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https://www.readbyqxmd.com/read/28109284/development-of-plasmodium-falciparum-specific-na%C3%A3-ve-atypical-memory-and-plasma-b-cells-during-infancy-and-in-adults-in-an-endemic-area
#1
Allan Lugaajju, Sreenivasulu B Reddy, Mats Wahlgren, Fred Kironde, Kristina E M Persson
BACKGROUND: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown. RESULTS: Using the flow cytometry technique for detection of P. falciparum specific (Pf+) B-cells, this study for the first time measured the development of Pf+ B cell (CD19+) phenotypes in Ugandan babies from birth up to nine months, and in their mothers. The babies showed increases in Pf+ IgG memory B-cells (MBCs), atypical MBCs, and plasma cells/blasts over time, but the proportion of these cells were still lower than in the mothers who displayed stable levels (5, 18, and 3%, respectively)...
January 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28108351/response-to-letter-to-the-editor-by-a-huitfeldt-re-odds-ratios-deconstructed-a-new-way-to-understand-and-explain-odds-ratios-as-conditional-risk-ratios
#2
Fred M Hoppe, Daniel J Hoppe, Stephen D Walter
No abstract text is available yet for this article.
January 17, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28107789/open-access-platforms-in-spinal-cord-injury
#3
John L K Kramer, Fred Geisler, Leanne Ramer, Ward Plunet, Jacquelyn J Cragg
Recovery from acute spinal cord injury (SCI) is characterized by extensive heterogeneity, resulting in uncertain prognosis. Reliable prediction of recovery in the acute phase benefits patients and their families directly, as well as improves the likelihood of detecting efficacy in clinical trials. This issue of heterogeneity is not unique to SCI. In fields such as traumatic brain injury, Parkinson's disease, and amyotrophic lateral sclerosis, one approach to understand variability in recovery has been to make clinical trial data widely available to the greater research community...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28107226/evaluation-of-a-predictive-staging-model-for-hiv-associated-kaposi-sarcoma-in-uganda
#4
Fred Okuku, Elizabeth M Krantz, James Kafeero, Moses R Kamya, Jackson Orem, Corey Casper, Warren Phipps
BACKGROUND: HIV-associated Kaposi sarcoma (KS) is commonly staged using the AIDS Clinical Trials Group criteria, which classify 3 variables-- tumor extent (T), immune status (I), and systemic symptoms (S) - into good risk (0) and poor risk (1). Although validated in the US and Europe, these criteria have not been systematically evaluated in sub-Saharan Africa (SSA), where the burden of KS is greatest. METHODS: We reviewed medical charts of adult patients with HIV-associated KS seen at the Uganda Cancer Institute from 1992-2007...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28106794/a-thoroughly-validated-virtual-screening-strategy-for-discovery-of-novel-hdac3-inhibitors
#5
Huabin Hu, Jie Xia, Dongmei Wang, Xiang Simon Wang, Song Wu
Histone deacetylase 3 (HDAC3) has been recently identified as a potential target for the treatment of cancer and other diseases, such as chronic inflammation, neurodegenerative diseases, and diabetes. Virtual screening (VS) is currently a routine technique for hit identification, but its success depends on rational development of VS strategies. To facilitate this process, we applied our previously released benchmarking dataset, i.e., MUBD-HDAC3 to the evaluation of structure-based VS (SBVS) and ligand-based VS (LBVS) combinatorial approaches...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106744/oligonucleotide-therapy-for-obstructive-and-restrictive-respiratory-diseases
#6
REVIEW
Wupeng Liao, Jinrui Dong, Hong Yong Peh, Lay Hong Tan, Kah Suan Lim, Li Li, Wai-Shiu Fred Wong
Inhaled oligonucleotide is an emerging therapeutic modality for various common respiratory diseases, including obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD) and restrictive airway diseases like idiopathic pulmonary fibrosis (IPF). The advantage of direct accessibility for oligonucleotide molecules to the lung target sites, bypassing systemic administration, makes this therapeutic approach promising with minimized potential systemic side effects. Asthma, COPD, and IPF are common chronic respiratory diseases, characterized by persistent airway inflammation and dysregulated tissue repair and remodeling, although each individual disease has its unique etiology...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106492/editorial-concurrent-surgery
#7
Fred G Barker
No abstract text is available yet for this article.
