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https://www.readbyqxmd.com/read/29760857/retrospective-chart-review-of-synthetic-cannabinoid-intoxication-with-toxicologic-analysis
#1
Payal Sud, Miles Gordon, Laura Tortora, Matthew Stripp, Damon Borg, Adam Berman
Introduction: Use of synthetic cannabinoids (SC) has recently emerged as a new drug epidemic. Our emergency departments (EDs) received a surge of SC users presenting with lethargy and bradycardia, contrasting prior reports of SC-induced tachycardia and agitation. Our goal was to describe these novel presentations and characterize the compounds. Methods: We present a case series of patients with SC intoxication who presented to our toxicology service covering two tertiary care EDs between 2/11/2015 and 6/23/2015...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29750236/method-for-evaluation-of-transverse-dimension-in-self-ligating-orthodontic-treatment-a-comparative-study
#2
Alejandra Folco, Sandra Benítez-Rogé, Diana Calabrese, Marina Iglesias, María Lumi, Pedro Hetch, María E Mateu
Knowledge of the best way to evaluate changes in transverse dimension produced by orthodontic treatment enables the estimation of potential space that may be generated and optimizes planning. The aim of this study was to compare two methods for measuring changes in transverse dimension following tooth alignment by passive self-ligating system: Method 1 (M1) considering palatal landmarks and Method 2 (M2) considering dental landmarks. Subjects were 12 patients of both sexes, aged 15 to 24 years old, with moderate crowding (Nance discrepancy -4 to -6 mm), who were treated with the Damon System at the Department of Orthodontics of the School of Dentistry, Buenos Aires University...
December 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/29749591/interplay-between-metalloproteinases-and-cell-signalling-in-blood-brain-barrier-integrity
#3
REVIEW
Irene Pla-Navarro, Damon Bevan, Mohammad K Hajihosseini, Martin Lee, Jelena Gavrilovic
The Blood-Brain Barrier (BBB) is a highly specialised interface separating the Central Nervous System (CNS) from circulating blood. Dysregulation of the BBB is a key early event in pathological conditions such as inflammation, in which the entry of activated leukocytes into the CNS is facilitated by BBB breakdown. The metzincin family of metalloproteinases (MPs) is one of the major contributors to BBB permeability as they cleave endothelial cell-cell contacts and underlying basal lamina components. However, the mechanisms by which MPs regulate BBB integrity has not yet been fully elucidated...
May 11, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29735855/mandibular-dental-arch-changes-with-active-self-ligating-brackets-combined-with-different-archwires
#4
E Atik, B Akarsu-Guven, I Kocadereli
Objective: The aim was to compare mandibular arch and incisor inclinational changes by comparing active self-ligating brackets used with different forms of archwires with a control group in nonextraction cases. Materials and Methods: The sample of 50 patients with Class I malocclusion was divided into three groups: Group I was treated with active self-ligating brackets (Nexus, Ormco/Orange, CA, USA) used with Damon arch form copper nickel-titanium (Cu-NiTi) and stainless steel (SS) wires; Group II was treated with interactive self-ligating bracket system (Empower, American Orthodontics, Sheboygan, Wis, USA) used with standard Cu-NiTi and SS wires; and Group III was treated with Roth prescribed conventional brackets (Forestadent, Pforzheim, Germany) with standard Cu-NiTi and SS wires which was designed as a control group...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29725960/towards-portable-large-scale-image-processing-with-high-performance-computing
#5
REVIEW
Yuankai Huo, Justin Blaber, Stephen M Damon, Brian D Boyd, Shunxing Bao, Prasanna Parvathaneni, Camilo Bermudez Noguera, Shikha Chaganti, Vishwesh Nath, Jasmine M Greer, Ilwoo Lyu, William R French, Allen T Newton, Baxter P Rogers, Bennett A Landman
High-throughput, large-scale medical image computing demands tight integration of high-performance computing (HPC) infrastructure for data storage, job distribution, and image processing. The Vanderbilt University Institute for Imaging Science (VUIIS) Center for Computational Imaging (CCI) has constructed a large-scale image storage and processing infrastructure that is composed of (1) a large-scale image database using the eXtensible Neuroimaging Archive Toolkit (XNAT), (2) a content-aware job scheduling platform using the Distributed Automation for XNAT pipeline automation tool (DAX), and (3) a wide variety of encapsulated image processing pipelines called "spiders...
