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Damon systems

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https://www.readbyqxmd.com/read/29295825/a-pivotal-phase-iii-randomised-placebo-controlled-study-of-belimumab-in-patients-with-systemic-lupus-erythematosus-located-in-china-japan-and-south-korea
#1
Fengchun Zhang, Sang-Cheol Bae, Damon Bass, Myron Chu, Sally Egginton, David Gordon, David A Roth, Jie Zheng, Yoshiya Tanaka
BACKGROUND: Intravenous belimumab plus standard of care (SoC) is approved in the USA and Europe for treatment of active, autoantibody-positive systemic lupus erythematosus (SLE). METHODS: This phase III, multicentre, randomised, double-blind, placebo-controlled study (BEL113750; NCT01345253) was conducted in 49 centres across China, Japan and South Korea (May 2011-September 2015). Patients with SLE were randomised 2:1 to intravenous belimumab 10 mg/kg or placebo, plus SoC, every 4 weeks until Week 48...
January 2, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29224209/sircle-a-randomised-controlled-cost-comparison-of-self-administered-short-course-isoniazid-and-rifapentine-for-cost-effective-latent-tuberculosis-eradication
#2
Justin T Denholm, Emma S McBryde, Damon Eisen, Alan Street, Elizabeth Matchett, Caroline Chen, Thomas Shultz, Beverly Biggs, Karin Leder
BACKGROUND: Currently, treatment of latent tuberculosis infection (LTBI) in Australia consists most commonly of a 9-month course of isoniazid (9H). A 3-month course of weekly isoniazid and rifapentine (3HP) has been shown to be as effective as 9 months of daily isoniazid, and associated with less hepatotoxicity; however, rifapentine is not currently available in Australia. Introduction of this regimen would have apparent advantages for people with LTBI in Victoria by safely shortening duration of LTBI therapy...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29163972/prevalence-of-fecal-incontinence-in-a-cohort-of-systemic-sclerosis-patients-within-a-regional-referral-network
#3
A Garros, S Marjoux, C Khouatra, B Coppere, C Grange, A Hot, S Roman, H Damon, F Mion
Background: The prevalence of gastrointestinal involvement in systemic sclerosis is higher than 75%. The estimated prevalence of fecal incontinence varies from 22% to 77%, but suffers from recruitment bias and patient reluctance. Our goal was to evaluate the prevalence of fecal incontinence in systemic sclerosis, and to identify associated risk factors. Methods: Patients were recruited in the referral systemic sclerosis network of the Lyon University Hospitals, using self-administered questionnaires including constipation, fecal incontinence and Bristol Stool scales, quality of life, anxiety and depression...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29160347/stability-comparison-of-two-different-dentoalveolar-expansion-treatment-protocols
#4
Ezgi Atik, Tülin Taner
OBJECTIVE: The aim of this study was to compare the longitudinal stability of the conventional straight-wire system after the use of a quad-helix appliance with Damon self-ligating system in patients with Class I malocclusion. METHODS: 27 adolescent patients were evaluated at three different periods: pre-treatment (T1), post-treatment (T2) and three years post-treatment (T3). Group 1 included 12 patients (with a mean age of 14.65 year) treated with Damon 3MX bracket system; and Group 2 included 15 patients (with a mean age of 14...
September 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29061621/detection-and-management-of-familial-hypercholesterolaemia-in-primary-care-in-australia-protocol-for-a-pragmatic-cluster-intervention-study-with-pre-post-intervention-comparisons
#5
Diane E Arnold-Reed, Tom Brett, Lakkhina Troeung, Alistair Vickery, Jacquie Garton-Smith, Damon Bell, Jing Pang, Tegan Grace, Caroline Bulsara, Ian Li, Max Bulsara, Gerald F Watts
INTRODUCTION: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH. METHODS AND ANALYSIS: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29060394/automatic-visual-impairment-detection-system-for-age-related-eye-diseases-through-gaze-analysis
#6
Ai Ping Yow, Damon Wong, Huiying Liu, Hongyuan Zhu, Ivy Jing-Wen Ong, Augustinus Laude, Tock Han Lim
Visual impairment associated with Age-related Macular Degeneration (AMD) often results in a central scotoma which is an alteration in the central vision, leading to distortion or loss of vision. Current methods for assessing visual performance such as Amsler grid and Microperimetry are typically manual and have limitations as an indicator of visual field. In this paper, we present an automated system for detecting visual impairment through gaze tracking (AVIGA). Two types of assessments namely, Impulse Stimuli Response (ISR) test and Pursuit Stimuli Response (PSR) test were implemented in AVIGA system...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057677/effect-of-different-polysorbates-on-development-of-self-microemulsifying-drug-delivery-systems-using-medium-chain-lipids
#7
Ankita Shah, Prajwal Thool, Komal Sorathiya, Hetal Prajapati, Damon Dalrymple, Abu T M Serajuddin
The primary objective of this study was to develop lipid-based self-microemulsifying drug delivery systems (SMEDDS) without using any organic cosolvents that would spontaneously form microemulsions upon dilution with water. Cosolvents were avoided to prevent possible precipitation of drug upon dilution and other stability issues. Different polysorbates, namely, Tween 20, Tween 40, Tween 60, and Tween 80, were used as surfactants, and Captex 355 EP/NF (glycerol tricaprylate/caprate) or its 1:1 mixture with Capmul MCM NF (glycerol monocaprylocaprate) were used as lipids...
