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https://www.readbyqxmd.com/read/28821472/surgical-findings-and-outcomes-in-premenopausal-breast-cancer-patients-undergoing-oophorectomy-a-multicenter-review-from-the-fellows-pelvic-research-network
#1
Lara F B Harvey, Vandana G Abramson, Jimena Alvarez, Christopher Destephano, Hye-Chun Hur, Katherine Lee, Patricia Mattingly, Beau Park, Carolyn Piszczek, Farinaz Seifi, Mallory Stuparich, Amanda Yunker
STUDY OBJECTIVE: Since publication of the Suppression of Ovarian Function Trial (SOFT) data, some women with premenopausal breast cancer have been recommended to undergo bilateral oophorectomy to facilitate breast cancer treatment with aromatase inhibitors. These women may be at higher risk of occult abdominal pathology than the general population. Our objective is to describe the procedures performed, intra-abdominal findings, and surgical pathology of this population. DESIGN: Multi-center retrospective chart review...
August 15, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28819841/microscale-laminar-vortices-for-high-purity-extraction-and-release-of-circulating-tumor-cells
#2
Soojung Claire Hur, James Che, Dino Di Carlo
Circulating tumor cells (CTCs) are disseminated tumor cells that reflect the tumors of origin and can provide a liquid biopsy that would potentially enable noninvasive tumor profiling, treatment monitoring, and identification of targeted treatments. Accurate and rapid purification of CTCs holds great potential to improve cancer care but the task remains technically challenging. Microfluidic isolation of CTCs within microscale vortices enables high-throughput and size-based purification of rare CTCs from bodily fluids...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28811522/the-lichen-secondary-metabolite-atranorin-suppresses-lung-cancer-cell-motility-and-tumorigenesis
#3
Rui Zhou, Yi Yang, So-Yeon Park, Thanh Thi Nguyen, Young-Woo Seo, Kyung Hwa Lee, Jae Hyuk Lee, Kyung Keun Kim, Jae-Seoun Hur, Hangun Kim
Lichens are symbiotic organisms that produce various secondary metabolites. Here, different lichen extracts were examined to identify secondary metabolites with anti-migratory activity against human lung cancer cells. Everniastrum vexans had the most potent inhibitory activity, and atranorin was identified as an active subcomponent of this extract. Atranorin suppressed β-catenin-mediated TOPFLASH activity by inhibiting the nuclear import of β-catenin and downregulating β-catenin/LEF and c-jun/AP-1 downstream target genes such as CD44, cyclin-D1 and c-myc...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808873/elevated-hu-antigen-receptor-hur-expression-is-associated-with-tumor-aggressiveness-and-poor-prognosis-but-not-with-cox-2-expression-in-invasive-breast-carcinoma-patients
#4
Constantinos Giaginis, Anastasia Sampani, Iolly Kotta-Loizou, Ioanna Giannopoulou, Eugene Danas, Ekaterini Politi, Gerasimos Tsourouflis, Gregorios Kouraklis, Efstratios Patsouris, Antonios Keramopoulos, Lydia Nakopoulou, Stamatios Theocharis
Hu-antigen R (HuR), a RNA-binding protein, is considered to play a crucial role in tumor development and progression by stabilizing or regulating a group of cellular mRNAs of cancer-related genes, such as cyclooxygenase-2 (COX-2). The present study aimed to evaluate the clinical significance of HuR and COX-2 expression in invasive breast carcinoma. HuR and COX-2 protein expression was assessed immunohistochemically on paraffin-embedded breast cancer tissue sections obtained from 121 patients and was statistically analyzed with clinicopathological parameters, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), as well as with tumor cells' proliferative capacity and overall and disease-free patients' survival...