May 3, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29720053/prevalence-risk-factors-and-clinical-consequences-of-recurrent-activation-of-a-rapid-response-team-a-multicenter-observational-study
#6
Shannon M Fernando, Peter M Reardon, Damon C Scales, Kyle Murphy, Peter Tanuseputro, Daren K Heyland, Kwadwo Kyeremanteng
INTRODUCTION: Rapid response teams (RRTs) are groups of health-care providers, implemented by hospitals to respond to distressed hospitalized patients on the hospital wards. Patients assessed by the RRT for deterioration may be admitted to the intensive care unit (ICU) or may be triaged to remain on the wards, putting them at risk of recurrent deterioration and repeat RRT activation. Previous studies evaluating outcomes of patients with recurrent deterioration and multiple RRT activations have produced conflicting results...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29691555/-clinical-research-for-non-extraction-treatment-of-maxillary-mild-to-moderate-crowding-with-damon-technology
#7
Wei Zhang, Chuan-Jie Yan, Li Li
PURPOSE: To compare the clinical efficacy of non-extraction treatment in maxillary mild-to-moderate crowding cases with Damon self-ligating system and Roth traditional brackets. METHODS: Sixty skeletalⅠorthodontic patients were selected in this study. They were divided into DamonⅠ, RothⅠ, DamonⅡ and RothⅡ group according to the bracket species and maxillary crowding degrees. Lateral cephalometric radiographs and models were measured before and after aligning and leveling to analyze the changes in dental arch and soft and hard tissue using SPSS 19...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29651519/root-resorption-due-to-orthodontic-treatment-using-self-ligating-and-conventional-brackets-a-cone-beam-computed-tomography-study
#8
Isil Aras, Idil Unal, Gencer Huniler, Aynur Aras
OBJECTIVES: Purpose of the present study was to compare external root resorption (ERR) volumetrically in maxillary incisors induced by orthodontic treatment using self-ligating brackets (Damon Q, DQ) or conventional brackets (Titanium Orthos, TO) with the help of cone-beam computed tomography (CBCT). PATIENTS AND METHODS: A sample of 32 subjects, with Angle Class I malocclusion and anterior crowding of 4-10 mm, was divided randomly into two groups: a DQ group, in which self-ligating DQ brackets with Damon archwires were used; and a TO group, in which conventional TO brackets with large Orthos archwires were applied...
April 12, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/29649876/biomolecular-simulations-under-realistic-macroscopic-salt-conditions
#9
Gregory A Ross, Ariën S Rustenburg, Patrick B Grinaway, Josh Fass, John Damon Chodera
Biomolecular simulations are typically performed in an aqueous environment where the number of ions remains fixed for the duration of the simulation, generally with either a minimally neutralizing ion environment or a number of salt pairs intended to match the macroscopic salt concentration. In contrast, real biomolecules experience local ion environments where the salt concentration is dynamic and may differ from bulk. The degree of salt concentration variability and average deviation from the macroscopic concentration remains, as yet, unknown...
April 13, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29546390/comparison-of-the-efficacy-of-tooth-alignment-among-lingual-and-labial-brackets-an-in-vitro-study
#10
Ahmad Alobeid, Tarek El-Bialy, Susanne Reimann, Ludger Keilig, Dirk Cornelius, Andreas Jäger, Christoph Bourauel
Background/objective: The aim of this study was to evaluate the efficacy of tooth alignment with conventional and self-ligating labial and lingual orthodontic bracket systems. Materials/methods: We tested labial brackets (0.022″ slot size) and lingual brackets (0.018″ slot size). The labial brackets were: (i) regular twin brackets (GAC-Twin [Dentsply]), (ii) passive self-ligating brackets including (Damon-Q® [ORMCO]; Ortho classic H4™ [Orthoclassic]; FLI®SL [RMO]), and (iii) active self-ligating brackets (GAC In-Ovation®C [DENTSPLY] and SPEED™[Strite])...
