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https://www.readbyqxmd.com/read/29113064/inhibition-of-cyclic-adenosine-monophosphate-specific-phosphodiesterase-by-various-food-plant-derived-phytotherapeutic-agents
#1
Teresa Röhrig, Olga Pacjuk, Silvia Hernández-Huguet, Johanna Körner, Katharina Scherer, Elke Richling
Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. Methods: Four plant extracts (Arbutus unedo, Camellia sinensis, Cynara scolymus, Zingiber officinale) with promising ingredient profiles and physiological effects were tested for their ability to inhibit cAMP-specific PDE in vitro in a radioactive assay...
November 4, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29055172/evaluation-of-the-antioxidant-impact-of-ginger-based-kombucha-on-the-murine-breast-cancer-model
#2
Samaneh Salafzoon, Hamideh Mahmoodzadeh Hosseini, Raheleh Halabian
Background Abnormal metabolism is a common event in cancerous cells. For example, the increase of reactive oxygen species (ROS) production, particularly due to aerobic respiration during invasive stage, results in cancer progression. Herein, the impact of kombucha tea prepared from ginger on the alteration of antioxidant agents was assessed in the breast cancer animal model. Methods Two types of kombucha tea with or without ginger were administered to BALB/c mice before and after tumor challenge. Superoxide dismutase (SOD), catalase, glutathione (GSH) and malondialdehyde (MDA) were evaluated in tumor, liver and kidney...
October 21, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29027276/natural-medicines-for-acute-renal-failure-a-review
#3
REVIEW
Motahareh Boozari, Hossein Hosseinzadeh
Acute renal failure (ARF) is a life-threating disease with high mortality percentage. Two important mechanisms of ARF are inflammation and oxidative stress. Plants are rich source of antioxidant compounds and have a strong anti-inflammatory activity, so they may be useful for the treatment of ARF. Some herbal medicines are effective against different models of experimentally induced ARF such as cisplatin, gentamicin, glycerol, and ischemia-reperfusion injury. Some of these plants such as ginseng, black seed, ginger, garlic, grape, pomegranate, saffron, and green tea are so famous and are effective against various models of ARF...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28990942/-herbal-supplement-usage-in-cardiac-patients
#4
Neslihan Pınar, Meyli Topaloğlu, Cahit Özer, Harun Alp
OBJECTIVE: Complementary and alternative medicine (CAM) has become more and more widespread around the world. CAM is a broad term that refers to all medical healthcare services, methods, and practices that are not part of standard medical care, as well as the accompanying theories and beliefs. The aim of the present study was to investigate the use of herbal medicinal products in cardiac patients, as well as the methods of administration of the products. METHODS: This descriptive cross-sectional study included 199 patients aged over 18 years who were hospitalized in the Defne Hospital department of cardiology and volunteered to participate in a 20-item survey between April 2016 and June 2016...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28866888/additive-capacity-of-6-shogaol-and-epicatechin-to-trap-methylglyoxal
#5
Qiju Huang, Pei Wang, Yingdong Zhu, Lishuang Lv, Shengmin Sang
Methylglyoxal (MGO), a reactive dicarbonyl species, is thought to contribute to the development of long-term pathological diabetes as a direct toxin or as an active precursor of advanced glycation end products (AGEs). Trapping MGO by dietary phenols to inhibit the MGO induced AGE formation is an approach for alleviating diabetic complications. The present study investigated whether dietary compounds with different structures and active sites have the additive capacity to trap MGO. Ginger phenolic constituent [6]-shogaol and tea flavonoid (-)-epicatechin were selected and tested under simulated physiological conditions, showing that they additively trapped about 41% MGO at a concentration of 10 μM within 24 h...
