keyword
MENU ▼
Read by QxMD icon Read
search

Crohn´s disease

keyword
https://www.readbyqxmd.com/read/28107278/impact-of-early-surgery-and-immunosuppression-on-crohn-s-disease-disabling-outcomes
#1
Fernando Magro, Cláudia C Dias, Rosa Coelho, Paula M Santos, Samuel Fernandes, Cidalina Caetano, Ângela Rodrigues, Francisco Portela, Ana Oliveira, Paula Ministro, Eugénia Cancela, Ana I Vieira, Rita Barosa, José Cotter, Pedro Carvalho, Isabelle Cremers, Daniel Trabulo, Paulo Caldeira, Artur Antunes, Isadora Rosa, Joana Moleiro, Paula Peixe, Rita Herculano, Raquel Gonçalves, Bruno Gonçalves, Helena Tavares Sousa, Luís Contente, Henrique Morna, Susana Lopes
BACKGROUND AND AIMS: The definition of early therapeutic strategies to control Crohn's disease aggressiveness and prevent recurrence is key to improve clinical practice. This study explores the impact of early surgery and immunosuppression onset in the occurrence of disabling outcomes. METHODS: This was a multicentric and retrospective study with 754 patients with Crohn's disease, who were stratified according to the need for an early surgery (group S) or not (group I) and further divided according to the time elapsed from the beginning of the follow-up to the start of immunosuppression therapy...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28105752/exclusive-enteral-nutrition-provides-an-effective-bridge-to-safer-interval-elective-surgery-for-adults-with-crohn-s-disease
#2
N Heerasing, B Thompson, P Hendy, G A Heap, G Walker, R Bethune, S Mansfield, C Calvert, N A Kennedy, T Ahmad, J R Goodhand
BACKGROUND: Few studies have reported the systematic use of exclusive enteral nutrition in the perioperative setting. AIMS: To test the hypothesis that exclusive enteral nutrition provides a safe and effective bridge to surgery and reduces post-operative complications, in adult patients with Crohn's disease requiring urgent surgery for stricturing or penetrating complications. METHODS: Patients treated with exclusive enteral nutrition prior to surgery were each matched with two control patients for disease behaviour, type of surgery, age at diagnosis and disease duration...
January 20, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28103724/the-effect-of-polymeric-formula-on-enterocyte-differentiation
#3
Gabrielle R Budd, Alan Aitchison, Andrew S Day, Jacqueline I Keenan
Exclusive enteral nutrition is established as an initial therapy to induce remission in active Crohn's disease (CD), especially in children, but the mechanisms of action of this therapy are yet to be fully defined. Intestinal alkaline phosphatase (IAP), a recognised marker of enterocyte differentiation, is implicated in the innate gut immune response to enteric pathogens. Using the Caco-2 human adenocarcinoma cell line, this study showed that the incubation of human cells with a polymeric formula (PF) resulted in a dose-dependent increase in the expression of IAP on the cell surface...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28099498/oral-tolerance-induced-by-ova-intake-ameliorates-tnbs-induced-colitis-in-mice
#4
Lisiery N Paiatto, Fernanda G D Silva, Julia Bier, Márcia R Brochetto-Braga, Áureo T Yamada, Wirla M S C Tamashiro, Patricia U Simioni
INTRODUCTION: Literature data have shown that the consumption of dietary proteins may cause modulatory effects on the host immune system, process denominated oral tolerance by bystander suppression. It has been shown that the bystander suppression induced by dietary proteins can improve inflammatory diseases such as experimental arthritis. Here, we evaluated the effects of oral tolerance induced by ingestion of ovalbumin (OVA) on TNBS-induced colitis in mice, an experimental model for human Crohn's disease...
