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Staphylococcal scalded skin syndrome

https://read.qxmd.com/read/38427766/staphylococcal-scalded-skin-syndrome-in-neonate-another-face-of-ca-mrsa
#1
JOURNAL ARTICLE
M Mohamadiya Rizwana, S Shanmugapriya, M Jaya Sudha, B Appalaraju, S Ramesh
Staphylococcal scalded skin syndrome (SSSS), also known as Ritter's disease, in its severe form occurs predominantly in infants and children. It is caused by infection with group II (often phage group 71) Staphylococcus aureus. The foci of infection include nasopharynx, less commonly umbilicus, urinary tract, superficial abrasion, conjunctivae, and blood. Staphylococci are non-motile, non-spore-forming, catalase-positive, gram-positive cocci that appear predominantly as grape-like clusters. Although this organism is frequently a part of normal human microbial flora, it can cause significant opportunistic infections under certain conditions such as when extremes of age groups are involved, the presence of indwelling medical devices, and intravenous (iv) drug abuse...
February 19, 2024: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38213362/acute-generalized-exanthematous-pustulosis-in-a-hemodialysis-patient
#2
J'Moi Saunders Corea, Kaley B Schwartz, Ilya Fonarov, Damian Casadesus
Acute generalized exanthematous pustulosis (AGEP) is an uncommon skin condition that should be considered when evaluating patients with severe skin eruptions accompanied by systemic symptoms. We present a woman in her 70s with end-stage renal disease on hemodialysis who developed a generalized pruritic rash seven days after the administration of pre-procedure vancomycin and acetaminophen. Our patient underwent a biopsy with findings consistent with AGEP. This report highlights the need to consider AGEP in patients with severe cutaneous eruptions and systemic involvement...
December 2023: Curēus
https://read.qxmd.com/read/38203566/molecular-characteristics-and-pathogenicity-of-staphylococcus-aureus-exotoxins
#3
REVIEW
Zhihao Zhu, Zuo Hu, Shaowen Li, Rendong Fang, Hisaya K Ono, Dong-Liang Hu
Staphylococcus aureus stands as one of the most pervasive pathogens given its morbidity and mortality worldwide due to its roles as an infectious agent that causes a wide variety of diseases ranging from moderately severe skin infections to fatal pneumonia and sepsis. S. aureus produces a variety of exotoxins that serve as important virulence factors in S. aureus -related infectious diseases and food poisoning in both humans and animals. For example, staphylococcal enterotoxins (SEs) produced by S. aureus induce staphylococcal foodborne poisoning; toxic shock syndrome toxin-1 (TSST-1), as a typical superantigen, induces toxic shock syndrome; hemolysins induce cell damage in erythrocytes and leukocytes; and exfoliative toxin induces staphylococcal skin scalded syndrome...
December 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38033678/congenital-staphylococcal-scalded-skin-syndrome-in-a-preterm-infant
#4
Ting-Yu Lee, Tzu-Yu Liu
Staphylococcal scalded skin syndrome (SSSS) is a rare condition in premature infants. We report a case of SSSS in a preterm neonate who displayed all clinical manifestations at birth, leading to a fatal outcome from Candida parapsilosis fungemia. The clinical presentation was challenging to differential diagnosis. SSSS diagnosis was confirmed by skin biopsy. This case emphasizes the significance of early recognition and diagnosis of SSSS promptly for clinicians. Congenital SSSS in premature infants can be fatal, but with early recognition and appropriate supportive and antimicrobial therapy, outcomes can be improved and lives can be saved...
December 2023: Clinical Case Reports
https://read.qxmd.com/read/38010554/-sad-man-facies-in-a-preterm-neonate-with-staphylococcal-scalded-skin-syndrome
#5
JOURNAL ARTICLE
Satya Prakash, Deepika Kainth
No abstract text is available yet for this article.
