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https://www.readbyqxmd.com/read/29618721/risk-of-thrombosis-and-mortality-in-inflammatory-bowel-disease
#1
Adriana R Andrade, Luísa L Barros, Matheus F C Azevedo, Alexandre S Carlos, Aderson O M C Damião, Aytan M Sipahi, André Z A Leite
OBJECTIVES: Patients with inflammatory bowel disease have a higher risk of thrombosis, which is associated with a higher morbidity and mortality. Most data about VTE are related to hospitalized patients with active disease, but several cases happen in the outpatient setting, and are not covered by current prophylaxis recommendation. As the knowledge of VTE in outpatients is still poor, the aim of this study is to evaluate the risk, clinical data and mortality of thrombosis in patients followed in our center, comparing our findings with the current prophylaxis recommendation...
April 3, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29617306/development-of-colorectal-targeted-dietary-supplement-tablets-containing-natural-purple-rice-bran-oil-as-a-colorectal-chemopreventive
#2
Busaban Sirithunyalug, Chalermpong Saenjum, Suporn Charumanee, Bhagavathi Sundaram Sivamaruthi, Chaiyavat Chaiyasut, Jakkapan Sirithunyalug, Pratchaya Tipduangta
Colorectal cancer occurs due to various factors. The important risks are dietary lifestyle and inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. It has been found that the inhibitory enzyme cyclooxygenase-2 (COX-2) in the colorectal region can potentially reduce the risk of colorectal cancer. The present study investigated rice bran oil from natural purple rice bran, which exhibits antioxidant and anti-inflammatory activity. This study aimed to evaluate the bioactive compound content of natural purple rice bran oil (NPRBO) derived from native Thai purple rice and the anti-inflammatory activity of NPRBO in colorectal cancer cells, and to develop a colorectal delivery platform in the form of film-coated tablets...
April 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29610502/gingival-hyperplasia-as-a-presenting-symptom-of-crohn-s-disease-in-a-teenager
#3
N Hoogenes, S C Kommers, K H N de Boer, A L Görts, E A J M Schulten, T G J de Meij
No abstract text is available yet for this article.
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29606564/serum-concentrations-after-switching-from-originator-infliximab-to-the-biosimilar-ct-p13-in-patients-with-quiescent-inflammatory-bowel-disease-secure-an-open-label-multicentre-phase-4-non-inferiority-trial
#4
Anne S Strik, Wim van de Vrie, Joanne P J Bloemsaat-Minekus, Michael Nurmohamed, Peter J J Bossuyt, Alexander Bodelier, Theo Rispens, Yvonne J B van Megen, Geert R D'Haens
BACKGROUND: Biological treatment of chronic inflammatory diseases has improved patient outcomes but increased health-care costs. Switching patients from originator infliximab to a biosimilar can reduce costs, but prospective data about pharmacokinetics and potential immunogenicity are scarce. We aimed to show that infliximab serum concentrations with biosimilar CT-P13 are non-inferior to those with originator infliximab after switching from originator infliximab in patients with inflammatory bowel disease...
March 29, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29593342/genetic-variants-and-pathways-implicated-in-a-pediatric-inflammatory-bowel-disease-cohort
#5
Kelly A Shaw, David J Cutler, David Okou, Anne Dodd, Bruce J Aronow, Yael Haberman, Christine Stevens, Thomas D Walters, Anne Griffiths, Robert N Baldassano, Joshua D Noe, Jeffrey S Hyams, Wallace V Crandall, Barbara S Kirschner, Melvin B Heyman, Scott Snapper, Stephen Guthery, Marla C Dubinsky, Jason M Shapiro, Anthony R Otley, Mark Daly, Lee A Denson, Subra Kugathasan, Michael E Zwick
In the United States, approximately 5% of individuals with inflammatory bowel disease (IBD) are younger than 20 years old. Studies of pediatric cohorts can provide unique insights into genetic architecture of IBD, which includes Crohn's disease (CD) and ulcerative colitis (UC). Large genome-wide association studies have found more than 200 IBD-associated loci but explain a minority of disease variance for CD and UC. We sought to characterize the contribution of rare variants to disease development, comparing exome sequencing of 368 pediatric IBD patients to publicly available exome sequencing (dbGaP) and aggregate frequency data (ExAC)...