2017: PloS One
https://www.readbyqxmd.com/read/28096726/diffusion-weighted-mr-enterography-to-monitor-bowel-inflammation-after-medical-therapy-in-crohn-s-disease-a-prospective-longitudinal-study
#5
Jimi Huh, Kyung Jo Kim, Seong Ho Park, So Hyun Park, Suk-Kyun Yang, Byong Duk Ye, Sang Hyoung Park, Kyunghwa Han, Ah Young Kim
OBJECTIVE: To prospectively evaluate the performance of diffusion-weighted imaging (DWI) to monitor bowel inflammation after medical therapy for Crohn's disease (CD). MATERIALS AND METHODS: Before and following 1-2 years of medical therapy, between October 2012 and May 2015, 18 randomly selected adult CD patients (male:female, 13:5; mean age ± SD, 25.8 ± 7.9 years at the time of enrollment) prospectively underwent MR enterography (MRE) including DWI (b = 900 s/mm(2)) and ileocolonoscopy...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28092308/increasing-incidence-of-crohn-s-disease-with-familial-clustering-in-the-kingdom-of-bahrain-a-25-year-population-based-study
#6
Najah R Zayyani, Hoda M Malaty, David Y Graham
BACKGROUND: The incidence of Crohn's disease has been increasing in developed countries; whether this trend has extended to countries in Middle East, especially in the Arab world, remains unclear. Our aim was to study the epidemiology, incidence, time trends and clustering of Crohn's disease within the population of the Kingdom of Bahrain. METHODS: A retrospective case-cohort study was conducted on patients diagnosed with Crohn's disease at Bahrain Specialist Hospital between 1990 and 2015...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28092305/prevalence-and-impact-of-inflammatory-bowel-disease-irritable-bowel-syndrome-on-patient-reported-outcomes-in-ccfa-partners
#7
Maisa I Abdalla, Robert S Sandler, Michael D Kappelman, Christopher F Martin, Wenli Chen, Kristen Anton, Millie D Long
BACKGROUND: Inflammatory bowel disease (IBD) patients with persistent symptoms despite no or minimal inflammation are frequently described as having an overlap of IBD and irritable bowel syndrome (IBD-IBS). Limited data are available on how IBS impacts the individual patient with IBD. In this study, we aimed to evaluate the prevalence of IBD-IBS and investigate its impact on patient-reported outcomes. METHOD: We performed a cross-sectional analysis within the CCFA Partners Study...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28072481/can-contrast-enhanced-sonography-detect-bowel-wall-fibrosis-in-mixed-inflammatory-and-fibrotic-crohn-disease-lesions-in-an-animal-model
#8
Jonathan R Dillman, Jonathan M Rubin, Laura A Johnson, David S Moons, Peter D R Higgins
OBJECTIVES: To determine whether contrast-enhanced sonographic quantitative perfusion parameters can detect bowel wall fibrosis in the setting of mixed inflammatory and fibrotic lesions in a Crohn disease animal model. METHODS: This study was approved by the institutional Committee on the Use and Care of Animals. Multiple (range, 1-5) 2,4,6-trinitrobenzenesulfonic acid-ethanol enemas were used to create intestinal inflammatory lesions with variable fibrosis in female Lewis rats...
January 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28069913/anti-tnf%C3%AE-antibody-induced-psoriasiform-skin-lesions-in-patients-with-inflammatory-bowel-disease-an-irish-cohort-study
#9
S Kirthi, A-M Tobin, M Hussey, F Scaldaferri, D McNamara
AIM: To determine the prevalence of psoriasis in an IBD cohort with reference to clinical characteristics and anti-TNFα use. METHODS: Patients with psoriasis and IBD were retrospectively identified from the IBD database at Tallaght Hospital from 2000 to 2015. Pertinent clinical data were obtained from patients notes including anti-TNFα exposure. Prevalence rates of genuine and reactive psoriasis were calculated and compared using a students T-test. A p value of < 0...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28068895/can-surgery-for-inflammatory-bowel-disease-be-personalized
#10
Antonino Spinelli, Alessandra Marano, Claudio Bacchelli, Nicolò Maria Mariani, Marco Montorsi, Paulo Gustavo Kotze
In the treatment of Inflammatory Bowel Diseases (IBD) despite advances in medical therapies, surgery has maintained a leading role in the management of complications of the disease, as well as in cases of failure of medical therapy. Surgery has become more and more minimally invasive, struggling for a difficult balance between guidelines and personalized treatment tailored on the single patient's need. In the present paper, the authors discuss the possible role for a personalization in debated fields of surgical treatment of Crohn&s disease and ulcerative colitis...
January 5, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28067059/il-23-blockade-for-crohn-s-disease-next-generation-of-anti-cytokine-therapy
#11
Federica Furfaro, Daniela Gilardi, Mariangela Allocca, Clelia Cicerone, Carmen Correale, Gionata Fiorino, Silvio Danese
Adaptive immunity in intestinal inflammation may play a key role in the pathogenesis of Crohn's disease. In particular, interleukin (IL)-23 may be a key mediator in chronic intestinal inflammation by inducing the differentiation of naïve CD4+ T cells into Th17, with the production of several pro-inflammatory cytokines. Furthermore, IL-23 induces interferon-γ (IFN- γ) production from activated T cells, a critical cytokine in innate and adaptive immunity against infections. Areas covered: We aim to review the available data from literature regarding the role of IL-23, with a more specific focus on the recent progresses in the therapeutic modulation of this cytokine...
