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https://www.readbyqxmd.com/read/29332263/creating-a-primary-care-workforce-strategies-for-leaders-clinicians-and-nurses
#1
Patricia Robinson, Julie Oyemaja, Bridget Beachy, Jeff Goodie, Lisa Sprague, Jennifer Bell, Mike Maples, Christy Ward
Many primary care clinics struggle with rapid implementation and systematic expansion of primary care behavioral health (PCBH) services. Often, an uneven course of program development is due to lack of attention to preparing clinic leadership, addressing operational factors, and training primary care providers (PCPs) and nurses. This article offers competency tools for clinic leaders, PCPs, and nurses to use in assessing their status and setting change targets. These tools were developed by researchers working to disseminate evidence-based interventions in primary care clinics that included fully integrated behavioral health consultants and were then used by early adaptors of the PCBH model...
January 13, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29332164/skewing-of-the-genetic-architecture-at-the-zmym3-human-specific-5-utr-short-tandem-repeat-in-schizophrenia
#2
F Alizadeh, A Bozorgmehr, J Tavakkoly-Bazzaz, M Ohadi
Differential expansion of a number of human short tandem repeats (STRs) at the critical core promoter and 5' untranslated region (UTR) support the hypothesis that at least some of these STRs may provide a selective advantage in human evolution. Following a genome-wide screen of all human protein-coding gene 5' UTRs based on the Ensembl database ( http://www.ensembl.org ), we previously reported that the longest STR in this interval is a (GA)32, which belongs to the X-linked zinc finger MYM-type containing 3 (ZMYM3) gene...
January 13, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29332158/combined-sublethal-irradiation-and-agonist-anti-cd40-enhance-donor-t-cell-accumulation-and-control-of-autochthonous-murine-pancreatic-tumors
#3
Lindsay K Ward-Kavanagh, Kathleen M Kokolus, Timothy K Cooper, Aron E Lukacher, Todd D Schell
Tumor-reactive T lymphocytes can promote the regression of established tumors. However, their efficacy is often limited by immunosuppressive mechanisms that block T cell accumulation or function. ACT provides the opportunity to ameliorate immune suppression prior to transfer of tumor-reactive T cells to improve the therapeutic benefit. We evaluated the combination of lymphodepleting whole body irradiation (WBI) and agonist anti-CD40 (αCD40) antibody on control of established autochthonous murine neuroendocrine pancreatic tumors following the transfer of naïve tumor-specific CD8 T cells...
January 13, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29332130/cerebrospinal-fluid-pressure-revisiting-factors-influencing-optic-nerve-head-biomechanics
#4
Yi Hua, Andrew P Voorhees, Ian A Sigal
Purpose: To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods: We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the optic nerve (CON). A total of 8340 models were studied to predict factor influences on 98 responses in a two-step process: a fractional factorial screening analysis to identify the 16 most influential factors, followed by a response surface methodology to predict factor effects in detail...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29332085/deep-brain-stimulation-of-the-subthalamic-nucleus-and-globus-pallidus-for-parkinson-s-disease
#5
Philip S Lee, Donald J Crammond, R Mark Richardson
The concept of deep brain stimulation (DBS) for Parkinson's disease (PD) was introduced over 20 years ago, but our understanding of the nuances of this procedure continues to improve. The average motor outcomes of internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) DBS appear to be similar, although GPi DBS may allow greater recovery of verbal fluency and may provide greater relief of depression symptoms and improvement in the quality of life, and STN DBS appears more likely to result in decrease in levodopa equivalent doses...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29331835/integrating-priority-areas-and-ecological-corridors-into-national-network-for-conservation-planning-in-china
#6
Jie Liang, Xinyue He, Guangming Zeng, Minzhou Zhong, Xiang Gao, Xin Li, Xiaodong Li, Haipeng Wu, Chunting Feng, Wenle Xing, Yilong Fang, Dan Mo
Considering that urban expansion and increase of human activities represent important threats to biodiversity and ecological processes in short and long term, developing protected area (PA) network with high connectivity is considered as a valuable conservation strategy. However, conservation planning associated with the large-scale network in China involves important information loopholes about the land cover and landscape connectivity. In this paper, we made an integrative analysis for the identification of conservation priority areas and least-cost ecological corridors (ECs) in order to promote a more representative, connected and efficient ecological PA network for this country...
January 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29331648/lung-ultrasound-to-detect-residual-pneumothorax-after-chest-drain-removal-in-lung-resections
#7
Miriam Patella, Andrea Saporito, Carla Puligheddu, Francesco Mongelli, Davide La Regina, Ramon Pini, Rolf Inderbitzi, Stefano Cafarotti
BACKGROUND: Indication for post-drain removal imaging after lung resection is debated. Chest x-ray (CXR) is widely used to confirm lung expansion but not evidence-based. We propose to introduce lung ultrasound (LUS) as alternative to exclude significant pneumothorax (PTx) in this setting. METHODS: Fifty patients undergoing lung resections were enrolled. Inclusion criteria were: complete expansion of the lung at post-operative CXR, pleural effusion <300ml/24h, air leak 10-20ml/min for 6 hours...
