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Staphylococcal scalded skin syndrome

Anastassios Doudoulakakis, Iris Spiliopoulou, Nikolaos Spyridis, Nikolaos Giormezis, John Kopsidas, Maria Militsopoulou, Evangelia Lebessi, Maria Tsolia
Objectives: Skin and soft tissue infections (SSTIs) caused by mupirocin-resistant Staphylococcus aureus strains have recently increased in our settings. We sought to evaluate the characteristics of these cases over a 43-month period.Methods: All community-acquired staphylococcal infections caused by mupirocin-resistant strains were retrospectively reviewed. Genes encoding high level (HLR) mupirocin resistance (mupA), fusidic acid resistance (fusB), ermA, ermC, PVL (lukS/lukF-PV), exfoliative toxins (eta, etb), fibronectin binding protein A (fnbA) were investigated in 102 preserved selected strains by PCRs...
June 7, 2017: Journal of Clinical Microbiology
Sonia Valero-Portero, Lorenzo Quesada-Dorigne, Juan José Quesada López, Ángel Bernardo Brea-Lamas, Manuel Cidrás-Pidré
No abstract text is available yet for this article.
May 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
Onofrio Lamanna, Dafne Bongiorno, Lisa Bertoncello, Stefano Grandesso, Sandra Mazzucato, Giovanni Battista Pozzan, Mario Cutrone, Michela Chirico, Flavia Baesso, Pierluigi Brugnaro, Viviana Cafiso, Stefania Stefani, Floriana Campanile
BACKGROUND: The aims of this study were to identify the source and the transmission pathway for a Staphylococcal Scalded Skin Syndrome (SSSS) outbreak in a maternity setting in Italy over 2 months, during 2014; to implement appropriate control measures in order to prevent the epidemic spread within the maternity ward; and to identify the Methicillin-Resistant Staphylococcus aureus (MRSA) epidemic clone. METHODS: Epidemiological and microbiological investigations, based on phenotyping and genotyping methods, were performed...
January 6, 2017: Italian Journal of Pediatrics
Hyejin Jeon, Sang Hyuk Ma, Hyun Jin Jo, Min-Seok Woo, Hyeonjun An, Hyungsik Park, Choongeun Kwon, Youjeong Kim, Je Chul Lee
No abstract text is available yet for this article.
December 2016: Journal of Medical Microbiology
Montina Dudley, Bridget Parsh
No abstract text is available yet for this article.
December 2016: Nursing
L Franco, P Pereira
No abstract text is available yet for this article.
October 8, 2016: Indian Pediatrics
Arun K Mishra, Pragya Yadav, Amrita Mishra
The symptoms of Staphylococcal scalded skin syndrome (SSSS) include blistering of skin on superficial layers due to the exfoliative toxins released from Staphylococcus aureus. After the acute exfoliation of skin surface, erythematous cellulitis occurs. The SSSS may be confined to few blisters localized to the infection site and spread to severe exfoliation affecting complete body. The specific antibodies to exotoxins and increased clearence of exotoxins decrease the frequency of SSSS in adults. Immediate medication with parenteral anti-staphylococcal antibiotics is mandatory...
2016: Open Microbiology Journal
Y S Sarma, Manas Chatterjee, G L Tiwari, S K Kathuria, Atul Gupta
No abstract text is available yet for this article.
July 2004: Medical Journal, Armed Forces India
Juan Su, Ji Li, Haiyan Luo, Zhenghui Xiao, Binping Luo, Xiang Chen, Jie Li, Panpan Liu, Wu Zhu
OBJECTIVE: To realize the risk factors, clinical features, and treatments of Staphylococcal scalded skin syndrome (SSSS).
 METHODS: The clinical features, laboratory findings, and treatment were retrospectively analyzed in 290 patients from Hunan Children's Hospital.
 RESULTS: Of the 290 patients, less than 3 years old children were 76.6%. One hundred and nine patients had induced factors, and 177 patients had elevated white blood cell count...
April 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Dogu Aydin, Bjarne Alsbjørn
Benign impetigo can progress into a potential fatal staphylococcal scalded skin syndrome (SSSS) if prompt diagnosis and correct therapy is not established rapidly. Local and systematic antibiotics as well as Lactulose are crucial in order to stop SSSS from progressing. Burns units should be involved when skin lesions are extensive.
April 2016: Clinical Case Reports
Jonathan J Lee, Hillary C Tsibris, Arash Mostaghimi, Christine G Lian
Staphylococcal scalded skin syndrome is a toxin-mediated, epidermolytic condition that uncommonly affects adults. A 51-year-old man receiving chemotherapy for leukemia presented with a large geographic erosion with superficial sloughing and multiple smaller lesions elsewhere. Biopsy revealed complete subcorneal splitting with multiple detached fragments of normal-appearing stratum corneum with fragments of attached acantholytic granular keratinocytes. Mild epidermal dysmaturation was also noted. Based on these findings, the patient was started on oral cephalexin, topical mupirocin, and topical clobetasol...
August 2014: Dermatopathology (Basel, Switzerland)
Blake Galler, Casey Bowen, Jason Arnold, Todd Kobayashi, Scott R Dalton
Frozen section is a valuable tool that is often underutilized in the setting of in-patient dermatology. Traditionally, frozen section has been used in dermatology to diagnose toxic epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period. We report a newborn female with ruptured bullae on the face, chest, back and extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma/epidermolytic hyperkeratosis and epidermolysis bullosa...
