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https://www.readbyqxmd.com/read/27919132/-a-case-of-penile-squamous-cell-carcinoma-sarcomatoid-subtype
#1
Tomoki Yamamoto, Takuya Owari, Yuta Toyoshima, Tomonori Nakahama, Satoshi Takada, Yoshihiro Matsumoto, Ikuko Torii, Hitoshi Momose
A 70-year-old man was referred to our department for further examination and treatment of a painless penile mass of about 2cm. The patient first noticed the mass onlya few weeks before presentation. Diagnostic biopsy was interpreted as leiomyosarcoma. Through systemic examinations the clinical stage of his disease was diagnosed as cT2N0M0 and we performed total penectomy. Histopathological examination for the totallyresected tissue disclosed the concomitant presence of regions compatible to squamous cell carcinoma and the results of immunohistochemistrywere compatible with the diagnosis of squamous cell carcinoma, sarcomatoid subtype of the penis...
October 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27905695/erythroplasia-of-queyrat-treated-with-methyl-aminolevulinate-photodynamic-therapy-mal-pdt-case-report-and-review-of-the-literature
#2
Nevena Skroza, Giorgio LA Viola, Riccardo Pampena, Ilaria Proietti, Nicoletta Bernardini, Ersilia Tolino, Alessandro Annetta, Sara Zuber, Veronica Balduzzi, Concetta Potenza
Erythroplasia of Queyrat (EQ) is a rare disease involving the mucosal and transitional surfaces of the penis. Effective treatment is necessary to minimize progression to squamous cell carcinoma. The standard therapy for EQ, partial or radical penectomy, is invasive; photodynamic therapy (PDT) may be an effective, non-surgical tissue-sparing option. We report the case of a 67-year-old patient with long-standing EQ who was successfully treated with methyl aminolevulinate-PDT (MAL-PDT). A complete clinical response, confirmed by incisional biopsy, was achieved after five sessions of every-other-week treatment...
December 1, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27904649/fasciocutaneous-flap-reinforcement-of-ventral-onlay-buccal-mucosa-grafts-enables-neophallus-revision-urethroplasty
#3
Stelios C Wilson, John T Stranix, Kiranpreet Khurana, Shane D Morrison, Jamie P Levine, Lee C Zhao
BACKGROUND: Urethral strictures or fistulas are common complications after phalloplasty. Neourethral defects pose a difficult reconstructive challenge using standard techniques as there is generally insufficient ventral tissue to support a graft urethroplasty. We report our experience with local fasciocutaneous flaps for support of ventrally-placed buccal mucosal grafts (BMGs) in phalloplasty. METHODS: A retrospective review of patients who underwent phalloplasty and subsequently required revision urethroplasty using BMGs between 2011 and 2015 was completed...
December 2016: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/27887019/first-case-of-penile-metastasis-following-abdominoperineal-resection-with-vram-flap-reconstruction
#4
Andrei A Kozan, Adrian M Smith, David W Ilsley, Nicholas Rhodes
Penile metastases are rare in colorectal cancer. We report the first case of such a recurrence in a patient who had undergone an extralevator abdominoperineal resection with vertical rectus abdominis myocutaneous flap perineal reconstruction. The patient was treated with curative intent by total penectomy.
November 24, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27792850/volume-outcome-relationship-in-penile-cancer-treatment-a-population-based-patterns-of-care-and-outcomes-study-from-australia
#5
Manish I Patel, Yuigi Yuminaga, Albert Bang, Nathan Lawrentschuk, Timothy Skyring, David P Smith
OBJECTIVES: To study the patterns of care of penile cancer diagnosed in the state of New South Wales (NSW) over a 10 year period and determine factors that are associated with differences in survival. PATIENTS AND METHODS: All invasive penile cancer diagnosed between 2001 and 2009 in NSW, Australia, were identified from the Central Cancer Registry. Records of treatment from the Admitted Patient Data Collection and deaths from the Registry of Births Deaths and Marriages were electronically linked...
