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Jun-Hwan Kim, Jin-Young Kim, Lok-Ji Lim, Su Kyoung Kim, Hye Sung Choi, Young Baek Hur
Juvenile olive flounders, Paralichthys olivaceus (mean weight 2.69 ± 0.31 g), were raised in bio-floc and seawater for six months, these P. olivaceus (mean weight 280.1 ± 10.5 g, mean length 28.37 ± 2.3 cm) were exposed to different concentrations of waterborne nitrite (0, 25, 50, 100, and 200 mg NO2 - /L) for 7 days. None of the P. olivaceus individuals exposed to bio-floc and seawater containing waterborne nitrite concentrations of 200 mg/L for 7 days survived. Hematological parameters (hemoglobin and hematocrit) were significantly reduced by nitrite exposure...
June 11, 2018: Chemosphere
Jinghao Qin, Hongbing Shi, Yanjie Xu, Fang Zhao, Qing Wang
This study aims to explore the effects and related mechanisms of Tanshinone IIA in cervix carcinoma (CC) stemness-like cells migration, invasion, stemness and chemotherapeutical sensitivity. Here, we found that Tanshinone IIA suppressed CC stemness-like cells migration and invasion in a concentration- and time-dependent manner. And consistent results were obtained in CC cells stemness characterized as the decrease of CC stemness markers expression and cells spheroid formation ability. Mechanistically, we found that Tanshinone IIA suppressed RNA binding protein HuR translocation from nuclear to cytoplasm, and thus reduced YAP mRNAs stability and transcriptional activity...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Kyung Ho Kang, Chin Kook Rhee, Seoung Ju Park, Adnan Khan, Jinhyuk Na, Youngja H Park, Jae Jeong Shim
Purpose: Asthma-COPD overlap (ACO) is heterogeneous in nature and requires a unified diagnostic approach. We investigated the urinary levels of l-histidine, a precursor of histamine related to inflammatory responses, as a new candidate biomarker for diagnosing this condition. Patients and methods: We performed a prospective multicenter cohort study with retrospective analysis of 107 patients, who were divided into three groups: asthma, COPD, and ACO, according to the Spanish guidelines algorithm...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Hayoung Song, Xiangshu Dong, Hankuil Yi, Ju Young Ahn, Keunho Yun, Myungchul Song, Ching-Tack Han, Yoonkang Hur
For sustainable crop cultivation in the face of global warming, it is important to unravel the genetic mechanisms underlying plant adaptation to a warming climate and apply this information to breeding. Thermomorphogenesis and ambient temperature signaling pathways have been well studied in model plants, but little information is available for vegetable crops. Here, we investigated genes responsive to warming conditions from two Brassica rapa inbred lines with different geographic origins: subtropical (Kenshin) and temperate (Chiifu)...
June 11, 2018: International Journal of Molecular Sciences
Loan Thi Thanh Nguyen, Ja Yeong Jang, Tae Yoon Kim, Nan Hee Yu, Ae Ran Park, Seungki Lee, Chang-Hwan Bae, Joo Hong Yeo, Jae-Seoun Hur, Hae Woong Park, Jin-Cheol Kim
No abstract text is available yet for this article.
June 2018: Pesticide Biochemistry and Physiology
Hao Tang, Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin Jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, Zhou Songyang, Wenbin Ma, Yong Zhao, Xian Wang, Jinbiao Ma, Myriam Gorospe, Zhenyu Ju, Wengong Wang
Telomerase consists of the catalytic protein TERT and the RNA TERC. Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein HuR associates with TERC and promotes the assembly of the TERC/TERT complex by facilitating TERC C106 methylation. Dyskeratosis congenita (DC)-related TERC U100A mutation impair the association of HuR with TERC, thereby reducing C106 methylation. Two other TERC mutations linked to aplastic anemia and autosomal dominant DC, G107U, and GC107/108AG, likewise disrupt methylation at C106...
June 7, 2018: Nature Communications
Junguk Hur, Arzucan Özgür, Yongqun He
BACKGROUND: Adverse drug reactions (ADRs), also called as drug adverse events (AEs), are reported in the FDA drug labels; however, it is a big challenge to properly retrieve and analyze the ADRs and their potential relationships from textual data. Previously, we identified and ontologically modeled over 240 drugs that can induce peripheral neuropathy through mining public drug-related databases and drug labels. However, the ADR mechanisms of these drugs are still unclear. In this study, we aimed to develop an ontology-based literature mining system to identify ADRs from drug labels and to elucidate potential mechanisms of the neuropathy-inducing drugs (NIDs)...
June 7, 2018: Journal of Biomedical Semantics
Hyejin Jin, In-Hye Ham, Hye Jeong Oh, Cheong A Bae, Da Keun Lee, Young-Bae Kim, Sang-Yong Son, Yong-Joon Chwae, Sang-Uk Han, Rolf A Brekken, Hoon Hur
Discoidin domain receptor 1 (DDR1) is activated by fibrillar (triple-helical) collagens and collagen IV, which are major components of tumor stroma; thus, DDR1 might be critical mediator of communication between cancer cells and stroma. The aim of this study was to investigate the effect of DDR1 inhibition on stroma-induced peritoneal metastasis in gastric carcinoma (GC). We analyzed by immunohistochemistry the correlation between DDR1 expression and the pattern of recurrence in GC tissues from a previously characterized and established GC patient cohort...
June 4, 2018: Molecular Cancer Research: MCR
Jian Sun, Xianmin Gu, Nan Wu, Pengju Zhang, Yi Liu, Shujuan Jiang
BACKGROUND: Increasing evidence suggests that human antigen R (HuR) is involved in the epithelial-mesenchymal transition (EMT) process of several diseases. However, the role of HuR in EMT in the airway epithelial cells of patients with COPD remains unclear. METHODS: BEAS-2B cells were cultured and treated with 3%CSE. Western blotting, RT-PCR and immunofluoresence were used to detect the expression of HuR, ZEB-1. RNAi was used to suppress HuR expression. Then knockdown of HuR, RT-PCR and Western blotting showed that with siHuR-1 and siHuR-3, clear suppression of HuR expression was confirmed...
