Mehrdad Moetamani-Ahmadi, Amir Mahmoud Ahmadzade, Maryam Alaei, Nima Zafari, Zhara Negahbanzaferanloo, Ali Mohammad Pourbagher-Shahri, Fatemeh Forouzanfar, Hamid Fiuji, Hanie Mahaki, Majid Khazaei, Ibrahim Saeed Gataa, Gordon A Ferns, Godefridus J Peters, Jyotsna Batra, Alfred King-Yin Lam, Elisa Giovannetti, Hamid TanzadePanah, Amir Avan
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious adverse effect of cisplatin. The current study aimed to determine whether PEGylated nanoliposomal cisplatin can limit CIPN in an animal model. METHODS: Cisplatin-loaded PEGylated liposome nanoparticles (Cis-PL) were produced as a combination of lecithin, cholesterol, and DSPE-mPEG2000 in a molar ratio of 50:45:5 and were characterized by polydispersity index (PDI), zeta potential, Field emission scanning electron microscopy (FESEM) analysis, as well as encapsulation efficiency (EE)...
January 22, 2024: International Journal of Pharmaceutics