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https://www.readbyqxmd.com/read/29142250/loss-of-lamin-b1-is-a-biomarker-to-quantify-cellular-senescence-in-photoaged-skin
#1
Audrey Shimei Wang, Peh Fern Ong, Alexandre Chojnowski, Carlos Clavel, Oliver Dreesen
Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by senescence associated-β-galactosidase (SA-β-gal) staining, a procedure that requires enzymatic activity, which is lost in fixed tissue samples. We previously demonstrated that loss of lamin B1 is a novel marker to identify senescent cells...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141897/effects-of-health-and-social-care-spending-constraints-on-mortality-in-england-a-time-trend-analysis
#2
Johnathan Watkins, Wahyu Wulaningsih, Charlie Da Zhou, Dominic C Marshall, Guia D C Sylianteng, Phyllis G Dela Rosa, Viveka A Miguel, Rosalind Raine, Lawrence P King, Mahiben Maruthappu
OBJECTIVE: Since 2010, England has experienced relative constraints in public expenditure on healthcare (PEH) and social care (PES). We sought to determine whether these constraints have affected mortality rates. METHODS: We collected data on health and social care resources and finances for England from 2001 to 2014. Time trend analyses were conducted to compare the actual mortality rates in 2011-2014 with the counterfactual rates expected based on trends before spending constraints...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29130015/jejunal-diverticular-perforation-causing-small-bowel-obstruction-in-a-type-4-hiatal-hernia-a-rare-case-report-of-a-nonagenarian-patient-and-review-of-relevant-literature
#3
Saptarshi Biswas, Shekhar Gogna, Prem Patel
Type IV paraesophageal hernia (PEH) is very rare and is characterized by the intrathoracic herniation of the abdominal viscera other than the stomach into the chest. We describe a case of a 90-year-old male patient who presented at our emergency department complaining of epigastric pain that he had experienced over the past few hours and getting progressively worse. On the day after admission, his pain became severe. Chest radiography revealed an intrathoracic intestinal gas bubble; emergency exploratory laparotomy identified a type IV PEH with herniation of only the jejunum with perforated diverticula on mesenteric side through a hiatal defect into mediastinum...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29123364/corneal-lenticule-storage-before-reimplantation
#4
Yu-Chi Liu, Geraint P Williams, Ben L George, Yu Qiang Soh, Xin Yi Seah, Gary Swee Lim Peh, Gary Hin Fai Yam, Jodhbir S Mehta
Purpose: To explore the optimal lenticule storage conditions that maintain lenticule integrity and clarity. Methods: A total of 99 lenticules obtained from myopic patients undergoing small incision lenticule extraction (SMILE) were divided into four combinations for short-term storage conditions: PBS, Dulbecco's Modified Eagle's Medium (DMEM), Optisol GS, or anhydrous glycerol. Two thirds of the lenticules were further stored for 4 weeks under eight different conditions...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29120987/continuous-and-accumulated-bouts-of-cycling-matched-by-intensity-and-energy-expenditure-elicit-similar-acute-blood-pressure-reductions-in-prehypertensive-men
#5
Guilherme F Fonseca, Paulo T V Farinatti, Adrian W Midgley, Arthur Ferreira, Tainah de Paula, Walace D Monteiro, Felipe A Cunha
Fonseca, GF, Farinatti, PTV, Midgley, AW, Ferreira, A, de Paula, T, Monteiro, WD, and Cunha, FA. Continuous and accumulated bouts of cycling matched by intensity and energy expenditure elicit similar acute blood pressure reductions in prehypertensive men. J Strength Cond Res XX(X): 000-000, 2017-This study investigated differences in postexercise hypotension (PEH) after continuous vs. accumulated isocaloric bouts of cycling. Ten prehypertensive men, aged 23-34 years, performed 2 bouts of cycling at 75% oxygen uptake reserve, with total energy expenditures of 400 kcal per bout...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29104494/pathogenic-role-of-exosomes-in-epstein-barr-virus-ebv-associated-cancers
#6
REVIEW
Sin-Yeang Teow, Kitson Liew, Alan Soo-Beng Khoo, Suat-Cheng Peh
Exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs (miRNAs). These nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. Exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. They contain various pathogenic factors whereby their adverse effects have been implicated in multiple viral infections and cancers...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29098213/single-cell-analysis-of-early-antiviral-gene-expression-reveals-a-determinant-of-stochastic-ifnb1-expression
#7
Sultan Doğanay, Maurice Youzong Lee, Alina Baum, Jessie Peh, Sun-Young Hwang, Joo-Yeon Yoo, Paul J Hergenrother, Adolfo García-Sastre, Sua Myong, Taekjip Ha
RIG-I-like receptors (RLRs) are cytoplasmic sensors of viral RNA that trigger the signaling cascade that leads to type I interferon (IFN) production. Transcriptional induction of RLRs by IFN is believed to play the role of positive feedback to further amplify viral sensing. We found that RLRs and several other IFN-stimulated genes (ISGs) are induced early in viral infection independent of IFN. Expression of these early ISGs requires IRF3/IRF7 and is highly correlated amongst them. Simultaneous detection of mRNA of IFNB1, viral replicase, and ISGs revealed distinct populations of IFNB1 expressing and non-expressing cells which are highly correlated with the levels of early ISGs but are uncorrelated with IFN-dependent ISGs and viral gene expression...
