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bilateral carotide artery stenosis

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https://www.readbyqxmd.com/read/29434750/comparative-analysis-of-3d-time-resolved-contrast-enhanced-magnetic-resonance-angiography-color-doppler-ultrasound-and-digital-subtraction-angiography-in-symptomatic-carotid-stenosis
#1
Hongkai Cui, Ruifang Yan, Zhansheng Zhai, Jipeng Ren, Zheng Li, Qiang Li, Shouying Wang
The present study aimed to compare the diagnostic value of contrast-enhanced magnetic resonance angiography (CE MRA) with 3D time-resolved imaging of contrast kinetics, color Doppler ultrasound (CDUS) and digital subtraction angiography (DSA) in extracranial carotid stenosis (CS). A total of 54 patients with symptomatic CS were subjected to CDUS, CE MRA and DSA examination. Results of DSA were defined as the standard, and a total of 216 vessels were examined. In each patient four vessels were examined, namely the bilateral common carotid arteries and the bilateral internal carotid arteries...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29431106/beneficial-effect-of-mas-receptor-deficiency-on-vascular-cognitive-impairment-in-the-presence-of-angiotensin-ii-type-2-receptor
#2
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan-No, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi
BACKGROUND: The classical renin-angiotensin system is known as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. The angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis is known to exert antagonistic actions against the classical renin-angiotensin system axis in the cardiovascular system. However, its roles in the brain remain unclear. We examined possible roles of the angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis in cognitive function, employing vascular cognitive impairment model mice...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29424477/association-of-lipoprotein-associated-phospholipase-a2-mass-with-asymptomatic-cerebral-artery-stenosis
#3
Youxin Wang, Bin Zhou, Pingan Zhou, Yan Yao, Qinghua Cui, Yingping Liu, Jichun Yang, Shouling Wu, Xingquan Zhao, Yong Zhou
Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010-2011 to investigate whether Lp-PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS)...
February 9, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29415035/predicting-outcome-of-morris-water-maze-test-in-vascular-dementia-mouse-model-with-deep-learning
#4
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Harumi Kan-No, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi
The Morris water maze test (MWM) is one of the most popular and established behavioral tests to evaluate rodents' spatial learning ability. The conventional training period is around 5 days, but there is no clear evidence or guidelines about the appropriate duration. In many cases, the final outcome of the MWM seems predicable from previous data and their trend. So, we assumed that if we can predict the final result with high accuracy, the experimental period could be shortened and the burden on testers reduced...
2018: PloS One
https://www.readbyqxmd.com/read/29395638/lenalidomide-induced-ischemic-cerebrovascular-disease-in-polyneuropathy-organomegaly-endocrinopathy-monoclonal-gammopathy-and-skin-changes-syndrome
#5
Akihiko Mitsutake, Hideyuki Matsumoto, Keiko Hatano, Koreaki Irie, Nobuhiro Tsukada, Hideji Hashida
We describe the case of a 34-year-old woman with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. She developed transient ischemic attack after the introduction of lenalidomide plus dexamethasone (Rd) therapy despite no vascular risk factors. Magnetic resonance and computed tomography angiographies showed bilateral internal carotid artery stenosis. Rd therapy was suspended because of its thromboembolic risk. She had been neurologically stable during the suspension of Rd therapy...
