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https://www.readbyqxmd.com/read/27890512/safety-and-efficacy-of-valve-repositioning-during-transcatheter-aortic-valve-replacement-with-the-lotus-valve-system
#1
Hashrul N Z Rashid, Robert Gooley, Liam McCormick, Sarah Zaman, Satish Ramkumar, Damon Jackson, Ameera Amiruddin, Arthur Nasis, James Cameron, Ian T Meredith
OBJECTIVE: To determine the safety and efficacy of valve repositioning following transcatheter aortic valve replacement (TAVR) with the Lotus Valve System (Boston Scientific, Marlborough, MA, USA). INTRODUCTION: TAVR is a well-established treatment for severe aortic stenosis. The Lotus Valve System is fully repositionable and retrievable. Valve repositioning has the potential to minimize TAVR-related complications caused by valve malposition; however, the effect on adverse event rates such as stroke is unknown...
November 24, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27863809/efficacy-and-safety-of-tau-aggregation-inhibitor-therapy-in-patients-with-mild-or-moderate-alzheimer-s-disease-a-randomised-controlled-double-blind-parallel-arm-phase-3-trial
#2
Serge Gauthier, Howard H Feldman, Lon S Schneider, Gordon K Wilcock, Giovanni B Frisoni, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Damon J Wischik, Bjoern O Schelter, Charles S Davis, Roger T Staff, Luc Bracoud, Kohkan Shamsi, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: Leuco-methylthioninium bis(hydromethanesulfonate; LMTM), a stable reduced form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mouse models. Methylthioninium chloride has previously shown potential efficacy as monotherapy in patients with Alzheimer's disease. We aimed to determine whether LMTM was safe and effective in modifying disease progression in patients with mild to moderate Alzheimer's disease...
November 15, 2016: Lancet
https://www.readbyqxmd.com/read/27862860/incidence-and-predictors-of-permanent-pacemaker-implantation-following-treatment-with-the-repositionable-lotus%C3%A2-transcatheter-aortic-valve
#3
Sarah Zaman, Liam McCormick, Robert Gooley, Hashrul Rashid, Satish Ramkumar, Damon Jackson, Samuel Hui, Ian T Meredith
OBJECTIVES: To determine the incidence and predictors of permanent pacemaker (PPM) requirement following transcatheter aortic valve replacement (TAVR) with the mechanically expanded Lotus(TM) Valve System (Boston Scientific). BACKGROUND: Pacemaker implantation is the most common complication following TAVR. Predictors of pacing following TAVR with the Lotus valve have not been systematically assessed. METHODS: Consecutive patients with severe aortic stenosis who underwent Lotus valve implantation were prospectively recruited at a single-centre...
November 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27780048/parallel-computations-in-insect-and-mammalian-visual-motion-processing
#4
REVIEW
Damon A Clark, Jonathan B Demb
Sensory systems use receptors to extract information from the environment and neural circuits to perform subsequent computations. These computations may be described as algorithms composed of sequential mathematical operations. Comparing these operations across taxa reveals how different neural circuits have evolved to solve the same problem, even when using different mechanisms to implement the underlying math. In this review, we compare how insect and mammalian neural circuits have solved the problem of motion estimation, focusing on the fruit fly Drosophila and the mouse retina...
October 24, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27767044/direct-analysis-and-quantification-of-metaldehyde-in-water-using-reactive-paper-spray-mass-spectrometry
#5
Simon Maher, Fred P M Jjunju, Deidre E Damon, Hannah Gorton, Yosef S Maher, Safaraz U Syed, Ron M A Heeren, Iain S Young, Stephen Taylor, Abraham K Badu-Tawiah
Metaldehyde is extensively used worldwide as a contact and systemic molluscicide for controlling slugs and snails in a wide range of agricultural and horticultural crops. Contamination of surface waters due to run-off, coupled with its moderate solubility in water, has led to increased concentration of the pesticide in the environment. In this study, for the first time, rapid analysis (<~1 minute) of metaldehyde residues in water is demonstrated using paper spray mass spectrometry (PS-MS). The observed precursor molecular ions of metaldehyde were confirmed from tandem mass spectrometry (MS/MS) experiments by studying the fragmentation patterns produced via collision-induced dissociation...