September 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28595182/the-effect-of-dietary-supplements-containing-green-tea-capsaicin-and-ginger-extracts-on-weight-loss-and-metabolic-profiles-in-overweight-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#6
Mohsen Taghizadeh, Narjes Farzin, Sara Taheri, Mahnaz Mahlouji, Hossein Akbari, Fatemeh Karamali, Zatollah Asemi
BACKGROUND: This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women. METHODS: This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28512603/bactericidal-activity-of-herbal-volatile-oil-extracts-against-multidrug-resistant-acinetobacter-baumannii
#7
Amornrat Intorasoot, Piyaorn Chornchoem, Siriwoot Sookkhee, Sorasak Intorasoot
AIM: The aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (Alpinia galanga Linn.), ginger (Zingiber officinale), plai (Zingiber cassumunar Roxb.), lime (Citrus aurantifolia), kaffir lime (Citrus hystrix DC.), sweet basil (Ocimum basilicum Linn.), tree basil (Ocimum gratissimum), lemongrass (Cymbopogon citratus DC.), clove (Syzygium aromaticum), and cinnamon (Cinnamomum verum) against four standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and 30 clinical isolates of multidrug-resistant A...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28472987/use-of-complementary-and-alternative-medicine-by-patients-with-end-stage-renal-disease-on-haemodialysis-in-trinidad-a-descriptive-study
#8
Mandreker Bahall
BACKGROUND: Despite the paucity of scientific evidence, complementary and alternative medicine (CAM) is widely used for the prevention and treatment of illness, holistic care, and counteracting the adverse effects of conventional medicine (CM). This study investigates the use of CAM by patients with end-stage renal disease (ESRD) on haemodialysis. METHODS: This quantitative study was conducted from November 1, 2014 to December 31, 2014 in the haemodialysis unit at San Fernando General Hospital (San Fernando, Trinidad)...
May 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28395816/regeneration-of-tert-butylhydroquinone-by-tea-polyphenols
#9
Yafang Guo, Yahui Guo, Yunfei Xie, Yuliang Cheng, He Qian, Weirong Yao
To study the antioxidant capacity (AC) regeneration of tert-butylhydroquinone (TBHQ) by tea polyphenols (TPs), a separable system has been designed for its evaluation. The AC values of three natural food matrices (liquorice, oat, and ginger) and TBHQ regenerated by TPs were all higher than their controls, and similar to the initial values (p<0.05). The average regeneration efficiency (RE) value was 1.49 for these three natural food matrices, and 0.82 for TBHQ. Electron paramagnetic resonance spectroscopy analysis has revealed the synergistic effect of TBHQ and TPs, which arose from the regeneration of TBHQ by TPs...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28258675/cancer-chemoprevention-selected-molecular-mechanisms
#10
REVIEW
Katarzyna Walczak, Sebastian Marciniak, Grażyna Rajtar
The effect of diet on cancer formation and prevention of carcinogenesis has attracted considerable attention for years and is the subject of several studies. Some components of the daily diet, such as resveratrol, curcumin, genistein, gingerol, can significantly reduce the risk of cancer or affect the rate of tumor progression. Cancer chemoprevention assumes the use of natural or synthetic biologically active substances in order to prevent, inhibit or reverse the progression of cancer. There are many biologically active compounds in several natural products, i...
March 2, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28209019/efficacy-of-specific-plant-products-on-microorganisms-causing-dental-caries
#11
M Rajini Kanth, A Ravi Prakash, G Sreenath, Vikram Simha Reddy, S Huldah
INTRODUCTION: Dental caries and periodontal diseases are the most common oral diseases seen globally, both in developed and developing countries. Oral microorganisms that is gram positive and gram negative bacteria are known to be involved in causation of these diseases. Nowadays commercially available dentrifices and mouth rinses are known to contain ingredients that can alter the oral microbial flora and have undesirable side effects such as vomiting, diarrhoea, disarrangement of oral, intestinal flora and tooth staining...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#12
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27729839/identification-of-suitable-natural-inhibitor-against-influenza-a-h1n1-neuraminidase-protein-by-molecular-docking
#13
Maheswata Sahoo, Lingaraja Jena, Surya Narayan Rath, Satish Kumar
The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27700987/a-novel-method-for-the-quantitation-of-gingerol-glucuronides-in-human-plasma-or-urine-based-on-stable-isotope-dilution-assays
#14
Carola Schoenknecht, Gaby Andersen, Peter Schieberle
The bio-active compounds of ginger (Zingiber officinale Roscoe), the gingerols, are gaining considerable attention due to their numerous beneficial health effects. In order to elucidate the physiological relevance of the ascribed effects their bioavailability has to be determined taking their metabolization into account. To quantitate in vivo generated [6]-, [8]- and [10]-gingerol glucuronides in human plasma and urine after ginger tea consumption, a simultaneous and direct liquid chromatography-tandem mass spectrometry method based on stable isotope dilution assays was established and validated...
