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https://www.readbyqxmd.com/read/28239317/analysis-of-the-clinical-indications-for-opiate-use-in-inflammatory-bowel-disease
#1
Youran Gao, Sundas Khan, Meredith Akerman, Keith Sultan
BACKGROUND/AIMS: Opiate use for inflammatory bowel disease (IBD), particularly high-dose (HD) use, is associated with increased mortality. It's assumed that opiate use is directly related to IBD-related complaints, although this hasn't been well defined. Our goal was to determine the indications for opiate use as a first step in developing strategies to prevent or decrease opiate use. METHODS: A retrospective cohort was formed of adults who were diagnosed with IBD and for whom outpatient evaluations from 2009 to 2014 were documented...
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28230274/epidemiology-of-inflammatory-bowel-disease-among-participants-of-the-millennium-cohort-incidence-deployment-related-risk-factors-and-antecedent-episodes-of-infectious-gastroenteritis
#2
C K Porter, M Welsh, M S Riddle, C Nieh, E J Boyko, G Gackstetter, T I Hooper
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are two pathotypes of inflammatory bowel disease (IBD) with unique pathology, risk factors and significant morbidity. AIM: To estimate incidence and identify IBD risk factors in a US military population, a healthy subset of the US population, using information from the Millennium Cohort Study. METHODS: Incident IBD was identified from medical encounters from 2001 to 2009 or by self-report...
February 23, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28229470/the-incidence-of-inflammatory-bowel-disease-in-denmark-1980-2013-a-nationwide-cohort-study
#3
S N Lophaven, E Lynge, J Burisch
BACKGROUND: Globally, the incidence rates of inflammatory bowel disease (IBD) are increasing; however, data from high-incidence areas are conflicting. Previous studies in Denmark have assessed incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) using short observation periods. AIM: To investigate trends in IBD incidence in Denmark over a thirty-year period using nationwide data. METHODS: Patients diagnosed with CD or UC in Denmark between 1980 and 2013 were identified in the Danish National Patient Registry (NPR) and included in a nationwide cohort...
February 23, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28225051/low-muscle-mass-at-initiation-of-anti-tnf-therapy-for-inflammatory-bowel-disease-is-associated-with-early-treatment-failure-a-retrospective-analysis
#4
D Q Holt, P Varma, B J G Strauss, A S Rajadurai, G T Moore
BACKGROUND/OBJECTIVES: Delayed treatment failure occurs in a significant proportion of inflammatory bowel disease (IBD) patients treated with tumor necrosis factor-alpha (TNF) antagonists. Identification of predictors of loss of response (LOR) may help to optimize therapy. We sought to determine whether body composition parameters at the commencement of anti-TNF therapy were associated with earlier treatment failure. SUBJECTS/METHODS: A retrospective cohort study was performed on 68 patients who had undergone cross-sectional abdominal imaging coincident with the commencement of anti-TNF drugs...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28221248/early-transcriptomic-changes-in-the-ileal-pouch-provide-insight-into-the-molecular-pathogenesis-of-pouchitis-and-ulcerative-colitis
#5
Yong Huang, Sushila Dalal, Dionysios Antonopoulos, Nathaniel Hubert, Laura H Raffals, Kyle Dolan, Christopher Weber, Jeannette S Messer, Bana Jabri, Albert Bendelac, A Murat Eren, David T Rubin, Mitch Sogin, Eugene B Chang
BACKGROUND: Ulcerative colitis (UC) only involves the colonic mucosa. Yet, nearly 50% of patients with UC who undergo total proctocolectomy with ileal pouch anal anastomosis develop UC-like inflammation of the ileal pouch (pouchitis). By contrast, patients with familial adenomatous polyposis (FAP) with ileal pouch anal anastomosis develop pouchitis far less frequently. We hypothesized that pathogenic events associated with the development of UC are recapitulated by colonic-metaplastic transcriptomic reprogramming of the UC pouch...
March 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28204858/-ustekinumab-for-the-treatment-of-crohn-s-disease-uniti-im-uniti
#6
B Siegmund, S Nitschmann
No abstract text is available yet for this article.
February 15, 2017: Der Internist
https://www.readbyqxmd.com/read/28202666/lrrk2-in-peripheral-and-central-nervous-system-innate-immunity-its-link-to-parkinson-s-disease
#7
REVIEW
Heyne Lee, William S James, Sally A Cowley
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in familial and idiopathic cases of Parkinson's disease (PD), but are also associated with immune-related disorders, notably Crohn's disease and leprosy. Although the physiological function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in neurodegenerative diseases, including PD. Innate immunity involves macrophages and microglia, in which endogenous LRRK2 expression is precisely regulated and expression is strongly up-regulated upon cell activation...
