keyword
MENU ▼
Read by QxMD icon Read
search

Major neurocognitive disorder

keyword
https://www.readbyqxmd.com/read/29660215/polygenic-risk-for-psychiatric-disorders-correlates-with-executive-function-in-typical-development
#1
Andrew J Schork, Timothy T Brown, Donald J Hagler, Wesley K Thompson, Chi-Hua Chen, Anders M Dale, Terry L Jernigan, Natacha Akshoomoff
Executive functions are a diverse and critical suite of cognitive abilities that are often disrupted in individuals with psychiatric disorders. Despite their moderate to high heritability, little is known about the molecular genetic factors that contribute to variability in executive function and how these factors may be related to those that predispose to psychiatric illness. We examined the relationship between polygenic risk scores built from large genome-wide association studies of psychiatric illness and executive functioning in typically developing children...
April 16, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29652529/neurocognitive-predictors-of-clinical-improvement-in-selective-serotonin-reuptake-inhibitor-treated-adolescents-with-major-depressive-disorder
#2
Fadi Maalouf, Rinad Bakhti, Hani Tamim, Safa Shehab, David Brent
OBJECTIVES: Numerous studies have suggested cognitive deficits as consistently associated with adolescent depression. No study to date, however, has assessed neurocognitive predictors of selective serotonin reuptake inhibitor (SSRI) treatment response in adolescents with depression. This study examined neurocognitive tasks at baseline as predictors of clinical improvement with SSRI treatment (fluoxetine) at week 6 and 12 in an adolescent population. METHODS: Adolescents with depression were recruited from a child and adolescent psychiatry outpatient clinic at a university medical center...
April 13, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29643258/prevalence-of-poststroke-neurocognitive-disorders-using-national-institute-of-neurological-disorders-and-stroke-canadian-stroke-network-vascog-criteria-vascular-behavioral-and-cognitive-disorders-and-optimized-criteria-of-cognitive-deficit
#3
Mélanie Barbay, Hervé Taillia, Claudine Nédélec-Ciceri, Flavie Bompaire, Camille Bonnin, Jérôme Varvat, Françoise Grangette, Momar Diouf, Emmanuel Wiener, Jean-Louis Mas, Martine Roussel, Olivier Godefroy
BACKGROUND AND PURPOSE: The prevalence of poststroke neurocognitive disorder (NCD) has yet to be accurately determined. The primary objective of the present study was to optimize operationalization of the criterion for NCD by using an external validity criterion. METHODS: The GRECOG-VASC cohort (Groupe de Réflexion pour l'Évaluation Cognitive Vasculaire) of 404 stroke patients with cerebral infarct (91.3%) or hemorrhage (18.7%) was assessed 6 months poststroke and 1003 healthy controls, with the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network standardized battery...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29613944/neurocognitive-effects-of-repetitive-transcranial-magnetic-stimulation-with-a-2-coil-device-in-treatment-resistant-major-depressive-disorder
#4
Brian C Kavanaugh, Scott T Aaronson, Gregory N Clarke, Paul E Holtzheimer, Clark W Johnson, William M McDonald, M Bret Schneider, Linda L Carpenter
BACKGROUND: Neurocognitive dysfunction is an understudied and undertreated aspect of psychiatric research and treatment. There is emerging evidence to suggest that repetitive transcranial magnetic stimulation (rTMS) may possess neurocognition-enhancing capabilities. METHODS: This study examined the neurocognitive data from a randomized, double-blind, sham-controlled trial of an investigational 2-coil rTMS device in antidepressant treatment or treatment-intolerant major depressive disorder patients...
