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https://www.readbyqxmd.com/read/28634161/oncolytic-adenovirus-expressing-bispecific-antibody-targets-t-cell-cytotoxicity-in-cancer-biopsies
#1
Joshua D Freedman, Joachim Hagel, Eleanor M Scott, Ioannis Psallidas, Avinash Gupta, Laura Spiers, Paul Miller, Nikolaos Kanellakis, Rebecca Ashfield, Kerry D Fisher, Margaret R Duffy, Leonard W Seymour
Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bispecific single-chain antibody, secreted from infected tumour cells into the microenvironment. This bispecific T-cell engager (BiTE) binds to EpCAM on target cells and cross-links them to CD3 on T cells, leading to clustering and activation of both CD4 and CD8 T cells. BiTE transcription can be controlled by the virus major late promoter, limiting expression to cancer cells that are permissive for virus replication...
June 20, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28622400/prevalence-of-malocclusion-and-distribution-of-occlusal-characteristics-in-13-to-18-year-old-adolescents-attending-selected-high-schools-in-the-municipality-of-san-juan-pr-2012-2013
#2
Karla Alvarado, Lydia López, Rosana Hanke, Francis Picón, Sona Rivas-Tumanyan
OBJECTIVE: A cross-sectional study was conducted (2012-2013) to evaluate the prevalence of 1) malocclusion and 2) occlusal characteristics in 13- to 18-yearold adolescents in San Juan, Puerto Rico (PR) from selected high schools in the municipality of San Juan. METHODS: The study sample consisted of 155 adolescents. The University of Puerto Rico's IRB approved the study and consent and assent were completed for or by each participant, as applicable. A calibrated dentist performed a single-visit dental evaluation at each school...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28622360/the-seroprevalence-of-west-nile-virus-in-israel-a-nationwide-cross-sectional-study
#3
Ravit Bassal, Tamy Shohat, Zalman Kaufman, Batya Mannasse, Eilat Shinar, Doron Amichay, Mira Barak, Anat Ben-Dor, Adina Bar Haim, Daniel Cohen, Ella Mendelson, Yaniv Lustig
West Nile Virus (WNV) is endemic in Israel, affecting yearly 40-160 individuals. Israel is located on a central migratory path between Africa and Eurasia and most West Nile Fever (WNF) cases reported in recent years were among residents of the coastal plain. The aim of the study was to evaluate the seroprevalence of WNV among the Israeli population and to assess correlates for WNV infection. A cross-sectional nationwide serologic survey was conducted using 3,145 serum samples collected by the national Israeli serum bank during 2011-2014, representing all age and population groups in Israel...
2017: PloS One
https://www.readbyqxmd.com/read/28605885/epidemiology-of-animal-bites-and-factors-associated-with-delays-in-initiating-post-exposure-prophylaxis-for-rabies-prevention-among-animal-bite-cases-a-population-based-study
#4
Firooz Esmaeilzadeh, Abdolhalim Rajabi, Sajad Vahedi, Mohammad Shamsadiny, Mousa Ghelichi Ghojogh, Nahid Hatam
Objectives: One way to prevent deaths due to rabies is the timely utilization of post-exposure prophylaxis (PEP). Therefore, in addition to an understanding of the epidemiological distribution of animal bites, it is necessary to explore the factors leading to delays in PEP initiation. Methods: This cross-sectional study was conducted in Iran in 2011, and included 7097 cases of animal bites recorded at the Rabies Treatment Center of the Shiraz University of Medical Sciences using the census method...
2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28598387/occlusal-features-and-caries-experience-of-hong-kong-chinese-preschool-children-a-cross-sectional-study
#5
Shinan Zhang, Edward Chin Man Lo, Chun Hung Chu
Objective: To study occlusal features and their relation to caries experience in Hong Kong Chinese preschool children. Methods: Seven kindergarten classes in Hong Kong were selected using a stratified random sampling method, and the 4- and 5-year-old Chinese kindergarten children were invited to join the survey. Two calibrated dentists performed the clinical examinations in the kindergartens. Occlusion features, including incisal overjet; canine and molar relationship; median diastema; and primate space as well as malocclusion features, including crossbite; anterior open bite; and scissor bite, were recorded...
