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https://www.readbyqxmd.com/read/28732299/enterovesical-fistula-a-rare-complication-of-meckel-s-diverticulum-a-case-report
#1
Bourguiba M A, Gharbi M, Ghalleb M, Ben Taher A, Souai F, Bensafta Y, Sayari S, Ben Moussa M
INTRODUCTION: Enterovesical fistulas usually result from diverticulitis, Crohn's disease, or colorectal cancer. A perforated Meckel's diverticulum can exceptionally result in an vesico-diverticulum fistula, as noted in only seven previously reported cases. CASE REPORT: A 35-year old Arabic male, quadriplegic,who presented epigastralgia evolving for a week, associated with abdominal distension and cloudy urine. On examination he was feverish (38.5°C), dehydrated with tenderness in the entire distended abdomen; rectal examination revealed a hypotonic sphincter with no other abnormality...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28732137/prevalence-of-sacroiliitis-in-inflammatory-bowel-disease-using-a-standardized-ct-scoring-system
#2
Jonathan Chan, Ismail Sari, David Salonen, Mark S Silverberg, Nigil Haroon, Robert D Inman
OBJECTIVES: There is an increasing emphasis on early identification and treatment of ankylosing spondylitis (AS) of which the hallmark is sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk of AS and often receive CT scans of their abdomen affording clinicians the opportunity to determine the presence of sacroiliitis. Previous studies using CT have relied only on radiologist's gestalt or a non-validated adaptation of the mNY criteria. Our aim is to assess the prevalence of sacroiliitis in IBD using a validated screening tool and to determine how frequently these patients are referred for rheumatologic evaluation...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28727653/rising-incidence-of-paediatric-inflammatory-bowel-disease-in-canterbury-new-zealand-1996-2015
#3
Robert N Lopez, Laura Appleton, Richard B Gearry, Andrew S Day
BACKGROUND: The incidence of paediatric inflammatory bowel disease (IBD) around the world is increasing. Canterbury, New Zealand, has one of the highest Crohn's disease (CD) incidence rates published. This study aimed to document the incidence of paediatric IBD in Canterbury between 1996 and 2015. METHODS: All patients diagnosed with IBD in Canterbury, while under 16 years of age, between 1 January 1996 and 31 December 2015 were identified. Demographic and disease phenotypic details were collected and entered into a secure database...
July 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28724357/genome-analysis-of-e-coli-isolated-from-crohn-s-disease-patients
#4
Daria V Rakitina, Alexander I Manolov, Alexandra V Kanygina, Sofya K Garushyants, Julia P Baikova, Dmitry G Alexeev, Valentina G Ladygina, Elena S Kostryukova, Andrei K Larin, Tatiana A Semashko, Irina Y Karpova, Vladislav V Babenko, Ruzilya K Ismagilova, Sergei Y Malanin, Mikhail S Gelfand, Elena N Ilina, Roman B Gorodnichev, Eugenia S Lisitsyna, Gennady I Aleshkin, Petr L Scherbakov, Igor L Khalif, Marina V Shapina, Igor V Maev, Dmitry N Andreev, Vadim M Govorun
BACKGROUND: Escherichia coli (E. coli) has been increasingly implicated in the pathogenesis of Crohn's disease (CD). The phylogeny of E. coli isolated from Crohn's disease patients (CDEC) was controversial, and while genotyping results suggested heterogeneity, the sequenced strains of E. coli from CD patients were closely related. RESULTS: We performed the shotgun genome sequencing of 28 E. coli isolates from ten CD patients and compared genomes from these isolates with already published genomes of CD strains and other pathogenic and non-pathogenic strains...