March 13, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29541765/association-between-real-time-electronic-injury-surveillance-applications-and-clinical-documentation-and-data-acquisition-in-a-south-african-trauma-center
#11
Eiman Zargaran, Richard Spence, Lauren Adolph, Andrew Nicol, Nadine Schuurman, Pradeep Navsaria, Damon Ramsey, S Morad Hameed
Importance: Collection and analysis of up-to-date and accurate injury surveillance data are a key step in the maturation of trauma systems. Trauma registries have proven to be difficult to establish in low- and middle-income countries owing to the burden of trauma volume, cost, and complexity. Objective: To determine whether an electronic trauma health record (eTHR) used by physicians can serve as simultaneous clinical documentation and data acquisition tools. Design, Setting, and Participants: This 2-part quality improvement study included (1) preimplementation and postimplementation eTHR study with assessments of satisfaction by 41 trauma physicians, time to completion, and quality of data collected comparing paper and electronic charting; and (2) prospective ecologic study describing the burden of trauma seen at a Level I trauma center, using real-time data collected by the eTHR on consecutive patients during a 12-month study period...
March 14, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29535061/4-step-protocol-for-disparities-in-stemi-care-and-outcomes-in-women
#12
Chetan P Huded, Michael Johnson, Kathleen Kravitz, Venu Menon, Mouin Abdallah, Travis C Gullett, Scott Hantz, Stephen G Ellis, Seth R Podolsky, Stephen W Meldon, Damon M Kralovic, Deborah Brosovich, Elizabeth Smith, Samir R Kapadia, Umesh N Khot
BACKGROUND: Women with ST-segment elevation myocardial infarction (STEMI) receive suboptimal care and have worse outcomes than men. Whether strategies to reduce STEMI care variability impact disparities in the care and outcomes of women with STEMI is unknown. OBJECTIVES: The study assessed the care and outcomes of men versus women with STEMI before and after implementation of a comprehensive STEMI protocol. METHODS: On July 15, 2014, the authors implemented: 1) emergency department catheterization lab activation; 2) STEMI Safe Handoff Checklist; 3) immediate transfer to an immediately available catheterization lab; and 4) radial first approach to percutaneous coronary intervention (PCI)...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29534744/impact-of-nighttime-rapid-response-team-activation-on-outcomes-of-hospitalized-patients-with-acute-deterioration
#13
Shannon M Fernando, Peter M Reardon, Sean M Bagshaw, Damon C Scales, Kyle Murphy, Jennifer Shen, Peter Tanuseputro, Daren K Heyland, Kwadwo Kyeremanteng
BACKGROUND: Rapid Response Teams (RRTs) are groups of healthcare providers that are used by many hospitals to respond to acutely deteriorating patients admitted to the wards. We sought to identify outcomes of patients assessed by RRTs outside standard working hours. METHODS: We used a prospectively collected registry from two hospitals within a single tertiary care-level hospital system between May 1, 2012, and May 31, 2016. Patient information, outcomes, and RRT activation information were stored in the hospital data warehouse...
March 14, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29521807/the-contemporary-timing-of-trauma-deaths
#14
James M Bardes, Kenji Inaba, Morgan Schellenberg, Daniel Grabo, Aaron Strumwasser, Kazuhide Matsushima, Damon Clark, Niquelle Brown, Demetrios Demetriades
BACKGROUND: The distribution of trauma deaths was classically described as trimodal. With advances in both technology and trauma systems, this was re-evaluated and found to be bimodal in the early 2000s. Over the last decade there have been continued improvements in trauma and ICU care, related to damage control techniques and evidence based ICU pathways. A better understanding of the distribution of trauma deaths may be used to improve trauma systems. This study aimed to evaluate the contemporary distribution of trauma deaths after the widespread implementation of modern trauma and critical care principles...
March 8, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29486559/binding-modes-of-ligands-using-enhanced-sampling-blues-rapid-decorrelation-of-ligand-binding-modes-via-nonequilibrium-candidate-monte-carlo
#15
Samuel C Gill, Nathan M Lim, Patrick B Grinaway, Ariën S Rustenburg, Josh Fass, Gregory A Ross, John D Chodera, David L Mobley
Accurately predicting protein-ligand binding affinities and binding modes is a major goal in computational chemistry, but even the prediction of ligand binding modes in proteins poses major challenges. Here, we focus on solving the binding mode prediction problem for rigid fragments. That is, we focus on computing the dominant placement, conformation, and orientations of a relatively rigid, fragment-like ligand in a receptor, and the populations of the multiple binding modes which may be relevant. This problem is important in its own right, but is even more timely given the recent success of alchemical free energy calculations...