April 2, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29604980/imaging-studies-of-the-hiv-infected-brain
#5
Linda Chang, Dinesh K Shukla
Human immunodeficiency virus (HIV) enters the brain early after infecting humans and may remain in the central nervous system despite successful antiretroviral treatment. Many neuroimaging techniques were used to study HIV+ patients with or without opportunistic infections. These techniques assessed abnormalities in brain structures (using computed tomography, structural magnetic resonance imaging (MRI), diffusion MRI) and function (using functional MRI at rest or during a task, and perfusion MRI with or without a contrast agent)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29594984/in-vivo-characterization-of-macrophage-tropic-simian-immunodeficiency-virus-molecular-clones-in-rhesus-macaques
#6
Sanjeev Gumber, Praveen Kumar Amancha, Po-Jen Yen, Francois Villinger, Dana Gabuzda, Siddappa N Byrareddy
Macrophages are a major target of HIV/SIV infection and play an important role in pathogenesis by serving as viral reservoirs in the central nervous system. Previously, a unique early SIVmac251 envelope (Env) variant, deSIV147 was cloned from blood of a rhesus macaque with rapid disease progression and SIV-associated encephalitis. Here, we show that infectious molecular clone deSIV147 caused systemic infection in rhesus macaques following intravenous or intrarectal exposure. Next, we inoculated deSIV147 into macaques depleted of CD4+ T cells and found that animals were SIV-positive, with high plasma and CSF viral loads...
March 28, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29578037/cocaine-evokes-a-profile-of-oxidative-stress-and-impacts-innate-antiviral-response-pathways-in-astrocytes
#7
Irma E Cisneros, Mert Erdenizmenli, Kathryn A Cunningham, Slobodan Paessler, Kelly T Dineley
HIV-1 and Zika virus (ZIKV) represent RNA viruses with neurotropic characteristics. Infected individuals suffer neurocognitive disorders aggravated by environmental toxins, including drugs of abuse such as cocaine, exacerbating HIV-associated neurocognitive disorders through a combination of astrogliosis, oxidative stress and innate immune signaling; however, little is known about how cocaine impacts the progression of ZIKV neural perturbations. Impaired innate immune signaling is characterized by weakened antiviral activation of interferon signaling and alterations in inflammatory signaling, factors contributing to cognitive sequela associated with cocaine in HIV-1/ZIKV infection...
March 22, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29558961/apolipoprotein-e-isoform-dependently-affects-tat-mediated-hiv-1-ltr-transactivation
#8
Nabab Khan, Gaurav Datta, Jonathan D Geiger, Xuesong Chen
BACKGROUND: Apolipoprotein E (ApoE) is the major carrier protein that mediates the transport and delivery of cholesterol and other lipids in the brain. Three isoforms of ApoE (ApoE2, ApoE3, ApoE4) exist in humans, and their relative expression levels impact HIV-1 infection, HIV-1/AIDS disease progression, and cognitive decline associated with HIV-1-associated neurocognitive disorder. Because HIV-1 Tat, a viral protein essential for HIV-1 replication, can bind to low-density lipoprotein receptor-related protein 1 (LRP1) that controls ApoE uptake in the brain, we determined the extent to which different isoforms of ApoE affected Tat-mediated HIV-1 LTR transactivation...
March 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29551622/treatment-of-behavior-disturbances-with-ketamine-in-a-patient-diagnosed-with-major-neurocognitive-disorder
#9
Douglas Steenblock
A 77-year-old woman who had been previously diagnosed with a major neurocognitive disorder became highly agitated and aggressive in a long-term care facility. She did not respond to intramuscular (IM) haloperidol plus lorazepam and had to be transported to the local emergency department (ED). In the ambulance, she remained highly agitated and was given 200 mg IM ketamine. Within minutes of receiving this, she de-escalated dramatically with no apparent adverse effects and remained stable for several days. Although ketamine has been used recently in pre-hospital settings and EDs to reduce agitated behavior, there has been little if any investigation of its potential for reducing behavior disturbances in patients who suffer from major neurocognitive disorders...
February 26, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29549313/astrocytic-metabolic-switch-is-a-novel-etiology-for-cocaine-and-hiv-1-tat-mediated-neurotoxicity
#10
Kalimuthusamy Natarajaseenivasan, Bianca Cotto, Santhanam Shanmughapriya, Alyssa A Lombardi, Prasun K Datta, Muniswamy Madesh, John W Elrod, Kamel Khalili, Dianne Langford
Calcium (Ca2+ ) dynamics and oxidative signaling control mitochondrial bioenergetics in the central nervous system, where astrocytes are a major energy source for neurons. Cocaine use exacerbates HIV-associated neurocognitive disorders, but little is known about disruptions in astrocyte metabolism in this context. Our data show that the HIV protein Tat and cocaine induce a metabolic switch from glucose to fatty acid oxidation in astrocytes, thereby limiting lactate transport to neurons. Mechanistic analyses revealed increased Mitochondrial Ca2+ Uniporter (MCU)-mediated Ca2+ uptake in astrocytes exposed to Tat and cocaine due to oxidation of MCU...
