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Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Yoon-Mi Hur, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Syuichi Ooki, Vilhelmina Ullemar, Catarina Almqvist, Patrik K E Magnusson, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Tessa L Cutler, John L Hopper, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F Krueger, Matt McGue, Shandell Pahlen, S Alexandra Burt, Kelly L Klump, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveld, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Kauko Heikkilä, Kirsi H Pietiläinen, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire M A Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Jina Kim, Jooyeon Lee, Sooji Lee, Joohon Sung, Ruth J F Loos, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries...
April 12, 2018: Early Human Development
Gayeon Won, Seong Kug Eo, Sang-Youel Park, Jin Hur, John Hwa Lee
We previously genetically engineered a Salmonella Typhi bacterial ghost (STG) as a novel inactivated vaccine candidate against typhoid fever. The underlying mechanism employed by the ghost to stimulate the adaptive immune response remains to be investigated. In this study, we aimed to evaluate the immunostimulatory effect of STG on mouse bone marrow-derived dendritic cells (BMDCs) and its activation of the adaptive immune response in vitro . Immature BMDCs were stimulated with STG, which efficiently stimulated maturation events in BMDCs, as indicated by up-regulated expression of CD40, CD80, and MHC-II molecules on CD11+ BMDCs...
April 12, 2018: Journal of Veterinary Science
Min Ju Kim, Bo Yun Hur, Eun Sun Lee, Boram Park, Jungnam Joo, Min Jung Kim, Sung Chan Park, Ji Yeon Baek, Hee Jin Chang, Dae Yong Kim, Jae Hwan Oh
PURPOSE: To investigate the predictive factors for lateral pelvic lymph node (LPLN) metastasis in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy (CRT). MATERIALS AND METHODS: Fifty-seven patients with locally advanced rectal cancer and LPLNs larger than 5 mm underwent LPLN dissection (LPLD) after preoperative CRT. The MRI findings, including the apparent diffusion coefficient value and LPLN size reduction rate before/after CRT; clinical factors; and pathologic results were evaluated to identify the predictive factors associated with LPLN metastasis...
2018: PloS One
Min Chul Kim, Myung Ho Jeong, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Tae Hoon Ahn, Ki Bae Seung, Dong-Ju Choi, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyoung-Kook Hwang, Shung Chull Chae, Seung Ho Hur, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae
BACKGROUND: There is little information regarding comparison of ticagrelor and prasugrel in patients with ST-segment elevation myocardial infarction (STEMI). We sought to compare clinical outcomes between ticagrelor and prasugrel in STEMI.Methods and Results:A total of 1,440 patients with STEMI who underwent successful primary percutaneous coronary intervention were analyzed; the data were obtained from the Korea Acute Myocardial Infarction Registry-National Institutes of Health. Of the patients, 963 received ticagrelor, and 477 received prasugrel...
April 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Yoon-Mi Hur, Hana Yu, Hee-Jeong Jin, Siwoo Lee
In traditional East Asian medicine, cold-heat patterns have been widely used in the diagnosis and treatment of patients suffering from various diseases. The present study aimed to estimate the heritability of cold-heat patterns. Trained interviewers administered a cold-heat pattern questionnaire to 1,753 twins (mean age = 19.1 ± 3.1 years) recruited throughout South Korea. Correlations for the cold pattern (CP) were 0.42 (95% CI [0.28, 0.54]) for monozygotic (MZ) males, 0.16 (95% CI [-0.08, 0.39]) for dizygotic (DZ) males, 0...
April 12, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
Jun Hee Lee, Chul Won Yun, Jin Hur, Sang Hun Lee
Mesenchymal stem cells (MSCs) are a source for cell-based therapy. Although MSCs have the potential for tissue regeneration, their therapeutic efficacy is restricted by the uremic toxin, p -cresol, in chronic kidney disease (CKD). To address this issue, we investigated the effect of fucoidan, a marine sulfated polysaccharide, on cellular senescence in MSCs. After p -cresol exposure, MSC senescence was induced, as indicated by an increase in cell size and a decrease in proliferation capacity. Treatment of senescent MSCs with fucoidan significantly reversed this cellular senescence via regulation of SMP30 and p21, and increased proliferation through the regulation of cell cycle-associated proteins (CDK2, CDK4, cyclin D1, and cyclin E)...