October 23, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29036309/chiral-analysis-of-methamphetamine-in-oral-fluid-samples-a-method-to-distinguish-licit-from-illicit-drug-use
#8
Damon Borg, Elizabeth Kolb, Cindy Lantigua, Richard Stripp
Methamphetamine (MAMP) is a popular illicit drug abused for its central nervous system stimulating effects. MAMP is also used therapeutically in the treatment of overeating disorders, narcolepsy, attention deficit disorder, in over-the-counter (OTC) products to ease nasal congestion. MAMP exists in two enantiomeric forms, dextrorotary (d-MAMP) or levorotary (l-MAMP). The compounds are similar in chemical structure, simply differing in the orientation of functional groups around the asymmetric carbon. In part because of the availability of l-MAMP in OTC nasal inhalers, forensic guidelines require a sample to contain greater than 20% d-MAMP to consider illicit drug use when interpreting results...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29033177/arsenic-phosphorus-interactions-in-the-soil-plant-microbe-system-dynamics-of-uptake-suppression-and-toxicity-to-plants
#9
Hossain M Anawar, Zed Rengel, Paul Damon, Mark Tibbett
High arsenic (As) concentrations in the soil, water and plant systems can pose a direct health risk to humans and ecosystems. Phosphate (Pi) ions strongly influence As availability in soil, its uptake and toxicity to plants. Better understanding of As(V)-Pi interactions in soils and plants will facilitate a potential remediation strategy for As contaminated soils, reducing As uptake by crop plants and toxicity to human populations via manipulation of soil Pi content. However, the As(V)-Pi interactions in soil-plant systems are complex, leading to contradictory findings among different studies...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28988646/pembrolizumab-in-advanced-soft-tissue-sarcoma-and-bone-sarcoma-sarc028-a-multicentre-two-cohort-single-arm-open-label-phase-2-trial
#10
RANDOMIZED CONTROLLED TRIAL
Hussein A Tawbi, Melissa Burgess, Vanessa Bolejack, Brian A Van Tine, Scott M Schuetze, James Hu, Sandra D'Angelo, Steven Attia, Richard F Riedel, Dennis A Priebat, Sujana Movva, Lara E Davis, Scott H Okuno, Damon R Reed, John Crowley, Lisa H Butterfield, Ruth Salazar, Jaime Rodriguez-Canales, Alexander J Lazar, Ignacio I Wistuba, Laurence H Baker, Robert G Maki, Denise Reinke, Shreyaskumar Patel
BACKGROUND: Patients with advanced sarcomas have a poor prognosis and few treatment options that improve overall survival. Chemotherapy and targeted therapies offer short-lived disease control. We assessed pembrolizumab, an anti-PD-1 antibody, for safety and activity in patients with advanced soft-tissue sarcoma or bone sarcoma. METHODS: In this two-cohort, single-arm, open-label, phase 2 study, we enrolled patients with soft-tissue sarcoma or bone sarcoma from 12 academic centres in the USA that were members of the Sarcoma Alliance for Research through Collaboration (SARC)...
