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REVIEW
Laura Pedretti, Davide Leardini, Edoardo Muratore, Gaia Capoferri, Serena Massa, Sofia Rahman, Susanna Esposito, Riccardo Masetti
Infections pose a significant threat to morbidity and mortality during treatments for pediatric cancer patients. Efforts to minimize the risk of infection necessitate preventive measures encompassing both environmental and host-focused strategies. While a substantial number of infections in oncologic patients originate from microorganisms within their native microbiological environment, such as the oral cavity, intestines, and skin, the concrete risk of bloodstream infections linked to the consumption of contaminated food and beverages in the community cannot be overlooked...
March 27, 2024: Nutrients
#2
JOURNAL ARTICLE
Francesco Venturelli, Davide Leardini, Francesco Baccelli, Francesca Gottardi, Veronica Barat, Francesca Vendemini, Veronica Maria Folsi, Cristina Meazza, Maddalena Marinoni, Maria Ester Bernardo, Manuela Tumino, Alessandra Brugiolo, Cristina Pizzato, Laura Battisti, Patrizia Bertolini, Alessia Pancaldi, Simona Rinieri, Roberta Pericoli, Paola Coccia, Daniela Onofrillo, Francesco Fabozzi, Simona Bianchi, Daniela Rizzo, Rosa Maria Daniele, Pio Stellato, Arcangelo Prete, Riccardo Masetti, Edoardo Muratore
UNLABELLED: Nutritional status plays a crucial role in the mortality rates of the pediatric oncology patients. However, there is a lack of systematic approaches for nutritional assessment in this population. This study aims to assess the current practice for nutritional assessment and care of pediatric cancer patients in Italy. A 25-items web-based, nation-wide questionnaire was circulated as of January 9, 2023 among physicians within the AIEOP network, composed of 49 national centers, out of which 21 routinely perform HCT...
December 14, 2023: European Journal of Pediatrics
#3
REVIEW
Burçin Karavelioglu, Taygun Dayi, Fatma Hacet
A low immune response is fatal for humans because increased infection risk is related to both morbidity and mortality. The neutropenic diet is applied if a person's neutrophil count is <2000 cells/μL. When compared with standard nutrition treatment, the neutropenic diet is found to be related to deficiencies in dietary fiber, vitamins C, A, and D, magnesium, and calcium. This is also related to malnutrition in patients diagnosed with cancer. Although raw vegetables are good sources of these nutrients, they can also be sources of pathogen microorganisms...
January 2024: Nutrition Research
#4
REVIEW
Ana Paula Carvalho Arnhold, Hana Gabriela Severino Araújo, Ana Facury Cruz, Mayla Cardoso Fernandes Toffolo, Silvia Fernandes Mauricio
OBJECTIVE: to carry out a scoping review with the purpose of mapping the scientific evidence on the use of the neutropenic diet in neutropenic pediatric cancer patients. SOURCE OF DATA: The scoping review protocol was prepared in accordance with the PRISMA-ScR and the checklist before the literature search was performed. Articles on nutritional management in adults or on the treatment of other diseases, and articles that were not in Portuguese or English and published before the year 2000, were excluded...
October 6, 2023: Jornal de Pediatria
#5
REVIEW
Sofia Matteucci, Giulia De Pasquale, Manuela Pastore, Emanuela Morenghi, Veronica Pipitone, Fanny Soekeland, Riccardo Caccialanza, Beatrice Mazzoleni, Stefano Mancin
The low-bacterial diet (LBD) is a widely used dietary regimen to reduce the risk of food-borne infections in patients with neutropenic cancer, but its role is controversial due to its unclear benefits. The purpose of this study was to provide an updated analysis of the available evidence on the efficacy of the LBD to reduce the risk of infections, mortality rates, and quality of life (QoL) in neutropenic patients with cancer. A systematic literature search was conducted in the biomedical databases Cochrane Library, PubMed, CINHAL, and EMBASE...
