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easl guidelines for acute liver failure

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https://www.readbyqxmd.com/read/27277335/acute-on-chronic-liver-failure-in-cirrhosis
#1
Vicente Arroyo, Richard Moreau, Patrick S Kamath, Rajiv Jalan, Pere Ginès, Frederik Nevens, Javier Fernández, Uyen To, Guadalupe García-Tsao, Bernd Schnabl
The definition of acute-on-chronic liver failure (ACLF) remains contested. In Europe and North America, the term is generally applied according to the European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) Consortium guidelines, which defines this condition as a syndrome that develops in patients with cirrhosis and is characterized by acute decompensation, organ failure and high short-term mortality. One-third of patients who are hospitalized for acute decompensation present with ACLF at admission or develop the syndrome during hospitalization...
2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/26807378/acute-hepatic-phenotype-of-wilson-disease-clinical-features-of-acute-episodes-and-chronic-lesions-remaining-in-survivors
#2
Hisao Hayashi, Yasuaki Tatsumi, Shinsuke Yahata, Hiroki Hayashi, Kenji Momose, Ryohei Isaji, Youji Sasaki, Kazuhiko Hayashi, Shinya Wakusawa, Hidemi Goto
BACKGROUND AND AIMS: Wilson disease (WD) is an inherited disorder of copper metabolism, and an international group for the study of WD (IGSW) has proposed three phenotypes for its initial presentation: acute hepatic, chronic hepatic, and neurologic phenotypes. Characterization of the acute hepatic phenotype may improve our understanding of the disease. METHODS: Clinical features of 10 WD patients with the acute hepatic phenotype and characteristics of chronic lesions remaining in survivors were assessed by the European Association for the Study of the Liver (EASL) guidelines...
December 28, 2015: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/24840673/single-centre-validation-of-the-easl-clif-consortium-definition-of-acute-on-chronic-liver-failure-and-clif-sofa-for-prediction-of-mortality-in-cirrhosis
#3
Pedro E Soares E Silva, Leonardo Fayad, César Lazzarotto, Marcelo F Ronsoni, Maria L Bazzo, Bruno S Colombo, Esther B Dantas-Correa, Janaína L Narciso-Schiavon, Leonardo L Schiavon
BACKGROUND & AIMS: The idea of acute-on-chronic liver failure (ACLF) has emerged to identify those subjects with organ failure and high mortality rates. However, the absence of a precise definition has limited the clinical application and research related to the ACLF concept. We sought to validate the ACLF definition and the CLIF-SOFA Score recently proposed by the EASL-CLIF Consortium in a cohort of patients admitted for acute decompensation (AD) of cirrhosis. METHODS: In this prospective cohort study, patients were followed during their hospital stay and thirty and 90-day mortality was evaluated by phone call, in case of hospital discharge...
May 2015: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/24530646/bacterial-infections-in-cirrhosis-a-position-statement-based-on-the-easl-special-conference-2013
#4
Rajiv Jalan, Javier Fernandez, Reiner Wiest, Bernd Schnabl, Richard Moreau, Paolo Angeli, Vanessa Stadlbauer, Thierry Gustot, Mauro Bernardi, Rafael Canton, Agustin Albillos, Frank Lammert, Alexander Wilmer, Rajeshwar Mookerjee, Jordi Vila, Rita Garcia-Martinez, Julia Wendon, José Such, Juan Cordoba, Arun Sanyal, Guadalupe Garcia-Tsao, Vicente Arroyo, Andrew Burroughs, Pere Ginès
Bacterial infections are very common and represent one of the most important reasons of progression of liver failure, development of liver-related complications, and mortality in patients with cirrhosis. In fact, bacterial infections may be a triggering factor for the occurrence of gastrointestinal bleeding, hypervolemic hyponatremia, hepatic encephalopathy, kidney failure, and development of acute-on-chronic liver failure. Moreover, infections are a very common cause of repeated hospitalizations, impaired health-related quality of life, and increased healthcare costs in cirrhosis...
June 2014: Journal of Hepatology
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