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Late onset diabetes of the young

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https://www.readbyqxmd.com/read/27811505/early-and-late-complications-after-surgery-for-men1-related-nonfunctioning-pancreatic-neuroendocrine-tumors
#1
Sjoerd Nell, Inne H M Borel Rinkes, Helena M Verkooijen, Bert A Bonsing, Casper H van Eijck, Harry van Goor, Ruben H J de Kleine, Geert Kazemier, Elisabeth J Nieveen van Dijkum, Cornelis H C Dejong, Gerlof D Valk, Menno R Vriens
OBJECTIVE: To estimate short and long-term morbidity after pancreatic surgery for multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). BACKGROUND: Fifty percent of the MEN1 patients harbor multiple NF-pNETs. The decision to proceed to NF-pNET surgery is a balance between the risk of disease progression versus the risk of surgery-related morbidity. Currently, there are insufficient data on the surgical complications after MEN1 NF-pNET surgery...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27440110/rationale-and-design-of-the-randomised-controlled-trial-to-assess-the-impact-of-liraglutide-on-cardiac-function-and-structure-in-young-adults-with-type-2-diabetes-the-lydia-study
#2
Z Z Htike, T Yates, E M Brady, D Webb, L J Gray, D Swarbrick, G P McCann, K Khunti, M J Davies
BACKGROUND: The prevalence of type 2 diabetes (T2DM) in younger adults is growing. Compared to the late onset T2DM, it is well recognized that the disease tends to behave more aggressively in the younger age group with evidence of premature micro and macrovasular diseases and shorter life span. This increased mortality is largely attributed to cardiovascular complications. In a recent pilot study, young adults with T2DM were found to have significantly lower peak diastolic strain rate (PEDSR) on cardiac MRI (CMR), a forerunner of diabetic cardiomyopathy...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27432070/detecting-people-at-high-risk-of-type-2-diabetes-how-do-we-find-them-and-who-should-be-treated
#3
REVIEW
Alice P S Kong, Andrea O Y Luk, Juliana C N Chan
Diabetes is a chronic disease characterized by its silent and progressive nature. The prevalence of type 2 diabetes (T2DM) increases with age but with a worrying trend of increasingly young age of diagnosis. Compared to their counterparts with late onset of disease, these younger subjects face long disease duration with increased risk of diabetes-related complications. Besides, there is marked phenotypic heterogeneity which can interact with different interventions to give rise to variable clinical outcomes...
June 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27289208/analysis-of-mutations-in-the-glucokinase-gene-in-people-clinically-characterized-as-mody2-without-a-family-history-of-diabetes
#4
Ariel Pablo Lopez, Alejandro de Dios, Ignacio Chiesa, Maria Silvia Perez, Gustavo Daniel Frechtel
BACKGROUND: Maturity-onset diabetes of the young 2 (MODY2) is a form of diabetes that is clinically characterized by early age at onset and mild hyperglycemia, and has a low risk of late complications. It is often underdiagnosed due to its mild symptoms. To date, over 600 different GCK/MODY2 mutations have been reported. Despite only a few de novo mutations having been described, recent studies have reported the detection of a higher frequency of this kind of mutation. Therefore, de novo mutations could be more frequent than previously described...
December 0: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27215144/prevalence-of-sexual-dysfunction-and-associated-risk-factors-in-middle-aged-and-elderly-korean-men-in-primary-care
#5
Seo Young Kang, Jung Ah Lee, Sung Sunwoo, Byung-Yeon Yu, Jun Hyung Lee, Chung Hwan Cho, Byung-Wook Yoo, Tae Hee Jeon, Hoon Ki Park, Young Sik Kim
Although several studies have individually investigated the risk factors for erectile dysfunction (ED), premature ejaculation (PE), and late-onset hypogonadism (LOH), few studies have considered ED, PE, and LOH as categories of sexual dysfunction (SD) within the same population. We therefore aimed to investigate the prevalence of SD and its associated risk factors among men in primary care. Study participants were enrolled by 18 family physicians from 15 hospital-based family practices in Korea between August 2010 and May 2011...