January 29, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29379567/rare-presentation-of-moyamoya-disease-with-sub-acute-presentation-in-iran
#6
Payam Sasannejad, Fateme Rezaei, Reza Bidaki, Ehsan Zarepur
Moyamoya disease is a chronic progressive vascular disease of brain characterized by bilateral stenosis or occlusion of the arteries around the circle of Willis with prominent arterial collateral circulation. We introduce here a patient with Moyamoya who was misdiagnosed. She was a 16-yr-old female from north east of Iran who complained left hemiparesis and was diagnosed Moyamoya disease by brain and cervical CT-Angiography. There was still great difficulty in the diagnosis of diffuse white matter lesions. The CT-Angiography showed bilateral internal carotid stenosis with "puff of smoke" collateralization arising from the circle of Willis, therefore Moyamoya disease was raised...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29362286/-bilateral-internal-carotid-artery-dissection-caused-by-elongated-styloid-processes-a-case-report
#7
Toru Takino, Satoshi Shibuma, Yu Kanemaru, Koji Okamura, Aki Oshima, Manami Tazawa, Takeo Nashimoto, Naoto Tsuchiya, Junichi Yoshimura, Kiminori Netsu, Takafumi Saito
We report a case of bilateral internal carotid artery(ICA)dissection associated with bilateral elongated styloid processes(ESPs). A 46-year-old man presented with transient aphasia and left visual disturbance at a business meeting. He complained of a foreign body sensation in his throat during swallowing for two years. Magnetic resonance imaging(MRI)demonstrated fresh small infarcts in the left corona radiata. Magnetic resonance angiography(MRA)revealed string signs bilaterally in the cervical ICAs. The patient was diagnosed with bilateral idiopathic ICA dissection and was treated with ozagrel and clopidogrel...
January 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29337010/protective-effects-of-a-radical-scavenger-edaravone-on-oligodendrocyte-precursor-cells-against-oxidative-stress
#8
Hajime Takase, Anna C Liang, Nobukazu Miyamoto, Gen Hamanaka, Ryo Ohtomo, Takakuni Maki, Loc-Duyen D Pham, Josephine Lok, Eng H Lo, Ken Arai
Oligodendrocyte precursor cells (OPCs) play critical roles in maintaining the number of oligodendrocytes in white matter. Previously, we have shown that oxidative stress dampens oligodendrocyte regeneration after white matter damage, while a clinically proven radical scavenger, edaravone, supports oligodendrocyte repopulation. However, it is not known how edaravone exerts this beneficial effect against oxidative stress. Using in vivo and in vitro experiments, we have examined whether edaravone exhibits direct OPC-protective effects...
January 11, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29289952/transcarotid-transcatheter-aortic-valve-replacement-as-preferred-alternative-access-in-a-patient-with-bilateral-carotid-artery-disease
#9
Puja B Parikh, Shang Loh, Luis Gruberg, Neal Patel, Jonathan Weinstein, Henry Tannous, Thomas Bilfinger
A 78-year-old man presented with severe symptomatic aortic stenosis and a heavily calcified, stenotic aortic valve. Given multiple comorbidities, the heart team agreed on a transcatheter approach via the left common carotid artery.
January 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29286024/-subclavian-carotid-replacement-in-chronic-cerebrovascular-insufficiency-management
#10
A B Stepanenko, E R Charchyan, A P Gens, S V Fedulova, M N Seleznev, P N Shvedov
AIM: To present own experience of subclavian-carotid replacement for chronic cerebrovascular insufficiency management. MATERIAL AND METHODS: For 12 years 7 subclavian-carotid reconstructions were performed that was 1.2% of all carotid repairs during this period. Great saphenous vein was always used as a graft. Carotid endarterectomy from proximal internal carotid artery was additionally performed if it was necessary. Patients had severe advanced lesion of supra-aortic vessels including bilateral carotid lesion and significant stenosis of ipsilateral proximal common carotid artery...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29273593/novel-susceptibility-loci-for-moyamoya-disease-revealed-by-a-genome-wide-association-study
#11
Lian Duan, Ling Wei, Yanghua Tian, Zhengshan Zhang, Panpan Hu, Qiang Wei, Sugang Liu, Jun Zhang, Yuyang Wang, Desheng Li, Weizhong Yang, Rui Zong, Peng Xian, Cong Han, Xiangyang Bao, Feng Zhao, Jie Feng, Wei Liu, Wuchun Cao, Guoping Zhou, Chunyan Zhu, Fengqiong Yu, Weimin Yang, Yu Meng, Jingye Wang, Xianwen Chen, Yu Wang, Bing Shen, Bing Zhao, Jinghai Wan, Fengyu Zhang, Gang Zhao, Aimin Xu, Xuejun Zhang, Jianjun Liu, Xianbo Zuo, Kai Wang
BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a rare cerebral vasculopathy characterized by bilateral internal carotid artery stenosis and often leads to stroke in children or young adults. Although familial inheritance is well recognized, the genetic basis of MMD remains poorly understood. METHODS: A 2-stage genome-wide association study was conducted involving 1492 cases and 5084 controls. In the discovery stage, logistic regression was used to test associations, and imputation was conducted based on genotyped single-nucleotide polymorphisms (SNPs)...