February 8, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28198748/time-trends-in-the-epidemiology-and-outcome-of-perianal-fistulizing-crohn-s-disease-in-a-population-based-cohort
#8
Kevin W A Göttgens, Steven F G Jeuring, Rosel Sturkenboom, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Daisy M A E Jonkers, Laurents P S Stassen, Ad A M Masclee, Marieke J Pierik, Stéphanie O Breukink
OBJECTIVE: Perianal disease is a debilitating condition that frequently occurs in Crohn's disease (CD) patients. It is currently unknown whether its incidence has changed in the era of frequent immunomodulator use and biological availability. We studied the incidence and outcome of perianal and rectovaginal fistulas over the past two decades in our population-based Inflammatory Bowel Disease South-Limburg cohort. PATIENTS AND METHODS: All 1162 CD patients registered in the Inflammatory Bowel Disease South-Limburg registry were included...
February 14, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28198364/interleukin-22-drives-nitric-oxide-dependent-dna-damage-and-dysplasia-in-a-murine-model-of-colitis-associated-cancer
#9
C Wang, G Gong, A Sheh, S Muthupalani, E M Bryant, D A Puglisi, H Holcombe, E A Conaway, N A P Parry, V Bakthavatchalu, S P Short, C S Williams, G N Wogan, S R Tannenbaum, J G Fox, B H Horwitz
The risk of colon cancer is increased in patients with Crohn's disease and ulcerative colitis. Inflammation-induced DNA damage could be an important link between inflammation and cancer, although the pathways that link inflammation and DNA damage are incompletely defined. RAG2-deficient mice infected with Helicobacter hepaticus (Hh) develop colitis that progresses to lower bowel cancer. This process depends on nitric oxide (NO), a molecule with known mutagenic potential. We have previously hypothesized that production of NO by macrophages could be essential for Hh-driven carcinogenesis, however, whether Hh infection induces DNA damage in this model and whether this depends on NO has not been determined...
February 15, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28197769/confounding-effects-of-microbiome-on-the-susceptibility-of-tnfsf15-to-crohn-s-disease-in-the-ryukyu-islands
#10
Shigeki Nakagome, Hiroshi Chinen, Atsushi Iraha, Akira Hokama, Yasuaki Takeyama, Shotaro Sakisaka, Toshiyuki Matsui, Judith R Kidd, Kenneth K Kidd, Heba S Said, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Tsunehiko Hanihara, Ryosuke Kimura, Hajime Ishida, Jiro Fujita, Fukunori Kinjo, Shuhei Mano, Hiroki Oota
Crohn's disease (CD) involves chronic inflammation in the gastrointestinal tract due to dysregulation of the host immune response to the gut microbiome. Even though the host-microbiome interactions are likely contributors to the development of CD, a few studies have detected genetic variants that change bacterial compositions and increase CD risk. We focus on one of the well-replicated susceptible genes, tumor necrosis factor superfamily member 15 (TNFSF15), and apply statistical analyses for personal profiles of genotypes and salivary microbiota collected from CD cases and controls in the Ryukyu Islands, southernmost islands of the Japanese archipelago...
February 14, 2017: Human Genetics
https://www.readbyqxmd.com/read/28194815/peristomal-psoriasis
#11
C Marshall, S Woodmansey, C C Lyon
BACKGROUND: Psoriasis is a common skin condition, affecting 1.3-2.2% of the population. The prevalence of psoriasis has previously been reported as 11.2% in patients with Crohn disease (CD) and 5.7% in patients with ulcerative colitis. AIM: To assess the prevalence of psoriasis around stoma sites and identify the most effective treatment. METHODS: A departmental database of all patients attendings stoma clinic was accessed between 1 May 2003 and 15 October 2015...
