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https://www.readbyqxmd.com/read/28944944/endovascular-treatment-of-intracranial-anterior-circulation-aneurysms-with-flow-diverters-a-single-centre-experience-with-mid-and-long-term-results
#1
Ezel Yaltirik Bilgin, Baran Önal, Hakan Emmez, Koray Akkan, Erhan Ilgit, Erkan Bilgin, Emetullah Cindil, Alp Ozgun Borcek
AIM: We report our experience with flow diverter devices in the treatment of intracranial aneurysms arising from anterior circulation with mid and long-term follow-up. MATERIAL AND METHODS: 78 aneurysms in 61 patients (range 25-81 years, 13 male, 48 female) were treated with flow diverter devices. 40 (51,3%) aneurysms were treated with pipeline embolization device (PED), 24 (30,8%) aneurysms were treated with SILK stent, 12(15,4%) aneurysms were treated with flow redirection endoluminal device (FRED) and two aneurysms were treated with P64 Flow Modulation Device (P64)...
July 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28941943/author-response-on-the-manuscript-titled-calling-order-to-chaos-treatment-decision-making-in-metastatic-castrate-resistant-prostate-cancer-url-d-17-01121
#2
Neal Shore, Axel Heidenreich, Fred Saad
No abstract text is available yet for this article.
September 20, 2017: Urology
https://www.readbyqxmd.com/read/28939857/sensing-bacterial-vibrations-and-early-response-to-antibiotics-with-phase-noise-of-a-resonant-crystal
#3
Ward L Johnson, Danielle Cook France, Nikki S Rentz, William T Cordell, Fred L Walls
The speed of conventional antimicrobial susceptibility testing (AST) is intrinsically limited by observation of cell colony growth, which can extend over days and allow bacterial infections to advance before effective antibiotics are identified. This report presents an approach for rapidly sensing mechanical fluctuations of bacteria and the effects of antibiotics on these fluctuations. Bacteria are adhered to a quartz crystal resonator in an electronic bridge that is driven by a high-stability frequency source...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939583/a-comparison-between-the-new-low-profile-visualized-intraluminal-support-lvis-blue-stent-and-the-flow-redirection-endoluminal-device-fred-in-bench-top-and-cadaver-studies
#4
Yoshikazu Matsuda, Joonho Chung, Kiffon Keigher, Demetrius Lopes
OBJECT: The aim of this study is to demonstrate the differences between the new Low-profile Visualized Intraluminal Support (LVIS Blue) stenting device and the Flow Redirection Endoluminal Device (FRED) using a series of bench-top evaluations and optical coherence tomography (OCT) images in a cadaveric preparation of the basilar artery. METHODS: The first part of the evaluation was bench-top microscopic documentation of metal coverage for LVIS Blue and FRED stents...
September 22, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28939223/stereotactic-radiosurgery-with-or-without-whole-brain-radiation-therapy-for-limited-brain-metastases-a-secondary-analysis-of-the-north-central-cancer-treatment-group-n0574-alliance-randomized-controlled-trial
#5
Thomas M Churilla, Karla V Ballman, Paul D Brown, Erin L Twohy, Kurt Jaeckle, Elana Farace, Jane H Cerhan, S Keith Anderson, Xiomara W Carrero, Yolanda I Garces, Fred G Barker, Richard Deming, Jesse G Dixon, Stuart H Burri, Caroline Chung, Cynthia Ménard, Volker W Stieber, Bruce E Pollock, Evanthia Galanis, Jan C Buckner, Anthony L Asher
PURPOSE: To determine whether whole-brain radiation therapy (WBRT) is associated with improved overall survival among non-small cell lung cancer (NSCLC) patients with favorable prognoses at diagnosis. METHODS AND MATERIALS: In the N0574 trial, patients with 1 to 3 brain metastases were randomized to receive stereotactic radiosurgery (SRS) or SRS plus WBRT (SRS + WBRT), with a primary endpoint of cognitive deterioration. We calculated diagnosis-specific graded prognostic assessment (DS-GPA) scores for NSCLC patients and evaluated overall survival according to receipt of WBRT and DS-GPA score using 2 separate cut-points (≥2...