October 2016: BJU International
https://www.readbyqxmd.com/read/27738342/preoperative-peripheral-plasma-fibrinogen-level-is-an-independent-prognostic-marker-in-penile-cancer
#6
Chengquan Ma, Yaguang Zhou, Sufen Zhou, Kun Zhao, Bingxin Lu, Erlin Sun
BACKGROUND AND AIM: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma. METHODS: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27717440/advances-in-surgical-reconstructive-techniques-in-the-management-of-penile-urethral-and-scrotal-cancer
#7
Michael Bickell, Jonathan Beilan, Jared Wallen, Lucas Wiegand, Rafael Carrion
This article reviews the most up-to-date surgical treatment options for the reconstructive management of patients with penile, urethral, and scrotal cancer. Each organ system is examined individually. Techniques and discussion for penile cancer reconstruction include Mohs surgery, glans resurfacing, partial and total glansectomy, and phalloplasty. Included in the penile cancer reconstruction section is the use of penile prosthesis in phalloplasty patients after penectomy, tissue engineering in phallic regeneration, and penile transplantation...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27717430/contemporary-role-of-radiotherapy-in-the-management-of-primary-penile-tumors-and-metastatic-disease
#8
Juanita Crook
Squamous cell cancer of the penis is a radiocurable malignancy all too often managed solely by partial or total penectomy. Effective management of the primary tumor while preserving penile morphology and function is a priority. External radiotherapy and brachytherapy have a role to play in the definitive management of the primary tumor. Surgical nodal staging remains a cornerstone of management because it is the strongest predictor of survival, and inguinal status determines pelvic management. Postoperative radiotherapy of the regional nodes for high-risk pathology is indicated...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27717429/advances-in-penile-preserving-surgical-approaches-in-the-management-of-penile-tumors
#9
Tharani Mahesan, Paul K Hegarty, Nicolas A Watkin
Penile-preserving surgery offers a revolutionary alternative to more traditional radical surgery. It offers better sexual, functional, and psychological results and evidence suggests it achieves this without sacrificing oncological outcomes. We examined the evolving nature of such surgeries, addressing controversies such as safe margins and survival outcomes and discussing more conventional techniques, including laser. At our UK center, we treat a high volume of penile cancer and here, based on such experience, we describe our glans resurfacing, glansectomy, and partial penectomy techniques; their application by disease stage; and the limitations of such surgeries...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27551559/quality-of-life-in-penile-carcinoma-patients-post-total-penectomy
#10
Roman Sosnowski, Marta Kulpa, Mariola Kosowicz, Jan Karol Wolski, Olga Kuczkiewicz, Katarzyna Moskal, Michał Szymański, Tomasz Kalinowski, Tomasz Demkow
INTRODUCTION: Total amputation, as a treatment for advanced penile cancer, significantly debilitates the patient's quality of life and sexual function. The aim of the study was to assess the quality of life in patients who had undergone total penectomy. MATERIAL AND METHODS: The questionnaires EORTC QLQ C-30, SES, CMNI, and a modified IIEF-15 questionnaire, were sent to 11 patients. RESULTS: A total of 10 patients returned the questionnaires completed...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27530883/penectomy-for-self-neglected-opportunistic-carcinoma-a-large-primary-urogenital-squamous-cell-carcinoma-as-initial-manifestation-of-hiv-aids
#11
Antonio Jose Reyes, Kanterpersad Ramcharan, Lester Goetz, Samuel Aboh
No abstract text is available yet for this article.
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27495001/15-years-of-penile-cancer-management-in-the-united-states-an-analysis-of-the-use-of-partial-penectomy-for-localized-disease-and-chemotherapy-in-the-metastatic-setting
#12
Matthew Mossanen, Sarah Holt, John L Gore, Daniel W Lin, Jonathan L Wright
BACKGROUND: Penile cancer remains a rare disease in the United States, and its understanding may be limited by the uncommon nature of the malignancy. We sought to describe recent penile cancer treatment patterns using the National Cancer Data Base. METHODS: A retrospective review of data obtained from the National Cancer Data Base from 1998 to 2012 was performed. We obtained demographic information and therapeutic approaches within the following2 clinical scenarios: performance of partial penectomy for early stage disease (clinical Ta-T2) and the use of chemotherapy for metastatic disease...
December 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27489432/increased-infiltration-of-cd8-t-cells-by-dacarbazine-in-a-patient-with-mucosal-penile-melanoma-refractory-to-nivolumab
#13
Masato Funazumi, Takeshi Namiki, Yumi Arima, Kohei Kato, Kohei Nojima, Kentaro Tanaka, Keiko Miura, Hiroo Yokozeki
Primary penile melanomas are rare tumors that represent less than 0.1% of all melanomas. We report a case of a 60-year-old Japanese male with a mucosal penile melanoma and describe an increased CD8(+) T cell infiltration in brain after dacarbazine (DTIC) administration. After partial penectomy and left inguinal lymphadenectomy, he developed multiple lung, bone, spleen, brain and skin metastases. He was treated with interferon-β, DTIC and nivolumab. However, the metastases were not reduced in size. Immunohistochemistry showed an increase of CD8(+) T cell infiltration and programmed death-ligand 1 (PD-L1) expression after the administration of DTIC, but the expression of programmed cell death protein 1 (PD-1) was negative...
