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Penectomy

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https://www.readbyqxmd.com/read/28801692/-urethral-centralization-and-pseudo-glans-formation-after-partial-penectomy
#1
REVIEW
J Kranz, A Parnham, M Albersen, V Sahdev, M Ziada, R Nigam, A Muneer, J Steffens, P Malone
The management of penile cancer has altered dramatically over the last decade. Confidence to excise lesions safely with smaller margins has led to the adoption of penile-preserving techniques and in turn improved the functional and cosmetic results. Patients undergoing partial penectomy (PP) find that the urethral meatus is located in an abnormal ventral position. In addition, there is a high risk of meatal stenosis. We describe our novel technique that allows the urethral meatus to be centralised after PP and creation of a pseudo-glans and wide meatus and therefore maintain the cosmetic appearance of the penis after split thickness skin grafting...
August 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28717280/priapism-with-penile-gangrene-an-unusual-presentation-of-multiple-myeloma
#2
Vikas Kumar Panwar, Ravimohan S Mavuduru, Sudheer Kumar Devana, Kim Vaiphei, Girdhar Singh Bora
Penile gangrene is very rare sequel of ischemic priapism. Previous published reports have shown its occurrence in patients with sickle cell disease, urethral carcinoma, bladder carcinoma, thrombotic thrombocytopenic purpura, idiopathic, traumatic, etc. Ischemic priapism with penile gangrene as an initial presentation of multiple myeloma has not been reported. We present a 44-year-old patient of multiple myeloma presenting with ischemic priapism and penile gangrene requiring partial penectomy.
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28678753/comparison-of-efficacy-between-brachytherapy-and-penectomy-in-patients-with-penile-cancer-a-meta-analysis
#3
Xiheng Hu, Jianghai Huang, Sailan Wen, Jun Fu, Minfeng Chen
We conducted a meta-analysis to compare the efficacy of brachytherapy and penectomy in patients with penile cancer. We searched the published articles in the PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang databases up to March 20, 2017. Twenty-two studies entered the final analyses. We used five-year overall survival rate, five-year local control rate, disease-free progression and lymph node positive rate to assess the efficacy. The meta-analysis found that patients who received penectomy had higher five-year local control rate (85% vs 80%, odds ratio = 0...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28658136/penile-metastases-from-primary-lung-cancer-case-report-and-literature-review
#4
REVIEW
Ling-Chuan Guo, Gang Li, Xi-Ming Wang, Mi Zhang, Jian-An Huang, Yan-Bin Chen
BACKGROUND: Metastasis to the penis from primary lung cancer is quite rare. To improve the understanding, we present a case diagnosed as penile metastasis from primary lung cancer and review the literature. METHODS: One case report and retrospectively analysis penile cancer patient secondary from primary lung cancer. RESULTS: The patient complained of perineal pain and burning on urination for about 2 months. On physical examination, painful nodular masses at the base of left side of the corpora cavernosa were found...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28652123/delay-to-inguinal-lymph-node-dissection-greater-than-3-months-predicts-poorer-recurrence-free-survival-for-penile-cancer-patients
#5
Juan Chipollini, Doninic H Tang, Scott M Gilbert, Michael A Poch, Julio M Pow-Sang, Wade J Sexton, Philippe E Spiess
PURPOSE: It is unknown if concomitant inguinal lymph node dissection (ILND) at time of penectomy improves outcomes for penile cancer patients. We analyzed predictors for regional recurrence as well as recurrence free (RFS) and disease specific (DSS) survival based on time of ILND, and determine an optimal time for performance of ILND. MATERIAL AND METHODS: We reviewed 84 consecutive patients with available nodal pathology. Both RFS and DSS were estimated using the Kaplan-Meier method...
June 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28578871/subclassification-of-pn3-staging-systems-for-penile-cancer-proposal-for-modification-of-the-current-tnm-classification
#6
Zhiyong Li, Shengjie Guo, Zhiming Wu, Hui Han, Zaishang Li, Yanjun Wang, Dong Chen, Jieping Chen, Chuangzhong Deng, Zike Qin, Zhuowei Liu, Yonghong Li, Kai Yao, Fanjian Zhou
OBJECTIVE: To validate the clinical and prognostic significance of our proposed pN3 subclassification in penile cancer. MATERIALS AND METHODS: A retrospective analysis of 509 patients with penile cancer undergoing partial, total penectomy or inguinal lymphadenectomy or pelvic lymphadenectomy at Sun Yat-sen University Cancer Center was reevaluated by pathologists. pN3 stage was subclassified into pN3a (extranodal extension of any inguinal lymph node [LN] metastasis only) and pN3b (pelvic LN metastasis)...
