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JOURNAL ARTICLE
Eleni Poptsi, Despina Moraitou, Emmanouil Tsardoulias, Andreas L Symeonidis, Vasileios Papaliagkas, Magdalini Tsolaki
BACKGROUND: The diagnosis of the minor neurocognitive diseases in the clinical course of dementia before the clinical symptoms' appearance is the holy grail of neuropsychological research. The R4Alz battery is a novel and valid tool that was designed to assess cognitive control in people with minor cognitive disorders. The aim of the current study is the R4Alz battery's extension (namely R4Alz-R), enhanced by the design and administration of extra episodic memory tasks, as well as extra cognitive control tasks, towards improving the overall R4Alz discriminant validity...
January 17, 2023: Diagnostics
#22
JOURNAL ARTICLE
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Gambling is common and there is growing concern about its public health implications. Little is known about how gambling differs in people with minority sexual identities. We sought to understand whether lesbian, gay, and bisexual (LGB) individuals differ from non-LGB individuals in terms of gambling and associated characteristics. METHODS: A total of 534 participants age 18 to 29 who gambled at least 5 times in the preceding year undertook clinical and neurocognitive evaluations...
February 2023: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
#23
JOURNAL ARTICLE
Taishiro Kishimoto, Hironobu Nakamura, Yoshinobu Kano, Yoko Eguchi, Momoko Kitazawa, Kuo-Ching Liang, Koki Kudo, Ayako Sento, Akihiro Takamiya, Toshiro Horigome, Toshihiko Yamasaki, Yuki Sunami, Toshiaki Kikuchi, Kazuki Nakajima, Masayuki Tomita, Shogyoku Bun, Yuki Momota, Kyosuke Sawada, Junichi Murakami, Hidehiko Takahashi, Masaru Mimura
INTRODUCTION: Psychiatric disorders are diagnosed through observations of psychiatrists according to diagnostic criteria such as the DSM-5. Such observations, however, are mainly based on each psychiatrist's level of experience and often lack objectivity, potentially leading to disagreements among psychiatrists. In contrast, specific linguistic features can be observed in some psychiatric disorders, such as a loosening of associations in schizophrenia. Some studies explored biomarkers, but biomarkers have yet to be used in clinical practice...
2022: Frontiers in Psychiatry
#24
JOURNAL ARTICLE
Amelia Luckett, Muhammad Yousef, Cynthia Tifft, Kisha Jenkins, Andrew Smith, Andrea Munoz, Rachel Quimby, Forbes D Porter, An Ngoc Dang Do
Natural history studies of pediatric rare neurometabolic diseases are important to understand disease pathophysiology and to inform clinical trial outcome measures. Some data collections require sedation given participants' age and neurocognitive impairment. To evaluate the safety of sedation for research procedures, we reviewed medical records between April 2017 and October 2019 from a natural history study for CLN3 (NCT03307304) and one for GM1 gangliosidosis (NCT00029965). Twenty-two CLN3 individuals underwent 28 anesthetic events (age median 11...
December 2, 2022: American Journal of Medical Genetics. Part A
#25
JOURNAL ARTICLE
Ann-Katrin Schild, Yasemin Goereci, Daniel Scharfenberg, Kim Klein, Joachim Lülling, Dix Meiberth, Finja Schweitzer, Sophie Stürmer, Philip Zeyen, Derya Sahin, Gereon R Fink, Frank Jessen, Christiana Franke, Oezguer A Onur, Josef Kessler, Clemens Warnke, Franziska Maier
BACKGROUND: A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. METHODS: Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered...
November 23, 2022: Journal of Neurology
#26
JOURNAL ARTICLE
Ilex Beltran-Najera, Jennifer L Thompson, Anastasia Matchanova, Steven Paul Woods
There are many obstacles to screening for HIV-associated neurocognitive disorders (HAND), including the influence of various sociodemographic effects on screening measures. This study examined possible racial bias on the HIV Dementia Scale (HDS) in screening for HAND among 39 Black and 84 White persons living with HIV (PLWH). Black PLWH had significantly lower raw HDS scores than White PLWH, which was mediated by lower oral word reading scores. Nevertheless, HDS scores were comparably predictive of clinical HAND diagnoses for Black and White PLWH as determined by a comprehensive battery; overall, individuals who failed the HDS were three times as likely to have HAND as compared to those who performed within normal limits (sensitivity = ...
October 31, 2022: AIDS Care
#27
REVIEW
Virgile Clergue-Duval, Laurent Coulbault, Frank Questel, Nicolas Cabé, Alice Laniepce, Clément Delage, Céline Boudehent, Vanessa Bloch, Shailendra Segobin, Mickael Naassila, Anne-Lise Pitel, Florence Vorspan
Alcohol use is a leading cause of mortality, brain morbidity, neurological complications and minor to major neurocognitive disorders. Alcohol-related neurocognitive disorders are consecutive to the direct effect of chronic and excessive alcohol use, but not only. Indeed, patients with severe alcohol use disorders (AUD) associated with pharmacological dependence suffer from repetitive events of alcohol withdrawal (AW). If those AW are not managed by adequate medical and pharmacological treatment, they may evolve into severe AW, or be complicated by epileptic seizure or delirium tremens (DT)...
