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https://www.readbyqxmd.com/read/29320436/the-feasibility-and-usability-of-runningcoach-a-remote-coaching-system-for-long-distance-runners
#1
Daniel Aranki, Gao Xian Peh, Gregorij Kurillo, Ruzena Bajcsy
Studies have shown that about half of the injuries sustained during long-distance running involve the knee. Cadence (steps per minute) has been identified as a factor that is strongly associated with these running-related injuries, making it a worthwhile candidate for further study. As such, it is critical for long-distance runners to minimize their risk of injury by running at an appropriate running cadence. In this paper, we present the results of a study on the feasibility and usability of RunningCoach, a mobile health (mHealth) system that remotely monitors running cadence levels of runners in a continuous fashion, among other variables, and provides immediate feedback to runners in an effort to help them optimize their running cadence...
January 10, 2018: Sensors
https://www.readbyqxmd.com/read/29313215/association-of-mitochondrial-dna-content-in-peripheral-blood-with-cancer-related-fatigue-and-chemotherapy-related-cognitive-impairment-in-early-stage-breast-cancer-patients-a-prospective-cohort-study
#2
Jung-Woo Chae, Peh Siang Chua, Terence Ng, Angie Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Sreemanee Dorajoo, Koon Mian Foo, Kiley Wei-Jen Loh, Si-Lin Koo, Wen Yee Chay, Tira Jing Ying Tan, Sok Yuen Beh, Elaine Hsuen Lim, Guek Eng Lee, Rebecca Dent, Yoon Sim Yap, Raymond Ng, Han Kiat Ho, Alexandre Chan
PURPOSE: Cancer-related fatigue (CRF) and chemotherapy-related cognitive impairment (CRCI) are reported to be associated with mitochondrial dysfunction. Hence, mitochondrial DNA (mtDNA) content, a biomarker of mitochondrial dysfunction, is hypothesized to correlate with the onset of CRF and CRCI. This study aims to evaluate the association between peripheral blood mtDNA content reduction and severity of CRF and CRCI in patients receiving chemotherapy. METHODS: This was a prospective cohort study...
January 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29239982/postexercise-hypotension-and-heart-rate-variability-responses-subsequent-to-traditional-paired-set-and-superset-training-methods
#3
Gabriel A Paz, Eliseo Iglesias-Soler, Jeffrey M Willardson, Marianna de Freitas Maia, Humberto Miranda
The purpose of this study was to compare training volume, post-exercise hypotension (PEH) and heart rate variability (HRV) responses to different strength training methods. Thirteen trained men volunteered for this study. Three training methods were completed in a randomized design, which included: Traditional Set (TS) - three successive sets for the lying bench press (LBP), lat pulldown (LPD), incline 45° bench press (BP45), seated close-grip row (SCR), triceps extension (TE), and biceps curl (BC), with a 90 sec...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239730/directed-differentiation-of-periocular-mesenchyme-from-human-embryonic-stem-cells
#4
Matthew Lovatt, Gary Hin-Fai Yam, Gary S Peh, Alan Colman, N Ray Dunn, Jodhbir S Mehta
Corneal tissue is the most transplanted of all body tissues. Currently, cadaveric donor tissues are used for transplantation. However, a global shortage of transplant grade material has prompted development of alternative, cell-based therapies for corneal diseases. Pluripotent stem cells are attractive sources of cells for regenerative medicine, because large numbers of therapeutically useful cells can be generated. However, a detailed understanding of how to differentiate clinically relevant cell types from stem cells is fundamentally required...
November 16, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29237144/robotic-assisted-simultaneous-repair-of-paraesophageal-hernia-and-morgagni-hernia-technical-report
#5
Shawn S Fu, Melissa M Carton, Iman Ghaderi, Carlos A Galvani
Morgagni hernias are a rare form of congenital diaphragmatic hernia, accounting for 2%-3% of cases. The presence of a simultaneous Morgagni hernia and paraesophageal hernia (PEH) is even more rare, with only a few reported cases in the surgical literature. Both open and laparoscopic surgical approaches have been previously described. Herein we discuss a robotic-assisted surgical approach to the repair of simultaneous Morgagni hernia and PEH in a 65-year-old woman. Simultaneous repair of Morgagni hernia and PEH is indicated mainly when symptoms are generally indistinctive...