July 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28719595/risk-of-postoperative-complications-among-inflammatory-bowel-disease-patients-treated-preoperatively-with-vedolizumab
#5
Akihiro Yamada, Yuga Komaki, Nayan Patel, Fukiko Komaki, Arthur S Aelvoet, Anthony L Tran, Joel Pekow, Sushila Dalal, Russell D Cohen, Lisa Cannon, Konstantin Umanskiy, Radhika Smith, Roger Hurst, Neil Hyman, David T Rubin, Atsushi Sakuraba
OBJECTIVES: Vedolizumab is increasingly used to treat patients with ulcerative colitis (UC) and Crohn's disease (CD), however, its safety during the perioperative period remains unclear. We compared the 30-day postoperative complications among patients treated preoperatively with vedolizumab, anti-tumor necrosis factor (TNF)-α agents or non-biological therapy. METHODS: The retrospective study cohort was comprised of patients receiving vedolizumab, anti-TNF-α agents or non-biological therapy within 4 weeks of surgery...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28719543/the-association-between-maternal-chronic-inflammatory-bowel-disease-and-long-term-health-outcomes-in-children-a-nationwide-cohort-study
#6
Line R Jølving, Jan Nielsen, Signe S Beck-Nielsen, Rasmus G Nielsen, Sonia Friedman, Ulrik S Kesmodel, Bente M Nørgård
BACKGROUND: Very little is known about the long-term impact of maternal inflammatory bowel disease (IBD) on the offspring's future health. We aimed to examine whether children born to mothers with IBD had an increased risk of long-term morbidities. METHODS: In this nationwide register-based cohort study, including all children born alive in Denmark between 1989 and 2013, we investigated the association between maternal IBD and 15 selected disease categories of physical and mental conditions in the offspring...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28700535/vitamin-d-status-is-associated-with-hepcidin-and-hemoglobin-concentrations-in-children-with-inflammatory-bowel-disease
#7
Sana Syed, Ellen S Michalski, Vin Tangpricha, Supavit Chesdachai, Archana Kumar, Jarod Prince, Thomas R Ziegler, Parminder S Suchdev, Subra Kugathasan
BACKGROUND: Anemia, iron deficiency, and hypovitaminosis D are well-known comorbidities in inflammatory bowel disease (IBD). Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines. METHODS: We aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia in pediatric IBD...
July 11, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28694133/ectopic-pregnancy-in-women-with-inflammatory-bowel-disease-a-22-year-nationwide-cohort-study
#8
Punyanganie S de Silva, Helene H Hansen, Sonja Wehberg, Sonia Friedman, Bente M Nørgård
BACKGROUND & AIMS: Data on early adverse pregnancy outcomes in inflammatory bowel disease (IBD) such as ectopic pregnancy (EP) remain limited. We assessed the risk of EP in pregnancies of Danish women with IBD compared to all other Danish women over a 22-year period. In addition, we examined the disease-specific risk of EP in pregnancies of women with ulcerative colitis (UC) or Crohn's disease (CD) who underwent IBD-related surgical procedures. METHODS: We obtained nationwide data in all women of child-bearing age who had at least one pregnancy resulting in either an EP, hydatiform mole, induced abortion, miscarriage, or live birth from January 1994 through 2015...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28694130/bowel-damage-in-patients-with-long-term-crohn-s-disease-assessed-by-magnetic-resonance-enterography-and-the-lemann-index
#9
Aida Kapic Lunder, Jørgen Jahnsen, Linda Tøften Bakstad, Arne Borthne, Johannes Roksund Hov, Morten Vatn, Anne Negård
BACKGROUND AND AIMS: Magnetic Resonance Enterography (MRE) is used to evaluate the extent and complications of Crohn's disease (CD) and has recently been included in a score for bowel damage, the Lemann Index (LI). The long-term outcomes of CD are still uncertain and we aimed to assess the structural bowel changes after 20 years of CD by means of MRE and LI score. METHODS: We performed a follow-up analysis of a population-based cohort of 237 patients in southeastern Norway diagnosed with CD from 1990 through 1993...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28689150/association-of-urinary-phenolic-compounds-inflammatory-bowel-disease-and-chronic-diarrheal-symptoms-evidence-from-the-national-health-and-nutrition-examination-survey
#10
Punyanganie S de Silva, Xuan Yang, Joshua R Korzenik, Rose H Goldman, Kristopher L Arheart, Alberto J Caban-Martinez
Endocrine disruptors such as phenolic compounds and parabens may be involved in chronic non-infective disease. While products incorporating these compounds are extensively utilized in consumer and personal products, little is known about their effect on bowel health. Inflammatory bowel disease (IBD) - consisting of the diseases ulcerative colitis and Crohn's disease - and irritable bowel syndrome are common chronic non-infectious diarrheal diseases. Despite limited knowledge on the etiology of IBD, these diseases have increased prevalence in industrialized countries and cause significant impairment to quality of life...