January 9, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28057654/protocol-for-a-prospective-controlled-observational-study-to-evaluate-the-influence-of-hypoxia-on-healthy-volunteers-and-patients-with-inflammatory-bowel-disease-the-altitude-ibd-study
#12
Stephan Vavricka, Pedro A Ruiz, Sylvie Scharl, Luc Biedermann, Michael Scharl, Cheryl de Vallière, Carsten Lundby, Roland H Wenger, Leonhard Held, Tobias M Merz, Max Gassmann, Thomas Lutz, Andres Kunz, Denis Bron, Adriano Fontana, Laura Strauss, Achim Weber, Michael Fried, Gerhard Rogler, Jonas Zeitz
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic intestinal disorder, often leading to an impaired quality of life in affected patients. The importance of environmental factors in the pathogenesis of IBD, including their disease-modifying potential, is increasingly recognised. Hypoxia seems to be an important driver of inflammation, as has been reported by our group and others. The aim of the study is to evaluate if hypoxia can alter disease activity of IBD measured by Harvey-Bradshaw Activity Index in Crohn's disease (increase to ≥5 points) and the partial Mayo Score for ulcerative colitis (increase to ≥2 points)...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28045777/capillary-flow-rates-in-the-duodenum-of-pediatric-ulcerative-colitis-patients-are-increased-and-unrelated-to-inflammation
#13
Deenaz Zaidi, Lucas Churchill, Hien Q Huynh, Matthew W Carroll, Rabin Persad, Eytan Wine
BACKGROUND: Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are chronic pediatric disorders. Changes in vasculature are described in IBD but these could be secondary to inflammation and the role in pathogenesis is poorly understood. Assessing circulatory changes in typically unaffected sites in IBD (e.g., duodenum), when inflammation is absent, can identify vascular changes associated with pathogenesis. AIM: To measure capillary flow rates in duodenal mucosa using probe-based confocal laser endomicroscopy (pCLE) during endoscopy in children with IBD...
December 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28033681/high-endothelial-venules-associated-with-t-cell-subsets-in-the-inflamed-gut-of-newly-diagnosed-inflammatory-bowel-disease-patients
#14
Carmen S Horjus Talabur Horje, Carolijn Smids, Jos W R Meijer, Marcel J Groenen, Maaike K Rijnders, Ellen G van Lochem, Peter J Wahab
BACKGROUND: Naive and central memory T lymphocytes (TN and TCM ) can infiltrate the inflamed gut mucosa in Inflammatory Bowel Disease (IBD) patients. Homing of these subsets to the gut might be explained by ectopic formation of tertiary lymphoid organs (TLOs), containing high endothelial venules (HEVs). We aimed to evaluate the presence of HEVs and TLOs in inflamed intestinal mucosa of newly diagnosed, untreated, IBD patients in relation to the presence of TN and TCM lymphocytes. METHODS: IBD patients (n=39) and healthy controls (n=8) were prospectively included...
December 29, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28030510/clinical-and-fecal-microbial-changes-with-diet-therapy-in-active-inflammatory-bowel-disease
#15
David L Suskind, Stanley A Cohen, Mitchell J Brittnacher, Ghassan Wahbeh, Dale Lee, Michele L Shaffer, Kimberly Braly, Hillary S Hayden, Jani Klein, Benjamin Gold, Matthew Giefer, Angela Stallworth, Samuel I Miller
GOAL: To determine the effect of the specific carbohydrate diet (SCD) on active inflammatory bowel disease (IBD). BACKGROUND: IBD is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Diet is a potential therapeutic option for IBD based on the hypothesis that changing the fecal dysbiosis could decrease intestinal inflammation. STUDY: Pediatric patients with mild to moderate IBD defined by pediatric Crohn's disease activity index (PCDAI 10-45) or pediatric ulcerative colitis activity index (PUCAI 10-65) were enrolled into a prospective study of the SCD...
