Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau Florea, Ruba N Shalhoub, Pedro Emilio Alcedo Andrade, Khanh Nghiem, Marcela A Ferrada, Alexander Hines, Kaitlin A Quinn, Sumith R Panicker, Amanda K Ombrello, Kaaren K Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra L Lasho, Daniel L Kastner, Kenneth J Warrington, Abhishek A Mangaonkar, Ronald S Go, Raul C Braylan, David B Beck, Mrinal M Patnaik, Neal S Young, Katherine R Calvo, Ana Casanegra, Peter C Grayson, Matthew J Koster, Colin O Wu, Yogendra Kanthi, Bhavisha A Patel, Damon E Houghton, Emma M Groarke
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, caused by somatic mutations in UBA1, is an autoinflammatory disorder with diverse systemic manifestations. Thrombosis is a prominent clinical feature of VEXAS. The risks factors and frequency of thrombosis in VEXAS are not well described, due to the disease's new discovery and paucity of large databases. We evaluated 119 VEXAS patients for venous and arterial thrombosis and correlated their presence with clinical outcomes and survival...
February 2, 2024: Blood