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https://www.readbyqxmd.com/read/29895311/epithelial-disruption-a-new-paradigm-enabling-human-airway-stem-cell-transplantation
#1
Nigel Farrow, Patricia Cmielewski, Martin Donnelley, Nathan Rout-Pitt, Yuben Moodley, Ivan Bertoncello, David Parsons
BACKGROUND: Airway disease is a primary cause of morbidity and early mortality for patients with cystic fibrosis (CF). Cell transplantation therapy has proven successful for treating immune disorders and may have the potential to correct the airway disease phenotype associated with CF. Since in vivo cell delivery into unconditioned mouse airways leads to inefficient engraftment, we hypothesised that disrupting the epithelial cell layer using the agent polidocanol (PDOC) would facilitate effective transplantation of cultured stem cells in mouse nasal airways...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29882287/ultrasound-guided-microfoam-sclerotherapy-with-polidocanol-for-symptomatic-giant-hepatic-cyst-initial-experience
#2
Yuji Eso, Akihiro Furuta, Atsushi Takai, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
AIM: In cases of symptomatic giant hepatic cysts, appropriate treatment is required to relieve symptoms. Ethanol, minocycline hydrochloride, and ethanolamine oleate have been conventionally used for ultrasound (US)-guided sclerotherapy. However, liquid sclerosing agents could mix with the residual fluid in the cyst and reduce their sclerotic effects. We performed US-guided microfoam sclerotherapy using polidocanol for three patients and evaluated its efficacy and safety. METHODS: Between May 2016 and March 2017, three female patients with symptomatic giant hepatic cysts were referred to our hospital...
June 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29871533/effects-of-sulodexide-on-stability-of-sclerosing-foams
#3
Costantino Davide Critello, Antonino S Fiorillo, Maria Chiara Cristiano, Stefano de Franciscis, Raffaele Serra
Background and objectives Foam sclerotherapy is a clinical procedure for the treatment of unhealthy veins. The aim of this study was to investigate the effect of sulodexide (SUL) on stability of foams prepared using polidocanol (POL) and sodium tetradecyl sulfate (STS) detergents, more specifically with 0.25% aethoxysclerol and 0.2% Fibro-Vein sclerosing solutions. Methods Foams were produced by the Tessari method using three different weight ratios of POL-SUL and STS-SUL (1:0, 1:1, and 1:3). Results The half-life of STS foams resulted as follows: 82 ± 1...
January 1, 2018: Phlebology
https://www.readbyqxmd.com/read/29850938/intramuscular-venous-malformations-of-the-upper-and-lower-limbs-indications-and-outcomes-of-sclerotherapy
#4
Giuseppe Bianchini, Daniele Camilli, Sergio Furgiuele
PURPOSE: Multiple treatment options have been described for intramuscular venous malformations (VMs) of the limbs. At the current time, there are no clear management guidelines. The aim was to evaluate efficacy and safety of sclerotherapy in this type of VMs. MATERIALS AND METHODS: This is a single-center, retrospective review of patients treated for extremity intramuscular VMs between January 2013 and June 2017. The primary outcomes were the improvement of symptoms self-assessed by questionnaires, and the reduction in VM size measured by magnetic resonance (MRI)...
May 30, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29846340/subcutaneous-injection-of-large-volumes-of-polidocanol
#5
Fabian Schibler, Luca Borradori, Albert-Adrien Ramelet
No abstract text is available yet for this article.
May 24, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29800302/novel-treatment-of-prepatellar-bursitis
#6
Charles H Parker, Jeffrey C Leggit
A 31-yr-old soldier presented with an 8-mo history of right prepatellar bursitis with 1-mo history of pain and loss of range of motion. His symptoms did not respond to activity modification, compression, nonsteroidal anti-inflammatory agents, or repeated aspirations with fenestration. After thorough discussion, the soldier and his provider reviewed the literature and found a single case report of intrabursal sclerotherapy in two patients with recalcitrant prepatellar bursitis. After informed consent, the patient wished to proceed with the scelerotherapy...
