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https://www.readbyqxmd.com/read/29217251/effectiveness-and-safety-of-aprotinin-use-in-thoracic-aortic-surgery
#1
Pierpaolo Chivasso, Vito D Bruno, Roberto Marsico, Anilkumar Sankanahalli Annaiah, Alexander Curtis, Carlo Zebele, Gianni D Angelini, Alan J Bryan, Cha Rajakaruna
OBJECTIVE: To determine the effectiveness and safety of aprotinin use in adult patients undergoing thoracic aortic surgery. DESIGN: Single-center, retrospective study. SETTING: All cases performed at a single university hospital. PARTICIPANTS: Between January 2004 and December 2014, 846 adult patients underwent thoracic aortic surgery. Due to missing or duplicated data on primary outcomes, 314 patients were excluded...
June 23, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29215599/systematic-analysis-of-transcriptomic-profile-of-renal-cell-carcinoma-under-long-term-hypoxia-using-next-generation-sequencing-and-bioinformatics
#2
Szu-Chia Chen, Feng-Wei Chen, Ya-Ling Hsu, Po-Lin Kuo
Patients with clear cell renal cell carcinoma (ccRCC) are often diagnosed with both von Hippel-Lindau (VHL) mutations and the constitutive activation of hypoxia-inducible factor-dependent signaling. In this study, we investigated the effects of long-term hypoxia in 786-O, a VHL-defective renal cell carcinoma cell line, to identify potential genes and microRNAs associated with tumor malignancy. The transcriptomic profiles of 786-O under normoxia, short-term hypoxia and long-term hypoxia were analyzed using next-generation sequencing...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29215537/simultaneous-pancreas-and-kidney-transplantation-is-associated-with-inferior-long-term-outcomes-in-african-americans
#3
Joseph T Brooks, Rong Liu, Madeleine Oliver, Anthony DeLeonibus, Jingning Mei, Donald White, Eric Siskind, Jorge Ortiz
OBJECTIVES: Simultaneous pancreas and kidney transplant (SPK) is the most effective treatment for patients with type 1 diabetes mellitus and renal failure. However, the effect of ethnicity on SPK outcomes is not well understood. METHODS: We studied the influence of recipient ethnicity on SPK using the United Network for Organ Sharing database. A retrospective review of 20,196 SPK patients from 1989 to 2014 was performed. The recipients were divided into 4 groups: 15,833 whites (78...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215523/ethical-considerations-concerning-amnioinfusions-for-treating-fetal-bilateral-renal-agenesis
#4
Jeremy Sugarman, Jean Anderson, Ahmet A Baschat, Jaime Herrera Beutler, Jessica L Bienstock, Timothy E Bunchman, Niraj M Desai, Elena Gates, Aviva Goldberg, Paul C Grimm, Leslie Meltzer Henry, Eric B Jelin, Emily Johnson, Christine B Hertenstein, Anna C Mastroianni, Mark R Mercurio, Alicia Neu, Lawrence M Nogee, William J Polzin, Steven J Ralston, Ronald M Ramus, Megan Kasimatis Singleton, Michael J G Somers, Karen C Wang, Renee Boss
Congenital bilateral renal agenesis has been considered a uniformly fatal condition. However, the report of using serial amnioinfusions followed by the live birth in 2012 and ongoing survival of a child with bilateral renal agenesis has generated hope, but also considerable controversy over an array of complex clinical and ethical concerns. To assess the ethical concerns associated with using serial amnioinfusions for bilateral renal agenesis, we assembled a multidisciplinary group to map the ethical issues relevant to this novel intervention...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215520/preeclampsia-and-long-term-renal-function-in-women-who-underwent-kidney-transplantation
#5
Valerie Vannevel, Kathleen Claes, David Baud, Yvan Vial, Delaviz Golshayan, Eugene W Yoon, Ryan Hodges, Anne Le Nepveu, Peter G Kerr, Claire Kennedy, Mary Higgins, Elisabeth Resch, Philipp Klaritsch, Tim Van Mieghem
OBJECTIVE: Preeclampsia often complicates pregnancies after maternal kidney transplantation. We aimed to assess whether preeclampsia is associated with kidney function decline either during the pregnancy or in the long term. METHODS: We performed an international multicenter retrospective cohort study. Renal function at conception, pregnancy outcomes, and short- and long-term graft outcomes were collected for women who were pregnant after renal transplantation and had transplant and obstetric care at the participating centers...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29214442/shiga-toxin-triggers-endothelial-and-podocyte-injury-the-role-of-complement-activation
#6
REVIEW
Carlamaria Zoja, Simona Buelli, Marina Morigi
Shiga toxin (Stx)-producing Escherichia coli (STEC) is the offending agent in post-diarrhea-associated hemolytic uremic syndrome (HUS), a disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney failure, with thrombi occluding the renal microvasculature. Endothelial dysfunction has been recognized as the trigger event in the development of microangiopathic processes. Glomerular endothelial cells are susceptible to the toxic effects of Stxs that, via nuclear factor kappa B (NF-κB) activation, induce the expression of genes encoding for adhesion molecules and chemokines, culminating in leukocyte adhesion and platelet thrombus formation on the activated endothelium...