February 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28193515/infliximab-not-associated-with-increased-risk-of-malignancy-or-hemophagocytic-lymphohistiocytosis-in-pediatric-patients-with-inflammatory-bowel-disease
#12
Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu
BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates and of malignancy and HLH in pediatric patients with IBD exposed to infliximab compared with patients not exposed to biologics and calculated standardized incidence ratios (SIRs). METHODS: We collected and analyzed data from 5766 participants in a prospective study of long-term outcomes of pediatric patients with IBD (NCT00606346), from 2007 through 30 June 2016...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28179509/iga-coated-e-coli-enriched-in-crohn-s-disease-spondyloarthritis-promote-th17-dependent-inflammation
#13
Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G Castellanos, Viola Woo, Fei Teng, Nhan L Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E Diehl, Nadim J Ajami, Joseph F Petrosino, Xi K Zhou, Sergio Schwartzman, Lisa A Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J Scherl, Hsin-Jung Joyce Wu, Kenneth W Simpson, Randy S Longman
Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with active inflammatory bowel disease (IBD) characterized by inflammatory enthesitis, dactylitis, or synovitis of nonaxial joints. However, a mechanistic understanding of the link between intestinal inflammation and SpA has yet to emerge. We evaluated and functionally characterized the fecal microbiome of IBD patients with or without peripheral SpA. Coupling the sorting of immunoglobulin A (IgA)-coated microbiota with 16S ribosomal RNA-based analysis (IgA-seq) revealed a selective enrichment in IgA-coated Escherichia coli in patients with Crohn's disease-associated SpA (CD-SpA) compared to CD alone...
February 8, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28176348/inflammatory-bowel-diseases-in-faroese-born-danish-residents-and-their-offspring-further-evidence-of-the-dominant-role-of-environmental-factors-in-ibd-development
#14
T Hammer, S N Lophaven, K R Nielsen, M von Euler-Chelpin, P Weihe, P Munkholm, J Burisch, E Lynge
BACKGROUND: The incidence of inflammatory bowel disease (IBD) is record high in the Faroe Islands, and many Faroese emigrate to Denmark, where the IBD incidence is considerably lower. AIM: To study the IBD incidence in first-, second- and third-generation immigrants from the Faroe Islands to Denmark to assess the extent to which the immigrants adopt the lower IBD incidence of their new home country. METHODS: Data on Faroese-born Danish residents and their children were retrieved from the Danish Central Population Register for 1980-2014...
February 8, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28175238/p666-short-term-outcomes-of-adalimumab-for-patients-with-crohn-s-disease-and-associated-prognostic-factors-a-multicentre-retrospective-cohort-study
#15
M Nasuno, H Tanaka, M Miyakawa, S Motoya, M Ishii, A Shiotani, M Yamashita, F Itoh, T Tanuma, R Sakemi, S So, R Suzuki, H Yanagisawa, K Onodera, H Kaneto, M Nojima, H Nakase
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175222/p730-disease-phenotype-of-korean-paediatric-crohn-s-disease-patients-at-diagnosis-a-multicentre-retrospective-comparative-study-with-eurokids
#16
B Kang, J-E Kim, S Kim, M J Kim, Y M Lee, J H Lee, J-H Lee, H J Lee, Y Lee, Y H Choe, B-H Choe
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175200/p637-anti-infliximab-antibody-concentrations-guide-therapeutic-decision-making-in-patients-with-crohn-s-disease-losing-clinical-response
#17
E Dreesen, T Van Stappen, V Ballet, S Tops, G Compernolle, G Van Assche, M Ferrante, S Vermeire, A Gils
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175198/p727-change-in-crohn-s-disease-behavior-in-a-prospective-european-population-based-inception-cohort-the-ecco-epicom-cohort
#18
J Burisch, J Halfvarson, L Kupcinskas, V Hernandez, I Kaimakliotis, D Valpiani, N Pedersen, D Duricova, L Kievit, J F Dahlerup, M Fumery, R Salupere, N Arebi, K R Nielsen, M Giannotta, P Oksanen, K H Katsanos, Z Vegh, P Ellul, D Schwartz, S Čuković-Čavka, R D'Incà, S Turcan, F Magro, A Goldis, E Langholz, P L Lakatos, P Munkholm
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175194/p669-adalimumab-long-term-effectiveness-in-adalimumab-na%C3%A3-ve-patients-with-crohn-s-disease-final-data-from-pyramid-registry
#19
E Loftus, G D'Haens, W Reinisch, J Satsangi, R Panaccione, S Berg, G Alperovich, M Bereswill, J Kalabic, M Skup, J Petersson, A M Robinson
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175179/p627-surrogate-markers-of-mucosal-healing-in-crohn-s-disease-patients-in-clinical-remission-under-biological-immunomodulator-treatment
#20
S Siakavellas, A Kostas, C Kosmidis, M Gizis, G Papatheodoridis, G Bamias
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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