keyword
MENU ▼
Read by QxMD icon Read
search

Expansion

keyword
https://www.readbyqxmd.com/read/29161249/genetic-code-expansion-synthetases-pick-up-the-pace
#1
Jeffery M Tharp, Wenshe R Liu
No abstract text is available yet for this article.
November 21, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29161179/synergistic-induction-of-apoptosis-by-quercetin-and-curcumin-in-chronic-myeloid-leukemia-k562-cells
#2
Ergül Mutlu Altundağ, Ayşe Mine Yılmaz, Semra Koçtürk, Yavuz Taga, A Suha Yalçın
Chronic myeloid leukemia is a major hematopoietic malignancy characterized by expansion of myeloid cells. In this study, we have investigated whether quercetin, curcumin and their combination induce apoptosis and inhibit growth of K562 cells. We have observed that quercetin and curcumin combination induced apoptosis accompanied by increased ROS and decreased GSH levels as well as loss of mitochondrial membrane potential. Our mRNA and protein expression results suggested that cytochrome c was released from mitochondria causing PARP and caspase-9 cleavages, the hallmarks of mitochondrial apoptotic pathway...
November 21, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29161157/event-specific-cannabis-use-and-cannabis-use-motives
#3
Julia D Buckner, Katherine A Walukevich, Amber M Henslee
BACKGROUND: Specific events such as Mardi Gras (MG) and St. Patrick's Day (SPD) have been identified as high-risk events for cannabis use. Further, some campuses may have traditions that are associated with more event-specific cannabis use. OBJECTIVES: Campus A has specific traditions regarding MG whereas Campus B has specific traditions regarding SPD and these campuses are differentially related to event-specific cannabis use (Buckner, Henslee, & Jeffries, 2015 )...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29161051/a-new-avenue-for-limiting-degradation-in-nanoli4ti5o12-for-ultra-fast-charge-lithium-ion-batteries-hybrid-polymer-inorganic-particles
#4
Jean-Christophe Daigle, Yuichiro Asakawa, Mélanie Beaupré, René Vieillette, Dharminder Laul, Michel L Trudeau, Karim Zaghib
Lithium titanium oxide (Li4Ti5O12)-based cells are a very promising battery technology for ultra-fast charge-discharge and long-life cycle batteries. However, surface reactivity of lithium titanium oxide is still a problem in presence of organic electrolyte which may cause expansion of the pouch cell. In this study, we report on the development of a simple and economical ''grafting onto'' method for forming hybrid polymer-Li4Ti15O12 nanoparticles which can be successfully applied in lithium-ion batteries. This method utilizes a low-cost and scalable hydrophobic polymer which is required for industrial implantation...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29161048/local-chemical-ordering-and-negative-thermal-expansion-in-ptni-alloy-nanoparticles
#5
Qiang Li, He Zhu, Li Rong Zheng, Longlong Fan, Na Wang, Yangchun Rong, Yang Ren, Jun Chen, Jinxia Deng, Xianran Xing
An atomic insight into the local chemical ordering and lattice strain is particular interesting to recent emerging bimetallic nanocatalysts such as PtNi alloys. Here, we reported the atomic distribution, chemical environment and lattice thermal evolution in full-scale structural description of PtNi alloy nanoparticles (NPs). The different segregation of elements in the well-faceted PtNi nanoparticles is convinced by extended X-ray absorption fine structure (EXAFS). Atomic pair distribution function (PDF) study evidences the co-existence of the face-centered cubic and tetragonal ordering parts in the local environment of PtNi nanoparticles...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29160864/clonal-expansion-behind-a-marine-diatom-bloom
#6
Maria Valeria Ruggiero, Domenico D'Alelio, Maria Immacolata Ferrante, Mariano Santoro, Laura Vitale, Gabriele Procaccini, Marina Montresor
Genetic diversity is what selection acts on, thus shaping the adaptive potential of populations. We studied micro-evolutionary patterns of the key planktonic diatom Pseudo-nitzschia multistriata at a long-term sampling site over 2 consecutive years by genotyping isolates with 22 microsatellite markers. We show that both sex and vegetative growth interplay in shaping intraspecific diversity. We document a brief but massive demographic and clonal expansion driven by strains of the same mating type. The analysis of an extended data set (6 years) indicates that the genetic fingerprint of P...
