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Robert Langer

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https://www.readbyqxmd.com/read/27911849/scalable-manufacturing-of-biomimetic-moldable-hydrogels-for-industrial-applications
#1
Anthony C Yu, Haoxuan Chen, Doreen Chan, Gillie Agmon, Lyndsay M Stapleton, Alex M Sevit, Mark W Tibbitt, Jesse D Acosta, Tony Zhang, Paul W Franzia, Robert Langer, Eric A Appel
Hydrogels are a class of soft material that is exploited in many, often completely disparate, industrial applications, on account of their unique and tunable properties. Advances in soft material design are yielding next-generation moldable hydrogels that address engineering criteria in several industrial settings such as complex viscosity modifiers, hydraulic or injection fluids, and sprayable carriers. Industrial implementation of these viscoelastic materials requires extreme volumes of material, upwards of several hundred million gallons per year...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911829/supramolecular-pegylation-of-biopharmaceuticals
#2
Matthew J Webber, Eric A Appel, Brittany Vinciguerra, Abel B Cortinas, Lavanya S Thapa, Siddharth Jhunjhunwala, Lyle Isaacs, Robert Langer, Daniel G Anderson
The covalent modification of therapeutic biomolecules has been broadly explored, leading to a number of clinically approved modified protein drugs. These modifications are typically intended to address challenges arising in biopharmaceutical practice by promoting improved stability and shelf life of therapeutic proteins in formulation, or modifying pharmacokinetics in the body. Toward these objectives, covalent modification with poly(ethylene glycol) (PEG) has been a common direction. Here, a platform approach to biopharmaceutical modification is described that relies on noncovalent, supramolecular host-guest interactions to endow proteins with prosthetic functionality...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27856796/oral-ultra-long-lasting-drug-delivery-application-toward-malaria-elimination-goals
#3
Andrew M Bellinger, Mousa Jafari, Tyler M Grant, Shiyi Zhang, Hannah C Slater, Edward A Wenger, Stacy Mo, Young-Ah Lucy Lee, Hormoz Mazdiyasni, Lawrence Kogan, Ross Barman, Cody Cleveland, Lucas Booth, Taylor Bensel, Daniel Minahan, Haley M Hurowitz, Tammy Tai, Johanna Daily, Boris Nikolic, Lowell Wood, Philip A Eckhoff, Robert Langer, Giovanni Traverso
Efforts at elimination of scourges, such as malaria, are limited by the logistic challenges of reaching large rural populations and ensuring patient adherence to adequate pharmacologic treatment. We have developed an oral, ultra-long-acting capsule that dissolves in the stomach and deploys a star-shaped dosage form that releases drug while assuming a geometry that prevents passage through the pylorus yet allows passage of food, enabling prolonged gastric residence. This gastric-resident, drug delivery dosage form releases small-molecule drugs for days to weeks and potentially longer...
November 16, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27771050/progress-in-formulation-based-approaches-for-antiretrovirals
#4
Ameya R Kirtane, Robert Langer, Giovanni Traverso
The human immunodeficiency virus has infected millions of people and the epidemic continues to grow rapidly in some parts of the world. Antiretroviral (ARV) therapy has provided improved treatment and prolonged the life expectancy of patients. Moreover, there is growing interest in using ARVs to protect against new infections. Hence, ARVs have emerged as our primary strategy in combating the virus. Unfortunately, several challenges limit the optimal performance of these drugs. First, ARVs often require life-long use and complex dosing regimens...
October 19, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27754567/adhere-randomized-controlled-trial-comparing-renal-function-in-de-novo-kidney-transplant-recipients-receiving-prolonged-release-tacrolimus-plus-mmf-or-sirolimus
#5
Oleg O Rummo, Mario Carmellini, Lionel Rostaing, Rainer Oberbauer, Maarten H L Christiaans, Christiane Mousson, Robert M Langer, Franco Citterio, Bernard Charpentier, Malcolm Brown, Gbenga Kazeem, Frank Lehner
ADHERE was a randomized, open-label, Phase IV study comparing renal function at Week 52 post-kidney transplant, in patients who received prolonged-release tacrolimus-based immunosuppressive regimens. On days 0-27, patients received prolonged-release tacrolimus (initially 0.2mg/kg/day), corticosteroids and mycophenolate mofetil (MMF). Patients were randomized on Day 28 to receive either prolonged-release tacrolimus plus MMF (Arm 1) or prolonged-release tacrolimus (≥25% dose-reduction on Day 42) plus sirolimus (Arm 2)...
October 18, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27739624/phosphine-stabilized-borylenes-and-boryl-anions-as-ligands-redox-reactivity-in-boron-based-pincer-complexes
#6
Lisa Vondung, Nicolas Frank, Maximilian Fritz, Lukas Alig, Robert Langer
Stabilized borylenes (L2 BH:) with weakly π-accepting substituents L, such as phosphines, were previously believed to be unstable. In the current manuscript, we describe a series of complexes formally containing a phosphine-stabilized borylene or boryl anion. In contrast to common trivalent boron compounds, the boron-based ligands in this study act as electron-donating ligands. The reported iron hydride complexes exhibit a unique reactivity pattern, undergoing a reversible B-H reductive elimination concomitant with oxidation of the boron(I) center...
October 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27734871/in-vitro-and-ex-vivo-strategies-for-intracellular-delivery
#7
REVIEW
Martin P Stewart, Armon Sharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer, Klavs F Jensen
Intracellular delivery of materials has become a critical component of genome-editing approaches, ex vivo cell-based therapies, and a diversity of fundamental research applications. Limitations of current technologies motivate development of next-generation systems that can deliver a broad variety of cargo to diverse cell types. Here we review in vitro and ex vivo intracellular delivery approaches with a focus on mechanisms, challenges and opportunities. In particular, we emphasize membrane-disruption-based delivery methods and the transformative role of nanotechnology, microfluidics and laboratory-on-chip technology in advancing the field...
October 12, 2016: Nature
https://www.readbyqxmd.com/read/27730820/nanoparticle-based-drug-delivery-systems-a-commercial-and-regulatory-outlook-as-the-field-matures
#8
Héloïse Ragelle, Fabienne Danhier, Véronique Préat, Robert Langer, Daniel G Anderson
Nanomedicine has emerged as a major field of academic research with direct impact on human health. While a first generation of products has been successfully commercialized and has significantly contributed to enhance patient's life, recent advances in material design and the emergence of new therapeutics are contributing to the development of more sophisticated systems. As the field matures, it is important to comprehend the challenges related to nanoparticle commercial development for a more efficient and predictable path to the clinic...
