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Chengquan Ma, Yaguang Zhou, Sufen Zhou, Kun Zhao, Bingxin Lu, Erlin Sun
BACKGROUND AND AIM: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma. METHODS: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012...
October 11, 2016: Oncotarget
Michael Bickell, Jonathan Beilan, Jared Wallen, Lucas Wiegand, Rafael Carrion
This article reviews the most up-to-date surgical treatment options for the reconstructive management of patients with penile, urethral, and scrotal cancer. Each organ system is examined individually. Techniques and discussion for penile cancer reconstruction include Mohs surgery, glans resurfacing, partial and total glansectomy, and phalloplasty. Included in the penile cancer reconstruction section is the use of penile prosthesis in phalloplasty patients after penectomy, tissue engineering in phallic regeneration, and penile transplantation...
November 2016: Urologic Clinics of North America
Juanita Crook
Squamous cell cancer of the penis is a radiocurable malignancy all too often managed solely by partial or total penectomy. Effective management of the primary tumor while preserving penile morphology and function is a priority. External radiotherapy and brachytherapy have a role to play in the definitive management of the primary tumor. Surgical nodal staging remains a cornerstone of management because it is the strongest predictor of survival, and inguinal status determines pelvic management. Postoperative radiotherapy of the regional nodes for high-risk pathology is indicated...
November 2016: Urologic Clinics of North America
Tharani Mahesan, Paul K Hegarty, Nicolas A Watkin
Penile-preserving surgery offers a revolutionary alternative to more traditional radical surgery. It offers better sexual, functional, and psychological results and evidence suggests it achieves this without sacrificing oncological outcomes. We examined the evolving nature of such surgeries, addressing controversies such as safe margins and survival outcomes and discussing more conventional techniques, including laser. At our UK center, we treat a high volume of penile cancer and here, based on such experience, we describe our glans resurfacing, glansectomy, and partial penectomy techniques; their application by disease stage; and the limitations of such surgeries...
November 2016: Urologic Clinics of North America
Roman Sosnowski, Marta Kulpa, Mariola Kosowicz, Jan Karol Wolski, Olga Kuczkiewicz, Katarzyna Moskal, Michał Szymański, Tomasz Kalinowski, Tomasz Demkow
INTRODUCTION: Total amputation, as a treatment for advanced penile cancer, significantly debilitates the patient's quality of life and sexual function. The aim of the study was to assess the quality of life in patients who had undergone total penectomy. MATERIAL AND METHODS: The questionnaires EORTC QLQ C-30, SES, CMNI, and a modified IIEF-15 questionnaire, were sent to 11 patients. RESULTS: A total of 10 patients returned the questionnaires completed...
2016: Central European Journal of Urology
Antonio Jose Reyes, Kanterpersad Ramcharan, Lester Goetz, Samuel Aboh
No abstract text is available yet for this article.
2016: BMJ Case Reports
Matthew Mossanen, Sarah Holt, John L Gore, Daniel W Lin, Jonathan L Wright
BACKGROUND: Penile cancer remains a rare disease in the United States, and its understanding may be limited by the uncommon nature of the malignancy. We sought to describe recent penile cancer treatment patterns using the National Cancer Data Base. METHODS: A retrospective review of data obtained from the National Cancer Data Base from 1998 to 2012 was performed. We obtained demographic information and therapeutic approaches within the following2 clinical scenarios: performance of partial penectomy for early stage disease (clinical Ta-T2) and the use of chemotherapy for metastatic disease...
August 2, 2016: Urologic Oncology
Masato Funazumi, Takeshi Namiki, Yumi Arima, Kohei Kato, Kohei Nojima, Kentaro Tanaka, Keiko Miura, Hiroo Yokozeki
Primary penile melanomas are rare tumors that represent less than 0.1% of all melanomas. We report a case of a 60-year-old Japanese male with a mucosal penile melanoma and describe an increased CD8(+) T cell infiltration in brain after dacarbazine (DTIC) administration. After partial penectomy and left inguinal lymphadenectomy, he developed multiple lung, bone, spleen, brain and skin metastases. He was treated with interferon-β, DTIC and nivolumab. However, the metastases were not reduced in size. Immunohistochemistry showed an increase of CD8(+) T cell infiltration and programmed death-ligand 1 (PD-L1) expression after the administration of DTIC, but the expression of programmed cell death protein 1 (PD-1) was negative...