March 28, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29589539/paneth-cells-and-their-antimicrobials-in-intestinal-immunity
#6
Timon E Adolph, Lisa Mayr, Felix Grabherr, Herbert Tilg
Since the initial description of granular-rich small-intestinal crypt-based epithelial cells in 1872, today referred to as Paneth cells, a plethora of recent studies underlined their function in intestinal homeostasis. Paneth cells are evolutionary conserved highly secretory cells that produce antimicrobials to control gut microbial communities. Moreover, Paneth cells emerged as stem cell regulators that translate environmental cues into intestinal epithelial responses. Paneth cell disturbances may instigate intestinal inflammation and provide susceptibility to infection...
March 27, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29574823/active-matrixmetalloproteinase-8-and-periodontal-bacteria-interlink-between-periodontitis-and-inflammatory-bowel-disease
#7
J Schmidt, M Weigert, C Leuschner, H Hartmann, D Raddatz, R Haak, R F Mausberg, Tanja Kottmann, G Schmalz, D Ziebolz
BACKGROUND: The aim of this study was the investigation of concentration and prevalence of selected periodontal pathogenic bacteria and concentration of active matrix-metalloproteinase-8 (aMMP-8) within a group of patients with inflammatory bowel diseases (IBD) and to compare the results with a group of healthy control subjects (HC). METHODS: 59 IBD patients with Crohn`s disease (CD, n = 30) or ulcerative colitis (UC, n = 29) and 59 HC were included in this cross-sectional study...
March 25, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29569419/patients-with-perianal-crohn-s-fistulae-experience-delays-in-accessing-anti-tnf-therapy-due-to-slow-recognition-diagnosis-and-integration-of-specialist-services-lessons-learned-from-three-referral-centres
#8
Matthew J Lee, Clare Freer, Sam Adegbola, Soad Elkady, Miles Parkes, Ailsa Hart, Nicola S Fearnhead, Alan J Lobo, Steven R Brown
BACKGROUND: Crohn's anal fistula should be managed with a multidisciplinary team. There is no clearly defined 'patient pathway' from presentation to treatment. The aim of this study was to describe the patient route from presentation with symptomatic Crohn's anal fistula to starting anti-TNF therapy. METHOD: Case note review was undertaken at three hospitals with established IBD services. Patients with Crohn's anal fistula presenting between 2010 and 2015 were identified through clinical coding and local databases...
March 22, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29568200/-nod2-and-disease-specific-gene-expression-profiles-of-peripheral-blood-mononuclear-cells-from-crohn-s-disease-patients
#9
Holger Schäffler, Maria Rohde, Sarah Rohde, Astrid Huth, Nicole Gittel, Hannes Hollborn, Dirk Koczan, Änne Glass, Georg Lamprecht, Robert Jaster
AIM: To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells (PBMCs) from Crohn's disease (CD) patients in clinical remission. METHODS: Patients with CD in clinical remission or with very low disease activity according to the Crohn's disease activity index were genotyped regarding nucleotide-binding oligomerization domain 2 ( NOD2 ), and PBMCs from wild-type (WT)- NOD2 patients, patients with homozygous or heterozygous NOD2 mutations and healthy donors were isolated for further analysis...
March 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29564672/inflammatory-bowel-diseases-can-adversely-impact-domains-of-sexual-function-such-as-satisfaction-with-sex-life
#10
Swathi Eluri, Raymond K Cross, Christopher Martin, Kevin P Weinfurt, Kathryn E Flynn, Millie D Long, Wenli Chen, Kristen Anton, Robert S Sandler, Michael D Kappelman
BACKGROUND: Aspects of sexual health, which can be adversely affected by chronic disease, have been inadequately explored in inflammatory bowel disease (IBD). AIMS: We evaluated patient-reported interest in sexual activity and satisfaction with sex life in a large cohort of IBD patients. METHODS: We conducted a cross-sectional study within the Crohn's and Colitis Foundation Partners Internet cohort. Sequential participants completed a 6-question supplemental online survey to examine sexual interest and satisfaction using the Patient-Reported Outcome Measurement Information System® (PROMIS® ) Sexual Function and Satisfaction measures...