October 12, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27702895/sustained-antigen-availability-during-germinal-center-initiation-enhances-antibody-responses-to-vaccination
#9
Hok Hei Tam, Mariane B Melo, Myungsun Kang, Jeisa M Pelet, Vera M Ruda, Maria H Foley, Joyce K Hu, Sudha Kumari, Jordan Crampton, Alexis D Baldeon, Rogier W Sanders, John P Moore, Shane Crotty, Robert Langer, Daniel G Anderson, Arup K Chakraborty, Darrell J Irvine
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Using HIV antigens, we found that administering a given total dose of antigen and adjuvant over 1-2 wk through repeated injections or osmotic pumps enhanced humoral responses, with exponentially increasing (exp-inc) dosing profiles eliciting >10-fold increases in antibody production relative to bolus vaccination post prime...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27701180/bilateral-endoscopic-lung-volume-reduction-in-patients-with-severe-emphysema
#10
Franziska C Trudzinski, Philipp M Lepper, Daniela Leppert, Frank Langer, Christian Lensch, Monika Flaig, Robert Bals, Heinrike Wilkens, Peter Minko, Sebastian Fähndrich
Reducing hyperinflated areas in chronic obstructive pulmonary disease, either surgically or endoscopically, leads to improvement of functional parameters. It is unclear if bilateral treatment with endobronchial valves (EBV) aiming at total lobar occlusion is beneficial. The aim of this study was to assess the results after staged bilateral endoscopic treatment with EBV. This is a retrospective analysis of patients with severe airflow obstruction, who were treated bilaterally with EBV in two stages, aiming at subsequent atelectasis...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27687562/state-dependent-and-independent-effects-of-dialyzing-excitatory-neuromodulator-receptor-antagonists-into-the-ventral-respiratory-column
#11
Thomas M Langer, Suzanne E Neumueller, Emma Crumley, Nicholas J Burgraff, Sawan Talwar, Matthew Robert Hodges, Lawrence G Pan, Hubert V Forster
Unilateral dialysis of the broad spectrum muscarinic receptor antagonist atropine (50 mM) into the ventral respiratory column (VRC; including the pre-Bӧtzinger Complex region) of awake goats increased pulmonary ventilation (V̇I) and breathing frequency (f), conceivably due to local compensatory increases in serotonin (5-HT) and substance P (SP) measured in effluent mock cerebral spinal fluid (mCSF). In contrast, unilateral dialysis of a triple cocktail of antagonists to muscarinic (atropine; 5 mM), neurokinin-1 (NK-1) and 5-HT2A receptors does not alter V̇I or f, but increases local SP...
September 29, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27686458/esicm-lives-2016-part-one-milan-italy-1-5-october-2016
#12
L Bos, L Schouten, L van Vught, M Wiewel, D Ong, O Cremer, A Artigas, I Martin-Loeches, A Hoogendijk, T van der Poll, J Horn, N Juffermans, M Schultz, N de Prost, T Pham, G Carteaux, A Mekontso Dessap, C Brun-Buisson, E Fan, G Bellani, J Laffey, A Mercat, L Brochard, B Maitre, P A Howells, D R Thickett, C Knox, D P Park, F Gao, O Tucker, T Whitehouse, D F McAuley, G D Perkins, T Pham, J Laffey, G Bellani, E Fan, L Pisani, J P Roozeman, F D Simonis, A Giangregorio, L R Schouten, S M Van der Hoeven, J Horn, A Serpa Neto, E Festic, A M Dondorp, S Grasso, L D Bos, M J Schultz, M Koster-Brouwer, D Verboom, B Scicluna, K van de Groep, J Frencken, M Schultz, T van der Poll, M Bonten, O Cremer, J I Ko, K S Kim, G J Suh, W Y Kwon, K Kim, J H Shin, O T Ranzani, E Prina, R Menendez, A Ceccato, R Mendez, C Cilloniz, A Gabarrus, M Ferrer, A Torres, A Urbano, L A Zhang, D Swigon, F Pike, R S Parker, G Clermont, C Scheer, S O Kuhn, A Modler, M Vollmer, C Fuchs, K Hahnenkamp, S Rehberg, M Gründling, A Taggu, N Darang, N Öveges, I László, K Tánczos, M Németh, G Lebák, B Tudor, D Érces, J Kaszaki, W Huber, D Trásy, Z Molnár, G Ferrara, V S Kanoore Edul, H S Canales, E Martins, C Canullán, G Murias, M O Pozo, J F Caminos Eguillor, M G Buscetti, C Ince, A Dubin, H D Aya, A Rhodes, N Fletcher, R M Grounds, M Cecconi, M Jacquet-Lagrèze, M Riche, R Schweizer, P Portran, W Fornier, M Lilot, J Neidecker, J L Fellahi, A Escoresca-Ortega, A Gutiérrez-Pizarraya, L Charris-Castro, Y Corcia-Palomo, E Fernandez-Delgado, J Garnacho-Montero, C Roger, L Muller, L Elotmani, J Lipman, J Y Lefrant, J A Roberts, R Muñoz-Bermúdez, M Samper, C Climent, F Vasco, V Sara, S Luque, N Campillo, S Grau Cerrato, J R Masclans, F Alvarez-Lerma, S Carvalho Brugger, G Jimenez Jimenez, M Miralbés Torner, J Trujillano Cabello, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, M Vallverdú Vidal, M Palomar Martínez, V Gusarov, D Shilkin, M Dementienko, E Nesterova, N Lashenkova, A Kuzovlev, M Zamyatin, A Demoule, S Carreira, S Lavault, O Palancca, E Morawiec, J Mayaux, I Arnulf, T Similowski, B S Rasmussen, R G Maltesen, M Hanifa, S Pedersen, S R Kristensen, R Wimmer, M Panigada, G Li Bassi, O T Ranzani, T Kolobow, A Zanella, M Cressoni, L Berra, V Parrini, H Kandil, G Salati, S Livigni, A Amatu, A Andreotti, F Tagliaferri, G Moise, G Mercurio, A Costa, A Vezzani, S Lindau, J Babel, M Cavana, D Consonni, A Pesenti, L Gattinoni, A Torres, P Mansouri, F Zand, L Zahed, F Dehghanrad, M Bahrani, M Ghorbani, B Cambiaghi, O Moerer, T Mauri, N Kunze-Szikszay, C Ritter, A Pesenti, M Quintel, L M Vilander, M A Kaunisto, S T Vaara, V Pettilä, J L G Haitsma Mulier, S Rozemeijer, A M E Spoelstra-de Man, P E Elbers, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, I