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methylene blue analgesic

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https://www.readbyqxmd.com/read/27687351/new-technique-targeting-the-c5-nerve-root-proximal-to-the-traditional-interscalene-sonoanatomical-approach-is-analgesic-for-outpatient-arthroscopic-shoulder-surgery
#1
Katherine H Dobie, Yaping Shi, Matthew S Shotwell, Warren S Sandberg
STUDY OBJECTIVE: Regional anesthesia and analgesia for shoulder surgery is most commonly performed via interscalene nerve block. We developed an ultrasound-guided technique that specifically targets the C5 nerve root proximal to the traditional interscalene block and assessed its efficacy for shoulder analgesia. DESIGN: Prospective case series. SETTING: Vanderbilt Bone and Joint Surgery Center. PATIENTS: Patients undergoing shoulder arthroscopy at an ambulatory surgery center...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27651809/effects-of-topical-and-systemic-administration-of-eugenia-caryophyllata-buds-essential-oil-on-corneal-anesthesia-and-analgesia
#2
Emad Khalilzadeh, Reza Hazrati, Gholamreza Vafaei Saiah
Clinical studies suggest that essential oil of Eugenia caryophyllata (Clove) buds (EOEC) is efficacious in the treatment of dental pain. In the present study, we investigated the analgesic and local anesthetic effects of EOEC and its possible mechanisms of action in acute corneal pain in rats. EOEC was extracted by hydro-distillation in a Clevenger type apparatus from clove buds. The acute corneal pain was induced by applying a drop (40 µl) of 5 M NaCl solution on the corneal surface, and the numbers of eye wipes were counted during the first 30 s...
July 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26590962/efficacy-and-cost-effectiveness-of-intradiscal-methylene-blue-injection-for-chronic-discogenic-low-back-pain-study-protocol-for-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
José W Geurts, Jan-Willem Kallewaard, Alfons Kessels, Paul C Willems, Henk van Santbrink, Carmen Dirksen, Maarten van Kleef
BACKGROUND: Low back pain (LBP) is a common health problem and a substantial part of LBP is presumed to be attributable to degeneration of the intervertebral disc. For patients suffering from intractable discogenic LBP, there are few evidence-based effective interventional treatment options available. In 2010, the results of a randomized controlled trial (RCT) were published concerning "intradiscal methylene blue injection" (IMBI), in which this intervention appeared to be very successful in relieving discogenic pain...
2015: Trials
https://www.readbyqxmd.com/read/26213475/evaluation-of-the-protein-biomarkers-and-the-analgesic-response-to-systemic-methylene-blue-in-patients-with-refractory-neuropathic-pain-a-double-blind-controlled-study
#4
Adriana A Miclescu, Martin Svahn, Torsten E Gordh
AIM: This study was carried out in patients with neuropathic pain in order to assess the analgesic effects and changes in protein biomarkers after the administration of methylene blue (MB), a diaminophenothiazine with antioxidant and anti-inflammatory properties, and with inhibitory effects on nitric oxide. MATERIALS AND METHODS: Ten patients with chronic refractory neuropathic pain were randomized to receive either MB (10 mg/mL Methylthioninium chloride) 2 mg/kg (MB group) or MB 0...
2015: Journal of Pain Research
https://www.readbyqxmd.com/read/26204654/the-effects-of-riboflavin-and-methylene-blue-on-nociception-and-visceral-pain
#5
A Luca, Teodora Alexa, A Dondaş, Irina-Mihaela Crăcană, Magda Bădescu, Cătălina Bohotin
BACKGROUND: Methylene Blue (MB) can prevent electron leaking, increase mitochondrial oxidative phosphorylation, and reduce ROS overproduction under pathological conditions, currently being trace evidence that it can alter pain perception in humans by local administration during certain surgical procedures. Riboflavin or vitamin B2 (B2) constitutes a part of the vitamin B group, which in recent studies shows a growing implication in the treatment of some pathology that imply pain management...
