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https://www.readbyqxmd.com/read/28644849/rapid-development-of-cyanobacterial-crust-in-the-field-for-combating-desertification
#1
Chan-Ho Park, Xin Rong Li, Yang Zhao, Rong Liang Jia, Jae-Seoun Hur
Desertification is currently a major concern, and vast regions have already been devastated in the arid zones of many countries. Combined application of cyanobacteria with soil fixing chemicals is a novel method of restoring desertified areas. Three cyanobacteria, Nostoc sp. Vaucher ex Bornet & Flahault, Phormidium sp. Kützing ex Gomont and Scytonema arcangeli Bornet ex Flahault were isolated and tested in this study. Tacki-SprayTM (TKS7), which consists of bio-polysaccharides and tackifiers, was used as a soil fixing agent...
2017: PloS One
https://www.readbyqxmd.com/read/28643487/proenkephalin-neutrophil-gelatinase-associated-lipocalin-and-estimated-glomerular-filtration-rates-in-patients-with-sepsis
#2
Hanah Kim, Mina Hur, Seungho Lee, Rossella Marino, Laura Magrini, Patrizia Cardelli, Joachim Struck, Andreas Bergmann, Oliver Hartmann, Salvatore Di Somma
BACKGROUND: Proenkephalin (PENK) has been suggested as a novel biomarker for kidney function. We investigated the diagnostic and prognostic utility of plasma PENK in comparison with neutrophil gelatinase-associated lipocalin (NGAL) and estimated glomerular filtration rates (eGFR) in septic patients. METHODS: A total of 167 septic patients were enrolled: 99 with sepsis, 37 with septic shock, and 31 with suspected sepsis. PENK and NGAL concentrations were measured and GFR was estimated by using the isotope dilution mass spectrometry traceable-Modification of Diet in Renal Disease (MDRD) Study and three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations: CKD-EPI(Cr), CDK-EPI(CysC), and CKD-EPI(Cr-CysC)...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28637868/decreased-mir26a-b-and-increased-hur-expression-post-transcriptionally-upregulates-erbb2-to-mediate-acquired-tamoxifen-resistance-in-er-breast-cancer-cells
#3
Sheng Tan, Keshuo Ding, Qing-Yun Chong, Junsong Zhao, Yuan Liu, Yunying Shao, Yuanyuan Zhang, Qing Yu, Zirui Xiong, Weijie Zhang, Min Zhang, Gaopeng Li, Xiaoni Li, Xiangjun Kong, Akhlaq Ahmad, Zhengsheng Wu, Qiang Wu, Xiaodong Zhao, Peter E Lobie, Tao Zhu
Tamoxifen-resistant ER-positive breast cancer is characterized by elevated ERBB2 expression. However, the underlying mechanisms responsible for the increased ERBB2 expression in the tamoxifen resistant (TAMR) cells remains poorly understood. Herein, we reported that the ERBB2 expression is regulated at the post-transcriptional level by miR26a/b and the RNA-binding protein HuR, both of which associate with the 3'UTR of the ERBB2 transcripts. We demonstrated that miR26a/b inhibits the translation of ERBB2 mRNA, while HuR enhances the stability of the ERBB2 mRNA...
June 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28634131/cost-effectiveness-of-pre-versus-post-liver-transplant-hepatitis-c-treatment-with-direct-acting-antivirals
#4
Sumeyye Samur, Brian Kues, Turgay Ayer, Mark S Roberts, Fasiha Kanwal, Chin Hur, Drew Michael S Donnell, Raymond T Chung, Jagpreet Chhatwal
BACKGROUND & AIMS: Oral direct-acting antivirals (DAAs) for hepatitis C virus (HCV) treatment offer new hope to both pre- and post-liver transplant (LT) patients. However, whether to treat HCV patients pre- versus post-LT is not clear, as treatment can improve liver function but could reduce the chance of receiving a LT while on the waiting list. Our objective was to evaluate the cost-effectiveness of pre-LT versus post-LT HCV treatment with oral DAAs in decompensated cirrhotic patients on the LT waiting list...