April 6, 2018: Marine Drugs
Ji Yeong An, Jae Seok Min, Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang Uk Han, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Ji Yeon Park, Young Woo Kim, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu
Purpose: We investigated complications after laparoscopic sentinel basin dissection (SBD) for patients with gastric cancer who were enrolled in a quality control study, prior to the phase III trial of sentinel lymph node navigation surgery (SNNS). Materials and Methods: We analyzed prospective data from a Korean multicenter prerequisite quality control trial of laparoscopic SBD for gastric cancer and assessed procedure-related and surgical complications. All complications were classified according to the Clavien-Dindo Classification (CDC) system and were compared with the results of the previously published SNNS trial...
March 2018: Journal of Gastric Cancer
Sakun Duwal, Young-Jay Ryu, Minseob Kim, Choong-Shik Yoo, Sora Bang, Kyungtae Kim, Nam Hwi Hur
Hydrazinium azide (HA) has been investigated at high pressures to 68 GPa using confocal micro-Raman spectroscopy and synchrotron powder x-ray diffraction. The results show that HA undergoes structural phase transitions from solid HA-I to HA-II at 13 GPa, associated with the strengthening of hydrogen bonding, and then to N8 at 40 GPa. The transformation of HA to recently predicted N8 (N≡N+ -N- -N=N-- N-+ N≡N) is evident by the emergence of new peaks at 2384 cm-1 , 1665 cm-1 , and 1165 cm-1 , arising from the terminal N≡N stretching, the central N=N stretching, and the N-N stretching, respectively...
April 7, 2018: Journal of Chemical Physics
Justine Hur, Véronique Mateo, Nicolas Amalric, Mégane Babiak, Gilbert Béréziat, Claire Kanony-Truc, Thierry Clerc, Régis Blaise, Isabelle Limon
Cerebral amyloid angiopathy (CAA) is a major contributor to Alzheimer's disease (AD) pathogenesis. Like AD, CAA is often accompanied by marked inflammation, aggravating associated vasculopathies. No evidence-based prevention or treatment strategies are available. Here, we evaluate the possible beneficial effect of a diet enriched with docosahexaenoic acid (DHA), which is known to attenuate inflammation in CAA. Tg2576 mice, a transgenic model of AD/CAA, were fed a DHA-enriched diet starting at 2 mo of age and ending at 10, 14, or 18 mo of age...
April 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Jaechul Yoon, Dohern Kym, Jun Hur, Youngmin Kim, Hyeong-Tae Yang, Haejun Yim, Yong Suk Cho, Wook Chun
OBJECTIVES: We evaluated the ability of new sepsis (S3) criteria (compared with previous definitions of sepsis [S1] and burn sepsis criteria) to accurately determine the mortality in severe burns patients with sepsis. DESIGN: This was retrospective cohort study. SETTING: The Burn ICU of Burn Center, Hangang Sacred Heart Hospital, Hallym University, Seoul, Korea. PATIENTS: A total of 1,185 adult patients (mean age, 49...
April 3, 2018: Critical Care Medicine
Georgia Levidou, Ioly Kotta-Loizou, Jason Tasoulas, Thomas Papadopoulos, Stamatios Theocharis
Background: Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis. This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas. Methods: The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented and summarised. Results: HuR is expressed in the majority of the examined samples, showing higher cytoplasmic levels in malignant or premalignant cases...
2018: Disease Markers
Alexander R Gawronski, Michael Uhl, Yajia Zhang, Yen-Yi Lin, Yashar S Niknafs, Varune R Ramnarine, Rohit Malik, Felix Feng, Arul M Chinnaiyan, Colin C Collins, S Cenk Sahinalp, Rolf Backofen
Motivation: Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that do not get translated into proteins. Often these transcripts are processed (spliced, capped, polyadenylated) and some are known to have important biological functions. However, most lncRNAs have unknown or poorly understood functions. Nevertheless, because of their potential role in cancer, lncRNAs are receiving a lot of attention, and the need for computational tools to predict their possible mechanisms of action is more than ever...
April 3, 2018: Bioinformatics
Gil Soo Kim, Wonmin Ko, Jong Won Kim, Min-Hye Jeong, Sung-Kyun Ko, Jae-Seoun Hur, Hyuncheol Oh, Jae-Hyuk Jang, Jong Seog Ahn
Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher's method. Compound 2 inhibited nitric oxide (NO) production with IC50 values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)...