November 21, 2017: ISME Journal
https://www.readbyqxmd.com/read/29160844/altered-aconitase-2-activity-in-huntington-s-disease-peripheral-blood-cells-and-mouse-model-striatum
#7
Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang
Huntington's disease (HD) is caused by an unstable cytosine adenine guanine (CAG) trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin protein. Previously, we identified several up- and down-regulated protein molecules in the striatum of the Hdh((CAG)150) knock-in mice at 16 months of age, a mouse model which is modeling the early human HD stage. Among those molecules, aconitase 2 (Aco2) located in the mitochondrial matrix is involved in the energy generation and susceptible to increased oxidative stress that would lead to inactivation of Aco2 activity...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160813/homoeologous-recombination-of-the-v1r1-v1r2-gene-cluster-of-pheromone-receptors-in-an-allotetraploid-lineage-of-teleosts
#8
Lei Zhong, Weimin Wang
In contrast to other olfactory receptor families that exhibit frequent lineage-specific expansions, the vomeronasal type 1 receptor (V1R) family exhibits a canonical six-member repertoire in teleosts. V1r1 and V1r2 are present in no more than one copy in all examined teleosts, including salmons, which are ancient polyploids, implying strict evolutionary constraints. However, recent polyploids have not been examined. Here, we identified a young allotetraploid lineage of weatherfishes and investigated their V1r1-V1r2 cluster...
November 21, 2017: Genes
https://www.readbyqxmd.com/read/29160776/proton-range-verification-in-homogeneous-materials-through-acoustic-measurements
#9
Wei Nie, Kevin C Jones, Scott Petro, Alireza Kassaee, Chandra M Sehgal, Stephen Avery
Clinical proton beam quality assurance (QA) requires a simple and accurate method to measure the proton beam Bragg peak (BP) depth. Protoacoustics, the measurement of the pressure waves emitted by thermal expansion resulting from proton dose deposition, may be used to obtain the depth of the BP in a phantom by measuring the time-of-flight (TOF) of the pressure wave. Rectangular and cylindrical phantoms of different materials (aluminum, lead, and polyethylene) were used for protoacoustic studies. Four different methods for analyzing the protoacoustic signals are compared...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160510/changes-in-the-epidemiology-of-visceral-leishmaniasis-in-brazil-from-2001-to-2014
#10
Lisiane Lappe Dos Reis, Antônio Alcirley da Silva Balieiro, Fernanda Rodrigues Fonseca, Maria Jacirema Ferreira Gonçalves
INTRODUCTION: Visceral leishmaniasis (VL) is a neglected disease, with territorial expansion and regional differences in Brazil that require explanation. This study aimed to describe changes in the epidemiology of VL in Brazil from 2001 to 2014. METHODS: The incidence rates, sociodemographic and clinical data, and case evolution were subgrouped from 2001 to 2006 and from 2007 to 2014 and presented descriptively. Spatial distribution of disease incidence rates and changes in the spatial and temporal pattern were examined...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160456/infrastructure-of-pharmacies-of-the-primary-health-care-in-the-brazilian-unified-health-system-analysis-of-pnaum-services-data
#11
Silvana Nair Leite, Fernanda Manzini, Juliana Álvares, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mário Soeiro, Mareni Rocha Farias
OBJECTIVE: To characterize the infrastructure of the primary health care pharmacies of the Brazilian Unified Health System, aiming at humanizing the offered services. METHODS: This is a cross-sectional study, of quantitative approach, from data obtained in the Pesquisa Nacional de Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015)...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160347/stability-comparison-of-two-different-dentoalveolar-expansion-treatment-protocols
#12
Ezgi Atik, Tülin Taner
OBJECTIVE: The aim of this study was to compare the longitudinal stability of the conventional straight-wire system after the use of a quad-helix appliance with Damon self-ligating system in patients with Class I malocclusion. METHODS: 27 adolescent patients were evaluated at three different periods: pre-treatment (T1), post-treatment (T2) and three years post-treatment (T3). Group 1 included 12 patients (with a mean age of 14.65 year) treated with Damon 3MX bracket system; and Group 2 included 15 patients (with a mean age of 14...
September 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29159785/improving-the-hospital-quality-of-care-during-winter-periods-by-optimizing-budget-allocation-between-rotavirus-vaccination-and-bed-expansion
#13
Thibaut Dort, Nadia Schecroun, Baudouin Standaert
BACKGROUND: During each winter the hospital quality of care (QoC) in pediatric wards decreases due to a surge in pediatric infectious diseases leading to overcrowded units. Bed occupancy rates often surpass the good hospital bed management threshold of 85%, which can result in poor conditions in the workplace. This study explores how QoC-scores could be improved by investing in additional beds and/or better vaccination programs against vaccine-preventable infectious diseases. METHODS: The Cobb-Douglas model was selected to define the improvement in QoC (%) as a function of two strategies (rotavirus vaccination coverage [%] and addition of extra hospital beds [% of existing beds]), allowing improvement-isocurves to be produced...
November 20, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29159541/automated-detection-of-exudative-age-related-macular-degeneration-in-spectral-domain-optical-coherence-tomography-using-deep-learning
#14
Maximilian Treder, Jost Lennart Lauermann, Nicole Eter
PURPOSE: Our purpose was to use deep learning for the automated detection of age-related macular degeneration (AMD) in spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 1112 cross-section SD-OCT images of patients with exudative AMD and a healthy control group were used for this study. In the first step, an open-source multi-layer deep convolutional neural network (DCNN), which was pretrained with 1.2 million images from ImageNet, was trained and validated with 1012 cross-section SD-OCT scans (AMD: 701; healthy: 311)...