November 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29096114/surface-engineering-on-continuous-vo2-thin-films-to-improve-thermochromic-properties-top-down-acid-etching-and-bottom-up-self-patterning
#8
Ning Wang, Yew Keat Peh, Shlomo Magdassi, Yi Long
Surface engineering is an effective method to improve the thermochromic performance of VO2. In this paper, an acid-etching top down method was proposed to tailor the VO2 surface morphology from the continuous dense-packed surface to patterned structure, which exhibited the enhanced integrated visible transmittance (Tlum) and the enlarged solar modulating abilities (ΔTsol). Moreover, a self-patterning approach was also illustrated to improve the thermochromic properties. The proposed surface engineering methods represent a facile and cost-effective approach for enhancing thermochromic properties that could promote the application of VO2 thin films in smart windows...
October 30, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29095875/trajectories-of-positive-negative-and-general-psychopathology-symptoms-in-first-episode-psychosis-and-their-relationship-with-functioning-over-a-2-year-follow-up-period
#9
Edimansyah Abdin, Siow Ann Chong, Janhavi Ajit Vaingankar, Chao Xu Peh, Lye Yin Poon, Sujatha Rao, Swapna Verma, Mythily Subramaniam
BACKGROUND: Few studies have examined the trajectories of symptom severity in first episode psychosis (FEP) and their impact on functioning. This study aimed to identify discrete trajectories of positive, negative and general psychopathological symptoms and functioning, determine predictors of the identified symptom trajectories and subsequently investigate the relationship between symptom and functioning trajectories over the 2-year follow-up period. METHODS: Data were extracted from the Singapore Early Psychosis Intervention Programme clinical database...
2017: PloS One
https://www.readbyqxmd.com/read/29090299/effects-of-the-physical-form-and-the-degree-of-saturation-of-oil-on-postprandial-plasma-triglycerides-glycemia-and-appetite-of-healthy-chinese-adults
#10
Sze-Yen Tan, Elaine Peh, Phei Ching Siow, Alejandro G Marangoni, Christiani Jeyakumar Henry
Ethylcellulose (EC) forms a complex oleogel network that entraps lipids. The digestibility of an oleogel is influenced by the types of oils used in its preparation. This randomised, controlled, crossover study aimed to compare lipidemic, glycemic, and appetitive responses to a test meal alone (no oil control), or to palm oil (PO, 22.25 g), rice bran oil (RBO, 22.25 g), palm oleogel (PG, 22.25 g oil + 2.75 g EC), or rice bran oleogel (RBG, 22.25 g oil + 2.75 g EC). Eighteen healthy Chinese males (age: 28 ± 6 years, weight: 65...
November 1, 2017: Food & Function
https://www.readbyqxmd.com/read/29079706/genome-wide-association-study-identified-copy-number-variants-associated-with-sporadic-colorectal-cancer-risk
#11
Lai Fun Thean, Yee Syuen Low, Michelle Lo, Yik-Ying Teo, Woon-Puay Koh, Jian-Min Yuan, Min Hoe Chew, Choong Leong Tang, Peh Yean Cheah
BACKGROUND: Multiple single nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) risk. The role of structural or copy number variants (CNV) in CRC, however, remained unclear. We investigated the role of CNVs in patients with sporadic CRC. METHODS: A genome-wide association study (GWAS) was performed on 1000 Singapore Chinese patients aged 50 years or more with no family history of CRC and 1000 ethnicity-matched, age-matched and gender-matched healthy controls using the Affymetrix SNP 6 platform...