August 14, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28808521/replicative-genetic-association-study-between-functional-polymorphisms-in-avpr1a-and-social-behavior-scales-of-autism-spectrum-disorder-in-the-korean-population
#5
So Young Yang, Soon Ae Kim, Gang Min Hur, Mira Park, Jong-Eun Park, Hee Jeong Yoo
BACKGROUND: Arginine vasopressin has been shown to affect social and emotional behaviors, which is mediated by the arginine vasopressin receptor (AVPR1A). Genetic polymorphisms in the AVPR1A promoter region have been identified to be associated with susceptibility to social deficits in autism spectrum disorder (ASD). We hypothesize that alleles of polymorphisms in the promoter region of AVPR1A may differentially interact with certain transcriptional factors, which in turn affect quantitative traits, such as sociality, in children with autism...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28807836/development-and-evaluation-of-the-automated-risk-assessment-system-for-multidrug-resistant-organisms-autoras-mdro
#6
Eun-Young Hur, Yinji Jin, Taixian Jin, Sun-Mi Lee
BACKGROUND: A high proportion of infections acquired in hospitals are caused by multidrug-resistant organisms (MDROs). The priority in MDRO prevention is to detect high-risk patients and implement preventive intervention as soon as possible. AIM: To develop an automated risk assessment system for MDROs (autoRAS-MDRO) to screen for patients at MDRO infection risk and evaluate the predictive validity of the autoRAS-MDRO. METHODS: Data for 4,200 variables were extracted from the electronic health records (EHRs) for constructing the MDRO risk-scoring algorithm, which was based on a logistic regression model...
August 11, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28802579/atorvastatin-prevents-endothelial-dysfunction-in-high-glucose-condition-through-skp2-mediated-degradation-of-foxo1-and-icam-1
#7
Jonghanne Park, Injoo Hwang, Sung-Jean Kim, Seock-Won Youn, Jin Hur, Hyo-Soo Kim
OBJECTIVE: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin has been reported to exert vasculo-protective action in diabetes. We investigated the vasculo-protective mechanism of atorvastatin by evaluating its effect on two major pathogenic molecules, FOXO1 and ICAM1, mediated by S-phase kinase-associated protein 2 (Skp2) in diabetic endothelial dysfunction. APPROACH AND RESULTS: [1] FOXO1: Hyperglycemic condition increased FOXO1 protein level in endothelial cells, which was reversed by atorvastatin...
August 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28802290/postoperative-oral-nutritional-supplementation-after-major-gastrointestinal-surgery-a-randomized-controlled-clinical-trial
#8
Seong-Ho Kong, Jun Seok Park, In Kyu Lee, Seung-Wan Ryu, Young-Kyu Park, Han-Kwang Yang, Sang-Uk Han, Ki-Young Yoon, Seung-Yong Jeong, Mi Ran Jeong, Dae Wook Hwang, Yun-Suhk Suh, Yoo-Seok Yoon, Kyung Won Seo, Ji Won Park, Chul-Su Byun, Hoon Hur, Hojeong Won, Yunhee Choi, Hyuk-Joon Lee
BACKGROUND AND OBJECTIVES: This study aimed to evaluate the efficacy of post-operative oral nutrition supplementation after major gastrointestinal surgery. METHODS AND STUDY DESIGN: A prospective randomized controlled trial was conducted to evaluate 174 subjects who were discharged within 2 weeks after major gastrointestinal surgery. The subjects in the study group were prescribed 400 ml/day of Encover® from the day of discharge for 8 weeks, but no supplementation was allowed in the control group...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28800484/characteristics-of-elemental-and-pb-isotopic-compositions-in-aerosols-pm10-2-5-at-the-ieodo-ocean-research-station-in-the-east-china-sea
#9
Sanghee Lee, Changhee Han, Daechol Shin, Soon Do Hur, Seong Joon Jun, Young-Taeg Kim, Do-Seong Byun, Sungmin Hong
A total of 82 aerosol samples (PM10-2.5) were collected from June 18, 2015 to October 1, 2016 at the remote sea site, the Ieodo Ocean Research Station (IORS), in the East China Sea. Samples were analyzed for 10 elements (Al, Fe, Cu, Zn, As, Mo, Cd, Sb, Tl, and Pb) as well as Pb isotopic composition to characterize temporal variations in elemental concentration levels, and to identify the potential source regions of atmospheric pollutants transported over the remote East China Sea. The results showed that the annual average element concentrations were lowest compared to those at different sites in East Asia, suggesting a very clean background area of IORS, with values ranging from 114 ng m(-3) for Al to 0...
