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https://www.readbyqxmd.com/read/28528264/baseline-and-longitudinal-variability-of-normal-tissue-uptake-values-of-18-f-fluorothymidine-pet-images
#1
Matthijs C F Cysouw, Gerbrand M Kramer, Virginie Frings, Adrianus J De Langen, Mariëlle J Wondergem, Laura M Kenny, Eric O Aboagye, Carsten Kobe, Jürgen Wolf, Otto S Hoekstra, Ronald Boellaard
PURPOSE: [(18)F]-fluorothymidine ([(18)F]-FLT) is a PET-tracer enabling in-vivo visualization and quantification of tumor cell proliferation. For qualitative and quantitative analysis, adequate knowledge of normal tissue uptake is indispensable. This study aimed to quantitatively investigate baseline tracer uptake of blood pool, lung, liver and bone marrow and their precision, and to assess the longitudinal effect of systemic treatment on biodistribution. METHODS: (18)F-FLT-PET(/CT) scans (dynamic or static) of 90 treatment-naïve oncological patients were retrospectively evaluated...
May 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28494189/increased-placental-sflt-1-but-unchanged-plgf-expression-in-late-onset-preeclampsia
#2
Laura Ehrlich, Alice Hoeller, Michaela Golic, Florian Herse, Frank H Perschel, Wolfgang Henrich, Ralf Dechend, Berthold Huppertz, Stefan Verlohren
OBJECTIVE: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). METHODS: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased...
May 11, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28478827/mild-anemia-during-pregnancy-upregulates-placental-vascularity-development
#3
A Stangret, M Skoda, A Wnuk, M Pyzlak, D Szukiewicz
The connection between maternal hematological status and pregnancy outcome has been shown by many independent researchers. Attention was initially focused on the adverse effects of moderate and severe anemia. Interestingly, some studies revealed that mild anemia was associated with optimal fetal development and was not affecting pregnancy outcome. The explanation for this phenomenon became a target for scientists. Hemodilution, physiologic anemia and relative decrease in hemoglobin concentration are the changes observed during pregnancy but they do not explain the reasons for the positive influence of mild anemia on a fetomaternal unit...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28475024/correlations-of-18f-fdg-and-18f-flt-uptake-on-pet-with-ki-67-expression-in-patients-with-lung-cancer-a-meta-analysis
#4
Guohua Shen, Huan Ma, Fuwen Pang, Pengwei Ren, Anren Kuang
Background Positron emission tomography (PET) imaging using the radiotracers 18F-fluorodeoxyglucose (FDG) or 18F-fluorothymidine (FLT) has been proposed as imaging biomarkers of cell proliferation. Purpose To explore the correlations of FDG and FLT uptake with the Ki-67 labeling index in patients with lung cancer. Material and Methods Major databases were systematically searched for all relevant literature published in English. The correlation coefficient (rho) and its 95% confidence interval (CI) of individual studies were meta-analyzed using a random-effects model...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28469014/untangling-the-roles-of-microclimate-behaviour-and-physiological-polymorphism-in-governing-vulnerability-of-intertidal-snails-to-heat-stress
#5
Yun-Wei Dong, Xiao-Xu Li, Francis M P Choi, Gray A Williams, George N Somero, Brian Helmuth
Biogeographic distributions are driven by cumulative effects of smaller scale processes. Thus, vulnerability of animals to thermal stress is the result of physiological sensitivities to body temperature (Tb), microclimatic conditions, and behavioural thermoregulation. To understand interactions among these variables, we analysed the thermal tolerances of three species of intertidal snails from different latitudes along the Chinese coast, and estimated potential Tb in different microhabitats at each site. We then empirically determined the temperatures at which heart rate decreased sharply with rising temperature (Arrhenius breakpoint temperature, ABT) and at which it fell to zero (flat line temperature, FLT) to calculate thermal safety margins (TSM)...
