west-ethiopia-2016-institutional-based-cross-sectional-study
#5
Tesfamichael G Mariam, Abebaw Alemayehu, Eleni Tesfaye, Worku Mequannt, Kiber Temesgen, Fisseha Yetwale, Miteku Andualem Limenih
Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. An institutional-based cross-sectional study was conducted in Gondar University Hospital, Ethiopia, to investigate foot ulcer occurrence in diabetic patients. Systematic random sampling was used to select 279 study participants...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28783537/investigation-of-the-hd-semg-probability-density-function-shapes-with-varying-muscle-force-using-data-fusion-and-shape-descriptors
#6
Mariam Al Harrach, Sofiane Boudaoud, Vincent Carriou, Jeremy Laforet, Adrien J Letocart, Jean-François Grosset, Frédéric Marin
This work presents an evaluation of the High Density surface Electromyogram (HD-sEMG) Probability Density Function (PDF) shape variation according to contraction level. On that account, using PDF shape descriptors: High Order Statistics (HOS) and Shape Distances (SD), we try to address the absence of a consensus for the sEMG non-Gaussianity evolution with force variation. This is motivated by the fact that PDF shape information are relevant in physiological assessment of the muscle architecture and function, such as contraction level classification, in complement to classical amplitude parameters...
August 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28782512/quantitative-expression-and-localization-of-gabab-receptor-protein-subunits-in-hippocampi-from-patients-with-refractory-temporal-lobe-epilepsy
#7
REVIEW
Mariam A Sheilabi, Dev Battacharyya, Laura Caetano, Maria Thom, Markus Reuber, John S Duncan, Alessandra P Princivalle
This study investigates GABAB protein expression and mRNA levels in three types of specimens. Two types of specimens from patients with temporal lobe epilepsy (TLE), secondary to hippocampal sclerosis, sclerotic hippocampal samples (TLE-HS), and tissue from the structurally preserved non-spiking ipsilateral superior temporal gyrus (TLE-STG) removed from the same patient during epilepsy surgery; and third specimen is hippocampal tissue from individuals with no history of epilepsy (post-mortem controls, PMC)...
August 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28776099/impact-of-dust-exposure-on-mixed-bacterial-cultures-and-during-eukaryotic-cell-co-culture-infections
#8
Mariam Bado, Syntia Kwende, Shishir Shishodia, Jason A Rosenzweig
On a daily basis, humans, and their colonizing microbiome, are exposed to both indoor and outdoor dust, containing both deleterious organic and inorganic contaminants, through dermal contact, inhalation, and ingestion. Recent studies evaluating the dust exposure responses of opportunistic pathogens, such as Escherichia coli and Pseudomonas aeruginosa, revealed significant increases in biofilm formation following dust exposure. In this study, the effects of dust exposure on mixed bacterial cultures as well as HT-29 co-cultures were evaluated...
August 3, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28771084/mechanisms-of-action-of-uncaria-rhynchophylla-ethanolic-extract-for-its-vasodilatory-effects
#9
Yean Chun Loh, Yung Sing Ch'ng, Chu Shan Tan, Mariam Ahmad, Mohd Zaini Asmawi, Mun Fei Yam
Uncaria rhynchophylla is one of the major components included in Traditional Chinese Medicine prescriptions for hypertensive treatment. Previous studies have suggested that U. rhynchophylla might contain vasodilation-mediating active compounds, especially indole alkaloids. Hence, this study was carried out to determine the vasodilatory effects of U. rhynchophylla, which was extracted by different solvents. The most effective extract was then further studied for its signaling mechanism pathways. The authenticity of U...
