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Late onset diabetes of the young

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https://www.readbyqxmd.com/read/29111600/mortality-and-acute-complications-in-children-and-young-adults-diagnosed-with-type-1-diabetes-in-yorkshire-uk-a-cohort-study
#1
T C Evans-Cheung, H J Bodansky, R C Parslow, R G Feltbower
AIMS: To examine all-cause and cause-specific mortality in a population-based cohort of people with early and late onset of Type 1 diabetes. METHODS: The Yorkshire Register of Diabetes in Children and Young People includes individuals with early (0-14 years) and late (1529 years) Type 1 diabetes onset, diagnosed between 1978 and 2013. This register was linked to death certification data from the Office for National Statistics to calculate standardized mortality ratios, cumulative mortality curves using Kaplan-Meier survival estimates, and Cox regression modelling...
November 7, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28945282/high-risk-of-conversion-to-diabetes-in-first-degree-relatives-of-individuals-with-young-onset-type-2-diabetes-a-12-year-follow-up-analysis
#2
Y Zhang, A O Y Luk, E Chow, G T C Ko, M H M Chan, M Ng, A P S Kong, R C W Ma, R Ozaki, W Y So, C C Chow, J C N Chan
AIM: Family history of diabetes is an established risk factor for Type 2 diabetes, but the impact of a family history of young-onset diabetes (onset < 40 years) on future risk of diabetes among first-degree relatives is unclear. In this prospective study, we examined the influence of family history of late- versus young-onset diabetes on the development of diabetes in a young to middle-aged Chinese population. METHODS: Some 365 siblings identified through probands with Type 2 diabetes and 452 participants from a community-based health awareness project (aged 18-55 years) who underwent metabolic assessment during the period 1998-2002 were followed to 2012-2013 to determine their glycaemic status...
September 25, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28941881/historical-evolution-of-ideas-on-eclampsia-preeclampsia-a-proposed-optimistic-view-of-preeclampsia
#3
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat, Marco Scioscia, Silvia Iacobelli, Thomas C Hulsey
Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000 years ago, we will make a brief presentation of the different major steps in comprehension of Pre-eclampsia. 1) 1840. Rayer, description of proteinuria in eclampsia, 2) 1897 Vaquez, discovery of gestational hypertension in eclamptic women, 3) In the 1970's, description of the "double" trophoblastic invasion existing only in humans (Brosens & Pijnenborg,), 4) between the 1970's and the 1990's, description of preeclampsia being a couple disease...
September 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28356037/markers-of-early-vascular-ageing
#4
Vasilios Kotsis, Christina Antza, Ioannis Doundoulakis, Stella Stabouli
BACKGROUND: Cardiovascular damage is clinically manifested as coronary artery disease, heart failure, stroke and peripheral artery disease. The prevalence of these adverse conditions is higher with advancing age. Although many patients present cardiovascular damage late in their life, it is common to see patients with early atherosclerosis in cardiovascular intensive care units at ages lower than 50 years in men and 55 for women. METHODS AND RESULTS: In this review of the literature we identified risk factors of early vascular damage...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28314946/late-onset-islet-autoimmunity-in-childhood-the-diabetes-autoimmunity-study-in-the-young-daisy
#5
Brigitte I Frohnert, Lisa Ide, Fran Dong, Anna E Barón, Andrea K Steck, Jill M Norris, Marian J Rewers
AIMS/HYPOTHESIS: We sought to assess the frequency, determinants and prognosis for future diabetes in individuals with islet autoimmunity and whether these factors differ depending on the age of onset of islet autoimmunity. METHODS: A prospective cohort (n = 2547) of children from the general population who had a high-risk HLA genotype and children who had a first-degree relative with type 1 diabetes were followed for up to 21 years. Those with the persistent presence of one or more islet autoantibodies were categorised as early-onset (<8 years of age, n = 143, median 3...