May 17, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28429366/analysis-of-transcriptional-activities-of-angiogenic-biomarkers-during-intrauterine-complications-leading-to-preterm-birth
#6
M Rabajdová, R Dudič, P Urban, V Dudičová, P Urdzík, M Mareková
OBJECTIVE: Pre-eclampsia, growth retardation and preterm delivery are the most common reasons leading to increased maternal and perinatal mortality. The increased expression of hypoxia induced factors, such as HIF-1, triggers the overexpression of anti-angiogenic genes. The aim of this study was to determine the transcriptional activity of individual pro- and anti-angiogenic markers (VEGF, HIF-1, sEng, Flt-1, PlGF-1) in maternal blood samples from patients with spontaneous preterm labor, preterm labor in combination with pre-eclampsia and fetal growth restriction in comparison with physiologically terminated pregnancies...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28412217/dalbergia-odorifera-extract-promotes-angiogenesis-through-upregulation-of-vegfrs-and-pi3k-mapk-signaling-pathways
#7
Zhu-Ming Fan, Da-Ying Wang, Jian-Mei Yang, Zhi-Xiu Lin, Ai-Lin Yang, Hua Fan, Min Cao, Su-Yun Yuan, Zong-Jun Liu, Xin Zhou, You-Hua Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The heart wood of Dalbergia odorifera is a Chinese herbal medicine commonly used for the treatment of various ischemic diseases in Chinese medicine practice. AIM OF THE STUDY: In this study, therapeutic angiogenesis effects of the Dalbergia odorifera extract (DOE) were investigated on transgenic zebrafish in vivo and human umbilical vein endothelial cells (HUVECs) in vitro. MATERIALS AND METHODS: The pro-angiogenic effects of DOE on zebrafish were examined by subintestinal vessels (SIVs) sprouting assay and intersegmental vessels (ISVs) injury assay...
April 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28395328/cystic-endometrial-hyperplasia-pyometra-syndrome-in-bitches-identification-of-hemodynamic-inflammatory-and-cell-proliferation-changes
#8
Gisele Almeida Lima Veiga, Ricardo Henrique Miziara, Daniel Souza Ramos Angrimani, Paula Carvalho Papa, Bruno Cogliati, Camila Infantosi Vannucchi
Cystic endometrial hyperplasia (CEH)-pyometra syndrome is one of the most common diseases of noncastrated female dogs. However, determination of etiological mechanisms and differential diagnosis of CEH-pyometra syndrome are undefined. The aim of this study is to compare immunohistochemically the expression of cyclooxygenase-2 (COX-2) inflammatory mediator, Ki-67 antigen proliferation marker, vascular endothelial growth factor (VEGF-A) angiogenesis mediator and its FLT-1 and KDR receptors, and correlate with Doppler velocimetry of uterine artery and endometrial vascularization in bitches with CEH-pyometra syndrome...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28387306/in-vivo-comparison-of-18-f-flt-uptake-ct-number-tumor-volume-in-evaluation-of-repopulation-during-radiotherapy-for-lung-cancer
#9
Xiaoli Zhang, Jinming Yu, Chengming Li, Xindong Sun, Xue Meng
Accelerated repopulation has been observed in various tumors. This study was aimed to evaluate the potential of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake and Computed Tomography Number (CTN) in monitoring tumor responses to radiotherapy compared with tumor volume (TV) changes. Tumor bearing nude mice were assigned to either irradiated daily or every second day group and then randomized to 6 sub-groups to receive 0Gy, 6Gy, 12Gy, 18Gy, 24Gy, 36Gy irradiation, respectively. TV was measured every 3 days...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386889/source-apportionment-of-polycyclic-aromatic-hydrocarbons-and-n-alkanes-in-the-soil-sediment-profile-of-jianghan-oil-field-china
#10
Jie Ma, Hui Liu, Lei Tong, Yan Wang, Shan Liu, Lei Zhao, Liangjun Hou
Surface soil in oil exploration area always contains high contents of polycyclic aromatic hydrocarbons (PAHs) and n-alkanes. To investigate the migration possibility of PAHs and n-alkanes from surface through aquitard and aquiclude to aquifer, the distribution, together with the source apportionment using several indicators, such as composition pattern, fluoranthene/(fluoranthene+pyrene) (Flt/(Flt+Pyr)), anthracene/(anthracene+phenanthrene) (Ant/(Ant+PA)), and the carbon preference index (CPI) of n-alkanes, in a 30-m-deep soil-sediment profile were studied...