January 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29260015/evolution-into-moyamoya-disease-in-an-infant-with-internal-carotid-artery-aneurysms
#12
Ryosuke Tanaka, Satoru Takahashi, Satomi Okano, Akie Okayama, Nao Suzuki, Shigeo Kure, Hiroshi Azuma
Introduction: Moyamoya disease (MMD) is characterized by progressive stenosis and occlusion in the terminal portion of both internal carotid arteries (ICAs) and the formation of an abnormal vascular network. Because of the fragile structure of the collateral vessels, MMD is frequently accompanied by intracranial aneurysms that are mainly located within the abnormal basal network or the circle of Willis. However, the association between MMD and aneurysms of the ICAs has never been reported previously...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29240808/altered-cerebral-hemodyamics-and-cortical-thinning-in-asymptomatic-carotid-artery-stenosis
#13
Randolph S Marshall, Iris Asllani, Marykay A Pavol, Ying-Kuen Cheung, Ronald M Lazar
Cortical thinning is a potentially important biomarker, but the pathophysiology in cerebrovascular disease is unknown. We investigated the association between regional cortical blood flow and regional cortical thickness in patients with asymptomatic unilateral high-grade internal carotid artery disease without stroke. Twenty-nine patients underwent high resolution anatomical and single-delay, pseudocontinuous arterial spin labeling magnetic resonance imaging with partial volume correction to assess gray matter baseline flow...
2017: PloS One
https://www.readbyqxmd.com/read/29218106/extracorporeal-shock-wave-therapy-effectively-protects-brain-against-chronic-cerebral-hypo-perfusion-induced-neuropathological-changes
#14
Han-Tan Chai, Kuan-Hung Chen, Christopher Glenn Wallace, Chih-Hung Chen, Pei-Hsun Sung, Yung-Lung Chen, Chun-Man Yuen, Pei-Lin Shao, Cheuk-Kwan Sun, Hsueh-Wen Chang, Ching-Jen Wang, Mel S Lee, Hon-Kan Yip, Sheung-Fat Ko
This study tested the hypothesis that extracorporeal shock wave (ECSW) therapy could protect mouse brain from chronic cerebral hypoperfusion (CHP)-induced neuropathological changes in a bilateral carotid arterial stenosis (CAS) model. Adult-male C57BL/6 (B6) mice (n=36) were randomized into group 1 (sham-control), group 2 (CHP) and group 3 [CHP+ECSW (100 impulses at 0.15 mJ/mm2) on day 5, 10 and 15 after CHP induction]. By day 60 after CHP induction, the white matter lesion, protein expressions of inflammatory (TNF-α/NF-κB/iNOS), oxidative-stress (NOX-1/NOX-2/NOX-4/nitrotyrosine), angiogenesis (eNOS/CD31), apoptotic (Bax/caspase-3/PARP), fibrotic (Smad3/TGF-ß) and mitochondrial-damaged (cytosolic cytochrome-C) biomarkers were significantly higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1, whereas the protein expressions of anti-apoptotic (Bcl-2), anti-fibrotic (BMP-2/Smad1/5), and mitochondrial-integrity (mitochondrial cytochrome-C) biomarkers showed an opposite pattern to inflammation among the three groups (all P<0...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217363/positional-brain-single-photon-emission-computed-tomography-findings-in-a-case-of-limb-shaking-syndrome
#15
Caroline Bund, Céline Heimburger, Valérie Wolff, Izzie Jacques Namer
An 84-year-old man, who presented lower limbs limb-shaking syndrome at orthostatism lasting a few seconds, was referred in our stroke unit. Magnetic resonance imaging showed an acute infarction in the right thalamus and the insular cortex, left extracranial carotid stenosis at 80%, and low flow in the right middle cerebral artery but did not explain limb-shaking syndrome symptomatology. We performed comparative positional brain perfusion single-photon emission computed tomography (SPECT), in the upright and in the supine position, to explore and localize hypoperfusion-endangered brain structures that may be involved in the presenting symptoms...