March 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29562278/network-medicine-a-mandatory-next-step-for-inflammatory-bowel-disease
#11
Heitor S P de Souza, Claudio Fiocchi
Despite unquestionable progress in the management of inflammatory bowel disease (IBD) and the much improved clinical results achievable today in Crohn's disease (CD) and ulcerative colitis (UC) patients, the overall therapeutic outcome remains far from optimal. The main reason of this partial success is that all current medications only block individual components of a highly complex disease process that results from the integration of multiple and incompletely identified pathogenic components. Thus, if further progress is to be achieved in IBD therapeutics and we want to move from the current success rate to nearly 100%, bold new ideas must be entertained and new approaches put into practice...
March 19, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29549998/acoustic-radiation-force-impulse-arfi-elastography-of-the-bowel-wall-as-a-possible-marker-of-inflammatory-activity-in-patients-with-crohn-s-disease
#12
R S Goertz, C Lueke, D Wildner, F Vitali, M F Neurath, D Strobel
AIM: To evaluate acoustic radiation force impulse (ARFI) shear-wave velocities of the bowel wall in patients with Crohn's disease (CD). MATERIAL AND METHODS: ARFI shear-wave elastography was analysed within the wall of the stomach, terminal ileum, and sigmoid, and correlated with ultrasound signs of activity in CD patients both retrospectively and in a prospective cohort. RESULTS: A total of 77 retrospective and 21 prospective CD patients were included...
March 14, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29546470/perioperative-outcomes-and-adverse-events-of-robotic-colorectal-resections-for-inflammatory-bowel-disease-a-systematic-literature-review
#13
REVIEW
S Renshaw, I L Silva, A Hotouras, S D Wexner, J Murphy, C Bhan
The purpose of this study was to assess outcome measures and cost-effectiveness of robotic colorectal resections in adult patients with inflammatory bowel disease. The Cochrane Library, PubMed/Medline and Embase databases were reviewed, using the text "robotic(s)" AND ("inflammatory bowel disease" OR "Crohn's" OR "Ulcerative Colitis"). Two investigators screened abstracts for eligibility. All English language full-text articles were reviewed for specified outcomes. Data were presented in a summarised and aggregate form, since the lack of higher-level evidence studies precluded meta-analysis...
March 15, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29543696/global-variation-in-use-of-enteral-nutrition-for-pediatric-crohn-disease
#14
Morgan Lawley, Jessica W Wu, Victor M Navas-López, Hien Q Huynh, Matthew W Carroll, Min Chen, Pavel Medvedev, Andrew S Day, Séamus Hussey, Rotem Sigall-Boneh, Arie Levine, Eytan Wine
OBJECTIVES: Exclusive enteral nutrition (EEN) is an effective induction treatment for pediatric Crohn disease. Given the center-based variation in use and diversity in practice we constructed a survey aimed at sharing experience and strategies in administering EEN, stimulating further research, and optimizing therapy. METHODS: This survey was constructed after consultation with experts and designed to address key knowledge gaps. The survey was disseminated through the Paediatric IBD Porto Group of ESPGHAN, Canadian Children IBD Network, selective experts, and was sent twice through the PEDGI-BB...
March 14, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29539644/interobserver-analysis-of-ceus-derived-perfusion-in-fibrotic-and-inflammatory-crohn-s-disease
#15
Kim Nylund, Fredrik Sævik, Sabine Leh, Frank Pfeffer, Trygve Hausken, Odd Helge Gilja
AIM:  To examine if there are perfusion differences in fibrotic versus inflammatory lesions in patients with Crohn's disease (CD) and to assess the interobserver reliability of the analysis. MATERIALS AND METHODS:  37 patients with Crohn's disease were prospectively recruited. 20 were operated and 18 of them had fibrotic disease. 17 received and were mostly responsive to medical treatment (14/17). Each patient underwent clinical scoring and ultrasound (US) examination with high-frequency linear transducers and US contrast...
