Gaurav Malviya, Tamsin R M Lannagan, Emma Johnson, Agata Mackintosh, Robert Bielik, Adam Peters, Dmitry Soloviev, Gavin Brown, Rene Jackstadt, Colin Nixon, Kathryn Gilroy, Andrew Campbell, Owen J Sansom, David Y Lewis
PURPOSE: The current approach for molecular subtyping of colon cancer relies on gene expression profiling, which is invasive and has limited ability to reveal dynamics and spatial heterogeneity. Molecular imaging techniques, such as PET, present a noninvasive alternative for visualizing biological information from tumors. However, the factors influencing PET imaging phenotype, the suitable PET radiotracers for differentiating tumor subtypes, and the relationship between PET phenotypes and tumor genotype or gene expression-based subtyping remain unknown...
March 17, 2024: Clinical Cancer Research