April 4, 2018: Journal of Natural Products
Pan Ki Kim, Yoo Jin Hong, Hajime Sakuma, Ashish Chawla, Jeffrey Kihyun Park, Chul Hwan Park, Donghyun Hong, Kyunghwa Han, Ji Yeon Lee, Jin Hur, Hye-Jeong Lee, Young Jin Kim, Young Joo Suh, Byoung Wook Choi
Purpose To evaluate the effect of changes in hematocrit level on myocardial extracellular volume (ECV) fraction, as quantified with cardiac magnetic resonance (MR) imaging in an animal model. Materials and Methods Thirteen adult male Sprague-Dawley rats underwent cardiac MR imaging before and after induction of anemia. MR imaging procedures, including unenhanced and contrast material-enhanced T1 mapping, were performed by using a saturation recovery Look-Locker sequence with a 9.4-T unit. An optimized T1 mapping sequence was established in the phantom study...
April 3, 2018: Radiology
Hee Won Moon, Mikyoung Park, Mina Hur, Hanah Kim, Won Hyeok Choe, Yeo Min Yun
BACKGROUND: Liver biopsies have been partially replaced by noninvasive methods for assessing liver fibrosis. We explored the usefulness of four novel biomarkers, enhanced liver fibrosis (ELF), glycosylation isomer of Mac-2 binding protein (M2BPGi), galectin-3, and soluble suppression of tumorigenicity 2 (sST2), in association with liver fibrosis. METHODS: ELF, M2BPGi, galectin-3, and sST2 were assayed in 173 patients with chronic liver diseases. The results were analyzed according to fibrosis grade (F0/1, F2, and F3/4) by transient elastography (TE)...
July 2018: Annals of Laboratory Medicine
Sun Young Cho, Mina Hur
No abstract text is available yet for this article.
July 2018: Annals of Laboratory Medicine
Michel Fruchart, Seung-Yeol Jeon, Kahyun Hur, Vadim Cheianov, Ulrich Wiesner, Vincenzo Vitelli
Soft materials can self-assemble into highly structured phases that replicate at the mesoscopic scale the symmetry of atomic crystals. As such, they offer an unparalleled platform to design mesostructured materials for light and sound. Here, we present a bottom-up approach based on self-assembly to engineer 3D photonic and phononic crystals with topologically protected Weyl points. In addition to angular and frequency selectivity of their bulk optical response, Weyl materials are endowed with topological surface states, which allow for the existence of one-way channels, even in the presence of time-reversal invariance...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ahram Yi, Chang-Hoon Lee, Hee-Won Moon, Hanah Kim, Mina Hur, Yeo-Min Yun
OBJECTIVES: The diagnostic tests for autoimmune disease include screening for autoantibodies for nuclear antigens (ANA) and antibodies against extractable nuclear antigens (ENA). Using the line immunoassay (LIA) method, various kinds of ENA antibodies can be detected simultaneously. We evaluated the performance of the newly launched LIA-ANA-Profile-17S (Shenzhen YHLO Biotech, Shenzhen, China) as compared to a conventional LIA kit. METHODS: Residual samples were collected from 200 patients who had been tested for ANA using indirect immunofluorescence...
March 30, 2018: Clinical Biochemistry
Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M A Rouschop, John Hancock, Ian Wilson, Michael Ladomery
BACKGROUND: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes using the prostate cancer cell line PC3 as a model. Secondly, the effect of hypoxia on the expression of several regulators of splicing was examined. METHODS: PC3 cells were grown in 1% oxygen in a hypoxic chamber for 48 h, RNA extracted and sent for high throughput PCR analysis at the RNomics platform at the University of Sherbrooke, Canada...
April 2, 2018: BMC Cancer
Eugenie Choe, Tae Young Lee, Minah Kim, Ji-Won Hur, Youngwoo Bryan Yoon, Kang-Ik K Cho, Jun Soo Kwon
INTRODUCTION: It has been suggested that the mentalizing network and the mirror neuron system network support important social cognitive processes that are impaired in schizophrenia. However, the integrity and interaction of these two networks have not been sufficiently studied, and their effects on social cognition in schizophrenia remain unclear. METHODS: Our study included 26 first-episode psychosis (FEP) patients and 26 healthy controls. We utilized resting-state functional connectivity to examine the a priori-defined mirror neuron system network and the mentalizing network and to assess the within- and between-network connectivities of the networks in FEP patients...
March 26, 2018: Schizophrenia Research
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