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https://www.readbyqxmd.com/read/28332869/perceived-enjoyment-concentration-intention-and-speed-violation-behavior-using-flow-theory-and-theory-of-planned-behavior
#1
Charles Atombo, Chaozhong Wu, Hui Zhang, Tina D Wemegah
OBJECTIVE: Road accidents are an important public health concern and speeding is a major contributor. Although, flow theory (FLT) is a valid model for understanding behavior, currently the nature of the roles and interplay, of FLT constructs within the theory of planned behavior (TPB) framework when attempting to explain the determinants of motivations for intention to speed and speeding behavior of car drivers is not yet known. The study aims to synthesize TPB and FLT in explaining drivers of advanced vehicles intention to speed and speed violation behavior and evaluate factors which are critical for explaining intention and behavior...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28323906/flt-1-gene-polymorphisms-and-protein-expression-profile-in-rheumatoid-arthritis
#2
Agnieszka Paradowska-Gorycka, Anna Sowinska, Andrzej Pawlik, Damian Malinowski, Barbara Stypinska, Ewa Haladyj, Katarzyna Romanowska-Prochnicka, Marzena Olesinska
OBJECTIVES: Inflammation and angiogenesis are a significant element of pathogenesis in rheumatoid arthritis (RA). The FLT-1- triggering factor for production of proinflammatory cytokines-might contributes to inflammation in patients with RA. Association of the FLT-1 polymorphisms with different "angiogenic diseases" suggests that it may be a novel genetic risk factor also for RA. The aim of the study was to identify FLT-1 genetic variants and their possible association with sFLT-1 levels, susceptibility to and severity of RA...
2017: PloS One
https://www.readbyqxmd.com/read/28322131/soluble-flt-1-has-cytotoxic-effects-on-bewo-choriocarcinoma-cells
#3
Michiko Yamashita, Keiichi Kumasawa, Tatsuya Miyake, Hitomi Nakamura, Tadashi Kimura
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis and is overexpressed in many kinds of malignant tumors. Soluble VEGF receptor 1 (sVEGFR-1/ soluble fms-like tyrosine kinase 1 [sFlt-1]) plays a role as an inhibitor of VEGF, and an antitumor effect has been shown in several studies using sFlt-1. Recently, in addition to its antiangiogenic effect, it was reported that sFlt-1 has direct cytotoxicity. MATERIALS AND METHODS: Transfection of sFlt-1 plasmid DNA was performed in the BeWo choriocarcinoma cell line...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28287126/pet-cell-tracking-using-18-f-flt-is-not-limited-by-local-reuptake-of-free-radiotracer
#4
Mark G MacAskill, Adriana S Tavares, Junxi Wu, Christophe Lucatelli, Joanne C Mountford, Andrew H Baker, David E Newby, Patrick W F Hadoke
Assessing the retention of cell therapies following implantation is vital and often achieved by labelling cells with 2'-[(18)F]-fluoro-2'-deoxy-D-glucose ((18)F-FDG). However, this approach is limited by local retention of cell-effluxed radiotracer. Here, in a preclinical model of critical limb ischemia, we assessed a novel method of cell tracking using 3'-deoxy-3'-L-[(18)F]-fluorothymidine ((18)F-FLT); a clinically available radiotracer which we hypothesise will result in minimal local radiotracer reuptake and allow a more accurate estimation of cell retention...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28284101/relationship-between-14-c-meaib-uptake-and-amino-acid-transporter-family-gene-expression-levels-or-proliferative-activity-in-a-pilot-study-in-human-carcinoma-cells-comparison-with-3-h-methionine-uptake
#5
Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Emi Ogawa, Hiroyuki Okudaira, Masato Kobayashi, Mitsuyoshi Yoshimoto, Naoto Shikano, Keiichi Kawai
INTRODUCTION: To clarify the difference between system A and L amino acid transport imaging in PET clinical imaging, we focused on the use of α-[N-methyl-(11)C]-methylaminoisobutyric acid ([(11)C]MeAIB), and compared it with [S-methyl-(11)C]-L-methionine ([(11)C]MET). The aim of this study was to assess the correlation of accumulation of these two radioactive amino acid analogs with expression of amino acid transporters and cell proliferative activity in carcinoma cells. METHODS: Amino acid uptake inhibitor studies were performed in four human carcinoma cells (epidermal carcinoma A431, colorectal carcinoma LS180, and lung carcinomas PC14/GL and H441/GL) using the radioisotope analogs [(3)H]MET and [(14)C]MeAIB...
