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https://www.readbyqxmd.com/read/28345344/unravelling-and-quantifying-the-nmr-invisible-metabolites-interacting-with-human-serum-albumin-by-binding-competition-and-t2-relaxation-based-decomposition-analysis
#1
Ruben Barrilero, Noelia Ramirez, Joan Carles Vallvé, Delia Taverner, Rocío Fuertes, Núria Amigó, Xavier Correig
Quantitative profiling of low-molecular-weight metabolites (LMWM) by 1H-NMR is routinely used in high-throughput serum metabolomics. First, the protein background is attenuated using a T2 filter, then the LMWM signals are resolved by line-shape fitting. However, protein binding modifies the motional properties of LMWM and their signal partially attenuates with the T2 filter, along with the protein background. Consequently, the quantified LMWM signal does not reflect the total concentration in serum but the non-binding part...
March 27, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28341310/women-in-leadership-why-so-few-and%C3%A2-what-to-do-about-it
#2
Christina M Surawicz
The numbers of women in medical school and in medical training have increased dramatically and are near 50% overall, but the number of women who advance to senior and leadership positions is not nearly this high. There are many reasons why the number of women in leadership roles in academic medicine has not kept pace with the number of women entering the field of medicine. Two popular themes are the glass ceiling (referring to an invisible barrier to advancement) and the leaky pipeline (the loss of women faculty along the path, or pipeline, to advancement)...
December 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28340912/autophagy-and-the-invisible-line-between-life-and-death
#3
REVIEW
Chrisna Swart, Andre Du Toit, Ben Loos
For a considerable time cell death has been considered to represent mutually exclusive states with cell death modalities that are governed by their inherent and unique mode of action involving specific molecular entities and have therefore been studied primarily in isolation. It is now, however, becoming increasingly clear that these modalities are regulated by similar pathways and share a number of initiator and effector molecules that control both cell death as well as cell survival mechanisms, demanding a newly aligned and integrative approach of cell death assessment...
December 2016: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28339799/no-longer-invisible-understanding-the-psychosocial-impact-of-skin-color-stratification-in-the-lives-of-african-american-women
#4
J Camille Hall
This article examines how skin color stratification, termed "colorism," affects the psychological well-being of African American women. Previous research has shown that the experience of colorism is pervasive within the black community and that black women have been culturally or personally affected by intraracial discrimination. This article describes a qualitative study that used focus groups to investigate the experiences of black women that were categorized according to their self-ascribed skin tone group...
February 27, 2017: Health & Social Work
https://www.readbyqxmd.com/read/28337425/post-prostatectomy-image-guided-radiotherapy-the-invisible-target-concept
#5
REVIEW
Florent Vilotte, Mickael Antoine, Maxime Bobin, Igor Latorzeff, Stéphane Supiot, Pierre Richaud, Laurence Thomas, Nicolas Leduc, Stephane Guérif, Jone Iriondo-Alberdi, Renaud de Crevoisier, Paul Sargos
In the era of intensity-modulated radiation therapy, image-guided radiotherapy (IGRT) appears crucial to control dose delivery and to promote dose escalation while allowing healthy tissue sparing. The place of IGRT following radical prostatectomy is poorly described in the literature. This review aims to highlight some key points on the different IGRT techniques applicable to prostatic bed radiotherapy. Furthermore, methods used to evaluate target motion and to reduce planning target volume margins will also be explored...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28333581/the-social-construction-of-fibromyalgia-as-a-health-problem-from-the-perspective-of-policies-professionals-and-patients
#6
Erica Briones-Vozmediano
BACKGROUND: Fibromyalgia is a painful chronic disease, suffered mainly by women, that consolidates a number of symptoms and skeletal muscle issues which are little understood. OBJECTIVES: To explore the social construction of FM from the perspective of health policies, patients, and health professionals involved in their medical attention. METHODS: I) Policy review of national and regional health plans in a national and international context, the clinical protocols for fibromyalgia in Spain, and the Parliamentary initials in the European and Spanish context; and ii) Qualitative study involving 28 personal interviews with 16 fibromyalgia patients and 12 interviews with health care professionals in Spain...