June 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28593119/provider-patient-communication-about-zika-during-prenatal-visits
#6
Fangjian Guo, Alexander R Norton, Erika L Fuchs, Jacqueline M Hirth, Mariano A Garcia-Blanco, Abbey B Berenson
Zika virus transmission within and between the Americas is of global concern. This study assessed knowledge about the Zika virus among pregnant women in the United States, their travel plans to endemic areas, and whether their health care providers discussed Zika with them. This cross-sectional study used data from 492 pregnant women (18-50 years) from an online survey conducted from April 8 to July 27, 2016. Pregnant women were recruited online through Facebook, Twitter, Craigslist, and Reddit. Almost all (97...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28588178/assessment-of-difficulties-associated-with-endotracheal-intubation-using-modified-mallampati-and-upper-lip-bite-test
#7
D Banik, L Ray, A K Akhtaruzzaman, D K Bhowmick, M S Hossain, M S Islam, M F Haque
This study was aimed at finding the parameters for prediction of difficulty in endotracheal intubation, that are easy to examine and that could better predict difficulty. The current observational prospective, cross sectional study was conducted in the department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2015 to September 2015 comprising 180 patient of both sexes requiring endotracheal intubation were arranged into two groups, Group A: Modified Mallampati test Group and Group B: Modified Mallampati & upper lip bite test group (combined) Assessment of difficulty in intubation was done by Cormack & Lehane direct Laryngoscopic grading...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28585258/masticatory-muscle-architecture-in-a-water-rat-from-australasia-murinae-hydromys-and-its-implication-for-the-evolution-of-carnivory-in-rodents
#8
P-H Fabre, A Herrel, Y Fitriana, L Meslin, L Hautier
Murines are well known for their generalist diet, but several of them display specializations towards a carnivorous diet such as the amphibious Indo-Pacific water-rats. Despite the fact that carnivory evolved repeatedly in this group, few studies have investigated associated changes in jaw muscle anatomy and biomechanics. Here, we describe the jaw muscles and cranial anatomy of a carnivorous water-rat, Hydromys chrysogaster. The architecture of the jaw musculature of six specimens captured both on Obi and Papua were studied and described using dissections...
June 6, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28576950/retrospective-case-reports-of-two-central-north-carolina-residents-frequency-of-tick-bites-and-associated-illnesses-2001-2014
#9
Marcia E Herman-Giddens, D Marcus Herman-Giddens
BACKGROUND Tick bites are a source of illness and disease agents that may lead to morbidity and occasional fatalities in North Carolina. Public health interest in tick-borne illness and disease has increased due to continuing discoveries of tick-borne diseases and their increasing geographic spread and disease incidence. There are no data published on lay individuals with cumulative tick bites and associated illnesses over a period of years.METHODS We learned of a married couple living on a central North Carolina property who had used reasonable bite prevention methods, kept attached ticks after removal, and recorded dates and related illness records from 2001-2014...
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28576607/extensiometric-analysis-of-strain-in-craniofacial-bones-during-implant-supported-palatal-expansion
#10
Carlos Nelson Elias, Daniel Jogaib Fernandes, Denis Souza Zanivan, Yuri Resende Fonseca
Palatal expansion has several orthodontic and orthopedic applications, such as increasing maxillary transverse dimensions and correcting maxillary atresia, oral breathing, and skeletal cross-bites. Little is known about the strain to which craniofacial bones are submitted when a palatal expander is loaded. The objectives of the present work were to propose a new palatal bone-borne titanium device (expansion screw), to determine patterns of strain distribution in craniofacial bones during palatal expansion and to show the clinical results of a new palatal expander supported by implants...
May 25, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28569424/single-incision-percutaneous-pericardial-icd-lead-placement-in-a-piglet-model
#11
Bradley C Clark, Justin D Opfermann, Tanya D Davis, Axel Krieger, Charles I Berul
INTRODUCTION: Our group has demonstrated the feasibility of percutaneous pericardial ICD lead placement in a piglet model utilizing direct visualization from a lateral thoracoscopic approach. Development of a novel delivery tool that incorporates visualization allows for the procedure to be performed with a 1 cm subxiphoid incision. METHODS AND RESULTS: A 1 cm incision is made in the subxiphoid area and a novel self-anchoring delivery tool is inserted. A rigid thoracoscope and needle are inserted into two crossed working channels of the tool...
June 1, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28542227/health-beliefs-of-school-age-rural-children-in-podoconiosis-affected-families-a-qualitative-study-in-southern-ethiopia
#12
Abebayehu Tora, Getnet Tadele, Abraham Aseffa, Colleen M McBride, Gail Davey
BACKGROUND: Several studies have suggested investigation of health beliefs in children to be an important pre-condition for primary prevention of disease. However, little effort has been made to understand these in the context of podoconiosis. This study therefore aimed to explore the health beliefs of school-age rural children in podoconiosis-affected families. METHODOLOGY/PRINCIPAL FINDINGS: A cross sectional qualitative study was conducted in March 2016 in Wolaita Zone, Southern Ethiopia...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28541371/knowledge-about-the-human-immunodeficiency-syndrome-among-elders-in-a-unit-for-the-care-of-the-elderly
#13
Giovanna Gaudenci Nardelli, Bruna Stephanie Sousa Malaquias, Eliana Maria Gaudenci, Carolina Silva Ledic, Nayara Freitas Azevedo, Vitória Eugênia Martins, Álvaro da Silva Santos
Objective: To analyze the knowledge of elders regarding HIV/AIDS. Methods: Descriptive, cross-sectional, quantitative study, with 457 elders from the Unit for the Care of Elders in Uberaba - Minas Gerais, lasting 3 months. The instruments used were the Mental State Mini-exam and a questionnaire on the human immunodeficiency virus for elders, together with frequency measures for their analysis. Results: Most participants were female (74%), between 60 and 69 y/o (51%)...