August 3, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28770904/traumatic-dislocation-of-phakic-anterior-chamber-iris-claw-intraocular-lens-a-case-report
#10
Nauman Hashmani, Mariam Saleem, Hina Rajani, Sharif Hashmani
We are presenting a traumatic dislocation of a Phakic intraocular lens (PIOL) secondary to a blunt trauma to the right eye. The patient presented with a sudden blurring of vision with no other associated injury. His slit lamp examination showed disenclavation of the temporal clip and pre-operatively his best spectacle-corrected visual acuity (BSCVA) was 6/36. The patient was brought to the operating room where his lens was repositioned and re-enclaved. He had a complete restoration of vision with a BSCVA of 6/9 and an endothelial cell count of 2786/mm2...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28769880/human-gut-microbiota-toward-an-ecology-of-disease
#11
REVIEW
Susannah Selber-Hnatiw, Belise Rukundo, Masoumeh Ahmadi, Hayfa Akoubi, Hend Al-Bizri, Adelekan F Aliu, Tanyi U Ambeaghen, Lilit Avetisyan, Irmak Bahar, Alexandra Baird, Fatema Begum, Hélène Ben Soussan, Virginie Blondeau-Éthier, Roxane Bordaries, Helene Bramwell, Alicia Briggs, Richard Bui, Matthew Carnevale, Marisa Chancharoen, Talia Chevassus, Jin H Choi, Karyne Coulombe, Florence Couvrette, Samantha D'Abreau, Meghan Davies, Marie-Pier Desbiens, Tamara Di Maulo, Sean-Anthony Di Paolo, Sabrina Do Ponte, Priscyla Dos Santos Ribeiro, Laure-Anne Dubuc-Kanary, Paola K Duncan, Frédérique Dupuis, Sara El-Nounou, Christina N Eyangos, Natasha K Ferguson, Nancy R Flores-Chinchilla, Tanya Fotakis, Mariam Gado Oumarou H D, Metodi Georgiev, Seyedehnazanin Ghiassy, Natalija Glibetic, Julien Grégoire Bouchard, Tazkia Hassan, Iman Huseen, Marlon-Francis Ibuna Quilatan, Tania Iozzo, Safina Islam, Dilan B Jaunky, Aniththa Jeyasegaram, Marc-André Johnston, Matthew R Kahler, Kiranpreet Kaler, Cedric Kamani, Hessam Karimian Rad, Elisavet Konidis, Filip Konieczny, Sandra Kurianowicz, Philippe Lamothe, Karina Legros, Sebastien Leroux, Jun Li, Monica E Lozano Rodriguez, Sean Luponio-Yoffe, Yara Maalouf, Jessica Mantha, Melissa McCormick, Pamela Mondragon, Thivaedee Narayana, Elizaveta Neretin, Thi T T Nguyen, Ian Niu, Romeo B Nkemazem, Martin O'Donovan, Matthew Oueis, Stevens Paquette, Nehal Patel, Emily Pecsi, Jackie Peters, Annie Pettorelli, Cassandra Poirier, Victoria R Pompa, Harshvardhan Rajen, Reginald-Olivier Ralph, Josué Rosales-Vasquez, Daria Rubinshtein, Surya Sakr, Mohammad S Sebai, Lisa Serravalle, Fily Sidibe, Ahnjana Sinnathurai, Dominique Soho, Adithi Sundarakrishnan, Veronika Svistkova, Tsolaye E Ugbeye, Megan S Vasconcelos, Michael Vincelli, Olga Voitovich, Pamela Vrabel, Lu Wang, Maryse Wasfi, Cong Y Zha, Chiara Gamberi
Composed of trillions of individual microbes, the human gut microbiota has adapted to the uniquely diverse environments found in the human intestine. Quickly responding to the variances in the ingested food, the microbiota interacts with the host via reciprocal biochemical signaling to coordinate the exchange of nutrients and proper immune function. Host and microbiota function as a unit which guards its balance against invasion by potential pathogens and which undergoes natural selection. Disturbance of the microbiota composition, or dysbiosis, is often associated with human disease, indicating that, while there seems to be no unique optimal composition of the gut microbiota, a balanced community is crucial for human health...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28765202/case-3-painless-vision-loss-in-an-adolescent
#12
Mariam Gabrial, Shamim Islam, Jamie Schaefer, Matthew Pihlblad
No abstract text is available yet for this article.
August 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/28762556/nadph-oxidase-5-nox5-induced-reactive-oxygen-signaling-modulates-normoxic-hif-1%C3%AE-and-p27-kip1-expression-in-malignant-melanoma-and-other-human-tumors
#13
Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow
NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. To evaluate and validate NOX5 expression in human tumors, we screened a broad range of tissue microarrays (TMAs), and report substantial overexpression of NOX5 in malignant melanoma and cancers of the prostate, breast, and ovary. In human UACC-257 melanoma cells that possesses high levels of functional endogenous NOX5, overexpression of NOX5 resulted in enhanced cell growth, increased numbers of BrdU positive cells, and increased γ-H2AX levels...
August 1, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28762467/sulfasalazine-induced-agranulocytosis-is-associated-with-the-human-leukocyte-antigen-locus
#14
Mia Wadelius, Niclas Eriksson, Reinhold Kreutz, Emmanuelle Bondon-Guitton, Luisa Ibañez, Alfonso Carvajal, M Isabel Lucena, Esther Sancho Ponce, Mariam Molokhia, Javier Martin, Tomas Axelsson, Hugo Kohnke, Qun-Ying Yue, Patrik K E Magnusson, Mats Bengtsson, Pär Hallberg
Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease. We performed a genome-wide association study comprising 9,380,034 polymorphisms and 180 HLA alleles in 36 cases of sulfasalazine-induced agranulocytosis and 5,170 population controls. Sulfasalazine-induced agranulocytosis was significantly associated with the HLA region on chromosome 6. The top hit (rs9266634) was located close to HLA-B, odds ratio (OR) 5.36 (95%CI [2...
August 1, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28761763/premature-valvular-heart-disease-in-homozygous-familial-hypercholesterolemia
#15
Akl C Fahed, Kamel Shibbani, Rabih R Andary, Mariam T Arabi, Robert H Habib, Denis D Nguyen, Fady F Haddad, Elie Moubarak, Georges Nemer, Sami T Azar, Fadi F Bitar
Valvular heart disease frequently occurs as a consequence of premature atherosclerosis in individuals with familial hypercholesterolemia (FH). Studies have primarily focused on aortic valve calcification in heterozygous FH, but there is paucity of data on the incidence of valvular disease in homozygous FH. We performed echocardiographic studies in 33 relatively young patients (mean age: 26 years) with homozygous FH (mean LDL of 447 mg/dL, 73% on LDL apheresis) to look for subclinical valvulopathy. Twenty-one patients had evidence of valvulopathy of the aortic or mitral valves, while seven subjects showed notable mitral regurgitation...