H J Koh, M Galindo Martínez, R Jiménez Sánchez, L Martínez Gascón, M D Rodríguez Mulero, A Ortín Freire, A Ojados Muñoz, S Rebollo Acebes, Á Fernández Martínez, S Moreno Aliaga, L Herrera Para, J Murcia Payá, F Rodríguez Mulero, P Guerci, Y Ince, P Heeman, B Ergin, C Ince, Z Uz, M Massey, Y Ince, R Papatella, E Bulent, P Guerci, F Toraman, C Ince, E R Longbottom, H D Torrance, H C Owen, C J Hinds, R M Pearse, M J O'Dywer, Z Trogrlic, M van der Jagt, H Lingsma, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, T van Achterberg, J Bakker, D A M P J Gommers, E Ista, A Krajčová, P Waldauf, F Duška, A Shah, N Roy, S McKechnie, C Doree, S Fisher, S J Stanworth, J F Jensen, D Overgaard, M H Bestle, D F Christensen, I Egerod, A Pivkina, V Gusarov, I Zhivotneva, N Pasko, M Zamyatin, J F Jensen, I Egerod, M H Bestle, D F Christensen, A Alklit, R L Hansen, H Knudsen, L B Grode, D Overgaard, M Hravnak, L Chen, A Dubrawski, G Clermont, M R Pinsky, S M Parry, L D Knight, B C Connolly, C E Baldwin, Z A Puthucheary, L Denehy, N Hart, P E Morris, J Mortimore, C L Granger, H I Jensen, R Piers, B Van den Bulcke, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, B Van den Bulcke, R Piers, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere, L Zubek, P Maia, A Michalsen, J Decruyenaere, E Kompanje, S Vanheule, E Azoulay, S Vansteelandt, D Benoit, C Ryan, D Dawson, J Ball, K Noone, B Aisling, S Prudden, A Ntantana, D Matamis, S Savvidou, M Giannakou, M Gouva, G Nakos, V Koulouras, J Aron, G Lumley, D Milliken, K Dhadwal, B A McGrath, S J Lynch, B Bovento, G Sharpe, E Grainger, S Pieri-Davies, S Wallace, B McGrath, S J Lynch, B Bovento, E Grainger, S Pieri-Davies, G Sharpe, S Wallace, M Jung, J Cho, H Park, G Suh, O Kousha, J Paddle, L Gamrin Gripenberg, M Sundström Rehal, J Wernerman, O Rooyackers, H J de Grooth, W P Choo, A M Spoelstra-de Man, E L Swart, H M Oudemans-van Straaten, L Talan, G Güven, N D Altıntas, M Padar, G Uusvel, L Starkopf, J Starkopf, A Reintam Blaser, M S Kalaiselvan, A S Arunkumar, M K Renuka, R L Shivkumar, M Volbeda, D Ten Kate, M Hoekstra, J M van der Maaten, M W Nijsten, A Komaromi, O Rooyackers, J Wernerman, Å Norberg, M Smedberg, M Mori, L Pettersson, Å Norberg, O Rooyackers, J Wernerman, M Theodorakopoulou, T Christodoulopoulou, A Diamantakis, F Frantzeskaki, M Kontogiorgi, E Chrysanthopoulou, M Lygnos, C Diakaki, A Armaganidis, K Gundogan, E Dogan, R Coskun, S Muhtaroglu, M Sungur, T Ziegler, M Guven, A Kleyman, W Khaliq, D Andreas, M Singer, R Meierhans, R Schuepbach, I De Brito-Ashurst, F Zand, G Sabetian, R Nikandish, F Hagar, M Masjedi, B Maghsudi, A Vazin, M Ghorbani, E Asadpour, K C Kao, L C Chiu, C Y Hung, C H Chang, S H Li, H C Hu, S El Maraghi, M Ali, D Rageb, M Helmy, J Marin-Corral, C Vilà, J R Masclans, A Vàzquez, I Martín-Loeches, E Díaz, J C Yébenes, A Rodriguez, F Álvarez-Lerma, N Varga, A Cortina-Gutiérrez, L Dono, M Martínez-Martínez, C Maldonado, E Papiol, M Pérez-Carrasco, R Ferrer, K Nweze, B Morton, I Welters, M Houard, B Voisin, G Ledoux, S Six, E Jaillette, S Nseir, S Romdhani, R Bouneb, D Loghmari, N Ben Aicha, J Ayachi, K Meddeb, I Chouchène, A Khedher, M Boussarsar, K S Chan, W L Yu, J Marin-Corral, C Vilà, J R Masclans, J Nolla, L Vidaur, J Bonastre, B Suberbiola, J E Guerrero, A Rodriguez, N Ramon Coll, G Jiménez Jiménez, S Carvalho Brugger, J Codina Calero, B Balsera Garrido, M García, M Palomar Martínez, M Vallverdú Vidal, M C de la Torre, E Vendrell, E Palomera, E Güell, J C Yébenes, M Serra-Prat, J F Bermejo-Martín, J Almirall, E Tomas, A Escoval, F Froe, M H Vitoria Pereira, N Velez, E Viegas, E Filipe, C Groves, M Reay, L C Chiu, H C Hu, C Y Hung, C H Chang, S H Li, K C Kao, A Ballin, F Facchin, G Sartori, F Zarantonello, E Campello, C M Radu, S Rossi, C Ori, P Simioni, N Umei, I Shingo, A C Santos, C Candeias, I Moniz, R Marçal, Z Costa E Silva, J M Ribeiro, J F Georger, J P Ponthus, M Tchir, V Amilien, M Ayoub, E Barsam, G Martucci, G Panarello, F Tuzzolino, G Capitanio, V Ferrazza, T Carollo, L Giovanni, A Arcadipane, M López Sánchez, M A González-Gay, F J Llorca Díaz, M I Rubio López, E Zogheib, L Villeret, J Nader, M Bernasinski, P Besserve, T Caus, H Dupont, P Morimont, S Habran, R Hubert, T Desaive, F Blaffart, N Janssen, J Guiot, A Pironet, P Dauby, B Lambermont, F Zarantonello, A Ballin, F Facchin, G Sartori, E Campello, T Pettenuzzo, G Citton, S Rossi, P Simioni, C Ori, C Kirakli, O Ediboglu, S Ataman, M Yarici, F Tuksavul, S Keating, A Gibson, M Gilles, M Dunn, G Price, N Young, P Remeta, P Bishop, M D Fernández Zamora, J Muñoz-Bono, E Curiel-Balsera, E Aguilar-Alonso, R Hinojosa, A Gordillo-Brenes, J A Arboleda-Sánchez, I Skorniakov, D Vikulova, C Whiteley, O Shaikh, A Jones, M Ostermann, L Forni, M Scott, J Sahatjian, W Linde-Zwirble, D Hansell, P Laoveeravat, N Srisawat, M Kongwibulwut, S Peerapornrattana, N Suwachittanont, T O Wirotwan, P Chatkaew, P Saeyub, K Latthaprecha, K Tiranathanagul, S Eiam-Ong, J A Kellum, R E Berthelsen, A Perner, A E K Jensen, J U Jensen, M H Bestle, D J Gebhard, J Price, C E Kennedy, A Akcan-Arikan, A M A Liberatore, R B Souza, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, K Hamed, M M Khaled, R Aly Soliman, M Sherif Mokhtar, G Seller-Pérez, D Arias-Verdú, E Llopar-Valdor, I De-Diós-Chacón, G Quesada-García, M E Herrera-Gutierrez, R Hafes, G Carroll, P Doherty, C Wright, I G Guerra Vera, M Ralston, M L Gemmell, A MacKay, E Black, C Wright, R I