December 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29192539/experimental-chronic-cerebral-hypoperfusion-results-in-decreased-pericyte-coverage-and-increased-blood-brain-barrier-permeability-in-the-corpus-callosum
#16
Qinghai Liu, Ryan Radwanski, Robin Babadjouni, Arati Patel, Drew M Hodis, Peter Baumbacher, Zhen Zhao, Berislav Zlokovic, William J Mack
Murine chronic cerebral hypoperfusion (CCH) results in white matter (WM) injury and behavioral deficits. Pericytes influence blood-brain barrier (BBB) integrity and cerebral blood flow. Under hypoxic conditions, pericytes detach from perivascular locations increasing vessel permeability and neuronal injury. This study characterizes the time course of BBB dysfunction and pericyte coverage following murine experimental CCH secondary to bilateral carotid artery stenosis (BCAS). Mice underwent BCAS or sham operation...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29169797/carotid-artery-disease-as-a-predictor-of-in-hospital-postoperative-stroke-after-coronary-artery-bypass-grafting-from-1999-to-2011
#17
Amol Mehta, Ravi Choxi, Thomas Gleason, Lawrence Wechsler, Tudor Jovin, Parthasarathy D Thirumala
BACKGROUND: In this study, the risk factors for stroke after coronary artery bypass grafting (CABG) were examined. In particular, the role of asymptomatic carotid artery stenosis (both unilateral and bilateral) as a predictor of in-hospital postoperative stroke was investigated. Finally, the trends surrounding in-hospital postoperative stroke from 1999 to 2011 also were examined. The purpose of the study was to appropriately identify patients at high risk for stroke after CABG and spark discussion about the perioperative management of such patients...
October 9, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29131102/a-case-of-a-4-year-old-female-with-a-primary-spinal-malignancy-presenting-with-froin-s-syndrome
#18
Andrew T Hale, Gregory P Fricker, Travis W Crook
We report the case of a 4-year-old female with a primary extradural intramedullary atypical teratoid/rhabdoid tumor (AT/RT) leading to a middle cerebral artery (MCA) infarct and Froin's syndrome. She presented with a 6-pound weight loss over the previous week, as well as a decreased urinary output and an altered mental status. She underwent a brain MRI that revealed a left MCA infarct, mild ventriculomegaly, and bilateral internal carotid artery, M1, and A1 stenosis. An external ventricular drain (EVD) was placed due to increased intracranial pressure...
2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29114096/fingolimod-protects-against-ischemic-white-matter-damage-by-modulating-microglia-toward-m2-polarization-via-stat3-pathway
#19
Chuan Qin, Wen-Hui Fan, Qian Liu, Ke Shang, Madhuvika Murugan, Long-Jun Wu, Wei Wang, Dai-Shi Tian
BACKGROUND AND PURPOSE: White matter (WM) ischemic injury, a major neuropathological feature of cerebral small vessel diseases, is an important cause of vascular cognitive impairment in later life. The pathogenesis of demyelination after WM ischemic damage are often accompanied by microglial activation. Fingolimod (FTY720) was approved for the treatment of multiple sclerosis for its immunosuppression property. In this study, we evaluated the neuroprotective potential of FTY720 in a WM ischemia model...
November 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29103477/atherosclerotic-plaque-features-and-distribution-in-bilateral-carotid-arteries-of-asymptomatic-elderly-population-a-3d-multicontrast-mr-vessel-wall-imaging-study
#20
Ying Cai, Le He, Chun Yuan, Huijun Chen, Qiang Zhang, Rui Li, Cheng Li, Xihai Zhao
PURPOSE: This study sought to investigate the characteristics of morphology, compositions and distribution of carotid atherosclerotic plaques in asymptomatic elderly population using three dimensional (3D) multicontrast magnetic resonance vessel wall imaging. MATERIALS AND METHODS: 146 asymptomatic elderly subjects (≥60years) were recruited and underwent 3D multicontrast MR vessel wall imaging for bilateral carotid arteries on a 3.0T MR scanner. The presence of carotid atherosclerotic plaque was determined and the stenosis was measured...
November 2017: European Journal of Radiology
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