January 26, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28283219/pet-mri-multiparametric-imaging-of-brain-tumors
#6
Jiří Ferda, Eva Ferdová, Ondřej Hes, Jan Mraček, Boris Kreuzberg, Jan Baxa
A combination of morphological imaging of the brain with microstructural and functional imaging provides a comprehensive overview of the properties of individual tissues. While diffusion weighted imaging provides information about tissue cellularity, spectroscopic imaging allows us to evaluate the integrity of neurons and possible anaerobic glycolysis during tumor hypoxia, in addition to the presence of accelerated synthesis or degradation of cellular membranes; on the other hand, PET metabolic imaging is used to evaluate major metabolic pathways, determining the overall extent of the tumor ((18)F-FET, (18)F-FDOPA, (18)F-FCH) or the degree of differentiation ((18)F-FDG, (18)F-FLT, (18)F-FDOPA and (18)F-FET)...
February 22, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28259039/transfer-effects-of-step-training-on-stepping-performance-in-untrained-directions-in-older-adults-a-randomized-controlled-trial
#7
Yoshiro Okubo, Jasmine Menant, Manasa Udyavar, Matthew A Brodie, Benjamin K Barry, Stephen R Lord, Daina L Sturnieks
BACKGROUND: Although step training improves the ability of quick stepping, some home-based step training systems train limited stepping directions and may cause harm by reducing stepping performance in untrained directions. This study examines the possible transfer effects of step training on stepping performance in untrained directions in older people. METHODS: Fifty four older adults were randomized into: forward step training (FT); lateral plus forward step training (FLT); or no training (NT) groups...
February 21, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28257866/expression-of-the-vascular-endothelial-growth-factor-system-vegf-in-the-porcine-oviduct-during-the-estrous-cycle
#8
O López Albors, F Olsson, A B Llinares, H Gutiérrez, R Latorre, E Candanosa, A Guillén-Martínez, M J Izquierdo-Rico
The expression and localization of VEGFA and its main receptors Flt-1 and KDR is characterized in the oviduct throughout the porcine estrous cycle. Oviducts were sampled from sows at early follicular, late follicular, early luteal and late luteal stages of the estrous cycle and a segment from the mid portion of the ampulla and isthmus studied by real time RT-PCR and quantitative immunohistochemistry. The expression of the three components of the VEGF system was continuous, although differences were observed depending on the oviduct portion, the stage of the estrous cycle and the histological layer...
April 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28251571/survivin-a-radiogenetic-promoter-for-glioblastoma-viral-gene-therapy-independently-from-carg-motifs
#9
George E Naoum, Zeng B Zhu, Donald J Buchsbaum, David T Curiel, Waleed O Arafat
BACKGROUND: Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation. AIM: To select a potent radiation inducible promoter in the context of brain tumors and to investigate if CArG radio responsive motifs or other elements in the promoter nucleotide sequences can correlate to its response to radiation. METHODS: To select initial candidates for promoter inducible elements, the levels of mRNA expression of six different promoters were assessed using Quantitative RTPCR in D54 MG cells before and after radiation exposure...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28243610/pet-imaging-of-neurogenic-activity-in-the-adult-brain-toward-in-vivo-imaging-of-human-neurogenesis
#10
Yasuhisa Tamura, Yosky Kataoka
Neural stem cells are present in 2 neurogenic regions, the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG), and continue to generate new neurons throughout life. Adult hippocampal neurogenesis is linked to a variety of psychiatric disorders such as depression and anxiety, and to the therapeutic effects of antidepressants, as well as learning and memory. In vivo imaging for hippocampal neurogenic activity may be used to diagnose psychiatric disorders and evaluate the therapeutic efficacy of antidepressants...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28180966/an-update-on-the-role-of-pet-ct-and-pet-mri-in-ovarian-cancer
#11
REVIEW