July 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28685527/elevated-levels-of-il-2-and-il-21-produced-by-cd4-t-cells-in-inflammatory-bowel-disease
#11
S Ebrahimpour, M Shahbazi, A Khalili, M T Tahoori, A Zavaran Hosseini, A Amari, B Aghili, S Abediankenari, H Mohammadizad, M Mohammadnia-Afrouzi
CD4+ T cells are considered as a subset of cells that play a pivotal role in the development of inflammatory bowel disease (IBD). The aim of this study was to assess the levels of interleukin (IL)-2, IL-21 and their receptors produced by CD4+ T cells in patients with inflammatory bowel disease. Thirty-two patients with ulcerative colitis (UC) and mean age of 37.93±10.37 years, as well as 22 patients with Crohn’s disease (CD) and mean age of 37.04±10.44 years, were studied. The healthy controls (HC) included 31 subjects with a mean age of 36...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28677060/assessment-of-patency-capsule-retention-using-mr-diffusion-weighted-imaging
#12
Eyal Klang, Uri Kopylov, Shomron Ben-Horin, Adi Lahat, Doron Yablecovitch, Noa Rozendorn, Rami Eliakim, Michal Marianne Amitai
OBJECTIVES: Evaluate the ability of MR diffusion-weighted imaging (DWI) to predict patency capsule retention in Crohn's disease (CD). METHODS: Clinical and imaging data were prospectively reviewed for 80 CD patients following patency capsule administration and MR-DWI under institutional review board (IRB) approval with informed consent. Two radiologists separately assessed the presence/absence of restricted diffusion in the distal ileum. Apparent diffusion coefficients (ADC) from three regions of interest on the ileal wall were averaged...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28668353/salsa-a-dance-on-a-slippery-floor-with-changing-partners
#13
M P Reichhardt, U Holmskov, S Meri
It is becoming increasingly clear that the connections between our immune system and the microbiota colonizing us have a tremendous impact on human health. A number of innate molecular defence mechanisms cooperate to selectively target unwanted microorganisms at the mucosal surfaces. Amongst others these include the complement system, IgA and the SALSA molecule. The salivary scavenger and agglutinin (SALSA), also known as deleted in malignant brain tumors 1 (DMBT1), salivary agglutinin (SAG) or gp340 is a multifunctional molecule with important functions in innate immunity, inflammation and epithelial homeostasis...
June 28, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28668336/the-nod2-smoking-interaction-in-crohn-s-disease-is-likely-specific-to-the-1007fs-mutation-and-may-be-explained-by-age-at-diagnosis-a-meta-analysis-and-case-only-study
#14
M Ellen Kuenzig, Jeff Yim, Stephanie Coward, Bertus Eksteen, Cynthia H Seow, Cheryl Barnabe, Herman W Barkema, Mark S Silverberg, Peter L Lakatos, Paul L Beck, Richard Fedorak, Levinus A Dieleman, Karen Madsen, Remo Panaccione, Subrata Ghosh, Gilaad G Kaplan
BACKGROUND: NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at diagnosis on NOD2-smoking interactions (Phase 2). METHODS: Phase 1: MEDLINE and EMBASE were searched for studies (n=18) providing data on NOD2 and smoking in Crohn's disease. NOD2-smoking interactions were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) calculated using random effects models...
June 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28667429/long-term-clinical-outcomes-after-switching-from-remicade-%C3%A2-to-biosimilar-ct-p13-in-inflammatory-bowel-disease
#15
Lisa J T Smits, Anna Grelack, Lauranne A A P Derikx, Dirk J de Jong, Aura A J van Esch, Ronald S Boshuizen, Joost P H Drenth, Frank Hoentjen
BACKGROUND: Limited data are available on long-term clinical outcomes regarding the switch from Remicade(®) to the infliximab biosimilar CT-P13 in inflammatory bowel disease (IBD) patients. AIMS: To investigate long-term efficacy, safety, pharmacokinetic profile, and immunogenicity. METHODS: We performed a single-center prospective observational cohort study following an elective switch from Remicade(®) to CT-P13 in IBD patients. RESULTS: Eighty-three patients were included (57 Crohn's disease, 24 ulcerative colitis, and 2 IBD unclassified), and 68 patients completed one-year follow-up...