2017: Global Health Action
https://www.readbyqxmd.com/read/28326821/understanding-self-harm-in-older-people-a-systematic-review-of-qualitative-studies
#7
Anne Pamela Frances Wand, Carmelle Peisah, Brian Draper, Henry Brodaty
OBJECTIVE: Rates of suicide in older adults are generally higher than other age groups. Although risk factors for suicide attempts, and self-harm more generally, in this population are well-characterised, many of these vulnerabilities are common to older people and individual motivations are less well understood. Qualitative research may reveal more about the underlying thought processes, meaning and experiences of older people who self-harm. METHODS: A systematic review of qualitative studies examining the reasons why older people have self-harmed was undertaken by searching databases and screening the reference lists of articles...
March 22, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28318432/my-femme-friendship
#8
Rachel E Silverman
This autoethnographic study of femme friendship explores the connection and relationship between two femme lesbians-my femme friend Amber and myself. The shared experience of invisibility and the related perils and privileges that come with passing as straight enact a bond unlike any either of us have previously experienced. Meeting within the context of a polyamorous relationship adds a layer of complexity to our friendship that deepens the relationship. The story of our friendship showcases a specific sort of friendship, one grounded in theories of gender performance, sexuality, invisibility, and language...
March 20, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28302650/erratum-2016-presidential-address-diabetes-at-212%C3%A2-confronting-the-invisible-disease-diabetes-care-2016-39-1657-1663
#9
Desmond Schatz
No abstract text is available yet for this article.
March 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28302127/erratum-to-treating-the-invisible-gaps-and-opportunities-for-enhanced-tb-control-along-the-thailand-myanmar-border
#10
Naomi Tschirhart, Sein Sein Thi, Lei Lei Swe, Francois Nosten, Angel M Foster
No abstract text is available yet for this article.
March 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28299253/lugol-s-iodine-identifies-dysplastic-tissue-in-precancerous-lesions-a-clinical-trial
#11
Shereen Fatima, Rajarshi Basu, Neelakamal H Hallur
INTRODUCTION: Intraepithelial dysplasia, or "invisible" precancerous lesions, provides a challenge for visualization to the surgical team. The prognostic relevance of dysplasia and carcinoma in situ at surgical margins is well documented. MATERIALS AND METHODS: We evaluated the use of Lugol's iodine in visualizing the surgical margins of dysplastic tissue by an observational study of 100 patients having oral precancerous lesions between June 2013 and March 2016...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28298406/obstructive-sleep-apnoea-in-acute-coronary-syndrome-the-invisible-threat
#12
EDITORIAL
Michael Arzt, Andrea Hetzenecker, Patrick Lévy
No abstract text is available yet for this article.
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28297598/centimeter-scale-cvd-growth-of-highly-crystalline-single-layer-mos2-film-with-spatial-homogeneity-and-the-visualization-of-grain-boundaries
#13
Li Tao, Kun Chen, Zefeng Chen, Wenjun Chen, Xuchun Gui, Huanjun Chen, Xinming Li, Jian-Bin Xu
MoS2 monolayer attracts considerable attention due to its semiconducting nature with a direct bandgap which can be tuned by various approaches. Yet a controllable and low-cost method to produce large-scale, high-quality, and uniform MoS2 monolayer continuous film, which is of crucial importance for practical applications and optical measurements, remains a great challenge. Most previously reported MoS2 monolayer films had limited crystalline sizes, and the high density of grain boundaries inside the films greatly affected the electrical properties...
