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https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#1
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27729839/identification-of-suitable-natural-inhibitor-against-influenza-a-h1n1-neuraminidase-protein-by-molecular-docking
#2
Maheswata Sahoo, Lingaraja Jena, Surya Narayan Rath, Satish Kumar
The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27700987/a-novel-method-for-the-quantitation-of-gingerol-glucuronides-in-human-plasma-or-urine-based-on-stable-isotope-dilution-assays
#3
Carola Schoenknecht, Gaby Andersen, Peter Schieberle
The bio-active compounds of ginger (Zingiber officinale Roscoe), the gingerols, are gaining considerable attention due to their numerous beneficial health effects. In order to elucidate the physiological relevance of the ascribed effects their bioavailability has to be determined taking their metabolization into account. To quantitate in vivo generated [6]-, [8]- and [10]-gingerol glucuronides in human plasma and urine after ginger tea consumption, a simultaneous and direct liquid chromatography-tandem mass spectrometry method based on stable isotope dilution assays was established and validated...
September 26, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27193820/high-antiviral-effects-of-hibiscus-tea-extract-on-the-h5-subtypes-of-low-and-highly-pathogenic-avian-influenza-viruses
#4
Tugsbaatar Baatartsogt, Vuong N Bui, Dai Q Trinh, Emi Yamaguchi, Dulyatad Gronsang, Rapeewan Thampaisarn, Haruko Ogawa, Kunitoshi Imai
Viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. However, drug-resistant influenza A virus variants, including H5N1 highly pathogenic avian influenza viruses (HPAIVs), have been reported. Therefore, the discovery of novel and effective antiviral agents is warranted. We screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, lavender tea, rose tea and oak tea) against the H5N1 HPAIV in vitro...
May 19, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26949700/commonly-used-dietary-supplements-on-coagulation-function-during-surgery
#5
Chong-Zhi Wang, Jonathan Moss, Chun-Su Yuan
BACKGROUND: Patients who undergo surgery appear to use dietary supplements significantly more frequently than the general population. Because they contain pharmacologically active compounds, dietary supplements may affect coagulation and platelet function during the perioperative period through direct effects, pharmacodynamic interactions, and pharmacokinetic interactions. However, in this regard, limited studies have been conducted that address the pharmacological interactions of dietary supplements...
September 2015: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/26939769/quantitation-of-gingerols-in-human-plasma-by-newly-developed-stable-isotope-dilution-assays-and-assessment-of-their-immunomodulatory-potential
#6
Carola Schoenknecht, Gaby Andersen, Ines Schmidts, Peter Schieberle
In a pilot study with two volunteers, the main pungent and bioactive ginger (Zingiber officinale Roscoe) compounds, the gingerols, were quantitated in human plasma after ginger tea consumption using a newly established HPLC-MS/MS(ESI) method on the basis of stable isotope dilution assays. Limits of quantitation for [6]-, [8]-, and [10]-gingerols were determined as 7.6, 3.1, and 4.0 nmol/L, respectively. The highest plasma concentrations of [6]-, [8]-, and [10]-gingerols (42.0, 5.3, and 4.8 nmol/L, respectively) were reached 30-60 min after ginger tea intake...
March 23, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/26926182/bioactive-compounds-isolated-from-apple-tea-and-ginger-protect-against-dicarbonyl-induced-stress-in-cultured-human-retinal-epithelial-cells
#7
Chethan Sampath, Yingdong Zhu, Shengmin Sang, Mohamed Ahmedna
BACKGROUND: Methylglyoxal (MGO) is known to be a major precursor of advanced glycation end products (AGEs) which are linked to diabetes and its related complications. Naturally occurring bioactive compounds could play an important role in countering AGEs thereby minimizing the risk associated with their formation. METHODS: In this study, eight specific bioactive compounds isolated from apple, tea and ginger were evaluated for their AGEs scavenging activity using Human Retinal Pigment Epithelial (H-RPE) cells treated with MGO...
February 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26904604/survivability-of-vibrio-cholerae-o1-in-cooked-rice-coffee-and-tea
#8
John Yew Huat Tang, Bariah Ibrahim Izenty, Ahmad Juanda Nur' Izzati, Siti Rahmah Masran, Chew Chieng Yeo, Arshad Roslan, Che Abdullah Abu Bakar
This study aimed to investigate the survival of Vibrio cholerae O1 in 3 types of preparation for cooked rice, Oryza sativa L., (plain rice, rice with coconut milk, and rice with ginger); coffee, Coffea canephora, (plain coffee, coffee with sugar, and coffee with sweetened condensed milk); and tea, Camellia sinensis, (plain tea, tea with sugar, and tea with sweetened condensed milk) held at room temperature (27°C). The survival of V. cholerae O1 was determined by spread plate method on TCBS agar. Initial cultures of 8...