May 23, 2016: Journal of Sex Research
https://www.readbyqxmd.com/read/26981542/identification-of-hnf4a-mutation-p-t130i-and-hnf1a-mutations-p-i27l-and-p-s487n-in-a-han-chinese-family-with-early-onset-maternally-inherited-type-2-diabetes
#6
Ying Yang, Tai-Cheng Zhou, Yong-Ying Liu, Xiao Li, Wen-Xue Wang, David M Irwin, Ya-Ping Zhang
Maturity-onset diabetes of the young (MODY) is characterized by the onset of diabetes before the age of 25 years, positive family history, high genetic predisposition, monogenic mutations, and an autosomal dominant mode of inheritance. Here, we aimed to investigate the mutations and to characterize the phenotypes of a Han Chinese family with early-onset maternally inherited type 2 diabetes. Detailed clinical assessments and genetic screening for mutations in the HNF4α, GCK, HNF-1α, IPF-1, HNF1β, and NEUROD1 genes were carried out in this family...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26953591/factors-associated-with-delay-in-presentation-to-the-hospital-for-young-adults-with-ischemic-stroke
#7
Lester Y Leung, Louis R Caplan
OBJECTIVES: Young adults with ischemic stroke may present late to medical care, but the reasons for these delays are unknown. We sought to identify factors that predict delay in presentation. METHODS: We performed a retrospective cohort study of adults aged 18-50 admitted to a single academic medical center between 2007 and 2012. RESULTS: Eighty six of 141 (61%) young adults with ischemic stroke presented at the health center more than 4.5 h after stroke onset...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26947280/early-signs-of-atherogenesis-in-adolescents-in-a-havana-family-medicine-catchment-area
#8
Wendy Valdés, Georgia Díaz-Perera, Tania M Espinosa
INTRODUCTION Atherosclerosis is the common underlying cause of cardiovascular diseases; the leading cause of morbidity and mortality globally. It is a major contributor to disability and poorer quality of life and is costly to health systems, individuals, families and society. Early signs of atherogenesis are manifestations of atherosclerosis and known atherogenic risk factors occurring at young ages and detectable by health professionals. Early detection of such signs in children and adolescents enables actions to prevent short- and long-term complications...
October 2015: MEDICC Review
https://www.readbyqxmd.com/read/26834065/cardiovascular-disease-among-survivors-of-adult-onset-cancer-a-community-based-retrospective-cohort-study
#9
COMPARATIVE STUDY
Saro H Armenian, Lanfang Xu, Bonnie Ky, Canlan Sun, Leonardo T Farol, Sumanta Kumar Pal, Pamela S Douglas, Smita Bhatia, Chun Chao
PURPOSE: Cardiovascular diseases (CVDs), including ischemic heart disease, stroke, and heart failure, are well-established late effects of therapy in survivors of childhood and young adult (< 40 years at diagnosis) cancers; less is known regarding CVD in long-term survivors of adult-onset (≥ 40 years) cancer. METHODS: A retrospective cohort study design was used to describe the magnitude of CVD risk in 36,232 ≥ 2-year survivors of adult-onset cancer compared with matched (age, sex, and residential ZIP code) noncancer controls (n = 73,545) within a large integrated managed care organization...
April 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26778489/prevalence-of-comorbidity-in-patients-with-young-onset-alzheimer-disease-compared-with-late-onset-a-comparative-cohort-study
#10
Adrie A J Gerritsen, Christian Bakker, Frans R J Verhey, Marjolein E de Vugt, René J F Melis, Raymond T C M Koopmans
OBJECTIVES: With the lack of a cure for Alzheimer disease (AD), the identification of comorbidity is important to reduce the possibility of excess disability. Although comorbidity in patients with late-onset AD (LO-AD) is common, for people with young-onset AD (YO-AD), it is unclear how often comorbidity occurs. Furthermore, it is uncertain whether comorbidity in patients with YO-AD differs from that in patients with LO-AD. The aim of this study was to explore the prevalence, types of morbidity, and morbidity profiles in patients with YO-AD compared with those of patients with LO-AD...