March 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28297280/an-innovative-method-to-acquire-the-location-of-point-a-for-cervical-cancer-treatment-by-hdr-brachytherapy
#14
Liyun Chang, Sheng-Yow Ho, Shyh-An Yeh, Tsair-Fwu Lee, Pang-Yu Chen
Brachytherapy of local cervical cancer is generally accomplished through film-based treatment planning with the prescription directed to point A, which is invisible on images and is located at a high-dose gradient area. Through a standard reconstruction method by digitizing film points, the location error for point A would be 3 mm with a condition of 30° curvature tandem, which is 10° away from the gantry rotation axis of a simulator, and has an 8.7 cm interval between the flange and the isocenter. To reduce the location error of the reconstructed point A, this paper proposes a method and demonstrates its accuracy...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295298/invisible-friends-across-four-countries-kenya-malawi-nepal-and-the-dominican-republic
#15
J Bradley Wigger
Cross-cultural comparisons of the prevalence of invisible/imaginary companions are difficult due to the use of various methods of data gathering and the lack of sampling in developing countries. The present study took place among 443 children (3-8-year-olds) in four different countries (Kenya, Malawi, Nepal and the Dominican Republic) employing the same interview method. Among all the children 21% affirmed that they had invisible/imaginary companions at the time of the interview. But the rates between countries varied significantly from a low of 5% in Nepal to a high of 34% in the Dominican Republic...
March 14, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28295021/coherent-selection-of-invisible-high-order-electromagnetic-excitations
#16
Ming Lun Tseng, Xu Fang, Vassili Savinov, Pin Chieh Wu, Jun-Yu Ou, Nikolay I Zheludev, Din Ping Tsai
Far-field spectroscopy and mapping of electromagnetic near-field distribution are the two dominant tools for analysis and characterization of the electromagnetic response in nanophotonics. Despite the widespread use, these methods can fail at identifying weak electromagnetic excitations masked by stronger neighboring excitations. This is particularly problematic in ultrafast nanophotonics, including optical sensing, nonlinear optics and nanolasers, where the broad resonant modes can overlap to a significant degree...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28294461/the-construction-of-help-during-radiotherapy-re-defining-informal-care
#17
Lynda Appleton, Elizabeth Perkins
OBJECTIVES: This paper will explore how help is constructed during and following radiotherapy for patients with cancer. METHODS: Grounded theory methods were used in the study to explore the way in which family members and friends constructed a role for themselves in relation to patients receiving radiotherapy. A total of 22 helpers were interviewed. Patients were being treated for a range of cancers including breast, prostate, colorectal and head and neck. RESULTS: Respondents in this study consistently defined themselves as 'helpers' rather than 'carers'...
March 11, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28293132/stokes-phenomena-in-discrete-painlev%C3%A3-ii
#18
N Joshi, C J Lustri, S Luu
We consider the asymptotic behaviour of the second discrete Painlevé equation in the limit as the independent variable becomes large. Using asymptotic power series, we find solutions that are asymptotically pole-free within some region of the complex plane. These asymptotic solutions exhibit Stokes phenomena, which is typically invisible to classical power series methods. We subsequently apply exponential asymptotic techniques to investigate such phenomena, and obtain mathematical descriptions of the rapid switching behaviour associated with Stokes curves...
February 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28290671/mobility-and-core-protein-binding-patterns-of-disordered-c-terminal-tails-in-%C3%AE-tubulin-isotypes
#19
Yoann Laurin, Joel Eyer, Charles H Robert, Chantal Prevost, Sophie Sacquin-Mora
Although they play a significant part in the regulation of microtubule structure, dynamics, and function, the disordered C-terminal tails of tubulin remain invisible to experimental structural methods and do not appear in the crystallographic structures that are currently available in the Protein Data Bank. Interestingly, these tails concentrate most of the sequence variability between tubulin isotypes and are the sites of the principal post-translational modifications undergone by this protein. Using homology modeling, we developed two complete models for the human αI/βI- and αI/βIII-tubulin isotypes that include their C-terminal tails...
March 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28289480/ultrasound-elastography-for-determination-of-the-age-of-venous-thrombi-evaluation-of-thrombus-evolution-in-patients-after-sclerotherapy
#20
Łukasz Paluch, Ewa Nawrocka-Laskus, Agnieszka Dąbrowska, Tadeusz Popiela, Jerzy Walecki
BACKGROUND: Venous thrombosis is a multicausal disease involving intravenous clot formation. It may occur spontaneously or after provoking events, such as traumatic injuries to the pelvis, upper and lower extermities, immobilization, intravascular procedures, including venous catheterization or injection. Color Doppler ultrasonography is a rapid and non-invasive technique for evaluation of venous disease. It is a very sensitive method for detection of thrombi, but has some limitations, e...
2017: Polish Journal of Radiology
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