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methylene blue analgesic

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https://www.readbyqxmd.com/read/29883785/indole-alkaloids-and-anti-nociceptive-mechanisms-of-tabernaemontana-divaricata-l-r-br-flower-methanolic-extract
#1
Mohammed Safwan Ali Khan, Misbah, Nishat Ahmed, Mohammed Arifuddin, Abdullah Rehman, Mok Pooi Ling
Flowers of Tabernaemontana divaricata (L.) R. Br., (Apocynaceae) are used in traditional medicine for analgesic property. The present study was performed to isolate the active principles and investigate the mechanisms involved in the anti-nociception caused by T. divaricata flower methanolic extract (TDFME). The extract in the doses of 125, 250 and 500 mg/kg, p.o was subjected to various assays in acetic acid induced abdominal writhing and formalin induced paw licking test models. Naloxone, L-Arginine, Glibenclamide and Glutamate were used as inducers while Morphine, L-NAME, Methylene blue and Aspirin served as standard drugs...
June 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29851309/description-of-a-new-approach-for-great-auricular-and-auriculotemporal-nerve-blocks-a-cadaveric-study-in-foxes-and-dogs
#2
Thaleia-Rengina Stathopoulou, Rui Pinelas, Gert Ter Haar, Ine Cornelis, Jaime Viscasillas
Otitis externa is a painful condition that may require surgical intervention in dogs. A balanced analgesia protocol should combine systemic analgesic agents and local anaesthesia techniques. The aim of the study was to find anatomical landmarks for the great auricular and the auriculotemporal nerves that transmit nociceptive information from the ear pinna and to develop the optimal technique for a nerve block. The study consisted of two phases. In phase I, one fox cadaver was used for dissection and anatomical localization of the auricular nerves to derive landmarks for needle insertion...
May 2018: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29777732/antinociceptive-effect-of-tadalafil-in-various-pain-models-involvement-of-opioid-receptors-and-nitric-oxide-cyclic-gmp-pathways
#3
Mohammad M Mehanna, Souraya Domiati, Hania Nakkash Chmaisse, Ahmed El Mallah
Nitric oxide has been proven to play an important role in nociception, accordingly, its promoters, phosphodiesterase inhibitors have been investigated as pain response modulators. Aiming to evaluate the central effect of tadalafil, a phosphodiesterase 5 inhibitor, and to determine its EC50, tail flick and hot plate tests were utilized. On the other hand, its nociceptive peripheral analgesic effect was assessed through acetic-acid induced writhing model. Formalin test was used to appraise both non-inflammatory and inflammatory pain responses...
May 16, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29567278/antinociceptive-activity-of-inula-britannica-l-and-patuletin-in-vivo-and-possible-mechanisms-studies
#4
Mohammad Zarei, Saeed Mohammadi, Alireza Komaki
ETHNOPHARMACOLOGICAL RELEVANCE: Inula britannica L. is a predominant medicinal plant traditionally utilized in the treatments of arthritis and back pain in Iranian folk medicine. AIM OF THE STUDY: The purpose of this research was to evaluate the antinociceptive effects of Inula britannica L. flower essential oil (IBLEO) and one of its major constituents, Patuletin (Pn), in male mice. MATERIALS AND METHODS: In this study, we used pain assessment tests including acetic acid-induced writhing, tail-flick (TF), formalin induced paw licking (FIPL) model, and glutamate-induced paw licking (GPL)...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29380385/role-of-l-arginine-snap-no-cgmp-k-atp-channel-signalling-pathway-in-antinociceptive-effect-of-%C3%AE-terpineol-in-mice
#5
Sara Safaripour, Yasaman Nemati, Siavash Parvardeh, Shiva Ghafghazi, Anahita Fouladzadeh, Mahsa Moghimi
OBJECTIVES: The main purpose of this study was to assess the role of l-arginine/SNAP/NO/cGMP/KATP channel pathway in analgesic effects of α-terpineol in mice. METHODS: Male NMRI mice were pretreated intraperitoneally with NO precursor (l-arginine, 100 mg/kg), NO synthase inhibitor (l-NAME, 30 mg/kg), NO donor (SNAP, 1 mg/kg), guanylyl cyclase inhibitor (methylene blue, 20 mg/kg), PDE inhibitor (sildenafil, 0.5 mg/kg), KATP channel blocker (glibenclamide, 10 mg/kg) and naloxone (2 mg/kg) 20 min before the administration of α-terpineol...
