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https://www.readbyqxmd.com/read/28537958/everyday-life-after-colon-cancer-the-visible-and-invisible-challenges
#1
Susanne Stuhlfauth, Line Melby, Ragnhild Hellesø
BACKGROUND: There is little research regarding how everyday life is affected by colon cancer treatment. Few studies exist that exclusively examine patients with Dukes C colon cancer. Most studies include other types of bowel cancer and different stages. OBJECTIVES: The aims of this study were to explore and describe how colon cancer survivors experience everyday life in general and sexuality in particular after treatment of Dukes C colon cancer. METHODS: The study is exploratory and descriptive and uses semistructured interviews to collect data...
May 23, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28537842/-invisible-during-my-own-crisis-responses-of-lgbt-people-of-color-to-the-orlando-shooting
#2
Johanna L Ramirez, Kirsten A Gonzalez, M Paz Galupo
On June 12th, 2016, the Pulse nightclub in Orlando, Florida was the target of one of the country's deadliest mass shootings. Pulse, a gay nightclub, was hosting a Latin Pride Night the evening of the tragedy, resulting in the death of 49 victims and 53 casualties, over 90% of whom were lesbian, gay, bisexual, and transgender (LGBT) Latinx people, specifically. The present research investigates the narrative responses from LGBT people of color (LGBT-POC) following the tragedy. Results included an analysis of 94 participant narrative responses...
May 24, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28534504/crystal-structure-of-the-receptor-binding-domain-of-the-spike-glycoprotein-of-human-betacoronavirus-hku1
#3
Xiuyuan Ou, Hongxin Guan, Bo Qin, Zhixia Mu, Justyna A Wojdyla, Meitian Wang, Samuel R Dominguez, Zhaohui Qian, Sheng Cui
Human coronavirus (CoV) HKU1 is a pathogen causing acute respiratory illnesses and so far little is known about its biology. HKU1 virus uses its S1 subunit C-terminal domain (CTD) and not the N-terminal domain like other lineage A β-CoVs to bind to its yet unknown human receptor. Here we present the crystal structure of HKU1 CTD at 1.9 Å resolution. The structure consists of three subdomains: core, insertion and subdomain-1 (SD-1). While the structure of the core and SD-1 subdomains of HKU1 are highly similar to those of other β-CoVs, the insertion subdomain adopts a novel fold, which is largely invisible in the cryo-EM structure of the HKU1 S trimer...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28528909/melanopsin-contributions-to-the-representation-of-images-in-the-early-visual-system
#4
Annette E Allen, Riccardo Storchi, Franck P Martial, Robert A Bedford, Robert J Lucas
Melanopsin photoreception enhances retinal responses to variations in ambient light (irradiance) and drives non-image-forming visual reflexes such as circadian entrainment [1-6]. Melanopsin signals also reach brain regions responsible for form vision [7-9], but melanopsin's contribution, if any, to encoding visual images remains unclear. We addressed this deficit using principles of receptor silent substitution to present images in which visibility for melanopsin versus rods+cones was independently modulated, and we recorded evoked responses in the mouse dorsal lateral geniculate nucleus (dLGN; thalamic relay for cortical vision)...
May 17, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28522846/effect-of-compressibility-and-non-uniformity-in-flow-on-the-scattering-pattern-of-acoustic-cloak
#5
Hyeonbin Ryoo, Wonju Jeon
During the last decade, most of acoustic cloak research has been done within a theoretical framework in which the medium is at rest. However, such an acoustic cloak cannot preserve its unique properties or functions to make an object acoustically invisible in the presence of flow. In this study, we propose a theoretical framework to accurately investigate the effect of compressibility and non-uniformity in flow on the scattering pattern of acoustic cloak. In the formulation, the wave operator is coupled with the non-uniform velocity vector, and the equivalent source terms due to mean flow are divided into the compressibility effect and the non-uniformity effect with their own physical meanings...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28520971/mass-spectrometry-for-serine-adp-ribosylation-think-o-glycosylation
#6
Juan J Bonfiglio, Thomas Colby, Ivan Matic
Protein ADP-ribosylation (ADPr), a biologically and clinically important post-translational modification, exerts its functions by targeting a variety of different amino acids. Its repertoire recently expanded to include serine ADPr, which is emerging as an important and widespread signal in the DNA damage response. Chemically, serine ADPr (and more generally o-glycosidic ADPr) is a form of o-glycosylation, and its extreme lability renders it practically invisible to standard mass spectrometry approaches, often leading to erroneous localizations...