June 4, 2018: Respiratory Research
Haoran Yu, Chengjun Wu, Kersti Nilsson, Naoko Kajitani, Stefan Schwartz
Adenosine plays an important role in cell death and differentiation as well as in tumorigenesis and the intra- and extra-cellular levels range from nanomolar to millimolar levels under various physiological or pathophysiological conditions. Here we report that adenosine can activate HPV16 late gene expression in a dose- and time-dependent manner, but only in the presence of guanosine. This activation occurred within hours after addition of the nucleosides and was primarily dependent on the ENT1 nucleoside transporter protein...
June 1, 2018: Virology
Yera Hur, A Ra Cho, Sun Kim
PURPOSE: The purpose of this study was to explore the possibility of mentoring as an alternative to the current student support system based on our experiences of developing, operating, and evaluating a mentoring program. METHODS: In 2014 and 2015, a total of 29 mentoring pairs were selected to be trained as mentors and mentees. The mentoring program was evaluated by the following methods. First, at the end of the one-on-one mentoring program, the mentee made a presentation summarizing their experiences and submitted a portfolio...
June 2018: Korean Journal of Medical Education
Sachin Kumar Gupta, Hanseob Shin, Dukki Han, Hor-Gil Hur, Tatsuya Unno
The increased antibiotic resistance among microorganisms has resulted into growing interest for investigating the wastewater treatment plants (WWTPs) as they are reported to be the major source in the dissemination of antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) in the environment. In this study, we investigated the prevalence and persistence of ARGs and HMRGs as well as bacterial diversity and mobile genetic elements (MGEs) in influent and effluent at the WWTP in Gwangju, South Korea, using high-throughput sequencing based metagenomic approach...
June 2018: Journal of Microbiology / the Microbiological Society of Korea
Mikyoung Park, Mina Hur, Hanah Kim, Hyeong Nyeon Kim, Seung Wan Kim, Hee-Won Moon, Yeo-Min Yun, Hae Suk Cheong
No abstract text is available yet for this article.
May 29, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Umma Habiba, Takeshi Kuroshima, Aya Yanagawa-Matsuda, Tetsuya Kitamura, Afma Chowdhury, Jumond P Jehung, Elora Hossain, Hidehiko Sano, Yoshimasa Kitagawa, Masanobu Shindoh, Fumihiro Higashino
Human antigen R (HuR) is a RNA-binding protein, which binds to the AU-rich element (ARE) in the 3'-untranslated region (3'-UTR) of certain mRNA and is involved in the export and stabilization of ARE-mRNA. HuR constitutively relocates to the cytoplasm in many cancer cells, however the mechanism of intracellular HuR trafficking is poorly understood. To address this question, we examined the functional role of the cytoskeleton in HuR relocalization. We tested the effect of actin depolymerizing macrolide latrunculin A or myosin II ATPase activity inhibitor blebbistatin for HuR relocalization induced by the vasoactive hormone Angiotensin II in cancer and control normal cells...
May 25, 2018: Experimental Cell Research
Jung Hyun Kim, Sun Jin Hur, Dong Gyun Yim
This research was to evaluate microbial contamination levels in meat samples at hazard analysis critical control point (HACCP)-implemented processing plants that produce beef, pork, and chicken. During a period of about a year, a total of 178 samples (76 from beef, 89 from pork, and 13 from chicken) were obtained from raw materials (21.3%) and final products (78.7%). All samples were determined for each 25 g homogenized one. Samples were analyzed to determine the total aerobic plate count (APC), coliform count (CC), and E...
April 2018: Korean Journal for Food Science of Animal Resources
Seoyeon Yang, Ji-Yeon Lee, Ho Hur, Ji Hoon Oh, Myoung Hee Kim
Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes...
May 28, 2018: BMB Reports
Meilian Chen, Jinyoung Jung, Yun Kyung Lee, Jin Hur
Polar regions play unique roles in global overturning circulation, carbon cycling, and climate change. In this study, seawater dissolved organic matter (DOM) was characterized for the Chukchi Sea in the Arctic Ocean in the summer season. The seawater generally contains high concentrations of dissolved organic carbon (DOC, up to 92 μM C) and tyrosine-like fluorescence (up to 0.21 RU), and it was enriched with heteroatomic molecular formula with nitrogen-containing and sulfur-containing formulas counting 2246 (~41% of total identified molecular formula) and 1838 (~34%), respectively...
May 23, 2018: Science of the Total Environment
Francesca Bonino, Bjorn Steffensen, Zuhair Natto, Yong Hur, Lucrezia Paternò Holtzman, Hans-Peter Weber
BACKGROUND: It has been proposed that the presence of a zone of keratinized mucosa (KM) around implants is associated with less discomfort during brushing and improved esthetic outcomes. Therefore, mucogingival procedures have been recommended for patients with discomfort during brushing, and to enhance esthetic results around implants without KM. However, no study has systematically assessed and compared discomfort during brushing, patient soft tissue esthetic satisfaction and other clinical parameters between implants with and without KM...
May 26, 2018: Journal of Periodontology
William F Parker, Rebecca J Gorges, Y Nina Gao, Yudong Zhang, Kwan Hur, Robert D Gibbons
No abstract text is available yet for this article.
May 23, 2018: JAMA Psychiatry
Sun Young Cho, Mina Hur
No abstract text is available yet for this article.
September 2018: Annals of Laboratory Medicine
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