June 17, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28632487/prospective-randomized-comparison-of-idarubicin-and-high-dose-daunorubicin-in-induction-chemotherapy-for-newly-diagnosed-acute-myeloid-leukemia
#5
Je-Hwan Lee, Hawk Kim, Young-Don Joo, Won-Sik Lee, Sung Hwa Bae, Dae Young Zang, Jihyun Kwon, Min Kyoung Kim, Junglim Lee, Gyeong Won Lee, Jung-Hee Lee, Yunsuk Choi, Dae-Young Kim, Eun-Hye Hur, Sung-Nam Lim, Sang-Min Lee, Hun Mo Ryoo, Hyo Jung Kim, Myung Soo Hyun, Kyoo-Hyung Lee
Purpose We compared two induction regimens, idarubicin (12 mg/m(2)/d for 3 days) versus high-dose daunorubicin (90 mg/m(2)/d for 3 days), in young adults with newly diagnosed acute myeloid leukemia (AML). Patients and Methods A total of 299 patients (149 randomly assigned to cytarabine plus idarubicin [AI] and 150 assigned to cytarabine plus high-dose daunorubicin [AD]) were analyzed. All patients received cytarabine (200 mg/m(2)/d for 7 days). Results Complete remission (CR) was induced in 232 patients (77...
June 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28630277/t-cell-intracellular-antigens-and-hu-antigen-r-antagonistically-modulate-mitochondrial-activity-and-dynamics-by-regulating-optic-atrophy-1-gene-expression
#6
Isabel Carrascoso, José Alcalde, Carmen Sánchez-Jiménez, Paloma González-Sánchez, José M Izquierdo
Mitochondria undergo frequent morphological changes to control their function. We show here that T-cell intracellular antigens (TIA1b/TIARb) and Hu antigen R (HuR) have antagonistic roles in mitochondrial function by modulating the expression of mitochondrial shaping proteins. Expression of TIA1b/TIARb alters the mitochondrial dynamic network by enhancing fission and clustering, which is accompanied by a decrease in respiration. By contrast, HuR expression promotes fusion and cristae remodeling and increases respiratory activity...
June 19, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28628824/structure-activity-relationship-investigation-for-benzonaphthyridinone-derivatives-as-novel-potent-bruton-s-tyrosine-kinase-btk-irreversible-inhibitors
#7
Beilei Wang, Yuanxin Deng, Yongfei Chen, Kailin Yu, Aoli Wang, Qianmao Liang, Wei Wang, Cheng Chen, Hong Wu, Chen Hu, Weili Miao, Wooyoung Hur, Wenchao Wang, Zhenquan Hu, Ellen L Weisberg, Jinhua Wang, Tao Ren, Yinsheng Wang, Nathanael S Gray, Qingsong Liu, Jing Liu
Through a structure-based drug design approach, a tricyclic benzonaphthyridinone pharmacophore was used as a starting point for carrying out detailed medicinal structure-activity relationhip (SAR) studies geared toward characterization of a panel of proposed BTK inhibitors, including 6 (QL-X-138), 7 (BMX-IN-1) and 8 (QL47). These studies led to the discovery of the novel potent irreversible BTK inhibitor, compound 18 (CHMFL-BTK-11). Kinetic analysis of compound 18 revealed an irreversible binding efficacy (kinact/Ki) of 0...
June 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28624995/how-does-it-feel-to-be-a-pathology-resident-results-of-a-survey-on-experiences-and-job-satisfaction-during-pathology-residency
#8
Burcin Pehlivanoglu, Hur Hassoy, Catarina Calle, Amelie Dendooven, ILKe Nalbantoglu, Lidiya Reshchikova, Gulen Gul, Basak Doganavsargil
Residents' career choices and professional motivation can be affected from perception of their role and recognition within a medical team as well as their educational and workplace experiences. To evaluate pathology trainees' perceptions of their pathology residency, we conducted a 42-item survey via a web-based link questioning respondents' personal and institutional background, workplace, training conditions, and job satisfaction level. For the 208 residents from different European countries who responded, personal expectations in terms of quality of life (53%) and scientific excitement (52%) were the most common reasons why they chose and enjoy pathology...
June 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28622053/importance-of-sandy-bottoms-in-coral-reefs-to-the-oscillation-of-daily-rhythms-in-the-tropical-wrasse-halichoeres-trimaculatus
#9
Hitomi Ito-Takeuchi, Kai Takahashi, Selma Bouchekioua, Chihiro Yamauchi, Yuki Takeuchi, Sung-Pyo Hur, Young-Don Lee, Akihiro Takemura
Most wrasse species swim during the day and bury themselves in the sandy bottoms of shallow reefs at night. This study aimed to evaluate the importance of sandy bottoms to the day-active/night-inactive rhythmicity of the tropical wrasse Halichoeres trimaculatus. Actogram analysis revealed that fish were active during the photophase and inactive during the scotophase in aquariums with both sandy and bare bottoms. When fish were kept in aquariums with bare bottoms, rhythmicity was maintained under constant dark conditions (DD) but became obscured under constant light conditions (LL), suggesting that a day-active/night-inactive rhythmicity is regulated by the circadian system...