April 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29174959/blind-versus-ultrasound-guided-maxillary-nerve-block-in-donkeys
#6
Usama Hagag, Mohamed G Tawfiek
OBJECTIVES: To describe the 'blind' and ultrasound-guided approaches to block the maxillary nerve in donkeys. To compare the success and complication rates between the 'blind' and ultrasound-guided techniques based on staining of nerves and other structures in cadavers and assessing level of analgesia in live animals. STUDY DESIGN: Prospective anatomical and experimental study. ANIMALS: Eighteen cadaver heads and nine adult live donkeys. METHODS: Phase 1: the anatomical characteristics of the maxillary nerve and its related structures were investigated within the pterygopalatine fossa in five cadavers...
January 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28894786/methylene-blue-effectiveness-as-local-analgesic-after-anorectal-surgery-a-literature-review
#7
REVIEW
Dewi Fransiska, Wifanto Saditya Jeo, Yefta Moenadjat, Dewi Friska
BACKGROUND: Methylene blue (MB) has been found to have unique analgesic property through temporary disruption of sensory nerve conduction. In anorectal surgery, MB is widely used as a biologic stain but the analgesic effect has never been studied. Thus, a literature review completed with critical appraisal is required to find out its efficacy. METHODS: A review has been run to find out its efficacy. Literature search proceeded in database sites, namely, PubMed, EBSCO, Cochrane, Wiley, and ProQuest using the following keywords: "anorectal" OR "hemorrhoid" OR "anal fistula" OR "anal fissure" OR "anal abscess" OR "anal pruritus" AND "methylene blue" AND "analgesic"; then the critical appraisal and its implication were discussed...
2017: Advances in Medicine
https://www.readbyqxmd.com/read/28875384/rare-cause-of-delirium-and-hypoxemia-after-coronary-bypass-surgery-transdermal-lidocaine-patch-associated-methemoglobinemia
#8
Fidel A Acevedo, Esther J Kim, David A Chyatte, Vance G Nielsen
We present a case of a patient administered parasternal transdermal lidocaine patch therapy as part of a multimodal analgesic regime designed to diminish opioid-associated delirium after coronary bypass surgery. The patient presented with delirium and severe methemoglobinemia (41%) that responded to discontinuation of lidocaine therapy, oxygen administration, and methylene blue administration. The clinical contributors and medicolegal implications of this degree of lidocaine-associated methemoglobin-mediated delirium are presented in the hope of avoiding similar complications in the postoperative setting after coronary bypass surgery...
May 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28867151/-axillary-local-anesthetic-spread-after-the-thoracic-interfacial-ultrasound-block-a-cadaveric-and-radiological-evaluation
#9
Patricia Alfaro de la Torre, Jerry Wayne Jones, Servando López Álvarez, Paula Diéguez Garcia, Francisco Javier Garcia de Miguel, Eva Maria Monzon Rubio, Federico Carol Boeris, Monir Kabiri Sacramento, Osmany Duany, Mario Fajardo Pérez, Borja de la Quintana Gordon
BACKGROUND: Oral opioid analgesics have been used for management of peri- and postoperative analgesia in patients undergoing axillary dissection. The axillary region is a difficult zone to block and does not have a specific regional anesthesia technique published that offers its adequate blockade. METHODS: After institutional review board approval, anatomic and radiological studies were conducted to determine the deposition and spread of methylene blue and local anesthetic injected respectively into the axilla via the thoracic inter-fascial plane...
