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anesthesia and cancer

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https://www.readbyqxmd.com/read/29034255/perioperative-management-of-elderly-patients-with-gastrointestinal-malignancies-the-contribution-of-anesthesia
#1
REVIEW
Rudolf Mörgeli, Kathrin Scholtz, Johannes Kurth, Sascha Treskatsch, Bruno Neuner, Susanne Koch, Lutz Kaufner, Claudia Spies
INTRODUCTION: Elderly patients suffering from gastrointestinal malignancies are particularly prone to perioperative complications. Elderly patients often present with reduced physiological reserves, and comorbidities can limit treatment options and promote complications. Surgeons and anesthesiologists must be aware of strategies required to deal with this vulnerable subgroup. METHODS: We provide a brief review of current and emerging perioperative strategies for the treatment of elderly patients with gastrointestinal malignancies and frequent comorbidities...
August 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29033716/transdermal-fentanyl-as-an-adjuvant-to-paravertebral-block-for-pain-control-after-breast-cancer-surgery-a-randomized-double-blind-controlled-trial
#2
Ahmed H Bakeer, Nasr M Abdallah
OBJECTIVE: The aim of this study is to investigate the effect of transdermal fentanyl (TDF) as an adjuvant to paravertebral block (PVB) for pain control after breast cancer surgery. PATIENTS AND METHODS: This randomized, double-blind trial included fifty females with breast cancer scheduled for surgery. They were randomly allocated into one of two equal groups. The TDF group used transdermal fentanyl patches (TFPs) 25 μg/h applied 10 h preoperative then PVB with 20 mL of bupivacaine 0...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28989150/-parecoxib-suppresses-the-increase-of-neutrophil-to-lymphocyte-ratio-after-the-modified-radical-mastectomy
#3
Yunli Li, Lei Zhou, Xiaoxiao Li, Gong Chen, Kaiming Duan, Boni Ding, Wen Ouyang
To observe the effect of parecoxib on neutrophil-to-lymphocyte ratio (NLR)after the modified radical mastectomy, and to explore its potential mechanisms for inhibition of perioperative inflammation.
 Methods: A total of 40 breast cancer patients undergone the modified radical mastectomy were randomly divided into a parecoxib group (n=20) and a control group (n=20). The parecoxib group received intravenous parecoxib (40 mg, 5 mL) during general anesthesia induction, post-operative day 1 and day 2; the control group received intravenous normal saline (5 mL) at the corresponding time points...
September 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28982906/survival-analysis-of-patients-with-breast-cancer-undergoing-a-modified-radical-mastectomy-with-or-without-a-thoracic-paravertebral-block-a-5-year-follow-up-of-a-randomized-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Manoj Kumar Karmakar, Winnie Samy, Anna Lee, Jia Wei Li, Wing Cheong Chan, Phoon Ping Chen, Ban C H Tsui
AIM: This 5-year prospective follow-up of women randomized to general anesthesia (GA) with or without a thoracic paravertebral block (TPVB) examined the risk of local recurrence, metastasis and mortality after breast cancer surgery. PATIENTS AND METHODS: A total of 180 patients undergoing modified radical mastectomy were randomized to one of three study groups: standardized GA only; GA with a single-injection TPVB (s-TPVB) and placebo paravertebral infusion after surgery for 72-h; and GA plus with continuous TPVB (c-TPVB) for 72-h postoperatively...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28977978/the-effects-of-intra-and-post-operative-anaesthesia-and-analgesia-choice-on-outcome-after-gastric-cancer-resection-a-retrospective-study
#5
Yu Wang, Liping Wang, Hong Chen, Yang Xu, Xiaoyu Zheng, Guonian Wang
BACKGROUND: Epidural use can provide a better short-term outcome and protect patients from the postoperative development of tumour recurrence and metastases. In this study, we sought to assess the effects of intra- and postoperative anaesthesia and analgesia choice on outcome after gastric cancer resection, searched for evidence of interaction between intra-and postoperative epidural use and outcomes of gastric cancer patients. METHODS: Four thousand two hundred and eighteen cases of gastric cancer were identified from the Records of Hospital Patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28961561/general-anesthesia-imposes-negative-effects-on-heart-rate-and-blood-pressure-regulation-in-patients-with-a-history-of-head-and-neck-radiation-therapy
#6
Gang Zheng, Wenli Dong, Carol M Lewis
BACKGROUND: Head and neck radiation therapy (HNRT) impairs baroreflex sensitivity, and it may potentiate the effects of anesthetics on heart rate (HR) and blood pressure (BP) regulation. Currently, the impacts of HNRT on HR and BP under anesthesia remain unclear. METHODS: In this study, 472 patients with primary oral cavity or oropharyngeal cancer at all stages were examined. Half of the patients underwent HNRT plus surgery. The other half underwent surgery only and was matched with the treatment patients according to age, sex, and body mass index at a 1:1 ratio...
