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Ji-Hyun Hur, Deok-Kee Kim
In this paper, we examine the highest possible performance level of graphene nanoribbon field effect transistors (GNRFETs) for wide range of operation voltages and device structure parameters such as width of graphene nanoribbon and gate length. To achieve this goal, we formulated a self-consistent non-equilibrium Green's function (NEGF) method in conjunction with the Poisson equation. We model the operation of nanometer sized GNRFETs of which GNR channels have finite bandgaps so that the GNRFET can operate as a switch...
February 19, 2018: Nanotechnology
Mohamed Najm, Fahad S Al-Ajlan, Mari E Boesen, Lisa Hur, Chi Kyung Kim, Enrico Fainardi, Michael D Hill, Andrew M Demchuk, Mayank Goyal, Ting Y Lee, Bijoy K Menon
In this brief report, computed tomography perfusion (CTP) thresholds predicting follow-up infarction in patients presenting 20 to 23 seconds and cerebral blood flow <5 to 7 ml/min-1/(100 g)-1 or relative cerebral blood flow <0.14 to 0.20 optimally predicted the final infarct. These thresholds are stricter than published thresholds.
February 19, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Hanah Kim, Mina Hur, Eunsin Bae, Kyung-A Lee, Woo-In Lee
BACKGROUND: Hepatitis B virus (HBV) nucleic acid amplification testing (NAAT) is important for the diagnosis and management of HBV infection. We evaluated the analytical performance of the cobas HBV NAAT (Roche Diagnostics GmbH, Mannheim, Germany) on the cobas 4800 System in comparison with COBAS AmpliPrep/COBAS TaqMan HBV Test (CAP/CTM HBV). METHODS: Precision was evaluated using three levels of cobas HBV/HCV/HIV-1 Control Kit, and linearity was evaluated across the anticipated measuring range (10...
February 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Anyu Zhou, An Xie, Tae Yun Kim, Hong Liu, Guangbin Shi, Gyeoung-Jin Kang, Ning Jiang, Man Liu, Euy-Myoung Jeong, Bum-Rak Choi, Samuel C Dudley
BACKGROUND: Downregulated sodium currents in heart failure (HF) has been linked to increased arrhythmic risk. Reduced expression of mRNA stabilizing protein ELAVL1/HuR may be responsible for the downregulation of sodium channel gene SCN5A mRNA. OBJECTIVE: To investigate whether HuR regulates SCN5A mRNA expression and whether manipulation of HuR benefits arrhythmia control in HF. METHODS: Quantitative real-time reverse-transcriptase PCR (qRT-PCR) were used to investigate the expression of SCN5A...
February 15, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Seung-Yul Lee, Jung-Sun Kim, Hyuck-Jun Yoon, Seung-Ho Hur, Sang-Gon Lee, Jin Won Kim, Young Joon Hong, Ki-Seok Kim, So-Yeon Choi, Dong-Ho Shin, Chung-Mo Nam, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
OBJECTIVES: This study sought to measure early strut coverage in patients receiving drug-eluting stents (DESs) and to explore the feasibility of short-term dual antiplatelet therapy (DAPT) based on the degree of early strut coverage. BACKGROUND: Data for early strut coverage in patients receiving new-generation DESs, and its implications for DAPT continuation were limited. METHODS: A randomized, multicenter trial was conducted in 894 patients treated with DESs...
February 9, 2018: JACC. Cardiovascular Imaging
Jonathan R Brody, Dan A Dixon
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with dismal patient outcomes. The underlying core genetic drivers of disease have been identified in human tumor specimens and described in genetically engineered mouse models. These genetic drivers of PDAC include KRAS signaling, TP53 mutations, and genetic loss of the SMAD4 tumor suppressor protein. Beyond the known mutational landscape of PDAC genomes, alternative disrupted targets that extend beyond conventional genetic mutations have been elusive and understudied in the context of PDAC cell therapeutic resistance and survival...
February 16, 2018: Wiley Interdisciplinary Reviews. RNA
Dong Gu Hur, Arwa Kurabi, Allen F Ryan
No abstract text is available yet for this article.