November 27, 2023: Indian Journal of Pediatrics
https://read.qxmd.com/read/37829935/bullous-pemphigoid-in-a-centenarian-male-simulating-toxic-epidermal-necrolysis
#6
Muna Shakhashiro, Taylor R Bradley, Stuart Tobin
Bullous pemphigoid (BP) is one of the most common autoimmune blistering diseases and classically presents as large, tense bullae. We report a case of BP with toxic epidermal necrolysis (TEN)-like manifestations in a 103-year-old male, the oldest known patient to present with an acute onset of BP. Our patient presented with extensive erosive lesions comprising 12% of the total body surface area, raising suspicion of TEN and Staphylococcal scalded skin syndrome. Detailed clinical, histological, and immunofluorescence analyses were performed, confirming a diagnosis of BP...
September 2023: Curēus
https://read.qxmd.com/read/37605396/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-an-overview-of-diagnosis-therapy-options-and-prognosis-of-patients
#7
JOURNAL ARTICLE
Vivek Kumar Garg, Harpal S Buttar, Sajad Ahmad Bhat, Nuftieva Ainur, Tannu Priya, Dharambir Kashyap, Hardeep Singh Tuli
Both Stevens-Johnson syndrome (SJS) and Toxic-epidermal necrolysis (TEN) are generally medication-induced pathological conditions that mostly affect the epidermis and mucus membranes. Nearly 1 to 2 patients per 1,000,000 population are affected annually with SJS and TEN, and sometimes these maladies can cause serious life-threatening events. The reported death rates for SJS range from 1 to 5%, and 25 to 35% for TEN. The mortality risk may even be higher among elderly patients, especially in those who are affected by a significant amount of epidermal detachment...
August 21, 2023: Recent advances in inflammation & allergy drug discovery
https://read.qxmd.com/read/37601422/recurrent-staphylococcal-scalded-skin-syndrome-in-a-20-month-old-a-case-report
#8
Camille Basurto, Nada Baah-Owusu, Kyla Berreth
We present a case of a 20-month-old child with a history of atopic dermatitis that exhibited recurrent erythematous-bullous lesions consistent with Staphylococcal Scalded Skin syndrome (SSSS). SSSS is an exfoliative toxin-mediated skin disorder most commonly found in children. In this paper, we discuss the importance of recognizing the clinical symptomatology and progressive nature of SSSS, particularly in patients with a history of atopic dermatitis, to ensure prompt treatment and resolution of the syndrome...
August 2023: Clinical Case Reports
https://read.qxmd.com/read/37593888/fast-bedside-diagnosis-of-toxic-epidermal-necrolysis-using-ex-vivo-confocal-laser-scanning-microscopy-a-retrospective-study
#9
JOURNAL ARTICLE
L Tonellotto, T Seremet, M Vernez, E Guenova, F Kuonen
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe life-threatening drug eruption with rapid evolution. A fast histologic differentiation between TEN and clinically similarly looking staphylococcal scalded skin syndrome is of vital importance for relevant treatment decision. The recently developed ex vivo confocal laser scanning microscopy (CLSM) offers innovative and extremely fast histological visualization of fresh tissue specimens. OBJECTIVE: To assess the diagnostic efficacy of ex vivo CLSM in comparison with standard histopathology for TEN...