November 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28980702/detection-of-generalized-tonic-clonic-seizures-using-surface-electromyographic-monitoring
#11
MULTICENTER STUDY
Jonathan J Halford, Michael R Sperling, Dileep R Nair, Dennis J Dlugos, William O Tatum, Jay Harvey, Jacqueline A French, John R Pollard, Edward Faught, Katherine H Noe, Thomas R Henry, Gina M Jetter, Octavian V Lie, Lola C Morgan, Michael R Girouard, Damon P Cardenas, Luke E Whitmire, Jose E Cavazos
OBJECTIVE: A prospective multicenter phase III trial was undertaken to evaluate the performance and tolerability in the epilepsy monitoring unit (EMU) of an investigational wearable surface electromyographic (sEMG) monitoring system for the detection of generalized tonic-clonic seizures (GTCSs). METHODS: One hundred ninety-nine patients with a history of GTCSs who were admitted to the EMU in 11 level IV epilepsy centers for clinically indicated video-electroencephalographic monitoring also received sEMG monitoring with a wearable device that was worn on the arm over the biceps muscle...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/28973088/association-between-immigrant-status-and-end-of-life-care-in-ontario-canada
#12
Christopher J Yarnell, Longdi Fu, Doug Manuel, Peter Tanuseputro, Therese Stukel, Ruxandra Pinto, Damon C Scales, Andreas Laupacis, Robert A Fowler
Importance: People who immigrate face unique health literacy, communication, and system navigation challenges, and they may have diverse preferences that influence end-of-life care. Objective: To examine end-of-life care provided to immigrants to Canada in the last 6 months of their life. Design, Setting, and Participants: This population-based cohort study (April 1, 2004, to March 31, 2015) included 967 013 decedents in Ontario, Canada, using validated linkages between health and immigration databases to identify immigrant (since 1985) and long-standing resident cohorts...
October 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28765720/a-global-map-of-saltmarshes
#13
Chris J Mcowen, Lauren V Weatherdon, Jan-Willem Van Bochove, Emma Sullivan, Simon Blyth, Christoph Zockler, Damon Stanwell-Smith, Naomi Kingston, Corinne S Martin, Mark Spalding, Steven Fletcher
BACKGROUND: Saltmarshes are extremely valuable but often overlooked ecosystems, contributing to livelihoods locally and globally through the associated ecosystem services they provide, including fish production, carbon storage and coastal protection. Despite their importance, knowledge of the current spatial distribution (occurrence and extent) of saltmarshes is incomplete. In light of increasing anthropogenic and environmental pressures on coastal ecosystems, global data on the occurrence and extent of saltmarshes are needed to draw attention to these critical ecosystems and to the benefits they generate for people...
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/28742420/orthodontics-with-customized-versus-noncustomized-appliances-a-randomized-controlled-clinical-trial
#14
E W Penning, R H J Peerlings, J D M Govers, R J Rischen, K Zinad, E M Bronkhorst, K H Breuning, A M Kuijpers-Jagtman
This randomized controlled trial aimed to evaluate the duration and outcome quality of orthodontic treatment with a customized fixed appliance system versus a noncustomized system. Patients ( n = 180) were randomized and received orthodontic treatment with the Insignia customized orthodontic system or the Damon Q noncustomized orthodontic system. The allocation sequence was concealed using identical, sequentially numbered, opaque, sealed envelopes. Patients with nonextraction treatment plans were treated by 2 equally experienced orthodontists...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732167/quantum-transport-and-sub-band-structure-of-modulation-doped-gaas-alas-core-superlattice-nanowires
#15
Dominik M Irber, Jakob Seidl, Damon J Carrad, Jonathan Becker, Nari Jeon, Bernhard Loitsch, Julia Winnerl, Sonja Matich, Markus Döblinger, Yang Tang, Stefanie Morkötter, Gerhard Abstreiter, Jonathan J Finley, Matthew Grayson, Lincoln J Lauhon, Gregor Koblmüller
Modulation-doped III-V semiconductor nanowire (NW) heterostructures have recently emerged as promising candidates to host high-mobility electron channels for future high-frequency, low-energy transistor technologies. The one-dimensional geometry of NWs also makes them attractive for studying quantum confinement effects. Here, we report correlated investigations into the discrete electronic sub-band structure of confined electrons in the channel of Si δ-doped GaAs-GaAs/AlAs core-superlattice NW heterostructures and the associated signatures in low-temperature transport...