September 28, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28959132/thoracic-esophagus-cancer-revealing-a-tracheal-diverticulum
#7
Takuki Yagyu, Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Shuichi Takano, Tomohiro Osaki, Yoshiyuki Fujiwara
Tracheal diverticulum is rarely encountered in a clinical setting since almost all patients are asymptomatic. However, its presence may become a problem during esophageal cancer operations in terms of anesthesia and lymph node dissection of superior mediastinum lymphadenectomy. A 70-year-old man with esophageal cancer was referred to our hospital. During thoracoscopic subtotal esophagectomy, we found a cystic lesion connected to the right posterior wall of the trachea. We evaluated the preoperative computed tomography scan during surgery and made a diagnosis of tracheal diverticulum because of the presence of paratracheal air cysts, which had not been noticed preoperatively...
September 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28953631/thoracic-paravertebral-regional-anesthesia-for-pain-relief-in-patients-with-breast-cancer-surgery
#8
RANDOMIZED CONTROLLED TRIAL
Lian-Jin Jin, Li-Yong Wen, Yan-Li Zhang, Gang Li, Ping Sun, Xuan Zhou
BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic paravertebral regional anesthesia (TPVBRA) in patients with breast cancer surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were randomly divided into an intervention group and a control group; each group contained 36 subjects. Both groups received TPVBRA with 20 mL 0.25% bupivacaine. In addition, subjects in the intervention group also received an additional 1 μg/kg dexmedetomidine...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28953508/impact-of-regional-anesthesia-on-recurrence-metastasis-and-immune-response-in-breast-cancer-surgery-a-systematic-review-of-the-literature
#9
Oscar Pérez-González, Luis F Cuéllar-Guzmán, José Soliz, Juan P Cata
BACKGROUND AND OBJECTIVES: The perioperative period is critical in the long-term prognosis of breast cancer patients. The use of regional anesthesia, such as paravertebral block (PVB), could be associated with improvements in long-term survival after breast cancer surgery by modulating the inflammatory and immune response associated with the surgical trauma, reducing opioid and general anesthetic consumption, and promoting cancer cells death by a direct effect of local anesthetics. METHODS: A systematic literature search was conducted for studies of patients who received PVB for breast cancer surgery...
September 27, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28953124/laser-excisional-treatment-for-vaginal-intraepithelial-neoplasia-to-exclude-invasion-what-is-the-risk-of-complications
#10
Francesco Sopracordevole, Lorenzo Moriconi, Jacopo Di Giuseppe, Lara Alessandrini, Elvia Del Piero, Giorgio Giorda, Monica Buttignol, Giovanni De Piero, Vincenzo Canzonieri, Andrea Ciavattini
OBJECTIVE: We undertook a retrospective analysis of the incidence of complications of carbon dioxide (CO2) laser excision for high-grade vaginal intraepithelial neoplasia (HG-VaIN). MATERIALS AND METHODS: Retrospective large case series on 128 CO2 laser excisions for HG-VaIN in 106 women treated at the Department of Gynecologic Oncology, Oncologic Referral Center, Aviano, Italy. These procedures were performed under local anesthesia with a 20-W continuous laser beam focused to a 0...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28951521/isoflurane-promotes-glucose-metabolism-through-upregulation-of-mir-21-and-suppresses-mitochondrial-oxidative-phosphorylation-of-ovarian-cancer-cells
#11
Nai-Liang Guo, Jing-Hua Tan, Jing-Ping Wu, Ying-Hua Xu
Ovarian cancer is one of the most lethal gynecologic malignancies in women. Isoflurane is one of volatile anesthetics used extensively for inhalational anesthesia and gynaecological surgery. However, the effects of isoflurane on ovarian cancer have not been fully elucidated. It is wildly studied that one of the biochemical fingerprints of cancer cells is the altered energy metabolism which is characterized by preferential dependence on glycolysis for energy production in an oxygen-independent manner. In this study, we explored the roles of isoflurane in the regulation of cellular metabolism of ovarian cancer cells...
September 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28951319/recent-advances-in-nanocarrier-loaded-gels-which-drug-delivery-technologies-against-which-diseases
#12
REVIEW
Marion Pitorre, Henri Gondé, Clotilde Haury, Marwa Messous, Jérémie Poilane, David Boudaud, Erdem Kanber, Glenn Alexis Rossemond Ndombina, Jean-Pierre Benoit, Guillaume Bastiat
The combination of pharmaceutical technologies can be a wise choice for developing innovative therapeutic strategies. The association of nanocarriers and gels provides new therapeutic possibilities due to the combined properties of the two technologies. Gels support the nanocarriers, localize their administration to the target tissue, and sustain their release. In addition to the properties afforded by the gel, nanocarriers can provide additional drug sustained release or different pharmacokinetic and biodistribution profiles than those from nanocarriers administered by the conventional route to improve the drug therapeutic index...
September 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28939481/laparoscopic-typical-and-atypical-locations-of-sentinel-node-mapping-with-indocyanine-green-comparison-of-two-near-infrared-fluorescence-systems
#13
Giampaolo Di Martino, Claudio Reato, Debora Verri, Federica Dell'Orto, Alessandro Buda
STUDY OBJECTIVE: To present our minimally invasive laparoscopic approach for sentinel lymph node (SLN) mapping with indocyanine green (ICG) fluorescence using with two florescence systems. DESIGN: step by step video description of the technique showing the most frequent typical and atypical location of SLN's (educational video). SETTING: Lymph node staging in apparent confined endometrial cancer. PATIENTS: women underwent sentinel node mapping in a minimally invasive setting...
