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Neutropenic diet

Lars Tramsen, Emilia Salzmann-Manrique, Konrad Bochennek, Thomas Klingebiel, Dirk Reinhardt, Ursula Creutzig, Lillian Sung, Thomas Lehrnbecher
PURPOSE: Although nonpharmacologic anti-infective measures are widely used in children treated for acute myeloid leukemia (AML), there is little evidence of their effectiveness. PATIENTS AND METHODS: We analyzed infectious complications in children during intensive treatment of AML according to the AML-BFM 2004 trial and surveyed sites on institutional standards regarding recommended restrictions of social contacts (six items), pets (five items), and food (eight items)...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Mohamad Bassam Sonbol, Belal Firwana, Maria Diab, Ahmad Zarzour, Thomas E Witzig
Neutropenic diets (ND) are often prescribed to cancer patients aiming to reduce infection risk. The goal of this meta-analysis was to determine if ND indeed reduced the risk of infection and death in cancer patients compared to regular diets (RD). We identified studies in cancer patients that compared the effect of ND vs. RD on the risk of infections and mortality of any cause. The overall effect was calculated by use of a random effects model. Four studies were identified encompassing 918 patients. There was no difference in major infection or mortality rates between ND and RD groups...
2015: Nutrition and Cancer
Martha Lassiter, Susan M Schneider
BACKGROUND: Historically, dietary restrictions imposed on patients undergoing hematopoietic stem cell transplantation (HSCT) were severe and limited to prevent exposure to foodborne organisms. With improvements in supportive care and anti-infective agents, the necessity of the neutropenic diet for this population has been in question. OBJECTIVES: This study aimed to determine whether the incidence of infection differs and to analyze the nutritional status in patients undergoing myeloablative allogeneic HSCT with a neutropenic diet as compared to those with a diet without restrictions...
June 2015: Clinical Journal of Oncology Nursing
S E Carr, V Halliday
BACKGROUND: Patients with chemotherapy-induced neutropenia are at increased risk of infection. Historically, dietary restrictions commonly referred to as 'clean', 'low bacteria', 'low-microbial' or 'neutropenic' diets have been prescribed to reduce the risk of foodborne infection. Although research does not support their effectiveness, they continue to be used in clinical practice. The present study aimed to investigate the use of dietary restrictions in patients with cancer in the UK by surveying registered dietitians (RDs)...
October 2015: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
Lauren E Braun, Heidi Chen, Haydar Frangoul
BACKGROUND: The role of the neutropenic diet in the development of infections in oncology and stem cell transplant (SCT) patients is controversial. There is no data on the use of the neutropenic diet among pediatric oncologists. METHODS: A self-administered electronic survey was sent to 1,639 pediatric oncologists at 198 institutions who are members of Children's Oncology Group. A pediatric dietitian and pediatric oncologists developed, pretested, and modified the survey for item clarification...
October 2014: Pediatric Blood & Cancer
Melissa Foster
The neutropenic diet historically has been a mainstay in oncology practice, with many providers continuing to adhere tightly to the diet for patients with neutropenia. However, clinically sound evidence remains limited and weak and does not support the diet as a foundation for policy and practice. Therefore, two questions remain: Does evidence exist to support the effectiveness of the neutropenic diet in reducing infection rates in the neutropenic oncology population? Based on limited evidence supporting the neutropenic diet in this population, what clinically sound diet strategies are best for these patients?...
April 2014: Clinical Journal of Oncology Nursing
Paula Cristina Galati, Renata Cristina Lataro, Vanessa Maciel Souza, Elaine Cristina Pereira de Martinis, Paula Garcia Chiarello
OBJECTIVE: This study aimed to analyze and compare the microbiological profile and vitamin C content of raw and cooked foods destined for neutropenic inpatients. METHODS: Three vegetables and nine fruits, raw and boiled, washed and sanitized were examined. Heat-tolerant coliforms and coagulase-positive staphylococci were counted and the presence of Salmonella spp was investigated. The vitamin C content was analyzed by a colorimetric reaction. The Statistical Package for Social Sciences (SPSS) software was used for statistical analysis and the nonparametric Wilcoxon test was used to compare the mean vitamin C values of the cooked and raw foods...
2013: Revista Brasileira de Hematologia e Hemoterapia
Adriana Garófolo
No abstract text is available yet for this article.
2013: Revista Brasileira de Hematologia e Hemoterapia
Walid Rasheed, Ardeshir Ghavamzadeh, Rosemarie Hamladji, Tarek Ben Othman, Amal Alseraihy, Fawzi Abdel-Rahman, Alaa Elhaddad, Abdulaziz Alabdulaaly, David Dennison, Ahmad Ibrahim, Ali Bazarbachi, Mohamed-Amine Bekadja, Said Yousuf Mohamed, Salman Naseem Adil, Parvez Ahmed, Said Benchekroun, Mani Ramzi, Mohammad Jarrar, Kamran Alimoghaddam, Fazal Hussain, Amir Hamidieh, Mahmoud Aljurf
INTRODUCTION: This practice survey is conducted to analyze clinical hematopoietic stem cell transplantation (HSCT) practice variability among centers in the WHO Eastern Mediterranean Region (EMRO), as represented by the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) group. METHOD: This internet based survey was completed by the medical program directors of the EMBMT centers; 17 centers participated. The survey collected data on various clinical aspects of HSCT practice...