August 5, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28938553/homocysteine-induced-peripheral-microcirculation-dysfunction-in-zebrafish-and-its-attenuation-by-l-arginine
#6
Sang Joon Lee, Sung Ho Park, Jinhyuk Fred Chung, Woorak Choi, Hyung Kyu Huh
Elevated blood homocysteine (Hcy) level is frequently observed in aged individuals and those with age-related vascular diseases. However, its effect on peripheral microcirculation is still not fully understood. Using in vivo zebrafish model, the degree of Hcy-induced peripheral microcirculation dysfunction is assessed in this study with a proposed dimensionless velocity parameter [Formula: see text], where [Formula: see text] and [Formula: see text] represent the peripheral microcirculation perfusion and the systemic perfusion levels, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938488/ovarian-aging-in-women-with-brca-germline-mutations
#7
Wayne Lin, Shiny Titus, Fred Moy, Elizabeth S Ginsburg, Kutluk Oktay
Context: Recent clinical and laboratory studies suggested that women with BRCA mutations have lower ovarian reserve and their primordial follicle oocytes may be more prone to DNA damage but the direct proof is lacking. Objective: To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage. Design: A laboratory comparative study of ovarian tissue obtained from the risk-reducing salpingo- oophorectomy (RRSO) samples of unaffected BRCA mutation carrier (BMC) women vs...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937434/th17-response-of-borderline-lepromatous-leprosy-inhibits-rash-manifestation-of-dapsone-hypersensitivity-syndrome-case-report
#8
Tamara de Nardo Vanzela, Fred Bernardes Filho, Carlos Gustavo Wambier, Francesca Maia Faria, Norma Tiraboschi Foss, Marco Andrey Cipriani Frade
BACKGROUND: Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. OBJECTIVE: Evaluation of immunological factors involved in the sparing of borderline-lepromatous (BL) leprosy patches by the severe exanthema related to DHS. METHODS: The authors describe a 19-year-old man with borderline-lepromatous leprosy with a recent diffuse rash, sparing only the hypochromic patches of leprosy, generalized lymphadenopathy, hepatomegaly, and jaundice 25 days after the start of multibacillary multidrug therapy...
September 11, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28937351/commentary-care-choice-and-the-ethical-imagination
#9
Fred B Ketchum
No abstract text is available yet for this article.
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28935965/aromatic-side-chain-conformational-switch-on-the-surface-of-the-rna-recognition-motif-enables-rna-discrimination
#10
Nana Diarra Dit Konté, Miroslav Krepl, Fred F Damberger, Nina Ripin, Olivier Duss, Jiří Šponer, Frédéric H-T Allain
The cyclooxygenase-2 is a pro-inflammatory and cancer marker, whose mRNA stability and translation is regulated by the CUG-binding protein 2 interacting with AU-rich sequences in the 3' untranslated region. Here, we present the solution NMR structure of CUG-binding protein 2 RRM3 in complex with 5'-UUUAA-3' originating from the COX-2 3'-UTR. We show that RRM3 uses the same binding surface and protein moieties to interact with AU- and UG-rich RNA motifs, binding with low and high affinity, respectively. Using NMR spectroscopy, isothermal titration calorimetry and molecular dynamics simulations, we demonstrate that distinct sub-states characterized by different aromatic side-chain conformations at the RNA-binding surface allow for high- or low-affinity binding with functional implications...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935577/human-pancreatic-acinar-cells-proteomic-characterization-physiologic-responses-and-organellar-disorders-in-ex-vivo-pancreatitis