October 27, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29074873/regulatory-compliant-tissue-engineered-human-corneal-endothelial-grafts-restore-corneal-function-of-rabbits-with-bullous-keratopathy
#12
Gary S L Peh, Heng-Pei Ang, Chan N Lwin, Khadijah Adnan, Benjamin L George, Xin-Yi Seah, Shu-Jun Lin, Maninder Bhogal, Yu-Chi Liu, Donald T Tan, Jodhbir S Mehta
Corneal transplantation is the only treatment available to restore vision for individuals with blindness due to corneal endothelial dysfunction. However, severe shortage of available donor corneas remains a global challenge. Functional regulatory compliant tissue-engineered corneal endothelial graft substitute can alleviate this reliance on cadaveric corneal graft material. Here, isolated primary human corneal endothelial cells (CEnCs) propagated using a dual media approach refined towards regulatory compliance showed expression of markers indicative of the human corneal endothelium, and can be tissue-engineered onto thin corneal stromal carriers...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29069346/outbreak-of-invasive-infections-from-subtype-emm26-3-group-a-streptococcus-among-homeless-adults-anchorage-alaska-2016-2017
#13
Emily Mosites, Anna Frick, Prabhu Gounder, Louisa Castrodale, Yuan Li, Karen Rudolph, Debby Hurlburt, Kristen D Lecy, Tammy Zulz, Tolu Adebanjo, Jennifer Onukwube, Bernard Beall, Chris A Van Beneden, Thomas Hennessy, Joseph McLaughlin, Bruce Michael
Background: In 2016, we detected an outbreak of group A Streptococcus (GAS) invasive infections among the estimated 1000 persons experiencing homelessness (PEH) in Anchorage, Alaska. We characterized the outbreak and implemented a mass antibiotic intervention at homeless service facilities. Methods: We identified cases through the Alaska GAS laboratory-based surveillance system. We conducted emm-typing, antimicrobial susceptibility testing, and whole genome sequencing (WGS) on all invasive isolates and compared medical record data of patients infected with emm26...
October 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018769/homeless-shelter-context-and-tuberculosis-illness-experiences-during-a-large-outbreak-in-atlanta-georgia
#14
W J Connors, S A Hussen, D P Holland, O Mohamed, K L Andes, N D Goswami
Setting: Persons experiencing homelessness (PEH) represent a population at high risk for tuberculosis (TB). While quantitative studies have characterized some important features of this key group, less has been captured directly from PEH about how they experience TB illness itself and the prevention and control measures implemented in response to an outbreak. This qualitative study aimed to explore PEH's TB disease experiences in the context of a large TB outbreak involving homeless shelters in Atlanta, Georgia, USA...
September 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/28985278/post-exercise-hypotension-after-aquatic-exercise-in-older-women-with-hypertension-a-randomized-crossover-clinical-trial
#15
R M Cunha, A M Costa, C N F Silva, T I Rolim, L S Pescatello, A M Lehnen
Background: Hypertension can be prevented and modified with lifestyle interventions that include regular exercise. Aquatic exercise is widely recommended for older adults for a variety of health benefits, but few studies have assessed the immediate ambulatory blood pressure (BP) response to aquatic exercise, a response termed post-exercise hypotension (PEH). Thus, we assessed PEH after a session of aquatic exercise in physically active, older women with hypertension. Methods: Twenty-four women 70...
September 7, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28977017/real-time-assessment-of-corneal-endothelial-cell-damage-following-graft-preparation-and-donor-insertion-for-dmek
#16
Maninder Bhogal, Chan N Lwin, Xin-Yi Seah, Elavazhagan Murugan, Khadijah Adnan, Shu-Jun Lin, Gary Peh, Jodhbir S Mehta
PURPOSE: To establish a method for assessing graft viability, in-vivo, following corneal transplantation. METHODS: Optimization of calcein AM fluorescence and toxicity assessment was performed in cultured human corneal endothelial cells and ex-vivo corneal tissue. Descemet membrane endothelial keratoplasty grafts were incubated with calcein AM and imaged pre and post preparation, and in-situ after insertion and unfolding in a pig eye model. Global, macroscopic images of the entire graft and individual cell resolution could be attained by altering the magnification of a clinical confocal scanning laser microscope...