2017: Cholesterol
https://www.readbyqxmd.com/read/28759710/functional-integrity-in-children-with-anoxic-brain-injury-from-drowning
#16
Mariam Ishaque, Janessa H Manning, Mary D Woolsey, Crystal G Franklin, Elizabeth W Tullis, Christian F Beckmann, Peter T Fox
Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and chronically. Structural neuroimaging modalities (CT and MRI) have been of limited clinical value. Here, we tested the utility of resting-state functional MRI (rs-fMRI) for assessing brain functional integrity in this population...
July 31, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28759102/a-biaxial-strain-based-expansion-mechanism-for-auxetic-stent-deployment
#17
Faiza Bukhari, Umar Ansari, Murtaza Najabat Ali, Hafsah Akhtar, Sarim Asif, Umer Mohammad, Mariam Mir
BACKGROUND: Auxetics, a special class of materials, tend to expand both in the radial and longitudinal directions when a unidirectional tensile force is applied. Recently, studies have come up with new designs for auxetic vascular and nonvascular stents which are deployed with commercial balloon catheters. There are some inherent limitations associated with a unidirectional application of expansion force in the effective deployment of stents. This work proposed a solution to some of these limitations through the use of a biaxial mode of a predetermined strain-based expansion mechanism...
July 27, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28752452/knockdown-of-z-mutant-alpha-1-antitrypsin-in-vivo-using-modified-dna-antisense-oligonucleotides
#18
Mariam Aghajan, Shuling Guo, Brett P Monia
Alpha-1 antitrypsin (AAT) is a serum protease inhibitor, mainly expressed in and secreted from hepatocytes, important for regulating neutrophil elastase activity among other proteases. Various mutations in AAT cause alpha-1 antitrypsin deficiency (AATD), a rare hereditary disorder that results in liver disease due to accumulation of AAT aggregates and lung disease from excessive neutrophil elastase activity. PiZ transgenic mice contain the human AAT genomic region harboring the most common AATD mutation, the Glu342Lys (Z) point mutation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28751241/flexibility-assessment-of-the-unfused-thoracic-segments-above-the-potential-upper-instrumented-vertebra-using-the-supine-side-bending-radiographs-in-lenke-5-and-6-curves-for-adolescent-idiopathic-scoliosis-patients
#19
Mun Keong Kwan, Chee Kidd Chiu, Teik Seng Chan, Siti Mariam Abd Gani, Tan Shurn Heng, Chris Yin Wei Chan
BACKGROUND CONTEXT: Selection of UIV for Lenke 5 and 6 curves remains debatable, and several authors had described different selection strategies. OBJECTIVE: This study analyzed the flexibility of the unfused thoracic segments above the 'potential upper instrumented vertebrae (UIV)' (T1 to T12) and its compensatory ability in Lenke 5 and 6 curves using supine side bending (SSB) radiographs. STUDY DESIGN: Retrospective study PATIENT SAMPLE: 100 patients OUTCOME MEASURES: The ability of the unfused thoracic segments above the 'potential upper instrumented vertebrae (UIV)' i...
July 24, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28749478/molecular-autopsy-in-maternal-fetal-medicine
#20
Hanan E Shamseldin, Wesam Kurdi, Fatima Almusafri, Maha Alnemer, Alya Alkaff, Zeneb Babay, Amal Alhashem, Maha Tulbah, Nada Alsahan, Rubina Khan, Bahauddin Sallout, Elham Al Mardawi, Mohamed Zain Seidahmed, Niema Meriki, Yasser Alsaber, Alya Qari, Ola Khalifa, Wafaa Eyaid, Zuhair Rahbeeni, Ahmed Kurdi, Mais Hashem, Tarfa Alshidi, Eman Al-Obeid, Firdous Abdulwahab, Niema Ibrahim, Nour Ewida, Karen El-Akouri, Mariam Al Mulla, Tawfeg Ben-Omran, Matthias Pergande, Sebahattin Cirak, Saeed Al Tala, Ranad Shaheen, Eissa Faqeih, Fowzan S Alkuraya
PurposeThe application of genomic sequencing to investigate unexplained death during early human development, a form of lethality likely enriched for severe Mendelian disorders, has been limited.MethodsIn this study, we employed exome sequencing as a molecular autopsy tool in a cohort of 44 families with at least one death or lethal fetal malformation at any stage of in utero development. Where no DNA was available from the fetus, we performed molecular autopsy by proxy, i.e., through parental testing.ResultsPathogenic or likely pathogenic variants were identified in 22 families (50%), and variants of unknown significance were identified in further 15 families (34%)...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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