June 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28666696/vulvar-crohn-s-a-rare-presentation-of-crohn-s-disease
#16
Sarah T Cigna, Leia S Mitchell, Andrew T Goldstein
No abstract text is available yet for this article.
June 27, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28664992/the-outcome-of-ulcerative-colitis-patients-undergoing-pouch-surgery-is-determined-by-pre-surgical-factors
#17
H Yanai, S Ben-Shachar, L Mlynarsky, L Godny, M Leshno, H Tulchinsky, I Dotan
BACKGROUND: Pouch surgery, a common intervention for ulcerative colitis (UC) complications, is often associated with the development of pouchitis. AIM: To identify predictors of pouch outcome in a cohort of patients with UC. METHODS: We conducted a retrospective unmatched case-cohort study in a tertiary IBD referral centre. Adult patients with UC were classified into the worst phenotype throughout follow-up: normal pouch, a form of chronic pouchitis (either chronic pouchitis or Crohn's like disease of pouch [CLDP]), or episodic recurrent acute pouchitis (RAP)...
June 30, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28664835/prevalence-and-significance-of-anti-saccharomyces-cerevisiae-antibodies-in-primary-sj%C3%A3-gren-s-syndrome
#18
Alessia Alunno, Onelia Bistoni, Francesco Carubbi, Valentina Valentini, Giacomo Cafaro, Elena Bartoloni Bocci, Roberto Giacomelli, Roberto Gerli
OBJECTIVES: Saccharomyces cerevisiae is a common yeast used in the food industry. IgG and IgA antibodies against the phosphopeptidomannan of the S. cerevisiae cell wall (ASCA) are a well known marker of disease severity in Crohn's disease. Moreover, a number of studies assessed ASCA in several systemic and organ-specific autoimmune diseases postulating molecular mimicry as a possible link between ASCA and autoimmunity. However, since they have never been tested in primary Sjögren's syndrome (pSS), the purpose of this study was to investigate these antibodies in a large cohort of pSS patients, compared to healthy donors (HD), and their significance as potentially helpful biomarker in a clinical setting...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28653753/the-development-of-a-magnetic-resonance-imaging-index-for-fistulising-crohn-s-disease
#19
M A Samaan, C A J Puylaert, B G Levesque, G Y Zou, L Stitt, S A Taylor, L M Shackelton, M K Vandervoort, R Khanna, C Santillan, J Rimola, P Hindryckx, C Y Nio, W J Sandborn, G D'Haens, B G Feagan, V Jairath, J Stoker
BACKGROUND: Magnetic resonance imaging (MRI) is the gold standard for assessment of perianal fistulising Crohn's disease (CD). The Van Assche index is the most commonly used MRI fistula index. AIMS: To assess the reliability of the Van Assche index, and to modify the instrument to improve reliability and create a novel index for fistulising CD. METHODS: A consensus process developed scoring conventions for existing Van Assche index component items and new items...
June 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28651829/evaluation-of-a-12-week-targeted-vitamin-d-supplementation-regimen-in-patients-with-active-inflammatory-bowel-disease
#20
Mayur Garg, Ourania Rosella, Gennaro Rosella, Yunqiu Wu, John S Lubel, Peter R Gibson
BACKGROUND & AIMS: Vitamin D at serum 25(OH)D concentrations above 100 nmol/L is associated with disease remission in patients with IBD, suggesting targeted dosing might be anti-inflammatory. This study aimed to assess the effectiveness, safety and predictors of a 12-week regimen of vitamin D supplementation to achieve such a target in patients with active disease. METHODS: In a pilot study, patients with active colitis and a serum 25(OH)D concentration <75 nmol/L were prescribed oral liquid vitamin D supplementation over 12 weeks using a specific protocol with dose adjusted 4-weekly to aim for a target level of 100-125 nmol/L...
June 15, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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