December 13, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29230420/glycaemic-control-after-metformin-discontinuation-in-diabetic-patients-with-a-declining-renal-function
#6
Theresa Leyco, Davin Ryanputra, Ray Peh, Alexphil Ponce, Chin Meng Khoo
Metformin is contraindicated in diabetic patients with declining renal function. This study examined the glycaemic control in diabetic patients with chronic kidney disease when metformin was discontinued. This was a retrospective study. We screened 2032 diabetic patients who attended the Diabetes Clinic at a tertiary hospital between 1 September 2014 and 30 September 2015. We analyzed the data on 69 patients whom metformin was discontinued due to declining renal function and had a complete 6-month follow-up...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29227294/immediate-and-24-h-blood-pressure-lowering-effects-of-arm-crank-exercise-in-patients-with-traumatic-lower-limb-amputation-a-randomized-cross-over-study
#7
Marcelle Paula-Ribeiro, Daniel G Martinez, Jorge R P Lima, Mateus C Laterza
AIM: This study aimed to investigate the clinic and 24-h postexercise hypotension (PEH) after a moderate-intensity arm crank exercise session in individuals with traumatic lower-limb amputation. PARTICIPANTS AND METHODS: Nine men (46±17 years) with unilateral traumatic lower-limb amputation participated in two experimental sessions conducted randomly: an aerobic exercise (EXE: arm crank ergometer, 30 min) or a control session (CON: participants remained seated on the cycle ergometer, 30 min)...
December 8, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29201608/toward-bioelectronic-medicine-neuromodulation-of-small-peripheral-nerves-using-flexible-neural-clip
#8
Sanghoon Lee, Wendy Yen Xian Peh, Jiahui Wang, Fengyuan Yang, John S Ho, Nitish V Thakor, Shih-Cheng Yen, Chengkuo Lee
Neural modulation technology and the capability to affect organ function have spawned the new field of bioelectronic medicine. Therapeutic interventions depend on wireless bioelectronic neural interfaces that can conformally and easily attach to small (few hundred micrometers) nerves located deep in the body without neural damage. Besides size, factors like flexibility and compliance to attach and adapt to visceral nerves associated moving organs are of paramount importance and have not been previously addressed...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29201606/a-3d-printed-implantable-device-for-voiding-the-bladder-using-shape-memory-alloy-sma-actuators
#9
Faezeh Arab Hassani, Wendy Yen Xian Peh, Gil Gerald Lasam Gammad, Roshini Priya Mogan, Tze Kiat Ng, Tricia Li Chuen Kuo, Lay Guat Ng, Percy Luu, Shih-Cheng Yen, Chengkuo Lee
Underactive bladder or detrusor underactivity (DU) is defined as a reduction of contraction strength or duration of the bladder wall. Despite the serious healthcare implications of DU, there are limited solutions for affected individuals. A flexible 3D printed implantable device driven by shape memory alloys (SMA) actuators is presented here for the first time to physically contract the bladder to restore voluntary control of the bladder for individuals suffering from DU. This approach is used initially in benchtop experiments with a rubber balloon acting as a model for the rat bladder to verify its potential for voiding, and that the operating temperatures are safe for the eventual implantation of the device in a rat...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29184050/a-rare-case-of-bochdalek-hernia-with-concomitant-para-esophageal-hernia-repaired-laparoscopically-in-an-octogenarian
#10
Sergio Susmallian, Asnat Raziel
BACKGROUND A Bochdalek hernia (BH) is a rare congenital condition consisting of a posterolateral defect in the diaphragm. A para-esophageal hernia (PEH) is a rare variant of hiatus hernia. BH and PEH may present with gastric volvulus or incarceration, requiring emergency treatment. Minimally invasive surgery is the preferred treatment, particularly for elderly patients and patients with comorbidities. The occurrence of BH with concomitant PEH is a very rare event. We describe a case of an octogenarian patient with BH and concomitant PEH treated laparoscopically...