August 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28799206/the-incidence-and-characteristics-of-3-month-mortality-after-intraoperative-cardiac-arrest-in-adults
#10
M Hur, H-C Lee, K H Lee, J-T Kim, C-W Jung, H-P Park
BACKGROUND: There is little information about clinical outcomes after intraoperative cardiac arrest (IOCA). We determined the incidence and characteristics of 3-month mortality after IOCA. METHODS: The electronic medical records of 238,648 adult surgical patients from January 2005 to December 2014 were reviewed retrospectively. Characteristics of IOCA were documented using the Utstein reporting template. RESULTS: IOCA occurred in 50 patients (21/100,000 surgeries)...
August 11, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28797089/therapeutic-response-assessment-using-3d-ultrasound-for-hepatic-metastasis-from-colorectal-cancer-application-of-a-personalized-3d-printed-tumor-model-using-ct-images
#11
Ye Ra Choi, Jung Hoon Kim, Sang Joon Park, Bo Yun Hur, Joon Koo Han
BACKGROUND & AIMS: To evaluate accuracy and reliability of three-dimensional ultrasound (3D US) for response evaluation of hepatic metastasis from colorectal cancer (CRC) using a personalized 3D-printed tumor model. METHODS: Twenty patients with liver metastasis from CRC who underwent baseline and after chemotherapy CT, were retrospectively included. Personalized 3D-printed tumor models using CT were fabricated. Two radiologists measured volume of each 3D printing model using 3D US...
2017: PloS One
https://www.readbyqxmd.com/read/28790173/hu-antigen-r-hur-multimerization-contributes-to-glioma-disease-progression
#12
Natalia Filippova, Xiuhua Yang, Subramaniam Ananthan, Anastasia Sorochinsky, James R Hackney, Zachery Gentry, Sejong Bae, Peter King, L Burt Nabors
Among primary brain cancers, gliomas are the most deadly and most refractory to current treatment modalities. Previous reports overwhelmingly support the role of the RNA-binding protein HuR as a positive regulator of glioma disease progression. HuR expression is consistently elevated in tumor tissues, and a cytoplasmic localization appears essential for HuR-dependent oncogenic transformation. In this manuscript, we report HuR aggregation (multimerization) in glioma and performed an analysis of this tumor-specific HuR protein multimerization in clinical brain tumor samples...
August 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28770455/feasibility-of-a-single-beat-prospective-ecg-gated-cardiac-ct-for-comprehensive-evaluation-of-aortic-valve-disease-using-a-256-detector-row-wide-volume-ct-scanner-an-initial-experience
#13
Jin Young Kim, Young Joo Suh, Suyon Chang, Dong Jin Im, Yoo Jin Hong, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Byoung Wook Choi
The aim of our study was to investigate the feasibility of single-beat prospective electrocardiogram (ECG)-gated cardiac computed tomography (CT) using a 256-detector row wide-volume CT scanner for functional and anatomical evaluation of the aortic valve (AV) and coronary arteries in patients with AV disease. A total of 50 patients who underwent cardiac CT scan with a wide-volume 256-detector row CT scanner for the evaluation of AV and aorta were retrospectively enrolled. Cardiac CT was performed using the prospective ECG-gated acquisition mode, and AV image quality was analyzed using a four-point grading system...
August 2, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28770422/depletion-of-beta-cell-intranuclear-rodlets-in-human-type-ii-diabetes
#14
Yi Yuan Zhou, Soufiane El Hallani, Fady Balaa, Waleed Mohammad, Douglas A Gray, John Woulfe
Intranuclear rodlets (INRs) are rod-shaped intranuclear bodies of unknown function present in the nuclei of pancreatic beta cells. Previous studies have demonstrated a significant depletion of INRs from beta cells in mouse models of type II diabetes, suggesting that they may have pathological significance. The objective of the present study was to determine whether beta cell INRs show quantitative alterations in human type II diabetes. In sections of non-neoplastic pancreas from 23 diabetic patients and 23 controls who had undergone complete or partial pancreatectomy, we detected a significant reduction in the proportion of INRs in insulin-immunoreactive beta cells...