August 18, 2023: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/37404367/associated-outcomes-of-different-intravenous-antibiotics-combined-with-2-mupirocin-ointment-in-the-treatment-of-pediatric-patients-with-staphylococcal-scalded-skin-syndrome
#10
JOURNAL ARTICLE
Cong You, Zhiwei Wu, Mingyi Liao, Xiaoying Ye, Longnian Li, Tao Yang
PURPOSE: To compare treatment duration, influencing factors, and costs among intravenous antibiotic groups combined with 2% mupirocin ointment for treating staphylococcal scalded skin syndrome (SSSS). PATIENTS AND METHODS: Sex, age, onset days before admission, febrile status, white blood cell (WBC) count, and C-reactive protein (CRP) level were recorded as baseline characteristics for 253 included patients. The antibiotic sensitivity results were statistically compared by Cochran's Q test...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/37106994/staphylococcal-infections-and-neonatal-skin-data-from-literature-and-suggestions-for-the-clinical-management-from-four-challenging-patients
#11
REVIEW
Domenico Umberto De Rose, Flaminia Pugnaloni, Ludovica Martini, Iliana Bersani, Maria Paola Ronchetti, Andrea Diociaiuti, May El Hachem, Andrea Dotta, Cinzia Auriti
Staphylococcal infections in neonates might be associated with skin blistering since early antibiotic therapy has been shown to limit infection spread and positively influence outcomes; therefore, neonatologists should be aware of these conditions. This review examines the recent literature on the management of Staphylococcal infections that involve neonatal skin, discussing the most appropriate clinical approach to four cases of neonatal blistering diseases with Staphylococcal infections: a case of Staphylococcal bullous impetigo, a case of Staphylococcal scalded skin syndrome (SSSS), a case of epidermolysis bullosa with overlapping Staphylococcal infection, and a case of burns with overlapping Staphylococcal infection...
March 23, 2023: Antibiotics
https://read.qxmd.com/read/37097288/evolving-trends-in-inpatient-paediatric-dermatology
#12
REVIEW
Juliana Pineider, Vikash S Oza, Sarah D Cipriano
PURPOSE OF REVIEW: This review provides updates in the evaluation and management of key dermatologic diseases encountered in the hospitalized child. RECENT FINDINGS: Our understanding of dermatologic disorders in children continues to evolve. Staphylococcal scalded skin syndrome (SSSS) is a potentially severe blistering disorder typically seen in children under the age of 4 with an incidence that is increasing in the United States. Recent research has highlighted that the majority of cases are due to methicillin-sensitive Staphylococcus aureus (MSSA) and most patients can be adequately managed with beta-lactams...
August 1, 2023: Current Opinion in Pediatrics
https://read.qxmd.com/read/37085240/staphylococcal-scalded-skin-syndrome-in-a-child
#13
JOURNAL ARTICLE
Qinwei Qian, Jinyue Shen, Angela Vinturache, Guodong Ding
No abstract text is available yet for this article.
May 2023: Lancet Infectious Diseases
https://read.qxmd.com/read/36998271/prevalence-and-clinical-characteristics-of-methicillin-resistant-staphylococcus-aureus-infections-among-dermatology-inpatients-a-7-year-retrospective-study-at-a-tertiary-care-center-in-southwest-china
#14
JOURNAL ARTICLE
Zhijian Yao, Yidan Wu, Hongming Xu, Ying Lei, Wanyu Long, Meixian Li, Yue Gu, Zhiwen Jiang, Cunwei Cao
BACKGROUND: Increased rates of methicillin-resistant Staphylococcus aureus (MRSA) antibiotic resistance and the associated morbidity have increased dermatologists' attention to skin and soft tissue MRSA infections. However, the clinical characterization of MRSA skin and soft tissue infections (SSTIs) in Southwest China is lacking, which precludes optimal prevention and treatment of these infections. OBJECTIVES: This study was conducted to characterize the prevalence, clinical comorbidities and antibiotic susceptibility of MRSA isolates from SSTIs, including community-associated (CA) and healthcare-associated (HA) isolates...
2023: Frontiers in Public Health
https://read.qxmd.com/read/36858968/epidermolysis-in-a-newborn-of-a-mother-affected-by-covid-19-in-the-3rd-trimester-of-pregnancy
#15
JOURNAL ARTICLE
Erik Dosedla, Petra Gašparová, Zuzana Ballová, Kamila Radaljová, Pavel Calda
Covid-19, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently a pandemic. Although this infection primarily presents with respiratory symptoms, the number of reported extrapulmonary manifestations, including dermatological, is also increasing. A group of pregnant women is particularly susceptible to respiratory diseases, but with regard to covid-19, there is still limited data on the course of infection in pregnancy in relation to the possibility of vertical transmission. We present the case of a 30-year-old unvaccinated patient with a history of overcoming covid-19 infections in the 7th month of pregnancy, and with persistent skin lesions...