January 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29331322/expression-level-of-risk-genes-of-mhc-class-ii-is-a-susceptibility-factor-for-autoimmunity-new-insights
#8
REVIEW
Carmen Gianfran, Laura Pisapia, Stefania Picascia, Maria Strazzullo, Giovanna Del Pozzo
To date, the study of the impact of major hystocompatibility complex on autoimmunity has been prevalently focused on structural diversity of MHC molecules in binding and presentation of (auto)antigens to cognate T cells. Recently, a number of experimental evidences suggested new points of view to investigate the complex relationships between MHC gene expression and the individual predisposition to autoimmune diseases. Irrespective of the nature of the antigen, a threshold of MHC-peptide complexes needs to be reached, as well as a threshold of T cell receptors engaged is required, for the activation and proliferation of autoantigen-reactive T cells...
January 10, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29331266/human-papilloma-virus-specific-t-cells-can-be-generated-from-na%C3%A3-ve-t-cells-for-use-as-an-immunotherapeutic-strategy-for-immunocompromised-patients
#9
Sarah E McCormack, Conrad Russell Y Cruz, Kaylor E Wright, Allison B Powell, Haili Lang, Cornelia Trimble, Michael D Keller, Ephraim Fuchs, Catherine M Bollard
Human papilloma virus (HPV) is a known cause of cervical cancer, squamous cell carcinoma and laryngeal cancer. Although treatments exist for HPV-associated malignancies, patients unresponsive to these therapies have a poor prognosis. Recent findings from vaccine studies suggest that T-cell immunity is essential for disease control. Because Epstein-Barr Virus (EBV)-specific T cells have been highly successful in treating or preventing EBV-associated tumors, we hypothesized that the development of a manufacturing platform for HPV-specific T cells from healthy donors could be used in a third-party setting to treat patients with high-risk/relapsed HPV-associated cancers...
January 10, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29331264/altered-levels-of-the-splicing-factor-muscleblind-modifies-cerebral-cortical-function-in-mouse-models-of-myotonic-dystrophy
#10
Gang Chen, Russell E Carter, John D Cleary, Tammy S Reid, Laura P Ranum, Maurice S Swanson, Timothy J Ebner
Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of alternative splicing factors, including muscleblind (MBNL) proteins. Grey matter loss and white matter changes, including the corpus callosum, likely underlie cognitive and executive function deficits in DM patients. However, little is known how cerebral cortical circuitry changes in DM...
January 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29331246/estimation-of-expected-dengue-seroprevalence-from-passive-epidemiological-surveillance-systems-in-selected-areas-of-argentina-a-proxy-to-evaluate-the-applicability-of-dengue-vaccination
#11
Pablo Orellano, Darío Vezzani, Nancy Quaranta, Julieta Reynoso, Oscar Daniel Salomón
BACKGROUND: Current recommendations about dengue vaccination by the World Health Organization depend on seroprevalence levels and serological status in populations and individuals. However, seroprevalence estimation may be difficult due to a diversity of factors. Thus, estimation through models using data from epidemiological surveillance systems could be an alternative procedure to achieve this goal. OBJECTIVE: To estimate the expected dengue seroprevalence in children of selected areas in Argentina, using a simple model based on data from passive epidemiological surveillance systems...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29331242/species-specific-response-to-sulfide-intrusion-in-native-and-exotic-mediterranean-seagrasses-under-stress
#12
Eugenia T Apostolaki, Marianne Holmer, Veronica Santinelli, Ioannis Karakassis
We explored the sulfur dynamics and the relationships between sediment sulfur and nutrient pools, seagrass structural and physiological variables and sulfide intrusion in native (Posidonia oceanica, Cymodocea nodosa) and exotic (Halophila stipulacea) Mediterranean seagrasses at six sites affected by cumulative anthropogenic pressures to understand the factors controlling sulfide intrusion in seagrass. Sensitive indicators of seagrass stress (leaf TN, δ15N, TS, Fsulfide) were increased at several sites, implying that seagrasses are under pressure...
December 25, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29330927/defined-serum-free-medium-for-bioreactor-culture-of-an-immortalized-human-erythroblast-cell-line
#13
Esmond Lee, Zhong Ri Lim, Hong Yu-Chen, Bin Xia Yang, Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jaichandran Sivalingam, Shaul Reuveny, Yuin-Han Loh, Steve Kah-Weng Oh
Anticipated shortages in donated blood supply have prompted investigation of alternative approaches for in-vitro production of red blood cells (RBCs), such as expansion of conditional immortalization erythroid progenitors. However, there is a bioprocessing challenge wherein factors promoting maximal cell expansion and growth-limiting inhibitory factors are yet to be investigated. We used an erythroblast cell line (ImEry) derived from immortalizing CD71+CD235a+ erythroblast from adult peripheral blood for optimization of expansion culture conditions...