December 27, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28029742/functional-interaction-of-erap2-and-hla-b27-activates-the-unfolded-protein-response
#16
Zhenbo Zhang, Francesco Ciccia, Fanxing Zeng, Giuliana Guggino, Kirby Yee, Hasan Abdullah, Mark S Silverberg, Riccardo Alessandro, Giovanni Triolo, Nigil Haroon
OBJECTIVES: The basic mechanisms underlying ankylosing spondylitis (AS) pathogenesis remain unresolved. We previously reported an association of the single nucleotide polymorphisms (SNP) rs2549782 in Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with AS. It is known that patients homozygous for the G allele (GG) of another ERAP2 SNP rs2248374 have no ERAP2 expression (ERAP2-null). We utilized this information to study the impact of ERAP2 deficiency on HLA-B27 expression in AS patients...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28027825/inflammatory-bowel-disease-among-patients-with-psoriasis-treated-with-ixekizumab-a-presentation-of-adjudicated-data-from-an-integrated-database-of-7-randomized-controlled-and-uncontrolled-trials
#17
Kristian Reich, Craig Leonardi, Richard G Langley, Richard B Warren, Hervé Bachelez, Ricardo Romiti, Mamitaro Ohtsuki, Wen Xu, Nayan Acharya, Kathleen Solotkin, Jean-Frederic Colombel, Dana S Hardin
BACKGROUND: Inflammatory bowel disease (IBD) occurs more frequently in patients with psoriasis. The 2 diseases have significant genetic overlap, but the pathogenesis underlying their co-occurrence is unknown. OBJECTIVE: We sought to report adjudicated IBD cases (Crohn's disease [CD] and ulcerative colitis [UC]) in patients exposed to ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A. METHODS: Adverse events (AEs) integrated from 7 randomized controlled and uncontrolled trials were analyzed for the controlled induction period, controlled maintenance period, and all ixekizumab-treated patients...
December 24, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28013116/low-risk-of-pneumonia-from-pneumocystis-jirovecii-infection-in-patients-with-inflammatory-bowel-disease-receiving-immune-suppression
#18
Thomas G Cotter, Nicola Gathaiya, Jelena Catania, Edward V Loftus, William J Tremaine, Larry M Baddour, W Scott Harmsen, Alan R Zinsmeister, William J Sandborn, Andrew H Limper, Darrell S Pardi
BACKGROUND & AIMS: Use of immunosuppressants and inflammatory bowel disease (IBD) may increase the risk of pneumonia caused by Pneumocystis jirovecii (PJP). We assessed the risk of PJP in a population-based cohort of patients with IBD treated with corticosteroids, immune-suppressive medications, and biologics. METHODS: We performed a population-based cohort study of residents of Olmsted County, Minnesota, diagnosed with Crohn's disease (n=427) or ulcerative colitis (n=510) from 1970 through 2011...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28004853/ustekinumab-therapy-for-crohn-s-disease-during-pregnancy-a-case-report-and-review-of-the-literature
#19
X Cortes, J Borrás-Blasco, B Antequera, S Fernandez-Martinez, E Casterá, S Martin, J R Molés
WHAT IS KNOWN AND OBJECTIVES: The safety of continued ustekinumab (UST) therapy during pregnancy remains unclear in patients with Crohn's disease (CD). There are no meta-analysis reports of exposure to UST during pregnancy. The objective was to describe a case of a pregnant patient with CD who was successfully treated with UST maintenance therapy throughout the pregnancy and delivered a baby boy without any congenital malformations, neurological abnormalities or birth defects. CASE SUMMARY: A 37-year-old patient with CD treated with UST became pregnant...
December 22, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28003811/identification-and-characterization-of-a-novel-association-between-dietary-potassium-and-risk-of-crohn-s-disease-and-ulcerative-colitis
#20
Hamed Khalili, Sakshi Malik, Ashwin N Ananthakrishnan, John J Garber, Leslie M Higuchi, Amit Joshi, Joanna Peloquin, James M Richter, Kathleen O Stewart, Gary C Curhan, Amit Awasthi, Vijay Yajnik, Andrew T Chan
BACKGROUND: Recent animal studies have identified that dietary salt intake may modify the risk and progression of autoimmune disorders through modulation of the IL-23/TH17 pathway, which is critical in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD). METHODS: We conducted a prospective study of U.S. women enrolled in the Nurses' Health Study (NHS) and NHSII who provided detailed and validated information on diet and lifestyle beginning in 1984 in NHS and 1991 in NHSII...
2016: Frontiers in Immunology
keyword
keyword
115575
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"