Docking, R Appleton, M R Ralston, L Gemmell, R Appleton, C Wright, R I Docking, E Black, A Mackay, S Rozemeijer, J L G Haitsma Mulier, J G Röttgering, P W G Elbers, A M E Spoelstra-de Man, P R Tuinman, M C de Waard, H M Oudemans-van Straaten, N Mejeni, J Nsiala, A Kilembe, P Akilimali, G Thomas, I Egerod, A E Andersson, A M Fagerdahl, V Knudsen, K Meddeb, A Ben Cheikh, Y Hamdaoui, J Ayachi, A Guiga, N Fraj, S Romdhani, N Sma, R Bouneb, I Chouchene, A Khedher, N Bouafia, M Boussarsar, A Amirian, B Ziaian, M Masjedi, C Fleischmann, D O Thomas-Rueddel, A Schettler, D Schwarzkopf, A Stacke, K Reinhart, E Filipe, A Escoval, A Martins, P Sousa, N Velez, E Viegas, E Tomas, G Snell, R Matsa, T T S Paary, M S Kalaiselvan, A M Cavalheiro, L L Rocha, C S Vallone, A Tonilo, M D S Lobato, D T Malheiro, G Sussumo, N M Lucino, F Zand, V D Rosenthal, M Masjedi, G Sabetian, B Maghsudi, M Ghorbani, A Sanaei Dashti, A Yousefipour, J R Goodall, M Williamson, E Tant, N Thomas, C Balci, C Gonen, E Haftacı, H Gurarda, E Karaca, B Paldusová, I Zýková, D Šímová, S Houston, L D'Antona, J Lloyd, V Garnelo-Rey, M Sosic, V Sotosek-Tokmazic, J Kuharic, I Antoncic, S Dunatov, A Sustic, C T Chong, M Sim, T Lyovarin, F M Acosta Díaz, S Narbona Galdó, M Muñoz Garach, O Moreno Romero, A M Pérez Bailón, A Carranza Pinel, M Colmenero, A Gritsan, A Gazenkampf, E Korchagin, N Dovbish, R M Lee, M P P Lim, C T Chong, B C L Lim, J J See, R Assis, F Filipe, N Lopes, L Pessoa, T Pereira, N Catorze, M S Aydogan, C Aldasoro, P Marchio, A Jorda, M D Mauricio, S Guerra-Ojeda, M Gimeno-Raga, M Colque-Cano, A Bertomeu-Artecero, M Aldasoro, S L Valles, D Tonon, T Triglia, J C Martin, M C Alessi, N Bruder, P Garrigue, L Velly, S Spina, V Scaravilli, C Marzorati, E Colombo, D Savo, A Vargiolu, G Cavenaghi, G Citerio, A H V Andrade, P Bulgarelli, J A P Araujo, V Gonzalez, V A Souza, A Costa, C Massant, C A C Abreu Filho, R A Morbeck, L E Burgo, R van Groenendael, L T van Eijk, G P Leijte, B Koeneman, M Kox, P Pickkers, A García-de la Torre, M de la Torre-Prados, A Fernández-Porcel, C Rueda-Molina, P Nuevo-Ortega, T Tsvetanova-Spasova, E Cámara-Sola, A García-Alcántara, L Salido-Díaz, X Liao, T Feng, J Zhang, X Cao, Q Wu, Z Xie, H Li, Y Kang, M S Winkler, A Nierhaus, E Mudersbach, A Bauer, L Robbe, C Zahrte, E Schwedhelm, S Kluge, C Zöllner, B Morton, E Mitsi, S H Pennington, J Reine, A D Wright, R Parker, I D Welters, J D Blakey, G Rajam, E W Ades, D M Ferreira, D Wang, A Kadioglu, S B Gordon, R Koch, M Kox, J Rahamat-Langedoen, J Schloesser, M de Jonge, P Pickkers, J Bringue, R Guillamat-Prats, E Torrents, M L Martinez, M Camprubí-Rimblas, A Artigas, L Blanch, S Y Park, Y B Park, D K Song, S Shrestha, S H Park, Y Koh, M J Park, C W Hong, O Lesur, D Coquerel, X Sainsily, J Cote, T Söllradl, A Murza, L Dumont, R Dumaine, M Grandbois, P Sarret, E Marsault, D Salvail, M Auger-Messier, F Chagnon, M P Lauretta, E Greco, A Dyson, M Singer, S Preau, M Ambler, A Sigurta, S Saeed, M Singer, L Topcu Sarıca, N Zibandeh, D Genc, F Gul, T Akkoc, E Kombak, L Cinel, T Akkoc, I Cinel, S J Pollen, N Arulkumaran, M Singer, H D Torrance, E R Longbottom, G Warnes, C J Hinds, D J Pennington, K Brohi, M J O'Dwyer, H Y Kim, S Na, J Kim, Y F Chang, A Chao, P Y Shih, C T Lee, Y C Yeh, L W Chen, M Adriaanse, Z Trogrlic, E Ista, H Lingsma, W Rietdijk, H H Ponssen, J F Schoonderbeek, F Schreiner, S J Verbrugge, S Duran, D A M P J Gommers, M van der Jagt, S Funcke, S Sauerlaender, B Saugel, H Pinnschmidt, D A Reuter, R Nitzschke, S Perbet, C Biboulet, A Lenoire, D Bourdeaux, B Pereira, B Plaud, J E Bazin, V Sautou, A Mebazaa, J M Constantin, M Legrand, Y Boyko, P Jennum, M Nikolic, H Oerding, R Holst, P Toft, H K Nedergaard, T Haberlandt, H I Jensen, P Toft, S Park, S Kim, Y J Cho, Y J Lim, A Chan, S Tang, S L Nunes, S Forsberg, H Blomqvist, L Berggren, M Sörberg, T Sarapohja, C J Wickerts, J G M Hofhuis, L Rose, B Blackwood, E Akerman, J Mcgaughey, I Egerod, M Fossum, H Foss, E Georgiou, H J Graff, M Kalafati, R Sperlinga, A Schafer, A G Wojnicka, P E Spronk, F Zand, F Khalili, R Afshari, G Sabetian, M Masjedi, B Maghsudi, H Haddad Khodaei, S Javadpour, P Petramfar, S Nasimi, A Vazin, B Ziaian, H Tabei, A Gunther, J O Hansen, P Sackey, H Storm, J Bernhardsson, Ø Sundin, A Bjärtå, A Bienert, P Smuszkiewicz, P Wiczling, K Przybylowski, A Borsuk, I Trojanowska, J Matysiak, Z Kokot, M Paterska, E Grzeskowiak, A Messina, E Bonicolini, D Colombo, G Moro, S Romagnoli, A R De Gaudio, F Della Corte, S M Romano, J A Silversides, E Major, E E Mann, A J Ferguson, D F Mcauley, J C Marshall, B Blackwood, E Fan, J A Diaz-Rodriguez, R Silva-Medina, E Gomez-Sandoval, N Gomez-Gonzalez, R Soriano-Orozco, P L Gonzalez-Carrillo, M Hernández-Flores, K Pilarczyk, J Lubarksi, D Wendt, F Dusse, J Günter, B Huschens, E Demircioglu, H Jakob, A Palmaccio, A M Dell'Anna, D L Grieco, F Torrini, C Iaquaniello, F Bongiovanni, M Antonelli, L Toscani, D Antonakaki, D Bastoni, H D Aya, A Rhodes, M Cecconi, M Jozwiak, F Depret, J L Teboul, J Alphonsine, C Lai, C Richard, X Monnet, I László, G Demeter, N Öveges, K Tánczos, M Németh, D Trásy, I Kertmegi, D Érces, B Tudor, J Kaszaki, Z Molnár, A Hasanin, A Lotfy, A El-Adawy, H Nassar, S Mahmoud, A Abougabal, A Mukhtar, F Quinty, S Habchi, A Luzi, E Antok, G Hernandez, B Lara, L Enberg, M Ortega, P Leon, C Kripper, P Aguilera, E Kattan, J Bakker, W Huber, M Lehmann, S Sakka, B Bein, R M Schmid, J Preti, J Creteur, A Herpain, J Marc, E Zogheib, F