April 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/26305680/height-at-late-adolescence-and-incident-diabetes-among-young-men
#11
Ariel Furer, Arnon Afek, Zivan Beer, Estela Derazne, Dorit Tzur, Orit Pinhas-Hamiel, Brian Reichman, Gilad Twig
BACKGROUND: Short stature was suggested as a risk factor for diabetes onset among middle age individuals, but whether this is the case among young adults is unclear. Our goal was to assess the association between height and incident diabetes among young men. METHODS AND FINDINGS: Incident diabetes was assessed among 32,055 men with no history of diabetes, from the prospectively followed young adults of the MELANY cohort. Height was measured at two time points; at adolescence (mean age 17...
2015: PloS One
https://www.readbyqxmd.com/read/26271584/midterm-outcome-of-coronary-artery-bypass-grafting-in-young-patients-a-multicenter-italian-study
#12
MULTICENTER STUDY
Stefano Rosato, Fausto Biancari, Paola D'Errigo, Danilo Fusco, Fulvia Seccareccia
BACKGROUND: Myocardial revascularization in young patients should be durable enough to avoid new cardiovascular events or repeated revascularization procedures. The aim of this study was to evaluate the late outcomes of patients less than 50 years of age undergoing coronary artery bypass grafting (CABG) in comparison with older patients. METHODS: This study was a survival analysis of a pooled multicenter prospective cohort of patients who underwent CABG. RESULTS: Five percent of patients (572 of 11,087) were less than 50 years of age...
November 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26227404/demographic-and-clinical-characteristics-of-deaths-associated-with-influenza-a-h1n1-pdm09-in-central-america-and-dominican-republic-2009-2010
#13
Rafael Chacon, Sara Mirza, David Rodriguez, Antonio Paredes, Giselle Guzman, Lourdes Moreno, Cecilia J Then, Jorge Jara, Natalia Blanco, Luis Bonilla, Wilfrido A Clara, Percy Minaya, Rakhee Palekar, Eduardo Azziz-Baumgartner
BACKGROUND: The demographic characteristics of pandemic influenza decedents among middle and low-income tropical countries are poorly understood. We explored the demographics of persons who died with influenza A (H1N1)pdm09 infection during 2009-2010, in seven countries in the American tropics. METHODS: We used hospital-based surveillance to identify laboratory-confirmed influenza deaths in Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama and Dominican Republic...
2015: BMC Public Health
https://www.readbyqxmd.com/read/26215330/the-association-between-maternal-antioxidant-levels-in-midpregnancy-and-preeclampsia
#14
Jacqueline M Cohen, Michael S Kramer, Robert W Platt, Olga Basso, Rhobert W Evans, Susan R Kahn
OBJECTIVE: We sought to determine whether midpregnancy antioxidant levels are associated with preeclampsia, overall and by timing of onset. STUDY DESIGN: We carried out a case-control study, nested within a cohort of 5337 pregnant women in Montreal, Quebec, Canada. Blood samples obtained at 24-26 weeks were assayed for nonenzymatic antioxidant levels among cases of preeclampsia (n = 111) and unaffected controls (n = 441). We excluded women diagnosed with gestational hypertension only...
November 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26052646/risk-factors-for-surgical-site-infection-in-patients-undergoing-sacral-nerve-modulation-therapy
#15
Taylor Brueseke, Briana Livingston, Hussein Warda, Kathryn Osann, Karen Noblett
OBJECTIVES: The aim of this study was to identify risk factors for surgical site infection in patients undergoing sacral nerve modulation (SNM) surgery. METHODS: We conducted a retrospective cohort analysis of 290 patients undergoing a total of 669 SNM procedures between 2002 and 2012 by 2 fellowship-trained female pelvic medicine and reconstructive surgery attending physicians at the University of California-Irvine Medical Center. Infection was defined as a charted abnormal examination finding at the implantation site (erythema, induration, purulent discharge) resulting in prescription of antibiotics, hospitalization, or explantation...
July 2015: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/26014475/alteration-of-delta-like-ligand-1-and-notch-1-receptor-in-various-placental-disorders-with-special-reference-to-early-onset-preeclampsia
#16
Yota Shimanuki, Hiroyuki Mitomi, Yuki Fukumura, Shintaro Makino, Atsuo Itakura, Takashi Yao, Satoru Takeda
Notch signaling pathway has been shown to be dysregulated in placentas with preeclampsia, but there has been a lack of studies on methylation of Notch family genes in this disorder. We therefore executed methylation-specific polymerase chain reaction and immunostaining for Notch 1 receptor and the activating ligand, Delta-like (DLL) 1, with placental tissues from cases of preeclampsia (early onset, n = 18; late-onset, n = 19) and other placental disorders, including maternal complications such as diabetes mellitus and collagen disease (n = 10), fetal growth restriction (n = 17), fetal anomaly (n = 23), preterm birth (n = 15), miscarriage (n = 25), and hydatidiform moles (n = 9) as well as term births (n = 12)...