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28104636/fred-flow-diverter-a-study-on-safety-and-efficacy-in-a-consecutive-group-of-50-patients
#8
H Luecking, T Engelhorn, S Lang, P Goelitz, S Kloska, K Roessler, A Doerfler
BACKGROUND AND PURPOSE: Endovascular flow diverters are increasingly used for the treatment of cerebral aneurysms. We assessed the safety and efficacy of the Flow-Redirection Endoluminal Device (FRED) in a consecutive series of 50 patients. MATERIALS AND METHODS: Inclusion criteria were wide-neck, blister-like, or fusiform/dissecting aneurysms independent of size, treated with the FRED between February 2014 and May 2015. Assessment criteria were aneurysm occlusion, manifest ischemic stroke, bleeding, or death...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28104262/editors-welcome
#9
EDITORIAL
Gavin Giovannoni, Chris Hawkes, Fred Lublin, Emmanuelle Waubant
No abstract text is available yet for this article.
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28103314/expression-of-a-mutant-sema3a-protein-with-diminished-signalling-capacity-does-not-alter-als-related-motor-decline-or-confer-changes-in-nmj-plasticity-after-botoxa-induced-paralysis-of-male-gastrocnemic-muscle
#10
Elizabeth B Moloney, Barbara Hobo, Fred De Winter, Joost Verhaagen
Terminal Schwann cells (TSCs) are specialized cells that envelop the motor nerve terminal, and play a role in the maintenance and regeneration of neuromuscular junctions (NMJs). The chemorepulsive protein semaphorin 3A (SEMA3A) is selectively up-regulated in TSCs on fast-fatigable muscle fibers following experimental denervation of the muscle (BotoxA-induced paralysis or crush injury to the sciatic nerve) or in the motor neuron disease amyotrophic lateral sclerosis (ALS). Re-expression of SEMA3A in this subset of TSCs is thought to play a role in the selective plasticity of nerve terminals as observed in ALS and following BotoxA-induced paralysis...
2017: PloS One
https://www.readbyqxmd.com/read/28101016/cellulitis-in-a-liver-transplant-patient-as-an-initial-manifestation-of-disseminated-cryptococcal-disease
#11
Marcos Davi Gomes de Sousa, Fred Bernardes Filho, Luís Eduardo Barros Costa Fernandes, Cássia Regina Guedes Leal, Cristiane Rocha Magalhães, Marcos Antonio Custódio Neto da Silva, Halime Silva Barcaui
A 50-year-old male underwent liver transplantation due to cryptogenic cirrhosis and was admitted with severe pain in the left leg as well as phlogosis. Amoxicillin/clavulanic acid was prescribed, assuming bullous erysipelas. Among the tests performed, the latex agglutination test for the Cryptococcus sp. antigen was positive, and in both the blood culture and blister culture Cryptococcus sp. was isolated. Daily fluconazole was started. Even though liposomal amphotericin B has been started on the fifth day of hospitalization, the patient progressed to death...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28099188/hepatitis-b-incidence-and-prevention-with-antiretroviral-therapy-among-hiv-positive-individuals-in-rakai-uganda
#12
Emmanuel Seremba, Victor Ssempijja, Sarah Kalibbala, Ronald H Gray, Maria J Wawer, Fred Nalugoda, Corey Casper, Warren T Phipps, Ponsiano Ocama, David Serwadda, David L Thomas, Steven Reynolds
OBJECTIVE: Antiretroviral therapy (ART) may interfere with replication of hepatitis B (HBV) raising the hypothesis that HBV infection might be prevented by ART. We investigated the incidence and risk factors associated with HBV among HIV-infected adults in Rakai, Uganda. METHODS: We screened stored sera from 944 HIV-infected adults enrolled in the Rakai Community Cohort Study between September 2003 and March 2015 for evidence of HBV exposure. Serum from participants who tested anti-HBc negative (497) at baseline were tested over 3-7 consecutive survey rounds for incident HBV...
January 17, 2017: AIDS
https://www.readbyqxmd.com/read/28098460/sulfate-mediated-end-to-end-assembly-of-gold-nanorods
#13
Seyyed Mohammad Hossein Abtahi, Nathan D Burrows, Fred A Idesis, Catherine J Murphy, Navid B Saleh, Peter J Vikesland
There is interest in the controlled aggregation of gold nanorods (GNRs) for the production of extended nanoassemblies. Prior studies have relied upon chemical modification of the GNR surface to achieve a desired final aggregate structure. Herein, we illustrate that control of electrolyte composition can facilitate end-to-end assembly of cetyltrimethylammonium bromide (CTAB) coated GNRs. By adjusting either the sulfate anion concentration or the exposure time it is possible to connect GNRs in chain-like assemblies...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28097490/glucose-uptake-and-triacylglycerol-synthesis-are-increased-in-barth-syndrome-lymphoblasts
#14
Edgard M Mejia, James C Zinko, Kristin D Hauff, Fred Y Xu, Amir Ravandi, Grant M Hatch
Barth syndrome (BTHS) is an X-linked genetic disease resulting in loss of cardiolipin (Ptd2Gro). Patients may be predisposed to hypoglycemia and exhibit increases in whole-body glucose disposal rates and a higher fat mass percentage. We examined the reasons for this in BTHS lymphoblasts. BTHS lymphoblasts exhibited a 60% increase (p < 0.004) in 2-[1,2-(3)H(N)]deoxy-D-glucose uptake, a 40% increase (p < 0.01) in glucose transporter-3 protein expression, an increase in phosphorylated-adenosine monophosphate kinase (AMPK) and a 58% increase (p < 0...