September 1, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28444555/evaluating-the-effectiveness-of-a-novel-atomized-liquid-needle-free-transdermal-delivery-system
#10
Yi-Huei Huang, Chieh-Shen Hu, Yi-Jhen Ke, Chiao-Hsi Chiang, Po-Da Hong, Ming-Kung Yeh
Needle-free jet injections constitute a crucial method for drug delivery. A novel liquid drug delivery system has been proposed recently, in which pressure atomizes liquid before delivering that atomized liquid to the patient's body; however, the mechanism and efficiency of the system are unclear. This study explored the shot delivery pressure, penetration depth, and cumulative amount of permeation of this system. This system was used to deliver 0.5% (w/v) methylene blue to agarose phantoms at various shot delivery pressures...
October 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28263244/a-cadaveric-study-of-ultrasound-guided-subpectineal-injectate-spread-around-the-obturator-nerve-and-its-hip-articular-branches
#11
Thomas D Nielsen, Bernhard Moriggl, Kjeld Søballe, Jens A Kolsen-Petersen, Jens Børglum, Thomas Fichtner Bendtsen
BACKGROUND AND OBJECTIVES: The femoral and obturator nerves are assumed to account for the primary nociceptive innervation of the hip joint capsule. The fascia iliaca compartment block and the so-called 3-in-1-block have been used in patients with hip fracture based on a presumption that local anesthetic spreads to anesthetize both the femoral and the obturator nerves. Evidence demonstrates that this presumption is unfounded, and knowledge about the analgesic effect of obturator nerve blockade in hip fracture patients presurgically is thus nonexistent...
May 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28226414/methylene-blue-for-the-treatment-of-intractable-pain-associated-with-oral-mucositis
#12
Carlos J Roldan, Kent Nouri, Thomas Chai, Billy Huh
Oral mucositis is a common and often debilitating complication among cancer patients receiving radiation therapy to the head and neck or chemotherapy agents, or undergoing hematopoietic stem cell transplantation. Pain and decreased oral function associated with oral mucositis may persist long after the conclusion of therapy. Although most patients respond to conservative management, a subset of patients develops intractable pain with severe consequences. For some, the use of total parenteral nutrition with insertion of percutaneous endoscopic gastrostomy feeding tubes is the only alternative...
February 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27687351/new-technique-targeting-the-c5-nerve-root-proximal-to-the-traditional-interscalene-sonoanatomical-approach-is-analgesic-for-outpatient-arthroscopic-shoulder-surgery
#13
Katherine H Dobie, Yaping Shi, Matthew S Shotwell, Warren S Sandberg
STUDY OBJECTIVE: Regional anesthesia and analgesia for shoulder surgery is most commonly performed via interscalene nerve block. We developed an ultrasound-guided technique that specifically targets the C5 nerve root proximal to the traditional interscalene block and assessed its efficacy for shoulder analgesia. DESIGN: Prospective case series. SETTING: Vanderbilt Bone and Joint Surgery Center. PATIENTS: Patients undergoing shoulder arthroscopy at an ambulatory surgery center...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27651809/effects-of-topical-and-systemic-administration-of-eugenia-caryophyllata-buds-essential-oil-on-corneal-anesthesia-and-analgesia
#14
Emad Khalilzadeh, Reza Hazrati, Gholamreza Vafaei Saiah
Clinical studies suggest that essential oil of Eugenia caryophyllata (Clove) buds (EOEC) is efficacious in the treatment of dental pain. In the present study, we investigated the analgesic and local anesthetic effects of EOEC and its possible mechanisms of action in acute corneal pain in rats. EOEC was extracted by hydro-distillation in a Clevenger type apparatus from clove buds. The acute corneal pain was induced by applying a drop (40 µl) of 5 M NaCl solution on the corneal surface, and the numbers of eye wipes were counted during the first 30 s...
July 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26590962/efficacy-and-cost-effectiveness-of-intradiscal-methylene-blue-injection-for-chronic-discogenic-low-back-pain-study-protocol-for-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
José W Geurts, Jan-Willem Kallewaard, Alfons Kessels, Paul C Willems, Henk van Santbrink, Carmen Dirksen, Maarten van Kleef
BACKGROUND: Low back pain (LBP) is a common health problem and a substantial part of LBP is presumed to be attributable to degeneration of the intervertebral disc. For patients suffering from intractable discogenic LBP, there are few evidence-based effective interventional treatment options available. In 2010, the results of a randomized controlled trial (RCT) were published concerning "intradiscal methylene blue injection" (IMBI), in which this intervention appeared to be very successful in relieving discogenic pain...