June 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28620016/correction-for-doller-et-al-tandem-phosphorylation-of-serines-221-and-318-by-protein-kinase-c%C3%AE-coordinates-mrna-binding-and-nucleocytoplasmic-shuttling-of-hur
#10
Anke Doller, Kai Schlepckow, Harald Schwalbe, Josef Pfeilschifter, Wolfgang Eberhardt
No abstract text is available yet for this article.
July 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28618825/spectral-equalization-in-binaural-signals-represented-by-order-truncated-spherical-harmonics
#11
Zamir Ben-Hur, Fabian Brinkmann, Jonathan Sheaffer, Stefan Weinzierl, Boaz Rafaely
The synthesis of binaural signals from spherical microphone array recordings has been recently proposed. The limited spatial resolution of the reproduced signal due to order-limited reproduction has been previously investigated perceptually, showing spatial perception ramifications, such as poor source localization and limited externalization. Furthermore, this spatial order limitation also has a detrimental effect on the frequency content of the signal and its perceived timbre, due to the rapid roll-off at high frequencies...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28618772/efficacy-and-safety-of-pitavastatins-in-patients-with-acute-myocardial-infarction-livalo-in-acute-myocardial-infarction-study-lamis-ii
#12
Young Joon Hong, Myung Ho Jeong, Jang Ho Bae, Seok Kyu Oh, Seung Woon Rha, Seung Ho Hur, Sung Yun Lee, Sang Wook Kim, Kwang Soo Cha, In Ho Chae, Tae Hoon Ahn, Kee Sik Kim
Background/Aims: We evaluated the efficacy and safety and influence on glucose tolerance by different doses of pitavastatins in acute myocardial infarction (AMI) patients. Methods: Consecutive 1,101 AMI patients who were enrolled in Livalo in Acute Myocardial Infarction Study (LAMIS)-II were randomly assigned to receive either 2 mg of pitavastatin or 4 mg of pitavastatin orally per day. Primary efficacy endpoint was composite of cardiac death, nonfatal myocardial infarction, target-lesion revascularization, and hospitalization for unstable angina, heart failure or arrhythmic events at 12-month...
June 16, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28614559/suicide-rates-and-the-declining-psychiatric-hospital-bed-capacity-in-the-united-states
#13
Robert D Gibbons, Kwan Hur, J John Mann
No abstract text is available yet for this article.
June 14, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28612661/is-there-an-association-between-mismatch-negativity-and-cortical-thickness-in-schizophrenia-patients
#14
Jiyoon J Seol, Minah Kim, Kwang Hyuk Lee, Ji-Won Hur, Kang Ik K Cho, Tae Young Lee, Chun Kee Chung, Jun Soo Kwon
INTRODUCTION: Mismatch negativity (MMN) is thought to reflect preattentive, automatic auditory processing. Reduced MMN amplitude is among the most robust findings in schizophrenia research. MMN generators have been shown to be located in the temporal and frontal cortices, which are key areas in the pathophysiology of schizophrenia. This study investigated whether frontotemporal cortical thickness was associated with reduced MMN current source density (CSD) strength in patients with schizophrenia...
June 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/28611824/posttranscriptional-regulation-controls-calretinin-expression-in-malignant-pleural-mesothelioma
#15
Jelena Kresoja-Rakic, Merve Sulemani, Michaela B Kirschner, Manuel Ronner, Glen Reid, Steven Kao, Beat Schwaller, Walter Weder, Rolf A Stahel, Emanuela Felley-Bosco
Calretinin (CALB2) is a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM). We previously reported that calretinin expression is regulated at the mRNA level. The presence of a medium-sized (573 nucleotide) 3' untranslated region (3'UTR) predicted to contain binding sites for miR-30a/b/c/d/e and miR-9 as well as an adenine/uridine-rich element (ARE) in all three transcripts arising from the CALB2 gene, suggests that calretinin expression is regulated via posttranscriptional mechanisms. Our aim was to investigate the role of the CALB2-3'UTR in the posttranscriptional regulation of calretinin expression in MPM...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28609205/diagnostic-performance-of-gadoxetic-acid-enhanced-liver-mr-imaging-versus-multidetector-ct-in-the-detection-of-dysplastic-nodules-and-early-hepatocellular-carcinoma
#16
Bo Ram Kim, Jeong Min Lee, Dong Ho Lee, Jeong Hee Yoon, Bo Yun Hur, Kyung Suk Suh, Nam-Joon Yi, Kyung Boon Lee, Joon Koo Han
Purpose To compare the diagnostic performance of gadoxetic acid-enhanced liver magnetic resonance (MR) imaging with that of contrast material-enhanced multidetector computed tomography (CT) in the detection of borderline hepatocellular nodules in patients with liver cirrhosis and to determine the Liver Imaging Reporting and Data System (LI-RADS) categories of these detected nodules. Materials and Methods The institutional review board approved this retrospective study and waived the informed consent requirement...