2013: International journal of food science
https://www.readbyqxmd.com/read/26758574/effect-of-cinnamon-cardamom-saffron-and-ginger-consumption-on-blood-pressure-and-a-marker-of-endothelial-function-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-clinical-trial
#9
Paria Azimi, Reza Ghiasvand, Awat Feizi, Javad Hosseinzadeh, Maryam Bahreynian, Mitra Hariri, Hossein Khosravi-Boroujeni
Herbal medicines with high amounts of phytochemicals have been shown to have beneficial effects on blood pressure (BP), endothelial function and anthropometric measures. This study aimed to determine the effect of herbal treatment on BP, endothelial function and anthropometric measures in patients with type 2 diabetes mellitus (T2DM). This clinical trial included 204 T2DM patients randomly assigned to four intervention groups receiving 3 g cinnamon, 3 g cardamom, 1 g saffron or 3 g ginger with three glasses of black tea, and one control group consuming only three glasses of tea without any herbals, for 8 weeks...
June 2016: Blood Pressure
https://www.readbyqxmd.com/read/26749808/combination-of-antioxidants-from-different-sources-could-offer-synergistic-benefits-a-case-study-of-tea-and-ginger-blend
#10
Solomon A Makanjuola, Victor N Enujiugha, Olufunmilayo S Omoba, David M Sanni
Tea and ginger are plants with high antioxidant potential. Combinations of antioxidants from different sources could also produce synergistic antioxidant effects. This study investigated the influence of solvent on antioxidant content of tea, ginger, and tea + ginger blends. Under the investigated extraction conditions, water was the most effective extraction solvent to maximise peroxide scavenging and iron chelating activity of tea, ginger, and their blends. Aqueous ethanol was the most effective solvent to maximise ABTS radical scavenging activity and ethanol was the best solvent to maximise DPPH radical scavenging activity...
November 2015: Natural Product Communications
https://www.readbyqxmd.com/read/26642658/hematological-and-immunobiochemical-study-of-green-tea-and-ginger-extracts-in-experimentally-induced-diabetic-rabbits
#11
Ahmed Elkirdasy, Saad Shousha, Abdulmohsen H Alrohaimi, M Faiz Arshad
The present study was designed to investigate the effects of the extract of green tea and/or ginger on some hematological and immunobiochemical profiles in alloxan-induced diabetic rabbits. The results revealed that treatment of diabetic animals with extract of green tea and/or ginger elevated the decreased HDL-c and LDL-c but significantly decreased triglycerides, the elevated glucose and GOT concentrations. The result also displayed a non-significant increase in the levels of CRP and fibrinogen. The experiment also revealed that the elevated MDA and GSH level fell down to the normal control group...
May 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26471236/phase-ib-randomized-double-blinded-placebo-controlled-dose-escalation-study-of-polyphenon-e-in-patients-with-barrett-s-esophagus
#12
RANDOMIZED CONTROLLED TRIAL
Andrew K Joe, Felice Schnoll-Sussman, Robert S Bresalier, Julian A Abrams, Hanina Hibshoosh, Ken Cheung, Richard A Friedman, Chung S Yang, Ginger L Milne, Diane D Liu, J Jack Lee, Kazeem Abdul, Michelle Bigg, Jessica Foreman, Tao Su, Xiaomei Wang, Aqeel Ahmed, Alfred I Neugut, Esther Akpa, Scott M Lippman, Marjorie Perloff, Powel H Brown, Charles J Lightdale
This study was conducted to determine the safety and efficacy of the green tea-derived Polyphenon E (Poly E) in patients with Barrett's Esophagus (BE). Subjects were randomized to a 6-month, twice daily (BID) oral treatment of placebo or Poly E (200, 400, or 600 mg). Endoscopic evaluation, including biopsies, was performed before and after treatment. The primary objective was to demonstrate safety; secondary objectives investigated catechin accumulation and effects in clinical specimens. Of the 44 enrolled subjects, 11 received placebo, and 33 received Poly E...
December 2015: Cancer Prevention Research
https://www.readbyqxmd.com/read/26405530/optimization-and-prediction-of-antioxidant-properties-of-a-tea-ginger-extract
#13
Solomon Akinremi Makanjuola, Victor Ndigwe Enujiugha, Olufunmilayo Sade Omoba, David Morakinyo Sanni
A response surface approach was used to investigate the effects of temperature, concentration, and time on the antioxidant properties (total flavonoid (TF), total phenol (TP), peroxide scavenging activity (PS), iron chelating activity (IC), DPPH radical-scavenging ability (DPPH), ABTS assay (ABTS)) of aqueous extract of tea-ginger (2:1) powder. Color indices, pH, and redox potential of the tea-ginger powder were also measured and used as independent variables for the prediction of antioxidant properties of the extract using ordinary least square (OLSR), principal component (PCR), and partial least square (PLSR) regression...
September 2015: Food Science & Nutrition
https://www.readbyqxmd.com/read/26401401/use-of-household-ingredients-as-complementary-medicines-for-perceived-hypoglycemic-benefit-among-sri-lankan-diabetic-patients-a-cross-sectional-survey
#14
Arjuna Bandara Medagama, Danusha Senadhira
BACKGROUND: Biologic based therapies are frequently used as complementary medicines in diabetes. The aim of this study was to identify the commonly used herbal remedies and their preparations in Sri Lankan patients with Type 2 diabetes. METHODS: This is a descriptive, cross-sectional study on 220 diabetic patients using herbal remedies for perceived glycemic benefit. RESULTS: All the patients used their regular conventional medications together with herbal remedies...