May 2016: Journal of Cutaneous Pathology
Igor Abaev, Yury Skryabin, Angelina Kislichkina, Alexandr Bogun, Olga Korobova, Nadezhda Mayskaya, Igor Shemyakin, Ivan Dyatlov
Staphylococcus aureus clonal complex 8 (CC8) has not been associated with staphylococcal scalded-skin syndrome (SSSS) in newborns and exfoliative toxin genes. Here, we report the draft genome sequences of exfoliative toxin A-producing B-7772, B-7777 (both CC8), and B-7774 (CC15) strains associated with SSSS in newborns.
2016: Genome Announcements
Hyejin Jeon, Man Hwan Oh, So Hyun Jun, Seung Il Kim, Chi Won Choi, Hyo Il Kwon, Seok Hyeon Na, Yoo Jeong Kim, Asiimwe Nicholas, Gati Noble Selasi, Je Chul Lee
Staphylococcus aureus secretes membrane-derived vesicles (MVs), which can deliver virulence factors to host cells and induce cytopathology. However, the cytopathology of host cells induced by MVs derived from different S. aureus strains has not yet been characterized. In the present study, the cytotoxic activity of MVs from different S. aureus isolates on host cells was compared and the proteomes of S. aureus MVs were analyzed. The MVs purified from S. aureus M060 isolated from a patient with staphylococcal scalded skin syndrome showed higher cytotoxic activity toward host cells than that shown by MVs from three other clinical S...
April 2016: Microbial Pathogenesis
K Wiedemann, C Schmid, H Hamm, J Wirbelauer
INTRODUCTION: Staphylococcal scalded skin syndrome (SSSS) was often endemic in the past but is nowadays rare. The hematogeneous spread of exfoliative toxins A (ETA) or B (ETB) produced by specific Staphylococcus aureus strains causes a scald-like eruption with disseminated bullous lesions. CASE REPORT: A perioral impetigo lesion occurred on day 14 of life in a preterm male infant (1,065 g, 30 weeks of gestational age). Empiric antibiotic therapy with cefotaxime and vancomycin was given for 6 days and led to complete resolution...
February 2016: Zeitschrift Für Geburtshilfe und Neonatologie
Kourtney Hennigan, Cheryl Riley
Staphylococcal scalded skin syndrome (SSSS) is a rare yet well-known exfoliative skin syndrome. It involves extensive desquamated areas caused by an exfoliative toxin from Staphylococcus aureus. The typical presentation of SSSS allows for early diagnosis and treatment of the disease. Knowing and understanding the prevalence, pathophysiology, risk factors, and diagnosis of SSSS will ensure that infants being treated and cared for by neonatal nurses and neonatal nurse practitioners will receive appropriate, comprehensive, and multidisciplinary care while in the NICU...
2016: Neonatal Network: NN
A Horna Strand, S Rubertsson, F Huss, M Mani
This report concerns an 18-month-old boy who presented with a 6% total body surface area scald. The subject of this report is unique in that he developed the largest exfoliation described in literature. After 3 days an epidermal exfoliation with the appearance of a deliberately inflicted scald developed. As the exfoliation progressed to over 95% total body surface area the suspicion of child abuse or neglect could be abandoned. The diagnosis Staphylococcal scalded skin syndrome was set, due to the finding of Staphylococcus aureus on swabs, the lack of mucosal engagement, and the patient's age...
March 2016: Burns: Journal of the International Society for Burn Injuries
Dirk M Elston, Erik J Stratman, Stanley J Miller
Misdiagnosis may result from biopsy site selection, technique, or choice of transport media. Important potential sources of error include false-negative direct immunofluorescence results based on poor site selection, uninformative biopsy specimens based on both site selection and technique, and spurious interpretations of pigmented lesions and nonmelanoma skin cancer based on biopsy technique. Part I of this 2-part continuing medical education article addresses common pitfalls involving site selection and biopsy technique in the diagnosis of bullous diseases, vasculitis, panniculitis, connective tissue diseases, drug eruptions, graft-versus-host disease, staphylococcal scalded skin syndrome, hair disorders, and neoplastic disorders...
January 2016: Journal of the American Academy of Dermatology
Andreas Hörner, Rosmari Hörner, Adenilde Salla, Melise Silveira Nunes, Litiérri Razia Garzon, Roberta Filipini Rampelotto, Rosiéli Martini, Silvana Oliveira dos Santos, Lívia Gindri, Mônica de Abreu Rodrigues, Cláudia Giacomolli
CONTEXT: Staphylococcal scalded skin syndrome is an exfoliative skin disease. Reports of this syndrome in newborns caused by methicillin-resistant Staphylococcus aureus are rare but, when present, rapid diagnosis and treatment is required in order to decrease morbidity and mortality. CASE REPORT: A premature newly born girl weighing 1,520 g, born with a gestational age of 29 weeks and 4 days, developed staphylococcal scalded skin syndrome on the fifth day of life...
September 2015: São Paulo Medical Journal, Revista Paulista de Medicina
K Kouakou, M E Dainguy, K Kassi
We described a case of Staphylococcal Scalded Skin Syndrome in infant age of 21 days by discussing clinical and management issues. This newborn presented large erythematous, eroded, and oozing areas covered by epidermal skin flap. The average surface of cutaneous unsticking on admission was 31.35% of body surface area corresponding to lesions of superficial second-degree burns. An important biological inflammatory syndrome including positive C-reactive protein was found. Under treatment, erythroderma decreased within 7 to 10 days and the newborn was completely healed after 3 weeks of followup, with the disappearance of the inflammatory syndrome and total body surface restored...
2015: Case Reports in Dermatological Medicine
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