October 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27659556/brief-isoflurane-anaesthesia-affects-differential-gene-expression-gene-ontology-and-gene-networks-in-rat-brain
#6
Damon A Lowes, Helen F Galley, Alessandro P S Moura, Nigel R Webster
Much is still unknown about the mechanisms of effects of even brief anaesthesia on the brain and previous studies have simply compared differential expression profiles with and without anaesthesia. We hypothesised that network analysis, in addition to the traditional differential gene expression and ontology analysis, would enable identification of the effects of anaesthesia on interactions between genes. Rats (n=10 per group) were randomised to anaesthesia with isoflurane in oxygen or oxygen only for 15min, and 6h later brains were removed...
September 19, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27658654/the-impact-of-hospital-experience-with-out-of-hospital-cardiac-arrest-patients-on-post-cardiac-arrest-care
#7
Heather Worthington, Will Pickett, Laurie J Morrison, Damon C Scales, Chun Zhan, Steve Lin, Paul Dorian, Katie N Dainty, Niall D Ferguson, Steven C Brooks
OBJECTIVE: Patient volume as a surrogate for institutional experience has been associated with quality of care indicators for a variety of illnesses. We evaluated the association between hospital experience with comatose out-of-hospital cardiac arrest (OHCA) patients and important care processes. METHODS: This was a population-based, retrospective cohort study using data from 37 hospitals in Southern Ontario from 2007 to 2013. We included adults with atraumatic OHCA who were comatose on emergency department arrival and survived at least 6h...
September 20, 2016: Resuscitation
https://www.readbyqxmd.com/read/27621408/picasso-iii-a-phase-iii-placebo-controlled-study-of-doxorubicin-with-or-without-palifosfamide-in-patients-with-metastatic-soft-tissue-sarcoma
#8
Christopher W Ryan, Ofer Merimsky, Mark Agulnik, Jean-Yves Blay, Scott M Schuetze, Brian A Van Tine, Robin L Jones, Anthony D Elias, Edwin Choy, Thierry Alcindor, Vicki L Keedy, Damon R Reed, Robert N Taub, Antoine Italiano, Xavier Garcia Del Muro, Ian R Judson, Jill Y Buck, Francois Lebel, Jonathan J Lewis, Robert G Maki, Patrick Schöffski
PURPOSE: Palifosfamide is the active metabolite of ifosfamide and does not require prodrug activation, thereby avoiding the generation of toxic metabolites. The PICASSO III trial compared doxorubicin plus palifosfamide with doxorubicin plus placebo in patients who had received no prior systemic therapy for metastatic soft tissue sarcoma. PATIENTS AND METHODS: Patients were randomly assigned 1:1 to receive doxorubicin 75 mg/m(2) intravenously day 1 plus palifosfamide 150 mg/m(2)/d intravenously days 1 to 3 or doxorubicin plus placebo once every 21 days for up to six cycles...
September 12, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27586260/direct-observation-of-interfacial-dzyaloshinskii-moriya-interaction-from-asymmetric-spin-wave-propagation-in-w-cofeb-sio2-heterostructures-down-to-sub-nanometer-cofeb-thickness
#9
Avinash Kumar Chaurasiya, Chandrima Banerjee, Santanu Pan, Sourav Sahoo, Samiran Choudhury, Jaivardhan Sinha, Anjan Barman
Interfacial Dzyaloshinskii-Moriya interaction (IDMI) is important for its roles in stabilizing the skyrmionic lattice as well as soliton-like domain wall motion leading towards new generation spintronic devices. However, achievement and detection of IDMI is often hindered by various spurious effects. Here, we demonstrate the occurrence of IDMI originating primarily from W/CoFeB interface in technologically important W/CoFeB/SiO2 heterostructures using Brillouin light scattering technique. Due to the presence of IDMI, we observe asymmetry in the peak frequency and linewidth of the spin-wave spectra in the Damon-Eshbach (DE) geometry at finite k wave-vectors...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27568861/nicotinic-receptor-subtypes-differentially-modulate-glutamate-release-in-the-dorsal-medial-striatum
#10
William M Howe, Damon A Young, George Bekheet, Rouba Kozak
The dorsal medial striatum is a crucial part of the neural network that subserves dynamic, goal-directed behaviors. Functional output of this nucleus is shaped, in part, by the influence of glutamatergic inputs. Striatal cholinergic systems have the capacity to modulate these excitatory inputs through presynaptic nicotinic acetylcholine receptors (nAChRs); however, the individual contribution of the two major nicotinic receptor subtypes, α4β2 and α7, to such modulation is not well characterized. In the present experiments, glutamate biosensors were used to monitor nAChR-dependent glutamate release with high temporal precision in the dorsal medial striatum of rats...