May 31, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28509699/penis-transplantation-first-us-experience
#7
Curtis L Cetrulo, Kai Li, Harry M Salinas, Matthew D Treiser, Ilse Schol, Glen W Barrisford, Francis J McGovern, Adam S Feldman, Michael T Grant, Cigdem Tanrikut, Jeffrey H Lee, Richard J Ehrlichman, Paul W Holzer, Garry M Choy, Raymond W Liu, Zhi Yang Ng, Alexandre G Lellouch, Josef M Kurtz, William G Austen, Jonathan M Winograd, Branko Bojovic, Kyle R Eberlin, Ivy A Rosales, Robert B Colvin, Dicken S C Ko
OBJECTIVE: We describe the first successful penis transplant in the United States in a patient with a history of subtotal penectomy for penile cancer. BACKGROUND: Penis transplantation represents a new paradigm in restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 penis transplants have been performed worldwide. METHODS: After institutional review board approval, extensive medical, surgical, and radiological evaluations of the patient were performed...
May 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28507910/penile-calciphylaxis-the-use-of-radiological-investigations-in-the-management-of-a-rare-and-challenging-condition
#8
Rebecca A Campbell, Laith M Alzweri, Nikolai A Sopko, Katarzyna J Macura, Arthur L Burnett
Penile calciphylaxis is a rare phenomenon of penile necrosis observed in patients with hemodialysis-dependent end-stage renal failure. Multiple treatments have been proposed including conservative management, surgical debridement and penectomy; yet, the prognosis remains extremely poor. Here, we describe a patient with protracted resolution of dry gangrene of the glans, which failed conservative management of wound care and pain management. Radiological studies revealed extensive calcification of abdominal aorta and branching vessels including the penile arteries...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28501419/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-prognostic-factors-and-long-term-analysis-of-outcome
#9
Alexandre Escande, Christine Haie-Meder, Renaud Mazeron, Pierre Maroun, Andrea Cavalcanti, Renaud de Crevoisier, Antoine Schernberg, Fanny Marsolat, Pierre Blanchard, Florent Martinetti, Alberto Bossi, Isabelle Dumas, Eric Deutsch, Cyrus Chargari
PURPOSE: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. METHODS AND MATERIALS: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. RESULTS: With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77...
February 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28459145/clinicopathologic-characteristics-and-treatment-outcomes-of-penile-cancer
#10
Jong Kil Nam, Dong Hoon Lee, Sung Woo Park, Sung Chul Kam, Ki Soo Lee, Tae Hyo Kim, Taek Sang Kim, Cheol Kyu Oh, Hyun Jun Park, Tae Nam Kim
PURPOSE: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival. MATERIALS AND METHODS: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate. RESULTS: Clinicopathologic and outcome information was available for 52 male patients (mean age, 64...
April 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28417078/local-excision-for-the-treatment-of-penile-verrucous-carcinoma
#11
Dong In Jo, Sang Kyu Choi, Soon Heum Kim, Cheol Keun Kim, Hong Chung, Hong Sup Kim
Penile verrucous carcinoma is known for its favorable biologic behavior and lack of metastatic potential. For preservation of function, treatment has been focused on partial penectomy. Despite partial penectomy for preservation of minimal functional and aesthetic aspects, patients have experienced psychosexual problems. A 73-year-old man had a cauliflower-like verrucous carcinoma on the penile glans and coronary sulcus diagnosed by using excisional biopsy. He underwent degloving excision to save the penile shaft and glans penis...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28321087/myelodysplastic-syndrome-diagnosed-on-the-occasion-of-fournier-s-gangrene
#12
Masaaki Adachi, Kimiyoshi Mitsuhashi, Hiroyuki Matsuda, Junko Watanabe, Katsuya Nakanishi
Fournier's gangrene (FG) is a fulminant infective necrotizing fasciitis, which includes the genital, perineal, and perianal regions. A 77-year-old man had previously been diagnosed as having diabetes mellitus (DM) and was treated with pioglitazone (15 mg) and miglitol (150 mg). He developed sudden perineal discomfort, fever with painful penile, and scrotal edema, subsequently leading to urinary retention. According to physical examination and CT scan results for the swollen penis and scrotum, he was diagnosed with FG...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28300890/erythroplasia-of-queyrat-treated-with-topical-5-fluorouracil
#13
João Roberto Antônio, Carlos Roberto Antônio, Lívia Arroyo Trídico, Fernanda Tomé Alves, Ivan Rollemberg
We report a 33-year-old male patient diagnosed with erythroplasia of Queyrat. The patient had an erythematous and eroded lesion affecting more than 50% of the glans associated with bleeding and local pain. Despite previous indication of penectomy, he was successfully treated with topical 5-fluorouracil.