April 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28379296/relaxin-treatment-reduces-angiotensin-ii-induced-vasoconstriction-in-pregnancy-and-protects-against-endothelial-dysfunction%C3%A2
#11
Sarah A Marshall, Chen Huei Leo, Jane E Girling, Marianne Tare, Sally Beard, Natalie J Hannan, Laura J Parry
The peptide relaxin has gained considerable attention as a new vasoactive drug, largely through its beneficial therapeutic effects in cardiovascular disease. In this study, we tested the hypothesis that relaxin treatment alleviates systemic vascular dysfunction characteristic of hypertensive diseases of pregnancy. We investigated vascular effects and mechanisms of relaxin action in (i) pregnant relaxin-deficient (Rln-/-) mice with enhanced responses to angiotensin II (AngII) and (ii) arteries pre-incubated ex vivo in trophoblast conditioned media (TCM) to induce endothelial dysfunction...
April 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28375169/an-assessment-of-early-response-to-targeted-therapy-via-molecular-imaging-a-pilot-study-of-3-deoxy-3-18-f-fluorothymidine-positron-emission-tomography-18-f-flt-pet-ct-in-prostate-adenocarcinoma
#12
Kalevi Kairemo, Gregory C Ravizzini, Homer A Macapinlac, Vivek Subbiah
Fluorothymidine is a thymidine analog labeled with fluorine-18 fluorothymidine for positron emission tomography ((18)F-FLT-PET) imaging. Thymidine is a nucleic acid that is used to build DNA. Fluorine-18 fluorothymidine ((18)F-FLT) utilizes the same metabolic pathway as does thymidine but has a very low incidence of being incorporated into the DNA (<1%). (18)F-FLT-PET could have a role in the evaluation of response to targeted therapy. We present here a pilot study where we investigated cellular metabolism and proliferation in patients with prostate cancer before and after targeted therapy...
April 4, 2017: Diagnostics
https://www.readbyqxmd.com/read/28371832/timed-sequential-therapy-of-the-selective-t-type-calcium-channel-blocker-mibefradil-and-temozolomide-in-patients-with-recurrent-high-grade-gliomas
#13
Matthias Holdhoff, Xiaobu Ye, Jeffrey G Supko, Louis B Nabors, Arati S Desai, Tobias Walbert, Glenn J Lesser, William L Read, Frank S Lieberman, Martin A Lodge, Jeffrey Leal, Joy D Fisher, Serena Desideri, Stuart A Grossman, Richard L Wahl, David Schiff
Background: Mibefradil (MIB), previously approved for treatment of hypertension, is a selective T-type calcium channel blocker with preclinical activity in high-grade gliomas (HGGs). To exploit its presumed mechanism of impacting cell cycle activity (G1 arrest), we designed a phase I study to determine safety and the maximum tolerated dose (MTD) of MIB when given sequentially with temozolomide (TMZ) in recurrent (r)HGG. Methods: Adult patients with rHGG ≥3 months from TMZ for initial therapy received MIB in 4 daily doses (q...
June 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28362701/acute-myeloid-leukemia-aml-upregulation-of-baalc-mn1-mllt11-evi1-gene-cluster-relate-with-poor-overall-survival-and-a-possible-linkage-with-coexpression-of-myc-bcl2-proteins
#14
Ariz Akhter, Fahad Farooq, Ghaleb Elyamany, Muhammad K Mughal, Fariborz Rashid-Kolvear, Meer-Taher Shabani-Rad, Lesley Street, Adnan Mansoor
BACKGROUND: Molecular heterogeneity accounts for the variable and often poor prognosis in acute myeloid leukemia (AML). The current risk stratification strategy in clinical practice is limited to karyotyping and limited molecular studies screening for genetic mutations such as FLT-3 and NPM1. There is opportunity to identify further molecular prognostic markers, which may also lay the groundwork for the development of novel targeted therapies. Complex molecular technologies require transition into widely available laboratory platforms, for better integration into routine clinical practice...