July 17, 2023: Nutrients
#6
REVIEW
Jannik Stemler, Sibylle C Mellinghoff, Yascha Khodamoradi, Rosanne Sprute, Annika Y Classen, Sonja E Zapke, Martin Hoenigl, Robert Krause, Martin Schmidt-Hieber, Werner J Heinz, Michael Klein, Philipp Koehler, Blasius Liss, Michael Koldehoff, Christoph Buhl, Olaf Penack, Georg Maschmeyer, Enrico Schalk, Cornelia Lass-Flörl, Meinolf Karthaus, Markus Ruhnke, Oliver A Cornely, Daniel Teschner
Patients with haematological malignancies (HM) are at high risk of developing invasive fungal disease (IFD) with high morbidity and attributable mortality. We reviewed data published until September 2021 to update the 2017 antifungal prophylaxis recommendations of the German Society of Haematology and Medical Oncology (DGHO). The strong recommendation to administer antifungal prophylaxis in patients with HM with long-lasting neutropenia, i.e. <500 cells/μL for >7 days remains unchanged. Posaconazole remains the drug of choice for mould-active prophylaxis in these patients...
August 2, 2023: Journal of Antimicrobial Chemotherapy
#7
JOURNAL ARTICLE
Thomas De Bock, Liesbeth Jacxsens, Femke Maes, Svenya Van Meerhaeghe, Marina Reygaerts, Mieke Uyttendaele
The current society consists of an increasing number of people vulnerable to infections. For certain people with severe immunodeficiency, a neutropenic or low-microbial diet is being prescribed, which substitutes high-risk foods that are more likely to contain human (opportunistic) pathogens with lower-risk alternatives. These neutropenic dietary guidelines are typically set up from a clinical and nutritional perspective, rather than from a food processing and food preservation perspective. In this study, the current guidelines in use by the Ghent University Hospital were evaluated based on the current knowledge of food processing and preservation technologies and the scientific evidence on microbiological quality, safety, and hygiene of processed foods...
2023: Frontiers in Microbiology
#8
JOURNAL ARTICLE
Carly B Gomez, Jade Mitchell, Elliot T Ryser, Bradley P Marks
The foodborne pathogen Listeria monocytogenes generally infects immunocompromised individuals, such as cancer patients, more frequently and with higher morbidity and mortality than the general population. Because of the anticipated risk associated with L. monocytogenes and other pathogens in produce, immunocompromised individuals are often placed on neutropenic diets that exclude fresh produce, though these risks have not been quantified. Therefore, this study developed a data-driven risk model for listeriosis in cancer patients who consume ready-to-eat (RTE) salads, consisting of leafy greens, cucumbers, and tomatoes, as influenced by kitchen-scale treatments and storage practices...
March 31, 2023: Journal of Food Protection
#9
JOURNAL ARTICLE
Alisa Morris, Graeme O' Connor, Gemma Renshaw
FOOD SAFETY AND PEDIATRIC CANCER: Neutropenia is a common complication of chemotherapy, which poses a high risk of infection and mortality. Neutropenic diet has historically been recommended for those undergoing chemotherapy. The rationale is to reduce the risk of foodborne infection by avoiding foods considered to be of high microbial risk. However, evidence for this diet is limited, and there is a lack of national consensus guidelines. AIM: Ascertain food safety advice across specialist centers providing high-dose chemotherapy for malignancy or stem cell transplants in the United Kingdom...
March 1, 2023: Journal of Pediatric Hematology/oncology
#10
JOURNAL ARTICLE
Gwendolyn N Y van Gorkom, Lara S Boerenkamp, Birgit L M G Gijsbers, Heidi H van Ojik, Will K W H Wodzig, Lotte Wieten, Catharina H M J Van Elssen, Gerard M J Bos
Vitamin C is an important micronutrient for various immune cells. It increases phagocytic cell function and is necessary for T and natural killer (NK) cell development. Patients in need of an autologous hematopoietic stem cell transplantation (HSCT) are often vitamin C-depleted. We therefore hypothesized that vitamin C supplementation could improve immune recovery in autologous HSCT patients. This blinded, placebo-controlled trial included 44 patients randomized to receive vitamin C or a placebo. The following outcome measures used were clinical and immunological parameters, among others: time to neutrophil recovery, serum, and intracellular vitamin C values...