August 2015: Human Pathology
https://www.readbyqxmd.com/read/25924662/fibrocalculous-pancreatic-diabetes-a-case-report
#17
Dissanayake Mudiyanselage Priyantha Udaya Kumara Ralapanawa, Kushalee Poornima Jayawickreme, Ekanayake Mudiyanselage Madhushanka Ekanayake
BACKGROUND: Diabetes is now becoming a major cause of morbidity and mortality in both developing and developed countries. Even though type 1 and type 2 are the commonest, diabetes mellitus due to secondary causes have been identified. Fibrocalculous Pancreatic Diabetes is a unique entity wherein pancreatic calcification and chronic inflammation lead to exocrine and endocrine failure of the pancreas. This form of non-alcoholic pancreatopathy is exclusively seen among the young, with a male preponderance and commonly in tropical countries where malnutrition and poverty go hand in hand...
April 30, 2015: BMC Research Notes
https://www.readbyqxmd.com/read/25887359/eating-disorders-in-girls-and-women-with-type-1-diabetes-a-longitudinal-study-of-prevalence-onset-remission-and-recurrence
#18
Patricia A Colton, Marion P Olmsted, Denis Daneman, Jamie C Farquhar, Harmonie Wong, Stephanie Muskat, Gary M Rodin
OBJECTIVE: Girls and women with type 1 diabetes are at increased risk for developing eating disorders (EDs), and these disorders are associated with serious diabetes-related medical complications. This study describes the longitudinal course of disturbed eating behavior (DEB) and EDs in a cohort with type 1 diabetes. RESEARCH DESIGN AND METHODS: A total of 126 girls with type 1 diabetes receiving care for diabetes at The Hospital for Sick Children in Toronto participated in a series of seven interview-based assessments of ED behavior and psychopathology over a 14-year period, beginning in late childhood...
July 2015: Diabetes Care
https://www.readbyqxmd.com/read/25694217/effects-of-sitagliptin-on-counter-regulatory-and-incretin-hormones-during-acute-hypoglycaemia-in-patients-with-type-1-diabetes-a-randomized-double-blind-placebo-controlled-crossover-study
#19
RANDOMIZED CONTROLLED TRIAL
J E Schopman, J B L Hoekstra, B M Frier, M T Ackermans, J J J de Sonnaville, A M Stades, R Zwertbroek, B Hartmann, J J Holst, F K Knop, F Holleman
AIMS: To assess whether the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin affects glucagon and other counter-regulatory hormone responses to hypoglycaemia in patients with type 1 diabetes. METHODS: We conducted a single-centre, randomized, double-blind, placebo-controlled, three-period crossover study. We studied 16 male patients with type 1 diabetes aged 18-52 years, with a diabetes duration of 5-20 years and intact hypoglycaemia awareness. Participants received sitagliptin (100 mg/day) or placebo for 6 weeks and attended the hospital for three acute hypoglycaemia studies (at baseline, after sitagliptin treatment and after placebo)...
June 2015: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/25684977/ophthalmological-phenotype-associated-with-homozygous-null-mutation-in-the-neurod1-gene
#20
Orsolya Orosz, Miklós Czeglédi, Irén Kántor, István Balogh, Attila Vajas, Lili Takács, András Berta, Gergely Losonczy
PURPOSE: NEUROD1 is a tissue-specific basic helix loop helix (bHLH) protein involved in the development and maintenance of the endocrine pancreas and neuronal elements. Loss of NEUROD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. Heterozygous loss-of-function mutations in NEUROD1 have previously been described as a cause of maturity-onset diabetes of the young (MODY) and late-onset diabetes. To date, homozygous loss-of-function NEUROD1 mutations have only been detected in two patients...
2015: Molecular Vision
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