January 2018: Neural Regeneration Research
Dakeun Lee, Sang-Yong Son, Young-Bae Kim, Sang-Uk Han, Hoon Hur
BACKGROUND: Gastric signet ring cell carcinoma (SRC) has shown a favorable outcome in early stages but has a worse prognosis than non-SRC in advanced stages. However, the cause for this stage-dependent prognostic impact has not been determined. This study aimed to compare clinicopathologic features and recurrence patterns between gastric SRC and non-SRC in a cohort of Eastern patients. METHODS: This study reviewed the prospectively collected data of 764 patients undergoing curative resection for gastric cancer from 2005 to 2008...
February 15, 2018: Annals of Surgical Oncology
Ngoc Xuan Dat Mai, Duckshin Park, Juyeon Yoon, Jaehyun Hur
A series of hydrogen-based TiO2 photocatalysts were prepared by the simple entrapment of TiO2 nanoparticles in different hydrogel matrices using gelation processes. The hydrogels, namely, agarose, alginate, and chitosan, were used as matrices for TiO2 immobilization. Morphological differences were characterized for the three different hybrid gel photocatalysts. The rate of methylene blue (MB) photodegradation increased with increasing initial TiO2 dosage in all samples. The structural properties of the hydrogels significantly affected the diffusion of MB and altered the photocatalytic activities...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Kevin Hur, Varun Angajala, Dennis Maceri, Christian Hochstim
OBJECTIVE: To assess geographical sociodemographic differences in the pediatric esophageal foreign body population of Los Angeles. METHODS: We retrospectively reviewed the medical records of 128 consecutive pediatric patients at Children's Hospital Los Angeles (CHLA) from 2014 to 2017 with a diagnosis of a retained foreign body in the esophagus removed by rigid or flexible esophagoscopy. Sociodemographic information including zip code of residence was extracted and analyzed with Chi-square, Fisher's exact test, and multivariable logistic regression...
March 2018: International Journal of Pediatric Otorhinolaryngology
Jeonghyun Choi, Seunghoon Lee, Jinyoung Won, Yunho Jin, Yunkyung Hong, Tai-Young Hur, Joo-Heon Kim, Sang-Rae Lee, Yonggeun Hong
Autism spectrum disorder (ASD) is induced by complex hereditary and environmental factors. However, the mechanisms of ASD development are poorly understood. The purpose of this study was to identify standard indicators of this condition by comparing clinical, pathophysiological, and neurobehavioral features in an autism-like animal model. A total of 22 male Sprague-Dawley rats were randomly divided into control and 500 mg/kg propionic acid (PPA)-treated groups. Rats were subjected to behavioral tests, gene expression analyses, and histological analyses to detect pathophysiological and neurobehavioral alterations...
2018: PloS One
Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L Dawson, Ted M Dawson, Eun-Mi Hur, Byoung Dae Lee
BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing evidence suggesting a role of LRRK2 in membrane and vesicle trafficking, here we systemically screened Rab GTPases, core regulators of vesicular dynamics, as potential substrates of LRRK2 and investigated the functional consequence of such phosphorylation in cells and in vivo...
February 13, 2018: Molecular Neurodegeneration
Simona Retelletti Brogi, Sun-Yong Ha, Kwanwoo Kim, Morgane Derrien, Yun Kyung Lee, Jin Hur
Sea ice contains a large amount of dissolved organic matter (DOM), which can be released into the ocean once it melts. In this study, Arctic sea ice DOM was characterized for its optical (fluorescence) properties as well as the molecular sizes and composition via size exclusion chromatography and Fourier transformation ion cyclotron resonance mass spectrometry (FT-ICR MS). Ice cores were collected along with the underlying seawater samples in Cambridge Bay, an Arctic area experiencing seasonal ice formation...
February 1, 2018: Science of the Total Environment
L Qian, A-H Ji, W-J Zhang, N Zhao
OBJECTIVE: This study sought to explore HuR, Thrombotic Thrombocytopenic Purpura (TTP), and microRNA 133b (miR-133b) expression levels in non-small cell lung cancer (NSCLC) patients and assess the relationship of expression with disease prognosis. PATIENTS AND METHODS: One hundred and ten paraffin-embedded and 33 fresh flash-frozen NSCLC samples, together with matched tumor adjacent normal tissue controls, were collected from patients between January 2013 and July 2015 in Yidu Central Hospital of Weifang...