November 11, 2022: Nutrients
#11
JOURNAL ARTICLE
Zaker I Schwabkey, Diana H Wiesnoski, Chia-Chi Chang, Wen-Bin Tsai, Dung Pham, Saira S Ahmed, Tomo Hayase, Miriam R Ortega Turrubiates, Rawan K El-Himri, Christopher A Sanchez, Eiko Hayase, Annette C Frenk Oquendo, Takahiko Miyama, Taylor M Halsey, Brooke E Heckel, Alexandria N Brown, Yimei Jin, Mathilde Raybaud, Rishika Prasad, Ivonne Flores, Lauren McDaniel, Valerie Chapa, Philip L Lorenzi, Marc O Warmoes, Lin Tan, Alton G Swennes, Stephanie Fowler, Margaret Conner, Kevin McHugh, Tyler Graf, Vanessa B Jensen, Christine B Peterson, Kim-Anh Do, Liangliang Zhang, Yushu Shi, Yinghong Wang, Jessica R Galloway-Pena, Pablo C Okhuysen, Carrie R Daniel-MacDougall, Yusuke Shono, Marina Burgos da Silva, Jonathan U Peled, Marcel R M van den Brink, Nadim Ajami, Jennifer A Wargo, Pavan Reddy, Raphael H Valdivia, Lauren Davey, Gabriela Rondon, Samer A Srour, Rohtesh S Mehta, Amin M Alousi, Elizabeth J Shpall, Richard E Champlin, Samuel A Shelburne, Jeffrey J Molldrem, Mohamed A Jamal, Jennifer L Karmouch, Robert R Jenq
Not all patients with cancer and severe neutropenia develop fever, and the fecal microbiome may play a role. In a single-center study of patients undergoing hematopoietic cell transplant ( n = 119), the fecal microbiome was characterized at onset of severe neutropenia. A total of 63 patients (53%) developed a subsequent fever, and their fecal microbiome displayed increased relative abundances of Akkermansia muciniphila , a species of mucin-degrading bacteria ( P = 0.006, corrected for multiple comparisons)...
November 16, 2022: Science Translational Medicine
#12
JOURNAL ARTICLE
Nitesh Dahiya, Ruchika Rani, Uttam K Nath
BACKGROUND: Patients diagnosed with cancer and who undergo cancer treatment are at potential risk of bone marrow suppression leading to prolonged hospitalization, delay in treatment, and chemotherapy dose reductions, which ultimately results in significant morbidity and mortality. This sequential exploratory study using a mixed-method approach was aimed to develop and validate a neutropenic nursing care (NNC) bundle for neutropenic patients admitted in a tertiary care hospital, Uttarakhand...
2022: Journal of Education and Health Promotion
#13
RANDOMIZED CONTROLLED TRIAL
Venkatraman Radhakrishnan, Perraju Bhaskar Bhuvan Lagudu, Devleena Gangopadhyay, Varalakshmi Vijaykumar, Swaminathan Rajaraman, Jayachandran Perumal Kalaiyarasi, Prasanth Ganesan, Trivadi S Ganesan
OBJECTIVES: Restriction of raw fruits and vegetables (neutropenic diet) is advised for patients receiving treatment for acute leukaemia in low-income and middle-income countries (LMICs) to reduce infections despite evidence to the contrary from high-income countries. We, therefore, conducted a randomised controlled trial to ascertain the efficacy of the neutropenic diet in an LMIC setting. METHODS: Patients aged 1-60 years receiving induction chemotherapy for acute leukaemia were randomised to a regular or neutropenic diet...
December 2022: BMJ Supportive & Palliative Care
#14
REVIEW
Jennifer A Ligibel, Kari Bohlke, Anne M May, Steven K Clinton, Wendy Demark-Wahnefried, Susan C Gilchrist, Melinda L Irwin, Michele Late, Sami Mansfield, Timothy F Marshall, Jeffrey A Meyerhardt, Cynthia A Thomson, William A Wood, Catherine M Alfano
PURPOSE: To provide guidance on exercise, diet, and weight management during active cancer treatment in adults. METHODS: A systematic review of the literature identified systematic reviews and randomized controlled trials evaluating the impact of aerobic and resistance exercise, specific diets and foods, and intentional weight loss and avoidance of weight gain in adults during cancer treatment, on quality of life, treatment toxicity, and cancer control. PubMed and the Cochrane Library were searched from January 2000 to May 2021...