#11
Aurelia Lugea, Richard T Waldron, Olga A Mareninova, Natalia Shalbueva, Nan Deng, Hsin-Yuan Su, Diane D Thomas, Elaina K Jones, Scott W Messenger, Jiayue Yang, Cheng Hu, Ilya Gukovsky, Zhenqiu Liu, Guy E Groblewski, Anna S Gukovskaya, Fred S Gorelick, Stephen J Pandol
Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis studies in human acini isolated from cadaveric pancreata from organ donors. Since data on these human acinar preparations are sparse, we assessed their functional integrity, and cellular and organellar morphology using light, fluorescence and electron microscopy; and their proteome by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28926120/glecaprevir-pibrentasvir-for-hcv-genotype-3-patients-with-cirrhosis-and-or-prior-treatment-experience-a-partially-randomized-phase-iii-clinical-trial
#12
David Wyles, Fred Poordad, Stanley Wang, Laurent Alric, Franco Felizarta, Paul Y Kwo, Benedict Maliakkal, Kosh Agarwal, Tarek Hassanein, Frank Weilert, Samuel S Lee, Jens Kort, Sandra S Lovell, Ran Liu, Chih-Wei Lin, Tami Pilot-Matias, Preethi Krishnan, Federico J Mensa
BACKGROUND: This study assessed the efficacy and safety of ribavirin (RBV)-free coformulated glecaprevir/pibrentasvir (G/P) in patients with hepatitis C virus (HCV) genotype (GT) 3 infection with either prior treatment experience and/or compensated cirrhosis, a patient population with limited treatment options. METHODS: SURVEYOR-II, Part 3 was a partially-randomized, open-label, multicenter, phase 3 study. Treatment-experienced (prior interferon (IFN) or pegIFN ± ribavirin or SOF plus ribavirin ± pegIFN therapy) patients without cirrhosis were randomized 1:1 to receive 12 or 16 weeks of G/P (300 mg/120 mg) once daily...
September 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28925987/the-public-cancer-radiology-imaging-collections-of-the-cancer-imaging-archive
#13
Fred Prior, Kirk Smith, Ashish Sharma, Justin Kirby, Lawrence Tarbox, Ken Clark, William Bennett, Tracy Nolan, John Freymann
The Cancer Imaging Archive (TCIA) is the U.S. National Cancer Institute's repository for cancer imaging and related information. TCIA contains 30.9 million radiology images representing data collected from approximately 37,568 subjects. This data is organized into collections by tumor-type with many collections also including analytic results or clinical data. TCIA staff carefully de-identify and curate all incoming collections prior to making the information available via web browser or programmatic interfaces...
September 19, 2017: Scientific Data
https://www.readbyqxmd.com/read/28921105/association-between-air-pollution-exposure-cognitive-and-adaptive-function-and-asd-severity-among-children-with-autism-spectrum-disorder
#14
Tara Kerin, Heather Volk, Weiyan Li, Fred Lurmann, Sandrah Eckel, Rob McConnell, Irva Hertz-Picciotto
Prenatal exposure to air pollution has been associated with autism spectrum disorder (ASD) risk but no study has examined associations with ASD severity or functioning. Cognitive ability, adaptive functioning, and ASD severity were assessed in 327 children with ASD from the Childhood Autism Risks from Genetics and the Environment study using the Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), and the Autism Diagnostic Observation Schedule calibrated severity score. Estimates of nitrogen dioxide (NO2), particulate matter (PM2...