April 2015: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/26366255/herbal-medicines-use-during-pregnancy-a-review-from-the-middle-east
#15
REVIEW
Lisha J John, Nisha Shantakumari
The prevalence of the herbal medicines use is on the rise across the world, especially amongst pregnant women. The scenario in the Middle Eastern region was reviewed to explore the prevalence, usage pattern, motivation, and attitude towards use of herbal medicine by pregnant women. Literature published up to December 2012 showed the prevalence of herbal medicine use varied between 22.3-82.3%, implying a rising trend in the utilization of herbal medicine during pregnancy. The most common herbs used were peppermint, ginger, thyme, chamomile, sage, aniseed, fenugreek, and green tea...
July 2015: Oman Medical Journal
https://www.readbyqxmd.com/read/26177486/effects-of-cinnamon-cardamom-saffron-and-ginger-consumption-on-markers-of-glycemic-control-lipid-profile-oxidative-stress-and-inflammation-in-type-2-diabetes-patients
#16
Paria Azimi, Reza Ghiasvand, Awat Feizi, Mitra Hariri, Behnoud Abbasi
OBJECTIVES: Type 2 diabetes (T2D) may be caused by elevated oxidative stress, inflammation, and hyperglycemia. The phytochemicals in several herbal medicines are reported to effectively improve diabetes and to ameliorate diabetic complications. The aim of the present study was to determine the effects of cinnamon, cardamom, saffron, and ginger as supplementary remedies in T2D. METHODS: This randomized controlled, clinical trial included 204 T2D patients. The participants were randomly assigned to four intervention groups receiving 3 glasses of black tea and either 3 g cardamom, or cinnamon, or ginger, or 1 g saffron and one control group which consumed only 3 tea glasses without any herbal medicine for 8 weeks...
October 2014: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/26092628/brain-food-for-alzheimer-free-ageing-focus-on-herbal-medicines
#17
REVIEW
Helmut M Hügel
Healthy brain aging and the problems of dementia and Alzheimer's disease (AD) are a global concern. Beyond 60 years of age, most, if not everyone, will experience a decline in cognitive skills, memory capacity and changes in brain structure. Longevity eventually leads to an accumulation of amyloid plaques and/or tau tangles, including some vascular dementia damage. Therefore, lifestyle choices are paramount to leading either a brain-derived or a brain-deprived life. The focus of this review is to critically examine the evidence, impact, influence and mechanisms of natural products as chemopreventive agents which induce therapeutic outcomes that modulate the aggregation process of beta-amyloid (Aβ), providing measureable cognitive benefits in the aging process...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/25861496/maintenance-therapy-containing-metformin-and-or-zyflamend-for-advanced-prostate-cancer-a-case-series
#18
Mehmet Asim Bilen, Sue-Hwa Lin, Dean G Tang, Kinjal Parikh, Mong-Hong Lee, Sai-Ching J Yeung, Shi-Ming Tu
Metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. Zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, Chinese goldthread, hu zhang, barberry, and basil skullcap. We propose a maintenance regimen with metformin and/or Zyflamend that targets cancer stem cells and the tumor microenvironment to keep the cancer dormant and prevent it from activation from dormancy...
2015: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/25845895/caffeine-awareness-in-children-insights-from-a-pilot-study
#19
Tushar P Thakre, Ketan Deoras, Catherine Griffin, Aarthi Vemana, Petra Podmore, Jyoti Krishna
STUDY OBJECTIVES: Caffeine, a commonly consumed psychoactive substance, can have significant effects on sleep. Caffeine intake among children is increasing, mainly in the form of sodas. However, adolescent caffeine consumers may lack knowledge about the caffeine content in common beverages. If true, this very fact may hamper the assessment of the effects of caffeine consumption on sleep in children if such assessments are a priori dependent on responders being able to reliably distinguish between caffeinated and noncaffeinated beverages...
July 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/25840923/foods-provoking-and-alleviating-symptoms-in-gastroparesis-patient-experiences
#20
Victoria Wytiaz, Carol Homko, Frank Duffy, Ron Schey, Henry P Parkman
BACKGROUND: Nutritional counseling for gastroparesis focuses on reduction of meal size, fiber, and fat to control symptoms. The tolerance of gastroparesis patients for particular foods is largely anecdotal. The aim of this study was to identify and characterize foods provoking or alleviating gastroparesis symptoms. METHODS: Gastroparesis patients completed: (1) Demographic Questionnaire; (2) Patient Assessment of Upper GI Symptoms; (3) Food Toleration and Aversion survey asking patients about experiences when eating certain foods utilizing a scale from -3 (greatly worsening symptoms) to +3 (greatly improving symptoms)...
April 2015: Digestive Diseases and Sciences
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