August 1, 2022: Journal of Clinical Oncology
#15
Yimei Ma, Xiaoxi Lu, Hanmin Liu
Background: The purpose of this systematic review and meta-analysis was to evaluate the effect of a neutropenic diet and a control diet on infection and mortality rates in oncology patients with neutropenia. Methods: We searched the following English electronic databases: PubMed, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar Engine. Published studies involving neutropenic diets (study group) and control diets (control group) in oncology patients with neutropenia were searched...
2022: Frontiers in Oncology
#16
JOURNAL ARTICLE
Kathryn Fakier, Wenqing Xu
The neutropenic diet has long been a dietary prescription for immunocompromised patients. Its effectiveness and consistency, unfortunately, have been constantly challenged. Researchers and healthcare policymakers call for liberalization of neutropenic diet, which shifts risk management strategies from excluding claimed "high-risk" food items to focus on safe food handling. The responsibility of food safety falls on foodservice workers in a healthcare setting. The objective of this study was to develop and conduct psychometric testing to determine the validity and reliability of a self-assessment survey instrument tool targeting beliefs, attitudes, and behaviors of safe food handling practices for healthcare foodservice workers...
December 16, 2021: Journal of Food Protection
#17
LETTER
Pat Groff, Brittney Baer
I have found Clinical Journal of Oncology Nursing (CJON) articles to be enlightening and well written, and I look forward to reading CJON monthly to expand my general cancer care knowledge. I have been a blood and marrow transplantation (BMT) nurse since 1976; our BMT program birthed the chimeric antigen receptor (CAR) T-cell program. In October 2020, I retired as a BMT supervisor and policy keeper from the Seattle Cancer Care Alliance (SCCA), so I am very familiar with both specialties. I was lucky to spend my career at the Fred Hutchinson Cancer Research Center (FHCRC), which has emphasized research at its core...
October 1, 2021: Clinical Journal of Oncology Nursing
#18
JOURNAL ARTICLE
Carolin E M Jakob, Annika Y Classen, Melanie Stecher, Andreas Engert, Meike Freund, Axel Hamprecht, Nathalie Jazmati, Hilmar Wisplinghoff, Michael Hallek, Oliver A Cornely, Jörg J Vehreschild
BACKGROUND: Many haematology/oncology departments still provide a germ-free diet for neutropenic patients (neutropenic diet, ND) to minimise pathogen exposure, even though evidence on benefits is missing. We analysed the effects of a standard diet (SD) in neutropenic high-risk patients with cancer while focussing on infection-related outcomes. PATIENTS AND METHODS: Based on the Cologne Cohort of Neutropenic Patients, we conducted a propensity score-matched case-control study in haematological/oncological patients with a period of neutropenia longer than five days treated at our department between January 2004 and December 2012 (implementation of SD in January 2008)...
August 13, 2021: European Journal of Cancer
#19
JOURNAL ARTICLE
Ryo Nakatani, Koki Shimizu, Takahiro Matsuo, Ryosuke Koyamada, Nobuyoshi Mori, Takuya Yamashita, Shinichiro Mori
BACKGROUND: Campylobacter fetus is an uncommon Campylobacter species, and its infections mainly cause infective endocarditis, aortic aneurysm, and meningitis rather than enteritis. It is more likely to be detected in blood than Campylobacter jejuni or Campylobacter coli, specifically reported in 53% of patients. In our case, C. fetus was detected in both blood and cerebrospinal fluid (CSF) cultures. CASE PRESENTATION: A 33-year-old woman, who was on maintenance chemotherapy for acute lymphoblastic leukemia (ALL), presented to our clinic with chief complaints of severe headache and nausea...
July 13, 2021: BMC Infectious Diseases
#20
JOURNAL ARTICLE
Carly B Gomez, Elliot T Ryser, Bradley P Marks
Listeriosis, a foodborne illness caused by Listeria monocytogenes, has relatively low incidence, but a substantial mortality rate, particularly in immunocompromised populations. Because of the known risk of L. monocytogenes and other pathogens in produce, immunocompromised individuals are often placed on neutropenic diets that exclude fresh produce. Therefore, this study aimed to evaluate several kitchen-scale treatments as potential interventions to reduce L. monocytogenes in prepared produce. Cucumbers, apples, and celery were dip inoculated with a three-strain cocktail of L...
September 1, 2021: Journal of Food Protection
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