June 2017: Diabetologia
https://www.readbyqxmd.com/read/28281382/elevated-glycemia-and-brain-glucose-utilization-predict-bdnf-lowering-since-early-life
#6
Maria Angela Guzzardi, Elena Sanguinetti, Antonietta Bartoli, Alessandra Kemeny, Daniele Panetta, Piero A Salvadori, Silvia Burchielli, Patricia Iozzo
Obesity and diabetes associate with neurodegeneration. Brain glucose and BDNF are fundamental in perinatal development. BDNF is related to brain health, food intake and glucose metabolism. We characterized the relationship between glycemia and/or brain glucose utilization (by (18)FDG-PET during fasting and glucose loading), obesity and BDNF in 4-weeks old (pre-obese) and 12-weeks old (obese) Zucker fa/fa rats, and their age-matched fa/+ controls. In 75 human infants, we assessed cord blood BDNF and glucose levels, appetite regulating hormones, body weight and maternal factors...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27811505/early-and-late-complications-after-surgery-for-men1-related-nonfunctioning-pancreatic-neuroendocrine-tumors
#7
Sjoerd Nell, Inne H M Borel Rinkes, Helena M Verkooijen, Bert A Bonsing, Casper H van Eijck, Harry van Goor, Ruben H J de Kleine, Geert Kazemier, Elisabeth J Nieveen van Dijkum, Cornelis H C Dejong, Gerlof D Valk, Menno R Vriens
OBJECTIVE: To estimate short and long-term morbidity after pancreatic surgery for multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). BACKGROUND: Fifty percent of the MEN1 patients harbor multiple NF-pNETs. The decision to proceed to NF-pNET surgery is a balance between the risk of disease progression versus the risk of surgery-related morbidity. Currently, there are insufficient data on the surgical complications after MEN1 NF-pNET surgery...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27440110/rationale-and-design-of-the-randomised-controlled-trial-to-assess-the-impact-of-liraglutide-on-cardiac-function-and-structure-in-young-adults-with-type-2-diabetes-the-lydia-study
#8
RANDOMIZED CONTROLLED TRIAL
Z Z Htike, T Yates, E M Brady, D Webb, L J Gray, D Swarbrick, G P McCann, K Khunti, M J Davies
BACKGROUND: The prevalence of type 2 diabetes (T2DM) in younger adults is growing. Compared to the late onset T2DM, it is well recognized that the disease tends to behave more aggressively in the younger age group with evidence of premature micro and macrovasular diseases and shorter life span. This increased mortality is largely attributed to cardiovascular complications. In a recent pilot study, young adults with T2DM were found to have significantly lower peak diastolic strain rate (PEDSR) on cardiac MRI (CMR), a forerunner of diabetic cardiomyopathy...
July 21, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27432070/detecting-people-at-high-risk-of-type-2-diabetes-how-do-we-find-them-and-who-should-be-treated
#9
REVIEW
Alice P S Kong, Andrea O Y Luk, Juliana C N Chan
Diabetes is a chronic disease characterized by its silent and progressive nature. The prevalence of type 2 diabetes (T2DM) increases with age but with a worrying trend of increasingly young age of diagnosis. Compared to their counterparts with late onset of disease, these younger subjects face long disease duration with increased risk of diabetes-related complications. Besides, there is marked phenotypic heterogeneity which can interact with different interventions to give rise to variable clinical outcomes...
June 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27289208/analysis-of-mutations-in-the-glucokinase-gene-in-people-clinically-characterized-as-mody2-without-a-family-history-of-diabetes
#10
Ariel Pablo Lopez, Alejandro de Dios, Ignacio Chiesa, Maria Silvia Perez, Gustavo Daniel Frechtel
BACKGROUND: Maturity-onset diabetes of the young 2 (MODY2) is a form of diabetes that is clinically characterized by early age at onset and mild hyperglycemia, and has a low risk of late complications. It is often underdiagnosed due to its mild symptoms. To date, over 600 different GCK/MODY2 mutations have been reported. Despite only a few de novo mutations having been described, recent studies have reported the detection of a higher frequency of this kind of mutation. Therefore, de novo mutations could be more frequent than previously described...