August 2, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28765752/erratum-the-practice-pattern-of-percutaneous-coronary-intervention-in-korea-based-on-year-2014-cohort-of-korean-percutaneous-coronary-intervention-k-pci-registry
#15
Hyeon-Cheol Gwon, Dong Woon Jeon, Hyun-Jae Kang, Jae-Sik Jang, Duk-Woo Park, Dong-Ho Shin, Keon-Woong Moon, Jung-Sun Kim, Juhan Kim, Jang-Whan Bae, Seung-Ho Hur, Byung Ok Kim, Donghoon Choi, Kyoo-Rok Han, Hyo-Soo Kim
[This corrects the article on p. 320 in vol. 47, PMID: 28567082.].
July 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28761865/limitation-and-value-of-using-the-adenoma-detection-rate-for-colonoscopy-quality-assurance
#16
EDITORIAL
Jun Hur, Moo-Jun Baek
No abstract text is available yet for this article.
June 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28757384/znf509s1-downregulates-puma-by-inhibiting-p53k382-acetylation-and-p53-dna-binding
#17
Bu-Nam Jeon, Jae-Hyeon Yoon, Dohyun Han, Min-Kyeong Kim, Youngsoo Kim, Seo-Hyun Choi, Jiyang Song, Kyung-Sup Kim, Kunhong Kim, Man-Wook Hur
Expression of the POK family protein ZNF509L, and -its S1 isoform, is induced by p53 upon exposure to genotoxic stress. Due to alternative splicing of the ZNF509 primary transcript, ZNF509S1 lacks the 6 zinc-fingers and C-terminus of ZNF509L, resulting in only one zinc-finger. ZNF509L and -S1 inhibit cell proliferation by activating p21/CDKN1A and RB transcription, respectively. When cells are exposed to severe DNA damage, p53 activates PUMA (p53-upregulated modulator of apoptosis) transcription. Interestingly, apoptosis due to transcriptional activation of PUMA by p53 is attenuated by ZNF509S1...
July 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28753710/determinants-and-evaluation-of-nasal-airflow-perception
#18
Jasper Shen, Kevin Hur, Kai Zhao, Donald A Leopold, Bozena B Wrobel
No abstract text is available yet for this article.
August 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28750773/a-study-on-current-risk-assessments-and-guidelines-on-the-use-of-food-animal-products-derived-from-cloned-animals
#19
Sun Jin Hur
The author widely surveyed and analyzed the food safety issues, ethical issues, permits, and approval of animal products from animals cloned by somatic cell nuclear transfer worldwide. As a result of a 2-year survey, the author found that there is no evidence that meat and milk derived from cloned animals or their progeny pose a risk to food safety in terms of genotoxicity, adverse reproductive effects, or allergic reactions. Most countries have not approved meat and milk derived from cloned animals, and their progeny are entering the food supply...
July 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28750328/inactivation-efficiency-of-plasmid-encoded-antibiotic-resistance-genes-during-water-treatment-with-chlorine-uv-and-uv-h2o2
#20
Younggun Yoon, Hay Jung Chung, Doris Yoong Wen Di, Michael C Dodd, Hor-Gil Hur, Yunho Lee
This study assessed the inactivation efficiency of plasmid-encoded antibiotic resistance genes (ARGs) both in extracellular form (e-ARG) and present within Escherichia coli (intracellular form, i-ARG) during water treatment with chlorine, UV (254 nm), and UV/H2O2. A quantitative real-time PCR (qPCR) method was used to quantify the ARG damage to amp(R) (850 bp) and kan(R) (806 bp) amplicons, both of which are located in the pUC4K plasmid. The plate count and flow cytometry methods were also used to determine the bacterial inactivation parameters, such as culturability and membrane damage, respectively...
June 22, 2017: Water Research
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