Trojette, S Bar, L Kontar, D Titeca, J Richecoeur, B Gelee, N Verrier, R Mercier, E Lorne, J Maizel, H Dupont, M Slama, M E Abdelfattah, A Eladawy, M A Ali Elsayed, A Mukhtar, A Pedraza Montenegro, E Monares Zepeda, J Franco Granillo, J S Aguirre Sánchez, G Camarena Alejo, A Rugerio Cabrera, A A Tanaka Montoya, C Lee, F Hatib, M Cannesson, P Theerawit, T Morasert, Y Sutherasan, G Zani, S Mescolini, M Diamanti, R Righetti, A Scaramuzza, M Papetti, M Terenzoni, C Gecele, M Fusari, K A Hakim, A Chaari, M Ismail, A H Elsaka, T M Mahmoud, K Bousselmi, V Kauts, W F Casey, S D Hutchings, D Naumann, J Wendon, S Watts, E Kirkman, Z Jian, S Buddi, C Lee, J Settels, F Hatib, M R Pinsky, P Bertini, F Guarracino, C Trepte, P Richter, S A Haas, V Eichhorn, J C Kubitz, D A Reuter, M S Soliman, W I Hamimy, A Z Fouad, A M Mukhtar, M Charlton, L Tonks, L Mclelland, T J Coats, J P Thompson, M R Sims, D Williams, D Z Roushdy, R A Soliman, R A Nahas, M Y Arafa, W T Hung, C C Chiang, W C Huang, K C Lin, S C Lin, C C Cheng, P L Kang, S R Wann, G Y Mar, C P Liu, M Lopez Carranza, H Sancho Fernandez, J A Sanchez Roman, F Lucena, A Campanario Garcia, A Loza Vazquez, A Lesmes Serrano, L Sayagues Moreira, R Vidal-Perez, U Anido Herranz, J M Garcia Acuna, C Pena Gil, J L Garcia Allut, P Rascado Sedes, C Martin Lopez, E Saborido Paz, C Galban Rodriguez, J R Gonzalez-Juanatey, A Vallejo-Baez, M V de la Torre-Prados, P Nuevo-Ortega, A Fernández-Porcel, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, J Aron, R Marharaj, K Gervasio, M Bottiroli, M Mondino, D De Caria, A Calini, E Montrasio, F Milazzo, M P Gagliardone, A Vallejo-Báez, M V de la Torre-Prados, P Nuevo-Ortega, A Fernández-Porcel, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, L Sayagues Moreira, R Vidal-Perez, U Anido, C Pena Gil, J M Garcia Acuna, P Rascado Sedes, C Martin Lopez, E Saborido Paz, J L Garcia Allut, C Galban Rodriguez, J R Gonzalez-Juanatey, Y Hamdaoui, A Khedher, M Cheikh-Bouhlel, J Ayachi, K Meddeb, N Sma, N Fraj, N Ben Aicha, S Romdhani, R Bouneb, I Chouchene, M Boussarsar, M P R D L Dela Cruz, J M Bernardo, F Galfo, A Dyson, M Singer, A Marino, A Dyson, M Singer, C C Chao, P Hou, W C Huang, C C Hung, C H Chiang, W T Hung, K C Lin, S C Lin, Y J Liou, S M Hung, Y S Lin, C C Cheng, F Y Kuo, K R Chiou, C J Chen, L S Yan, C Y Liu, H H Wang, P L Kang, H L Chen, C K Ho, G Y Mar, C P Liu, S Grewal, S Gopal, C Corbett, A Wilson, J Capps, W Ayoub, A Lomas, S Ghani, J Moore, D Atkinson, M Sharman, W Swinnen, J Pauwels, K Mignolet, E Pannier, A Koch, T Sarens, W Temmerman, A M Elmenshawy, A M Fayed, M Elboriuny, E Hamdy, E Zakaria, A C Falk, A Petosic, K Olafsen, H Wøien, H Flaatten, K Sunde, J J Cáceres Agra, J L Santana Cabrera, J D Martín Santana, L Melián Alzola, H Rodríguez Pérez, T Castro Pires, H Calderón, A Pereira, S Castro, C Granja, I Norkiene, I Urbanaviciute, G Kezyte, D Ringaitiene, T Jovaisa, G Vogel, U B Johansson, A Sandgren, C Svensen, E Joelsson-Alm, M A Leite, L D Murbach, E F Osaku, C R L M Costa, M Pelenz, N M Neitzke, M M Moraes, J L Jaskowiak, M M M Silva, R S Zaponi, L R L Abentroth, S M Ogasawara, A C Jorge, P A D Duarte, L D Murbach, M A Leite, E F Osaku, J Barreto, S T Duarte, S Taba, D Miglioranza, D P Gund, C F Lordani, C R L M Costa, S M Ogasawara, A C Jorge, P A D Duarte, H Vollmer, M Gager, C Waldmann, A T Mazzeo, R Tesio, C Filippini, M E Vallero, C Giolitti, S Caccia, M Medugno, T Tenaglia, R Rosato, I Mastromauro, L Brazzi, P P Terragni, R Urbino, V Fanelli, V M Ranieri, L Mascia, J Ballantyne, L Paton, A Mackay, P Perez-Teran, O Roca, J C Ruiz-Rodriguez, A Zapatero, J Serra, J R Masclans, S Bianzina, P Cornara, G Rodi, G Tavazzi, M Pozzi, G A Iotti, F Mojoli, A Braschi, A Vishnu, D Buche, R Pande, D L J Moolenaar, F Bakhshi-Raiez, D A Dongelmans, N F de Keizer, D W de Lange, I Fuentes Fernández, D Martínez Baño, J L Buendía Moreno, R Jara Rubio, J Scott, D Phelan, D Morely, J O'Flynn, P Stapleton, M Lynch, B Marsh, E Carton, C O'Loughlin, K C Cheng, M I Sung, M O Elghonemi, M H Saleh, T S Meyhoff, M Krag, P B Hjortrup, A Perner, M H Møller, T Öhman, T Sigmundsson, E Redondo, M Hallbäck, F Suarez-Sipmann, H Björne, C Hällsjö Sander, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, M Guanziroli, G Vergani, T Tonetti, I Tomic, A Colombo, F Crimella, E Carlesso, A Colombo, V Gasparovic, L Gattinoni, R El-Sherif, M Abd Al-Basser, A Raafat, A El-Sherif, F D Simonis, L R A Schouten, O L Cremer, D S Y Ong, G Amoruso, G Cinnella, M J Schultz, L D J Bos, W Huber, P Schmidle, M Findeisen, P Hoppmann, J Jaitner, F Brettner, R M Schmid, T Lahmer, E Festic, G Rajagopalan, V Bansal, R Frank, R Hinds, J Levitt, S Siddiqui, J P Gilbert, K Sim, C H Wang, H C Hu, I J Li, W R Tang, K C Kao, P Persona, A De Cassai, M Franco, F Facchin, C Ori, S Rossi, A Goffi, S H Li, H C Hu, L C Chiu, C Y Hung, C H Chang, K C Kao, B Llorente Ruiz, J Lujan Varas, R Molina Montero, C Pintado Delgado, O Navarrete, M Vazquez Mezquita, E Alonso Peces, M A M Nakamura, L A Hajjar, F R B G Galas, T A Ortiz, M B P Amato, L Bitker, N Costes, D Le Bars, F Lavenne, D Mojgan, J C Richard, C Chiurazzi, M Cressoni, D Massari, M Guanziroli, G Vergani, M Gotti, M Brioni, I Algieri, P Cadringher, T Tonetti, D Chiumello, L Gattinoni, A Zerman, M Türkoğlu, G Arık, F Yıldırım, Z Güllü, I Kara, N Boyacı, B Basarık Aydoğan, Ü Gaygısız, K Gönderen, G Aygencel, M Aydoğdu, Z Ülger, G Gürsel, J Riera, C Maldonado Toral, C Mazo, M Martínez, J Baldirà, L