November 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27193820/high-antiviral-effects-of-hibiscus-tea-extract-on-the-h5-subtypes-of-low-and-highly-pathogenic-avian-influenza-viruses
#15
Tugsbaatar Baatartsogt, Vuong N Bui, Dai Q Trinh, Emi Yamaguchi, Dulyatad Gronsang, Rapeewan Thampaisarn, Haruko Ogawa, Kunitoshi Imai
Viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. However, drug-resistant influenza A virus variants, including H5N1 highly pathogenic avian influenza viruses (HPAIVs), have been reported. Therefore, the discovery of novel and effective antiviral agents is warranted. We screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, lavender tea, rose tea and oak tea) against the H5N1 HPAIV in vitro...
October 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26949700/commonly-used-dietary-supplements-on-coagulation-function-during-surgery
#16
Chong-Zhi Wang, Jonathan Moss, Chun-Su Yuan
BACKGROUND: Patients who undergo surgery appear to use dietary supplements significantly more frequently than the general population. Because they contain pharmacologically active compounds, dietary supplements may affect coagulation and platelet function during the perioperative period through direct effects, pharmacodynamic interactions, and pharmacokinetic interactions. However, in this regard, limited studies have been conducted that address the pharmacological interactions of dietary supplements...
September 2015: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/26939769/quantitation-of-gingerols-in-human-plasma-by-newly-developed-stable-isotope-dilution-assays-and-assessment-of-their-immunomodulatory-potential
#17
Carola Schoenknecht, Gaby Andersen, Ines Schmidts, Peter Schieberle
In a pilot study with two volunteers, the main pungent and bioactive ginger (Zingiber officinale Roscoe) compounds, the gingerols, were quantitated in human plasma after ginger tea consumption using a newly established HPLC-MS/MS(ESI) method on the basis of stable isotope dilution assays. Limits of quantitation for [6]-, [8]-, and [10]-gingerols were determined as 7.6, 3.1, and 4.0 nmol/L, respectively. The highest plasma concentrations of [6]-, [8]-, and [10]-gingerols (42.0, 5.3, and 4.8 nmol/L, respectively) were reached 30-60 min after ginger tea intake...
March 23, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/26926182/bioactive-compounds-isolated-from-apple-tea-and-ginger-protect-against-dicarbonyl-induced-stress-in-cultured-human-retinal-epithelial-cells
#18
Chethan Sampath, Yingdong Zhu, Shengmin Sang, Mohamed Ahmedna
BACKGROUND: Methylglyoxal (MGO) is known to be a major precursor of advanced glycation end products (AGEs) which are linked to diabetes and its related complications. Naturally occurring bioactive compounds could play an important role in countering AGEs thereby minimizing the risk associated with their formation. METHODS: In this study, eight specific bioactive compounds isolated from apple, tea and ginger were evaluated for their AGEs scavenging activity using Human Retinal Pigment Epithelial (H-RPE) cells treated with MGO...
February 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26904604/survivability-of-vibrio-cholerae-o1-in-cooked-rice-coffee-and-tea
#19
John Yew Huat Tang, Bariah Ibrahim Izenty, Ahmad Juanda Nur' Izzati, Siti Rahmah Masran, Chew Chieng Yeo, Arshad Roslan, Che Abdullah Abu Bakar
This study aimed to investigate the survival of Vibrio cholerae O1 in 3 types of preparation for cooked rice, Oryza sativa L., (plain rice, rice with coconut milk, and rice with ginger); coffee, Coffea canephora, (plain coffee, coffee with sugar, and coffee with sweetened condensed milk); and tea, Camellia sinensis, (plain tea, tea with sugar, and tea with sweetened condensed milk) held at room temperature (27°C). The survival of V. cholerae O1 was determined by spread plate method on TCBS agar. Initial cultures of 8...
2013: International journal of food science
https://www.readbyqxmd.com/read/26758574/effect-of-cinnamon-cardamom-saffron-and-ginger-consumption-on-blood-pressure-and-a-marker-of-endothelial-function-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Paria Azimi, Reza Ghiasvand, Awat Feizi, Javad Hosseinzadeh, Maryam Bahreynian, Mitra Hariri, Hossein Khosravi-Boroujeni
Herbal medicines with high amounts of phytochemicals have been shown to have beneficial effects on blood pressure (BP), endothelial function and anthropometric measures. This study aimed to determine the effect of herbal treatment on BP, endothelial function and anthropometric measures in patients with type 2 diabetes mellitus (T2DM). This clinical trial included 204 T2DM patients randomly assigned to four intervention groups receiving 3 g cinnamon, 3 g cardamom, 1 g saffron or 3 g ginger with three glasses of black tea, and one control group consuming only three glasses of tea without any herbals, for 8 weeks...
June 2016: Blood Pressure
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