September 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28920085/baseline-prescription-and-one-year-persistence-of-secondary-prevention-drugs-after-an-index-stroke-in-central-ghana
#15
Fred Stephen Sarfo, Bruce Ovbiagele, John Akassi, Gloria Kyem
BACKGROUND AND PURPOSE: There is a paucity of data on persistence of secondary prevention medications among stroke survivors in resource-limited settings where stroke is on a rapid upward trajectory and its management severely challenged. To avert new cardiovascular events after stroke, preventive medications should be promptly instituted and used continuously. We report 1-year rates and determinants of persistent utilization of secondary prevention therapies after stroke in Ghana. METHODS: A retrospective observational study involving 418 stroke survivors enrolled into a Neurology clinic in a tertiary institution in central Ghana between January 2011 and December 2013...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/28919727/five-year-durability-of-stand-alone-interspinous-process-decompression-for-lumbar-spinal-stenosis
#16
Pierce D Nunley, Vikas V Patel, Douglas G Orndorff, William F Lavelle, Jon E Block, Fred H Geisler
BACKGROUND: Lumbar spinal stenosis is the most common indication for spine surgery in older adults. Interspinous process decompression (IPD) using a stand-alone spacer that functions as an extension blocker offers a minimally invasive treatment option for intermittent neurogenic claudication associated with spinal stenosis. METHODS: This study evaluated the 5-year clinical outcomes for IPD (Superion(®)) from a randomized controlled US Food and Drug Administration (FDA) noninferiority trial...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28919379/2017-hrs-expert-consensus-statement-on-cardiovascular-implantable-electronic-device-lead-management-and-extraction
#17
Fred M Kusumoto, Mark H Schoenfeld, Bruce L Wilkoff, Charles I Berul, Ulrika M Birgersdotter-Green, Roger Carrillo, Yong-Mei Cha, Jude Clancy, Jean-Claude Deharo, Kenneth A Ellenbogen, Derek Exner, Ayman A Hussein, Charles Kennergren, Andrew Krahn, Richard Lee, Charles J Love, Ruth A Madden, Hector Alfredo Mazzetti, JoEllyn Carol Moore, Jeffrey Parsonnet, Kristen K Patton, Marc A Rozner, Kimberly A Selzman, Morio Shoda, Komandoor Srivathsan, Neil F Strathmore, Charles D Swerdlow, Christine Tompkins, Oussama Wazni
No abstract text is available yet for this article.
September 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28919367/nup153-interacts-with-sox2-to-enable-bimodal-gene-regulation-and-maintenance-of-neural-progenitor-cells
#18
Tomohisa Toda, Jonathan Y Hsu, Sara B Linker, Lauren Hu, Simon T Schafer, Jerome Mertens, Filipe V Jacinto, Martin W Hetzer, Fred H Gage
Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes...
September 13, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28918229/design-of-modified-botulinum-neurotoxin-a1-variants-with-a-shorter-persistence-of-paralysis-and-duration-of-action
#19
Daniel Scheps, Manuela López de la Paz, Marcel Jurk, Fred Hofmann, Jürgen Frevert
Botulinum neurotoxins (BoNTs) are classified by their antigenic properties into seven serotypes (A-G) and in addition by their corresponding subtypes. They are further characterized by divergent onset and duration of effect. Injections of low doses of botulinum neurotoxins cause localized muscle paralysis that is beneficial for the treatment of several medical disorders and aesthetic indications. Optimizing the therapeutic properties could offer new treatment opportunities. This report describes a rational design approach to modify the pharmacological properties by mutations in the C-terminus of BoNT/A1 light chain (LC)...
September 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28917559/predictors-and-outcomes-of-cardiac-resynchronization-therapy-extended-to-the-second-generator
#20
Xuping Li, Dachun Yang, Fred Kusumoto, Win-Guang Shen, Siva Mulpuru, Shenghua Zhou, Jinjun Liang, Gang Wu, Mei Yang, Jin-Qu Liu, Paul A Friedman, Yong-Mei Cha
BACKGROUND: A proportion of patients who receive cardiac resynchronization therapy (CRT) with defibrillator (CRT-D) live to receive a second generator. Controversy exists on whether an implantable cardioverter-defibrillator (ICD) should be offered to patients who have normalized or near normalized left ventricular ejection fraction (LVEF) at the time of generator replacement (GR). OBJECTIVE: To evaluate incidence of appropriate ICD therapy after CRT-D GR. METHODS: This series involved 1,026 consecutive patients who underwent CRT-D implant between January 2002 and December 2012...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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