October 21, 2022: Antioxidants (Basel, Switzerland)
#28
REVIEW
Chiara Cerami, Giulia Perini, Andrea Panzavolta, Matteo Cotta Ramusino, Alfredo Costa
Growing evidence supports the presence of social cognition deficits and social behavior alterations in major and minor neurocognitive disorders (NCDs). Even though the ability to identify socio-emotional changes has significantly improved in recent years, there is still no specific treatment available. Thus, we explored evidence of drug therapies targeting social cognition alterations in NCDs. Papers were selected according to PRISMA guidelines by searching on the PubMed and Scopus databases. Only papers reporting information on pharmacological interventions for the treatment of social cognition and/or social behavioral changes in major and/or minor NCDs were included...
September 30, 2022: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Christina Bruun Knudsen, Aja Neergaard Greve, Jens Richardt Møllegaard Jepsen, Rikke Lambek, Anna Krogh Andreassen, Lotte Veddum, Julie Marie Brandt, Maja Gregersen, Mette Falkenberg Krantz, Anne Søndergaard, Anders Helles Carlsen, Nanna Lawaetz Steffensen, Anette Faurskov Bundgaard, Birgitte Klee Burton, Anne Amalie Elgaard Thorup, Merete Nordentoft, Ole Mors, Vibeke Fuglsang Bliksted, Nicoline Hemager
BACKGROUND AND HYPOTHESIS: Subgroups with distinct levels of neurocognitive functioning exist in children of parents with schizophrenia or bipolar disorder. However, studies investigating the temporal stability of subgroup membership are currently lacking. We hypothesized that a minority of children at familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) would transition to a different neurocognitive subgroup from age 7 to 11 and that most transitions would be to a more impaired subgroup...
October 6, 2022: Schizophrenia Bulletin
#30
REVIEW
Emre Bora
Minor physical anomalies (MPAs) are markers of abnormalities in early foetal development and are well established findings in schizophrenia. It has been suggested that neurodevelopmental abnormalities might play a role not only in schizophrenia but also in bipolar disorder (BD). Therefore, according to neurodevelopmental theory of BD, one might expect increased prevalence of MPAs in BD. A meta-analysis of 11 studies was conducted to quantitatively review MPAs in BD in comparison to schizophrenia and healthy controls...
December 2022: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
#31
JOURNAL ARTICLE
Riccardo Manca, Anthony N Correro, Kathryn Gauthreaux, Jason D Flatt
Background: Sexual minority (SM) older adults experience mental health disparities. Psychiatric disorders and neuropsychiatric symptoms (NPS) are risk factors for cognitive decline. Although older people in same-sex (SSR) compared to mixed-sex relationships (MSR) perform more poorly on cognitive screening tests, prior studies found no differences in rates of dementia diagnosis or neuropsychological profiles. We sought to explore the role of NPS on neurocognitive outcomes for SM populations...
2022: Frontiers in Human Neuroscience
#32
JOURNAL ARTICLE
Kerith-Rae Dias, Colleen M Carlston, Laura E R Blok, Lachlan De Hayr, Urwah Nawaz, Carey-Anne Evans, Pinar Bayrak-Toydemir, Stephanie Htun, Ying Zhu, Alan Ma, Sally Ann Lynch, Catherine Moorwood, Karen Stals, Sian Ellard, Matthew N Bainbridge, Jennifer Friedman, John G Pappas, Rachel Rabin, Catherine B Nowak, Jessica Douglas, Theodore E Wilson, Maria J Guillen Sacoto, Sureni V Mullegama, Timothy Blake Palculict, Edwin P Kirk, Jason R Pinner, Matthew Edwards, Francesca Montanari, Claudio Graziano, Tommaso Pippucci, Bri Dingmann, Ian Glass, Heather C Mefford, Takeyoshi Shimoji, Toshimitsu Suzuki, Kazuhiro Yamakawa, Haley Streff, Christian P Schaaf, Anne M Slavotinek, Irina Voineagu, John C Carey, Michael F Buckley, Annette Schenck, Robert J Harvey, Tony Roscioli
PURPOSE: ZMYND8 encodes a multidomain protein that serves as a central interactive hub for coordinating critical roles in transcription regulation, chromatin remodeling, regulation of super-enhancers, DNA damage response and tumor suppression. We delineate a novel neurocognitive disorder caused by variants in the ZMYND8 gene. METHODS: An international collaboration, exome sequencing, molecular modeling, yeast two-hybrid assays, analysis of available transcriptomic data and a knockdown Drosophila model were used to characterize the ZMYND8 variants...