November 29, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29180482/deep-targeted-sequencing-of-endothelial-nitric-oxide-synthase-gene-exons-uncovers-exercise-intensity-and-ethnicity-dependent-associations-with-post-exercise-hypotension
#11
Linda S Pescatello, Elizabeth D Schifano, Garrett I Ash, Gregory A Panza, Lauren M L Corso, Ming-Hui Chen, Ved Deshpande, Amanda Zaleski, Burak Cilhoroz, Paulo Farinatti, Beth A Taylor, Rachel J O'Neill, Paul D Thompson
In previous studies, we found an endothelial nitric oxide synthase gene (NOS3) variant rs2070744 associated with the ambulatory blood pressure (BP) response following bouts of moderate and vigorous intensity acute exercise, termed post-exercise hypotension (PEH). In a validation cohort, we sequenced NOS3 exons for associations with PEH Obese (30.9 ± 3.6 kg.m-2) African American (n = 14) [AF] and Caucasian (n = 9) adults 42.0 ± 9.8 years with hypertension (139.8 ± 10.4/84.6 ± 6.2 mmHg) performed three random experiments: bouts of vigorous and moderate intensity cycling and control...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29162971/long-term-patient-reported-outcomes-of-paraesophageal-hernia-repair
#12
Damien J Lazar, Desmond H Birkett, David M Brams, Heather A Ford, Christina Williamson, Dmitry Nepomnayshy
Background and Objectives: There is a lack of consensus on the optimal repair technique and the definition of good outcomes in paraesophageal hernia (PEH) repair. We reviewed long-term patient-reported outcomes of open and laparoscopic PEH repair to assist with our future surgical consent process. Methods: This was a retrospective case-control study including all patients with PEH repair performed from 2000 through 2012 at a single center without the use of mesh...
October 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29142250/loss-of-lamin-b1-is-a-biomarker-to-quantify-cellular-senescence-in-photoaged-skin
#13
Audrey Shimei Wang, Peh Fern Ong, Alexandre Chojnowski, Carlos Clavel, Oliver Dreesen
Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by senescence associated-β-galactosidase (SA-β-gal) staining, a procedure that requires enzymatic activity, which is lost in fixed tissue samples. We previously demonstrated that loss of lamin B1 is a novel marker to identify senescent cells...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141897/effects-of-health-and-social-care-spending-constraints-on-mortality-in-england-a-time-trend-analysis
#14
Johnathan Watkins, Wahyu Wulaningsih, Charlie Da Zhou, Dominic C Marshall, Guia D C Sylianteng, Phyllis G Dela Rosa, Viveka A Miguel, Rosalind Raine, Lawrence P King, Mahiben Maruthappu
OBJECTIVE: Since 2010, England has experienced relative constraints in public expenditure on healthcare (PEH) and social care (PES). We sought to determine whether these constraints have affected mortality rates. METHODS: We collected data on health and social care resources and finances for England from 2001 to 2014. Time trend analyses were conducted to compare the actual mortality rates in 2011-2014 with the counterfactual rates expected based on trends before spending constraints...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29130015/jejunal-diverticular-perforation-causing-small-bowel-obstruction-in-a-type-4-hiatal-hernia-a-rare-case-report-of-a-nonagenarian-patient-and-review-of-relevant-literature
#15
Saptarshi Biswas, Shekhar Gogna, Prem Patel
Type IV paraesophageal hernia (PEH) is very rare and is characterized by the intrathoracic herniation of the abdominal viscera other than the stomach into the chest. We describe a case of a 90-year-old male patient who presented at our emergency department complaining of epigastric pain that he had experienced over the past few hours and getting progressively worse. On the day after admission, his pain became severe. Chest radiography revealed an intrathoracic intestinal gas bubble; emergency exploratory laparotomy identified a type IV PEH with herniation of only the jejunum with perforated diverticula on mesenteric side through a hiatal defect into mediastinum...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29123364/corneal-lenticule-storage-before-reimplantation