July 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28720450/detection-of-cervical-precancerous-lesions-with-aptima-hpv-assays-using-surepath-preservative-fluid-specimens
#16
Max Chernesky, Dan Jang, Nick Escott, Jodi Gilchrist, Jenny Li, Laurie Elit, Alice Lytwyn, Marek Smieja, Sam Ratnam, Manuel Arias, Damon Getman, Barbara Weinbaum, Brett Kirkconnell, Janel Dockter
SurePath specimens from women referred to colposcopy were treated with Aptima Transfer Solution (ATS) before testing in Aptima HPV (AHPV) and Aptima HPV 16, 18/45 (AHPV-GT) assays. Untreated SurePath specimens were tested with the cobas HPV test. PreservCyt specimens were assessed for cytology and tested with AHPV. High-grade cervical intraepithelial neoplasia lesions served as the reference standard. Excellent agreement (95.5%; k=0.91) was observed for ATS-treated SurePath specimens between Tigris and Panther systems and between the PreservCyt and ATS-treated SurePath specimens (91...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28696746/coherent-plasmon-and-phonon-plasmon-resonances-in-carbon-nanotubes
#17
Abram L Falk, Kuan-Chang Chiu, Damon B Farmer, Qing Cao, Jerry Tersoff, Yi-Hsien Lee, Phaedon Avouris, Shu-Jen Han
Carbon nanotubes provide a rare access point into the plasmon physics of one-dimensional electronic systems. By assembling purified nanotubes into uniformly sized arrays, we show that they support coherent plasmon resonances, that these plasmons couple to nanotube and substrate phonons, and that the resulting phonon-plasmon resonances have quality factors as high as 10. Because nanotube plasmons intensely strengthen electromagnetic fields and light-matter interactions, they provide a compelling platform for surface-enhanced spectroscopy and tunable optical devices at deep-subwavelength scales...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28651927/doxorubicin-plus-evofosfamide-versus-doxorubicin-alone-in-locally-advanced-unresectable-or-metastatic-soft-tissue-sarcoma-th-cr-406-sarc021-an-international-multicentre-open-label-randomised-phase-3-trial
#18
RANDOMIZED CONTROLLED TRIAL
William D Tap, Zsuzsanna Papai, Brian A Van Tine, Steven Attia, Kristen N Ganjoo, Robin L Jones, Scott Schuetze, Damon Reed, Sant P Chawla, Richard F Riedel, Anders Krarup-Hansen, Maud Toulmonde, Isabelle Ray-Coquard, Peter Hohenberger, Giovanni Grignani, Lee D Cranmer, Scott Okuno, Mark Agulnik, William Read, Christopher W Ryan, Thierry Alcindor, Xavier F Garcia Del Muro, G Thomas Budd, Hussein Tawbi, Tillman Pearce, Stew Kroll, Denise K Reinke, Patrick Schöffski
BACKGROUND: Evofosfamide is a hypoxia-activated prodrug of bromo-isophosphoramide mustard. We aimed to assess the benefit of adding evofosfamide to doxorubicin as first-line therapy for advanced soft-tissue sarcomas. METHODS: We did this international, open-label, randomised, phase 3, multicentre trial (TH CR-406/SARC021) at 81 academic or community investigational sites in 13 countries. Eligible patients were aged 15 years or older with a diagnosis of an advanced unresectable or metastatic soft-tissue sarcoma, of intermediate or high grade, for which no standard curative therapy was available, an Eastern Cooperative Oncology Group performance status of 0-1, and measurable disease by Response Evaluation Criteria in Solid Tumors version 1...
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28438227/characterization-of-carbon-monoxide-exposure-during-hurricane-sandy-and-subsequent-nor-easter
#19
Amy Schnall, Royal Law, Amy Heinzerling, Kanta Sircar, Scott Damon, Fuyuen Yip, Josh Schier, Tesfaye Bayleyegn, Amy Wolkin
OBJECTIVE: Carbon monoxide (CO) is an odorless, colorless gas produced by fossil fuel combustion. On October 29, 2012, Hurricane Sandy moved ashore near Atlantic City, New Jersey, causing widespread morbidity and mortality, $30 to $50 billion in economic damage, and 8.5 million households to be without power. The combination of power outages and unusually low temperatures led people to use alternate power sources, placing many at risk for CO exposure. METHODS: We examined Hurricane Sandy-related CO exposures from multiple perspectives to help identify risk factors and develop strategies to prevent future exposures...
April 25, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28390395/myoepithelial-carcinoma-with-rb1-mutation-remarkable-chemosensitivity-to-carcinoma-of-unknown-origin-therapy
#20
Timothy M Hoggard, Evita Henderson-Jackson, Marilyn M Bui, Jamie Caracciolo, Jamie K Teer, Sean Yoder, Odion Binitie, Ricardo J Gonzalez, Andrew S Brohl, Damon R Reed
BACKGROUND: Myoepithelial carcinoma of soft tissue is a rare, malignant neoplasm that is morphologically and immunophenotypically similar to its counterpart in salivary gland. It demonstrates myoepithelial differentiation, possessing both epithelial and myogenic characteristics. Thought to be chemotherapy insensitive, the optimal treatment regimen of this tumor has yet to be established and only a select few cases in the literature discuss treatment efficacy in detail. CASE PRESENTATION: Here we present a case of a young adult with metastatic myoepithelial carcinoma with an initial excellent response to systemic therapy utilizing carboplatin and paclitaxel with continued complete response after 3 years...
April 8, 2017: BMC Cancer
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