2017: PloS One
https://www.readbyqxmd.com/read/28976874/paraesophageal-hernia-as-a-cause-of-chronic-asymptomatic-anemia-in-a-6-years-old-boy-case-report-and-review-of-the-literature
#17
Dimitrios Patoulias, Maria Kalogirou, Thomas Feidantsis, Ignatios Kallergis, Ioannis Patoulias
Esophageal hiatal hernia is defined as the prolapse of one or more intra-abdominal organs through the esophageal hiatus. Four types are identified: type Ι or sliding hiatal hernia, type II or paraesophageal hernia (PEH), type III or mixed hernia and type IV. Congenital type II esophageal hiatal hernia is caused by a remaining gap after the formation of pleuroperitoneal membrane. We present a case of a six years old boy admitted to our department, appearing with asymptomatic anemia, who was incidentally diagnosed with Type II esophageal hiatal hernia...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28965176/influence-of-rice-pea-and-oat-proteins-in-attenuating-glycemic-response-of-sugar-sweetened-beverages
#18
Sze-Yen Tan, Phei Ching Siow, Elaine Peh, Christiani Jeyakumar Henry
PURPOSE: Liquids have higher ingestion and gastric-emptying rates, resulting in rapid glycemic response. They are also less satiating than solid foods. This study examined if the addition of plant proteins alter postprandial glucose, insulin, triglycerides, glucose-dependent insulinotropic peptide (GIP), glycogen-like peptide-1 (GLP-1) and appetitive responses to a sugar-sweetened beverage. METHODS: This was a randomized, crossover acute feeding study consisting of four treatments: chocolate beverage alone (50 g carbohydrate), or added with 24 g oat, pea or rice proteins...
September 30, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28959019/cd24-cd44-and-epcam-enrich-for-tumour-initiating-cells-in-a-newly-established-patient-derived-xenograft-of-nasopharyngeal-carcinoma
#19
Susan Ling Ling Hoe, Lu Ping Tan, Norazlin Abdul Aziz, Kitson Liew, Sin-Yeang Teow, Fazlyn Reeny Abdul Razak, Yoon Ming Chin, Nurul Ashikin Mohamed Shahrehan, Tai Lin Chu, Noor Kaslina Mohd Kornain, Suat-Cheng Peh, Cheng Eng Koay, Kwok-Wai Lo, Munirah Ahmad, Ching-Ching Ng, Alan Soo-Beng Khoo
Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the tumourigenic potential of CD24, CD44, EpCAM and combination of EpCAM/CD44 cells in NPC. CD44br and EpCAMbr cells enriched for higher S-phase cell content, faster-growing tumourigenic cells leading to tumours with larger volume and higher mitotic figures. Although CD44br and EpCAMbr cells significantly enriched for tumour-initiating cells (TICs), all cells could retain self-renewal property for at least four generations...
September 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922683/reproducibility-reliability-and-agreement-of-post-exercise-hypotension
#20
Rafael Yokoyama Fecchio, Marcel Chehuen, Leandro Campos Brito, Tiago Peçanha, Andréia Cristiane Carrenho Queiroz, Claudia Lucia de Moraes Forjaz
This study determined the reproducibility of post-exercise hypotension (PEH) calculated by the following methods: PEH_I=post-exercise BP - pre-exercise BP; PEH_II=post-exercise BP - post-control BP; and PEH_III=[(post-exercise BP - pre-exercise BP)-(post-control BP - pre-control BP)]. Twenty-five participants underwent four sessions divided in two blocks (test and retest). Each block consisted of one exercise and one control session. BP pressure was measured before and after the interventions. The presence of systematic error (paired t-tests), reliability [intraclass coefficient correlation (ICC)], and agreement [typical error (TE) and minimal detectable difference (MDD)] were evaluated...
September 18, 2017: International Journal of Sports Medicine
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