January 17, 2017: Lipids
https://www.readbyqxmd.com/read/28095727/mentor-mother-support-for-mothers-experiencing-intimate-partner-violence-in-family-practice-a-qualitative-study-of-three-different-perspectives-on-the-facilitators-and-barriers-of-implementation
#15
Maartje J W Loeffen, Jasper Daemen, Fred P J F Wester, Miranda G H Laurant, Sylvie H Lo Fo Wong, Antoine L M Lagro-Janssen
BACKGROUND: Intimate partner violence (IPV) is highly prevalent and associated with physical and mental health problems. Mentor mother support is a low threshold intervention in family practice consisting of support by non-professionals trained to support mothers experiencing IPV. A mentor mother support study showed reduced exposure to IPV and decreased symptoms of depression. OBJECTIVES: Identify factors determining implementation success of mentor mother support in family practice...
January 18, 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28093817/cryptic-inbreeding-depression-in-a-growing-population-of-a-long-lived-species
#16
Helen R Taylor, Rogan M Colbourne, Hugh A Robertson, Nicola J Nelson, Fred W Allendorf, Kristina M Ramstad
Genetic effects are often overlooked in endangered species monitoring, and populations showing positive growth are often assumed to be secure. However, the continued reproductive success of a few individuals may mask issues such as inbreeding depression, especially in long-lived species. Here, we test for inbreeding depression in little spotted kiwi (Apteryx owenii) by comparing a population founded with two birds to one founded with 40 birds, both from the same source population and both showing positive population growth...
January 17, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28093718/ribosomal-protein-s3-gene-silencing-protects-against-experimental-allergic-asthma
#17
Jinrui Dong, Wupeng Liao, Hong Yong Peh, Tze Khee Chan, W S Daniel Tan, Li Li, Amy Yong, W S Fred Wong
BACKGROUND AND PURPOSE: Ribosomal protein S3 (RPS3) is a 40S ribosomal protein of the S3P family essential for executing protein translation. RPS3 has recently been found to interact with the p65 subunit of the NF-κB complex, and promote p65 DNA-binding activity. Persistent activation of the NF-κB pathway is evident in allergic asthma. We hypothesized that gene silencing of lung RPS3 can ameliorate allergic airway inflammation. EXPERIMENTAL APPROACH: Gene silencing efficacy of RPS3 siRNA was screened in three different mouse cell lines by real-time PCR and immunoblotting...
January 17, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28092266/tgf-%C3%AE-reduces-dna-ds-break-repair-mechanisms-to-heighten-genetic-diversity-and-adaptability-of-cd44-cd24-cancer-cells
#18
Debjani Pal, Anja Pertot, Nitin H Shirole, Zhan Yao, Naishitha Anaparthy, Tyler Garvin, Hilary Cox, Kenneth Chang, Fred Rollins, Jude Kendall, Leyla Edwards, Vijay A Singh, Gary C Stone, Michael C Schatz, James Hicks, Gregory Hannon, Raffaella Sordella
Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanisms are cells characterized by a CD44+/CD24- cell surface marker profile. Here, we report that human CD44+/CD24- cancer cells are genetically highly unstable due to intrinsic defects in their DNA repair capabilities. In fact, in CD44+/CD24- cells constitutive activation of the TGF-beta axis was both necessary and sufficient to reduce the expression of genes that are critical in coordinating DNA damage repair mechanisms...
January 16, 2017: ELife
https://www.readbyqxmd.com/read/28091978/patient-specific-optimisation-of-administered-activity-and-acquisition-times-for-18-f-fdg-pet-imaging
#19
Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen, Thomas Wagner
BACKGROUND: The purpose of this study is to identify a method for optimising the administered activity and acquisition time for (18)F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes and compositions, while limiting radiation doses to patients and staff. Patients referred for FDG scans had bioimpedance measurements. They were injected with 3 MBq/kg of (18)F up to 370 MBq and scanned on a Siemens Biograph mCT at 3 or 4 min per bed position...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28090563/targeting-%C3%AE-v-integrins-in-pancreatic-fibrosis-progress-in-resolving-the-scar
#20
EDITORIAL
Chuhan Chung, Fred S Gorelick
No abstract text is available yet for this article.
July 2016: Cellular and Molecular Gastroenterology and Hepatology
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