April 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/26072010/-a-pleural-transudate-with-a-0-g-l-protein-level
#6
C Trouve, F Le Meunier, F Solomalalarivelo, X Delentaigne Delogivieres, M Drouard, R Suguenot, E Lecuyer, H Bentayeb, I Rault, Y Douadi, C Dayen
No abstract text is available yet for this article.
May 2015: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/25888297/antinociceptive-effect-of-methanol-extract-of-leaves-of-persicaria-hydropiper-in-mice
#7
Ambia Khatun, Mohammad Zafar Imam, Md Sohel Rana
BACKGROUND: Persicaria hydropiper (Linn.) Delarbre is a common plant of Polygonaceae family commonly called Bishkatali in Bangladesh. Leaves of the plant are traditionally used in the treatment of rheumatic pain, gout, and skin diseases such as ringworms, scabies, boils, abscesses, carbuncles, bites of snakes, dogs or insects. This study evaluated the antinociceptive effect of the methanol extract of P. hydropiper leaves (MEPH). METHODS: The antinociceptive activity of MEPH was investigated using heat-induced (hot-plate and tail-immersion test) and chemical-induced (acetic acid, formalin, glutamic acid, cinnamaldehyde) nociception models in mice at 25, 50, and 75 mg/kg doses...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25856706/the-antinociceptive-effects-of-magnesium-sulfate-and-mk-801-in-visceral-inflammatory-pain-model-the-role-of-no-cgmp-k-atp-pathway
#8
Sonja Vuckovic, Dragana Srebro, Katarina Savic Vujovic, Milica Prostran
CONTEXT: Magnesium and MK-801 (dizocilpine), antagonists of N-methyl-d-aspartate receptors, are involved in the processing of pain. OBJECTIVE: This study determines whether magnesium sulfate (MS) and MK-801 affects visceral inflammatory pain and determines a possible mechanism of action. MATERIALS AND METHODS: Analgesic activity was assessed using the acetic acid-induced writhing test in rats. MS (1-45 mg/kg) or MK-801 (0.005-0.03 mg/kg) was administrated subcutaneously (s...
2015: Pharmaceutical Biology
https://www.readbyqxmd.com/read/25658740/phytochemical-composition-and-antinociceptive-activity-of-bauhinia-glauca-subsp-hupehana-in-rats
#9
Jinlong Xu, Qizhi Zhao, Lei Wei, Yu Yang, Rui Xu, Nengjiang Yu, Yimin Zhao
In traditional medicine, Bauhinia glauca subsp. hupehana has long been used as an analgesic agent in China. The aim of this study was to evaluate the antinociceptive activity of the ethanol extract of the aerial parts of B. glauca subsp. hupehana (BHE) in rats and its chemical fingerprint. The antinociceptive activity of BHE was assessed in mice using chemically and heat-induced pain models, such as the acetic acid-induced writhing, hot plate, tail-flick and glutamate tests. Naltrexone hydrochloride, a non-selective opioid receptor antagonist, was utilized to determine the involvement of the opioid system...
2015: PloS One
https://www.readbyqxmd.com/read/25504952/mechanisms-of-%C3%AE-mangostin-induced-antinociception-in-a-rodent-model
#10
Mohd Hijaz Mohd Sani, Muhammad Taher, Deny Susanti, Teh Lay Kek, Mohd Zaki Salleh, Zainul Amiruddin Zakaria
OBJECTIVE: Elucidate the antinociceptive mechanisms of α-mangostin isolated from Garcinia malaccensis Linn. METHODS: Male mice/rats (n = 6/group) were used in this between-group study. To determine α-mangostin's antinociceptive profile, animals were given α-mangostin orally (3, 30, or 100 mg/kg) 60 min before the start of the abdominal constriction or formalin tests. In the hot plate test, the noxious stimulus was applied before and 60, 90, 120, 150, 180, and 210 min after treatment with test solutions...