March 16, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29527471/task-free-spectral-eeg-dynamics-track-and-predict-patient-recovery-from-severe-acquired-brain-injury
#11
R L van den Brink, S Nieuwenhuis, G J M van Boxtel, G van Luijtelaar, H J Eilander, V J M Wijnen
For some patients, coma is followed by a state of unresponsiveness, while other patients develop signs of awareness. In practice, detecting signs of awareness may be hindered by possible impairments in the patient's motoric, sensory, or cognitive abilities, resulting in a substantial proportion of misdiagnosed disorders of consciousness. Task-free paradigms that are independent of the patient's sensorimotor and neurocognitive abilities may offer a solution to this challenge. A limitation of previous research is that the large majority of studies on the pathophysiological processes underlying disorders of consciousness have been conducted using cross-sectional designs...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29522770/therapeutic-evaluation-of-solid-lipid-nanoparticle-of-quercetin-in-pentylenetetrazole-induced-cognitive-impairment-of-zebrafish
#12
Narahari Rishitha, Arunachalam Muthuraman
BACKGROUND: Quercetin is a major flavonoid in various plants. It possesses the multiple pharmacological actions like vascular integrity and regulatory action of the blood-brain barrier. AIMS: The present study is focused on evaluating the role of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced cognitive impairment of Danio rerio species. MAIN METHODS: The memory impairment of zebrafish was induced by exposing of PTZ in 7...
March 6, 2018: Life Sciences
https://www.readbyqxmd.com/read/29517259/age-sex-and-education-specific-norms-for-an-extended-cerad-neuropsychological-assessment-battery-results-from-the-population-based-life-adult-study
#13
Tobias Luck, Alexander Pabst, Francisca S Rodriguez, Matthias L Schroeter, Veronica Witte, Andreas Hinz, Anja Mehnert, Christoph Engel, Markus Loeffler, Joachim Thiery, Arno Villringer, Steffi G Riedel-Heller
OBJECTIVE: To provide new age-, sex-, and education-specific reference values for an extended version of the well-established Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB) that additionally includes the Trail Making Test and the Verbal Fluency Test-S-Words. METHOD: Norms were calculated based on the cognitive performances of n = 1,888 dementia-free participants (60-79 years) from the population-based German LIFE-Adult-Study...
March 8, 2018: Neuropsychology
https://www.readbyqxmd.com/read/29510692/are-dementia-with-lewy-bodies-and-parkinson-s-disease-dementia-the-same-disease
#14
Kurt A Jellinger, Amos D Korczyn
BACKGROUND: Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), which share many clinical, neurochemical, and morphological features, have been incorporated into DSM-5 as two separate entities of major neurocognitive disorders with Lewy bodies. Despite clinical overlap, their diagnosis is based on an arbitrary distinction concerning the time of onset of motor and cognitive symptoms, namely as early cognitive impairment in DLB and later onset following that of motor symptoms in PDD...
March 6, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29497113/tolerance-of-chronic-hdaci-treatment-for-neurological-visceral-and-lung-niemann-pick-type-c-disease-in-mice
#15
Md Suhail Alam, Bruce Cooper, Joseph D Farris, Kasturi Haldar
Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use to treat neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo), 2-hydroxypropyl-beta-cyclodextrin (HPBCD) and polyethylene glycol (PEG) 400 improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann-Pick Type C (NPC) disease...