May 24, 2018: Military Medicine
https://www.readbyqxmd.com/read/29772321/use-of-polidocanol-endovenous-microfoam-to-improve-hemodynamics-and-symptomology-in-patients-with-challenging-clinical-presentations-a-case-series
#7
Paul E Davis, John Phillips, Raghu Kolluri
BACKGROUND: We performed a retrospective review of treatment effects with FDA-approved Polidocanol endovenous microfoam (PEM, Varithena® 1%) on venous symptomology in ten (N=10) C3-C6 patients with chronic venous insufficiency (CVI) and concomitant complex disease/pathology that limited the use of endothermal ablation (ETA). METHODS: Pathology included: risk of bruising or bleeding, severe lipodermatosclerosis (LDS), Hydradenitis Suppurativa, chronic fibrosis of the vein from prior superficial thrombosis, risk for nerve injury and failed prior ETA...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29614554/-effect-of-foam-sclerotherapy-for-the-treatment-of-oropharyngeal-venous-malformation
#8
C Q Niu, H Jiang, S Y Zhou, G Shen, H B Li, J Zhang
Objective: To evaluate the safety and efficacy of foam sclerotherapy with polidocanol for the treatment of venous malformation in the oropharynx. Methods: The clinical data of 21 children with venous malformation in the oropharynx treated by foam sclerotherapy were retrospectively analyzed. There were 10 males and 11 females, ranging in age from 1 month to 13 years, with a median age of 2.3 years. MRI was performed in all children, and the diagnosis was further confirmed by radiography. After general anesthesia, the oropharynx was exposed by opening device...
March 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29489686/a-gastrointestinal-stromal-tumor-with-acute-bleeding-management-and-nursing
#9
Xiuju Shi, Shuxia Yu, Fenyan Wang, Qi Zhao, Hongwei Xu, Bin Li
RATIONALE: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors involving the gastrointestinal tract. A small percentage of GISTs may cause acute gastrointestinal bleeding, which requires urgent surgical intervention. PATIENT CONCERNS: In this case report, we present a 62-year-old male patient with who was hospitalized due to acute bleeding. DIAGNOSES: The patient was diagnosed as GIST with low risk. INTERVENTIONS: The patient was treated endoscopically with polidocanol sclerotherapy...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29473522/an-evidence-based-review-of-off-label-uses-of-polidocanol
#10
Seyyed Reza Sadat Ebrahimi, Elgar Enamzadeh, Hossein Babaei
BACKGROUND: Polidocanol is approved for its competence in the treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. OBJECTIVE: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis and hemorrhoids...
2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29417264/polidocanol-sclerotherapy-combined-with-transarterial-embolization-using-n-butyl-cyanoacrylate-for-extracranial-arteriovenous-malformations
#11
Akira Kitagawa, Takahiro Yamamoto, Nozomu Matsunaga, Mayako Yamaji, Shuji Ikeda, Yuichiro Izumi, Makiyo Hagihara, Toyohiro Ota, Tsuneo Ishiguchi
PURPOSE: To assess the safety and effectiveness of polidocanol sclerotherapy combined with transarterial embolization using a liquid adhesive agent (n-butyl cyanoacrylate, NBCA) for treatment of extracranial arteriovenous malformations (AVMs). MATERIALS AND METHODS: Twenty-three patients with symptomatic AVMs in the head and neck (6), upper (7) and lower extremity (10) with a mean age of 42 years (range 4-74) treated with polidocanol sclerotherapy were retrospectively assessed...
February 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29241409/letter-re-evaluation-of-sodium-tetradecyl-sulfate-and-polidocanol-as-sclerosants-for-leg-telangiectasia-based-on-histological-evaluation-with-clinical-correlation
#12
https://www.readbyqxmd.com/read/29241408/response-to-professor-whitely-concerning-evaluation-of-sodium-tetradecyl-sulfate-and-polidocanol-as-sclerosants-for-leg-telangiectasia-based-on-histological-evaluation-with-clinical-correlation
#13
https://www.readbyqxmd.com/read/29219197/comparison-of-ultrasound-guided-percutaneous-polidocanol-injection-versus-percutaneous-ethanol-injection-for-treatment-of-benign-cystic-thyroid-nodules
#14
Xiaohua Gong, Fang Wang, Haiyan Du, Xiaojun Chen, Bimin Shi
OBJECTIVES: We compared the efficacy, safety, and cost-effectiveness of ultrasound-guided percutaneous polidocanol injection and percutaneous ethanol injection for the treatment of benign cystic and predominantly cystic thyroid nodules. METHODS: A total of 135 cystic thyroid nodules treated by percutaneous ethanol injection and 136 cystic thyroid nodules treated by percutaneous polidocanol injection were enrolled retrospectively in this study from May 2010 to March 2016...