September 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28935762/effect-of-different-anesthetic-methods-on-cellular-immune-functioning-and-the-prognosis-of-patients-with-ovarian-cancer-undergoing-oophorectomy
#14
Xin-Rui Han, Xin Wen, Yan-Yi Li, Shao-Hua Fan, Zi-Feng Zhang, Hong Li, Xing-Feng Sun, Gui-Qi Geng, Shen Sun, Shao-Qiang Huang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
This study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α and CA-125...
September 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28932352/novel-technique-of-abdominal-wall-nerve-block-for-laparoscopic-colostomy-rectus-sheath-block-with-transperitoneal-approach
#15
Jun Nagata, Jun Watanabe, Yusuke Sawatsubashi, Masaki Akiyama, Koichi Arase, Noritaka Minagawa, Takayuki Torigoe, Kotaro Hamada, Yoshifumi Nakayama, Keiji Hirata
A 62-year-old man who had acute rectal obstruction due to a large rectal cancer is presented. He underwent emergency laparoscopic colostomy. We used the laparoscopic puncture needle to inject analgesia with the novel transperitoneal approach. In this procedure, both ultrasound and laparoscopic images assisted with the accurate injection of analgesic to the correct layer. The combination of laparoscopic visualization and ultrasound imaging ensured infiltration of analgesic into the correct layer without causing damage to the bowel...
August 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28924368/the-effects-of-perioperative-anesthesia-and-analgesia-on-immune-function-in-patients-undergoing-breast-cancer-resection-a-prospective-randomized-study
#16
Jin Sun Cho, Mi-Hyang Lee, Seung Il Kim, Seho Park, Hyung Seok Park, Ein Oh, Jong Ho Lee, Bon-Nyeo Koo
Introduction: Perioperative anesthesia and analgesia exacerbate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. We compared the effects of two different anesthesia and analgesia methods on the NK cell cytotoxicity (NKCC) in patients undergoing breast cancer surgery. Methods: Fifty patients undergoing breast cancer resection were randomly assigned to receive propofol-remifentanil anesthesia with postoperative ketorolac analgesia (Propofol-ketorolac groups) or sevoflurane-remifentanil anesthesia with postoperative fentanyl analgesia (Sevoflurane-fentanyl group)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28911827/single-site-robot-assisted-laparoscopic-staging-surgery-for-presumed-clinically-early-stage-ovarian-cancer
#17
Ji Geun Yoo, Woo Jin Kim, Keun Ho Lee
STUDY OBJECTIVE: To present the demonstration of Robotic-assisted laparoendoscopic single-site(R-LESS) staging surgery in presumed clinically early stage ovarian cancer. DESIGN: A step-by-step presentation of the procedure using video (Canadian Task Force classification III). SETTING: A university hospital. INTERVENTION: A 29-year-old woman was referred from a local clinic for an 8x6cm sized left ovarian tumor suggesting malignancy...
September 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28905322/differences-in-immune-response-to-anesthetics-used-for-day-surgery-versus-hospitalization-surgery-for-breast-cancer-patients
#18
Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya, Morihito Okada
BACKGROUND: Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for breast cancer were compared in a prospective study. METHODS: Between February 2012 and August 2014, 21 breast cancer patients underwent day surgery and 16 breast cancer patients underwent hospitalization surgery. The former group received lidocaine/propofol/pethidine, while propofol/systemic opioid- and sevoflurane/propofol/systemic opioid-based anesthesia were administered to the latter group...
September 14, 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28901262/novel-findings-of-anti-cancer-property-of-propofol
#19
Jiaqiang Wang, Chien-Shan Cheng, Yan Lu, Xiaowei Ding, Minmin Zhu, Changhong Miao, Jiawei Chen
Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Recent attention has been drawn to explore the role and mechanisms of Propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of Propofol in cancer have been studied. However, the underlying mechanisms remain unclear. This review focuses on research advancements of the recent ten years and aims to provide a general overview of Propofol's malignance-modulating properties and the underlying molecular mechanisms...
September 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28900843/pressurized-intraperitoneal-aerosol-chemotherapy-pipac-procedure-for-non-resectable-peritoneal-carcinomatosis-with-video
#20
Jean-Baptiste Cazauran, Mohammad Alyami, Antoinette Lasseur, Isabo Gybels, Olivier Glehen, Naoual Bakrin
BACKGROUND: Peritoneal carcinomatosis (PC) is a common evolution of abdominal cancers and is associated with poor prognosis in the absence of aggressive multimodal therapy.1 Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a safe and innovative approach, which enhances the effect of chemotherapy 2 without reported renal/hepatic toxicity.3,4 It requires mastery of technical aspects to reduce postoperative morbidity, increase effectiveness, and prevent caregiver chemotherapy exposure...
September 12, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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