January 2015: Biological Research for Nursing
https://www.readbyqxmd.com/read/25449407/trpa1-nmda-receptors-and-nitric-oxide-mediate-mechanical-hyperalgesia-induced-by-local-injection-of-magnesium-sulfate-into-the-rat-hind-paw
#11
Dragana P Srebro, Sonja M Vučković, Katarina R Savić Vujović, Milica Š Prostran
Previous studies have shown that while magnesium, an antagonist of the glutamate subtype of N-methyl-D-aspartate receptors, possesses analgesic properties, it can induce writhing in rodents. The aim of this study was to determine the effect and mechanism of action of local (intraplantar) administration of magnesium sulfate (MS) on the paw withdrawal threshold (PWT) to mechanical stimuli. The PWT was evaluated by the electronic von Frey test in male Wistar rats. Tested drugs were either co-administered intraplantarly (i...
February 2015: Physiology & Behavior
https://www.readbyqxmd.com/read/25286607/-clinical-anatomic-ground-of-caudal-approach-in-newborns-with-surgical-pathology
#12
M Iu Kurochkin
Anatomic research have been done on 20 dead bodies of newborns for updating of caudal block level. For definition of caudal block level it was proved, that injection of coloring agent in volume of 0.5 ml/kg, 1 ml/kg and 1.2 ml/kg promotes reaching middle thoracic, high thoracic and highest level of epidural block. Analysis of hemodynamic and serum cortisol level in 25 newborns with surgical pathology showed the best analgesic effect in 15 newborns, who have got caudal-epidural anesthesia comparably with 10 newborns, who have got traditional multicomponent general anesthesia...
March 2014: Likars'ka Sprava
https://www.readbyqxmd.com/read/25278343/involvement-of-l-arginine-no-cgmp-k-atp-channel-pathway-in-the-peripheral-antinociceptive-actions-of-ellagic-acid-in-the-rat-formalin-test
#13
Behnam Ghorbanzadeh, Mohammad Taghi Mansouri, Ali Asghar Hemmati, Bahareh Naghizadeh, Seyyed Ali Mard, Anahita Rezaie
The present study was conducted to evaluate the local antinociceptive actions of EA and the possible involvement of l-arginine/NO/cGMP/KATP channel pathway in this effect using formalin test in rats. To evaluate the involvement of l-arginine/NO/cGMP/KATP channel pathway in the antinociceptive action of EA, rats were pre-treated intraplantarlly with l-NAME (NOS inhibitor, 25-100μg/paw), methylene blue (guanylyl cyclase inhibitor, 100-400μg/paw), glibenclamide (ATP-sensitive K(+) channel blocker, 25-100μg/paw), l-arginine (a nitric oxide precursor, 25-100μg/paw) and sodium nitroprusside (125-500μg/paw)...
November 2014: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/25142022/targeting-mitochondria-with-methylene-blue-protects-mice-against-acetaminophen-induced-liver-injury
#14
Kang Kwang Lee, Naoki Imaizumi, Sally R Chamberland, Nathan N Alder, Urs A Boelsterli
UNLABELLED: Acetaminophen (APAP) overdose is a frequent cause of drug-induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed that impairment of mitochondrial respiration is an early event in the pathogenesis, but the exact mechanisms have remained unclear, and therapeutic approaches to specifically target mitochondria have been insufficiently explored. Here, we found that the reactive oxidative metabolite of APAP, N-acetyl-p-benzoquinoneimine (NAPQI), caused the selective inhibition of mitochondrial complex II activity by >90% in both mouse hepatic mitochondria and yeast-derived complexes reconstituted into nanoscale model membranes, as well as the decrease of succinate-driven adenosine triphosphate (ATP) biosynthesis rates...
January 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/24661967/antinociceptive-effect-of-ethanol-extract-of-leaves-of-lannea-coromandelica
#15
Mohammad Zafar Imam, Md Moniruzzaman
ETHNOPHARMACOLOGICAL RELEVANCE: Lannea coromandelica (Houtt.) Merr. is a plant locally called "Jiga", found all over Bangladesh. Leaf of the plant is traditionally used in the treatment of local swellings, pains of body, toothache etc. This study evaluated the antinociceptive effect of the ethanol extract of L. coromandelica leaves (EELC). MATERIALS AND METHODS: The antinociceptive activity of the extract (at the doses of 50, 100, and 200 mg/kg) was evaluated by using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate test...