Lagunes, A Roman, M Deu, J Rello, D J Levine, R M Mohus, Å Askim, J Paulsen, A Mehl, A T Dewan, J K Damås, E Solligård, B O Åsvold, J Paulsen, Å Askim, R M Mohus, A Mehl, A DeWan, E Solligård, J K Damås, B O Åsvold, O Aktepe, A Kara, H Yeter, A Topeli, M Norrenberg, M Devroey, H Khader, J C Preiser, Z Tang, C Qiu, L Tong, C Cai, M Theodorakopoulou, A Diamantakis, M Kontogiorgi, E Chrysanthopoulou, T Christodoulopoulou, F Frantzeskaki, M Lygnos, O Apostolopoulou, A Armaganidis, J Y Moon, M R Park, I S Kwon, G R Chon, J Y Ahn, S J Kwon, Y J Chang, J Y Lee, S Y Yoon, J W Lee, M Kostalas, J Mckinlay, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, N D Altintas, S Izdes, O Keremoglu, A Alkan, S Neselioglu, O Erel, N Tardif, T Gustafsson, O Rooyackers, K N MacEachern, M Traille, I Bromberg, S E Lapinsky, M J Moore, Z Tang, C Cai, L Tong, J L García-Garmendia, F Villarrasa-Clemente, F Maroto-Monserrat, O Rufo-Tejeiro, V Jorge-Amigo, M Sánchez-Santamaría, C Colón-Pallarés, A Barrero-Almodóvar, S Gallego-Lara, C T Anthon, R B Müller, N Haase, K Møller, P B Hjortrup, J Wetterslev, A Perner, M Nakanishi, A Kuriyama, T Fukuoka, M A Abd El Halim, M H Elsaid Hafez, A M Moktar, A Eladawy, H M Elazizy, K Abdel Hakim, A Chaari, M Elbahr, M Ismail, T Mahmoud, V Kauts, K Bousselmi, E Khalil, W Casey, S H Zaky, A Rizk, M O Elghonemi, R Ahmed, J C F Vieira, R B Souza, A M A Liberatore, I H J Koh, G A Ospina-Tascón, A F Garcia Marin, G J Echeverry, W F Bermudez, H J Madriñan-Navia, J D Valencia, E Quiñonez, A Marulanda, C A Arango-Dávila, A Bruhn, G Hernandez, D De Backer, D Orbegozo Cortes, F Su, J L Vincent, J Creteur, L Tullo, L Mirabella, P Di Molfetta, G Cinnella, M Dambrosio, C Villavicencio Lujan, J Leache Irigoyen, M Cartanya Ferré, R Carbonell García, A Mukhtar, M Ahmed, M El Ayashi, A Hasanin, E Ayman, M Salem, A Eladawy, S Fathy, H Nassar, A Zaghlol, M F Aguilar Arzapalo, Å Valsø, K Sunde, T Rustøen, I Schou-Bredal, L Skogstad, K Tøien, C Padilla, Y Palmeiro, W Egbaria, R Kigli, B Maertens, K Blot, S Blot, E Santana-Santos, E R Dos Santos, R E D L Ferretti-Rebustini, R D C C D O Dos Santos, R G S Verardino, L A Bortolotto, A M Doyle, I Naldrett, J Tillman, S Price, S Shrestha, P Pearson, J Greaves, D Goodall, A Berry, A Richardson, G O Odundo, P Omengo, P Obonyo, N M Chanzu, R Kleinpell, S J Sarris, P Nedved, M Heitschmidt, H Ben-Ghezala, S Snouda, S Djobbi, H Ben-Ghezala, S Snouda, L Rose, N K J Adhikari, D Leasa, D Fergusson, D A Mckim, J Weblin, O Tucker, D McWilliams, F Doesburg, F Cnossen, W Dieperink, W Bult, M W N Nijsten, G A Galvez-Blanco, E Monares Zepeda, C I Olvera Guzman, J S Aguirre Sánchez, J Franco Granillo, J Santos Stroud, R Thomson, M Llaurado-Serra, A Lobo-Civico, M Pi-Guerrero, I Blanco-Sanchez, A Piñol-Tena, C Paños-Espinosa, Y Alabart-Segura, B Coloma-Gomez, A Fernandez-Blanco, F Braga-Dias, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, R Prada, P Juárez, R Argandoña, J J Díaz, C Sánchez Ramirez, P Saavedra, S Ruiz Santana, O Obukhova, S Kashiya, I A Kurmukov, A M Pronina, P Simeone, L Puybasset, G Auzias, O Coulon, B Lesimple, G Torkomian, L Velly, A Bienert, A Bartkowska-Sniatkowska, P Wiczling, O Szerkus, D Siluk, J Bartkowiak-Wieczorek, J Rosada-Kurasinska, J Warzybok, A Borsuk, R Kaliszan, E Grzeskowiak, C Hernandez Caballero, S Roberts, G Isgro, D Hall, G Guillaume, O Passouant, F Dumas, W Bougouin, B Champigneulle, M Arnaout, J Chelly, J D Chiche, O Varenne, J P Mira, E Marijon, A Cariou, M Beerepoot, H R Touw, K Parlevliet, C Boer, P W Elbers, P R Tuinman, Á J Roldán Reina, Y Corcia Palomo, R Martín Bermúdez, L Martín Villén, I Palacios García, J R Naranjo Izurieta, J B Pérez Bernal, F J Jiménez Jiménez, F Cota-Delgado, M V de la Torre-Prados, A Fernández-Porcel, P Nuevo-Ortega, E Cámara-Sola, T Tsvetanova-Spasova, C Rueda-Molina, L Salido-Díaz, A García-Alcántara, T Kaneko, H Tanaka, M Kamikawa, R Karashima, S Iwashita, H Irie, S Kasaoka, O Arola, R Laitio, A Saraste, J Airaksinen, M Pietilä, M Hynninen, J Wennervirta, M Bäcklund, E Ylikoski, P Silvasti, E Nukarinen, J Grönlund, V P Harjola, J Niiranen, K Korpi, M Varpula, R O Roine, T Laitio, S Salah, B G Hassen, A Mohamed Fehmi, S Kim, Y C Hsu, J Barea-Mendoza, C García-Fuentes, M Castillo-Jaramillo, H Dominguez-Aguado, R Viejo-Moreno, L Terceros-Almanza, S Bermejo Aznárez, C Mudarra-Reche, W Xu, M Chico-Fernández, J C Montejo-González, K Crewdson, M Thomas, M Merghani, L Fenner, P Morgan, D Lockey, E J van Lieshout, B Oomen, J M Binnekade, D A Dongelmans, R J de Haan, N P Juffermans, M B Vroom, R Algarte, L Martínez, B Sánchez, I Romero, F Martínez, S Quintana, J Trenado, O Sheikh, D Pogson, R Clinton, F Riccio, L Gemmell, A MacKay, A Arthur, L Young, A Sinclair, D Markopoulou, K Venetsanou, L Filippou, E Salla, S Stratouli, I Alamanos, A H Guirgis, R Gutiérrez Rodriguez, M J Furones Lorente, I Macias Guarasa, A Ukere, S Meisner, G Greiwe, B Opitz, D Benten, B Nashan, L Fischer, C J C Trepte, D A Reuter, S A Haas, C R Behem, G Tavazzi, B Ana, A Vazir, D Gibson, S Price, M Masjedi, M R Hadavi, M Riahi Alam, M R Sasani, N Parenti, F Agrusta, C Palazzi, B Pifferi, R Sganzerla, F Tagliazucchi, A Luciani, M Möller, J Müller-Engelmann, G Montag, P Adams, C Lange, J Neuzner, R Gradaus, K H Wodack, F Thürk, A D Waldmann, M F Grässler, S Nishimoto, S H Böhm, E Kaniusas, D A Reuter, C J Trepte, T Sigmundsson, T Öhman, E Redondo, M Hallbäck, M Wallin, F Suarez Sipman, A Oldner, C Hällsjö Sander, H Björne, L