December 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29207950/persistent-hematuria-in-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis-during-clinical-remission-chronic-glomerular-lesion-or-low-grade-active-renal-vasculitis
#7
Li Lv, Dong-Yuan Chang, Zhi-Ying Li, Min Chen, Zhao Hu, Ming-Hui Zhao
BACKGROUND: Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. This study aimed to investigate the significance of persistent hematuria during clinical remission in a large cohort of AAV patients. METHODS: A cohort of 219 AAV patients in complete clinical remission after induction therapy at our center was retrospectively studied, and their clinical and laboratory data as well as long-term outcomes were analyzed...
December 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29207220/-long-term-outcome-of-renal-function-in-women-with-preeclampia-and-pregestational-diabetes
#8
REVIEW
Carmela Vadalà, Valeria Cernaro, Rossella Siligato, Roberta Granese, Antonio Simone Laganà, Michele Buemi, Domenico Santoro
Pre-eclampsia (PE) is an important cause of acute renal failure and an important risk marker for subsequent chronic kidney disease. In normal pregnancy, there are marked changes in the renin-angiotensin system (RAS) including considerably elevated angiotensin II (ang II) levels. However, vascular resistance decreases markedly during normal pregnancy, suggesting that pregnant individuals are less sensitive to ang II than non-pregnant individuals. In contrast, during PE decreased circulating components of the RAS with enhanced sensitivity of ang II infusion have been reported...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29206090/utility-of-serial-protocol-biopsies-performed-after-1-year-in-predicting-long-term-kidney-allograft-function-according-to-histologic-phenotype
#9
Mareena S Zachariah, Alok K Dwivedi, Cindy S Yip, Shirley S Chang, Aijaz Gundroo, Rocco C Venuto, John Tomaszewski, Sunil K Patel, Rajeev Sharma
OBJECTIVES: Prognostic implications of early protocol biopsies have been studied; however, the value of late protocol biopsy in predicting graft outcome has not been well defined. Here, we compared the effects of early and late protocol biopsy histologic findings in stable kidney allografts and aimed to understand the significance of "borderline" rejection on allograft function. MATERIALS AND METHODS: We studied 261 biopsies from 159 renal transplant recipients who were on a steroid-free, calcineurin inhibitor and mycophenolate mofetil regimen and who received transplants between 2004 and 2012 with mean follow-up of 5 years...
December 5, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29198657/association-of-brain-dead-donors-terminal-inflammation-with-delayed-graft-function-in-kidney-transplant-recipients
#10
D Cucchiari, J Rovira, D Paredes, P Ventura-Aguiar, A Sanchez-Escuredo, M Solé, R Adalia, F Oppenheimer, F Diekmann, I Revuelta
BACKGROUND: Systemic inflammation affects kidney function in a wide range of diseases. Even in kidney transplant recipients, higher levels of C-reactive protein (CRP) are invariably associated with both worse short- and long-term graft outcomes. However, little is known about systemic inflammation in kidney donors and, notably, brain death causes a strong systemic inflammatory response. OBJECTIVE: To analyze the role of systemic inflammation of brain-dead donors on short-term kidney graft outcomes (ie, delayed graft function [DGF], defined as the need of dialysis during the first week after transplantation)...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198641/hemodialysis-self-management-intervention-randomized-trial-hed-smart-a-practical-low-intensity-intervention-to-improve-adherence-and-clinical-markers-in-patients-receiving-hemodialysis
#11
Konstadina Griva, Mooppil Nandakumar, Jo-An H Ng, Kevin F Y Lam, Hayley McBain, Stanton P Newman
BACKGROUND: Poor adherence to treatment is common in hemodialysis patients. However, effective interventions for adherence in this population are lacking. Small studies of behavioral interventions have yielded improvements, but clinical effectiveness and long-term effects are unclear. STUDY DESIGN: Multicenter parallel (1:1) design, blinded cluster-randomized controlled trial. SETTING & PARTICIPANTS: Patients undergoing maintenance hemodialysis enrolled in 14 dialysis centers...