Benjapa Khiewvan, Drew A Torigian, Sahra Emamzadehfard, Koosha Paydary, Ali Salavati, Sina Houshmand, Thomas J Werner, Abass Alavi
This review article summarizes the role of PET/CT and PET/MRI in ovarian cancer. With regard to the diagnosis of ovarian cancer, the presence of FDG uptake within the ovary of a postmenopausal woman raises the concern for ovarian cancer. Multiple studies show that FDG PET/CT can detect lymph node and distant metastasis in ovarian cancer with high accuracy and may, therefore, alter the management to obtain better clinical outcomes. Although PET/CT staging is superior for N and M staging of ovarian cancer, its role is limited for T staging...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28131097/downregulation-of-indoleamine-2-3-dioxygenase-expression-in-the-villous-stromal-endothelial-cells-of-placentas-with-preeclampsia
#12
Naoyuki Iwahashi, Madoka Yamamoto, Sakiko Nanjo, Saori Toujima, Sawako Minami, Kazuhiko Ino
INTRODUCTION: Previous studies have shown that indoleamine 2, 3-dioxygenase (IDO), an immunosuppressive enzyme that converts tryptophan to kynurenine, is expressed in the placenta and might play a role in the maintenance of pregnancy, although its associations with the pathogeneses of preeclampsia (PE) and fetal growth restriction (FGR) remain unclear. The objective of this study was to investigate the differences in IDO expression among normal, PE, and FGR placentas, and the associations between IDO expression and clinical symptoms, or the expression of fms-like tyrosine kinase receptor-1 (Flt-1)...
January 23, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28104392/scutellarein-antagonizes-the-tumorigenesis-by-modulating-cytokine-vegf-mediated-neoangiogenesis-and-dff-40-actuated-nucleosomal-degradation
#13
Prabhu Thirusangu, V Vigneshwaran, B R Vijay Avin, H Rakesh, H M Vikas, B T Prabhakar
Neoplastic cells often reside in distinctive tumor hypoxia armed with a series of adaptive responses including oxidative stress, defective apoptotic machinery and neoangiogenesis, through that further confer cell survival improvement. Plants still acts as reservoir of natural chemicals to provide newer active pharmacophores. Scutellarein is flavones which has wide range of pharmacophoral effects. In our current research, scutellarein employed for targeting oxidative stress mediated tumor angiogenesis and apoptotic nuclear fragmentation...
February 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28102569/human-%C3%AE-defensin-3-increases-the-tlr9-dependent-response-to-bacterial-dna
#14
Sarah L McGlasson, Fiona Semple, Heather MacPherson, Mohini Gray, Donald J Davidson, Julia R Dorin
Human β-defensin 3 (hBD3) is a cationic antimicrobial peptide with potent bactericidal activity in vitro. HBD3 is produced in response to pathogen challenge and can modulate immune responses. The amplified recognition of self-DNA by human plasmacytoid dendritic cells has been previously reported, but we show here that hBD3 preferentially enhances the response to bacterial DNA in mouse Flt-3 induced dendritic cells (FLDCs) and in human peripheral blood mononuclear cells. We show the effect is mediated through TLR9 and although hBD3 significantly increases the cellular uptake of both E...
January 19, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28102506/a-comparison-of-flt-to-fdg-pet-ct-in-the-early-assessment-of-chemotherapy-response-in-stages-ib-iiia-resectable-nsclc
#15
John P Crandall, Abdel K Tahari, Rosalyn A Juergens, Julie R Brahmer, Charles M Rudin, Giuseppe Esposito, Deepa S Subramaniam, Michael V Knopp, Nathan C Hall, Prateek Gajwani, Jeffrey P Leal, Martin A Lodge, Joo H O, Edward W Gabrielson, Lalitha K Shankar, Richard L Wahl
BACKGROUND: The aim of this study was to compare the percentage change in (18)F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 computed tomography (CT) as responders or non-responders after two cycles of therapy. Change in (18)F-fluorodeoxyglucose (FDG) uptake was also compared between these time points. Nine patients with newly diagnosed, operable, non-small cell lung cancer (NSCLC) were imaged with FDG positron emission tomography/CT (PET), FLT PET/CT, and CT at baseline, following one cycle of neoadjuvant therapy (75 mg/m(2) docetaxel + 75 mg/m(2) cisplatin), and again after the second cycle of therapy...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28101193/-18-f-flt-and-18-f-fdg-pet-ct-imaging-in-the-evaluation-of-early-therapeutic-effects-of-chemotherapy-on-walker-256-tumor-bearing-rats