March 2013: Hematology/oncology and Stem Cell Therapy
Mi Ra Rho, Jeong Hyun Lim, Jung Hwa Park, Seung Seok Han, Yon Su Kim, Young Hee Lee, Won Gyoung Kim
The purpose of our study was to evaluate the dietary intake of kidney transplant recipients (KTRs) and assess oral intake related nutrition problems. Fifty patients who had undergone kidney transplantation were included: 24 males, 26 females. The mean age was 46.8 ± 11.2 years, height was 161.3 ± 8.3 cm, and body weight was 60.5 ± 8.7 kg. We conducted nutrition education based on the diet guideline for KTRs (energy 32 kcal/kg of ideal body weight [IBW], protein 1.3 g/kg of IBW) and neutropenic diet guideline before discharge...
January 2013: Clinical Nutrition Research
Steven M Trifilio, Judy Pi, Jayesh Mehta
The incidence and severity of Clostridium difficile-associated disease (CDAD) within the general population has risen dramatically over the past decade, yet little data are available from hematopoietic stem cell transplantation (HSCT) centers. In the present study, we performed a chart review of 822 consecutive autologous and allogeneic HCST recipients treated at Northwestern Memorial Hospital between 2004 and 2008 to determine the incidence of CDAD at our institution. Variables including age, sex, diagnosis, chemotherapy regimen, transplantation type, microbial colonization, coinfections, diet, antibiotic use, neutropenic fever, comorbid conditions, time to engraftment, growth factor administration, and occurrence of graft-versus-host disease were assessed as potential risk factors for the development of CDAD...
March 2013: Biology of Blood and Marrow Transplantation
Silvia Maria Albertini
No abstract text is available yet for this article.
2012: Revista Brasileira de Hematologia e Hemoterapia
Catherine C Aftandilian, Casey Milotich, Kathleen M Sakamoto
No abstract text is available yet for this article.
June 2012: Oncology (Williston Park, NY)
Nicole Fox, Alison G Freifeld
For decades, the concept of a neutropenic diet has implied a strict limitation of foods allowed for consumption, as a presumptive means of reducing the risk of infection in cancer patients. The rationale was to limit the introduction of potentially harmful bacteria into the gastrointestinal tract by the restriction of certain foods that might harbor those organisms. However, this concept has not been substantiated with direct proof, and no universal definition of the neutropenic diet exists. Exactly which foods are restricted varies greatly by institution, but most notable is the restriction of fresh fruits and vegetables...
June 2012: Oncology (Williston Park, NY)
Michael Boeckh
No abstract text is available yet for this article.
September 2012: Biology of Blood and Marrow Transplantation
Steven Trifilio, Irene Helenowski, Meghan Giel, Barbara Gobel, Judy Pi, Deborah Greenberg, Jayesh Mehta
The use of a neutropenic diet (ND) after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago as a means of preventing infection from organisms colonizing the gastrointestinal tract. Evidence supporting this practice is lacking, however, and the actual efficacy of the ND remains unknown. Institutional policy at Northwestern Memorial Hospital discontinued the use of ND in 2006. We conducted a retrospective study of 726 consecutive HSCT recipients, 363 who received an ND and 363 who received a general hospital diet, to determine the incidence of microbiologically confirmed infections during and after transplantation...
September 2012: Biology of Blood and Marrow Transplantation
T Mutel, J Foeglé, L Belotti, V Sery, O Bourneton, C Hernandez, P Lutz, T Lavigne
OBJECTIVE: This article clarifies the choices made by the HUS concerning the ways of preparing food reserved to neutropenic children hospitalized in pediatric oncology service. We will describe the results of microbiological analysis of food realized from 2002 to 2007. METHODS: A specific team prepares this food which is canned and treated by "appertisation" (autoclaving). Each dish portion produced is provided to the service only if the microbiological results are conform, that is to say free of organisms...
December 2012: Pathologie-biologie
Steven J Jubelirer
There really should not be a debate about the use of neutropenic diet for cancer patients. Its usefulness has never been scientifically proven. However, neutropenic diets remain in place in many institutions even though their usefulness is controversial. Neutropenic diets were once thought to be important in protecting patients from having to succumb to infection from neutropenia while undergoing chemotherapy. Although food may contain harmful organisms and research has shown that bacterial translocation is possible, recent studies have been unable to obtain significant differences between placebo and intervention groups...
2011: Oncologist
Maik Drechsler, Remco T A Megens, Marc van Zandvoort, Christian Weber, Oliver Soehnlein
BACKGROUND: Inflammation and activation of immune cells are key mechanisms in the development of atherosclerosis. Previous data indicate important roles for monocytes and T lymphocytes in lesion formation, whereas the contribution of neutrophils remains to be firmly established. Here, we investigate the effect of hypercholesterolemia on peripheral neutrophil counts, neutrophil recruitment to atherosclerotic lesions, and the importance of neutrophils in atherosclerotic lesion formation in Apoe(-/-) mice...
November 2, 2010: Circulation
Elihu Estey
Older patients are generally, and arbitrarily, defined as those aged 60 and above. It is important to recognise that the effect of age is modulated by numerous other prognostic factors such as performance status, presence of various co-morbidities, and most importantly, cytogenetics. It is generally acknowledged that survival has not improved in a medically significant fashion for older patients. Nonetheless, there has been some progress. Specific improvements include the availability of new therapies, including reduced intensity allogeneic haematopoietic stem cell transplant; the subdivision of the resistant response category into subcategories, such as complete response with incomplete platelet recovery (CRp); the introduction of selection designs prior to initiating large phase 3 trials; the departure from the view that all older patients are the same and are, for example, necessarily candidates for trials of new drugs; increased awareness of the effect of selection bias; and increased questioning of certain practices, such as the imposition of a neutropenic diet, and recommendations to wear masks or avoid crowds...
December 2009: Best Practice & Research. Clinical Haematology
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