August 26, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27510321/mesenchymal-stem-cells-enhance-nerve-regeneration-in-a-rat-sciatic-nerve-repair-and-hindlimb-transplant-model
#11
Damon S Cooney, Eric G Wimmers, Zuhaib Ibrahim, Johanna Grahammer, Joani M Christensen, Gabriel A Brat, Lehao W Wu, Karim A Sarhane, Joseph Lopez, Christoph Wallner, Georg J Furtmüller, Nance Yuan, John Pang, Kakali Sarkar, W P Andrew Lee, Gerald Brandacher
This study investigates the efficacy of local and intravenous mesenchymal stem cell (MSC) administration to augment neuroregeneration in both a sciatic nerve cut-and-repair and rat hindlimb transplant model. Bone marrow-derived MSCs were harvested and purified from Brown-Norway (BN) rats. Sciatic nerve transections and repairs were performed in three groups of Lewis (LEW) rats: negative controls (n = 4), local MSCs (epineural) injection (n = 4), and systemic MSCs (intravenous) injection (n = 4)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27479957/dynamic-electrical-source-imaging-desi-of-seizures-and-interictal-epileptic-discharges-without-ensemble-averaging
#12
Burak Erem, Damon E Hyde, Jurriaan M Peters, Frank H Duffy, Simon K Warfield
We propose an algorithm for electrical source imaging of epileptic discharges that takes a data-driven approach to regularizing the dynamics of solutions. The method is based on linear system identification on short time segments, combined with a classical inverse solution approach. Whereas ensemble averaging of segments or epochs discards inter-segment variations by averaging across them, our approach explicitly models them. Indeed, it may even be possible to avoid the need for the time-consuming process of marking epochs containing discharges altogether...
July 27, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27365168/external-root-resorption-with-the-self-ligating-damon-system-a-retrospective-study
#13
Roberta Heiffig Handem, Guilherme Janson, Murilo Matias, Karina Maria Salvatore de Freitas, Darwin Vaz de Lima, Daniela Gamba Garib, Marcos Roberto de Freitas
BACKGROUND: The aim of this study was to compare the degree of external apical root resorption (EARR) in patients treated with self-ligating Damon appliances and with conventional preadjusted appliances. METHODS: The sample comprised 52 patients, divided into two groups. Group 1 consisted of 25 patients treated with self-ligating Damon appliances, with an initial age of 16.04 years, final age of 18.06 years, and treatment time of 2.02 years. Group 2 consisted of 27 patients, treated with conventional preadjusted appliances, with an initial age of 16...
December 2016: Progress in Orthodontics
https://www.readbyqxmd.com/read/27328127/cytotoxicity-assessment-of-lipid-based-self-emulsifying-drug-delivery-system-with-caco-2-cell-model-cremophor-el-as-the-surfactant
#14
Pengli Bu, Silpa Narayanan, Damon Dalrymple, Xingguo Cheng, Abu T M Serajuddin
PURPOSE: Caco-2 cells are used extensively for in vitro prediction of intestinal drug absorption. However, toxicity of excipients and formulations used can artificially increase drug permeation by damaging cell monolayers, thus providing misleading results. The present study aimed to investigate cytotoxicity of common lipid-based excipients and formulations on Caco-2 cells. METHODS: Medium-chain monoglycerides alone or in mixture with the surfactant Cremophor EL, with and without a medium-chain triglyceride, were prepared and incubated with Caco-2 cells from a series of culture stages with varying maturity...
August 25, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27324022/identification-of-clinically-achievable-combination-therapies-in-childhood-rhabdomyosarcoma
#15
Elliot Kahen, Diana Yu, Douglas J Harrison, Justine Clark, Pooja Hingorani, Christopher L Cubitt, Damon R Reed
PURPOSE: Systemic therapy has improved rhabdomyosarcoma event-free and overall survival; however, approximately 40 % of patients will have progressive or recurrent disease which is difficult to cure and remains a considerable challenge. Minimal progress has been made in improving outcomes for metastatic or relapsed RMS due to a lack of effective therapeutic agents. Targeted therapies are likely to be incorporated into regimens which rely on conventional cytotoxic chemotherapy. A system to evaluate novel combinations of interest is needed...