March 30, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28360204/assessing-bone-marrow-activity-in-patients-with-myelofibrosis-results-of-a-pilot-study-of-18-f-flt-pet
#15
Laetitia Vercellino, Matthieu-John Ouvrier, Emmanuelle Barré, Bruno Cassinat, Virginie De Beco, Christine Dosquet, Sylvie Chevret, Véronique Meignin, Christine Chomienne, Marie-Elisabeth Toubert, Pascal Merlet, Jean-Jacques Kiladjian
Aim: An emerging non-invasive approach to assess tissue proliferation utilizes the positron emission tomography (PET) tracer 3'-deoxy-3'[(18)F]-fluorothymidine, ((18)F-FLT). To evaluate the diagnostic values of this technique in myelofibrosis, (18)F-FLT PET imaging results were compared with bone marrow histology and bone marrow scintigraphy (BMS), the gold standard techniques in this clinical situation. Materials and Methods: Fifteen patients with histology-proven myelofibrosis (MF) were included consecutively in the study...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28357103/vegf-flt-1-and-microvessel-density-in-primary-tumors-as-predictive-factors-of-colorectal-cancer-prognosis
#16
Justyna Zygoń, Mariusz Szajewski, Wiesław Janusz Kruszewski, Robert Rzepko
Angiogenesis in the primary tumor is known to be necessary for tumor progression in adenocarcinomas of the colon. However, whether angiogenesis in the primary tumors of patients with colorectal cancer affects their prognosis has yet to be fully elucidated. The aim of the present study was to assess the association between selected pathoclinical parameters and overall survival of resectable colorectal cancer patients with the expression of angiogenesis-promoting factors, including vascular endothelial growth factor (VEGF) and Fms-like tyrosine kinase receptor (Flt-1), and microvessel density (MVD) in the primary tumor...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28351588/synthesis-and-anti-hiv-activities-of-unsymmetrical-long-chain-dicarboxylate-esters-of-dinucleoside-reverse-transcriptase-inhibitors
#17
Hitesh K Agarwal, Bhupender S Chhikara, Gustavo F Doncel, Keykavous Parang
A series of 11 unsymmetrical dicarboxylate conjugates of dinucleoside reverse transcriptase inhibitors were synthesized. Three dicarboxylic acids, succinic acid, suberic acid and 1,14-tetradecandioc acid, were diesterified with either 3'-azido-2',3'-dideoxythymidine (AZT), 3'-fluoro-2',3'-dideoxythymidine (FLT), 2',3'-dideoxy-3'-thiacytidine (3TC), or 5-fluoro-2',3'-dideoxy-3'-thiacytidine (FTC). The anti-HIV activity of synthesized compounds was evaluated against HIV-1 X4 (IIIB) and R5 (BaL) viral strains in single-round infection assays...
May 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28332869/perceived-enjoyment-concentration-intention-and-speed-violation-behavior-using-flow-theory-and-theory-of-planned-behavior
#18
Charles Atombo, Chaozhong Wu, Hui Zhang, Tina D Wemegah
OBJECTIVE: Road accidents are an important public health concern and speeding is a major contributor. Although, flow theory (FLT) is a valid model for understanding behavior, currently the nature of the roles and interplay, of FLT constructs within the theory of planned behavior (TPB) framework when attempting to explain the determinants of motivations for intention to speed and speeding behavior of car drivers is not yet known. The study aims to synthesize TPB and FLT in explaining drivers of advanced vehicles intention to speed and speed violation behavior and evaluate factors which are critical for explaining intention and behavior...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28323906/flt-1-gene-polymorphisms-and-protein-expression-profile-in-rheumatoid-arthritis
#19
Agnieszka Paradowska-Gorycka, Anna Sowinska, Andrzej Pawlik, Damian Malinowski, Barbara Stypinska, Ewa Haladyj, Katarzyna Romanowska-Prochnicka, Marzena Olesinska
OBJECTIVES: Inflammation and angiogenesis are a significant element of pathogenesis in rheumatoid arthritis (RA). The FLT-1- triggering factor for production of proinflammatory cytokines-might contributes to inflammation in patients with RA. Association of the FLT-1 polymorphisms with different "angiogenic diseases" suggests that it may be a novel genetic risk factor also for RA. The aim of the study was to identify FLT-1 genetic variants and their possible association with sFLT-1 levels, susceptibility to and severity of RA...
2017: PloS One
https://www.readbyqxmd.com/read/28322131/soluble-flt-1-has-cytotoxic-effects-on-bewo-choriocarcinoma-cells
#20
Michiko Yamashita, Keiichi Kumasawa, Tatsuya Miyake, Hitomi Nakamura, Tadashi Kimura
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis and is overexpressed in many kinds of malignant tumors. Soluble VEGF receptor 1 (sVEGFR-1/ soluble fms-like tyrosine kinase 1 [sFlt-1]) plays a role as an inhibitor of VEGF, and an antitumor effect has been shown in several studies using sFlt-1. Recently, in addition to its antiangiogenic effect, it was reported that sFlt-1 has direct cytotoxicity. MATERIALS AND METHODS: Transfection of sFlt-1 plasmid DNA was performed in the BeWo choriocarcinoma cell line...
January 1, 2017: Reproductive Sciences
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