August 1, 2022: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#33
REVIEW
Katrin Skala, Thomas Trabi, Martin Fuchs, Ralf Gössler, Christian-Wilhelm Haas-Stockmair, Nicole Kriechbaumer, Monika Leitner, Nora Ortner, Melanie Reiter, Christian Müller, Wolfgang Wladika
BACKGROUND: Cannabis is the illegal drug most frequently used by Minors in Austria. Due to the gradual decriminalization and legalization that has taken place in many European countries in recent years, the ÖGKJP would like to take a balanced and scientifically based stand on the complex issue of cannabis use and abuse among young people. METHODS: The authors searched the medline for current studies using searches tailored to each specific subtopic. Furthermore, recognized compendiums were quoted...
July 28, 2022: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
#34
JOURNAL ARTICLE
Hsiao-Lun Kuo, Chun-Hung Chang, Wei-Fen Ma
OBJECTIVE: Dementia is a progressive neurocognitive disorder that currently affects approximately 50 million people globally and causes a heavy burden for their families and societies. This study analyzed mobile apps for dementia care in different languages and during the COVID-19 pandemic. METHODS: We searched PubMed, Cochrane Collaboration Central Register of Con-trolled Clinical Trials, Cochrane Systematic Reviews, Google Play Store, Apple App Store, and Huawei App Store for mobile applications for dementia care...
June 23, 2022: Healthcare (Basel, Switzerland)
#35
JOURNAL ARTICLE
Anna Tsiakiri, Pinelopi Vlotinou, Aikaterini Terzoudi, Ioannis Heliopoulos, Konstantinos Vadikolias
BACKGROUND: Prolonged periods of social deprivation, such as COVID-19-related lockdowns, are associated with deleterious effects on cognitive functions. OBJECTIVE: The aim of this study was to gauge the effect of prolonged social isolation on the cognitive function of older adults with neurocognitive disorders. METHODS: We recruited 125 older adults with minor or major neurocognitive disorders divided into two groups. The control group was tested at the first period of the study (October 2018-May 2019), whereas the experimental group was evaluated at the second chronological period of the study (October 2020-May 2021) during the second wave of COVID-19...
2022: Journal of Alzheimer's Disease: JAD
#36
JOURNAL ARTICLE
Christina J Herold, Li Kong, María Elena Ceballos, Johannes Schröder, Pablo Toro
Neurological soft signs (NSS) are a common feature of severe psychiatric disorders such as schizophrenia but are also prevalent in organic brain diseases like HIV-associated neurocognitive disorder (HAND) or Alzheimer's disease. While distinct associations between NSS, neurocognition, and cerebral regions were demonstrated in schizophrenia, these associations still have to be elucidated in HIV. Therefore, we investigated 36 persons with HIV of whom 16 were neurocognitively healthy and 20 were diagnosed with HAND...
April 2022: Journal of Neurovirology
#37
EDITORIAL
Rosalba Morese, Antonella Carassa, Sara Palermo
No abstract text is available yet for this article.
2022: Frontiers in Psychology
#38
JOURNAL ARTICLE
Caroline Masse, Gilles Chopard, Djamila Bennabi, Emmanuel Haffen, Pierre Vandel
Cognitive disorders are frequently found during late-life depression (LLD). Many cognitive functions may be concerned and can be explained by frontostriatal brain circuits and hippocampus dysfunctions partly through abnormalities related to cerebrovascular diseases. It seems important to distinguish between early and late onset depression, the cognitive characterisation and aetiopathogenesis of which differ in some respects. Cognitive impairment may represent markers of depression, but it is still unclear whether potential biomarkers of disease should be considered as markers of condition, trait or risk factors...
January 21, 2022: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
#39
JOURNAL ARTICLE
Fan Nils Yang, Shiva Hassanzadeh-Behbahani, Princy Kumar, David J Moore, Ronald J Ellis, Xiong Jiang
HIV-associated neurocognitive disorders (HAND) remain highly prevalent in people with HIV (PWH). Studies suggested that certain sociodemographic factors are associated with the risk of HAND in PWH. Here we investigated the impact of HIV infection and demographics on functional brain networks. One run of 8.5 min resting state functional MRI (fMRI) data was collected from 101 PWH (41-70 years old) and 40 demographically comparable controls. Functional connectivity (FC) was calculated using average wavelet coherence...
January 19, 2022: Journal of Neurovirology
#40
JOURNAL ARTICLE
Felipe Botero-Rodríguez, Ana Melisa Córdoba Sastoque, José Manuel Santacruz Escudero, Hernando Santamaría-García
BACKGROUND: The neuropsychiatric symptoms (NPS) in patients with neurocognitive disorders (NCD) increases the risk of exhibiting significant cognitive and functional decline. However, to the best of our knowledge, few studies have evaluated to what extent the presence of chronic and early NPS impacts cognition and functionality in patients with minor or major stages of NCD. OBJECTIVE: We aimed to assess the interplay between early and chronic NPS and cognitive and functional presentation of patients with mild and major forms of NCD...
2022: Journal of Alzheimer's Disease: JAD
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