November 30, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29197971/comparison-of-long-term-follow-up-outcomes-between-multiple-drugs-combination-therapy-and-tonsillectomy-pulse-therapy-for-pediatric-iga-nephropathy
#12
Yukihiko Kawasaki, Ryo Maeda, Syuto Kanno, Yuichi Suzuki, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya
BACKGROUND: To clarify the long-term efficacy of multiple-drugs combination therapy (PWDM) and tonsillectomy pulse therapy (TPT) for pediatric IgA nephropathy (IgAN), we retrospectively evaluated the clinical and laboratory findings as well as the prognosis for IgAN patients treated with each treatment at long-term follow-up. METHODS: We collected data on 61 children who had been diagnosed with severe IgAN. The children were retrospectively divided into two groups...
December 2, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29197145/long-term-follow-up-of-ribavirin-free-daa-based-treatment-in-hcv-recurrence-after-orthotopic-liver-transplantation
#13
Sandra Beinhardt, Ramona Al-Zoairy, Karin Kozbial, Albert Friedrich Stättermayer, Andreas Maieron, Rudolf Stauber, Michael Strasser, Heinz Zoller, Ivo Graziadei, Susanne Rasoul-Rockenschaub, Michael Trauner, Peter Ferenci, Harald Hofer
BACKGROUND & AIMS: Excellent efficacy and safety-profile of second generation DAA-combinations improved treatment of chronic hepatitis C (HCV) as well as in HCV-recurrence after orthothopic liver transplantation (OLT). The need of ribavirin-addition is under debate as anemia and decreased renal function are prevalent in transplant-cohorts. Aim of this study was thus to assess safety and long-term efficacy of RBV-free DAA-combinations in HCV-recurrent patients after OLT. PATIENTS & METHODS: 62 OLT-recipients (male:50/81%; age:60...
December 2, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29196613/protective-effect-of-luteolin-against-renal-ischemia-reperfusion-injury-via-modulation-of-pro-inflammatory-cytokines-oxidative-stress-and-apoptosis-for-possible-benefit-in-kidney-transplant
#14
Yan Liu, Baoxin Shi, Yi Li, Hui Zhang
BACKGROUND The acceptances and long-term outcomes of the renal transplantations are seriously jeopardized by inflammatory responses and damage to tissues. The present study intended to explicate the pharmacological effect of luteolin (LT) in renal ischemia/reperfusion (I/R) injury and the possible mechanism of action of LT. MATERIAL AND METHODS The effect of LT on the level of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the homogenates of kidney tissues of male Swiss albino mice was determined after I/R injury...
December 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29196304/long-term-clinical-outcomes-after-early-initiation-of-rrt-in-critically-ill-patients-with-aki
#15
Melanie Meersch, Mira Küllmar, Christoph Schmidt, Joachim Gerss, Toni Weinhage, Andreas Margraf, Thomas Ermert, John A Kellum, Alexander Zarbock
Whether earlier initiation of RRT in critically ill patients with AKI can improve outcomes remains debated. We examined follow-up data from a large clinical trial to prospectively investigate the long-term outcomes associated with the timing of RRT initiation in such patients. We extended the follow-up of patients in the Early Versus Delayed Initiation of RRT in Critically Ill Patients with AKI (ELAIN) Trial from 90 days to 1 year after randomization for 230 (99.6%) patients. The primary outcome was a composite of major adverse kidney events (persistent renal dysfunction, dialysis dependence, and mortality) at 1 year...