Colinas, G Hernandez, R Vicho, M Serna, R Cuena, A Canabal, A Chaari, K Abdel Hakim, M Etman, M El Bahr, A El Sakka, K Bousselmi, A Arali, V Kauts, W F Casey, O Bond, P De Santis, E Iesu, F Franchi, J L Vincent, J Creteur, S Scolletta, F S Taccone, Z Marutyan, L Hamidova, A Shakotko, V Movsisyan, I Uysupova, A Evdokimov, S Petrikov, C Gonen, E Haftacı, C Balci, F J Redondo Calvo, N Bejarano, V Baladron, R Villazala, J Redondo, D Padilla, P Villarejo, A Akcan-Arikan, C E Kennedy, M F Aguilar Arzapalo, C Gomez-Gonzalez, S Mas-Font, A Puppo-Moreno, M Herrera-Gutierrez, M Garcia-Garcia, S Aldunate-Calvo, E P Plata-Menchaca, X L Pérez-Fernández, M Estruch, A Betbese-Roig, P Cárdenas Campos, M Rojas Lora, N D Toapanta Gaibor, R S Contreras Medina, V D Gumucio Sanguino, E J Casanova, J Sabater Riera, K Kritmetapak, S Peerapornratana, P Kittiskulnam, T Dissayabutra, K Tiranathanagul, P Susantithapong, K Praditpornsilpa, K Tungsanga, S Eiam-Ong, N Srisawat, T Winkelmann, T Busch, J Meixensberger, S Bercker, E M Flores Cabeza, M Sánchez Sánchez, N Cáceres Giménez, C Gutierrez Melón, E Herrero de Lucas, P Millán Estañ, M Hernández Bernal, A Garcia de Lorenzo Y Mateos, B Ergin, P Guerci, P A C Specht, Y Ince, C Ince, M Balik, M Zakharchenko, F Los, H Brodska, C de Tymowski, P Augustin, M Desmard, P Montravers, S N Stapel, R de Boer, H M Oudemans, A Hollinger, T Schweingruber, F Jockers, M Dickenmann, M Siegemund, N Runciman, M Ralston, R Appleton, T Mauri, L Alban, C Turrini, T Sasso, T Langer, M Panigada, P Taccone, E Carlesso, C Marenghi, G Grasselli, A Pesenti, P Wibart, T Reginault, M Garcia, B Barbrel, A Benard, C Bader, F Vargas, H N Bui, G Hilbert, J M Serrano Simón, P Carmona Sánchez, F Ruiz Ferrón, M García de Acilu, J Marin, V Antonia, L Ruano, M Monica, R Ferrer, J R Masclans, O Roca, G Hong, D H Kim, Y S Kim, J S Park, Y K Jee, Z Yu Xiang, W Jia-Xing, W Xiao Dan, N Wen Long, W Yu, Z Yan, X Cheng, T Kobayashi, Y Onodera, R Akimoto, A Sugiura, H Suzuki, M Iwabuchi, M Nakane, K Kawamae, P Carmona Sanchez, M D Bautista Rodriguez, M Rodriguez Delgado, V Martínez de Pinillos Sánchez, A Mula Gómez, J M Serrano Simón, P Beuret, C Fortes, M Lauer, M Reboul, J C Chakarian, X Fabre, B Philippon-Jouve, S Devillez, M Clerc, N Rittayamai, M Sklar, M Dres, M Rauseo, C Campbell, B West, D E Tullis, L Brochard, Y Onodera, R Akimoto, H Suzuki, M Okada, M Nakane, K Kawamae, N Ahmad, M Wood, A Glossop, J Higuera Lucas, A Blandino Ortiz, D Cabestrero Alonso, R De Pablo Sánchez, L Rey González, R Costa, G Spinazzola, A Pizza, G Ferrone, M Rossi, M Antonelli, G Conti, H Ribeiro, J Alves, M Sousa, P Reis, C S Socolovsky, R P Cauley, J E Frankel, A L Beam, K O Olaniran, F K Gibbons, K B Christopher, J Pennington, P Zolfaghari, H S King, H H Y Kong, H P Shum, W W Yan, C Kaymak, N Okumus, A Sari, B Erdogdu, S Aksun, H Basar, A Ozcan, N Ozcan, D Oztuna, J A Malmgren, S Lundin, K Torén, M Eckerström, A Wallin, A C Waldenström, F C Riccio, D Pogson, A C P Antonio, A F Leivas, F Kenji, E James, P Morgan, G Carroll, L Gemmell, A MacKay, C Wright, J Ballantyne, S Jonnada, C S Gerrard, N Jones, J D Salciccioli, D C Marshall, M Komorowski, A Hartley, M C Sykes, R Goodson, J Shalhoub, J R Fernández Villanueva, R Fernández Garda, A M López Lago, E Rodríguez Ruiz, R Hernández Vaquero, C Galbán Rodríguez, E Varo Pérez, C Hilasque, I Oliva, G Sirgo, M C Martin, M Olona, M C Gilavert, M Bodí, C Ebm, G Aggarwal, S Huddart, N Quiney, M Cecconi, S M Fernandes, J Santos Silva, J Gouveia, D Silva, R Marques, H Bento, A Alvarez, Z Costa Silva, D Díaz Diaz, M Villanova Martínez, E Palencia Herrejon, A Martinez de la Gandara, G Gonzalo, M A Lopez, P Ruíz de Gopegui Miguelena, C I Bernal Matilla, P Sánchez Chueca, M D C Rodríguez Longares, R Ramos Abril, A L Ruíz Aguilar, R Garrido López de Murillas, R Fernández Fernández, P Morales Laborías, M A Díaz Castellanos, M E Morales Laborías, J Cho, J Kim, J Park, S Woo, T West, E Powell, A Rimmer, C Orford, N Jones, J Williams, C I Bernal Matilla, P Ruiz de Gopegui Miguelena, P Sánchez Chueca, R Ramos Abril, M D C Rodríguez Longares, A L Ruíz Aguilar, R Garrido López de Murillas, R S Bourne, R Shulman, M Tomlin, G H Mills, M Borthwick, W Berry, D García Huertas, F Manzano, F Villagrán-Ramírez, A Ruiz-Perea, C Rodríguez-Mejías, F Santiago-Ruiz, M Colmenero-Ruiz, C König, B Matt, A Kortgen, C S Hartog, A Wong, C Balan, G Barker, N Srisawat, S Peerapornratana, P Laoveeravat, S Tachaboon, S Eiam-Ong, J Paratz, G Kayambu, R Boots, M F Aguilar Arzapalo, R Vlasenko, E Gromova, S Loginov, M Kiselevskiy, Y Dolgikova, K B Tang, C M Chau, K N Lam, E Gil, G Y Suh, C M Park, J Park, C R Chung, C T Lee, A Chao, P Y Shih, Y F Chang, C H Lai, Y C Hsu, Y C Yeh, Y J Cheng, V Colella, N Zarrillo, M D'Amico, F Forfori, B Pezza, T Laddomada, V Beltramelli, M L Pizzaballa, A Doronzio, B Balicco, D Kiers, W van der Heijden, J Gerretsen, Q de Mast, S El Messaoudi, G Rongen, M Gomes, M Kox, P Pickkers, N P Riksen, Y Kashiwagi, M Okada, K Hayashi, Y Inagaki, S Fujita, M N Nakamae, Y R Kang, R B Souza, A M A Liberatore, I H J Koh, A Blet, M Sadoune, J Lemarié, N Bihry, R Bern, E Polidano, R Merval, J M Launay, B Lévy, J L Samuel, A Mebazaa, J Hartmann, S Harm, V Weber
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27676533/p1-47-abound-sqm-qol-by-response-interim%C3%A2-analysis-of-squamous-nsclc-pts%C3%A2-treated-with-nab-paclitaxel-carboplatin-induction-therapy-track-advanced-nsclc
#13