January 13, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29330887/loss-of-vamp5-in-mice-results-in-duplication-of-the-ureter-and-insufficient-expansion-of-the-lung
#14
Maiko Ikezawa, Yuki Tajika, Hitoshi Ueno, Tohru Murakami, Naokazu Inoue, Hiroshi Yorifuji
BACKGROUND: VAMP5 is a member of the SNARE protein family, which regulate the docking and fusion of membrane vesicles within cells. Previously, we reported ubiquitous expression of VAMP5 proteins in various organs except the brain and small intestine. However, the precise roles of VAMP5 in each organ remain unclear. To explore the roles of VAMP5 in vivo, we generated VAMP5 knockout (KO) mice. RESULTS: VAMP5 KO mice showed low birth rate and low body weight. KO embryos grew normally in the uterus, and tended to die around birth...
January 13, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29330730/scaffold-free-tissue-engineering-for-injured-joint-surface-restoration
#15
REVIEW
Kazunori Shimomura, Wataru Ando, Hiromichi Fujie, David A Hart, Hideki Yoshikawa, Norimasa Nakamura
Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in 1994, autologous chondrocyte implantation (ACI) has been introduced into the clinic. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell (MSC)-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330353/afadin-and-rhoa-control-pancreatic-endocrine-mass-via-lumen-morphogenesis
#16
D Berfin Azizoglu, Caitlin Braitsch, Denise K Marciano, Ondine Cleaver
Proper lumen morphogenesis during pancreas development is critical to endocrine and exocrine cell fate. Recent studies showed that a central network of lumens (termed core), but not the surrounding terminal branches (termed periphery), produces most islet endocrine cells. To date, it remains unclear how pancreatic lumens form and remodel and which aspects of lumen morphogenesis influence cell fate. Importantly, models testing the function of the central lumen network as an endocrine niche are lacking. Here, we identify mechanisms underlying lumen formation and remodeling and show that central lumen network morphogenesis impacts pancreatic endocrine mass...
January 12, 2018: Genes & Development
https://www.readbyqxmd.com/read/29330322/cutting-edge-piezo1-mechanosensors-optimize-human-t-cell-activation
#17
Chinky Shiu Chen Liu, Deblina Raychaudhuri, Barnali Paul, Yogaditya Chakrabarty, Amrit Raj Ghosh, Oindrila Rahaman, Arindam Talukdar, Dipyaman Ganguly
TCRs recognize peptides on MHC molecules and induce downstream signaling, leading to activation and clonal expansion. In addition to the strength of the interaction of TCRs with peptides on MHC molecules, mechanical forces contribute to optimal T cell activation, as reflected by the superior efficiency of immobilized TCR-cross-linking Abs compared with soluble Abs in TCR triggering, although a dedicated mechanotransduction module is not identified. We found that the professional mechanosensor protein Piezo1 is critically involved in human T cell activation...
January 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29330268/pelvic-and-buttock-hypoplasia-reconstructed-with-anatomical-breast-implants
#18
Felicity Page, Ayad Harb, Garth Titley
Radiation therapy is used in the management of a number of childhood cancers and can have significant effects on skeletal growth. We present the case of a 35-year-old woman who developed a hypoplastic pelvis and buttocks following radiotherapy for rhabdomyosarcoma of the vagina at the age of 2. At the age of 25, the patient underwent bilateral buttock augmentation with a two-stage reconstruction using tissue expansion followed by definitive augmentation with anatomical breast implant insertion. The patient continues to have a satisfactory outcome 10 years following reconstruction, having undergone a single uplift procedure and exchange of implants through the original incision 9 years postoperatively...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29330102/bisphosphonates-intake-and-its-association-with-changes-of-periarticular-bone-area-and-three-dimensional-shape-data-from-the-osteoarthritis-initiative-oai
#19
Arya Haj-Mirzaian, Ali Guermazi, Frank W Roemer, Mike A Bowes, Philip G Conaghan, Shadpour Demehri
OBJECTIVE: To determine the association between bisphosphonate treatment with the change of periarticular bone area and three-dimensional (3D) shape in participants of the Osteoarthritis Initiative (OAI) study. DESIGN: Using propensity score (PS) matching method in females, 48 bisphosphonate users and 105 non-users, who were matched for OA and osteoporosis related factors were included. Baseline and 24-month MRI-based periarticular bone area and 3D shape measurements were used...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29330048/b-cell-activation-in-the-cecal-patches-during-the-development-of-an-experimental-colitis-model
#20
Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
Although previous studies have suggested that appendix seems to be involved in the colitis, the role of this in the pathogenesis remains unclear. In this study, we assessed the importance of appendiceal lymphoid follicles, specifically the cecal patches (CP) in mice, using an experimental colitis model. Treatment with oxazolone resulted in ulcerations particularly at CP with follicular expansion as well as colitis. The colitis was attenuated by either appendectomy or the absence of mature B cells. We therefore established an intravital imaging system accompanied by the fluorescence resonance energy transfer technology to analyze the dynamic immune response of CP B cells...
January 9, 2018: Biochemical and Biophysical Research Communications
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