January 2018: European Review for Medical and Pharmacological Sciences
Nam Wook Hur, Hyeon Chang Kim, Linda Waite, Yoosik Youm
Objective: To investigate the buffering effects of social support as an effects modifier in the association between depression and inflammation in the elderly. Methods: We analyzed the Korean Social Life, Health, and Aging Project (KSHAP) for questionnaire, clinical, and laboratory data of 530 older adults living in a rural community. Multivariate regression models were used to investigate the association between depressive symptoms and C-reactive protein level (CRP), a marker of inflammation, at varying levels of social support...
January 2018: Psychiatry Investigation
Layla A Al-Kharashi, Falah H Al-Mohanna, Asma Tulbah, Abdelilah Aboussekhra
The activation of breast stromal fibroblasts is a crucial step toward tumor growth and spread. Therefore, it is extremely important to understand the molecular basis of this activation and determine the molecules and the mechanisms responsible for its sustainability. In the present report we have shown that the DNA methyl-transferase protein DNMT1 is critical for the activation of breast stromal fibroblasts as well as the persistence of their active status. Indeed, we have first revealed DNMT1 up-regulation in most cancer-associated fibroblasts relative to their corresponding adjacent normal fibroblasts...
January 5, 2018: Oncotarget
Tahir Maqbool, Jinwoo Cho, Jin Hur
Spectroscopic techniques were used to examine the subtle changes in soluble microbial products (SMP) of batch activated sludge bioreactors working at different salinities (i.e., 0%, 1%, 3%, and 5% NaCl). The changes in different fluorescent constituent were tracked by excitation-emission matrix combined with parallel factor analysis (EEM-PARAFAC), and the sequential production was further identified by two-dimensional correlation spectroscopy (2D-COS). Greater enrichment of tryptophan-like component and large-sized biopolymer were found in SMP for higher saline bioreactors, suggesting the SMP sources from bound extracellular polymeric substances and excreted intercellular constituents...
January 31, 2018: Bioresource Technology
Tala Bakheet, Edward Hitti, Maher Al-Saif, Walid N Moghrabi, Khalid S A Khabar
Adenylate-uridylate (AU)-rich elements (AREs) are sequence instability elements that are known to be located in the 3' untranslated regions (UTR) in thousands of human transcripts. AREs regulate the expression of many genes at the post-transcriptional level, and they are essential for many normal cellular functions. We conducted a transcriptome-wide screen for AREs and found that they are most abundant in introns, with up to 25% of introns containing AREs corresponding to 58% of human genes. Clustering studies of ARE size, complexity, and distribution revealed that, in introns, longer AREs with two or more overlapping repeats are more abundant than in the 3'UTR, and only introns can contain very long AREs with 6-14 overlapping AUUUA pentamers...
February 1, 2018: Biochimica et Biophysica Acta
Eun Young Jung, Sang Keun Jin, Sun Jin Hur
The effects of biopolymer encapsulation and sodium replacement combination technology on quality characteristics (i.e., bitter taste) and inhibition of sodium absorption from pork sausage in mice were evaluated. The sausages were divided into three different sodium replacement groups (none, 40%, and 50%) and three different biopolymer encapsulation groups (none, cellulose, and chitosan) in combination. In groups with 50% sodium replacement by KCl and MgCl2, T8 (chitosan encapsulation) showed the highest inhibition of the sodium absorption rate...
June 1, 2018: Food Chemistry
Quang Viet Ly, Long D Nghiem, Mark Sibag, Tahir Maqbool, Jin Hur
The relative ratios of chemical oxygen demand (COD) to nitrogen (N) in wastewater are known to have profound effects on the characteristics of soluble microbial products (SMP) from activated sludge. In this study, the changes in the SMP characteristics upon different COD/N ratios and the subsequent effects on ultrafiltration (UF) membrane fouling potentials were examined in sequencing batch reactors (SBR) using excitation emission matrix-parallel factor analysis (EEM-PARAFAC) and size exclusion chromatography (SEC)...
February 1, 2018: Water Research
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