November 21, 2015: Trials
https://www.readbyqxmd.com/read/26213475/evaluation-of-the-protein-biomarkers-and-the-analgesic-response-to-systemic-methylene-blue-in-patients-with-refractory-neuropathic-pain-a-double-blind-controlled-study
#16
Adriana A Miclescu, Martin Svahn, Torsten E Gordh
AIM: This study was carried out in patients with neuropathic pain in order to assess the analgesic effects and changes in protein biomarkers after the administration of methylene blue (MB), a diaminophenothiazine with antioxidant and anti-inflammatory properties, and with inhibitory effects on nitric oxide. MATERIALS AND METHODS: Ten patients with chronic refractory neuropathic pain were randomized to receive either MB (10 mg/mL Methylthioninium chloride) 2 mg/kg (MB group) or MB 0...
2015: Journal of Pain Research
https://www.readbyqxmd.com/read/26204654/the-effects-of-riboflavin-and-methylene-blue-on-nociception-and-visceral-pain
#17
A Luca, Teodora Alexa, A Dondaş, Irina-Mihaela Crăcană, Magda Bădescu, Cătălina Bohotin
BACKGROUND: Methylene Blue (MB) can prevent electron leaking, increase mitochondrial oxidative phosphorylation, and reduce ROS overproduction under pathological conditions, currently being trace evidence that it can alter pain perception in humans by local administration during certain surgical procedures. Riboflavin or vitamin B2 (B2) constitutes a part of the vitamin B group, which in recent studies shows a growing implication in the treatment of some pathology that imply pain management...
April 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/26072010/-a-pleural-transudate-with-a-0-g-l-protein-level
#18
C Trouve, F Le Meunier, F Solomalalarivelo, X Delentaigne Delogivieres, M Drouard, R Suguenot, E Lecuyer, H Bentayeb, I Rault, Y Douadi, C Dayen
No abstract text is available yet for this article.
May 2015: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/25888297/antinociceptive-effect-of-methanol-extract-of-leaves-of-persicaria-hydropiper-in-mice
#19
Ambia Khatun, Mohammad Zafar Imam, Md Sohel Rana
BACKGROUND: Persicaria hydropiper (Linn.) Delarbre is a common plant of Polygonaceae family commonly called Bishkatali in Bangladesh. Leaves of the plant are traditionally used in the treatment of rheumatic pain, gout, and skin diseases such as ringworms, scabies, boils, abscesses, carbuncles, bites of snakes, dogs or insects. This study evaluated the antinociceptive effect of the methanol extract of P. hydropiper leaves (MEPH). METHODS: The antinociceptive activity of MEPH was investigated using heat-induced (hot-plate and tail-immersion test) and chemical-induced (acetic acid, formalin, glutamic acid, cinnamaldehyde) nociception models in mice at 25, 50, and 75 mg/kg doses...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25856706/the-antinociceptive-effects-of-magnesium-sulfate-and-mk-801-in-visceral-inflammatory-pain-model-the-role-of-no-cgmp-k-atp-pathway
#20
Sonja Vuckovic, Dragana Srebro, Katarina Savic Vujovic, Milica Prostran
CONTEXT: Magnesium and MK-801 (dizocilpine), antagonists of N-methyl-d-aspartate receptors, are involved in the processing of pain. OBJECTIVE: This study determines whether magnesium sulfate (MS) and MK-801 affects visceral inflammatory pain and determines a possible mechanism of action. MATERIALS AND METHODS: Analgesic activity was assessed using the acetic acid-induced writhing test in rats. MS (1-45 mg/kg) or MK-801 (0.005-0.03 mg/kg) was administrated subcutaneously (s...
2015: Pharmaceutical Biology
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