#16
Weina Xu, Shupeng Yu, Jun Xin, Qiyong Guo
The present study aimed to evaluate the early therapeutic effects of chemotherapy on Walker 256 tumor-bearing Wistar rats via F-18-fluoro-3'-deoxy-3'-L-fluorothymidine ((18)F-FLT) and F-18-fluoro-deoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) imaging. Walker 256 tumor-bearing Wistar rats were subjected to (18)F-FLT and (18)F-FDG PET-CT imaging prior to and 24 and 48 h after epirubicin chemotherapy. (18)F-FLT and (18)F-FDG uptake [tumor/muscle (T/M)], the percentage of injected dose per gram (% ID/g), and the Ki-67 labeling index (LI-Ki-67) were quantitatively determined for each rat prior to and following epirubicin chemotherapy...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28091565/-18-f-flt-and-18-f-fdg-pet-ct-in-predicting-response-to-chemoradiotherapy-in-nasopharyngeal-carcinoma-preliminary-results
#17
Shi Qi, Yang Zhongyi, Zhang Yingjian, Hu Chaosu
The purpose of this study was to explore the feasibility of (18)F-Fluorothymidine ((18)F-FLT) and (18)F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in predicting treatment response of nasopharyngeal carcinoma (NPC). Patients with NPC of Stage II-IVB were prospectively enrolled, receiving 2 cycles of neoadjuvant chemotherapy (NACT), followed by concurrent chemoradiotherapy. Each patient underwent pretreatment and post-NACT FLT PET/CT and FDG PET/CT. Standard uptake values (SUV) and tumor volume were measured...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081344/peripheral-flt-3-ligand-levels-as-a-pathobiological-parameter-duringthe-clinical-course-of-acute-myeloid-leukemia
#18
Memduh Şahin, İbrahim Celalettin Haznedaroğlu, Demircan Özbalcı
BACKGROUND/AIM: FLT-3 ligand is a growth factor affecting the hematopoietic lineage. The aim of this study was to evaluate the variability of peripheral FLT-3 ligand during the clinical course of acute myeloid leukemia (AML) patients. MATERIALS AND METHODS: Twenty-four patients were enrolled in this study in order to assess alterations in the circulating levels of FLT-3 ligand during the clinical course of AML. RESULTS: We studied the association in the diagnostic period between the FLT-3 ligand and peripheral blood cells together with serum electrolytes...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28060742/overexpression-of-lncrna-anril-up-regulates-vegf-expression-and-promotes-angiogenesis-of-diabetes-mellitus-combined-with-cerebral-infarction-by-activating-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model
#19
Bo Zhang, Dan Wang, Tie-Feng Ji, Lei Shi, Jin-Lu Yu
OBJECTIVE: This study aimed to explore the effects of lncRNA ANRIL on vascular endothelial growth factor (VEGF) and angiogenesis in diabetes mellitus (DM) combined with cerebral infarction (CI) through NF-κB signaling pathway. METHODS: Adult male Wistar rats were randomly divided into control group and DM + CI group, and the DM + CI group were subdivided into Vector, shANRIL, PDTC, pcDNA-ANRIL, and pcDNA-ANRIL + PDTC groups. VEGF and FMS-like tyrosine kinase (FLT-1) expressions were measured by immunohistochemistry and endothelium dependent microvessel density (MVD) was detected by differentiation 31 (CD31) and para-amiuosalicylic acid (PAS) double staining...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28048721/su-f-j-222-using-pet-imaging-to-evaluate-proliferation-and-blood-flow-in-irradiated-and-non-irradiated-bone-marrow-1-year-after-chemoradiation-therapy
#20
S McGuire, L Ponto, Y Menda
PURPOSE: To compare proliferation and blood flow in pelvic and thoracic bone marrow 1 year after pelvic chemoradiation. METHODS: Sixteen pelvic cancer patients were enrolled in an IRB-approved protocol to acquire FLT PET images during radiation therapy simulation (baseline) and 1 year after chemoradiation therapy. Three subjects also had optional O-15 water PET images acquired 1 year after chemoradiation therapy. Baseline FLT PET images were used to create IMRT plans to spare pelvic bone marrow identified as regions with FLT SUV ≥ 2 without compromising PTV coverage or OAR sparing...
June 2016: Medical Physics
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