December 8, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29203002/complete-tendon-achilles-rupture-following-injection-of-aethoxysklerol-polidocanol-for-the-treatment-of-chronic-achilles-tendinopathy
#15
Christopher Fenelon, John G Galbraith, Paul Hession, Lester G D'Souza
Achilles tendinopathy can be a chronic disabling condition affecting both athletic and sedentary patients. Multiple new treatment approaches have developed, including shock wave therapy and various types of injection. One of the novel treatment methods used is the injection of Aethoxysklerol or polidocanol, a sclerosing substance injected under ultrasound guidance targeting areas of neovascularisation. We report the case of a 78-year-old lady who suffered a complete Achilles tendon rupture following injection of Aethoxysklerol...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29179571/role-of-basal-cells-in-producing-persistent-lentivirus-mediated-airway-gene-expression
#16
Nigel Farrow, Martin Donnelley, Patricia Cmielewski, Eugene Roscioli, Nathan Rout-Pitt, Chantelle McIntyre, Ivan Bertoncello, David W Parsons
Cystic fibrosis (CF) lung disease is an ideal candidate for a genetic therapy. It has been shown previously that preconditioning with lysophosphatidylcholine (LPC) prior to lentiviral (LV) vector delivery results in long-term in vivo gene expression in the airway epithelium of CF mice. It was hypothesized that this outcome is largely due to transduction of airway basal cells that in turn pass the transgene onto their progeny. The aim of these studies was to confirm if the in vivo delivery of a human immunodeficiency virus type 1 (HIV-1) vesicular stomatitis virus envelope glycoprotein (VSV-G) pseudotyped LV vector following LPC airway conditioning results in transduction of mouse airway basal cells in situ and if the transgene is passed onto their progeny...
January 3, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29177197/foam-sclerotherapy-during-shunt-surgery-for-portal-hypertension-and-varices
#17
Zhe Zhang, Xueming Chen, Chenyu Li, Hai Feng, Hongzhi Yu, Renming Zhu, Tianyou Wang
Objective: This preliminary study investigated the clinical safety and efficacy of foam sclerotherapy during shunt surgery to treat portal hypertension and gastroesophageal varices. Methods: Seven patients with confirmed portal hypertension and a variceal bleeding history underwent mesocaval shunt with simultaneous polidocanol foam injection into the varices. Computed tomography and endoscopic reviews were conducted within two weeks following the procedures and around six months later...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29153963/shear-wave-elastography-swe-for-monitoring-of-treatment-of-tendinopathies-a-double-blinded-longitudinal-clinical-study
#18
Timm Dirrichs, Valentin Quack, Matthias Gatz, Markus Tingart, Björn Rath, Marcel Betsch, Christiane K Kuhl, Simone Schrading
RATIONALE AND OBJECTIVES: We aimed to investigate the diagnostic accuracy with which shear wave elastography (SWE) can be used to monitor response to treatment of tendinopathies, and to compare it to conventional ultrasound (US)-imaging methods (B-mode US (B-US) and power Doppler US (PD-US)). MATERIALS AND METHODS: A prospective Institutional Review Board-approved longitudinal study on 35 patients with 47 symptomatic tendons (17 Achilles-, 15 patellar-, and 15 humeral-epicondylar) who underwent standardized multimodal US and standardized clinical assessment before and after 6 months of treatment (tailored stretching exercise, sport break, and local Polidocanol) was carried out...
March 2018: Academic Radiology
https://www.readbyqxmd.com/read/29124942/quality-of-life-after-endovascular-sclerotherapy-of-low-flow-venous-malformations-the-efficacy-of-polidocanol-compared-with-ethanol
#19
Annamaria Weitz-Tuoretmaa, Leo Keski-Nisula, Riitta Rautio, Jussi Laranne
Background Limited information is available on mid-term results and quality of life (QOL) after endovascular sclerotherapy of venous malformations. Purpose To compare two agents-polidocanol and ethanol-with a focus on the influence on QOL after sclerotherapy. Material and Methods Forty-one consecutive patients with a venous malformation in the head and neck area or in the extremities were treated with polidocanol between 2008 and 2013. Pre- and post-treatment magnetic resonance imaging (MRI) scans were compared...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29082587/effectiveness-and-safety-of-polidocanol-for-the-treatment-of-hemangiomas-and-vascular-malformations-a-meta-analysis
#20
REVIEW
Zhi Gao, Yi Zhang, Wei Li, Chen Shi
A meta-analysis was conducted to investigate the efficacy and safety of polidocanol versus other conventional therapies in treating hemangiomas (HMs) and vascular malformations (VMs). Literature search was conducted in the Cochrane, Embase, PubMed, Web of Science, CNKI, CBM, VIP, and WanFang databases until March 5, 2017. A meta-analysis was conducted using Revman 5.3 software. A total of 19 randomized controlled trials (RCTs) involving 1,514 participants met the inclusion criteria. Regarding the effectiveness, statistically significant differences were observed between polidocanol and all the independent treatments (p = ...
January 2018: Dermatologic Therapy
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