August 2016: Annals of Dermatology
Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun-Ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi, Masahiro Yao, Yasushi Yumura, Hiroshi Miyamoto, Hiroji Uemura
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. METHODS: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed...
2016: BMC Cancer
Punit Sharma
Penile cancer is rare cancer. While inguinal and pelvic nodal metastasis is common, distant metastasis is rare. We here present the interesting case of a 59-year-old male patient with penile carcinoma, previously treated with penectomy and inguinal lymphadenectomy 10 years earlier. He presented with bone pains and given history of malignancy he was referred for an (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). PET/CT demonstrated multiple (18)F-FDG avid bone and lung metastases...
July 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Francesco De Luca, Evangelos Zacharakis, Majed Shabbir, Angela Maurizi, Emy Manzi, Antonio Zanghì, Carlo De Dominicis, David Ralph
Malignant priapism secondary to penile metastases is a rare condition. This term was originally used by Peacock in 1938 to describe a condition of painful induration and erection of the penis due to metastatic infiltration by a neoplasm. In the current literature there are 512 case reports. The primary tumor sites are bladder, prostate and rectum. The treatment has only palliative intent and consists of local tumor excision, penectomy, radiotherapy and chemotherapy. We present one case of malignant priapism originated from prostate cancer, and two from urothelial carcinoma of the bladder...
2016: Archivio Italiano di Urologia, Andrologia
Eric L Maranda, Austin H Nguyen, Victoria M Lim, Vidhi V Shah, Joaquin J Jimenez
Erythroplasia of Queyrat (EOQ) is a squamous cell carcinoma in situ most commonly located on the glans penis or prepuce. EOQ accounts for roughly 10 % of all penile malignancies and may lead to invasive squamous cell carcinoma. Standard therapy includes local excision, partial or total penectomy, cryotherapy, and topical cytotoxic agents. Treatment of EOQ has proven to be challenging due to low response rates and recurrence. In addition, radical procedures can significantly affect sexual function and quality of life...
June 21, 2016: Lasers in Medical Science
Mohabe A Vinson, Onyinyechukwu Okorji, Raul Gagucas
Carcinoma cuniculatum is an uncommon variation of squamous cell carcinoma (SCC) has been documented in a few cases at various locations of the body such as penis, foot, jaw, oropharynx and esophagus. In this case, a 79-year-old male presents with a penile mass, which he underwent a total penectomy. Histology of the mass was defined as carcinoma cuniculatum with negative margins and no lymphovascular invasion. This variant of SCC rarely metastasizes. A joint decision was made to observe lymph nodes. It is important to differentiate the different SCC because patient care can be guided based on the pathology...
September 2016: Urology Case Reports
Toshihiko Hoashi, Kanako Kikuchi, Shinichi Sato, Hidehisa Saeki
Basal cell carcinoma is the most common cutaneous malignant tumor and usually arises from the facial skin and is diagnosed as the solid tumor. However, rarely it arises from genital skin and/or proceeds with ulcerative manner. We report a case of male basal cell carcinoma arising from penile base, which showed urinary disturbance. Tumor resection including total penectomy and skin resection was performed then scrotal myofasciocutaneous flap was used to cover the defect. Scrotal myofasciocutaneous flap was useful for covering the defect in the genital lesion...