March 14, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29535554/feasibility-of-salivary-dna-collection-in-a-population-based-case-control-study-a-pilot-study-of-pediatric-crohn-s-disease
#16
Michael D Kappelman, Aksel Lange, Rachel L Randell, Patricia V Basta, Robert S Sandler, Kristina Laugesen, Anna Byrjalsen, Tina Christensen, Trine Frøslev, Rune Erichsen
Background: Epidemiologic studies combining exposure and outcome data with the collection of biosamples are needed to study gene-environment interactions that might contribute to the etiology of complex diseases such as pediatric Crohn's disease (CD). Nationwide registries, including those in Denmark and other Scandinavian countries, provide efficient and reliable sources of data for epidemiological studies evaluating the environmental determinants of disease. We performed a pilot study to test the feasibility of collecting salivary DNA to augment registry data in established cases of pediatric CD and randomly selected, population-based controls...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29529008/explaining-interpatient-variability-in-adalimumab-pharmacokinetics-in-patients-with-crohn-s-disease
#17
Sophie E Berends, Anne S Strik, Juliet C Van Selm, Mark Löwenberg, Cyriel Y Ponsioen, Geert R DʼHaens, Ron A Mathôt
BACKGROUND: A significant proportion of patients with Crohn's disease (CD) require dose escalation or fail adalimumab (ADL) therapy over time. ADL, a monoclonal antibody directed against tumor necrosis factor, is approved for treatment of CD. Understanding pharmacokinetics (PK) of ADL is essential to optimize individual dosing in daily practice. The aim of this study was to evaluate PK of ADL in patients with CD and to identify factors that influence PK of ADL. METHODS: In a retrospective cohort study, the authors reviewed the charts of 96 patients with CD receiving ADL induction and maintenance treatment...
April 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29524254/mutilating-male-genital-crohn-s-without-gastrointestinal-involvement
#18
R T Winn, D Brass, S J Meggitt
A 58 year old gentleman developed multiple fissures and discharging sinuses in the groin and perineum. Skin biopsies showed non-caseating granulomas suggestive of Crohn's disease. The patient had no gastrointestinal symptoms and a radio-labelled white cell scan demonstrated no bowel involvement. This article is protected by copyright. All rights reserved.
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29521042/il-6-il-1%C3%AE-and-tnf-%C3%AE-only-in-combination-influence-the-osteoporotic-phenotype-in-crohn-s-patients-via-bone-formation-and-bone-resorption
#19
Martina Blaschke, Regine Koepp, Julia Cortis, Marina Komrakova, Matthias Schieker, Ute Hempel, Heide Siggelkow
BACKGROUND: Crohn´s disease (CD) is associated with a higher prevalence of osteoporosis. The pathogenesis of bone affliction remains controversial, especially if inflammatory cytokines or glucocorticoid therapy are the main contributors. In postmenopausal osteoporosis, bone resorption is induced by IL-6, IL-1β and TNF-α. In contrast, in children with CD, IL-6 exclusively decreased bone formation without affecting bone resorption. OBJECTIVES: The objective of this study was to further clarify the pathophysiology of bone affliction in adult patients with CD with the use of an osteoblast and osteoclast cell model...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29520605/opportunistic-screening-for-bone-disease-using-abdominal-ct-scans-obtained-for-other-reasons-in-newly-diagnosed-ibd-patients
#20
D Rebello, D Anjelly, D J Grand, J T Machan, M D Beland, M S Furman, J Shapiro, N LeLeiko, B E Sands, M Mallette, R Bright, H Moniz, M Merrick, S A Shah
Bone disease is prevalent among patients with inflammatory bowel disease (IBD), though bone density screening remains underutilized. We used CT scans performed for other indications in IBD patients to identify and monitor osteopenia using CT attenuation values at the lumbar spine. Significant rates of bone disease were detected which would have otherwise gone undiagnosed. INTRODUCTION: Osteoporosis affects about 14-42% of patients with IBD. Though screening is recommended in IBD patients with risk factors, it remains underutilized...
March 8, 2018: Osteoporosis International
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