August 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27215144/prevalence-of-sexual-dysfunction-and-associated-risk-factors-in-middle-aged-and-elderly-korean-men-in-primary-care
#11
Seo Young Kang, Jung Ah Lee, Sung Sunwoo, Byung-Yeon Yu, Jun Hyung Lee, Chung Hwan Cho, Byung-Wook Yoo, Tae Hee Jeon, Hoon Ki Park, Young Sik Kim
Although several studies have individually investigated the risk factors for erectile dysfunction (ED), premature ejaculation (PE), and late-onset hypogonadism (LOH), few studies have considered ED, PE, and LOH as categories of sexual dysfunction (SD) within the same population. We therefore aimed to investigate the prevalence of SD and its associated risk factors among men in primary care. Study participants were enrolled by 18 family physicians from 15 hospital-based family practices in Korea between August 2010 and May 2011...
November 2016: Journal of Sex Research
https://www.readbyqxmd.com/read/26981542/identification-of-hnf4a-mutation-p-t130i-and-hnf1a-mutations-p-i27l-and-p-s487n-in-a-han-chinese-family-with-early-onset-maternally-inherited-type-2-diabetes
#12
Ying Yang, Tai-Cheng Zhou, Yong-Ying Liu, Xiao Li, Wen-Xue Wang, David M Irwin, Ya-Ping Zhang
Maturity-onset diabetes of the young (MODY) is characterized by the onset of diabetes before the age of 25 years, positive family history, high genetic predisposition, monogenic mutations, and an autosomal dominant mode of inheritance. Here, we aimed to investigate the mutations and to characterize the phenotypes of a Han Chinese family with early-onset maternally inherited type 2 diabetes. Detailed clinical assessments and genetic screening for mutations in the HNF4α, GCK, HNF-1α, IPF-1, HNF1β, and NEUROD1 genes were carried out in this family...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26953591/factors-associated-with-delay-in-presentation-to-the-hospital-for-young-adults-with-ischemic-stroke
#13
Lester Y Leung, Louis R Caplan
OBJECTIVES: Young adults with ischemic stroke may present late to medical care, but the reasons for these delays are unknown. We sought to identify factors that predict delay in presentation. METHODS: We performed a retrospective cohort study of adults aged 18-50 admitted to a single academic medical center between 2007 and 2012. RESULTS: Eighty six of 141 (61%) young adults with ischemic stroke presented at the health center more than 4.5 h after stroke onset...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26947280/early-signs-of-atherogenesis-in-adolescents-in-a-havana-family-medicine-catchment-area
#14
Wendy Valdés, Georgia Díaz-Perera, Tania M Espinosa
INTRODUCTION Atherosclerosis is the common underlying cause of cardiovascular diseases; the leading cause of morbidity and mortality globally. It is a major contributor to disability and poorer quality of life and is costly to health systems, individuals, families and society. Early signs of atherogenesis are manifestations of atherosclerosis and known atherogenic risk factors occurring at young ages and detectable by health professionals. Early detection of such signs in children and adolescents enables actions to prevent short- and long-term complications...
October 2015: MEDICC Review
https://www.readbyqxmd.com/read/26834065/cardiovascular-disease-among-survivors-of-adult-onset-cancer-a-community-based-retrospective-cohort-study
#15
COMPARATIVE STUDY
Saro H Armenian, Lanfang Xu, Bonnie Ky, Canlan Sun, Leonardo T Farol, Sumanta Kumar Pal, Pamela S Douglas, Smita Bhatia, Chun Chao
PURPOSE: Cardiovascular diseases (CVDs), including ischemic heart disease, stroke, and heart failure, are well-established late effects of therapy in survivors of childhood and young adult (< 40 years at diagnosis) cancers; less is known regarding CVD in long-term survivors of adult-onset (≥ 40 years) cancer. METHODS: A retrospective cohort study design was used to describe the magnitude of CVD risk in 36,232 ≥ 2-year survivors of adult-onset cancer compared with matched (age, sex, and residential ZIP code) noncancer controls (n = 73,545) within a large integrated managed care organization...