August 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27267735/energetic-salts-based-on-3-5-bis-dinitromethyl-1-2-4-triazole-monoanion-and-dianion-controllable-preparation-characterization-and-high-performance
#16
Jiaheng Zhang, Srinivas Dharavath, Lauren A Mitchell, Damon A Parrish, Jean'ne M Shreeve
Molecular modification of known explosives is considered to be an efficient route to design new energetic materials. A new family of energetic salts based on the 3,5-bis(dinitromethyl)-1,2,4-triazole monoanion and dianion were controllably synthesized by using 1-diamino-2,2-dinitroethene as a precursor. X-ray structure determination of monohydrazinium 3,5-bis(dinitromethyl)-1,2,4-triazolate (5) and monoammonium (6) and diammonium 3,5-bis(dinitromethyl)-1,2,4-triazolate hydrate (8·H2O) further confirmed the structures of these anions...
June 22, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27229624/ocean-acidification-reverses-the-positive-effects-of-seawater-ph-fluctuations-on-growth-and-photosynthesis-of-the-habitat-forming-kelp-ecklonia-radiata
#17
Damon Britton, Christopher E Cornwall, Andrew T Revill, Catriona L Hurd, Craig R Johnson
Ocean acidification (OA) is the reduction in seawater pH due to the absorption of human-released CO2 by the world's oceans. The average surface oceanic pH is predicted to decline by 0.4 units by 2100. However, kelp metabolically modifies seawater pH via photosynthesis and respiration in some temperate coastal systems, resulting in daily pH fluctuations of up to ±0.45 units. It is unknown how these fluctuations in pH influence the growth and physiology of the kelp, or how this might change with OA. In laboratory experiments that mimicked the most extreme pH fluctuations measured within beds of the canopy-forming kelp Ecklonia radiata in Tasmania, the growth and photosynthetic rates of juvenile E...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27223687/face-detection-and-the-development-of-own-species-bias-in-infant-macaques
#18
Elizabeth A Simpson, Krisztina V Jakobsen, Fabrice Damon, Stephen J Suomi, Pier F Ferrari, Annika Paukner
In visually complex environments, numerous items compete for attention. Infants may exhibit attentional efficiency-privileged detection, attention capture, and holding-for face-like stimuli. However, it remains unknown when these biases develop and what role, if any, experience plays in this emerging skill. Here, nursery-reared infant macaques' (Macaca mulatta; n = 10) attention to faces in 10-item arrays of nonfaces was measured using eye tracking. With limited face experience, 3-week-old monkeys were more likely to detect faces and looked longer at faces compared to nonfaces, suggesting a robust face detection system...
May 25, 2016: Child Development
https://www.readbyqxmd.com/read/27176304/extensions-to-a-manifold-learning-framework-for-time-series-analysis-on-dynamic-manifolds-in-bioelectric-signals
#19
Burak Erem, Ramon Martinez Orellana, Damon E Hyde, Jurriaan M Peters, Frank H Duffy, Petr Stovicek, Simon K Warfield, Rob S MacLeod, Gilead Tadmor, Dana H Brooks
This paper addresses the challenge of extracting meaningful information from measured bioelectric signals generated by complex, large scale physiological systems such as the brain or the heart. We focus on a combination of the well-known Laplacian eigenmaps machine learning approach with dynamical systems ideas to analyze emergent dynamic behaviors. The method reconstructs the abstract dynamical system phase-space geometry of the embedded measurements and tracks changes in physiological conditions or activities through changes in that geometry...
April 2016: Physical Review. E
https://www.readbyqxmd.com/read/27132463/current-state-of-pediatric-sarcoma-biology-and-opportunities-for-future-discovery-a-report-from-the-sarcoma-translational-research-workshop
#20
REVIEW
Pooja Hingorani, Katherine Janeway, Brian D Crompton, Cigall Kadoch, Crystal L Mackall, Javed Khan, Jack F Shern, Joshua Schiffman, Lisa Mirabello, Sharon A Savage, Marc Ladanyi, Paul Meltzer, Carol J Bult, Peter C Adamson, Philip J Lupo, Rajen Mody, Steven G DuBois, D Williams Parsons, Chand Khanna, Ching Lau, Douglas S Hawkins, R Lor Randall, Malcolm Smith, Poul H Sorensen, Sharon E Plon, Stephen X Skapek, Stephen Lessnick, Richard Gorlick, Damon R Reed
Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time...
May 2016: Cancer Genetics
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