Livia Casciola-Rosen, David R Thiemann, Felipe Andrade, Maria I Trejo-Zambrano, Elissa K Leonard, Jamie B Spangler, Nicole E Skinner, Justin Bailey, Srinivasan Yegnasubramanian, Rulin Wang, Ajay M Vaghasia, Anuj Gupta, Andrea L Cox, Stuart C Ray, Raleigh M Linville, Zhaobin Guo, Peter C Searson, Carolyn E Machamer, Stephen Desiderio, Lauren M Sauer, Oliver Laeyendecker, Brian T Garibaldi, Li Gao, Mahendra Damarla, Paul M Hassoun, Jody E Hooper, Christopher A Mecoli, Lisa Christopher-Stine, Laura Gutierrez-Alamillo, Qingyuan Yang, David Hines, William A Clarke, Richard E Rothman, Andrew Pekosz, Katherine Zj Fenstermacher, Zitong Wang, Scott L Zeger, Antony Rosen
BACKGROUND: COVID-19 is a global pandemic caused by the novel coronavirus SARS-CoV-2. Some clinical features of severe COVID-19 represent blood vessel damage induced by activation of host immune responses, initiated by the virus. We hypothesized that autoantibodies against angiotensin converting enzyme-2 (ACE2), the SARS-CoV-2 receptor expressed on vascular endothelium, are generated during COVID-19, and are of mechanistic importance. METHODS: The study was done in an opportunity sample of 118 COVID-19 inpatients...
March 29, 2022: JCI Insight