December 1, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29194767/evolution-of-lung-and-kidney-allograft-function-in-patients-receiving-kidney-after-lung-transplantation
#16
Nina T Weber, Marco Bonani, Christian Benden, Andreas Schleich, Thomas Fehr, Thomas F Mueller, Macé M Schuurmans
Calcineurin inhibitor (CNI) toxicity leads to ESRD in almost half of long-term survivors after lung transplantation, some of them receiving kidney transplants. Little is known about the outcomes of kidney and lung allograft function following kidney after lung transplantation (KALTPL) in the modern era. We retrospectively analyzed a group of 13 consecutive patients who received a KALTPL with respect to their renal and pulmonary function and immunological evolution over 2 years. We documented a stable evolution of forced expiratory volume in one second (FEV1) after KALTPL in most patients as well as an excellent kidney graft during the 2-year follow-up period...
December 1, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29192802/adhering-to-the-principles-of-clinical-pharmacology-the-correct-fixed-combinations-of-antihypertensive-drugs
#17
Lopatowska Paulina, Mlodawska Elzbieta, Tomaszuk-Kazberuk Anna, Maciej Banach, Malyszko Jolanta
Introduction Hypertension is one of the primary modifiable risk factors for cardiac and renal diseases. The prevalence of hypertension appears to be around 30-45% of the general population, with a steep increase with ageing. The administration of blood pressure-lowering drugs is to reduce the risk of major clinical cardiovascular outcomes: stroke, myocardial infarction, heart failure and cardiovascular deaths. Hypertension guidelines recommend combination therapy in patients with high cardiovascular risk and with subclinical organ damage as well as when monotherapy fails...
December 1, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29191961/intragraft-molecular-pathways-associated-with-tolerance-induction-in-renal-transplantation
#18
Lorenzo Gallon, James M Mathew, Sai Vineela Bontha, Catherine I Dumur, Pranav Dalal, Lakshmi Nadimpalli, Daniel G Maluf, Aneesha A Shetty, Suzanne T Ildstad, Joseph R Leventhal, Valeria R Mas
The modern immunosuppression regimen has greatly improved short-term allograft outcomes but not long-term allograft survival. Complications associated with immunosuppression, specifically nephrotoxicity and infection risk, significantly affect graft and patient survival. Inducing and understanding pathways underlying clinical tolerance after transplantation are, therefore, necessary. We previously showed full donor chimerism and immunosuppression withdrawal in highly mismatched allograft recipients using a bioengineered stem cell product (FCRx)...
November 30, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29191630/efficacy-and-safety-of-bivalirudin-in-coronary-artery-disease-patients-with-mild-to-moderate-chronic-kidney-disease-meta-analysis
#19
Xiaofang Zeng, A Michael Lincoff, Stefanie Schulz-Schüpke, Philippe Gabriel Steg, Yedid Elbez, Roxana Mehran, Gregg W Stone, Thomas McAndrew, Jianhui Lin, Xindan Zhang, Wenhai Shi, Han Lei, Zhicheng Jing, Wei Huang
BACKGROUND: Patients with chronic kidney disease (CKD) have elevated bleeding and ischemic outcomes. We aim to assess the short- and long-term efficacy and safety of bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPIs) in coronary artery disease (CAD) patients with CKD. METHODS: Randomized trials were searched in PubMed, Cochrane, and Embase databases up to January 2017. Among the trials retrieved, efficacy endpoints were defined as mortality, myocardial infarction (MI), repeat revascularization, stent thrombosis, and major adverse cardiac events (MACEs)...
November 27, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29190861/-outcome-of-acute-kidney-injury-in-critically-ill-patients-treated-with-intermittent-hemodialysis-versus-crrt
#20
Mariana Ávalos-López, María Juana Pérez-López, Carolina Aguilar-Martínez, Ana María Del Carmen Díaz-Franco, Alejandro Esquivel-Chávez, José Angel Baltazar-Torres
BACKGROUND: Acute kidney injury (AKI) is common in critically ill patients and it is associated with poor outcome. Some patients require renal replacement therapy (RRT), and the most frequently used are intermittent hemodialysis (IHD) and continuous renal replacement therapies (CRRT). Current evidence is insufficient to conclude which modality is most appropriate to treat critically ill patients with AKI. METHODS: We reviewed the clinical records of critically ill patients with stage 3 AKI treated with RRT...
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
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