May 28, 2014: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/24506265/randomized-single-blind-clinical-trial-of-intradermal-methylene-blue-on-pain-reduction-after-open-diathermy-haemorrhoidectomy
#16
RANDOMIZED CONTROLLED TRIAL
H-L Sim, K-Y Tan
BACKGROUND: Open haemorrhoidectomy has been associated with considerable postoperative pain and discomfort. Perianal intradermal injection of methylene blue has been shown to ablate perianal nerve endings and may bring about temporary pain relief after haemorrhoidectomy. We hypothesized that the administration of intradermal methylene blue would reduce postoperative pain during the initial period after surgery. METHOD: A randomized, prospective, single-blind placebo-controlled trial was conducted...
August 2014: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/24464921/ultrasound-guided-block-of-sciatic-and-femoral-nerves-an-anatomical-study
#17
Sonja Waag, Michael H Stoffel, Claudia Spadavecchia, Urs Eichenberger, Helene Rohrbach
The sheep is a popular animal model for human biomechanical research involving invasive surgery on the hind limb. These painful procedures can only be ethically justified with the application of adequate analgesia protocols. Regional anaesthesia as an adjunct to general anaesthesia may markedly improve well-being of these experimental animals during the postoperative period due to a higher analgesic efficacy when compared with systemic drugs, and may therefore reduce stress and consequently the severity of such studies...
April 2014: Laboratory Animals
https://www.readbyqxmd.com/read/24289087/antinociceptive-activity-of-a-synthetic-oxopyrrolidine-based-compound-ash21374-and-determination-of-its-possible-mechanisms
#18
Zainul Amiruddin Zakaria, Mohammed Hijaz Sani, Mohammed Fazli Mohammat, Nurul Shulehaf Mansor, Zurina Shaameri, Teh Lay Kek, Mohd Zaki Salleh, Ahmad Sazali Hamzah
This study was carried out to determine the antinociceptive activity of a novel synthetic oxopyrrolidine-based compound, (2R,3R,4S)-ethyl 4-hydroxy-1,2-dimethyl-5-oxopyrrolidine-3-carboxylate (ASH21374), and to elucidate the involvement of the opioid, vanilloid, glutamate, and nitric oxide - cyclic guanosine monophosphate (NO/cGMP) systems in modulating the observed antinociception. ASH21374, in the doses of 2, 10, and 100 mg/kg body mass, was administered orally to mice 60 mins prior to exposure to various antinociceptive assays...
December 2013: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/24280010/chaperone-heat-shock-protein-70-in-nucleus-accumbens-core-a-novel-biological-target-of-behavioural-sensitization-to-morphine-in-rats
#19
Yan-Ting Wang, Wang-Jun Qin, Qing Liu, Yu-Ling Li, Hui Liang, Feng Chen, Andrew J Lawrence, Xiang-Lin Zhang, Jian-Hui Liang
Drug addiction is a major public health issue, yet the underlying adaptation of neural networks by drugs of abuse is not fully understood. We have previously linked chaperone heat shock protein 70 (Hsp70) to drug-induced adaptations. Focusing on the NAc core and shell, the present study aims to provide further findings for our understanding of the relation between behavioural sensitization to morphine and Hsp70 at transcriptional and functional levels in rats. Firstly, we delineated the characteristics of behavioural sensitization induced by a single morphine exposure (1-10 mg/kg, s...
March 2014: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/23859109/-methaemoglobinaemia-after-using-emla-cream
#20
Jasper L Selder, Jan Veenstra
BACKGROUND: The use of creams is considered to be generally safe. However, systemic side effects can occur. CASE DESCRIPTION: A 22-year-old woman came to the emergency department with dyspnea, confusion and 'blue' skin after laser treatment of the upper legs for excessive hair. She had used three tubes of a eutectic mixture of local anaesthetics (EMLA) cream containing lidocaine/prilocaine for analgesia. Her oxygen saturation was 87%, measured with pulse oximetry...
2013: Nederlands Tijdschrift Voor Geneeskunde
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