August 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27386948/increased-neutrophil-to-lymphocyte-ratio-is-associated-with-disease-specific-mortality-in-patients-with-penile-cancer
#14
Jun Kasuga, Takashi Kawahara, Daiji Takamoto, Sachi Fukui, Takashi Tokita, Tomoyuki Tadenuma, Masaki Narahara, Syusei Fusayasu, Hideyuki Terao, Koji Izumi, Hiroki Ito, Yusuke Hattori, Jun-Ichi Teranishi, Takeshi Sasaki, Kazuhide Makiyama, Yasuhide Miyoshi, Masahiro Yao, Yasushi Yumura, Hiroshi Miyamoto, Hiroji Uemura
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. METHODS: A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27385892/late-metastatic-recurrence-of-penile-carcinoma-after-10-years-demonstration-with-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#15
Punit Sharma
Penile cancer is rare cancer. While inguinal and pelvic nodal metastasis is common, distant metastasis is rare. We here present the interesting case of a 59-year-old male patient with penile carcinoma, previously treated with penectomy and inguinal lymphadenectomy 10 years earlier. He presented with bone pains and given history of malignancy he was referred for an (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT). PET/CT demonstrated multiple (18)F-FDG avid bone and lung metastases...
July 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27377094/malignant-priapism-due-to-penile-metastases-case-series-and-literature-review
#16
Francesco De Luca, Evangelos Zacharakis, Majed Shabbir, Angela Maurizi, Emy Manzi, Antonio Zanghì, Carlo De Dominicis, David Ralph
Malignant priapism secondary to penile metastases is a rare condition. This term was originally used by Peacock in 1938 to describe a condition of painful induration and erection of the penis due to metastatic infiltration by a neoplasm. In the current literature there are 512 case reports. The primary tumor sites are bladder, prostate and rectum. The treatment has only palliative intent and consists of local tumor excision, penectomy, radiotherapy and chemotherapy. We present one case of malignant priapism originated from prostate cancer, and two from urothelial carcinoma of the bladder...
July 4, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27324019/erythroplasia-of-queyrat-treated-by-laser-and-light-modalities-a-systematic-review
#17
REVIEW
Eric L Maranda, Austin H Nguyen, Victoria M Lim, Vidhi V Shah, Joaquin J Jimenez
Erythroplasia of Queyrat (EOQ) is a squamous cell carcinoma in situ most commonly located on the glans penis or prepuce. EOQ accounts for roughly 10 % of all penile malignancies and may lead to invasive squamous cell carcinoma. Standard therapy includes local excision, partial or total penectomy, cryotherapy, and topical cytotoxic agents. Treatment of EOQ has proven to be challenging due to low response rates and recurrence. In addition, radical procedures can significantly affect sexual function and quality of life...
December 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27313988/extensive-presentation-of-penile-carcinoma-cuniculatum-a-variant-of-squamous-cell-carcinoma-with-low-malignant-potential
#18
Mohabe A Vinson, Onyinyechukwu Okorji, Raul Gagucas
Carcinoma cuniculatum is an uncommon variation of squamous cell carcinoma (SCC) has been documented in a few cases at various locations of the body such as penis, foot, jaw, oropharynx and esophagus. In this case, a 79-year-old male presents with a penile mass, which he underwent a total penectomy. Histology of the mass was defined as carcinoma cuniculatum with negative margins and no lymphovascular invasion. This variant of SCC rarely metastasizes. A joint decision was made to observe lymph nodes. It is important to differentiate the different SCC because patient care can be guided based on the pathology...
September 2016: Urology Case Reports
https://www.readbyqxmd.com/read/27273129/a-case-of-penile-basal-cell-carcinoma-reconstructed-by-scrotal-myofasciocutaneous-flap
#19
Toshihiko Hoashi, Kanako Kikuchi, Shinichi Sato, Hidehisa Saeki
Basal cell carcinoma is the most common cutaneous malignant tumor and usually arises from the facial skin and is diagnosed as the solid tumor. However, rarely it arises from genital skin and/or proceeds with ulcerative manner. We report a case of male basal cell carcinoma arising from penile base, which showed urinary disturbance. Tumor resection including total penectomy and skin resection was performed then scrotal myofasciocutaneous flap was used to cover the defect. Scrotal myofasciocutaneous flap was useful for covering the defect in the genital lesion...
September 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27175683/a-challenging-surgical-approach-to-locally-advanced-primary-urethral-carcinoma-a-case-report-and-literature-review
#20
Giuseppe Lucarelli, Marco Spilotros, Antonio Vavallo, Silvano Palazzo, Carlos Miacola, Saverio Forte, Matteo Matera, Marcello Campagna, Ottavio Colamonico, Francesco Schiralli, Francesco Sebastiani, Federica Di Cosmo, Carlo Bettocchi, Giuseppe Di Lorenzo, Carlo Buonerba, Leonardo Vincenti, Giuseppe Ludovico, Pasquale Ditonno, Michele Battaglia
Primary urethral carcinoma (PUC) is a rare and aggressive cancer, often underdetected and consequently unsatisfactorily treated. We report a case of advanced PUC, surgically treated with combined approaches.A 47-year-old man underwent transurethral resection of a urethral lesion with histological evidence of a poorly differentiated squamous cancer of the bulbomembranous urethra. Computed tomography (CT) and bone scans excluded metastatic spread of the disease but showed involvement of both corpora cavernosa (cT3N0M0)...
May 2016: Medicine (Baltimore)
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