May 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28516212/anatomical-visualization-of-neural-course-and-distribution-of-anterior-ascending-aortic-plexus
#7
Tomokazu Kawashima, Fumi Sato
The aim of this study was to document the detailed anatomy of neural course and distribution on the anterior ascending aorta, to identify the high and low density areas of the anterior ascending aortic plexus for further understandings in cardiovascular surgery. The embalmed hearts of 42 elderly individuals were submacroscopically and microscopically examined, after excluding any that were macroscopically abnormal. With its origins in the anterior ascending aortic plexus, the right coronary plexus substantially innervated the right coronary artery, the right atrium and ventricle, and the sinus node...
May 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28514188/the-invisibility-of-mild-traumatic-brain-injury-impaired-cognitive-performance-as-a-silent-symptom
#8
Leore R Heim, Miaad Badar, Shahaf Edut, Lital Rachmany, Renana Baratz, Ran Lin, Aviya Elpaz, Doaa Qubty, Lior Bikovski, Vardit Rubovitch, Shaul Schreiber, Chaim G Pick
The present study was designed to tackle two notorious features of mild Traumatic Brain Injury (mTBI) - heterogeneity and invisibility - by characterizing the full scope of mTBI symptoms. Mice were exposed to brain injuries of different intensities utilizing a weight-drop model (10, 30, 50, and 70g), and subsequently subjected to a comprehensive battery of behavioral tests at different time points, and immunohistochemical examination of cortical slices. While the physiological, neurological, emotional, and motor function of mTBI mice, i...
May 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28511561/depression-of-the-maxillary-sinus-anterior-wall-and-its-influence-on-panoramic-radiography-appearance
#9
Kazuhito Yoshida, Motoki Fukuda, Kenichi Gotoh, Eiichiro Ariji
OBJECTIVES: To clarify the depression aspect of the maxillary sinus anterior wall, and to investigate its relationship with the panoramic image appearance of a diagonal line from the inferior part of the so-called panoramic innominate line to the medial portion of the orbital floor line. METHODS: Based on computed tomographic (CT) data, panoramic images were simulated for two typical cases with and without anterior wall depression. Next, on axial CT images of 1689 subjects (3378 sinuses) stored in our image database, the wall depths were measured and analyzed for their relationships with the panoramic appearances of the diagonal line, classified into invisible, obscure, and clear patterns...
May 16, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28508701/beyond-invisibility-queer-intelligibility-and-symbolic-annihilation-in-healthcare
#10
Alex Müller
Sexual minority health is increasingly receiving attention by health sciences education and healthcare, with the core argument being that health can be improved by challenging sexual minority invisibility. Invisibility as a concept, however, does not allow for a deeper theoretical engagement with the reasons and consequences of the lack of representation of queerness in healthcare. Drawing on empirical research with queer healthcare users in South Africa, I argue that 'invisibility' actually encompasses two distinct, though related, concepts: queer symbolic annihilation as the reason for the exclusion of queer identities in health professions education and, by consequence, in healthcare; and queer (un)intelligibility as the consequence of this systemic erasure...
May 16, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28505675/-anti-lymph-angiogenic-strategies-to-improve-corneal-graft-survival
#11
Felix Bock, Claus Cursiefen
Corneal transplantation (keratoplasty) is the most frequently performed form of transplantation worldwide. A rejection reaction against the transplant is the main complication occurring after transplantation in an already vascularized, so-called "high-risk" recipient eye. Our group has shown that clinically invisible lymphatic vessels play a crucial role in the induction of a rejection reaction against the corneal graft, and that anti-(lymph)angiogenic therapies in the mouse model of keratoplasty can significantly improve transplant survival...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28504733/uncloaking-diffusive-light-invisibility-cloaks-by-speckle-analysis
#12
Andreas Niemeyer, Frederik Mayer, Andreas Naber, Milan Koirala, Alexey Yamilov, Martin Wegener
Within the range of validity of the stationary diffusion equation, an ideal diffusive-light invisibility cloak can make an arbitrary macroscopic object hidden inside of the cloak indistinguishable from the surroundings for all colors, polarizations, and directions of incident visible light. However, the diffusion equation for light is an approximation which becomes exact only in the limit of small coherence length. Thus, one expects that the cloak can be revealed by illumination with coherent light. The experiments presented here show that the cloaks are robust in the limit of large coherence length but can be revealed by analysis of the speckle patterns under illumination with partially coherent light...
May 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28503031/re-interpreting-narratives-of-childhood-language-brokering-over-time
#13
Marjorie Faulstich Orellana, Ann Phoenix
This article probes how childhood experiences are actively taken into adult lives and thus challenges the unwitting and unintentional reproduction of an adult-child binary in childhood studies. We do this by analyzing interviews with one adult daughter of immigrants from Mexico to the United States at four points in time (ages 19, 26, 27, and 33). Using narrative analysis to examine the mutability of memory, we consider how Eva oriented herself to her childhood story, what was salient and invisible in each recount, the values she associated with the practice, and the meanings she took from her experiences...