November 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29159500/comparative-analysis-of-molecular-activity-in-dermal-mesenchymal-stem-cells-from-different-passages
#15
Xinhua Li, Junqin Li, Xincheng Zhao, Qiang Wang, Xiaohong Yang, Yueai Cheng, Min Zhou, Gang Wang, Erle Dang, Xiaoli Yang, Ruixia Hou, Peng An, Guohua Yin, Kaiming Zhang
Mesenchymal stem cells (MSCs) are used for tissue regeneration in several pathological conditions, including autoimmune diseases. However, the optimal sources and culture requirements for these cells are still under investigation. Here, we compared mRNA expression in dermal MSCs (DMSCs) at passage (P) 3 and P5 to provide a reference for future studies related to DMSCs expansion. In normal DMSCs, the expression of three of eight genes associated with basic cellular activity were different at P5 compared to that at P3: PLCB4 and SYTL2 were upregulated by 4...
November 20, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29159312/perceived-parental-attitudes-of-gender-expansiveness-development-and-preliminary-factor-structure-of-a-self-report-youth-questionnaire
#16
Marco A Hidalgo, Diane Chen, Robert Garofalo, Catherine Forbes
Purpose: Parental acceptance of gender identity/expression in lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ+) youth moderates the effects of minority stress on mental health outcomes. Given this association, mental health clinicians of gender-expansive adolescents often assess the degree to which these youth perceive their parents/primary caregivers as accepting or nonaffirming of their gender identity and expression. While existing measures may reliably assess youth's perceptions of general family support, no known tool aids in the assessment an adolescent's perceived parental support related to adolescent gender-expansive experiences...
2017: Transgender Health
https://www.readbyqxmd.com/read/29159287/strained-hybrid-perovskite-thin-films-and-their-impact-on-the-intrinsic-stability-of-perovskite-solar-cells
#17
Jingjing Zhao, Yehao Deng, Haotong Wei, Xiaopeng Zheng, Zhenhua Yu, Yuchuan Shao, Jeffrey E Shield, Jinsong Huang
Organic-inorganic hybrid perovskite (OIHP) solar cells have achieved comparable efficiencies to those of commercial solar cells, although their instability hinders their commercialization. Although encapsulation techniques have been developed to protect OIHP solar cells from external stimuli such as moisture, oxygen, and ultraviolet light, understanding of the origin of the intrinsic instability of perovskite films is needed to improve their stability. We show that the OIHP films fabricated by existing methods are strained and that strain is caused by mismatched thermal expansion of perovskite films and substrates during the thermal annealing process...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29159191/soluble-cd163-in-intracerebral-hemorrhage-biomarker-for-perihematomal-edema
#18
Meaghan Roy-O'Reilly, Liang Zhu, Louise Atadja, Glenda Torres, Jaroslaw Aronowski, Louise McCullough, Nancy J Edwards
Objective: Patients with intracerebral hemorrhage (ICH) may elaborate varying degrees of perihematomal edema (PHE), requiring closer monitoring and a higher intensity of treatment. Here, we explore whether the soluble form of CD163, a scavenger receptor responsible for hemoglobin sequestration, can serve as a prognostic biomarker of PHE development and poor outcome after ICH. Methods: Our study cohort was comprised of 51 primary age- and sex-matched ICH patients with moderate-sized, hypertensive deep hemorrhages...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29159074/only-some-patients-with-bulbar-and-spinal-muscular-atrophy-may-develop-cardiac-disease
#19
Josef Finsterer, Claudia Stöllberger
Objectives: According to recent publications, some patients with spinal and bulbar muscular atrophy (BSMA) develop cardiac disease, manifesting as ST-segment abnormalities, Brugada-syndrome, dilative cardiomyopathy, or sudden cardiac death. Here we present neurological and cardiac data of a BSMA patient who was followed up for 10 y. Case report: In a male patient aged 47 y, BSMA was diagnosed at age 37 y upon the typical clinical presentation (postural tremor since age 12 y, dysarthria since age 15 y, muscle cramps since age 29 y, general myalgias since age 32 y, general fasciculations since age 34 y, myoclonic jerks, easy fatigability, dyspnea upon exercise since age 36 y) and a CAG-repeat expansion of 47 ± 1 repeats in the androgen-receptor gene detected at age 37 y...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29158740/xeno-free-strategies-for-safe-human-mesenchymal-stem-stromal-cell-expansion-supplements-and-coatings
#20
REVIEW
M Cimino, R M Gonçalves, C C Barrias, M C L Martins
Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring in vitro expansion. Most of the current protocols for hMSC expansion make use of fetal bovine serum (FBS) as a nutrient-rich supplement. However, regulatory guidelines encourage novel xeno-free alternatives to define safer and standardized protocols for hMSC expansion that preserve their intrinsic therapeutic potential...
2017: Stem Cells International
keyword
keyword
115508
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"