March 12, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29480715/scalable-nanostructured-carbon-electrode-arrays-for-enhanced-dopamine-detection
#16
Silvia Demuru, Luca Nela, Nathan Marchack, Steven J Holmes, Damon B Farmer, George S Tulevski, Qinghuang Lin, Hariklia Deligianni
Dopamine is a neurotransmitter that modulates arousal and motivation in humans and animals. It plays a central role in the brain "reward" system. Its dysregulation is involved in several debilitating disorders such as addiction, depression, Parkinson's disease, and schizophrenia. Dopamine neurotransmission and its reuptake in extracellular space takes place with millisecond temporal and nanometer spatial resolution. Novel nanoscale electrodes are needed with superior sensitivity and improved spatial resolution to gain an improved understanding of dopamine dysregulation...
April 27, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29368157/fluorescence-correlation-spectroscopy-with-photobleaching-correction-in-slowly-diffusing-systems
#17
Cameron Hodges, Rudra P Kafle, J Damon Hoff, Jens-Christian Meiners
Fluorescence correlation spectroscopy (FCS) is a powerful tool to quantitatively study the diffusion of fluorescently labeled molecules. It allows in principle important questions of macromolecular transport and supramolecular aggregation in living cells to be addressed. However, the crowded environment inside the cells slows diffusion and limits the reservoir of labeled molecules, causing artifacts that arise especially from photobleaching and limit the utility of FCS in these applications. We present a method to compute the time correlation function from weighted photon arrival times, which compensates computationally during the data analysis for the effect of photobleaching...
January 24, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29295825/a-pivotal-phase-iii-randomised-placebo-controlled-study-of-belimumab-in-patients-with-systemic-lupus-erythematosus-located-in-china-japan-and-south-korea
#18
Fengchun Zhang, Sang-Cheol Bae, Damon Bass, Myron Chu, Sally Egginton, David Gordon, David A Roth, Jie Zheng, Yoshiya Tanaka
BACKGROUND: Intravenous belimumab plus standard of care (SoC) is approved in the USA and Europe for treatment of active, autoantibody-positive systemic lupus erythematosus (SLE). METHODS: This phase III, multicentre, randomised, double-blind, placebo-controlled study (BEL113750; NCT01345253) was conducted in 49 centres across China, Japan and South Korea (May 2011 - September 2015). Patients with SLE were randomised 2:1 to intravenous belimumab 10 mg/kg or placebo, plus SoC, every 4 weeks until Week 48...
March 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29224209/sircle-a-randomised-controlled-cost-comparison-of-self-administered-short-course-isoniazid-and-rifapentine-for-cost-effective-latent-tuberculosis-eradication
#19
Justin T Denholm, Emma S McBryde, Damon Eisen, Alan Street, Elizabeth Matchett, Caroline Chen, Thomas Shultz, Beverly Biggs, Karin Leder
BACKGROUND: Currently, treatment of latent tuberculosis infection (LTBI) in Australia consists most commonly of a 9-month course of isoniazid (9H). A 3-month course of weekly isoniazid and rifapentine (3HP) has been shown to be as effective as 9 months of daily isoniazid, and associated with less hepatotoxicity; however, rifapentine is not currently available in Australia. Introduction of this regimen would have apparent advantages for people with LTBI in Victoria by safely shortening duration of LTBI therapy...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29163972/prevalence-of-fecal-incontinence-in-a-cohort-of-systemic-sclerosis-patients-within-a-regional-referral-network
#20
A Garros, S Marjoux, C Khouatra, B Coppere, C Grange, A Hot, S Roman, H Damon, F Mion
Background: The prevalence of gastrointestinal involvement in systemic sclerosis is higher than 75%. The estimated prevalence of fecal incontinence varies from 22% to 77%, but suffers from recruitment bias and patient reluctance. Our goal was to evaluate the prevalence of fecal incontinence in systemic sclerosis, and to identify associated risk factors. Methods: Patients were recruited in the referral systemic sclerosis network of the Lyon University Hospitals, using self-administered questionnaires including constipation, fecal incontinence and Bristol Stool scales, quality of life, anxiety and depression...
November 2017: United European Gastroenterology Journal
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