Corey Langer, Vera Hirsh, Katayoun I Amiri, Amy Ko, Jeanna Knoble, Melissa Johnson, Robert Jotte, Michael Mccleod, Teng Jin Ong, Ray Page, David Spigel, Howard J West, Nataliya Trunova
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27616140/layer-by-layer-encapsulation-of-probiotics-for-delivery-to-the-microbiome
#14
Aaron C Anselmo, Kevin J McHugh, Jamie Webster, Robert Langer, Ana Jaklenec
The gastrointestinal (GI) microbiome has been widely investigated for its role in many diseases. However, technologies designed for microbiome delivery are lacking. Here, we report a layer-by-layer (LbL) approach for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines. These advantages translate to significantly enhanced survival of LbL-probiotics in vivo.
September 12, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27603781/endoscopic-lung-volume-reduction-using-endobronchial-valves-in-patients-with-severe-emphysema-and-very-low-fev1
#15
Franziska C Trudzinski, Anna J Höink, Daniela Leppert, Sebastian Fähndrich, Heinrike Wilkens, Thomas P Graeter, Frank Langer, Robert Bals, Peter Minko, Philipp M Lepper
BACKGROUND: Patients with a forced expiratory volume in 1 s (FEV1) below 20% of the predicted normal values (pred.) and either homogeneous emphysema or low diffusing capacity for carbon monoxide (DLCO) have a high risk for adverse events including death when undergoing surgical lung volume reduction. OBJECTIVES: We hypothesized that selected patients can benefit from endoscopic lung volume reduction (eLVR) despite a very low FEV1. METHODS: This study is a retrospective analysis of consecutive patients with severe airflow obstruction, an FEV1 ≤20% of pred...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27595237/interaction-between-integrin-%C3%AE-5-and-pde4d-regulates-endothelial-inflammatory-signalling
#16
Sanguk Yun, Madhusudhan Budatha, James E Dahlman, Brian G Coon, Ryan T Cameron, Robert Langer, Daniel G Anderson, George Baillie, Martin A Schwartz
Atherosclerosis is primarily a disease of lipid metabolism and inflammation; however, it is also closely associated with endothelial extracellular matrix (ECM) remodelling, with fibronectin accumulating in the laminin-collagen basement membrane. To investigate how fibronectin modulates inflammation in arteries, we replaced the cytoplasmic tail of the fibronectin receptor integrin α5 with that of the collagen/laminin receptor integrin α2. This chimaera suppressed inflammatory signalling in endothelial cells on fibronectin and in knock-in mice...
October 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27594517/a-size-selective-intracellular-delivery-platform
#17
May Tun Saung, Armon Sharei, Viktor A Adalsteinsson, Nahyun Cho, Tushar Kamath, Camilo Ruiz, Jesse Kirkpatrick, Nehal Patel, Mari Mino-Kenudson, Sarah P Thayer, Robert Langer, Klavs F Jensen, Andrew S Liss, J Christopher Love
Identifying and separating a subpopulation of cells from a heterogeneous mixture are essential elements of biological research. Current approaches require detailed knowledge of unique cell surface properties of the target cell population. A method is described that exploits size differences of cells to facilitate selective intracellular delivery using a high throughput microfluidic device. Cells traversing a constriction within this device undergo a transient disruption of the cell membrane that allows for cytoplasmic delivery of cargo...
September 4, 2016: Small
https://www.readbyqxmd.com/read/27583639/a-decade-of-progress-in-tissue-engineering
#18
Ali Khademhosseini, Robert Langer
Tremendous progress has been achieved in the field of tissue engineering in the past decade. Several major challenges laid down 10 years ago, have been studied, including renewable cell sources, biomaterials with tunable properties, mitigation of host responses, and vascularization. Here we review advancements in these areas and envision directions of further development.
October 2016: Nature Protocols
https://www.readbyqxmd.com/read/27570688/circumferential-optical-coherence-tomography-angiography-imaging-of-the-swine-esophagus-using-a-micromotor-balloon-catheter
#19
Hsiang-Chieh Lee, Osman Oguz Ahsen, Kaicheng Liang, Zhao Wang, Cody Cleveland, Lucas Booth, Benjamin Potsaid, Vijaysekhar Jayaraman, Alex E Cable, Hiroshi Mashimo, Robert Langer, Giovanni Traverso, James G Fujimoto
We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size...
August 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27534826/group-10-group-14-metal-complexes-e-tm-iv-the-role-of-the-group-14-site-as-an-l-x-and-z-type-ligand
#20
Erik Wächtler, Robert Gericke, Erica Brendler, Birgit Gerke, Thorsten Langer, Rainer Pöttgen, Lyuben Zhechkov, Thomas Heine, Jörg Wagler
A series of new complexes of a general motif [R2E(μ-N,S)2TM-L] (E: metalloid group 14 element; TM: group 10 metal; R: Cl, Ph, pyS, OH, (N,N,O)-chelating ligands; N,S: 1-methylimidazole-2-thiolate (methimazolyl, mt(-)), pyridine-2-thiolate (pyS(-)); L: PPh3, PCy3, pyS) was synthesised and characterised by single-crystal X-ray diffraction, multi-nuclear NMR spectroscopy ((1)H, (13)C, (31)P, (119)Sn), (119)Sn Mössbauer spectroscopy and quantum chemical calculations. The E-TM bonding situation in these compounds can be described with various resonance structures which comprise E(ii)→TM(ii), E(iii)-TM(i) and E(iv)←TM(0) features...
September 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
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