May 2017: Childhood
https://www.readbyqxmd.com/read/28502218/recommendations-to-reduce-inequalities-for-lgbt-people-facing-advanced-illness-accesscare-national-qualitative-interview-study
#14
Katherine Bristowe, Matthew Hodson, Bee Wee, Kathryn Almack, Katherine Johnson, Barbara A Daveson, Jonathan Koffman, Linda McEnhill, Richard Harding
BACKGROUND: Lesbian, gay, bisexual and/or trans (LGBT) people have higher risk of certain life-limiting illnesses and unmet needs in advanced illness and bereavement. ACCESSCare is the first national study to examine in depth the experiences of LGBT people facing advanced illness. AIM: To explore health-care experiences of LGBT people facing advanced illness to elicit views regarding sharing identity (sexual orientation/gender history), accessing services, discrimination/exclusion and best-practice examples...
April 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28501996/application-of-hydrogel-nanoparticles-for-the-capture-concentration-and-preservation-of-low-abundance-biomarkers
#15
Ruben Magni, Alessandra Luchini
In the recent years, a lot of emphasis has been placed on the discovery and detection of clinically relevant biomarkers. Biomarkers are crucial for the early detection of several diseases, and they play an important role in the improvement of current treatments, thus reducing patient mortality rate. Because biofluids account to 60% of the body mass, they represent a goldmine of significant biomarkers. Unfortunately, because of their low concentration in body fluids, their lability, and the presence of high abundance proteins (i...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28498685/pt-symmetric-scattering-in-flow-duct-acoustics
#16
Yves Aurégan, Vincent Pagneux
We show theoretically and experimentally that the propagation of an acoustic wave in an airflow duct going through a pair of diaphragms, with equivalent amounts of mean-flow-induced effective gain and loss, displays all the features of a parity-time (PT) symmetric system. Using a scattering matrix formalism, we observe, experimentally, the properties which reflect the PT symmetry of the scattering acoustical system: the existence of spontaneous symmetry breaking with symmetry-broken pairs of scattering eigenstates showing amplification and reduction, and the existence of points with unidirectional invisibility...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28497244/invisible-voices-an-intersectional-exploration-of-quality-of-life-for-elderly-south-asian-immigrant-women-in-a-canadian-sample
#17
Shahid Alvi, Arshia U Zaidi
Despite the emerging presence of South Asian elderly population in Canada, there continues to be a paucity of research concerning the immigration and acculturation experiences of these marginalized elderly populations and their quality of life. This research builds knowledge of the quality of life experiences faced by South Asian elderly immigrant women residing in Canada using an intersectional analytical framework. While there is a gradually developing body of research regarding elder persons globally, the present research is unique in that explores challenges, stresses and strains, and builds an understanding of the treatment of older ethnic minorities and immigrant families...
May 11, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/28490818/the-structural-invisibility-of-outsiders-the-role-of-migrant-labour-in-the-meat-processing-industry
#18
John Lever, Paul Milbourne
This article examines the role of migrant workers in meat-processing factories in the UK. Drawing on materials from mixed methods research in a number of case study towns across Wales, we explore the structural and spatial processes that position migrant workers as outsiders. While state policy and immigration controls are often presented as a way of protecting migrant workers from work-based exploitation and ensuring jobs for British workers, our research highlights that the situation 'on the ground' is more complex...
April 2017: Sociology
https://www.readbyqxmd.com/read/28488844/mri-in-prostate-cancer-detection-and-management-a-systematic-review
#19
Fabio Monni, Paolo Fontanella, Angelica Grasso, Peter Wiklund, Yen-Chuan Ou, Marco Randazzo, Bernardo Rocco, Emanuele Montanari, Giampaolo Bianchi
INTRODUCTION: The aim of our work was to evaluate the role of multi-parametric MRI (mpMRI) in detection and management of prostate cancer (PC); specifically investigating the efficacy of mpMRI-based biopsy techniques in terms of diagnostic yield of significant prostate neoplasm and the improved management of patient who choose conservative treatments or active surveillance. EVIDENCE ACQUISITION: A systematic and critical analysis through Medline, Embase, Scopus and Web of Science databases was carried out in March 2016, following the PRISMA ("Preferred Reporting Items for Systematic Reviews and Meta-Analyses") statement...
May 8, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28485292/assessment-and-management-of-retraction-pockets
#20
Alper Cuneyt, Ewa Olszewska
This manuscript intends to review types, pathogenesis, associated risk factors, and potential methods of prevention and treatment of the retraction pockets in adults and children. The importance of retraction pockets (RP) lies in loss of original histological and anatomical structure which is associated with development of ossicular chain erosion, cho¬lesteatoma formation and potentially life threatening complications of cholesteatoma. The trans-mucosal exchange each gas in the middle ear (ME) is towards equalizing its partial pressures with the partial pressure in the environ¬ment...
February 28, 2017: Otolaryngologia Polska
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