2023: Ceská Gynekologie
https://read.qxmd.com/read/36809131/epidermolytic-ichthyosis-complicated-by-staphylococcal-scalded-skin-syndrome-in-the-newborn
#16
JOURNAL ARTICLE
Gabrielle M Peck, Kelsey Flood, Kalyani Marathe
Epidermolytic ichthyosis is characterized by erythema and blistering at birth. We present a neonate with epidermolytic ichthyosis who had a subtle change in clinical findings while hospitalized, including increased fussiness, erythema, and a change in her skin odor, which represented superimposed staphylococcal scalded skin syndrome. This case highlights the unique challenge of recognizing cutaneous infections in neonates with blistering skin disorders and emphasizes the importance of having a high suspicion for superinfection in this population...
October 15, 2022: Dermatology Online Journal
https://read.qxmd.com/read/36671239/staphylococcal-scalded-skin-syndrome-in-neonates-case-series-and-overview-of-outbreaks
#17
REVIEW
Charlotte M Nusman, Charlotte Blokhuis, Dasja Pajkrt, Douwe H Visser
Skin and soft tissue infections caused by Staphylococcus aureus ( S. aureus ) cover a wide spectrum of diseases in neonates, including staphylococcal scalded skin syndrome (SSSS). We describe a representative case of SSSS in neonatal twins, which despite recurrence showed a mild clinical disease course. This case was part of a small outbreak on a neonatal intensive care unit and therefore exemplifies the existence of neonatal outbreaks with skin and soft tissue infections by S. aureus. Diagnosis is generally based on the clinical picture and response to antibiotics, but can be aided by histology and cultures...
December 26, 2022: Antibiotics
https://read.qxmd.com/read/36440996/staphylococcal-scalded-skin-syndrome-clinical-features-ancillary-testing-and-patient-management
#18
JOURNAL ARTICLE
Laurel Gray, Jared Olson, Ben J Brintz, Sarah D Cipriano
BACKGROUND/OBJECTIVES: The utility of ancillary testing in improving diagnostic precision or improving patient outcomes in staphylococcal scalded skin syndrome (SSSS) is unclear. Similarly, an optimal antibiotic regimen has yet to be established. Our goal was to describe clinical characteristics and ancillary work-up of SSSS, report bacterial resistance patterns, and examine patient outcomes under varying therapeutic strategies with the aim of developing an evidence-based management algorithm...
November 2022: Pediatric Dermatology
https://read.qxmd.com/read/36408080/staphylococcal-scalded-skin-syndrome-in-adults-with-obesity-and-type-2-diabetes-a-case-series
#19
Carolina Vitale, Valentina Spinozzi, Luca Colangeli, Paolo Sbraccia, Valeria Guglielmi
Staphylococcal scalded skin syndrome (SSSS) primarily affects children and rarely adults with immunodepression. We describe two cases of adults diagnosed with SSSS with no additional cause of immunological compromise other than obesity and uncontrolled diabetes. An increased risk of infection should be considered in cases of obesity and diabetes.
November 2022: Clinical Case Reports
https://read.qxmd.com/read/35989790/staphylococcal-scalded-skin-syndrome-in-a-ten-month-old-male
#20
Margaux Baatz, Heather L Holley, John Ahlert, Maxwell J Rubin
A 10-month-old male presented with rhinorrhea and decreased oral intake and was diagnosed with an upper respiratory infection. Two days later, he returned to the clinic due to a lack of improvement and the onset of new symptoms, including facial edema and perioral skin irritation. That evening, he became febrile at 100.4 °F and went to the emergency department at the local children's hospital. No further workup was done and the parents were instructed to continue with the current treatment regimen. Over the next 48 hours, the patient's symptoms worsened with the new onset of bilateral extremity edema and desquamation...
July 2022: Curēus
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