June 6, 2016: Dermatologic Therapy
Giuseppe Lucarelli, Marco Spilotros, Antonio Vavallo, Silvano Palazzo, Carlos Miacola, Saverio Forte, Matteo Matera, Marcello Campagna, Ottavio Colamonico, Francesco Schiralli, Francesco Sebastiani, Federica Di Cosmo, Carlo Bettocchi, Giuseppe Di Lorenzo, Carlo Buonerba, Leonardo Vincenti, Giuseppe Ludovico, Pasquale Ditonno, Michele Battaglia
Primary urethral carcinoma (PUC) is a rare and aggressive cancer, often underdetected and consequently unsatisfactorily treated. We report a case of advanced PUC, surgically treated with combined approaches.A 47-year-old man underwent transurethral resection of a urethral lesion with histological evidence of a poorly differentiated squamous cancer of the bulbomembranous urethra. Computed tomography (CT) and bone scans excluded metastatic spread of the disease but showed involvement of both corpora cavernosa (cT3N0M0)...
May 2016: Medicine (Baltimore)
Fernando N Facio, Luis C Spessoto, Germano J Ferraz de Arruda, Jeronimo F Arruda, Jose G Ferraz de Arruda, Maria Fernanda W Facio
Primary urethral carcinoma is much more common in women than in men due to its association with urethritis. A 65-year-old man presented with a 10-month history of penile induration, obstructive voiding symptoms and hematuria. Urethrocystoscopy showed a solitary mass in the proximal urethra and no bladder involvement. It was performed penectomy without bladder neck excision and regional staging lymphadenectomy of the obturator lymph nodes. Pathological diagnosis revealed adenosquamous cell carcinoma with squamous and glandular components...
May 2016: Urology Case Reports
Khanh N Pham, Mitchell H Sokoloff, Charles A Steiger
We report an interesting case of Buerger's disease that manifested at the glans penis in a 56 year-old former smoker. Penile involvement in Buerger's disease is rare. Our patient had no prior extremity or digit amputations in his 4-year history of Buerger's disease. However, our patient did suffer from recurrent penile ulcers over an 8-week timeframe that ultimately progressed to a gangrenous, unsalvageable glans penis. He underwent a partial penectomy and urethral reconstruction with excellent post-operative results...
2016: American Journal of Clinical and Experimental Urology
Gianluca Franceschini, Alejandro Martin Sanchez, Alba Di Leone, Assunta Scaldaferri, Massimo Ferrucci, Antonio Mulè, Melania Costantini, Riccardo Masetti
BACKGROUND: Penile cancer is a relatively uncommon cancer in developed nations. Metastatic disease is rare, but lymphatic or vascular spreading has been previously reported to the liver, lungs, bones, brain, heart and skin. CASE PRESENTATION: We report a case of a 49-year-old white man with a penile squamous cell carcinoma previously treated with partial penectomy and bilateral inguinal lymph node dissection, followed by adjuvant therapy. Three years after treatment, the primitive neoplasm metastasized to the breast, presenting as a painful lump...
2016: Journal of Medical Case Reports
Shuangping Guo, Chaoliang Fan, Joseph Rohr, Linni Fan, Yingmei Wang, Mingyang Li, Xia Li, Ying Guo, Qingguo Yan, Lu Wang, Zhe Wang
Lymphovascular invasion (LVI) is an independent predictor of metastatic lymph node disease in penile carcinoma and is one factor used to guide clinical management. The presence of LVI with and without the use of the endothelial immunohistochemical (IHC) markers, ERG and CD31, was retrospectively assessed in 46 penectomy cases containing invasive penile carcinoma (43 squamous cell carcinoma and 3 non-squamous cell carcinoma). Concordance for the detection of LVI between the original report, upon pathology review, and with the use of IHC was determined and histologic pitfalls were identified...
July 2016: Histology and Histopathology
Yauhen Tarbunou, Cindy L Davis, Joseph Costa, Christopher Williams
Warty carcinoma of the penis is an unusual neoplasm and a variant of penile squamous cell carcinoma. As with other types of penile cancer, risk factors include human papillomavirus infection, poor personal hygiene, and being uncircumcised. The typical case is an exophytic mass arising from the glans penis, frequently large (4-5 cm), and with invasion into corpus spongiosum. The diagnosis is typically made by tumor biopsy. Treatment depends on the stage of disease and includes partial vs total penectomy, with or without prophylactic or therapeutic bilateral lymphadenectomy...
May 2014: Urology Case Reports
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