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29492246/an-update-on-the-safety-of-current-therapies-for-alzheimer-s-disease-focus-on-rivastigmine
#16
REVIEW
Rita Khoury, Jayashree Rajamanickam, George T Grossberg
Alzheimer's disease (AD) is the most common cause of major neurocognitive disorders worldwide. Despite all research efforts, therapeutic options for AD are still limited to two drug classes: cholinesterase inhibitors (ChEIs) and the NMDA-receptor antagonist memantine. Donepezil, rivastigmine and galantamine are the three ChEIs FDA-approved as first-line treatment for AD. Although they share the same mode of action, they differ in terms of their pharmacologic characteristics and route of administration, which can impact their safety and tolerability profile...
March 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29482662/bright-light-therapy-versus-physical-exercise-to-prevent-co-morbid-depression-and-obesity-in-adolescents-and-young-adults-with-attention-deficit-hyperactivity-disorder-study-protocol-for-a-randomized-controlled-trial
#17
Jutta S Mayer, Katharina Hees, Juliane Medda, Oliver Grimm, Philip Asherson, Mariano Bellina, Michael Colla, Pol Ibáñez, Elena Koch, Antonio Martinez-Nicolas, Adrià Muntaner-Mas, Anna Rommel, Nanda Rommelse, Saskia de Ruiter, Ulrich W Ebner-Priemer, Meinhard Kieser, Francisco B Ortega, Johannes Thome, Jan K Buitelaar, Jonna Kuntsi, J Antoni Ramos-Quiroga, Andreas Reif, Christine M Freitag
BACKGROUND: The risk for major depression and obesity is increased in adolescents and adults with attention-deficit / hyperactivity disorder (ADHD) and adolescent ADHD predicts adult depression and obesity. Non-pharmacological interventions to treat and prevent these co-morbidities are urgently needed. Bright light therapy (BLT) improves day-night rhythm and is an emerging therapy for major depression. Exercise intervention (EI) reduces obesity and improves depressive symptoms. To date, no randomized controlled trial (RCT) has been performed to establish feasibility and efficacy of these interventions targeting the prevention of co-morbid depression and obesity in ADHD...
February 26, 2018: Trials
https://www.readbyqxmd.com/read/29481997/biased-neurocognitive-self-perception-in-depressive-and-in-healthy-persons
#18
Christine Schwert, Maren Stohrer, Steffen Aschenbrenner, Matthias Weisbrod, Annette Schröder
BACKGROUND: Cognitive deficits across several domains and subjective complaints about cognition are prevalent in major depression disorder (MDD). Nevertheless, subjective and objective cognitive functions show no associations. However, research concerning the extent and direction of discrepancy is rare. The present study examined the relationship and discrepancy between subjective and objective cognitive deficits both in patients with MDD and healthy individuals. METHOD: Outpatients with MDD (n = 102) and a healthy control group (n = 88) were assessed with a neuropsychological test battery and completed a questionnaire for the self-assessment of cognitive performance (FLei) concerning the domains of attention, memory, and executive functions...
February 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29432242/epileptic-encephalopathies
#19
Shaun A Hussain
PURPOSE OF REVIEW: This article reviews the manifestations and treatment of the epileptic encephalopathies, which are a heterogeneous group of disorders characterized by both seizures and neurocognitive impairment. RECENT FINDINGS: Next-generation (exome- and genome-based) sequencing technologies are revolutionizing the identification of single-gene causes of epileptic encephalopathy but have only had a modest impact on patient-specific treatment decisions. The treatment of most forms of epileptic encephalopathy remains a particularly challenging endeavor, with therapeutic decisions chiefly driven by the electroclinical syndrome classification...
February 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29426395/research-opportunities-in-the-area-of-adults-with-alzheimer-s-disease-and-related-neurocognitive-disorders
#20
(no author information available yet)
The American Occupational Therapy Association (AOTA) Evidence-Based Practice Project has developed a table summarizing the research opportunities for adults with Alzheimer's disease and related major neurocognitive disorders. The table provides an overview of the state of current available evidence on interventions within the scope of occupational therapy practice and is based on the systematic reviews from the AOTA Practice Guidelines Series. Researchers, clinicians, and students can use this information in developing innovative research to answer important questions within the occupational therapy field...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
keyword
keyword
115549
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"