June 13, 2017: Radiology
https://www.readbyqxmd.com/read/28605144/musculoskeletal-disease-in-mda5-related-type-i-interferonopathy-a-mendelian-mimic-of-jaccoud-s-arthropathy
#17
Luciana Martins de Carvalho, Gonza Ngoumou, Ji Woo Park, Nadja Ehmke, Nikolaus Deigendesch, Naoki Kitabayashi, Isabelle Melki, Flávio Falcäo L Souza, Andreas Tzschach, Marcello H Nogueira-Barbosa, Virgínia Ferriani, Paulo Louzada-Junior, Wilson Marques Junior, Charles M Lourenço, Prof Denise Horn, Tilmann Kallinich, Werner Stenzel, Sun Hur, Gillian I Rice, Yanick J Crow
Objectives To define the molecular basis of a multisystem phenotype with progressive musculoskeletal disease of the hands and feet including camptodactyly, subluxation and tendon rupture reminiscent of Jaccoud's arthropathy. Methods We ascertained two families segregating an autosomal dominant phenotype encompassing musculoskeletal disease and variable additional features including psoriasis, dental abnormalities, cardiac valve involvement, glaucoma and basal ganglia calcification. We measured the expression of interferon-stimulated genes in peripheral blood and skin, and undertook targeted Sanger sequencing of the IFIH1 gene encoding the cytosolic double-stranded RNA sensor MDA5...
June 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28604745/the-proto-oncoprotein-kr-pok-represses-transcriptional-activation-of-cdkn1a-by-miz-1-through-competitive-binding
#18
K M Lee, W I Choi, D I Koh, Y J Kim, B N Jeon, J H Yoon, C E Lee, S H Kim, J Oh, M W Hur
This corrects the article DOI: 10.1038/onc.2011.331.
June 12, 2017: Oncogene
https://www.readbyqxmd.com/read/28604628/privacy-preserving-electrocardiogram-monitoring-for-intelligent-arrhythmia-detection
#19
Junggab Son, Juyoung Park, Heekuck Oh, Md Zakirul Alam Bhuiyan, Junbeom Hur, Kyungtae Kang
Long-term electrocardiogram (ECG) monitoring, as a representative application of cyber-physical systems, facilitates the early detection of arrhythmia. A considerable number of previous studies has explored monitoring techniques and the automated analysis of sensing data. However, ensuring patient privacy or confidentiality has not been a primary concern in ECG monitoring. First, we propose an intelligent heart monitoring system, which involves a patient-worn ECG sensor (e.g., a smartphone) and a remote monitoring station, as well as a decision support server that interconnects these components...
June 12, 2017: Sensors
https://www.readbyqxmd.com/read/28602994/fish-collagen-peptide-inhibits-the-adipogenic-differentiation-of-preadipocytes-and-ameliorates-obesity-in-high-fat-diet-fed-mice
#20
Eun Ji Lee, Jinwoo Hur, Sun Ah Ham, Yeonji Jo, SangYoon Lee, Mi-Jung Choi, Han Geuk Seo
Bioactivities of fish collagen peptide are now being elucidated in diverse biological systems. Here, we investigated the effect of fish collagen peptide on the adipogenic differentiation of 3T3-L1 preadipocytes and in obese mice fed a high fat diet (HFD). Subcritical water-hydrolyzed fish collagen peptide (SWFCP) significantly inhibited lipid accumulation during the differentiation of 3T3-L1 preadipocytes, which was accompanied by decreased expression of CCAAT-enhancer-binding protein-α (C/EBP-α), peroxisome proliferator-activated receptor-γ (PPAR-γ), and adipocyte protein 2 (aP2) genes, key regulators of differentiation and maintenance of adipocytes...
June 9, 2017: International Journal of Biological Macromolecules
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