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28286072/organ-sparing-surgery-in-penile-cancer-a-systematic-review
#14
REVIEW
Mohamed H Kamel, Nabil Bissada, Renee Warford, Judy Farias, Rodney Davis
PURPOSE: Although penile cancer represents only 1% of all male cancers, the traditional treatment, total or subtotal penectomy, carries devastating psychological and functional outcomes. Organ sparing surgery is an attractive option if it can provide satisfactory cancer control equivalent to or nearly equivalent to standard techniques. This approach is meeting increasing acceptance. We offer a timely comprehensive review to increase awareness of these procedures and their applicability, to evaluate the techniques objectively and to provide guidance to the practicing urologist...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28212473/-five-year-survival-analysis-in-patients-with-penile-cancer
#15
Álvaro José Montiel-Jarquín, Antonio Jesús Contreras-Díaz, Eduardo Vázquez-Cruz, Marco Antonio Chopin-Gazga, María Socorro Romero-Figueroa, Ivet Etchegaray-Morales, Ivan Alvarado-Ortega
BACKGROUND: Short-term survival of penile cancer is poor. The objective was to describe the 5-years penile cancer survival. METHODS: Retrospective cohort study. We included patients with penile cancer managed surgically from 2010 to 2014. Descriptive statistics were used for socio-demographic variables and the Kaplan-Meier estimator for survival function. RESULTS: We studied 22 patients with a mean age of 64.95 years and a time of evolution of 25 months after the diagnosis...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28209454/treatment-of-carcinoma-in-situ-of-the-glans-penis-with-topical-imiquimod-followed-by-carbon-dioxide-laser-excision
#16
Tullio Torelli, Mario A Catanzaro, Nicola Nicolai, Patrizia Giannatempo, Andrea Necchi, Daniele Raggi, Biagio Paolini, Maurizio Colecchia, Luigi Piva, Davide Biasoni, Silvia Stagni, Antonio Tesone, Roberto Salvioni
BACKGROUND: Different approaches have been described in published studies for carcinoma in situ (CIS) of the glans penis (erythroplasia of Queyrat), including topical chemotherapy or immunotherapy and laser or surgical excision. We evaluated the efficacy of topical imiquimod (IQ) followed by carbon dioxide laser ablation of the lesion. PATIENTS AND METHODS: From 2010 to 2015, 10 patients affected by CIS of the glans were treated by IQ, followed by carbon dioxide laser ablation...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28154768/warty-carcinoma-penis-an-uncommon-variant
#17
Sushma Thapa, Arnab Ghosh, Santosh Shrestha, Dilasma Ghartimagar, Raghavan Narasimhan, O P Talwar
Penile carcinoma frequency varies widely in different parts of the world and comprises 1-10% of all the malignancies in males. Majority of the cases of penile carcinoma are squamous cell carcinoma of penis comprising 60% to 70% of all cases. Warty carcinoma of penis is an unusual neoplasm and a variant of penile squamous cell carcinoma comprising 5%-10% of all the variants. The other histological variants include basaloid, verrucous, papillary, sarcomatous, mixed, and adenosquamous carcinoma. The various histological entities with an exophytic papillary lesions including warty carcinoma are together referred to as the "verruciform" group of neoplasms...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28127189/sarcomatoid-carcinoma-of-the-penis
#18
Kiran Shankar, M Vijaya Kumar, C Srinivas, Sandeep Nayak, M N Suma
Sarcomatoid carcinomas are biphasic tumours, which occur at any site in the human body. It rarely affects the penis, with only 38 cases being reported in literature. It may be considered as a variant of squamous cell carcinoma or a dedifferentiated tumour. We report a 60-year old gentleman who presented with a swelling in the glans penis. He underwent a partial penectomy. Histopathology revealed sarcomatoid carcinoma of the penis, which was confirmed by immunohistochemistry. The rarity of this clinical entity makes its diagnosis difficult...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28096925/penile-metastasis-from-primary-transitional-cell-carcinoma-of-the-bladder-sparing-the-urethra
#19
Justin D Oake, Douglas N Drover
Metastatic involvement of the penis is relatively infrequent. Metastasis of transitional cell carcinoma (TCC) is extremely rare. We report a case of bladder TCC with metastases to the penis that spares the urethra - a finding that, to the best of our knowledge, has not been previously reported. Of the documented mechanisms of metastatic transmission to the penis, we suspect the cause was retrograde lymphatic spread. In our case, a 59-year-old male presented to our clinic initially with phimosis and later developed gross hematuria...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28076881/constitutive-nos-uncoupling-and-nadph-oxidase-upregulation-in-the-penis-of-type-2-diabetic-men-with-erectile-dysfunction
#20
B Musicki, A L Burnett
Erectile dysfunction (ED) associated with type 2 diabetes mellitus (T2DM) involves dysfunctional nitric oxide (NO) signaling and increased oxidative stress in the penis. However, the mechanisms of endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) dysregulation, and the sources of oxidative stress, are not well defined, particularly at the human level. The objective of this study was to define whether uncoupled eNOS and nNOS, and NADPH oxidase upregulation, contribute to the pathogenesis of ED in T2DM men...
March 2017: Andrology
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