May 18, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28512539/longitudinal-effects-of-rapid-maxillary-expansion-on-masticatory-muscles-activity
#14
Elena Di Palma, Michele Tepedino, Claudio Chimenti, Gianluca M Tartaglia, Chiarella Sforza
BACKGROUND: To investigate the modifications induced by rapid maxillary expansion (RME) on the electromyographic (EMG) activities of the anterior temporal and superficial masseter muscles, in patients without pre-treatment EMG alterations. MATERIAL AND METHODS: Twenty-one patients with unilateral posterior cross-bite selected from the orthodontic department of the University of L'Aquila (Italy), were enrolled. There was no control group in this study since each subject acted as a control of her/himself...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28507562/antivenomics-as-a-tool-to-improve-the-neutralizing-capacity-of-the-crotalic-antivenom-a-study-with-crotamine
#15
Ricardo Teixeira-Araújo, Patrícia Castanheira, Leonora Brazil-Más, Francisco Pontes, Moema Leitão de Araújo, Maria Lucia Machado Alves, Russolina Benedeta Zingali, Carlos Correa-Netto
BACKGROUND: Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on the guidelines defined by the regulatory agency of the Brazilian Ministry of Health, ANVISA...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28461874/epidemiological-study-of-snakebites-in-ardabil-province-iran
#16
Esmaeil Farzaneh, Nasrin Fouladi, Yousef Shafaee, Zahra Mirzamohammadi, Farnaz Naslseraji, Omid Mehrpour
INTRODUCTION: Average annual incidence of snakebite worldwide is between 5.5 to 1.2 million, and at least 125,000 of them are fatal. In Iran, around 4,500-11,000 snakebites occur annually, and a small number of them are fatal. Snake bites can cause intoxity and immediate death in patients, and the aim of this study was to investigate the epidemiological study of snakebites in Ardabil Province. METHODS: This study was a cross-sectional that has been done on 67 snakebite patients who were admitted to the Imam Khomeini Hospital of Ardabil during 2008-2013...
March 2017: Electronic Physician
https://www.readbyqxmd.com/read/28447749/dental-and-periodontal-phenotypes-of-dlx2-overexpression-in-mice
#17
Jiewen Dai, Jiawen Si, Ningjuan Ouyang, Jianfei Zhang, Dandan Wu, Xudong Wang, Guofang Shen
Distal-less homeobox 2 (Dlx2) is a member of the homeodomain family of transcription factors and is important for the development of cranial neural crest cells (CNCCs)‑derived craniofacial tissues. Previous studies revealed that Dlx2 was expressed in the cementum and a targeted null mutation disrupted tooth development in mice. However, whether Dlx2 overexpression may impair in vivo tooth morphogenesis remains to be elucidated. The present study used a transgenic mouse model to specifically overexpress Dlx2 in neural crest cells in order to identify the dental phenotypes in mice by observation, micro‑computed tomography and histological examination...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28443579/determining-the-efficiency-of-different-preoperative-difficult-intubation-tests-on-patients-undergoing-caesarean-section
#18
İlker Yıldırım, Mehmet Turan İnal, Dilek Memiş, F Nesrin Turan
BACKGROUND: Pregnancy induced anatomical and physiological changes in the airway makes airway management difficult in obstetric patients, thus the preoperative evaluation of the airway is important for obstetric patients. AIMS: The first aim was determine the effectiveness of the modified mallampati test, the interincisor, sternomental, thyromental distances, the upper limb bite tests and the second aim was to access the effectiveness of the combination of the upper limb bite test with the other tests in obstetric patients...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28438410/vaccination-with-recombinant-modified-vaccinia-ankara-mva-viruses-expressing-single-african-horse-sickness-virus-vp2-antigens-induced-cross-reactive-virus-neutralising-antibodies-vnab-in-horses-when-administered-in-combination
#19
Nicola Mary Manning, Katarzyna Bachanek-Bankowska, Peter Paul Clement Mertens, Javier Castillo-Olivares
African horse sickness is a lethal viral disease of equids transmitted by biting midges of the Genus Culicoides. The disease is endemic to sub-Saharan Africa but outbreaks of high mortality and economic impact have occurred in the past in non-endemic regions of Africa, Asia and Southern Europe. Vaccination is critical for the control of this disease but only live attenuated vaccines are currently available. However, there are bio-safety concerns over the use of this type of vaccines, especially in non-endemic countries, and live attenuated vaccines do not have DIVA (Differentiation of Infected from Vaccinated Animals) capacity...
April 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28422977/defining-the-complex-phenotype-of-severe-systemic-loxoscelism-using-a-large-electronic-health-record-cohort
#20
Jamie R Robinson, Vanessa E Kennedy, Youssef Doss, Lisa Bastarache, Joshua Denny, Jeremy L Warner
OBJECTIVE: Systemic loxoscelism is a rare illness resulting from the bite of the recluse spider and, in its most severe form, can lead to widespread hemolysis, coagulopathy, and death. We aim to describe the clinical features and outcomes of the largest known cohort of individuals with moderate to severe loxoscelism. METHODS: We performed a retrospective, cross sectional study from January 1, 1995, to December 31, 2015, at a tertiary-care academic medical center, to determine individuals with clinical records consistent with moderate to severe loxoscelism...
2017: PloS One
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