#16
Yu-Chi Liu, Geraint P Williams, Ben L George, Yu Qiang Soh, Xin Yi Seah, Gary Swee Lim Peh, Gary Hin Fai Yam, Jodhbir S Mehta
Purpose: To explore the optimal lenticule storage conditions that maintain lenticule integrity and clarity. Methods: A total of 99 lenticules obtained from myopic patients undergoing small incision lenticule extraction (SMILE) were divided into four combinations for short-term storage conditions: PBS, Dulbecco's Modified Eagle's Medium (DMEM), Optisol GS, or anhydrous glycerol. Two thirds of the lenticules were further stored for 4 weeks under eight different conditions...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29120987/continuous-and-accumulated-bouts-of-cycling-matched-by-intensity-and-energy-expenditure-elicit-similar-acute-blood-pressure-reductions-in-prehypertensive-men
#17
Guilherme F Fonseca, Paulo T V Farinatti, Adrian W Midgley, Arthur Ferreira, Tainah de Paula, Walace D Monteiro, Felipe A Cunha
Fonseca, GF, Farinatti, PTV, Midgley, AW, Ferreira, A, de Paula, T, Monteiro, WD, and Cunha, FA. Continuous and accumulated bouts of cycling matched by intensity and energy expenditure elicit similar acute blood pressure reductions in prehypertensive men. J Strength Cond Res XX(X): 000-000, 2017-This study investigated differences in postexercise hypotension (PEH) after continuous vs. accumulated isocaloric bouts of cycling. Ten prehypertensive men, aged 23-34 years, performed 2 bouts of cycling at 75% oxygen uptake reserve, with total energy expenditures of 400 kcal per bout...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29104494/pathogenic-role-of-exosomes-in-epstein-barr-virus-ebv-associated-cancers
#18
REVIEW
Sin-Yeang Teow, Kitson Liew, Alan Soo-Beng Khoo, Suat-Cheng Peh
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29098213/single-cell-analysis-of-early-antiviral-gene-expression-reveals-a-determinant-of-stochastic-ifnb1-expression
#19
Sultan Doğanay, Maurice Youzong Lee, Alina Baum, Jessie Peh, Sun-Young Hwang, Joo-Yeon Yoo, Paul J Hergenrother, Adolfo García-Sastre, Sua Myong, Taekjip Ha
RIG-I-like receptors (RLRs) are cytoplasmic sensors of viral RNA that trigger the signaling cascade that leads to type I interferon (IFN) production. Transcriptional induction of RLRs by IFN is believed to play the role of positive feedback to further amplify viral sensing. We found that RLRs and several other IFN-stimulated genes (ISGs) are induced early in viral infection independent of IFN. Expression of these early ISGs requires IRF3/IRF7 and is highly correlated amongst them. Simultaneous detection of mRNA of IFNB1, viral replicase, and ISGs revealed distinct populations of IFNB1 expressing and non-expressing cells which are highly correlated with the levels of early ISGs but are uncorrelated with IFN-dependent ISGs and viral gene expression...
November 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29096114/surface-engineering-on-continuous-vo2-thin-films-to-improve-thermochromic-properties-top-down-acid-etching-and-bottom-up-self-patterning
#20
Ning Wang, Yew Keat Peh, Shlomo Magdassi, Yi Long
Surface engineering is an effective method to improve the thermochromic performance of VO2. In this paper, an acid-etching top down method was proposed to tailor the VO2 surface morphology from the continuous dense-packed surface to patterned structure, which exhibited the enhanced integrated visible transmittance (Tlum) and the enlarged solar modulating abilities (ΔTsol). Moreover, a self-patterning approach was also illustrated to improve the thermochromic properties. The proposed surface engineering methods represent a facile and cost-effective approach for enhancing thermochromic properties that could promote the application of VO2 thin films in smart windows...
October 30, 2017: Journal of Colloid and Interface Science
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