April 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26778489/prevalence-of-comorbidity-in-patients-with-young-onset-alzheimer-disease-compared-with-late-onset-a-comparative-cohort-study
#16
COMPARATIVE STUDY
Adrie A J Gerritsen, Christian Bakker, Frans R J Verhey, Marjolein E de Vugt, René J F Melis, Raymond T C M Koopmans
OBJECTIVES: With the lack of a cure for Alzheimer disease (AD), the identification of comorbidity is important to reduce the possibility of excess disability. Although comorbidity in patients with late-onset AD (LO-AD) is common, for people with young-onset AD (YO-AD), it is unclear how often comorbidity occurs. Furthermore, it is uncertain whether comorbidity in patients with YO-AD differs from that in patients with LO-AD. The aim of this study was to explore the prevalence, types of morbidity, and morbidity profiles in patients with YO-AD compared with those of patients with LO-AD...
April 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/26305680/height-at-late-adolescence-and-incident-diabetes-among-young-men
#17
Ariel Furer, Arnon Afek, Zivan Beer, Estela Derazne, Dorit Tzur, Orit Pinhas-Hamiel, Brian Reichman, Gilad Twig
BACKGROUND: Short stature was suggested as a risk factor for diabetes onset among middle age individuals, but whether this is the case among young adults is unclear. Our goal was to assess the association between height and incident diabetes among young men. METHODS AND FINDINGS: Incident diabetes was assessed among 32,055 men with no history of diabetes, from the prospectively followed young adults of the MELANY cohort. Height was measured at two time points; at adolescence (mean age 17...
2015: PloS One
https://www.readbyqxmd.com/read/26271584/midterm-outcome-of-coronary-artery-bypass-grafting-in-young-patients-a-multicenter-italian-study
#18
MULTICENTER STUDY
Stefano Rosato, Fausto Biancari, Paola D'Errigo, Danilo Fusco, Fulvia Seccareccia
BACKGROUND: Myocardial revascularization in young patients should be durable enough to avoid new cardiovascular events or repeated revascularization procedures. The aim of this study was to evaluate the late outcomes of patients less than 50 years of age undergoing coronary artery bypass grafting (CABG) in comparison with older patients. METHODS: This study was a survival analysis of a pooled multicenter prospective cohort of patients who underwent CABG. RESULTS: Five percent of patients (572 of 11,087) were less than 50 years of age...
November 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26227404/demographic-and-clinical-characteristics-of-deaths-associated-with-influenza-a-h1n1-pdm09-in-central-america-and-dominican-republic-2009-2010
#19
Rafael Chacon, Sara Mirza, David Rodriguez, Antonio Paredes, Giselle Guzman, Lourdes Moreno, Cecilia J Then, Jorge Jara, Natalia Blanco, Luis Bonilla, Wilfrido A Clara, Percy Minaya, Rakhee Palekar, Eduardo Azziz-Baumgartner
BACKGROUND: The demographic characteristics of pandemic influenza decedents among middle and low-income tropical countries are poorly understood. We explored the demographics of persons who died with influenza A (H1N1)pdm09 infection during 2009-2010, in seven countries in the American tropics. METHODS: We used hospital-based surveillance to identify laboratory-confirmed influenza deaths in Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama and Dominican Republic...
2015: BMC Public Health
https://www.readbyqxmd.com/read/26215330/the-association-between-maternal-antioxidant-levels-in-midpregnancy-and-preeclampsia
#20
Jacqueline M Cohen, Michael S Kramer, Robert W Platt, Olga Basso, Rhobert W Evans, Susan R Kahn
OBJECTIVE: We sought to determine whether midpregnancy antioxidant levels are associated with preeclampsia, overall and by timing of onset. STUDY DESIGN: We carried out a case-control study, nested within a cohort of 5337 pregnant women in Montreal, Quebec, Canada. Blood samples obtained at 24-26 weeks were assayed for nonenzymatic antioxidant levels among cases of preeclampsia (n = 111) and unaffected controls (n = 441). We excluded women diagnosed with gestational hypertension only...
November 2015: American Journal of Obstetrics and Gynecology
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