Zhaomeng Wang, Yanhua Liu, Shuo Li, Fanlin Meng, Jiang Yu, Shuang Zhou, Songtao Dong, Jianying Ye, Lingxiao Li, Chuang Zhang, Shengnan Qiu, Guimei Lin, Hongzhuo Liu, Shyh-Dar Li, Zhonggui He, Yongjun Wang
Inspired by the natural phenomenon of phenolic-protein interactions, we translate this "naturally evolved interaction" to a "phenolic acid derivative based albumin bound" technology, through the synthesis of phenolic acid derivatives comprising a therapeutic cargo linked to a phenolic motif. Phenolic acid derivatives can bind to albumin and form nanocomplexes after microfluidic mixing. This strategy has been successfully applied to different types of anticancer drugs, including taxanes, anthraquinones, etoposides, and terpenoids...
December 15, 2022: Nano Letters